n6022 and Pulmonary-Disease--Chronic-Obstructive

n6022 has been researched along with Pulmonary-Disease--Chronic-Obstructive* in 1 studies

Other Studies

1 other study(ies) available for n6022 and Pulmonary-Disease--Chronic-Obstructive

Article	Year
Discovery of 5-(2-chloro-4'-(1H-imidazol-1-yl)-[1,1'-biphenyl]-4-yl)-1H-tetrazole as potent and orally efficacious S-nitrosoglutathione reductase (GSNOR) inhibitors for the potential treatment of COPD. Bioorganic & medicinal chemistry letters, 2018, 12-15, Volume: 28, Issue:23-24 Endogenous nitrosothiols (SNOs) including S-nitrosoglutathione (GSNO) serve as reservoir for bioavailable nitric oxide (NO) and mediate NO-based signaling, inflammatory status and smooth muscle function in the lung. GSNOR inhibition increases pulmonary GSNO and induces bronchodilation while reducing inflammation in lung diseases. In this letter, design, synthesis and structure-activity relationships (SAR) of novel imidazole-biaryl-tetrazole based GSNOR inhibitors are described. Many potent inhibitors (30, 39, 41, 42, 44, 45 and 58) were identified with low nanomolar activity (IC Topics: Administration, Oral; Aldehyde Oxidoreductases; Animals; Cigarette Smoking; Enzyme Inhibitors; Halogenation; Humans; Imidazoles; Male; Mice; Mice, Inbred C57BL; Pulmonary Disease, Chronic Obstructive; Structure-Activity Relationship; Tetrazoles	2018

Article

Year

Discovery of 5-(2-chloro-4'-(1H-imidazol-1-yl)-[1,1'-biphenyl]-4-yl)-1H-tetrazole as potent and orally efficacious S-nitrosoglutathione reductase (GSNOR) inhibitors for the potential treatment of COPD.

Bioorganic & medicinal chemistry letters, 2018, 12-15, Volume: 28, Issue:23-24

Endogenous nitrosothiols (SNOs) including S-nitrosoglutathione (GSNO) serve as reservoir for bioavailable nitric oxide (NO) and mediate NO-based signaling, inflammatory status and smooth muscle function in the lung. GSNOR inhibition increases pulmonary GSNO and induces bronchodilation while reducing inflammation in lung diseases. In this letter, design, synthesis and structure-activity relationships (SAR) of novel imidazole-biaryl-tetrazole based GSNOR inhibitors are described. Many potent inhibitors (30, 39, 41, 42, 44, 45 and 58) were identified with low nanomolar activity (IC

Topics: Administration, Oral; Aldehyde Oxidoreductases; Animals; Cigarette Smoking; Enzyme Inhibitors; Halogenation; Humans; Imidazoles; Male; Mice; Mice, Inbred C57BL; Pulmonary Disease, Chronic Obstructive; Structure-Activity Relationship; Tetrazoles

2018