n,n-dimethylarginine has been researched along with Alloxan Diabetes in 25 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (4.00) | 18.2507 |
| 2000's | 7 (28.00) | 29.6817 |
| 2010's | 13 (52.00) | 24.3611 |
| 2020's | 4 (16.00) | 2.80 |
| Authors | Studies |
|---|---|
| Huang, CY; Jiang, JL; Li, G; Li, MY; Wu, MT; Xiong, XM; Zhou, T | 1 |
| Bode-Böger, SM; Brilloff, S; Hohenstein, B; Hugo, C; Jarzebska, N; Martens-Lobenhoffer, J; Rexin, A; Rodionov, RN; Schneider, A; Sradnick, J; Todorov, V; Weiss, N | 1 |
| Abdel-Rahman, AA; Leffler, KE | 1 |
| Awad, AS; Cooper, TK; Gao, T; Morris, SM; Stanley, K; Wetzel, MD | 1 |
| Abdel-Latif, Y; Badawy, E; El-Laithy, N; El-Naggar, M; El-Waseef, M; Hassan, H; Hussein, J | 1 |
| He, YL; Li, XM; Nie, F; Xiong, Y; Zhou, XK | 1 |
| Cao, J; Lei, T; Liu, S; Lu, Z; Shi, L; Wang, H; Zhao, C | 1 |
| Bode-Böger, SM; Brilloff, S; Heinrich, A; Hohenstein, B; Hugo, CPM; Jarzebska, N; Martens-Lobenhoffer, J; Rodionov, RN; Todorov, VT; Weiss, N | 1 |
| Du, MR; Jiang, JL; Li, NS; Wang, YJ; Yan, L; Zhou, T | 1 |
| Fu, Q; Hu, LL; Tian, T; Zhang, H; Zhang, KQ | 1 |
| Ali, O; El-Naggar, M; El-Toukhy, S; Harvy, M; Hussein, JS; Nabeeh, M; Raafat, J; Ramzy, T; Rasheed, W | 1 |
| Behrmann, A; Bello Arredondo, Y; Brill, LM; Cheng, SL; Kapoor, K; Kovacs, A; Krchma, K; Mead, M; Perera, R; Ramachandran, B; Shao, JS; Smith, C; Towler, DA; Williams, BO | 1 |
| Chen, Y; Gu, Q; Sheng, M; Xu, X; Zhang, X; Zheng, Z | 1 |
| Feng, M; Guo, Z; He, ZM; Lu, CW; Wu, ZZ; Xiong, Y | 1 |
| Brasacchio, D; Chin-Dusting, J; Cooper, ME; Coughlan, MT; Forbes, JM; Harris, E; Kaye, D; Paavonen, K; Soro-Paavonen, A; Thomas, MC; Tong, DC; Venardos, K; Zhang, WZ | 1 |
| Chen, MS; Chen, N; Leng, YP; Luo, JD; Xiong, Y; Xu, WJ | 1 |
| Arend, A; Aunapuu, M; Avolio, AP; Butlin, M; Eha, J; Kals, J; Kampus, P; Põdramägi, T; Salum, E; Zilmer, M | 1 |
| Fukami, K; Ishibashi, Y; Maeda, S; Matsui, T; Nishino, Y; Ojima, A; Takeuchi, M; Yamagishi, S | 1 |
| Adimoolam, S; Asagami, T; Cooke, JP; Ito, A; Kimoto, M; Lin, KY; Reaven, GM; Tsao, PS; Tsuji, H | 1 |
| Fu, SH; Fu, YF; Xiong, Y; Zhou, HH | 1 |
| Fu, S; Fu, Y; Lei, M; Xiong, Y | 1 |
| Buerk, DG; Carlsson, PO; Hansell, P; Liss, P; Palm, F | 1 |
| Deng, HW; Deng, S; Jia, SJ; Li, D; Li, YJ; Wang, L; Xia, K; Yang, ZC; Zhang, XH; Zhang, Z | 1 |
| Beckmann, B; Chobanyan, K; Gutzki, FM; Mitschke, A; Stichtenoth, DO; Suchy, MT; Thum, T; Tsikas, D; Zhu, B | 1 |
| Deng, HW; Li, YJ; Lu, R; Xiong, Y | 1 |
25 other study(ies) available for n,n-dimethylarginine and Alloxan Diabetes
| Article | Year |
|---|---|
Asymmetric dimethylarginine aggravates blood-retinal barrier breakdown of diabetic retinopathy via inhibition of intercellular communication in retinal pericytes.
