n-methylaspartate has been researched along with Schizophrenia in 91 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 15 (16.48) | 18.2507 |
2000's | 40 (43.96) | 29.6817 |
2010's | 23 (25.27) | 24.3611 |
2020's | 13 (14.29) | 2.80 |
Authors | Studies |
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Aziz, O; Bell, JA; Bhat, S; Bloomfield, DE; Bochevarov, A; Chapman, RSL; Chauhan, A; Dahlgren, MK; Day, T; Dechaux, EA; Ellard, JM; Fraser, IJ; Frye, L; Gallati, C; Gordon, JA; Hirst, KL; Houang, E; Janssens, HB; Jensen, K; Jones, DR; Ladha, S; Lewis, JH; McRobb, FM; Osborne, JD; Palomero, MA; Sephton, M; Sharpe, A; Skene, RJ; Svensson, M; Tang, H; Tardia, P; Taylor, A; Tierney, JP; Valentine, A; Waddell, RD | 1 |
Bastos, LM; Benvenutti, R; Gallas-Lopes, M; Giongo, FK; Herrmann, AP; Rosa, AR; Sachett, A | 1 |
Bustillo, JR; Kruse, AO | 1 |
Curic, S; Haaf, M; Leicht, G; Mulert, C; Rauh, J; Steinmann, S | 1 |
Carlson, M; Choo, TH; De Baun, HM; Dias, E; Gangwisch, J; Girgis, RR; Iosifescu, DV; Kantrowitz, JT; Kegeles, LS; Mayer, MR; Medalia, A; Saperstein, AM; Sehatpour, P; Shope, C; Sobeih, T; Wall, MM | 1 |
Eo, J; Kang, J; Park, HJ; Youn, T | 1 |
Adamski, B; Biala, G; Kruk-Slomka, M; Slomka, T | 1 |
Abbasi, S; Çatal, Y; Northoff, G; Wolff, A | 1 |
Ferrarelli, F | 1 |
Jones, NC; Lee, J; Nithianantharajah, J; van den Buuse, M | 1 |
Lewis, SJ; Seckler, JM | 1 |
Chuchmacz, J; Czarnecka, K; Szymański, P; Wójtowicz, P | 1 |
Bianciardi, B; Uhlhaas, PJ | 1 |
Arbuckle, MR; Ramirez, A | 1 |
Bo-Han He, A; Chen, CC; Huang, ACW | 1 |
Elefant, F; Gao, WJ; Gulchina, Y; Snyder, MA; Xu, SJ | 1 |
Amitai, N; Powell, SB; Young, JW | 1 |
Bogart, LJ; O'Donnell, P | 1 |
Brooks, G; Hasekiu, E; Ingle Gonzalez, JE; Kusi, M; Noakes, J | 1 |
Chen, Q; Deng, W; Hu, X; Li, K; Li, L; Li, T; Lu, T; Lv, L; Ma, X; Man Wu, H; Ren, H; Sham, P; Tan, L; Tan, Q; Wang, C; Wang, L; Wang, Q; Wang, Y; Yan, H; Yang, F; Yang, G; Yang, J; Yu, H; Yue, W; Zhang, D; Zhang, F; Zhang, H; Zhang, Y; Zhao, L | 1 |
Siekmeier, PJ; vanMaanen, DP | 1 |
Bertolino, A; Blasi, G; D'Aniello, A; de Bartolomeis, A; Errico, F; Napolitano, F; Squillace, M; Usiello, A; Vitucci, D | 1 |
Bortz, DM; Bruno, JP; Jørgensen, CV; Mikkelsen, JD | 1 |
Caliph, SM; Faassen, FW; Porter, CJ | 1 |
Brindley, E; Cagney, G; Cotter, DR; Dicker, P; English, JA; Föcking, M; Lopez, LM; Wolff, A; Wynne, K | 1 |
Sivarao, DV | 1 |
Björkholm, C; Feltmann, K; Jardemark, K; Konradsson-Geuken, Å; Malmerfelt, A; Marcus, MM; Möller, A; Påhlsson, N; Schilström, B; Svensson, TH | 1 |
Gonzalez-Burgos, G; Lewis, DA | 1 |
