Page last updated: 2024-09-03

n,n-dimethylarginine and Aging

n,n-dimethylarginine has been researched along with Aging in 32 studies

Research

Studies (32)

TimeframeStudies, this research(%)All Research%
pre-19901 (3.13)18.7374
1990's1 (3.13)18.2507
2000's14 (43.75)29.6817
2010's16 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Cao, J; Lei, T; Liu, S; Lu, Z; Shi, L; Wang, H; Zhao, C1
Antal, M; Contreras, GA; Dormann, D; Fekecs, Z; Guo, X; Hickman, J; Hortobagyi, T; Horvath, A; Jiang, LL; Karolyi, K; Keresztessy, Z; Kiss, G; Kolostyak, Z; Nagy, L; Nógrádi, A; Pajer, K; Pap, A; Papp, Z; Patsalos, A; Reho, B; Sari, Z; Sieler, T; Simandi, Z; Vámosi, G; Xu, H1
Endo, H; Kajitani, S; Kanazawa, M; Kondo, M; Nakamura, A; Nozaki, E; Sato, K1
Carru, C; Mangoni, AA; McEvoy, M; Rodionov, RN; Sotgia, S; Zinellu, A1
Baamonde-Laborda, E; Gonzalez-Cabrera, F; Oliva-Damaso, E; Oliva-Damaso, N; Payan, J; Rodriguez-Esparragon, F; Rodriguez-Perez, JC; Santana-Estupiñan, R1
Bouras, G; Chatzis, G; Cleman, MW; Deftereos, S; Giannopoulos, G; Stefanadis, C; Tousoulis, D; Tsounis, D1
Chan, WP; Chirkov, YY; Horowitz, JD; Ngo, DT; Sverdlov, AL1
Kurumatani, N; Obayashi, K; Saeki, K1
Dhondt, A; Eloot, S; Glorieux, G; Liabeuf, S; Massy, Z; Neirynck, N; Rroji, M; Van Biesen, W; Vandennoortgate, N; Vanholder, R1
Adams, V; Erbs, S; Gielen, S; Hambrecht, R; Höllriegel, R; Kirsch, K; Linke, A; Lurz, P; Mangner, N; Möbius-Winkler, S; Rabald, K; Sandri, M; Schuler, G; Teupser, D; Thiery, J; Viehmann, M1
Basili, S; Campesi, I; Carru, C; Cherchi, S; Franconi, F; Occhioni, S; Tonolo, G; Zinellu, A1
Chen, Z; Cui, K; Liu, J; Luan, Y; Rao, K; Tang, Z; Wang, D; Wang, S; Wang, T1
Abe, Y; Arai, Y; Hirata, T; Ohkuma, K; Takayama, M; Takebayashi, T1
Gongora, E; Nair, N1
Beaudeux, JL; Cottart, CH; Klimczak, C; Laguillier, C; Nivet-Antoine, V; Sebban, C1
Horowitz, JD; McNeil, JJ; Ngo, DT; Sverdlov, AL1
Bogner, M; Elmadfa, I; Fabian, E1
Attia, JR; Carru, C; Mangoni, AA; McEvoy, M; Zinellu, A1
Li, NS; Li, YJ; Lu, R; Peng, J; Zhu, HQ1
Bode-Böger, SM; Fliser, D; Frölich, JC; Haller, H; Kielstein, JT; Ritz, E1
Bode-Böger, SM; Fliser, D; Haller, H; Kielstein, JT1
Selley, ML1
Azuma, H; Kihara, K; Kurosaki, E; Masuda, H; Sakai, Y; Yamauchi, Y1
Böger, RH; Freese, R; Maas, R; Schulze, F; Schwedhelm, E; Silberhorn, E1
Adegoke, OA; Chevalier, S; Gougeon, R; Lamarche, M; Marliss, EB; Morais, JA; Wu, G1
Bode-Böger, SM; Bukowska, A; Lendeckel, U; Martens-Lobenhoffer, J; Scalera, F; Täger, M1
Boucher, ML; Gates, PE; Monahan, KD; Seals, DR; Silver, AE1
Nissim, I; Pereira, G; Segal, S; Yudkoff, M1
Alexander, K; Bode-Böger, SM; Böger, RH; Frölich, JC; Junker, W; Thiele, W1
Chen, BM; Deng, HW; Li, YJ; Xiong, Y; Yuan, LW1
Abe, T; Isobe, C; Murata, T; Sato, C; Tohgi, H1
Hu, CP; Li, YJ; Liao, EY; Lu, R; Wu, XP1

