n,n,n',n'-tetrakis(2-pyridylmethyl)ethylenediamine has been researched along with Cancer of Prostate in 7 studies
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine: a zinc ion chelating agent; structure given in first source
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine : An N-substituted diamine that is ethylenediamine in which the four amino hydrogens are replaced by 2-pyridylmethyl groups.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Exogenous Zn(2+) initially reduced prostate cancer cell viability but these effects were transitory and were ineffective at enhancing F10 cytotoxicity." | 1.42 | The cytotoxic and pro-apoptotic activities of the novel fluoropyrimidine F10 towards prostate cancer cells are enhanced by Zn(2+) -chelation and inhibiting the serine protease Omi/HtrA2. ( Balaji, KC; Boyacioglu, O; Gmeiner, WH; Jennings-Gee, J; Stuart, CH, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (42.86) | 29.6817 |
| 2010's | 4 (57.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Makhov, P | 3 |
| Golovine, K | 3 |
| Uzzo, RG | 3 |
| Rothman, J | 1 |
| Crispen, PL | 2 |
| Shaw, T | 1 |
| Scoll, BJ | 1 |
| Kolenko, VM | 3 |
| Gmeiner, WH | 2 |
| Boyacioglu, O | 1 |
| Stuart, CH | 2 |
| Jennings-Gee, J | 1 |
| Balaji, KC | 2 |
| Singh, R | 1 |
| Smith, TL | 1 |
| D'Agostino, R | 1 |
| Caudell, D | 1 |
| Kunkle, D | 1 |
| Carraway, RE | 1 |
| Dobner, PR | 1 |
| Teper, E | 1 |
| Canter, DJ | 1 |
| Myers, CB | 1 |
| Kutikov, A | 1 |
| Sterious, SN | 1 |
| Wong, PF | 1 |
| Abubakar, S | 1 |
7 other studies available for n,n,n',n'-tetrakis(2-pyridylmethyl)ethylenediamine and Cancer of Prostate
| Article | Year |
|---|---|
Zinc chelation induces rapid depletion of the X-linked inhibitor of apoptosis and sensitizes prostate cancer cells to TRAIL-mediated apoptosis.
Topics: Apoptosis; Caspases; Cell Line, Tumor; Chelating Agents; Copper; Drug Screening Assays, Antitumor; E | 2008 |
The cytotoxic and pro-apoptotic activities of the novel fluoropyrimidine F10 towards prostate cancer cells are enhanced by Zn(2+) -chelation and inhibiting the serine protease Omi/HtrA2.
Topics: Apoptosis; Chelating Agents; Ethylenediamines; Fluorodeoxyuridylate; High-Temperature Requirement A | 2015 |
Prostate-specific membrane antigen-targeted liposomes specifically deliver the Zn(2+) chelator TPEN inducing oxidative stress in prostate cancer cells.
Topics: Animals; Antigens, Surface; Aptamers, Nucleotide; Cell Death; Chelating Agents; Drug Delivery System | 2016 |
Depletion of intracellular zinc increases expression of tumorigenic cytokines VEGF, IL-6 and IL-8 in prostate cancer cells via NF-kappaB-dependent pathway.
Topics: Adenocarcinoma; Cation Transport Proteins; Cell Line, Tumor; Chelating Agents; Ethylenediamines; Hum | 2008 |
Zinc pyrithione induces ERK- and PKC-dependent necrosis distinct from TPEN-induced apoptosis in prostate cancer cells.
Topics: Adenosine Triphosphate; Adenylate Kinase; Antioxidants; Apoptosis; Caspase 3; Caspase 7; Cell Line, | 2012 |
The effect of 5-aminolevulinic acid and its derivatives on protoporphyrin IX accumulation and apoptotic cell death in castrate-resistant prostate cancer cells.
Topics: Aminolevulinic Acid; Apoptosis; Cell Line, Tumor; Chelating Agents; Ethylenediamines; Humans; Male; | 2012 |
High intracellular Zn2+ ions modulate the VHR, ZAP-70 and ERK activities of LNCaP prostate cancer cells.
Topics: Animals; Cell Line, Tumor; Cell Proliferation; Chelating Agents; Culture Media; Dual Specificity Pho | 2008 |