Alonso, R; Avenet, P; Bergis, O; Biton, B; Boulay, D; Cohen, C; Coste, A; Dargazanli, G; Desvignes, C; Estenne-Bouhtou, G; George, P; Griebel, G; Lanneau, C; Oury-Donat, F; Pichat, P; Rogacki, N; Scatton, B; Sevrin, M; Steinberg, R; Stemmelin, J; Terranova, JP; Vigé, X | 1 |
Feldon, J; Yee, BK | 1 |
Bickel, S; Javitt, DC | 1 |
Hyrc, K; Thio, LL; Zhang, HX | 1 |
Alexander, KS; Brooks, JM; Bruno, JP; Sarter, M | 1 |
Bambico, FR; Gobbi, G; Labonte, B | 1 |
Autié, A; Braha, S; Januel, D; Montreuil, M; Moulier, V; Wojakiewicz, A | 1 |
Alania, M; Chikovani, M; Chkhartishvili, B; Doreulee, N; Mitaishvili, E | 1 |
Hajós, M; Hoffmann, WE; Kiss, T | 1 |
Ben Abdallah, NM; Bobsin, K; Colacicco, G; Deacon, RM; Fuss, J; Galsworthy, MJ; Gass, P; Kellendonk, C; Lipp, HP; Riva, MA; Sprengel, R; Trusel, M | 1 |
Azuma, N; Esaki, K; Furuya, S; Hamase, K; Hirabayashi, Y; Itohara, S; Kinoshita, MO; Machida, T; Messing, A; Miyoshi, Y; Sayano, T; Tomonaga, S; Wada, A; Watanabe, M; Yang, JH; Yoshida, K; Zaitsu, K | 1 |
di Prodi, P; Kolodziejski, C; McCabe, L; Porr, B; Wörgötter, F | 1 |
Deng, S; Edbauer, D; Elsworth, JD; Kenny, PJ; Kleiman, RJ; Lanz, TA; Lawrence, MS; Miller, BH; Roth, RH; Strathmann, J; Wahlestedt, C; Willoughby, D; Xi, L; Zeier, Z | 1 |
Chou, HH; Swerdlow, NR; Twamley, E | 1 |
Hwangbo, Y; Joo, J; Kim, DS; Kim, HJ; Kim, HK; Kim, JW; Kim, YO; Kwon, JT; Lee, S; Nah, SS; Shim, SH; Song, HY | 1 |
Wisniewska, MB | 1 |
Janka, Z; Pávics, L; Szekeres, G | 1 |
Avila, MT; Lahti, AC; Tamminga, CA; Thaker, GK; Weiler, MA | 1 |
Möller, HJ | 1 |
Jardemark, KE; Ninan, I; Wang, RY | 1 |
Bressan, RA; Pilowsky, LS | 1 |
Beneyto, M; Clinton, SM; McCullumsmith, RE; Meador-Woodruff, JH | 1 |
Feldon, J; Pouzet, B; Weiner, I; Yee, BK; Zhang, WN | 1 |
Abel, T; Connolly, PM; Gur, RE; Kahn, JB; Kanes, SJ; Liang, Y; Maxwell, C; Siegel, SJ; Turetsky, BI | 1 |
Bermpohl, F; Boeker, H; Grimm, S; Hell, D; Marcar, VL; Martin, E; Northoff, G; Richter, A; Wahl, C | 1 |
Abi-Dargham, A; Laruelle, M | 1 |
Hashim, A; Javitt, DC; Sershen, H | 1 |
Gourevitch, R | 1 |
Shulman, Y; Tibbo, PG | 1 |
Baldeweg, T; Friston, KJ; Stephan, KE | 1 |
Abbott, C; Bustillo, J | 1 |
Chafee, MV; MacDonald, AW | 1 |
Lewis, BL; Lipska, BK; O'Donnell, P; Tseng, KY | 1 |
Dias, EC; Javitt, DC; Rabinowicz, E; Silipo, G | 1 |
Sachdev, PS | 1 |
Belger, A; van der Stelt, O | 1 |
Williamson, P | 1 |
Heinz, A; Hinzpeter, A; Krebs, M; Leopold, K; Schaefer, M | 1 |
Cuénod, M; Do, KQ; Guidi, R; Gysin, R; Kraftsik, R; Lavoie, S; Steullet, P | 1 |
Deakin, JF; Guimarães, FS; Oliveira, RM | 1 |
Benes, FM; Coyle, JT; Grace, AA; Green, RW; Heckers, S; Javitt, DC; Lisman, JE | 1 |
Javitt, DC | 1 |
