n,n-dimethylarginine has been researched along with Disease Models, Animal in 90 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 23 (25.56) | 29.6817 |
| 2010's | 62 (68.89) | 24.3611 |
| 2020's | 5 (5.56) | 2.80 |
| Authors | Studies |
|---|---|
| Braisted, J; Dranchak, P; Earnest, TW; Gu, X; Hoon, MA; Inglese, J; Oliphant, E; Solinski, HJ | 1 |
| Abrams, RPM; Bachani, M; Balasubramanian, A; Brimacombe, K; Dorjsuren, D; Eastman, RT; Hall, MD; Jadhav, A; Lee, MH; Li, W; Malik, N; Nath, A; Padmanabhan, R; Simeonov, A; Steiner, JP; Teramoto, T; Yasgar, A; Zakharov, AV | 1 |
| Chen, YC; Hsiao, CC; Hsu, MH; Huang, LT; Sheen, JM; Wang, SC | 1 |
| Hu, W; Liu, T; Ma, Q; Wang, W; Zhang, J | 1 |
| Huang, D; Tan, B; Wang, C; Wang, Y; Wu, M; Ye, C; Yuan, M; Zou, Y | 1 |
| López, V; Moraga, FA; Uribe, E | 1 |
| Hsu, CN; Tain, YL | 1 |
| Cao, J; Lei, T; Liu, S; Lu, Z; Shi, L; Wang, H; Zhao, C | 1 |
| Atzler, D; Böger, RH; Chen, P; Chen, Y; Fassett, J; Guo, H; Hu, X; Kwak, D; Liu, X; Lu, Z; Schwedhelm, E; Wang, H; Xu, X; Yue, W; Zhang, P | 1 |
| Černe, D; Drevenšek, G; France Štiglic, A; Janić, M; Jerin, A; Lunder, M; Marc, J; Šabovič, M; Skitek, M | 1 |
| Coskun, CN; Demirel-Yilmaz, E; Savci, V; Usanmaz, SE | 1 |
| Lu, XY; Sui, GG; Sun, ZL; Xiao, HB | 1 |
| Abbott, M; Abdi, M; Chauhan, N; Chin, M; Fucci, QA; Halim, A; Handy, DE; Lim, K; Loscalzo, J; Lu, TS; Mistri, M; Pang, P; Proctor, B; Siedlecki, AM; Wang, B; Yin, W | 1 |
| Eringa, EC; Gam, Z; Hoenderop, JG; Juni, RP; Kwekkeboom, RFJ; Richards, WG; Ter Wee, PM; van Loon, EPM; van Poelgeest, EM; Verkaik, M; Vervloet, MG | 1 |
| Barančík, M; Berenyiová, A; Dovinová, I; Hrabárová, E; Jansen, E; Kvandová, M; Majzúnová, M | 1 |
| Chlopicki, S; Jasztal, A; Kij, A; Kus, K; Stojak, M; Walczak, M; Zakrzewska, A | 1 |
| Fujisawa, Y; Gohda, T; Horikoshi, S; Kobayashi, T; Nishiyama, A; Shiota, S; Sugaya, T; Suzuki, Y; Takahashi, K; Ueda, S | 1 |
| He, H; Jiang, H; Li, X; Liu, X; Liu, Y; Wang, H; Wang, S; Yuan, L; Zhang, W | 1 |
| Bedir, YK; Caliskan, G; Can, MM; Kankaya, Y; Karaaslan, O; Silistreli, OK; Sonmez, E | 1 |
| Casella-Filho, A; Chagas, AC; da-Luz, PL; Dourado, PM; Landim, MB | 1 |
| Betz, B; Böger, RH; Kniepert, J; Kress, T; Möller-Ehrlich, K; Sauvant, C; Schneider, R; Schwedhelm, E; Wanner, C | 1 |
| Cooke, JP; Erlanson, DA; Ghebremariam, YT; Lee, JC; Leiper, J; LePendu, P; Shah, NH; Slaviero, A | 1 |
| Guo, YY; Hage, FG; Hilgers, RH; Pacurari, M; Xing, D; Yang, Z | 1 |
| Han, X; Liu, WH; Yin, DX; Zhang, DL; Zhang, QD | 1 |
| Aggarwal, S; Black, SM; Bogatcheva, NV; Catravas, JD; Dimitropoulou, C; Gorshkov, BA; Gross, CM; Jezierska-Drutel, AJ; Kumar, S; Lu, Q; Lucas, R; Sharma, S; Sridhar, S; Verin, AD | 1 |
| Chen, YC; Huang, LT; Sheen, JM; Tain, YL | 1 |
| Arend, M; Cordasic, N; Hilgers, KF; Jacobi, J; Maas, R | 1 |
| Bode-Böger, SM; Brilloff, S; Hohenstein, B; Jabs, N; Jarzebska, N; Kittel, A; Maas, R; Martens-Lobenhoffer, J; Rodionov, RN; Weiss, N | 1 |
| Berardo, C; Bianchi, A; Di Pasqua, LG; Ferrigno, A; Richelmi, P; Rizzo, V; Vairetti, M | 1 |
| Baylis, C; Cunningham, MW; Sasser, JM | 1 |
| Dai, G; Liu, J; Liu, YK; Wang, X; Wang, Y; Xu, Q; Xu, X; Zhang, J; Zhang, W | 1 |
| Andreola, F; Davies, N; De Chiara, F; Garcia-Martinez, R; Habtesion, A; Jalan, R; Jover, M; Macnaughtan, J; Mehta, G; Mookerjee, RP; Oria, M; Poulton, K; Soeda, J | 1 |
| He, X; Ji, Y; Lei, T; Liu, Q; Tian, W; Wang, G; Wang, Y; Xu, H; Zhao, D | 1 |
| Lu, Z; Luo, Y; Quan, X; Wang, Y; Yue, W; Zhao, B | 1 |
| Borderie, D; Bos, C; Huneau, JF; Magné, J; Mariotti, F; Mathé, V | 1 |
| Blandini, F; Demartini, C; Ferrigno, A; Greco, R; Mangione, AS; Nappi, G; Tassorelli, C; Vairetti, M; Zanaboni, A | 1 |
| Black, SM; Desai, AA; Fineman, JR; Fratz, S; Garcia, JG; Jacobson, JR; Kangath, A; Kellner, M; Klinger, C; Lu, Q; Qu, N; Rafikov, R; Sun, X; Wang, T; Yuan, JX | 1 |
| Cerne, D; Drevensek, G; Janic, M; Jerin, A; Lunder, M; Marc, J; Sabovic, M; Skitek, M | 1 |
| Bai, Y; Cao, R; Chen, Y; Du, G; He, G; Sun, L; Sun, T; Wang, F; Ye, P; Zhang, W; Zhao, R | 1 |
| Arriaza, K; Böger, RH; Brito, J; Klose, H; Leon-Velarde, F; Lüneburg, N; Pena, E; Siques, P | 1 |
| Berardo, C; Croce, AC; Di Pasqua, LG; Ferrigno, A; Richelmi, P; Rizzo, V; Vairetti, M | 1 |
| Chen, HW; Feng, J; Pi, LJ; Wang, J; Zhan, DQ | 1 |
| Bache, RJ; Chen, Y; Fassett, JT; Hu, X; Li, J; Xu, X; Zhang, P; Zhu, G | 1 |
| Atabey, N; Demir, O; Demir, T; Durmus, N; Esen, A; Evcim, S; Gidener, S; Irer, B; Kahraman, E; Soner, BC; Toylu, A | 1 |
