n-n-diacetylcystine and Liver-Failure--Acute

To study the therapeutic effects of N,N'-diacetyl-L-cystine (DiNAC) on immunological liver failure.. Serum ALT, AST and T cell subsets in peripheral blood of the experimental animals during the trial period were analyzed by an automatic serum analyzer and a flow cytometer, respectively. The sectioned liver specimens were examined under a light microscope. And 24 h after the injection of Gal/LPS, the survival rate of rats was calculated.. DiNAC (50, 200, 800 mg x kg(-1), i.p.) suppressed the elevation of serum levels of ALT and AST, markedly enhanced proliferation and differentiation of T cell subsets (CD4+, CD8+ and Th1, Th2), and improved all the histopathological features. In mice of fulminant hepatic failure (FHF), the survival time significantly prolonged and the survival rate increased 24 h after i.p. DiNAC. These effects were obviously dose-dependent.. DiNAC on mice with FHF has an inhibitory action which is related to immune mechanism.

Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Bilirubin; CD4 Antigens; CD8 Antigens; Cell Differentiation; Cell Proliferation; Cystine; Liver; Liver Failure, Acute; Male; Mice; Mice, Inbred BALB C; T-Lymphocytes