n-n-dimethyl-2-(2-amino-4-cyanophenylthio)benzylamine and Neurotic-Disorders

Positron emission tomography (PET) neuroimaging provides unique possibilities to study biological processes in vivo under basal and interventional conditions. For quantification of PET data, researchers commonly apply different arrays of sequential data analytic methods ("preprocessing pipeline"), but it is often unknown how the choice of preprocessing affects the final outcome. Here, we use an available data set from a double-blind, randomized, placebo-controlled [

Topics: Adult; Artifacts; Benzylamines; Depression; Double-Blind Method; Female; Gonadal Steroid Hormones; Head Movements; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Models, Neurological; Neocortex; Neurotic Disorders; Positron-Emission Tomography; Radiopharmaceuticals; Reproducibility of Results; Serotonin Plasma Membrane Transport Proteins; Treatment Outcome; Young Adult

Personality trait is thought to be one of the important factors for vulnerability to depression. The relation between serotonin transporter (5-HTT) polymorphism and anxiety-related personality has been investigated in genetic research. In this study, we investigated the relation between in vivo regional 5-HTT binding in the brain and personality inventory measures in normal male volunteers.. Thirty-one healthy male volunteers underwent positron emission tomography scans with (11)C-labeled 3-amino-4-(2-dimethylaminomethyl-phenylsulfanyl) benzonitrile ([(11)C]DASB) to measure 5-HTT and completed revised NEO Personality Inventory. Correlation of [(11)C]DASB binding potentials (BP) with personality inventory measures was calculated using region-of-interest analysis and statistical parametric mapping based on the BP images.. Neuroticism was positively correlated with 5-HTT binding in the thalamus (p = .004). No significant correlation was observed in any other brain region. Within the neuroticism dimension, the facet of depression was positively correlated with 5-HTT binding in the thalamus (p = .001).. Subjects with higher thalamic 5-HTT binding are more likely to express higher levels of neuroticism and depressive feeling. Serotonin transporter binding in the thalamus might be a marker of vulnerability to depression.

Topics: Adult; Benzylamines; Biomarkers; Brain; Carbon Radioisotopes; Depressive Disorder; Disease Susceptibility; Humans; Male; Neurotic Disorders; Personality; Personality Inventory; Positron-Emission Tomography; Risk Factors; Serotonin Plasma Membrane Transport Proteins; Sex Factors; Thalamus