| Arning, E; Bottiglieri, T; Cooke, JP; Dayal, S; Faraci, FM; Kimoto, M; Lentz, SR; Murry, DJ; Rodionov, RN | 1 |
| Fukami, K; Hayashida, A; Kaida, Y; Kato, S; Kimoto, M; Matsumoto, Y; Matsuoka, H; Okuda, S; Shibata, R; Ueda, S; Yamagishi, S | 1 |
| Fujimi-Hayashida, A; Fukami, K; Kaida, Y; Koike, K; Matsumoto, Y; Okuda, S; Tanaka, H; Ueda, S; Yamagishi, S | 1 |
| Banday, AA; Lokhandwala, MF | 1 |
| Böger, R; Lüneburg, N; Maas, R | 1 |
| Barbaros, B; Filiz, B; Gonca, O; Halil, Y; Nihal, S; Nurten, T; Ozgür, A | 1 |
| Jiang, H; Li, Y; Lin, G; Zeng, H; Zhao, A | 1 |
| Chen, CC; Hsieh, CS; Huang, LT; Lee, CT; Sheen, JM; Tain, YL | 1 |
| Li, L; Liu, YZ; Luo, XJ; Peng, J; Tan, N; Xiang, DX; Yuan, Q; Zhang, YS | 1 |
| Agrawal, A; Ahmad, T; Aich, J; Ghosh, B; Mabalirajan, U; Makhija, L; Sharma, A | 1 |
| Black, SM; Catravas, JD; Fineman, JR; Fratz, S; Haag, S; Hess, J; Hou, Y; Kumar, S; Naumann, S; Patterson, C; Rafikov, R; Rehmani, I; Reiser, J; Schreiber, C; Sharma, S; Smith, A; Sun, X; Tian, J | 1 |
| Buford, MC; Holian, A; Klein, E; Weigel, J; Wells, SM | 1 |
| Bode-Böger, SM; Bukowska, A; Dobrev, D; Goette, A; Hammwöhner, M; Lendeckel, U; Martens-Lobenhoffer, J; Medunjanin, S; Ravens, U; Scalera, F; Weinert, S | 1 |
| Horowitz, JD; Kelly, DJ; Kennedy, JA; Ngo, DT; Qi, W; Smith, MD; Stafford, I; Sverdlov, AL; Weedon, H; Wuttke, RD; Zhang, Y | 1 |
| Collin, B; Cottin, Y; Duvillard, L; Goirand, F; Guilland, JC; Korandji, C; Lauzier, B; Moreau, D; Rochette, L; Sicard, P; Vergely, C; Zeller, M | 1 |
| Akgul, EO; Aydin, I; Bilgi, C; Cakir, E; Cayci, T; Ceyhan, TS; Erbil, KM; Kurt, YG; Onguru, O; Yaman, H; Yasar, M | 1 |
| Aizawa, K; Ishizuka, N; Iwabuchi, S; Kitamura, H; Moriguchi, Y; Nishimura, T; Serizawa, K; Tashiro, Y; Yogo, K; Yorozu, K | 1 |
| Baumbach, G; Bengrine, A; Bode-Boeger, SM; Bugnicourt, JM; Chillon, JM; Da Silveira, C; Godefroy, O; Kielstein, JT; Massy, ZA; Sevestre, H | 1 |
| Galvano, F; Li Volti, G; Mangiameli, A; Salamone, F; Salomone, S; Siarkos, I; Sorrenti, V; Urso, V | 1 |
| Dugas, TR; Foley, JD; Hebert, VY; Kleinedler, JJ; Orchard, EA; Rogers, LK | 1 |
| Wilcox, CS | 1 |
| Anegawa, T; Aoki, H; Aoki, Y; Imaizumi, T; Kai, H; Kajimoto, H; Okuda, S; Ueda, S; Yasuoka, S | 1 |
| Dalton, RN; Davies, NA; Deutz, NE; Jalan, R; Mookerjee, RP; Revhaug, A; Rose, CF; Sen, S; Sharma, V; Ten Have, GA; Turner, C; van-Eijk, HM; Ytrebo, L | 1 |
| Billecke, S; Chen, AF; Craig, T; D'Alecy, LG; Haywood, JR; Hinojosa-Laborde, C; Northcott, CA; Patel, KP | 1 |
| Kimura, K | 1 |
| Aramburo, A; Black, SM; Fineman, JR; Kalkan, G; Kallarackal, S; Kumar, S; Rafikov, R; Rehmani, I; Sharma, S; Sun, X; Tian, J | 1 |
| Ando, R; Fukami, K; Iwatani, R; Kaida, Y; Nakayama, Y; Okuda, S; Ueda, S; Yamagishi, S | 1 |
| Atli, O; Demirel-Yilmaz, E; Ilgin, S; Sirmagul, B; Usanmaz, SE | 1 |
| Aggarwal, S; Black, SM; Burns, T; Dasarathy, S; Fineman, JR; Fratz, S; Kumar, S; Lu, Q; Radman, M; Rafikov, R; Rafikova, O; Schreiber, C; Sharma, S; Sun, X; Wright, J | 1 |
| Chen, CC; Huang, LT; Kao, YH; Lee, CT; Sheen, JM; Tain, YL; Yu, HR | 1 |
| Carey, RM; Johns, RA; Leiper, JM; Li, D; Millatt, LJ; Siragy, HM; Whitley, GS | 1 |
| Cooke, JP | 1 |
| Böger, RH | 1 |
| Dai, Z; Deng, HW; Jiang, DJ; Jiang, JL; Li, YJ; Zhu, HQ | 1 |
| Espey, MG; Harvey-White, J; Iuliano, BA; Jung, CS; Oldfield, EH; Pluta, RM | 1 |
| Aigner, C; Fink, L; Ghofrani, HA; Grimminger, F; Haredza, P; Kiss, L; Klepetko, W; Muyal, JP; Pullamsetti, S; Schermuly, RT; Seeger, W; Voswinckel, R; Weissmann, N | 1 |
| Achan, V; Cooke, JP; Heeschen, C; Ho, HK; Jang, JJ; Kimoto, M; Stuehlinger, M; Vallance, P | 1 |
| Dayal, S; Lentz, SR | 1 |
| Maas, R | 1 |
| Cooke, JP; Konishi, H; Sydow, K | 1 |
| Branzi, A; Coccolo, F; Cooke, JP; Fallani, F; Ferrara, R; Grigioni, F; Lewis, DB; Magelli, C; Magnani, G; Mocarski, ES; Potena, L; Valantine, HA | 1 |
| Fukami, K; Imaizumi, T; Matsuguma, K; Matsumoto, Y; Matsuoka, H; Okuda, S; Shibata, R; Ueda, S; Yamagishi, S | 1 |
| Brown, RD; Carlström, M; Edlund, J; Larsson, E; Palm, F; Persson, AE; Sällström, J; Teerlink, T; Wåhlin, N | 1 |
| Lentz, SR; Rodionov, RN | 1 |
| Henrion, D; Lévy, BI; Loufrani, L; Matrougui, K | 1 |
| Azuma, H; Goto, M; Kihara, K; Masuda, H; Okuno, T; Tsujii, T | 1 |
11 review(s) available for n,n-dimethylarginine and Disease Models, Animal
| Article | Year |
|---|---|
Activation of arginase II by asymmetric dimethylarginine and homocysteine in hypertensive rats induced by hypoxia: a new model of nitric oxide synthesis regulation in hypertensive processes?