Reviews

6 review(s) available for n,n-dimethylarginine and Aging

ArticleYear
New horizons in arginine metabolism, ageing and chronic disease states.
    Age and ageing, 2019, 11-01, Volume: 48, Issue:6

    Topics: Aged; Aging; Arginine; Chronic Disease; Homoarginine; Humans

2019
Asymmetric (ADMA) and Symmetric (SDMA) Dimethylarginines in Chronic Kidney Disease: A Clinical Approach.
    International journal of molecular sciences, 2019, Jul-26, Volume: 20, Issue:15

    Topics: Aging; Animals; Arginine; Cardiovascular Diseases; Endothelium, Vascular; Humans; Metabolic Networks and Pathways; Molecular Targeted Therapy; Prognosis; Renal Dialysis; Renal Insufficiency, Chronic

2019
Asymmetric Dimethylarginine (ADMA): a promising biomarker for cardiovascular disease?
    Current topics in medicinal chemistry, 2013, Volume: 13, Issue:2

    Topics: Aging; Amidohydrolases; Arginine; Biomarkers; Cardiovascular Diseases; Cerebrovascular Disorders; Chromatography, High Pressure Liquid; Diabetes Complications; Enzyme-Linked Immunosorbent Assay; Humans; Hypertension; Mass Spectrometry; Nitric Oxide; Oxidative Stress; Reference Values; Risk Factors; Smoking

2013
Oxidative Stress and Cardiovascular Aging: Interaction Between NRF-2 and ADMA.
    Current cardiology reviews, 2017, Volume: 13, Issue:3

    Topics: Aging; Animals; Arginine; Cardiovascular Diseases; Endothelium, Vascular; Humans; NF-E2-Related Factor 2; Oxidative Stress; Signal Transduction

2017
[Biology of arterial ageing and arteriosclerosis].
    Comptes rendus biologies, 2009, Volume: 332, Issue:5

    Topics: Adult; Aged; Aging; Arginine; Arteriosclerosis; Atherosclerosis; Calcinosis; Diagnostic Techniques, Cardiovascular; Endothelium, Vascular; Extracellular Matrix; Female; Humans; Hypertension; Lipoproteins; Male; Middle Aged; Monocytes; Osteoblasts; Tunica Media; Vascular Resistance

2009
Functional changes in the ageing kidney: is there a role for asymmetric dimethylarginine?
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2003, Volume: 18, Issue:7

    Topics: Adult; Aged; Aging; Arginine; Enzyme Inhibitors; Humans; Kidney; Kidney Diseases

2003

Trials

2 trial(s) available for n,n-dimethylarginine and Aging

ArticleYear
Chronic heart failure and aging - effects of exercise training on endothelial function and mechanisms of endothelial regeneration: Results from the Leipzig Exercise Intervention in Chronic heart failure and Aging (LEICA) study.
    European journal of preventive cardiology, 2016, Volume: 23, Issue:4

    Topics: Aged; Aging; Arginine; Blood Flow Velocity; Cell Count; Chemokine CXCL12; Endothelial Progenitor Cells; Endothelium, Vascular; Exercise Therapy; Heart Failure; Humans; Intercellular Adhesion Molecule-1; Middle Aged; Prospective Studies; Radial Artery; Regeneration; Vascular Cell Adhesion Molecule-1; Vascular Endothelial Growth Factor A

2016
Increased concentrations of homocysteine and asymmetric dimethylarginine and decreased concentrations of nitric oxide in the plasma of patients with Alzheimer's disease.
    Neurobiology of aging, 2003, Volume: 24, Issue:7

    Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Arginine; Enzyme Inhibitors; Female; Homocysteine; Humans; Male; Matched-Pair Analysis; Middle Aged; Nitric Oxide; Nitric Oxide Synthase; Reference Values; Statistics as Topic

2003

Other Studies

24 other study(ies) available for n,n-dimethylarginine and Aging

ArticleYear
Dimethylarginine Dimethylaminohydrolase 1 Deficiency Induces the Epithelial to Mesenchymal Transition in Renal Proximal Tubular Epithelial Cells and Exacerbates Kidney Damage in Aged and Diabetic Mice.
    Antioxidants & redox signaling, 2017, Dec-01, Volume: 27, Issue:16

    Topics: Aging; Aldosterone; Amidohydrolases; Animals; Arginine; Cell Line; Creatinine; Diabetes Mellitus, Experimental; Disease Models, Animal; Epithelial Cells; Epithelial-Mesenchymal Transition; Fibrosis; Gene Knockout Techniques; Humans; Kidney Diseases; Kidney Tubules, Proximal; Mice

2017
Arginine Methyltransferase PRMT8 Provides Cellular Stress Tolerance in Aging Motoneurons.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018, 08-29, Volume: 38, Issue:35

    Topics: Aging; Amino Acid Sequence; Animals; Arginine; Cell Line; Cyclic AMP Response Element-Binding Protein; DNA Breaks, Double-Stranded; DNA Damage; DNA Repair; Isometric Contraction; Male; Mice; Mice, Knockout; Mice, Transgenic; Motor Neurons; Muscle Cells; Neuromuscular Junction; Protein-Arginine N-Methyltransferases; Recombinant Fusion Proteins; Reflex, Abnormal; RNA Interference; RNA, Small Interfering; Rotarod Performance Test; Spinal Cord

2018
Decline of popliteal artery flow-mediated dilation with aging and possible involvement of asymmetric dimethylarginine in healthy men.
    Journal of medical ultrasonics (2001), 2019, Volume: 46, Issue:4

    Topics: Adult; Age Factors; Aging; Arginine; Brachial Artery; Endothelium, Vascular; Female; Humans; Male; Middle Aged; Popliteal Artery; Reference Values; Sex Factors; Vasodilation

2019
Aging of the nitric oxide system: are we as old as our NO?
    Journal of the American Heart Association, 2014, Aug-18, Volume: 3, Issue:4

    Topics: Aged; Aging; Arginine; Blood Platelets; Cardiovascular Diseases; Cohort Studies; Female; Follow-Up Studies; Humans; Male; Middle Aged; Nitric Oxide; Platelet Aggregation; Prospective Studies

2014
Asymmetric dimethylarginine attenuates the association of melatonin secretion with night-time blood pressure and dipping in elderly individuals.
    Circulation journal : official journal of the Japanese Circulation Society, 2014, Volume: 78, Issue:12

    Topics: Aged; Aged, 80 and over; Aging; Arginine; Blood Pressure; Body Mass Index; Circadian Rhythm; Cross-Sectional Studies; Diabetes Mellitus; Endothelium, Vascular; Female; Humans; Hypertension; Male; Melatonin; Nitric Oxide; Nitric Oxide Synthase Type III; Secretory Rate; Smoking

2014
Association of advanced age with concentrations of uraemic toxins in CKD.
    Journal of nephrology, 2016, Volume: 29, Issue:1

    Topics: Adult; Age Factors; Aged; Aged, 80 and over; Aging; Arginine; beta 2-Microglobulin; Biomarkers; Blood Urea Nitrogen; Creatinine; Female; Furans; Humans; Male; Middle Aged; Multivariate Analysis; Propionates; Renal Dialysis; Renal Insufficiency, Chronic; Uremia

2016
Ageing/Menopausal Status in Healthy Women and Ageing in Healthy Men Differently Affect Cardiometabolic Parameters.
    International journal of medical sciences, 2016, Volume: 13, Issue:2

    Topics: Adult; Aging; Arginine; Blood; Body Weight; Female; Humans; Interleukin-6; Male; Malondialdehyde; Middle Aged; Oxidative Stress; Postmenopause; Premenopause; Protein Carbonylation; Risk Factors; Triglycerides; Tumor Necrosis Factor-alpha