Brooks, K; Camacho, F; Corbett, R; Dunn, RW; Fishkin, RJ; Kerman, LL; Woods, AT | 1 |
Elman, I; Heresco-Levy, U; Javitt, D | 1 |
Cortinovis, S; Lucca, A; Lucini, V | 1 |
Davis, RE; Deutsch, SI; Fay-McCarthy, M; Kendrick, K; Rosse, RB | 1 |
Frank, AR; Gonzalez-Alvear, GM; Weatherspoon, JK; Werling, LL | 1 |
Wiley, JL | 1 |
Blankenstein, MA; Gispen-de Wied, C; Kahn, RS; Lipsch, C; van Berckel, BN; van Ree, JM; Wynne, HJ | 1 |
D'Souza, DC; Krystal, JH | 1 |
Feifel, D; Reza, T | 1 |
Balla, A; Javitt, DC; Lajtha, A; Sershen, H | 1 |
Breier, A | 1 |
Carlsson, A; Carlsson, ML; Waters, N | 1 |
Hashim, A; Javitt, DC; Lajtha, A; Sershen, H | 1 |
Doat, M; Rabin, RA; Winter, JC | 1 |
Bast, T; Feldon, J; Heidbreder, C; Zhang, WN | 1 |
Gaudet, I; Halim, ND; Hanlon, FM; Henning, L; Kim, YK; Swerdlow, NR | 1 |
Penn, AA | 1 |
Kornhuber, J; Weller, M | 1 |
Carlsson, A; Carlsson, M | 1 |
Kerwin, R; Meldrum, B; Patel, S | 1 |
27 review(s) available for n-methylaspartate and Schizophrenia
Article | Year |
---|---|
Glutamatergic dysfunction in Schizophrenia.
Topics: Dopamine; Glutamic Acid; Humans; Ketamine; N-Methylaspartate; Schizophrenia | 2022 |
Advances in D-Amino Acids in Neurological Research.
Topics: Alzheimer Disease; Amino Acids; Brain; Brain Chemistry; Humans; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Schizophrenia | 2020 |
Memantine in neurological disorders - schizophrenia and depression.
Topics: Alzheimer Disease; Antidepressive Agents; Antipsychotic Agents; Clinical Trials as Topic; Depression; Drug Repositioning; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Memantine; N-Methylaspartate; Neuronal Plasticity; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Serotonin 5-HT3 Receptor Antagonists | 2021 |
Do NMDA-R antagonists re-create patterns of spontaneous gamma-band activity in schizophrenia? A systematic review and perspective.
Topics: Excitatory Amino Acid Antagonists; Gamma Rhythm; Humans; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Schizophrenia | 2021 |
The 40-Hz auditory steady-state response: a selective biomarker for cortical NMDA function.
Topics: Animals; Biomarkers; Cerebral Cortex; Electroencephalography; Evoked Potentials, Auditory; Hallucinations; Humans; N-Methylaspartate; Schizophrenia; Synaptic Transmission | 2015 |
GABA neurons and the mechanisms of network oscillations: implications for understanding cortical dysfunction in schizophrenia.
Topics: Cerebral Cortex; Cyclic AMP; gamma-Aminobutyric Acid; Humans; N-Methylaspartate; Nerve Net; Neurons; Schizophrenia; Synapses | 2008 |
[Pain and schizophrenia: myth and reality].