Topics: Animals; Arginase; Arginine; Disease Models, Animal; Homocysteine; Hypertension; Hypoxia; Nitric Oxide; Rats; Rats, Wistar | 2021 |
Interplay between Oxidative Stress and Nutrient Sensing Signaling in the Developmental Origins of Cardiovascular Disease.
Topics: Animals; Arginine; Cardiovascular Diseases; Disease Models, Animal; Energy Metabolism; Humans; Nitric Oxide; Nutritional Physiological Phenomena; Oxidative Stress; Reactive Oxygen Species; Signal Transduction | 2017 |
Increased circulatory asymmetric dimethylarginine and multiple organ failure: bile duct ligation in rat as a model.
Topics: Animals; Arginine; Bile Ducts; Disease Models, Animal; Fibrosis; Ligation; Liver; Liver Cirrhosis; Multiple Organ Failure; Rats | 2014 |
ADMA and the role of the genes: lessons from genetically modified animals and human gene polymorphisms.
Topics: Animals; Animals, Genetically Modified; Arginine; Disease Models, Animal; Humans; Polymorphism, Genetic | 2009 |
Asymmetric dimethylarginine and reactive oxygen species: unwelcome twin visitors to the cardiovascular and kidney disease tables.
Topics: Animals; Arginine; Cardiovascular Diseases; Disease Models, Animal; Endothelium, Vascular; Humans; Kidney Diseases; Rats; Reactive Oxygen Species; Risk Factors | 2012 |
[Methylarginies-induced endothelial dysfunction in chronic kidney disease].
Topics: Animals; Arginine; Cardiovascular Diseases; Disease Models, Animal; Endothelium, Vascular; Enzyme Inhibitors; Humans; Nitric Oxide; Nitric Oxide Synthase Type III; Renal Insufficiency, Chronic; Risk Factors | 2012 |
A novel mechanism for pulmonary arterial hypertension?
Topics: Amidohydrolases; Animals; Arginine; Disease Models, Animal; Humans; Hypertension, Pulmonary; Mice; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Pulmonary Artery; Rats; Vasomotor System | 2003 |
[Asymmetrical methylarginine (ADMA) as a cardiovascular risk factor: epidemiological and prospective data].
Topics: Adult; Aged; Aged, 80 and over; Animals; Arginine; Arteriosclerosis; Biomarkers; Cardiovascular Diseases; Case-Control Studies; Cells, Cultured; Child; Coronary Disease; Diabetes Mellitus, Type 2; Disease Models, Animal; Endothelial Cells; Enzyme-Linked Immunosorbent Assay; Female; Free Radicals; Humans; Hypertension; Kidney Failure, Chronic; Male; Middle Aged; Multicenter Studies as Topic; Multivariate Analysis; Nitric Oxide Synthase; Oxidative Stress; Pre-Eclampsia; Pregnancy; Prospective Studies; Rabbits; Regression Analysis; Renal Dialysis; Risk Factors; Stroke | 2004 |
ADMA and hyperhomocysteinemia.
Topics: Amidohydrolases; Animals; Arginine; Cardiovascular Diseases; Disease Models, Animal; Endothelium, Vascular; Enzyme Inhibitors; Homocysteine; Humans; Hyperhomocysteinemia; Nitric Oxide; Nitric Oxide Synthase Type III; Risk Factors; Superoxides; Vasodilation | 2005 |
Pharmacotherapies and their influence on asymmetric dimethylargine (ADMA).
Topics: Amidohydrolases; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Arginine; Biomarkers; Cardiovascular Diseases; Clinical Trials as Topic; Disease Models, Animal; Drug Evaluation, Preclinical; Endothelium, Vascular; Enzyme Inhibitors; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperhomocysteinemia; Nitric Oxide; Nitric Oxide Synthase; Protein-Arginine N-Methyltransferases; Renal Insufficiency | 2005 |
[Coronary allograft vasculopathy: pathophysiological interaction between the immune system, infections and metabolic syndrome].
Topics: Animals; Arginine; Clinical Trials as Topic; Coronary Disease; Cytomegalovirus Infections; Disease Models, Animal; Endothelium, Vascular; Graft Rejection; Graft Survival; Heart Transplantation; Humans; Hypolipidemic Agents; Immunosuppression Therapy; Immunosuppressive Agents; Metabolic Syndrome; Quality of Life; Risk Assessment; Risk Factors; Rodentia; Stents; Time Factors | 2007 |
79 other study(ies) available for n,n-dimethylarginine and Disease Models, Animal
| Article | Year |
|---|---|
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, Spinal; Humans; Mice, Inbred C57BL; Mice, Knockout; Neurons; Pruritus; Receptors, Atrial Natriuretic Factor; Reproducibility of Results; Signal Transduction; Small Molecule Libraries | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Immunocompetence; Inhibitory Concentration 50; Methacycline; Mice, Inbred C57BL; Protease Inhibitors; Quantitative Structure-Activity Relationship; Small Molecule Libraries; Vero Cells; Zika Virus; Zika Virus Infection | 2020 |
Melatonin rescued methotrexate-induced spatial deficit and hyperhomocysteinemia and increased asymmetric dimethylarginine in plasma and dorsal hippocampus in developing rats.
Topics: Animals; Animals, Newborn; Antimetabolites, Antineoplastic; Arginine; Disease Models, Animal; Hippocampus; Hyperhomocysteinemia; Male; Maze Learning; Melatonin; Methotrexate; Rats; Rats, Sprague-Dawley; Spatial Behavior | 2020 |
Blueberry anthocyanin‑enriched extract ameliorates transverse aortic constriction‑induced myocardial dysfunction via the DDAH1/ADMA/NO signaling pathway in mice.
Topics: Amidohydrolases; Animals; Anthocyanins; Aortic Valve Stenosis; Apoptosis; Arginine; Blueberry Plants; Cardiovascular Diseases; Disease Models, Animal; Gene Expression Regulation; Humans; Mice; Myocytes, Cardiac; Nitric Oxide; Oxidative Stress; Plant Extracts; Signal Transduction | 2020 |
Renal asymmetric dimethylarginine inhibits fibrosis.
Topics: Amidohydrolases; Animals; Arginine; Disease Models, Animal; Fibronectins; Fibrosis; Kidney; Kidney Diseases; Male; Mice; Mice, Inbred C57BL; Renal Insufficiency, Chronic; Ureteral Obstruction | 2020 |
Dimethylarginine Dimethylaminohydrolase 1 Deficiency Induces the Epithelial to Mesenchymal Transition in Renal Proximal Tubular Epithelial Cells and Exacerbates Kidney Damage in Aged and Diabetic Mice.
