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n,n,n',n'-tetrakis(2-pyridylmethyl)ethylenediamine and Neuroblastoma

n,n,n',n'-tetrakis(2-pyridylmethyl)ethylenediamine has been researched along with Neuroblastoma in 6 studies

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine: a zinc ion chelating agent; structure given in first source
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine : An N-substituted diamine that is ethylenediamine in which the four amino hydrogens are replaced by 2-pyridylmethyl groups.

Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (33.33)18.2507
2000's2 (33.33)29.6817
2010's2 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ohkubo, M1
Miyamoto, A1
Shiraishi, M1
Matias, AC1
Manieri, TM1
Cerchiaro, G1
Sakabe, I1
Paul, S1
Dansithong, W1
Shinozawa, T1
Adler, M1
Shafer, H1
Hamilton, T1
Petrali, JP1
Ho, LH1
Ratnaike, RN1
Zalewski, PD1
Ahn, YH1
Koh, JY1
Hong, SH1

Other Studies

6 other studies available for n,n,n',n'-tetrakis(2-pyridylmethyl)ethylenediamine and Neuroblastoma

ArticleYear
Heavy metal chelator TPEN attenuates fura-2 fluorescence changes induced by cadmium, mercury and methylmercury.
    The Journal of veterinary medical science, 2016, Jun-01, Volume: 78, Issue:5

    Topics: Boron Compounds; Cadmium Poisoning; Calcium; Calcium Channel Blockers; Cell Line, Tumor; Chelating A

2016
Zinc Chelation Mediates the Lysosomal Disruption without Intracellular ROS Generation.
    Oxidative medicine and cellular longevity, 2016, Volume: 2016

    Topics: Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Caspase 3; Cell Line, Tumor; Cell Survival

2016
Induction of apoptosis in Neuro-2A cells by Zn2+ chelating.
    Cell structure and function, 1998, Volume: 23, Issue:2

    Topics: Animals; Apoptosis; Cell Division; Cell Nucleus; Chelating Agents; Copper; DNA Fragmentation; Dose-R

1998
Cytotoxic actions of the heavy metal chelator TPEN on NG108-15 neuroblastoma-glioma cells.
    Neurotoxicology, 1999, Volume: 20, Issue:4

    Topics: Animals; Apoptosis; Biomarkers; Cell Aggregation; Cell Nucleus; Cell Survival; Chelating Agents; Chr

1999
Involvement of intracellular labile zinc in suppression of DEVD-caspase activity in human neuroblastoma cells.
    Biochemical and biophysical research communications, 2000, Feb-05, Volume: 268, Issue:1

    Topics: Alzheimer Disease; Apoptosis; Caspase 3; Caspase Inhibitors; Caspases; Chelating Agents; Coumarins;

2000
Protein synthesis-dependent but Bcl-2-independent cytochrome C release in zinc depletion-induced neuronal apoptosis.
    Journal of neuroscience research, 2000, Sep-01, Volume: 61, Issue:5

    Topics: Animals; Apoptosis; Cells, Cultured; Cerebral Cortex; Cholinesterase Inhibitors; Cytochrome c Group;

2000