n-stearoyl-dopamine and Anthrax

n-stearoyl-dopamine has been researched along with Anthrax* in 1 studies

Other Studies

1 other study(ies) available for n-stearoyl-dopamine and Anthrax

Article	Year
Inhibitors of anthrax lethal factor based upon N-oleoyldopamine. Bioorganic & medicinal chemistry letters, 2008, Apr-01, Volume: 18, Issue:7 The structural features of an anthrax lethal factor inhibitor, N-oleoyldopamine (OLDA, 1) have been probed. The oleic acid moiety is critical, but, more interestingly, the presence of the double bond and its geometry were found to play an essential role. One compound, 5, was found to be an uncompetitive inhibitor of lethal factor (LF) with a K(i) value of 2.2microM and a cell-based IC(50) value of 4.3microM. Topics: Anthrax; Antigens, Bacterial; Antitoxins; Bacterial Toxins; Dopamine; Inhibitory Concentration 50; Oleic Acid; Structure-Activity Relationship	2008

Article

Year

Inhibitors of anthrax lethal factor based upon N-oleoyldopamine.

Bioorganic & medicinal chemistry letters, 2008, Apr-01, Volume: 18, Issue:7

The structural features of an anthrax lethal factor inhibitor, N-oleoyldopamine (OLDA, 1) have been probed. The oleic acid moiety is critical, but, more interestingly, the presence of the double bond and its geometry were found to play an essential role. One compound, 5, was found to be an uncompetitive inhibitor of lethal factor (LF) with a K(i) value of 2.2microM and a cell-based IC(50) value of 4.3microM.

Topics: Anthrax; Antigens, Bacterial; Antitoxins; Bacterial Toxins; Dopamine; Inhibitory Concentration 50; Oleic Acid; Structure-Activity Relationship

2008