Topics: Aging; Aldosterone; Amidohydrolases; Animals; Arginine; Cell Line; Creatinine; Diabetes Mellitus, Experimental; Disease Models, Animal; Epithelial Cells; Epithelial-Mesenchymal Transition; Fibrosis; Gene Knockout Techniques; Humans; Kidney Diseases; Kidney Tubules, Proximal; Mice | 2017 |
Cardiomyocyte dimethylarginine dimethylaminohydrolase-1 (DDAH1) plays an important role in attenuating ventricular hypertrophy and dysfunction.
Topics: Amidohydrolases; Animals; Arginine; Atrial Natriuretic Factor; Disease Models, Animal; Fibrosis; Genetic Predisposition to Disease; Hypertrophy, Left Ventricular; Male; Mice, Knockout; Myocytes, Cardiac; Nitric Oxide; Phenotype; Signal Transduction; Tyrosine; Ventricular Dysfunction, Left; Ventricular Function, Left; Ventricular Remodeling | 2017 |
Sub-therapeutic doses of fluvastatin and valsartan are more effective than therapeutic doses in providing beneficial cardiovascular pleiotropic effects in rats: A proof of concept study.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Aorta, Thoracic; Arginine; Blood Pressure; Cholesterol; Coronary Circulation; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Fatty Acids, Monounsaturated; Female; Fluvastatin; Heart; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Indoles; Male; Myocardial Reperfusion Injury; Myocardium; Nitric Oxide; Nitric Oxide Synthase Type III; Rats, Wistar; Receptor, Endothelin A; Time Factors; Valsartan; Vasodilation | 2017 |
Time-Dependent Production of Endothelium-Related Biomarkers is Affected Differently in Hemorrhagic and Septic Shocks.
Topics: Animals; Antioxidants; Arginine; Biomarkers; Blood Pressure; Disease Models, Animal; Endothelial Cells; Hydrogen Sulfide; Male; Nitric Oxide; Rats, Wistar; Resuscitation; Shock, Hemorrhagic; Shock, Septic; Time Factors | 2018 |
Elevated Levels of ADMA Are Associated with Lower DDAH2 and Higher PRMT1 in LPS-Induced Endometritis Rats.
Topics: Amidohydrolases; Animals; Arginine; Dinoprost; Disease Models, Animal; Down-Regulation; Endometriosis; Female; Interleukin-6; Lipopolysaccharides; Peroxidase; Protein-Arginine N-Methyltransferases; Rats, Wistar; Reactive Oxygen Species; Tumor Necrosis Factor-alpha; Up-Regulation; Uterus | 2018 |
Pre-clinical model of severe glutathione peroxidase-3 deficiency and chronic kidney disease results in coronary artery thrombosis and depressed left ventricular function.
Topics: Animals; Arginine; Disease Models, Animal; Glutathione Peroxidase; Heart Diseases; Mice; Mice, Knockout; Platelet Aggregation; Reactive Oxygen Species; Renal Insufficiency, Chronic; Thrombosis; Ventricular Dysfunction, Left | 2018 |
FGF23 impairs peripheral microvascular function in renal failure.
Topics: Animals; Arginine; Cells, Cultured; Coronary Circulation; Coronary Vessels; Disease Models, Animal; Endothelial Cells; Fibroblast Growth Factor-23; Fibroblast Growth Factors; Gracilis Muscle; Humans; Kidney; Male; Mice, Inbred C57BL; Microcirculation; Microvessels; Renal Insufficiency, Chronic; Signal Transduction; Vascular Resistance; Vasodilation; Vasodilator Agents | 2018 |
ADMA, homocysteine and redox status improvement affected by 7-nitroindazole in spontaneously hypertensive rats.
Topics: Animals; Aorta; Arginine; Biomarkers; Disease Models, Animal; Enzyme Inhibitors; Heart Ventricles; Homocysteine; Hypertension; Indazoles; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Oxidation-Reduction; Rats, Inbred SHR | 2018 |
Alterations in arginine and energy metabolism, structural and signalling lipids in metastatic breast cancer in mice detected in plasma by targeted metabolomics and lipidomics.
Topics: Animals; Arginase; Arginine; Biomarkers, Tumor; Breast Neoplasms; Cell Line, Tumor; Chromatography, High Pressure Liquid; Disease Models, Animal; Energy Metabolism; Female; Humans; Lipid Metabolism; Lipids; Metabolomics; Mice; Mice, Inbred BALB C; Neoplasm Staging; Polyamines; Tandem Mass Spectrometry | 2018 |
Chronic intermittent hypoxia-mediated renal sympathetic nerve activation in hypertension and cardiovascular disease.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Angiotensins; Animals; Arginine; Cardiovascular Diseases; Deoxyguanosine; Disease Models, Animal; Humans; Hypertension; Hypoxia; Kidney; Male; Mice; Mice, Inbred C57BL; Norepinephrine; Oxidative Stress; Sympathectomy; Sympathetic Nervous System | 2018 |
Effects of salvianolic acid A on plasma and tissue dimethylarginine levels in a rat model of myocardial infarction.
Topics: Amidohydrolases; Animals; Arginine; Caffeic Acids; Chromatography, High Pressure Liquid; Creatinine; Disease Models, Animal; Heart Ventricles; Kidney; Lactates; Liver; Male; Myocardial Infarction; Proton Pump Inhibitors; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry | 2013 |
Monitorization of asymmetric dimethylarginine (ADMA) levels in an experimental ischemia-reperfusion flap model: a preliminary report.
Topics: Abdominal Muscles; Animals; Arginine; Disease Models, Animal; Graft Rejection; Graft Survival; Male; Monitoring, Physiologic; Nitric Oxide; Nitric Oxide Synthase; Postoperative Period; Preoperative Period; Random Allocation; Rats; Rats, Wistar; Reference Values; Reperfusion Injury; Risk Factors; Skin Transplantation; Statistics, Nonparametric; Surgical Flaps | 2013 |
High plasma concentrations of asymmetric dimethylarginine inhibit ischemic cardioprotection in hypercholesterolemic rats.
Topics: Animals; Arginine; Cholesterol; Cholesterol, Dietary; Disease Models, Animal; Hypercholesterolemia; Ischemic Preconditioning, Myocardial; Male; Myocardial Infarction; Rats; Rats, Wistar | 2013 |
Increased symmetrical dimethylarginine in ischemic acute kidney injury as a causative factor of renal L-arginine deficiency.
Topics: Acute Kidney Injury; Amidohydrolases; Animals; Arginine; Blotting, Western; Chromatography, High Pressure Liquid; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Female; Intracellular Signaling Peptides and Proteins; Kidney; Kidney Function Tests; Protein-Arginine N-Methyltransferases; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Reperfusion Injury; Tandem Mass Spectrometry | 2013 |
Unexpected effect of proton pump inhibitors: elevation of the cardiovascular risk factor asymmetric dimethylarginine.
Topics: Amidohydrolases; Animals; Arginine; Biomarkers; Cardiovascular Diseases; Cells, Cultured; Disease Models, Animal; Endothelium, Vascular; Esomeprazole; Gastroesophageal Reflux; Humans; Lansoprazole; Male; Mice; Mice, Inbred C57BL; Nitric Oxide Synthase Type III; Proton Pump Inhibitors; Risk Factors; Vasodilation | 2013 |
Endothelial cell transfusion ameliorates endothelial dysfunction in 5/6 nephrectomized rats.