Topics: Animals; Apoptosis; Arginine; Blood-Retinal Barrier; Cell Communication; Cell Membrane Permeability; Cells, Cultured; Connexin 43; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Gap Junctions; Glucose; Male; Pericytes; Rats; Rats, Sprague-Dawley; Streptozocin | 2019 |
ADMA elevation does not exacerbate development of diabetic nephropathy in mice with streptozotocin-induced diabetes mellitus.
Topics: Amidohydrolases; Animals; Arginine; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Glomerular Filtration Rate; Male; Mice; Mice, Inbred C57BL; Risk Factors; Streptozocin | 2019 |
Restoration of Adiponectin-Connexin43 Signaling Mitigates Myocardial Inflammation and Dysfunction in Diabetic Female Rats.
Topics: Adiponectin; Animals; Arginine; Connexin 43; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diabetic Cardiomyopathies; Estradiol; Estrogen Receptor alpha; Female; Heme Oxygenase (Decyclizing); Hypertrophy, Left Ventricular; Ovariectomy; Piperidines; Rats, Wistar; Receptors, Adiponectin; Receptors, G-Protein-Coupled; Signal Transduction; Tumor Necrosis Factor-alpha; Ventricular Dysfunction, Left; Ventricular Function, Left; Ventricular Remodeling | 2020 |
Enhancing kidney DDAH-1 expression by adenovirus delivery reduces ADMA and ameliorates diabetic nephropathy.
Topics: Adenoviridae; Albuminuria; Amidohydrolases; Animals; Arginine; Cytokines; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Fibrosis; Genetic Therapy; Genetic Vectors; Inflammation Mediators; Kidney; Male; Mice, Inbred DBA; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Signal Transduction; Thiobarbituric Acid Reactive Substances | 2020 |
Homocysteine and Asymmetrical Dimethylarginine in Diabetic Rats Treated with Docosahexaenoic Acid-Loaded Zinc Oxide Nanoparticles.
Topics: Animals; Arginine; Cellulose; Diabetes Mellitus, Experimental; Docosahexaenoic Acids; Homocysteine; Hyperhomocysteinemia; Insulin; Insulin Resistance; Male; Metal Nanoparticles; Microscopy, Electron, Transmission; Nitric Oxide; Rats; Risk Factors; Zinc Oxide | 2020 |
Endogenous asymmetric dimethylarginine accumulation precipitates the cardiac and mitochondrial dysfunctions in type 1 diabetic rats.
Topics: Acetylcysteine; Animals; Arginine; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Free Radical Scavengers; Glycosylation; Heart Diseases; Insulin Resistance; Male; Mitochondria; Myocardial Contraction; Myocytes, Cardiac; Nitric Oxide; Papillary Muscles; Rats, Sprague-Dawley; Signal Transduction; Streptozocin | 2021 |
Dimethylarginine Dimethylaminohydrolase 1 Deficiency Induces the Epithelial to Mesenchymal Transition in Renal Proximal Tubular Epithelial Cells and Exacerbates Kidney Damage in Aged and Diabetic Mice.
Topics: Aging; Aldosterone; Amidohydrolases; Animals; Arginine; Cell Line; Creatinine; Diabetes Mellitus, Experimental; Disease Models, Animal; Epithelial Cells; Epithelial-Mesenchymal Transition; Fibrosis; Gene Knockout Techniques; Humans; Kidney Diseases; Kidney Tubules, Proximal; Mice | 2017 |
ADMA reduction does not protect mice with streptozotocin-induced diabetes mellitus from development of diabetic nephropathy.
Topics: Albuminuria; Amidohydrolases; Animals; Arginine; Cell Proliferation; Creatinine; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Disease Progression; Down-Regulation; Genetic Predisposition to Disease; Glomerular Mesangium; Glomerulonephritis; Hydrolysis; Kidney; Male; Mice, Inbred C57BL; Mice, Transgenic; Phenotype; Streptozocin | 2017 |
Asymmetric dimethylarginine contributes to retinal neovascularization of diabetic retinopathy through EphrinB2 pathway.