Topics: Brain; Communication; Denial, Psychological; Emotions; Humans; Mythology; N-Methylaspartate; Pain; Pain Threshold; Reality Testing; Schizophrenia; Schizophrenic Psychology; Social Environment | 2009 |
Towards medication-enhancement of cognitive interventions in schizophrenia.
Topics: Antipsychotic Agents; Biomarkers; Cognition Disorders; Electroencephalography; Humans; N-Methylaspartate; Neuropsychological Tests; Schizophrenia; Schizophrenic Psychology | 2012 |
Physiological role of β-catenin/TCF signaling in neurons of the adult brain.
Topics: Adult; Animals; beta Catenin; Cell Differentiation; Cerebral Cortex; Glycogen Synthase Kinase 3; Hippocampus; Humans; Lymphoid Enhancer-Binding Factor 1; Mice; N-Methylaspartate; Neurodegenerative Diseases; Neurogenesis; Neuronal Plasticity; Neurons; Schizophrenia; Signal Transduction; TCF Transcription Factors; Thalamus; Wnt Proteins; Wnt Signaling Pathway | 2013 |
[Investigation of the dopamine dysregulation hypothesis of schizophrenia with neuroimaging techniques].
Topics: Amphetamine; Dopamine; Dopamine Agents; Excitatory Amino Acid Agonists; Humans; Magnetic Resonance Imaging; N-Methylaspartate; Prefrontal Cortex; Radiopharmaceuticals; Receptors, Dopamine; Schizophrenia; Tomography, Emission-Computed; Tomography, Emission-Computed, Single-Photon | 2002 |
Definition, psychopharmacological basis and clinical evaluation of novel/atypical neuroleptics: methodological issues and clinical consequences.
Topics: Acute Disease; Antipsychotic Agents; Basal Ganglia Diseases; Clinical Trials as Topic; Humans; N-Methylaspartate; Schizophrenia; Serotonin | 2000 |
[Glutamatergic hypothesis of schizophrenia].
Topics: Humans; N-Methylaspartate; Receptors, Dopamine; Receptors, N-Methyl-D-Aspartate; Schizophrenia | 2003 |
Molecular abnormalities of the glutamate synapse in the thalamus in schizophrenia.
Topics: Amino Acid Transport System X-AG; Glutamates; Humans; N-Methylaspartate; Receptors, Glutamate; Schizophrenia; Synapses; Synaptic Transmission; Thalamus | 2003 |
Mechanisms of action of second generation antipsychotic drugs in schizophrenia: insights from brain imaging studies.
Topics: Antipsychotic Agents; Brain; Dopamine; Glutamic Acid; Humans; N-Methylaspartate; Positron-Emission Tomography; Receptors, Dopamine D1; Schizophrenia; Tomography, Emission-Computed, Single-Photon | 2005 |
Neuroactive steroids in schizophrenia.
Topics: Antipsychotic Agents; Binding, Competitive; Brain Chemistry; gamma-Aminobutyric Acid; Humans; N-Methylaspartate; Receptors, Cell Surface; Schizophrenia; Steroids; Synaptic Transmission | 2005 |
Synaptic plasticity and dysconnection in schizophrenia.
Topics: Acetylcholine; Brain; Brain Mapping; Contingent Negative Variation; Dopamine; Electroencephalography; Glutamic Acid; Humans; Models, Neurological; N-Methylaspartate; Nerve Fibers; Nerve Net; Neuronal Plasticity; Schizophrenia; Synapses | 2006 |
What have we learned from proton magnetic resonance spectroscopy about schizophrenia? A critical update.
Topics: Aspartic Acid; Biomarkers; Brain; Choline; Creatine; Cross-Over Studies; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Spectroscopy; N-Methylaspartate; Neurons; Protons; Schizophrenia; Temporal Lobe | 2006 |
Translational and developmental perspective on N-methyl-D-aspartate synaptic deficits in schizophrenia.