2016
Involvement of DDAH/ADMA/NOS/cGMP and COX-2/PTGIS/cAMP Pathways in Human Tissue Kallikrein 1 Protecting Erectile Function in Aged Rats.
    PloS one, 2017, Volume: 12, Issue:1

    Topics: Aging; Amidohydrolases; Animals; Arginine; Cyclic AMP; Cyclic GMP; Cyclooxygenase 2; Cytochrome P-450 Enzyme System; Erectile Dysfunction; Humans; Intramolecular Oxidoreductases; Male; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type III; Penile Erection; Penis; Rats; Rats, Sprague-Dawley; Rats, Transgenic; Recombinant Proteins; RNA, Messenger; Signal Transduction; Tissue Kallikreins

2017
Carotid Plaque Score and Risk of Cardiovascular Mortality in the Oldest Old: Results from the TOOTH Study.
    Journal of atherosclerosis and thrombosis, 2018, Jan-01, Volume: 25, Issue:1

    Topics: Aged; Aged, 80 and over; Aging; Arginine; Cardiovascular Diseases; Carotid Stenosis; Cohort Studies; Female; Humans; Japan; Kaplan-Meier Estimate; Male; Multivariate Analysis; Proportional Hazards Models; Risk Factors; Sensitivity and Specificity; Treatment Outcome

2018
Correlates of arterial stiffness in an ageing population: role of asymmetric dimethylarginine.
    Pharmacological research, 2009, Volume: 60, Issue:6

    Topics: Aged; Aging; Arginine; Endothelium, Vascular; Female; Humans; Hypertension; Male; Middle Aged; Risk Factors; Vascular Resistance

2009
Age-related modification of antioxidant enzyme activities in relation to cardiovascular risk factors.
    European journal of clinical investigation, 2012, Volume: 42, Issue:1

    Topics: Aged; Aged, 80 and over; Aging; Apolipoproteins A; Arginine; Cardiovascular Diseases; Catalase; Enzyme-Linked Immunosorbent Assay; Female; Fetuins; Glutathione Peroxidase; Humans; Lipid Peroxidation; Lipoproteins; Lipoproteins, LDL; Male; Oxidation-Reduction; Oxidative Stress; Risk Factors; Statistics as Topic; Superoxide Dismutase

2012
Transsulfuration pathway thiols and methylated arginines: the Hunter Community Study.
    PloS one, 2013, Volume: 8, Issue:1

    Topics: Adrenergic beta-Antagonists; Aged; Aged, 80 and over; Aging; Amidohydrolases; Arginine; Australia; C-Reactive Protein; Cardiovascular Diseases; Cohort Studies; Community Medicine; Cysteine; Dipeptides; Female; Glutathione; Homocysteine; Humans; Male; Middle Aged; Taurine

2013
Endothelium-dependent vasorelaxation and the expression of calcitonin gene-related peptide in aged rats.
    Neuropeptides, 2002, Volume: 36, Issue:6

    Topics: Aging; Animals; Arginine; Calcitonin Gene-Related Peptide; Endothelium, Vascular; Gene Expression; Male; Phenylephrine; Rats; Rats, Sprague-Dawley; RNA, Messenger; Vasoconstrictor Agents; Vasodilation

2002
Asymmetric dimethylarginine, blood pressure, and renal perfusion in elderly subjects.
    Circulation, 2003, Apr-15, Volume: 107, Issue:14

    Topics: Adult; Aged; Aging; Arginine; Blood Pressure; Female; Glomerular Filtration Rate; Hemodynamics; Humans; Hypertension; Kidney; Male; Renal Circulation; Renal Plasma Flow, Effective

2003
Involvement of increased arginase activity in impaired cavernous relaxation with aging in the rabbit.
    The Journal of urology, 2004, Volume: 172, Issue:1

    Topics: Aging; Animals; Arginase; Arginine; Carbachol; Cholinergic Agonists; Endothelium, Vascular; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nitric Oxide Synthase; omega-N-Methylarginine; Penis; Rabbits