Topics: Acetylcholine; Amidohydrolases; Animals; Aorta; Arginine; Disease Models, Animal; Endothelial Cells; Endothelium, Vascular; Male; Mesenteric Arteries; Myography; Nephrectomy; Nitric Oxide Synthase Type III; Rats; Rats, Sprague-Dawley; Renal Insufficiency, Chronic; Vasodilation; Vasodilator Agents | 2013 |
Apelin-13 deteriorates hypertension in rats after damage of the vascular endothelium by ADMA.
Topics: Animals; Arginine; Blood Pressure; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelin-1; Endothelium, Vascular; Hypertension; Injections, Intravenous; Intercellular Signaling Peptides and Proteins; Male; Myosin Light Chains; Nitric Oxide; Phosphorylation; Rats; Rats, Sprague-Dawley; Time Factors; Vasoconstriction; Vasodilation; von Willebrand Factor | 2013 |
Dimethylarginine dimethylaminohydrolase II overexpression attenuates LPS-mediated lung leak in acute lung injury.
Topics: Acute Lung Injury; Amidohydrolases; Animals; Arginine; Bronchoalveolar Lavage Fluid; Capillary Permeability; Cells, Cultured; Disease Models, Animal; Endothelial Cells; Genetic Therapy; Humans; Lipopolysaccharides; Lung; Male; Mice; Mice, Inbred C57BL; Microvessels; Oxidative Stress; Peroxynitrous Acid; Pulmonary Edema; Superoxides; Time Factors; Transfection; Up-Regulation | 2014 |
Effect of lowering asymmetric dimethylarginine (ADMA) on vascular pathology in atherosclerotic ApoE-deficient mice with reduced renal mass.
Topics: Amidohydrolases; Animals; Aorta; Apolipoproteins E; Arginine; Atherosclerosis; Disease Models, Animal; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nephrectomy; Nitric Oxide Synthase; Plaque, Atherosclerotic; Renal Insufficiency, Chronic; Transaminases | 2014 |
Role of alanine:glyoxylate aminotransferase 2 in metabolism of asymmetric dimethylarginine in the settings of asymmetric dimethylarginine overload and bilateral nephrectomy.
Topics: Acute Kidney Injury; Alanine; Animals; Arginine; Biomarkers; Blotting, Western; Disease Models, Animal; Enzyme Inhibitors; Gene Expression Regulation; Infusions, Intravenous; Male; Metabolic Networks and Pathways; Mice; Mice, Inbred C57BL; Nephrectomy; Real-Time Polymerase Chain Reaction; RNA; Transaminases | 2014 |
Changes in ADMA/DDAH pathway after hepatic ischemia/reperfusion injury in rats: the role of bile.
Topics: Amidohydrolases; Animals; Arginine; Bile; Cationic Amino Acid Transporter 2; Disease Models, Animal; Liver; Male; Organ Specificity; Oxidative Stress; Protein-Arginine N-Methyltransferases; Rats; Rats, Wistar; Reperfusion Injury | 2014 |
Serelaxin reduces oxidative stress and asymmetric dimethylarginine in angiotensin II-induced hypertension.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Antioxidants; Arginine; Arterial Pressure; Dinoprost; Disease Models, Animal; Down-Regulation; Humans; Hypertension; Injections, Subcutaneous; Kidney; Liver; Male; NADPH Oxidases; Nitric Oxide; Oxidative Stress; Proteinuria; Rats, Sprague-Dawley; Recombinant Proteins; Relaxin; Thiobarbituric Acid Reactive Substances | 2014 |
Cardioprotective effects of oxymatrine on isoproterenol-induced heart failure via regulation of DDAH/ADMA metabolism pathway in rats.
Topics: Alkaloids; Amidohydrolases; Animals; Arginine; Cardiotonic Agents; Disease Models, Animal; Female; Heart Failure; Hemodynamics; Isoproterenol; Male; Metabolic Networks and Pathways; Myocardium; Natriuretic Peptide, Brain; Organ Size; Protein-Arginine N-Methyltransferases; Quinolizines; Rats; Rats, Sprague-Dawley; Troponin I | 2014 |
Immunomodulatory and antioxidant function of albumin stabilises the endothelium and improves survival in a rodent model of chronic liver failure.
Topics: Albumins; Animals; Arginine; Disease Models, Animal; End Stage Liver Disease; Endothelium, Vascular; Hemodynamics; Humans; Inflammation; Nitric Oxide Synthase; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; von Willebrand Factor | 2015 |
Effect of 18β-glycyrrhetinic acid on cerebral vasospasm caused by asymmetric dimethylarginine after experimental subarachnoid hemorrhage in rats.
Topics: Animals; Arginine; Basilar Artery; Blotting, Western; Connexin 43; Connexins; Disease Models, Animal; Glycyrrhetinic Acid; Neuroprotective Agents; Random Allocation; Rats, Sprague-Dawley; Severity of Illness Index; Subarachnoid Hemorrhage; Time Factors; Vasospasm, Intracranial | 2015 |
Asymmetric dimethylarginine exacerbates Aβ-induced toxicity and oxidative stress in human cell and Caenorhabditis elegans models of Alzheimer disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Animals, Genetically Modified; Arginine; Caenorhabditis elegans; Disease Models, Animal; Gene Knockdown Techniques; Humans; MAP Kinase Signaling System; Oxidative Stress; Protein-Arginine N-Methyltransferases; Repressor Proteins | 2015 |
Plasma asymmetric and symmetric dimethylarginine in a rat model of endothelial dysfunction induced by acute hyperhomocysteinemia.
Topics: Amidohydrolases; Animals; Arginine; Cathepsin D; Disease Models, Animal; Endothelium, Vascular; Gene Expression Regulation; Hyperhomocysteinemia; Liver; Male; Methionine; Rats; Rats, Wistar; Ubiquitin | 2015 |
Evaluation of ADMA-DDAH-NOS axis in specific brain areas following nitroglycerin administration: study in an animal model of migraine.
Topics: Amidohydrolases; Animals; Arginine; Brain; Disease Models, Animal; Drug Evaluation, Preclinical; Male; Migraine Disorders; Nitric Oxide Synthase Type I; Nitroglycerin; Rats; Rats, Sprague-Dawley | 2015 |
Asymmetric Dimethylarginine Stimulates Akt1 Phosphorylation via Heat Shock Protein 70-Facilitated Carboxyl-Terminal Modulator Protein Degradation in Pulmonary Arterial Endothelial Cells.
Topics: Animals; Arginine; Carrier Proteins; Disease Models, Animal; Endothelial Cells; Genes, Dominant; HSP70 Heat-Shock Proteins; HSP90 Heat-Shock Proteins; Lung; Mitochondria; Nitric Oxide Synthase Type III; Phosphorylation; Proteasome Endopeptidase Complex; Protein Binding; Proteolysis; Proto-Oncogene Proteins c-akt; Pulmonary Artery; Regional Blood Flow; Sheep; Ubiquitination | 2016 |
The "Rise-Peak-Fall" Pattern of Time Dependency of the Cardiovascular Pleiotropic Effects of Treatment With Low-dose Atorvastatin, Losartan, and a Combination Thereof in Rats.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Aorta, Thoracic; Arginine; Atorvastatin; Cardiovascular System; Carrier Proteins; CD40 Antigens; Coronary Circulation; Disease Models, Animal; Drug Therapy, Combination; Endothelium, Vascular; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Isolated Heart Preparation; Losartan; Male; Myocardial Reperfusion Injury; Myocardium; Nitric Oxide; Nitric Oxide Synthase Type III; Rats, Wistar; Time Factors; Vasodilation | 2016 |
Oncological miR-182-3p, a Novel Smooth Muscle Cell Phenotype Modulator, Evidences From Model Rats and Patients.
