n,n,n',n'-tetrakis(2-pyridylmethyl)ethylenediamine has been researched along with Disease Models, Animal in 16 studies
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine: a zinc ion chelating agent; structure given in first source
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine : An N-substituted diamine that is ethylenediamine in which the four amino hydrogens are replaced by 2-pyridylmethyl groups.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Here, we investigate the effects of a zinc chelator, N,N,N',N'-tetrakis (2-pyridyl-methyl) ethylenediamine (TPEN), on asthmatic responses in mouse models of ovalbumin (OVA)-induced airway hyperresponsiveness and allergic airway inflammation." | 3.77 | A zinc chelator TPEN attenuates airway hyperresponsiveness and airway inflammation in mice in vivo. ( Asai, Y; Fukuyama, S; Inoue, H; Matsumoto, K; Matsumoto, T; Matsunaga, Y; Moriwaki, A; Nakanishi, Y; Nakano, T; Noda, N; Zhanghui, W, 2011) |
| "Fibrosarcoma is a skin tumor that is frequently observed in humans, dogs, and cats." | 1.51 | Loss of the dermis zinc transporter ZIP13 promotes the mildness of fibrosarcoma by inhibiting autophagy. ( Baek, JM; Bin, BH; Brito, S; Chae, S; Choi, MA; Heo, H; In, KR; Jang, D; Jo, H; Kang, MA; Kim, DO; Kim, JR; Kim, ST; Lee, JS; Lee, MG; Park, H, 2019) |
| "Development of behavioral Racine seizure stages was recorded by a blinded investigator." | 1.35 | Hippocampal zinc infusion delays the development of afterdischarges and seizures in a kindling model of epilepsy. ( Elsas, SM; Gregory, WL; Hazany, S; Mody, I, 2009) |
| "In the cultures exposed to pure anoxia, a significant increase of p53 and BAX immunoreactivity, associated with the decreased level of BCL-2 and BCL-X immunopositive cells was observed, related to the activation of apoptotic process." | 1.33 | Expression of apoptosis-related proteins in model of anoxia in vitro. ( Matyja, E; Nagańska, E, 2005) |
| "In a rat transient middle cerebral artery occlusion (MCAO) model, the infarction volume, which is related to the neurotoxicity of glutamate, increased rapidly on the intracerebral ventricular injection of CaEDTA 30 min prior to occlusion." | 1.33 | Protective effect of zinc against ischemic neuronal injury in a middle cerebral artery occlusion model. ( Abe, J; Igarashi, K; Iida, Y; Kasuya, F; Kitamura, Y; Mifune, M; Ohta, M; Saito, Y; Saji, H; Ueda, M, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (25.00) | 29.6817 |
| 2010's | 8 (50.00) | 24.3611 |
| 2020's | 4 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Yang, H | 1 |
| Kundra, S | 1 |
| Chojnacki, M | 1 |
| Liu, K | 1 |
| Fuse, MA | 1 |
| Abouelhassan, Y | 1 |
| Kallifidas, D | 1 |
| Zhang, P | 1 |
| Huang, G | 1 |
| Jin, S | 1 |
| Ding, Y | 1 |
| Luesch, H | 1 |
| Rohde, KH | 1 |
| Dunman, PM | 1 |
| Lemos, JA | 1 |
| Huigens, RW | 1 |
| Lee, MG | 1 |
| Choi, MA | 1 |
| Chae, S | 1 |
| Kang, MA | 1 |
| Jo, H | 1 |
| Baek, JM | 1 |
| In, KR | 1 |
| Park, H | 1 |
| Heo, H | 1 |
| Jang, D | 1 |
| Brito, S | 1 |
| Kim, ST | 1 |
| Kim, DO | 1 |
| Lee, JS | 1 |
| Kim, JR | 1 |
| Bin, BH | 1 |
| Higashimura, Y | 1 |
| Takagi, T | 1 |
| Naito, Y | 1 |
| Uchiyama, K | 1 |
| Mizushima, K | 1 |
| Tanaka, M | 1 |
| Hamaguchi, M | 1 |
| Itoh, Y | 1 |
| Kimura, H | 1 |
| Yoneya, Y | 1 |
| Mikawa, S | 1 |
| Kaji, N | 1 |
| Ito, H | 1 |
| Tsuchida, Y | 1 |
| Komatsu, H | 1 |
| Murata, T | 1 |
| Ozaki, H | 1 |
| Uchida, R | 1 |
| Nishida, K | 1 |
| Hori, M | 1 |
| Tamano, H | 1 |
| Nishio, R | 1 |
| Morioka, H | 1 |
| Takeda, A | 1 |
| Hamon, R | 1 |
| Homan, CC | 1 |
| Tran, HB | 1 |
| Mukaro, VR | 1 |
| Lester, SE | 1 |
| Roscioli, E | 1 |
| Bosco, MD | 1 |
| Murgia, CM | 1 |
| Ackland, ML | 1 |
| Jersmann, HP | 1 |
| Lang, C | 1 |
| Zalewski, PD | 1 |
| Hodge, SJ | 1 |
| Lee, JY | 1 |
| Oh, SB | 1 |
| Hwang, JJ | 1 |
| Suh, N | 1 |
| Jo, DG | 1 |
| Kim, JS | 1 |
| Koh, JY | 1 |
| Dong, W | 1 |
| Qi, Z | 1 |
| Liang, J | 1 |
| Shi, W | 1 |
| Zhao, Y | 1 |
| Luo, Y | 1 |
| Ji, X | 1 |
| Liu, KJ | 1 |
| Chi, T | 1 |
| Kim, MS | 1 |
| Lang, S | 1 |
| Bose, N | 1 |
| Kahn, A | 1 |
| Flechner, L | 1 |
| Blaschko, SD | 1 |
| Zee, T | 1 |
| Muteliefu, G | 1 |
| Bond, N | 1 |
| Kolipinski, M | 1 |
| Fakra, SC | 1 |
| Mandel, N | 1 |
| Miller, J | 1 |
