n-oleoylethanolamine and Ischemic-Attack--Transient

n-oleoylethanolamine has been researched along with Ischemic-Attack--Transient* in 1 studies

Other Studies

1 other study(ies) available for n-oleoylethanolamine and Ischemic-Attack--Transient

Article	Year
Chronic oleoylethanolamide treatment improves spatial cognitive deficits through enhancing hippocampal neurogenesis after transient focal cerebral ischemia. Biochemical pharmacology, 2015, Apr-15, Volume: 94, Issue:4 Oleoylethanolamide (OEA) has been shown to have neuroprotective effects after acute cerebral ischemic injury. The aim of this study was to investigate the effects of chronic OEA treatment on ischemia-induced spatial cognitive impairments, electrophysiology behavior and hippocampal neurogenesis. Daily treatments of 30 mg/kg OEA significantly ameliorated spatial cognitive deficits and attenuated the inhibition of long-term potentiation (LTP) in the middle cerebral artery occlusion (MCAO) rat model. Moreover, OEA administration improved cognitive function in a manner associated with enhanced neurogenesis in the hippocampus. Further study demonstrated that treatment with OEA markedly increased the expressions of brain-derived neurotrophic factor (BDNF) and peroxisome proliferator-activated receptors α (PPARα). Our data suggest that chronic OEA treatment can exert functional recovery of cognitive impairments and neuroprotective effects against cerebral ischemic insult in rats via triggering of neurogenesis in the hippocampus, which supports the therapeutic use of OEA for cerebral ischemia. Topics: Animals; Brain-Derived Neurotrophic Factor; Cognition Disorders; Dentate Gyrus; Endocannabinoids; Hippocampus; Ischemic Attack, Transient; Long-Term Potentiation; Male; Maze Learning; Neurogenesis; Neuroglia; Neurons; Oleic Acids; PPAR alpha; Rats, Sprague-Dawley; Spatial Learning	2015

Article

Year

Chronic oleoylethanolamide treatment improves spatial cognitive deficits through enhancing hippocampal neurogenesis after transient focal cerebral ischemia.

Biochemical pharmacology, 2015, Apr-15, Volume: 94, Issue:4

Oleoylethanolamide (OEA) has been shown to have neuroprotective effects after acute cerebral ischemic injury. The aim of this study was to investigate the effects of chronic OEA treatment on ischemia-induced spatial cognitive impairments, electrophysiology behavior and hippocampal neurogenesis. Daily treatments of 30 mg/kg OEA significantly ameliorated spatial cognitive deficits and attenuated the inhibition of long-term potentiation (LTP) in the middle cerebral artery occlusion (MCAO) rat model. Moreover, OEA administration improved cognitive function in a manner associated with enhanced neurogenesis in the hippocampus. Further study demonstrated that treatment with OEA markedly increased the expressions of brain-derived neurotrophic factor (BDNF) and peroxisome proliferator-activated receptors α (PPARα). Our data suggest that chronic OEA treatment can exert functional recovery of cognitive impairments and neuroprotective effects against cerebral ischemic insult in rats via triggering of neurogenesis in the hippocampus, which supports the therapeutic use of OEA for cerebral ischemia.

Topics: Animals; Brain-Derived Neurotrophic Factor; Cognition Disorders; Dentate Gyrus; Endocannabinoids; Hippocampus; Ischemic Attack, Transient; Long-Term Potentiation; Male; Maze Learning; Neurogenesis; Neuroglia; Neurons; Oleic Acids; PPAR alpha; Rats, Sprague-Dawley; Spatial Learning

2015