n,n,n',n'-tetrakis(2-pyridylmethyl)ethylenediamine has been researched along with Brain Ischemia in 5 studies
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine: a zinc ion chelating agent; structure given in first source
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine : An N-substituted diamine that is ethylenediamine in which the four amino hydrogens are replaced by 2-pyridylmethyl groups.
Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Our findings reveal a novel mechanism of cerebral ischemia-induced BBB damage, and implicate zinc as an effective and viable new target for reducing acute BBB damage following ischemic stroke." | 1.43 | Zinc contributes to acute cerebral ischemia-induced blood-brain barrier disruption. ( Dong, W; Ji, X; Liang, J; Liu, KJ; Luo, Y; Pan, R; Qi, Z; Shen, J; Shi, W; Yang, Y; Zhao, Y, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 4 (80.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhao, Y | 3 |
| Yan, F | 2 |
| Yin, J | 2 |
| Pan, R | 3 |
| Shi, W | 2 |
| Qi, Z | 3 |
| Fang, Y | 1 |
| Huang, Y | 1 |
| Li, S | 2 |
| Luo, Y | 3 |
| Ji, X | 3 |
| Liu, KJ | 3 |
| Yan, Y | 1 |
| Wang, WM | 1 |
| Liu, Z | 1 |
| Liu, AJ | 1 |
| Wang, YX | 1 |
| Wang, HG | 1 |
| An, D | 1 |
| Heng, B | 1 |
| Xie, LH | 1 |
| Duan, JL | 1 |
| Liu, YQ | 1 |
| Liang, J | 1 |
| Dong, W | 1 |
| Shen, J | 1 |
| Yang, Y | 1 |
| Bonanni, L | 1 |
| Chachar, M | 1 |
| Jover-Mengual, T | 1 |
| Li, H | 1 |
| Jones, A | 1 |
| Yokota, H | 1 |
| Ofengeim, D | 1 |
| Flannery, RJ | 1 |
| Miyawaki, T | 1 |
| Cho, CH | 1 |
| Polster, BM | 1 |
| Pypaert, M | 1 |
| Hardwick, JM | 1 |
| Sensi, SL | 1 |
| Zukin, RS | 1 |
| Jonas, EA | 1 |
5 other studies available for n,n,n',n'-tetrakis(2-pyridylmethyl)ethylenediamine and Brain Ischemia
| Article | Year |
|---|---|
Synergistic Interaction Between Zinc and Reactive Oxygen Species Amplifies Ischemic Brain Injury in Rats.
Topics: Animals; Antioxidants; Apoptosis; Biphenyl Compounds; Brain; Brain Ischemia; Chelating Agents; Ethyl | 2018 |
Chelating intracellularly accumulated zinc decreased ischemic brain injury through reducing neuronal apoptotic death.
Topics: Animals; Apoptosis; Brain Ischemia; Chelating Agents; Cytosol; Ethylenediamines; Infarction, Middle | 2014 |
The Zinc Ion Chelating Agent TPEN Attenuates Neuronal Death/apoptosis Caused by Hypoxia/ischemia Via Mediating the Pathophysiological Cascade Including Excitotoxicity, Oxidative Stress, and Inflammation.
Topics: Animals; Apoptosis; Brain; Brain Ischemia; Cell Hypoxia; Chelating Agents; Disease Models, Animal; E | 2015 |
Zinc contributes to acute cerebral ischemia-induced blood-brain barrier disruption.
Topics: Animals; Blood-Brain Barrier; Brain Ischemia; Ethylenediamines; Infarction, Middle Cerebral Artery; | 2016 |
Zinc-dependent multi-conductance channel activity in mitochondria isolated from ischemic brain.
Topics: Animals; Blotting, Western; Brain Ischemia; Caspases; Chelating Agents; Diagnostic Imaging; Dose-Res | 2006 |