Topics: Animals; Arginine; Carotid Artery Diseases; Carotid Artery Injuries; Cell Differentiation; Cell Movement; Cell Proliferation; Cells, Cultured; Coronary Artery Disease; Disease Models, Animal; Dose-Response Relationship, Drug; Extracellular Signal-Regulated MAP Kinases; Gene Expression Profiling; Gene Expression Regulation; Humans; Male; MicroRNAs; Muscle, Smooth, Vascular; Myelin and Lymphocyte-Associated Proteolipid Proteins; Myocytes, Smooth Muscle; Neointima; Oligonucleotide Array Sequence Analysis; Phenotype; Rats, Sprague-Dawley; RNA Interference; Signal Transduction; Transfection; Vascular Remodeling | 2016 |
Long-Term Chronic Intermittent Hypobaric Hypoxia in Rats Causes an Imbalance in the Asymmetric Dimethylarginine/Nitric Oxide Pathway and ROS Activity: A Possible Synergistic Mechanism for Altitude Pulmonary Hypertension?
Topics: Altitude Sickness; Amidohydrolases; Animals; Arginine; Disease Models, Animal; Hypertension, Pulmonary; Hypoxia; Lung; Male; Nitric Oxide; Nitric Oxide Synthase; Oxidative Stress; Pulmonary Circulation; Rats; Rats, Wistar; Signal Transduction; Time Factors; Vascular Resistance | 2016 |
MCD diet-induced steatohepatitis is associated with alterations in asymmetric dimethylarginine (ADMA) and its transporters.
Topics: Amino Acid Transport Systems, Basic; Animals; Arginine; Choline; Disease Models, Animal; Fatty Liver; Gene Expression Regulation; Male; Methionine; Rats; Rats, Wistar | 2016 |
Protective effect of tanshinone IIA against cardiac hypertrophy in spontaneously hypertensive rats through inhibiting the Cys-C/Wnt signaling pathway.
Topics: Abietanes; Animals; Arginine; Cardiomegaly; Cardiovascular Agents; Collagen Type I; Collagen Type I, alpha 1 Chain; Collagen Type III; Cystatin C; Disease Models, Animal; Hypertension; Male; Myocardium; NADPH Oxidase 4; Nitric Oxide; Nitric Oxide Synthase Type III; Phosphorylation; Rats, Inbred SHR; Rats, Inbred WKY; Time Factors; Troponin I; Wnt Signaling Pathway | 2017 |
Repetitive ischemia increases myocardial dimethylarginine dimethylaminohydrolase 1 expression.
Topics: Amidohydrolases; Animals; Arginine; Cell Hypoxia; Cells, Cultured; Collateral Circulation; Coronary Circulation; Coronary Vessels; Disease Models, Animal; Dogs; Endothelial Cells; Humans; Interleukin-1beta; Myocardial Ischemia; Myocardium; Neovascularization, Physiologic; Nitric Oxide Synthase Type II; Protein-Arginine N-Methyltransferases; Signal Transduction; Time Factors; Tumor Necrosis Factor-alpha; Up-Regulation; Vascular Endothelial Growth Factor A | 2017 |
Time-course changes of nLDL-induced erectile dysfunction.
Topics: Animals; Arginine; Disease Models, Animal; Endothelium, Vascular; Erectile Dysfunction; Hyperlipidemias; Lipoproteins, LDL; Male; Nitric Oxide Synthase Type III; Rats, Wistar; Time Factors | 2017 |
Tissue-specific downregulation of dimethylarginine dimethylaminohydrolase in hyperhomocysteinemia.
Topics: Amidohydrolases; Animals; Arginine; Carotid Arteries; Cell Line; Cystathionine beta-Synthase; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Endothelial Cells; Endothelium, Vascular; Folic Acid; Gene Expression Regulation, Enzymologic; Homocysteine; Hyperhomocysteinemia; Liver; Methionine; Methylation; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide; RNA, Messenger; Vasodilation; Vasodilator Agents | 2008 |
Involvement of asymmetric dimethylarginine (ADMA) in tubulointerstitial ischaemia in the early phase of diabetic nephropathy.
Topics: Adenoviridae; Amidohydrolases; Animals; Arginine; Diabetic Nephropathies; Disease Models, Animal; Genetic Vectors; Ischemia; Kidney; Male; Nephritis, Interstitial; Nitric Oxide; Rats; Rats, Sprague-Dawley | 2009 |
Involvement of asymmetric dimethylarginine (ADMA) in glomerular capillary loss and sclerosis in a rat model of chronic kidney disease (CKD).
Topics: Amidohydrolases; Animals; Arginine; Capillaries; Disease Models, Animal; Glomerulosclerosis, Focal Segmental; Humans; Kidney Failure, Chronic; Kidney Glomerulus; Rats | 2009 |
Inhibition of natriuretic factors increases blood pressure in rats.
Topics: Amidohydrolases; Animals; Antioxidants; Arginine; Blood Pressure; Buthionine Sulfoximine; Cyclic N-Oxides; Disease Models, Animal; Dopamine; Hypertension; Kidney Tubules, Proximal; Male; Natriuresis; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidants; Oxidative Stress; Phosphorylation; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Serine; Signal Transduction; Sodium Chloride, Dietary; Sodium-Potassium-Exchanging ATPase; Spin Labels | 2009 |
Role of neutrophils in arginine-asymmetric dimethylarginine pathway subsequent to endotoxemia.
Topics: Animals; Arginine; Disease Models, Animal; Endotoxemia; Guinea Pigs; Lipopolysaccharides; Liver; Male; Neutrophils; Peroxidase; Tyrosine | 2009 |
[Effects of Xuefu Zhuyu decoction on serum asymmetric dimethylarginine in atherosclerosis rabbits].
Topics: Animals; Arginine; Atherosclerosis; Cholesterol; Disease Models, Animal; Drugs, Chinese Herbal; Humans; Male; Rabbits; Random Allocation; Triglycerides | 2009 |
Melatonin prevents increased asymmetric dimethylarginine in young rats with bile duct ligation.
Topics: Amidohydrolases; Analysis of Variance; Animals; Arginine; Bile Ducts; Cholestasis, Intrahepatic; Disease Models, Animal; Immunohistochemistry; Kidney; Liver; Male; Melatonin; Oxidative Stress; Rats; Rats, Sprague-Dawley | 2010 |
The role of the DDAH-ADMA pathway in the protective effect of resveratrol analog BTM-0512 on gastric mucosal injury.
Topics: Amidohydrolases; Animals; Anti-Ulcer Agents; Arginine; Disease Models, Animal; Ethanol; Hydroxyl Radical; Male; Molecular Structure; Nitric Oxide; Rats; Rats, Sprague-Dawley; Resveratrol; Stilbenes; Stomach Ulcer; Superoxides | 2010 |
Simvastatin improves epithelial dysfunction and airway hyperresponsiveness: from asymmetric dimethyl-arginine to asthma.