Topics: Amidohydrolases; Animals; Arginine; Cell Hypoxia; Cell Line; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Endothelial Cells; Ephrin-B2; Human Umbilical Vein Endothelial Cells; Humans; Macaca mulatta; Male; Protein-Arginine N-Methyltransferases; Rats, Sprague-Dawley; Retinal Neovascularization; Retinal Vessels; RNA Interference; Signal Transduction | 2018 |
Probucol improves erectile function via Activation of Nrf2 and coordinates the HO-1 / DDAH / PPAR-γ/ eNOS pathways in streptozotocin-induced diabetic rats.
Topics: Amidohydrolases; Animals; Arginine; Blood Glucose; Body Weight; Cyclic GMP; Diabetes Mellitus, Experimental; Erectile Dysfunction; Heme Oxygenase-1; Male; Malondialdehyde; NF-E2-Related Factor 2; Nitric Oxide Synthase Type III; PPAR gamma; Probucol; Rats, Sprague-Dawley; Signal Transduction; Streptozocin; Superoxide Dismutase | 2018 |
Synthesis of docosahexaenoic acid-loaded silver nanoparticles for improving endothelial dysfunctions in experimental diabetes.
Topics: Animals; Arginine; Aryldialkylphosphatase; Blood Glucose; Diabetes Mellitus, Experimental; DNA Damage; Docosahexaenoic Acids; Insulin; Male; Membrane Lipids; Metal Nanoparticles; Nitric Oxide; Rats, Wistar; Silver | 2019 |
Vascular smooth muscle LRP6 limits arteriosclerotic calcification in diabetic LDLR-/- mice by restraining noncanonical Wnt signals.
Topics: Animals; Arginine; Arteriosclerosis; Calcinosis; Diabetes Mellitus, Experimental; Dietary Fats; Frizzled Receptors; Gene Expression Regulation; Histones; Low Density Lipoprotein Receptor-Related Protein-6; Male; Mice; Mice, Knockout; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Osteopontin; Paracrine Communication; Protein Interaction Mapping; Protein-Arginine N-Methyltransferases; Receptors, Cell Surface; Receptors, LDL; Upstream Stimulatory Factors; Vascular Stiffness; Wnt Signaling Pathway | 2015 |
PRMT-1 and DDAHs-induced ADMA upregulation is involved in ROS- and RAS-mediated diabetic retinopathy.
Topics: Amidohydrolases; Animals; Arginine; Blotting, Western; Cells, Cultured; Cyclic GMP; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Endothelial Cells; Male; Protein-Arginine N-Methyltransferases; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Renin-Angiotensin System; Up-Regulation | 2009 |
Ex vivo gene transferring of human dimethylarginine dimethylaminohydrolase-2 improved endothelial dysfunction in diabetic rat aortas and high glucose-treated endothelial cells.
Topics: Amidohydrolases; Animals; Aorta; Arginine; Diabetes Mellitus; Diabetes Mellitus, Experimental; Endothelium, Vascular; Gene Transfer Techniques; Glucose; Humans; Hyperglycemia; Male; Rats; Rats, Sprague-Dawley | 2010 |
Advanced glycation end-products induce vascular dysfunction via resistance to nitric oxide and suppression of endothelial nitric oxide synthase.
Topics: Animals; Aorta, Thoracic; Arginine; Cattle; Cells, Cultured; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Endothelial Cells; Glycation End Products, Advanced; Hypoglycemic Agents; Male; Nitric Oxide; Nitric Oxide Synthase Type III; Rats; Rats, Sprague-Dawley; Vascular Diseases; Vasodilation; Vasodilator Agents | 2010 |
Contribution of endogenous inhibitor of nitric oxide synthase to hepatic mitochondrial dysfunction in streptozotocin-induced diabetic rats.
Topics: Adenosine Triphosphate; Animals; Arginine; Cell Line, Tumor; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Hepatocytes; Ion Channels; Liver; Male; Malondialdehyde; Membrane Potential, Mitochondrial; Mitochondria, Liver; Mitochondrial Proteins; Nitric Oxide; Nitric Oxide Synthase; Oxidative Stress; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Rats; Rats, Sprague-Dawley; RNA-Binding Proteins; Superoxide Dismutase; Transcription Factors; Uncoupling Protein 2 | 2011 |
Effect of vitamin D on aortic remodeling in streptozotocin-induced diabetes.