| Ramanathan, A | 1 |
| Killilea, DW | 1 |
| Brückner, K | 1 |
| Kapahi, P | 1 |
| Stoller, ML | 1 |
| Wang, WM | 1 |
| Liu, Z | 1 |
| Liu, AJ | 1 |
| Wang, YX | 1 |
| Wang, HG | 1 |
| An, D | 1 |
| Heng, B | 1 |
| Xie, LH | 1 |
| Duan, JL | 1 |
| Liu, YQ | 1 |
| Elsas, SM | 1 |
| Hazany, S | 1 |
| Gregory, WL | 1 |
| Mody, I | 1 |
| Medvedeva, YV | 1 |
| Lin, B | 1 |
| Shuttleworth, CW | 1 |
| Weiss, JH | 1 |
| Fukuyama, S | 1 |
| Matsunaga, Y | 1 |
| Zhanghui, W | 1 |
| Noda, N | 1 |
| Asai, Y | 1 |
| Moriwaki, A | 1 |
| Matsumoto, T | 1 |
| Nakano, T | 1 |
| Matsumoto, K | 1 |
| Nakanishi, Y | 1 |
| Inoue, H | 1 |
| Nagańska, E | 1 |
| Matyja, E | 1 |
| Kitamura, Y | 1 |
| Iida, Y | 1 |
| Abe, J | 1 |
| Ueda, M | 1 |
| Mifune, M | 1 |
| Kasuya, F | 1 |
| Ohta, M | 1 |
| Igarashi, K | 1 |
| Saito, Y | 1 |
| Saji, H | 1 |
16 other studies available for n,n,n',n'-tetrakis(2-pyridylmethyl)ethylenediamine and Disease Models, Animal
| Article | Year |
|---|---|
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
A Modular Synthetic Route Involving
Topics: Aniline Compounds; Animals; Anti-Bacterial Agents; Biofilms; Cell Line; Cell Survival; Disease Model | 2021 |
Loss of the dermis zinc transporter ZIP13 promotes the mildness of fibrosarcoma by inhibiting autophagy.
Topics: Animals; Autophagy; Azacitidine; Cation Transport Proteins; Cell Death; Cell Line; Dermis; Disease M | 2019 |
Zinc Deficiency Activates the IL-23/Th17 Axis to Aggravate Experimental Colitis in Mice.
Topics: Animals; Carrier Proteins; Chelating Agents; Deficiency Diseases; Disease Models, Animal; Disease Pr | 2020 |
A new zinc chelator, IPZ-010 ameliorates postoperative ileus.
Topics: Adenosine Triphosphate; Animals; Anti-Inflammatory Agents; Antigens, CD; Antigens, Differentiation, | 2020 |
Extracellular Zn
Topics: Animals; Calcium; Chelating Agents; Disease Models, Animal; Dopaminergic Neurons; Ethylenediamines; | 2019 |
Zinc and zinc transporters in macrophages and their roles in efferocytosis in COPD.
Topics: Animals; Bronchoalveolar Lavage Fluid; Carrier Proteins; Cation Transport Proteins; Cell Line; Cytos | 2014 |
Indomethacin preconditioning induces ischemic tolerance by modifying zinc availability in the brain.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain; Carrier Proteins; Cell Death; Chelating Age | 2015 |
Reduction of zinc accumulation in mitochondria contributes to decreased cerebral ischemic injury by normobaric hyperoxia treatment in an experimental stroke model.
Topics: Analysis of Variance; Animals; Brain; Cholinesterase Inhibitors; Cytochromes c; Disease Models, Anim | 2015 |
A Drosophila model identifies a critical role for zinc in mineralization for kidney stone disease.
Topics: Allopurinol; Animals; Cation Transport Proteins; Chelating Agents; Dietary Proteins; Disease Models, | 2015 |
The Zinc Ion Chelating Agent TPEN Attenuates Neuronal Death/apoptosis Caused by Hypoxia/ischemia Via Mediating the Pathophysiological Cascade Including Excitotoxicity, Oxidative Stress, and Inflammation.
Topics: Animals; Apoptosis; Brain; Brain Ischemia; Cell Hypoxia; Chelating Agents; Disease Models, Animal; E | 2015 |
Hippocampal zinc infusion delays the development of afterdischarges and seizures in a kindling model of epilepsy.
Topics: Analysis of Variance; Animals; Chelating Agents; Chlorides; Disease Models, Animal; Drug Delivery Sy | 2009 |
Intracellular Zn2+ accumulation contributes to synaptic failure, mitochondrial depolarization, and cell death in an acute slice oxygen-glucose deprivation model of ischemia.
Topics: Animals; Calcium; Cell Death; Chelating Agents; Disease Models, Animal; Ethylenediamines; Excitatory | 2009 |
A zinc chelator TPEN attenuates airway hyperresponsiveness and airway inflammation in mice in vivo.
Topics: Allergens; Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Chelating Agent | 2011 |
Expression of apoptosis-related proteins in model of anoxia in vitro.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; bcl-X Protein; Chelating Agents; Disease Models, Ani | 2005 |
Protective effect of zinc against ischemic neuronal injury in a middle cerebral artery occlusion model.
Topics: Animals; Calcium; Calcium Radioisotopes; Cell Culture Techniques; Cell Survival; Cells, Cultured; Ch | 2006 |