Topics: Airway Remodeling; Animals; Arginine; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cell Count; Chronic Disease; Disease Models, Animal; Epithelial Cells; Epithelium; Lung; Male; Mice; Mice, Inbred BALB C; Mucus; Nitric Oxide; Nitric Oxide Synthase Type III; Nitrosation; Pneumonia; Simvastatin; Stress, Physiological | 2011 |
C-terminus of heat shock protein 70-interacting protein-dependent GTP cyclohydrolase I degradation in lambs with increased pulmonary blood flow.
Topics: Animals; Anthracenes; Arginine; Blood Flow Velocity; Disease Models, Animal; Female; GTP Cyclohydrolase; Heart Defects, Congenital; HSP70 Heat-Shock Proteins; HSP90 Heat-Shock Proteins; Lung; Nitric Oxide; Nitric Oxide Synthase; Propane; Proteasome Endopeptidase Complex; Sheep | 2011 |
Asymmetric dimethylarginine potentiates lung inflammation in a mouse model of allergic asthma.
Topics: Amidohydrolases; Animals; Arginine; Asthma; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Enzyme Inhibitors; Epithelial Cells; Humans; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Transgenic; Nitric Oxide Synthase Type II; Nitrites; Ovalbumin; Pneumonia; Respiratory Mucosa | 2010 |
The impact of rapid atrial pacing on ADMA and endothelial NOS.
Topics: Aged; Animals; Arginine; Atrial Fibrillation; Calcium-Binding Proteins; Disease Models, Animal; Endothelium, Vascular; Female; Heart Rate; Human Umbilical Vein Endothelial Cells; Humans; Male; Middle Aged; Myocardial Contraction; Nitric Oxide Synthase Type III; Oxidative Stress; Pacemaker, Artificial; Risk Factors; Swine; Tachycardia; Ventricular Function, Left | 2012 |
Ramipril retards development of aortic valve stenosis in a rabbit model: mechanistic considerations.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Aortic Valve; Aortic Valve Stenosis; Arginine; Carrier Proteins; Disease Models, Animal; Disease Progression; Echocardiography; Enzyme Inhibitors; Ergocalciferols; Humans; Male; Rabbits; Ramipril; Vitamins | 2011 |
Time course of asymmetric dimethylarginine (ADMA) and oxidative stress in fructose-hypertensive rats: a model related to metabolic syndrome.
Topics: Animals; Aorta; Arginine; Blood Glucose; Blood Pressure; Body Weight; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fructose; Heart Rate; Hypertension; Male; Metabolic Syndrome; NADPH Oxidases; Nitric Oxide Synthase Type II; Oxidative Stress; Rats; Rats, Sprague-Dawley; Time Factors; Tyrosine; Vasodilation; Vasodilator Agents | 2011 |
The levels of nitric oxide and asymmetric dimethylarginine in the rat endometriosis model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arginine; Disease Models, Animal; Endometriosis; Female; Nitric Oxide; Peritoneal Diseases; Random Allocation; Rats; Rats, Sprague-Dawley | 2011 |
Left ventricular hypertrophy is associated with inflammation in sodium loaded subtotal nephrectomized rats.
Topics: Animals; Arginine; Creatinine; Disease Models, Animal; Fibrosis; Hypertension; Hypertrophy, Left Ventricular; Inflammation; Interleukin-6; Kidney Failure, Chronic; Male; Nephrectomy; Parathyroid Hormone; Phosphates; Rats; Rats, Wistar; Risk Factors; Sclerosis; Sodium Chloride | 2011 |
Chronic renal failure alters endothelial function in cerebral circulation in mice.
Topics: Analysis of Variance; Animals; Apolipoproteins E; Arginine; Arterioles; Blotting, Western; Caveolin 1; Cerebrovascular Circulation; Cerebrovascular Disorders; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelium, Vascular; Female; Inflammation Mediators; Kidney Failure, Chronic; Mice; Mice, Inbred C57BL; Mice, Knockout; Nephrectomy; Nitric Oxide; Nitric Oxide Synthase Type III; Phosphorylation; Pia Mater; PPAR gamma; rho-Associated Kinases; Vascular Cell Adhesion Molecule-1; Vasodilation; Vasodilator Agents | 2011 |
Effect of silibinin on endothelial dysfunction and ADMA levels in obese diabetic mice.
Topics: Acetylcholine; Animals; Antioxidants; Aorta; Arginine; Diabetes Mellitus; Disease Models, Animal; Endothelium, Vascular; Insulin Resistance; Liver; Male; Mice; Mice, Obese; Nitroprusside; Obesity; Phenylephrine; Silybin; Silymarin; Vasoconstrictor Agents; Vasodilator Agents | 2011 |
A dietary approach to increase in-stent stenosis and face validity of a rat model for arterial angioplasty and stenting.
Topics: Angioplasty, Balloon; Animals; Arginine; Biomarkers; Carotid Arteries; Carotid Artery Injuries; Carotid Stenosis; Choline Deficiency; Diet, Atherogenic; Disease Models, Animal; Endothelial Cells; Female; Hyperplasia; Inflammation Mediators; Interleukin-6; Lipids; Male; Platelet Activation; Rats; Rats, Sprague-Dawley; Recurrence; Reproducibility of Results; Stents; Thromboxane B2; Time Factors; Ultrasonography, Doppler, Color | 2011 |
Inhibition of eNOS phosphorylation mediates endothelial dysfunction in renal failure: new effect of asymmetric dimethylarginine.
Topics: Amidohydrolases; Animals; Arginine; Disease Models, Animal; Endothelium, Vascular; Human Umbilical Vein Endothelial Cells; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nitric Oxide Synthase Type III; Phosphorylation; Recombinant Proteins; Renal Insufficiency, Chronic; Vasodilation | 2012 |
Nitric oxide and L-arginine metabolism in a devascularized porcine model of acute liver failure.
Topics: Animals; Arginase; Arginine; Citrulline; Disease Models, Animal; Female; Liver; Liver Failure, Acute; Nitric Oxide; Ornithine; Portacaval Shunt, Surgical; Sus scrofa | 2012 |
Nitric oxide synthase, ADMA, SDMA, and nitric oxide activity in the paraventricular nucleus throughout the etiology of renal wrap hypertension.
Topics: Animals; Arginine; Blood Pressure; Disease Models, Animal; Enzyme Inhibitors; Hypertension, Renal; Kidney; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Paraventricular Hypothalamic Nucleus; Rats; Rats, Sprague-Dawley | 2012 |
Preserving mitochondrial function prevents the proteasomal degradation of GTP cyclohydrolase I.
Topics: Acetylcarnitine; Adaptor Proteins, Signal Transducing; Animals; Animals, Newborn; Arginine; Biopterins; Disease Models, Animal; Endothelial Cells; Female; GTP Cyclohydrolase; HSP70 Heat-Shock Proteins; Hypertension, Pulmonary; Mitochondria; Nitric Oxide; Nitric Oxide Synthase; Pregnancy; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pulmonary Artery; Pulmonary Heart Disease; Sheep; Signal Transduction; Ubiquitin-Protein Ligases; Ubiquitination | 2012 |
Proteinuria elevates asymmetric dimethylarginine levels via protein arginine methyltransferase-1 overexpression in a rat model of nephrotic syndrome.