Topics: Animals; Aorta, Thoracic; Aortic Diseases; Arginine; Biomarkers; Blood Pressure; Cholecalciferol; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Dietary Supplements; Elastic Tissue; Elasticity; Endothelium, Vascular; Enzyme-Linked Immunosorbent Assay; Male; Pulsatile Flow; Radioimmunoassay; Rats; Rats, Wistar; Streptozocin; Time Factors; Vasoconstrictor Agents; Vasodilator Agents; Vitamin D | 2012 |
Glucagon-like peptide-1 receptor agonist inhibits asymmetric dimethylarginine generation in the kidney of streptozotocin-induced diabetic rats by blocking advanced glycation end product-induced protein arginine methyltranferase-1 expression.
Topics: Animals; Arginine; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Drug Evaluation, Preclinical; Exenatide; Gene Expression Regulation, Enzymologic; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glycation End Products, Advanced; Humans; Hypertrophy; Hypoglycemic Agents; Kidney; Kidney Glomerulus; Kidney Tubules; Macrophages; Male; Peptides; Protein-Arginine N-Methyltransferases; Rats; Rats, Wistar; Reactive Oxygen Species; Receptor for Advanced Glycation End Products; Receptors, Glucagon; Receptors, Immunologic; Repressor Proteins; RNA, Messenger; Venoms | 2013 |
Impaired nitric oxide synthase pathway in diabetes mellitus: role of asymmetric dimethylarginine and dimethylarginine dimethylaminohydrolase.
Topics: Amidohydrolases; Animals; Antioxidants; Aorta; Arginine; Cell Line; Cells, Cultured; Cyclic GMP; Diabetes Mellitus, Experimental; Endothelium, Vascular; Enzyme Inhibitors; Glucose; Humans; Male; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Oxidative Stress; Polyethylene Glycols; Rats; Rats, Sprague-Dawley; Superoxide Dismutase | 2002 |
Elevated levels of the serum endogenous inhibitor of nitric oxide synthase and metabolic control in rats with streptozotocin-induced diabetes.
Topics: Animals; Arginine; Blood Glucose; Chromatography, High Pressure Liquid; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Insulin; Male; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley | 2003 |
Effect of diabetic duration on serum concentrations of endogenous inhibitor of nitric oxide synthase in patients and rats with diabetes.
Topics: Adult; Aged; Animals; Arginine; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Female; Humans; Male; Middle Aged; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Streptozocin; Time Factors; Vasoconstriction | 2005 |
Reduced nitric oxide concentration in the renal cortex of streptozotocin-induced diabetic rats: effects on renal oxygenation and microcirculation.
Topics: Animals; Arginine; Diabetes Mellitus, Experimental; Kidney Cortex; Male; Microcirculation; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxidative Stress; Oxygen; Rats; Rats, Inbred WF; Renal Circulation | 2005 |
Asymmetric dimethylarginine reduced erythrocyte deformability in streptozotocin-induced diabetic rats.
Topics: Animals; Aorta, Thoracic; Arginine; Diabetes Mellitus, Experimental; Endothelium, Vascular; Erythrocyte Deformability; In Vitro Techniques; Male; Malondialdehyde; Nitric Oxide; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Vitamin E | 2007 |
GC-MS assay for hepatic DDAH activity in diabetic and non-diabetic rats by measuring dimethylamine (DMA) formed from asymmetric dimethylarginine (ADMA): evaluation of the importance of S-nitrosothiols as inhibitors of DDAH activity in vitro and in vivo in
Topics: Amidohydrolases; Animals; Arginine; Catalysis; Diabetes Mellitus, Experimental; Dimethylamines; Enzyme Inhibitors; Female; Gas Chromatography-Mass Spectrometry; Humans; Kinetics; Liver; Male; Molecular Structure; Nitrates; Nitrites; Rats; Rats, Wistar; Reproducibility of Results; S-Nitrosothiols | 2007 |
Elevation of an endogenous inhibitor of nitric oxide synthase in diabetic rat serum.
Topics: Animals; Aorta; Arginine; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Male; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Rats; Rats, Sprague-Dawley; Vasodilation | 1997 |