Topics: Carrier Proteins; Cognition Disorders; Dysbindin; Dystrophin-Associated Proteins; Humans; Interdisciplinary Communication; Intracellular Signaling Peptides and Proteins; N-Methylaspartate; Nerve Net; Nerve Tissue Proteins; Neuregulin-1; Neuronal Plasticity; Prefrontal Cortex; Presynaptic Terminals; Psychological Theory; Receptors, Metabotropic Glutamate; RGS Proteins; Schizophrenia; Signal Transduction; Social Behavior | 2006 |
Alternating and postictal psychoses: review and a unifying hypothesis.
Topics: Brain; Electroencephalography; Epilepsy; gamma-Aminobutyric Acid; Humans; N-Methylaspartate; Psychotic Disorders; Schizophrenia | 2007 |
Application of electroencephalography to the study of cognitive and brain functions in schizophrenia.
Topics: Catechol O-Methyltransferase; Cognition Disorders; Electroencephalography; Event-Related Potentials, P300; gamma-Aminobutyric Acid; Gene Expression; Humans; N-Methylaspartate; Schizophrenia | 2007 |
Are anticorrelated networks in the brain relevant to schizophrenia?
Topics: Affect; Basal Ganglia; Cerebrovascular Circulation; gamma-Aminobutyric Acid; Hallucinations; Humans; N-Methylaspartate; Nerve Net; Oxygen; Schizophrenia; Signal Transduction; Thalamus | 2007 |
Circuit-based framework for understanding neurotransmitter and risk gene interactions in schizophrenia.
Topics: Animals; Cognition; Dopamine; gamma-Aminobutyric Acid; Gene Expression; Hippocampus; Homeostasis; Humans; N-Methylaspartate; Nerve Net; Neurotransmitter Agents; Receptors, N-Methyl-D-Aspartate; Risk; Schizophrenia | 2008 |
[The phencyclidine-N-methyl-D-aspartate theory of schizophrenia: clinical applications].
Topics: Humans; N-Methylaspartate; Phencyclidine; Receptors, N-Methyl-D-Aspartate; Schizophrenia | 1994 |
Behavioral pharmacology of N-methyl-D-aspartate antagonists: implications for the study and pharmacotherapy of anxiety and schizophrenia.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior; Behavior, Animal; Excitatory Amino Acid Antagonists; Humans; N-Methylaspartate; Schizophrenia; Schizophrenic Psychology | 1997 |
Cognitive deficit in schizophrenia and its neurochemical basis.
Topics: Antipsychotic Agents; Benzodiazepines; Clozapine; Cognition Disorders; Glutamic Acid; Haloperidol; Humans; N-Methylaspartate; Olanzapine; Pirenzepine; Risperidone; Schizophrenia; Schizophrenic Psychology | 1999 |
Early brain wiring: activity-dependent processes.
Topics: Axons; Brain; Cyclic AMP; gamma-Aminobutyric Acid; Geniculate Bodies; Humans; N-Methylaspartate; Nerve Growth Factors; Nerve Net; Retinal Ganglion Cells; Schizophrenia; Synapses; Visual Cortex | 2001 |
Interactions between glutamatergic and monoaminergic systems within the basal ganglia--implications for schizophrenia and Parkinson's disease.
Topics: Animals; Anticonvulsants; Aspartic Acid; Basal Ganglia; Biogenic Amines; Dibenzocycloheptenes; Dizocilpine Maleate; Glutamates; Glutamic Acid; Humans; N-Methylaspartate; Parkinson Disease; Schizophrenia | 1990 |
5 trial(s) available for n-methylaspartate and Schizophrenia
Article | Year |
---|---|
Dose-Dependent Augmentation of Neuroplasticity-Based Auditory Learning in Schizophrenia: A Double-Blind, Placebo-Controlled, Randomized, Target Engagement Clinical Trial of the NMDA Glutamate Receptor Agonist d-serine.
Topics: Antipsychotic Agents; Double-Blind Method; Excitatory Amino Acid Agonists; Glutamic Acid; Humans; N-Methylaspartate; Neuronal Plasticity; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Serine | 2023 |
Effect of Damaging Rare Mutations in Synapse-Related Gene Sets on Response to Short-term Antipsychotic Medication in Chinese Patients With Schizophrenia: A Randomized Clinical Trial.