Topics: Acetylcysteine; Animals; Antioxidants; Arginine; Cells, Cultured; Disease Models, Animal; Doxorubicin; Epithelial Cells; Gene Expression Regulation, Enzymologic; Humans; Kidney Tubules, Proximal; Male; Nephrotic Syndrome; Oxidative Stress; Protein-Arginine N-Methyltransferases; Proteinuria; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Serum Albumin; Time Factors | 2012 |
Assessment of the endothelial functions in monocrotaline-induced pulmonary hypertension.
Topics: Animals; Aorta, Thoracic; Arginine; Disease Models, Animal; Endothelium, Vascular; Hydrogen Sulfide; Hypertension, Pulmonary; Iloprost; Male; Monocrotaline; Nitric Oxide; Piperazines; Pulmonary Artery; Purines; Rats; Rats, Sprague-Dawley; Sildenafil Citrate; Sulfones; Vasodilation; Vasodilator Agents | 2013 |
Disruption of endothelial cell mitochondrial bioenergetics in lambs with increased pulmonary blood flow.
Topics: Adenosine Triphosphate; Animals; Arginine; Carnitine; Disease Models, Animal; Endothelial Cells; Heart Defects, Congenital; Homeostasis; Hypertension, Pulmonary; Lung; Mitochondria; Nitric Oxide; Nitric Oxide Synthase Type III; Pulmonary Circulation; Regional Blood Flow; Sheep; Signal Transduction | 2013 |
Melatonin regulates L-arginine transport and NADPH oxidase in young rats with bile duct ligation: role of protein kinase C.
Topics: Animals; Arginase; Arginine; Biological Transport; Cationic Amino Acid Transporter 1; Cholestasis, Extrahepatic; Common Bile Duct; Disease Models, Animal; Female; Injections, Intraperitoneal; Kidney; Ligation; Liver; Male; Melatonin; NADPH Oxidases; Protein Kinase C; Protein Kinase C beta; Protein Kinase C-alpha; Protein Kinase Inhibitors; Protein Transport; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species | 2013 |
Evidence for dysregulation of dimethylarginine dimethylaminohydrolase I in chronic hypoxia-induced pulmonary hypertension.
Topics: Amidohydrolases; Animals; Arginine; Blotting, Western; Chronic Disease; Disease Models, Animal; Enzyme Activation; Hypertension, Pulmonary; Hypoxia; Isoenzymes; Lung; Male; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitrites; Rats; Rats, Sprague-Dawley | 2003 |
17beta-estradiol preserves endothelial function by reduction of the endogenous nitric oxide synthase inhibitor level.
Topics: Analysis of Variance; Animals; Aorta, Thoracic; Arginine; Cholesterol, LDL; Disease Models, Animal; Endothelium, Vascular; Enzyme-Linked Immunosorbent Assay; Estradiol; Male; Malondialdehyde; Nitric Oxide Synthase; Probability; Random Allocation; Rats; Rats, Sprague-Dawley; Sensitivity and Specificity | 2004 |
Association between cerebrospinal fluid levels of asymmetric dimethyl-L-arginine, an endogenous inhibitor of endothelial nitric oxide synthase, and cerebral vasospasm in a primate model of subarachnoid hemorrhage.
Topics: Animals; Arginine; Disease Models, Animal; Enzyme Inhibitors; Macaca fascicularis; Middle Cerebral Artery; Nitric Oxide; Nitric Oxide Synthase; Subarachnoid Hemorrhage; Time Factors; Vasospasm, Intracranial | 2004 |
Increased levels and reduced catabolism of asymmetric and symmetric dimethylarginines in pulmonary hypertension.
Topics: Amidohydrolases; Animals; Arginine; Disease Models, Animal; Humans; Hypertension, Pulmonary; Isoenzymes; Lung; Male; Monocrotaline; Nitric Oxide; Rats; Rats, Sprague-Dawley | 2005 |
ADMA regulates angiogenesis: genetic and metabolic evidence.
Topics: Animals; Arginine; Blotting, Western; Disease Models, Animal; Female; Hypercholesterolemia; Ischemia; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neovascularization, Physiologic; Nitric Oxide Synthase | 2005 |
Dimethylarginine dimethylaminohydrolase promotes endothelial repair after vascular injury.
Topics: Amidohydrolases; Animals; Arginine; Cell Proliferation; Disease Models, Animal; Endothelium, Vascular; Enzyme Induction; Femoral Artery; Humans; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neovascularization, Physiologic; Nitric Oxide; Probability; Random Allocation; Sensitivity and Specificity; Species Specificity; Vascular Diseases | 2007 |
Dimethylarginine dimethylaminohydrolase prevents progression of renal dysfunction by inhibiting loss of peritubular capillaries and tubulointerstitial fibrosis in a rat model of chronic kidney disease.
Topics: Amidohydrolases; Animals; Arginine; Capillaries; Chronic Disease; Disease Models, Animal; Disease Progression; Fibrosis; Gene Expression Regulation, Enzymologic; Genetic Therapy; Kidney; Kidney Diseases; Male; Rats; Rats, Sprague-Dawley; Transforming Growth Factor beta | 2007 |
Role of nitric oxide deficiency in the development of hypertension in hydronephrotic animals.
Topics: Animals; Arginine; Blood Pressure; Disease Models, Animal; Diuresis; Enzyme Inhibitors; Hydronephrosis; Hypertension; Indazoles; Kidney; Kidney Cortex; Kidney Tubules, Proximal; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type III; Potassium; Rats; Rats, Sprague-Dawley; Sodium; Sodium Chloride, Dietary; Ureteral Obstruction | 2008 |
The homocysteine paradox.
Topics: Animals; Arginine; Cardiovascular Diseases; Cystatin C; Cystatins; Disease Models, Animal; Folic Acid; Glomerular Filtration Rate; Homocysteine; Humans; Hyperhomocysteinemia; Kidney Diseases; Risk Factors; Vitamin B 12; Vitamin B 6 | 2008 |
High NaCl intake decreases both flow-induced dilation and pressure-induced myogenic tone in resistance arteries from normotensive rats: involvement of cyclooxygenase-2.
Topics: Animals; Arginine; Blood Pressure; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Disease Models, Animal; Endothelium, Vascular; Indomethacin; Isoenzymes; Mesenteric Arteries; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred WKY; Regional Blood Flow; Sodium Chloride, Dietary; Sulfonamides; Vasodilation | 2001 |
Accumulated endogenous NOS inhibitors, decreased NOS activity, and impaired cavernosal relaxation with ischemia.
Topics: Animals; Arginine; Calcium; Carbachol; Cholinergic Agonists; Cyclic GMP; Disease Models, Animal; Dose-Response Relationship, Drug; Electric Stimulation; Endothelium, Vascular; Enzyme Inhibitors; Iliac Artery; Impotence, Vasculogenic; In Vitro Techniques; Ischemia; Male; Nitric Oxide Synthase; omega-N-Methylarginine; Penis; Rabbits; Vasoconstrictor Agents; Vasodilator Agents | 2002 |