Compounds > n-n--((5-(2-amino-5-(2-methylpropyl)-4-thiazolyl)-2-furanyl)phosphinylidene)bis(alanine)-diethyl-ester

n-n--((5-(2-amino-5-(2-methylpropyl)-4-thiazolyl)-2-furanyl)phosphinylidene)bis(alanine)-diethyl-ester and Disease-Models--Animal

n-n--((5-(2-amino-5-(2-methylpropyl)-4-thiazolyl)-2-furanyl)phosphinylidene)bis(alanine)-diethyl-ester has been researched along with Disease-Models--Animal* in 1 studies

Other Studies

1 other study(ies) available for n-n--((5-(2-amino-5-(2-methylpropyl)-4-thiazolyl)-2-furanyl)phosphinylidene)bis(alanine)-diethyl-ester and Disease-Models--Animal

ArticleYear
Orally active aminopyridines as inhibitors of tetrameric fructose-1,6-bisphosphatase.
    Bioorganic & medicinal chemistry letters, 2011, Jun-01, Volume: 21, Issue:11

    A novel sulfonylureido pyridine series exemplified by compound 19 yielded potent inhibitors of FBPase showing significant glucose reduction and modest glycogen lowering in the acute db/db mouse model for Type-2 diabetes. Our inhibitors occupy the allosteric binding site and also extend into the dyad interface region of tetrameric FBPase.

    Topics: Administration, Oral; Allosteric Site; Aminopyridines; Animals; Crystallography, X-Ray; Diabetes Mellitus, Type 2; Disease Models, Animal; Enzyme Activation; Enzyme Inhibitors; Fructose-Bisphosphatase; Humans; Inhibitory Concentration 50; Liver; Mice; Molecular Structure

2011