Topics: Adult; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Antipsychotic Agents; China; Exome Sequencing; Female; Humans; Male; Mutation; N-Methylaspartate; Psychiatric Status Rating Scales; Schizophrenia; Young Adult | 2018 |
NMDA hypofunction in the posterior cingulate as a model for schizophrenia: an exploratory ketamine administration study in fMRI.
Topics: Adult; Consciousness Disorders; Double-Blind Method; Excitatory Amino Acid Antagonists; Female; Gyrus Cinguli; Humans; Ketamine; Limbic System; Magnetic Resonance Imaging; Male; Memory; N-Methylaspartate; Reaction Time; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Semantics; Surveys and Questionnaires | 2005 |
D-cycloserine adjuvant therapy to molindone in the treatment of schizophrenia.
Topics: Administration, Oral; Adult; Aged; Antipsychotic Agents; Chemotherapy, Adjuvant; Cycloserine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Humans; Middle Aged; Molindone; N-Methylaspartate; Psychiatric Status Rating Scales; Schizophrenia | 1996 |
The partial NMDA agonist D-cycloserine stimulates LH secretion in healthy volunteers.
Topics: Adult; Affect; Antipsychotic Agents; Behavior; Blood Pressure; Body Temperature; Brief Psychiatric Rating Scale; Cross-Over Studies; Cycloserine; Dopamine; Double-Blind Method; Heart Rate; Homovanillic Acid; Humans; Hydrocortisone; Luteinizing Hormone; Male; N-Methylaspartate; Neurosecretory Systems; Receptors, N-Methyl-D-Aspartate; Schizophrenia | 1998 |
59 other study(ies) available for n-methylaspartate and Schizophrenia
Article | Year |
---|---|
Discovery of a Novel Class of d-Amino Acid Oxidase Inhibitors Using the Schrödinger Computational Platform.
Topics: D-Amino-Acid Oxidase; Humans; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Serine; Structure-Activity Relationship | 2022 |
Effects of Taurine in Mice and Zebrafish Behavioral Assays With Translational Relevance to Schizophrenia.
Topics: Animals; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Mice; Mice, Inbred C57BL; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Reflex, Startle; Schizophrenia; Taurine; Zebrafish | 2023 |
Opposite Modulation of the NMDA Receptor by Glycine and S-Ketamine and the Effects on Resting State EEG Gamma Activity: New Insights into the Glutamate Hypothesis of Schizophrenia.
Topics: Biomarkers; Electroencephalography; Glutamic Acid; Humans; Ketamine; Male; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Schizophrenia | 2023 |
Neuropharmacological computational analysis of longitudinal electroencephalograms in clozapine-treated patients with schizophrenia using hierarchical dynamic causal modeling.
Topics: Brain; Brain Mapping; Clozapine; Electroencephalography; Hallucinations; Humans; Magnetic Resonance Imaging; N-Methylaspartate; Nerve Net; Neuropharmacology; Schizophrenia | 2023 |
Inhibitors of Endocannabinoids' Enzymatic Degradation as a Potential Target of the Memory Disturbances in an Acute N-Methyl-D-Aspartate (NMDA) Receptor Hypofunction Model of Schizophrenia in Mice.
Topics: Amidohydrolases; Animals; Dizocilpine Maleate; Endocannabinoids; Enzyme Inhibitors; Memory Disorders; Mice; Monoacylglycerol Lipases; N-Methylaspartate; Schizophrenia | 2023 |
Increased noise relates to abnormal excitation-inhibition balance in schizophrenia: a combined empirical and computational study.
Topics: Computer Simulation; Electroencephalography; Humans; N-Methylaspartate; Noise; Schizophrenia | 2023 |
Ketamine, NMDA hypofunction, and sleep oscillatory abnormalities in schizophrenia.
Topics: Humans; Ketamine; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Sleep | 2020 |
Acute NMDA receptor antagonism impairs working memory performance but not attention in rats-Implications for the NMDAr hypofunction theory of schizophrenia.
