n-monoacetylcystine and Hypothermia

n-monoacetylcystine has been researched along with Hypothermia* in 1 studies

Other Studies

1 other study(ies) available for n-monoacetylcystine and Hypothermia

Article	Year
Metabolism and pharmacokinetics of acetaminophen in a severely poisoned young child. The Journal of pediatrics, 1984, Volume: 105, Issue:1 A 1-year-old child with severe acetaminophen (APAP) poisoning after ingestion of 10 gm APAP demonstrated central nervous system depression, shock, hypothermia, and metabolic acidosis. There was dramatic improvement during treatment with intravenously administered N-acetylcysteine (NAC) and hemodialysis, and the patient recovered without sequelae. A detailed study of APAP metabolism was carried out during the initial 72 hours after ingestion. APAP-sulfate and APAP-glucuronide accounted for 29% and 33%, respectively, of total drug in urine, whereas cysteine and NAC conjugates accounted for only 12%. The low incidence of severe toxicity in children after overdoses of APAP may be related to greater capacity to metabolize APAP via a nontoxic pathway. Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; Cystine; Hepatomegaly; Humans; Hypothermia; Infant; Kinetics; Liver Function Tests; Male	1984

Article

Year

Metabolism and pharmacokinetics of acetaminophen in a severely poisoned young child.

The Journal of pediatrics, 1984, Volume: 105, Issue:1

A 1-year-old child with severe acetaminophen (APAP) poisoning after ingestion of 10 gm APAP demonstrated central nervous system depression, shock, hypothermia, and metabolic acidosis. There was dramatic improvement during treatment with intravenously administered N-acetylcysteine (NAC) and hemodialysis, and the patient recovered without sequelae. A detailed study of APAP metabolism was carried out during the initial 72 hours after ingestion. APAP-sulfate and APAP-glucuronide accounted for 29% and 33%, respectively, of total drug in urine, whereas cysteine and NAC conjugates accounted for only 12%. The low incidence of severe toxicity in children after overdoses of APAP may be related to greater capacity to metabolize APAP via a nontoxic pathway.

Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; Cystine; Hepatomegaly; Humans; Hypothermia; Infant; Kinetics; Liver Function Tests; Male

1984