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n,n,n',n'-tetrakis(2-pyridylmethyl)ethylenediamine and Precursor Cell Lymphoblastic Leukemia-Lymphoma

n,n,n',n'-tetrakis(2-pyridylmethyl)ethylenediamine has been researched along with Precursor Cell Lymphoblastic Leukemia-Lymphoma in 3 studies

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine: a zinc ion chelating agent; structure given in first source
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine : An N-substituted diamine that is ethylenediamine in which the four amino hydrogens are replaced by 2-pyridylmethyl groups.

Precursor Cell Lymphoblastic Leukemia-Lymphoma: A neoplasm characterized by abnormalities of the lymphoid cell precursors leading to excessive lymphoblasts in the marrow and other organs. It is the most common cancer in children and accounts for the vast majority of all childhood leukemias.

Research Excerpts

ExcerptRelevanceReference
"Acute lymphoblastic leukemia (ALL) is hematological neoplasia that affects human beings from early life to adulthood."1.72TPEN/TPGS (T2) combo dramatically reduces Philadelphia chromosome-positive pro-lymphoblastic B leukemia in BALB/c mice. ( Jimenez-Del-Rio, M; Mendivil-Perez, M; Velez-Pardo, C, 2022)
"Acute lymphoblastic leukemia is still an incurable disease with resistance to therapy developing in the majority of patients."1.38TPEN induces apoptosis independently of zinc chelator activity in a model of acute lymphoblastic leukemia and ex vivo acute leukemia cells through oxidative stress and mitochondria caspase-3- and AIF-dependent pathways. ( Jimenez-Del-Rio, M; Mendivil-Perez, M; Velez-Pardo, C, 2012)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's1 (33.33)24.3611
2020's2 (66.67)2.80

Authors

AuthorsStudies
Mendivil-Perez, M3
Velez-Pardo, C3
Quiroz-Duque, LM1
Restrepo-Rincon, A1
Valencia-Zuluaga, NA1
Jimenez-Del-Rio, M3

Other Studies

3 other studies available for n,n,n',n'-tetrakis(2-pyridylmethyl)ethylenediamine and Precursor Cell Lymphoblastic Leukemia-Lymphoma

ArticleYear
TPEN selectively eliminates lymphoblastic B cells from bone marrow pediatric acute lymphoblastic leukemia patients.
    Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 2022, Volume: 35, Issue:4

    Topics: Antigens, CD19; Bone Marrow; Child; Ethylenediamines; Humans; Hydrogen Peroxide; Immunophenotyping;

2022
TPEN/TPGS (T2) combo dramatically reduces Philadelphia chromosome-positive pro-lymphoblastic B leukemia in BALB/c mice.
    Medical oncology (Northwood, London, England), 2022, Nov-09, Volume: 40, Issue:1

    Topics: Adult; Animals; Fusion Proteins, bcr-abl; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive;

2022
TPEN induces apoptosis independently of zinc chelator activity in a model of acute lymphoblastic leukemia and ex vivo acute leukemia cells through oxidative stress and mitochondria caspase-3- and AIF-dependent pathways.
    Oxidative medicine and cellular longevity, 2012, Volume: 2012

    Topics: Acetylcysteine; Apoptosis; Apoptosis Inducing Factor; Caspase 3; Cell Nucleus; Chelating Agents; Chr

2012