Compounds > n-succinimidyl-4-fluorobenzoate

n-succinimidyl-4-fluorobenzoate and Breast-Neoplasms

n-succinimidyl-4-fluorobenzoate has been researched along with Breast-Neoplasms* in 2 studies

Other Studies

2 other study(ies) available for n-succinimidyl-4-fluorobenzoate and Breast-Neoplasms

Article	Year
Labeling Single Domain Antibody Fragments with Fluorine-18 Using 2,3,5,6-Tetrafluorophenyl 6-[ Molecular pharmaceutics, 2019, 01-07, Volume: 16, Issue:1 ImmunoPET agents are being investigated to assess the status of epidermal growth factor receptor 2 (HER2) in breast cancer patients with the goal of selecting those likely to benefit from HER2-targeted therapies and monitoring their progress after these treatments. We have been exploring the use of single domain antibody fragments (sdAbs) labeled with Topics: Animals; Apoptosis; Benzoates; Blotting, Western; Breast Neoplasms; Cell Cycle Checkpoints; Cell Line, Tumor; Cytochromes c; DNA Fragmentation; Female; Flow Cytometry; Fluorine Radioisotopes; Humans; Iodine Radioisotopes; Kidney; Mice; Radiopharmaceuticals; Receptor, ErbB-2; Single-Domain Antibodies; Succinimides; Xenograft Model Antitumor Assays	2019
Rapid and one-step radiofluorination of bioactive peptides: potential PET radiopharmaceuticals. Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 2014, Volume: 91 In an attempt to develop a new and rapid method for labeling peptides with (18)F, we have synthesized MUC1-[(18)F]SFB and BBN-[(18)F]SFB peptide conjugates using a convenient and one-step simple reactions. Radiochemical yields for MUC1-[(18)F]SFB and BBN-[(18)F]SFB peptide conjugates were greater than 70% in less than 30 min synthesis time, thus amenable for automation for the radiofluorination of peptides. in vitro tests on T47D breast cancer cells showed that the significant amounts of the radioconjugates were associated with cell fractions and held sufficient affinities and specificities toward T47D cell line. These radioconjugates may be useful as molecular probes for detecting and staging of breast cancer and monitoring tumor response to treatment. Topics: Benzoates; Bombesin; Breast Neoplasms; Cell Line, Tumor; Female; Fluorine Radioisotopes; Humans; Isotope Labeling; Mucin-1; Positron-Emission Tomography; Radiopharmaceuticals; Succinimides	2014

Article

Year

Labeling Single Domain Antibody Fragments with Fluorine-18 Using 2,3,5,6-Tetrafluorophenyl 6-[

Molecular pharmaceutics, 2019, 01-07, Volume: 16, Issue:1

ImmunoPET agents are being investigated to assess the status of epidermal growth factor receptor 2 (HER2) in breast cancer patients with the goal of selecting those likely to benefit from HER2-targeted therapies and monitoring their progress after these treatments. We have been exploring the use of single domain antibody fragments (sdAbs) labeled with

Topics: Animals; Apoptosis; Benzoates; Blotting, Western; Breast Neoplasms; Cell Cycle Checkpoints; Cell Line, Tumor; Cytochromes c; DNA Fragmentation; Female; Flow Cytometry; Fluorine Radioisotopes; Humans; Iodine Radioisotopes; Kidney; Mice; Radiopharmaceuticals; Receptor, ErbB-2; Single-Domain Antibodies; Succinimides; Xenograft Model Antitumor Assays

2019

Rapid and one-step radiofluorination of bioactive peptides: potential PET radiopharmaceuticals.

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 2014, Volume: 91

In an attempt to develop a new and rapid method for labeling peptides with (18)F, we have synthesized MUC1-[(18)F]SFB and BBN-[(18)F]SFB peptide conjugates using a convenient and one-step simple reactions. Radiochemical yields for MUC1-[(18)F]SFB and BBN-[(18)F]SFB peptide conjugates were greater than 70% in less than 30 min synthesis time, thus amenable for automation for the radiofluorination of peptides. in vitro tests on T47D breast cancer cells showed that the significant amounts of the radioconjugates were associated with cell fractions and held sufficient affinities and specificities toward T47D cell line. These radioconjugates may be useful as molecular probes for detecting and staging of breast cancer and monitoring tumor response to treatment.

Topics: Benzoates; Bombesin; Breast Neoplasms; Cell Line, Tumor; Female; Fluorine Radioisotopes; Humans; Isotope Labeling; Mucin-1; Positron-Emission Tomography; Radiopharmaceuticals; Succinimides

2014