Topics: Animals; Antipsychotic Agents; Attention; Cognition; Cognition Disorders; Cognitive Dysfunction; Disease Models, Animal; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Male; Memory, Short-Term; N-Methylaspartate; Rats; Rats, Wistar; Reaction Time; Receptors, N-Methyl-D-Aspartate; Schizophrenia | 2020 |
The N-Methyl-D-Aspartate Receptor: Memory, Madness, and More.
Topics: Humans; Memory; N-Methylaspartate; Piperazines; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Sulfones | 2017 |
An examination of the roles of glutamate and sex in latent inhibition: Relevance to the glutamate hypothesis of schizophrenia?
Topics: Animals; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Inhibition, Psychological; Male; N-Methylaspartate; Rats; Rats, Wistar; Schizophrenia; Schizophrenic Psychology; Sex Characteristics | 2017 |
Epigenetic mechanisms underlying NMDA receptor hypofunction in the prefrontal cortex of juvenile animals in the MAM model for schizophrenia.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Cognition Disorders; Disease Models, Animal; Epigenesis, Genetic; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Female; Gene Expression Regulation, Developmental; In Vitro Techniques; Male; Methylazoxymethanol Acetate; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Prefrontal Cortex; Pregnancy; Rats; Receptors, N-Methyl-D-Aspartate; Schizophrenia | 2017 |
Phencyclidine increased while isolation rearing did not affect progressive ratio responding in rats: Investigating potential models of amotivation in schizophrenia.
Topics: Affect; Animals; Animals, Newborn; Antipsychotic Agents; Behavior, Animal; Disease Models, Animal; Excitatory Amino Acid Antagonists; Male; Motivation; N-Methylaspartate; Phencyclidine; Rats; Rats, Long-Evans; Receptors, N-Methyl-D-Aspartate; Reward; Schizophrenia; Social Isolation | 2019 |
Multiple long-range inputs evoke NMDA currents in prefrontal cortex fast-spiking interneurons.
Topics: Action Potentials; Animals; Axons; Electric Stimulation; Electrophysiological Phenomena; Interneurons; Light; Male; Mediodorsal Thalamic Nucleus; Mice; N-Methylaspartate; Patch-Clamp Techniques; Prefrontal Cortex; Pyramidal Cells; Schizophrenia | 2018 |
Modeling Schizophrenia's Abnormal Cortical Neural Synchrony in Monkeys.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Haplorhini; Humans; Ketamine; N-Methylaspartate; Schizophrenia | 2018 |
Development of antipsychotic medications with novel mechanisms of action based on computational modeling of hippocampal neuropathology.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Antipsychotic Agents; Computer Simulation; Drug Discovery; gamma-Aminobutyric Acid; Hippocampus; Humans; Models, Neurological; N-Methylaspartate; Neural Networks, Computer; Schizophrenia; User-Computer Interface | 2013 |
Decreased levels of D-aspartate and NMDA in the prefrontal cortex and striatum of patients with schizophrenia.
Topics: Adult; Aged; Aged, 80 and over; Analysis of Variance; Aspartic Acid; Chromatography, High Pressure Liquid; Corpus Striatum; Female; Humans; Male; Middle Aged; N-Methylaspartate; Postmortem Changes; Prefrontal Cortex; Receptors, N-Methyl-D-Aspartate; Schizophrenia | 2013 |
Transient inactivation of the ventral hippocampus in neonatal rats impairs the mesolimbic regulation of prefrontal glutamate release in adulthood.
Topics: Animals; Animals, Newborn; Catheters, Indwelling; Disease Models, Animal; Electrodes, Implanted; Glutamic Acid; Hippocampus; Male; Microelectrodes; N-Methylaspartate; Nucleus Accumbens; Prefrontal Cortex; Rats, Wistar; Schizophrenia; Sodium Channel Blockers; Tetrodotoxin | 2014 |
The influence of intestinal lymphatic transport on the systemic exposure and brain deposition of a novel highly lipophilic compound with structural similarity to cholesterol.
