n,n,n',n'-tetrakis(2-pyridylmethyl)ethylenediamine has been researched along with Precursor Cell Lymphoblastic Leukemia-Lymphoma in 3 studies
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine: a zinc ion chelating agent; structure given in first source
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine : An N-substituted diamine that is ethylenediamine in which the four amino hydrogens are replaced by 2-pyridylmethyl groups.
Precursor Cell Lymphoblastic Leukemia-Lymphoma: A neoplasm characterized by abnormalities of the lymphoid cell precursors leading to excessive lymphoblasts in the marrow and other organs. It is the most common cancer in children and accounts for the vast majority of all childhood leukemias.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Acute lymphoblastic leukemia (ALL) is hematological neoplasia that affects human beings from early life to adulthood." | 1.72 | TPEN/TPGS (T2) combo dramatically reduces Philadelphia chromosome-positive pro-lymphoblastic B leukemia in BALB/c mice. ( Jimenez-Del-Rio, M; Mendivil-Perez, M; Velez-Pardo, C, 2022) |
| "Acute lymphoblastic leukemia is still an incurable disease with resistance to therapy developing in the majority of patients." | 1.38 | TPEN induces apoptosis independently of zinc chelator activity in a model of acute lymphoblastic leukemia and ex vivo acute leukemia cells through oxidative stress and mitochondria caspase-3- and AIF-dependent pathways. ( Jimenez-Del-Rio, M; Mendivil-Perez, M; Velez-Pardo, C, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 2 (66.67) | 2.80 |
| Authors | Studies |
|---|---|
| Mendivil-Perez, M | 3 |
| Velez-Pardo, C | 3 |
| Quiroz-Duque, LM | 1 |
| Restrepo-Rincon, A | 1 |
| Valencia-Zuluaga, NA | 1 |
| Jimenez-Del-Rio, M | 3 |
3 other studies available for n,n,n',n'-tetrakis(2-pyridylmethyl)ethylenediamine and Precursor Cell Lymphoblastic Leukemia-Lymphoma
| Article | Year |
|---|---|
TPEN selectively eliminates lymphoblastic B cells from bone marrow pediatric acute lymphoblastic leukemia patients.
Topics: Antigens, CD19; Bone Marrow; Child; Ethylenediamines; Humans; Hydrogen Peroxide; Immunophenotyping; | 2022 |
TPEN/TPGS (T2) combo dramatically reduces Philadelphia chromosome-positive pro-lymphoblastic B leukemia in BALB/c mice.
Topics: Adult; Animals; Fusion Proteins, bcr-abl; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; | 2022 |
TPEN induces apoptosis independently of zinc chelator activity in a model of acute lymphoblastic leukemia and ex vivo acute leukemia cells through oxidative stress and mitochondria caspase-3- and AIF-dependent pathways.
Topics: Acetylcysteine; Apoptosis; Apoptosis Inducing Factor; Caspase 3; Cell Nucleus; Chelating Agents; Chr | 2012 |