n,n,n',n'-tetrakis(2-pyridylmethyl)ethylenediamine has been researched along with Infarction, Middle Cerebral Artery in 8 studies
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine: a zinc ion chelating agent; structure given in first source
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine : An N-substituted diamine that is ethylenediamine in which the four amino hydrogens are replaced by 2-pyridylmethyl groups.
Infarction, Middle Cerebral Artery: NECROSIS occurring in the MIDDLE CEREBRAL ARTERY distribution system which brings blood to the entire lateral aspects of each CEREBRAL HEMISPHERE. Clinical signs include impaired cognition; APHASIA; AGRAPHIA; weak and numbness in the face and arms, contralaterally or bilaterally depending on the infarction.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Our findings reveal a novel mechanism of cerebral ischemia-induced BBB damage, and implicate zinc as an effective and viable new target for reducing acute BBB damage following ischemic stroke." | 1.43 | Zinc contributes to acute cerebral ischemia-induced blood-brain barrier disruption. ( Dong, W; Ji, X; Liang, J; Liu, KJ; Luo, Y; Pan, R; Qi, Z; Shen, J; Shi, W; Yang, Y; Zhao, Y, 2016) |
| "In a rat transient middle cerebral artery occlusion (MCAO) model, the infarction volume, which is related to the neurotoxicity of glutamate, increased rapidly on the intracerebral ventricular injection of CaEDTA 30 min prior to occlusion." | 1.33 | Protective effect of zinc against ischemic neuronal injury in a middle cerebral artery occlusion model. ( Abe, J; Igarashi, K; Iida, Y; Kasuya, F; Kitamura, Y; Mifune, M; Ohta, M; Saito, Y; Saji, H; Ueda, M, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 7 (87.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhong, YH | 1 |
| Dhawan, J | 1 |
| Kovoor, JA | 1 |
| Sullivan, J | 1 |
| Zhang, WX | 1 |
| Choi, D | 1 |
| Biegon, A | 1 |
| Zhao, Y | 4 |
| Yan, F | 2 |
| Yin, J | 2 |
| Pan, R | 3 |
| Shi, W | 3 |
| Qi, Z | 4 |
| Fang, Y | 1 |
| Huang, Y | 1 |
| Li, S | 2 |
| Luo, Y | 4 |
| Ji, X | 4 |
| Liu, KJ | 4 |
| Yan, Y | 1 |
| Lee, JY | 1 |
| Oh, SB | 1 |
| Hwang, JJ | 1 |
| Suh, N | 1 |
| Jo, DG | 1 |
| Kim, JS | 1 |
| Koh, JY | 1 |
| Dong, W | 2 |
| Liang, J | 2 |
| Wang, WM | 1 |
| Liu, Z | 1 |
| Liu, AJ | 1 |
| Wang, YX | 1 |
| Wang, HG | 1 |
| An, D | 1 |
| Heng, B | 1 |
| Xie, LH | 1 |
| Duan, JL | 1 |
| Liu, YQ | 1 |
| Shen, J | 1 |
| Yang, Y | 1 |
| Kitamura, Y | 1 |
| Iida, Y | 1 |
| Abe, J | 1 |
| Ueda, M | 1 |
| Mifune, M | 1 |
| Kasuya, F | 1 |
| Ohta, M | 1 |
| Igarashi, K | 1 |
| Saito, Y | 1 |
| Saji, H | 1 |
8 other studies available for n,n,n',n'-tetrakis(2-pyridylmethyl)ethylenediamine and Infarction, Middle Cerebral Artery
| Article | Year |
|---|---|
Aromatase and neuroinflammation in rat focal brain ischemia.
Topics: Animals; Aromatase; Brain; Chelating Agents; Ethylenediamines; Excitatory Amino Acid Antagonists; Hu | 2017 |
Synergistic Interaction Between Zinc and Reactive Oxygen Species Amplifies Ischemic Brain Injury in Rats.
Topics: Animals; Antioxidants; Apoptosis; Biphenyl Compounds; Brain; Brain Ischemia; Chelating Agents; Ethyl | 2018 |
Chelating intracellularly accumulated zinc decreased ischemic brain injury through reducing neuronal apoptotic death.
Topics: Animals; Apoptosis; Brain Ischemia; Chelating Agents; Cytosol; Ethylenediamines; Infarction, Middle | 2014 |
Indomethacin preconditioning induces ischemic tolerance by modifying zinc availability in the brain.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain; Carrier Proteins; Cell Death; Chelating Age | 2015 |
Reduction of zinc accumulation in mitochondria contributes to decreased cerebral ischemic injury by normobaric hyperoxia treatment in an experimental stroke model.
Topics: Analysis of Variance; Animals; Brain; Cholinesterase Inhibitors; Cytochromes c; Disease Models, Anim | 2015 |
The Zinc Ion Chelating Agent TPEN Attenuates Neuronal Death/apoptosis Caused by Hypoxia/ischemia Via Mediating the Pathophysiological Cascade Including Excitotoxicity, Oxidative Stress, and Inflammation.
Topics: Animals; Apoptosis; Brain; Brain Ischemia; Cell Hypoxia; Chelating Agents; Disease Models, Animal; E | 2015 |
Zinc contributes to acute cerebral ischemia-induced blood-brain barrier disruption.
Topics: Animals; Blood-Brain Barrier; Brain Ischemia; Ethylenediamines; Infarction, Middle Cerebral Artery; | 2016 |
Protective effect of zinc against ischemic neuronal injury in a middle cerebral artery occlusion model.
Topics: Animals; Calcium; Calcium Radioisotopes; Cell Culture Techniques; Cell Survival; Cells, Cultured; Ch | 2006 |