2004
Determination of a reference value for N(G), N(G)-dimethyl-L-arginine in 500 subjects.
    European journal of clinical investigation, 2005, Volume: 35, Issue:10

    Topics: Adult; Aged; Aging; Arginine; Biomarkers; Cardiovascular Diseases; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Female; Humans; Male; Middle Aged; Nitric Oxide Synthase; Reference Values; Sensitivity and Specificity; Sex Characteristics

2005
Elevations of plasma methylarginines in obesity and ageing are related to insulin sensitivity and rates of protein turnover.
    Diabetologia, 2006, Volume: 49, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Aging; Arginine; Blood Glucose; Body Composition; Female; Glucose; Glucose Clamp Technique; Humans; Insulin; Insulin Resistance; Lipids; Male; Metabolic Syndrome; Middle Aged; Obesity; omega-N-Methylarginine; Proteins; Regression Analysis; Sex Characteristics

2006
Effect of L-arginine on asymmetric dimethylarginine (ADMA) or homocysteine-accelerated endothelial cell aging.
    Biochemical and biophysical research communications, 2006, Jul-07, Volume: 345, Issue:3

    Topics: Aging; Arginine; Cells, Cultured; Cellular Senescence; Endothelial Cells; Endothelium, Vascular; Homocysteine; Humans; NG-Nitroarginine Methyl Ester; Oxidative Stress; Telomerase; Time Factors

2006
Impaired flow-mediated dilation with age is not explained by L-arginine bioavailability or endothelial asymmetric dimethylarginine protein expression.
    Journal of applied physiology (Bethesda, Md. : 1985), 2007, Volume: 102, Issue:1

    Topics: Adolescent; Adult; Aged; Aging; Amidohydrolases; Arginine; Biological Availability; Brachial Artery; Carotid Arteries; Endothelium, Vascular; Female; Humans; Infusions, Intravenous; Male; Middle Aged; Nitric Oxide; Oxidative Stress; Regional Blood Flow; Vasodilation

2007
Urinary excretion of dimethylarginines in premature infants.
    Biochemical medicine, 1984, Volume: 32, Issue:2

    Topics: Adolescent; Adult; Aging; Arginine; Body Weight; Child; Child, Preschool; Diet; Gestational Age; Humans; Infant; Infant, Newborn; Infant, Premature; Male; Methylhistidines; Muscle Proteins; Nitrogen; Proteins

1984
Biochemical evidence for impaired nitric oxide synthesis in patients with peripheral arterial occlusive disease.
    Circulation, 1997, Apr-15, Volume: 95, Issue:8

    Topics: Adult; Aged; Aged, 80 and over; Aging; Arginine; Arterial Occlusive Diseases; Cyclic GMP; Disease Progression; Enzyme Inhibitors; Female; Humans; Male; Middle Aged; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Peripheral Vascular Diseases; Vasodilation

1997
Elevated serum endogenous inhibitor of nitric oxide synthase and endothelial dysfunction in aged rats.
    Clinical and experimental pharmacology & physiology, 2001, Volume: 28, Issue:10

    Topics: Acetylcholine; Aging; Animals; Aorta, Thoracic; Arginine; Endothelium, Vascular; Kidney; Male; Nitric Oxide Synthase; Nitrites; Rats; Rats, Sprague-Dawley; Vasodilator Agents

2001
Reduction in asymmetrical dimethylarginine, an endogenous nitric oxide synthase inhibitor, in the cerebrospinal fluid during aging and in patients with Alzheimer's disease.
    Neuroscience letters, 2001, Oct-26, Volume: 312, Issue:3

    Topics: Aged; Aging; Alzheimer Disease; Arginine; Brain; Female; Humans; Male; Middle Aged; Neurons; Nitric Oxide; Nitric Oxide Synthase; Oxidative Stress

2001
Effect of age on bone mineral density and the serum concentration of endogenous nitric oxide synthase inhibitors in rats.
    Comparative medicine, 2002, Volume: 52, Issue:3

    Topics: Absorptiometry, Photon; Aging; Animals; Arginine; Bone and Bones; Bone Density; Enzyme Inhibitors; Male; Malondialdehyde; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley

2002