n,n,n',n'-tetrakis(2-pyridylmethyl)ethylenediamine has been researched along with Acute Lymphoid Leukemia in 3 studies
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine: a zinc ion chelating agent; structure given in first source
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine : An N-substituted diamine that is ethylenediamine in which the four amino hydrogens are replaced by 2-pyridylmethyl groups.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Acute lymphoblastic leukemia (ALL) is hematological neoplasia that affects human beings from early life to adulthood." | 1.72 | TPEN/TPGS (T2) combo dramatically reduces Philadelphia chromosome-positive pro-lymphoblastic B leukemia in BALB/c mice. ( Jimenez-Del-Rio, M; Mendivil-Perez, M; Velez-Pardo, C, 2022) |
| "Acute lymphoblastic leukemia is still an incurable disease with resistance to therapy developing in the majority of patients." | 1.38 | TPEN induces apoptosis independently of zinc chelator activity in a model of acute lymphoblastic leukemia and ex vivo acute leukemia cells through oxidative stress and mitochondria caspase-3- and AIF-dependent pathways. ( Jimenez-Del-Rio, M; Mendivil-Perez, M; Velez-Pardo, C, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 2 (66.67) | 2.80 |
| Authors | Studies |
|---|---|
| Mendivil-Perez, M | 3 |
| Velez-Pardo, C | 3 |
| Quiroz-Duque, LM | 1 |
| Restrepo-Rincon, A | 1 |
| Valencia-Zuluaga, NA | 1 |
| Jimenez-Del-Rio, M | 3 |
3 other studies available for n,n,n',n'-tetrakis(2-pyridylmethyl)ethylenediamine and Acute Lymphoid Leukemia
| Article | Year |
|---|---|
TPEN selectively eliminates lymphoblastic B cells from bone marrow pediatric acute lymphoblastic leukemia patients.
Topics: Antigens, CD19; Bone Marrow; Child; Ethylenediamines; Humans; Hydrogen Peroxide; Immunophenotyping; | 2022 |
TPEN/TPGS (T2) combo dramatically reduces Philadelphia chromosome-positive pro-lymphoblastic B leukemia in BALB/c mice.
Topics: Adult; Animals; Fusion Proteins, bcr-abl; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; | 2022 |
TPEN induces apoptosis independently of zinc chelator activity in a model of acute lymphoblastic leukemia and ex vivo acute leukemia cells through oxidative stress and mitochondria caspase-3- and AIF-dependent pathways.
Topics: Acetylcysteine; Apoptosis; Apoptosis Inducing Factor; Caspase 3; Cell Nucleus; Chelating Agents; Chr | 2012 |