Topics: Administration, Oral; Animals; Biological Availability; Biological Transport; Brain; Central Nervous System Agents; Cholesterol; Intestinal Absorption; Intestinal Mucosa; Lipoproteins; Lymph; Lymphatic System; Male; Molecular Structure; N-Methylaspartate; Norsteroids; Rats, Sprague-Dawley; Schizophrenia | 2014 |
Proteomic and genomic evidence implicates the postsynaptic density in schizophrenia.
Topics: Animals; Antipsychotic Agents; Endocytosis; Female; Gene Expression Regulation; Genetic Association Studies; Genomics; Gyrus Cinguli; Haloperidol; Humans; Male; N-Methylaspartate; Nerve Tissue Proteins; Post-Synaptic Density; Proteomics; Rats; Reproducibility of Results; Schizophrenia; Signal Transduction; Synaptotagmins; Tandem Mass Spectrometry | 2015 |
Alpha7 nicotinic acetylcholine receptor agonists and PAMs as adjunctive treatment in schizophrenia. An experimental study.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Antidepressive Agents; Antipsychotic Agents; Benzamides; Bridged Bicyclo Compounds; Citalopram; Depression; Disease Models, Animal; Dopamine; Excitatory Amino Acid Agonists; Male; N-Methylaspartate; Nicotinic Agonists; Phenylurea Compounds; Prefrontal Cortex; Pyramidal Cells; Rats, Sprague-Dawley; Rats, Wistar; Risperidone; Schizophrenia; Schizophrenic Psychology; Selective Serotonin Reuptake Inhibitors | 2016 |
Characterization of SSR103800, a selective inhibitor of the glycine transporter-1 in models predictive of therapeutic activity in schizophrenia.
Topics: Animals; Antidepressive Agents; Antipsychotic Agents; Discrimination, Psychological; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Extracellular Space; Gerbillinae; Glycine; Glycine Plasma Membrane Transport Proteins; Male; Mice; Motor Activity; N-Methylaspartate; Phencyclidine; Recognition, Psychology; Reflex, Startle; Schizophrenia; Stereoisomerism; Swimming | 2008 |
Distinct forms of prepulse inhibition disruption distinguishable by the associated changes in prepulse-elicited reaction.
Topics: Acoustic Stimulation; Analysis of Variance; Animals; Hippocampus; Microinjections; Muscimol; N-Methylaspartate; Neural Inhibition; Rats; Reaction Time; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Sensory Gating | 2009 |
Neurophysiological and neurochemical animal models of schizophrenia: focus on glutamate.
Topics: Acoustic Stimulation; Amphetamine; Animals; Brain; Disease Models, Animal; Dopamine; Electroencephalography; Evoked Potentials, Auditory; Glutamic Acid; Haplorhini; Humans; Microdialysis; N-Methylaspartate; Rats; Schizophrenia; Schizophrenic Psychology; Synaptic Transmission | 2009 |
The glycine transport inhibitor sarcosine is an NMDA receptor co-agonist that differs from glycine.
Topics: Animals; Antipsychotic Agents; Calcium Signaling; Cell Death; Cells, Cultured; Electrophysiological Phenomena; Glycine; Glycine Plasma Membrane Transport Proteins; Hippocampus; Humans; Mice; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Receptors, N-Methyl-D-Aspartate; Sarcosine; Schizophrenia; Sodium | 2009 |
Disruption of mesolimbic regulation of prefrontal cholinergic transmission in an animal model of schizophrenia and normalization by chronic clozapine treatment.
Topics: Acetylcholine; Aging; Amphetamine; Animals; Animals, Newborn; Clozapine; Disease Models, Animal; Hippocampus; Ibotenic Acid; Male; Microinjections; N-Methylaspartate; Neural Pathways; Nucleus Accumbens; Prefrontal Cortex; Rats; Rats, Wistar; Schizophrenia; Time Factors | 2009 |
Potentiation of excitatory serotonergic responses by MK-801 in the medial prefrontal cortex.
Topics: Animals; Disease Models, Animal; Dizocilpine Maleate; Electrophysiology; Excitatory Amino Acid Antagonists; Iontophoresis; Male; N-Methylaspartate; Prefrontal Cortex; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2C; Schizophrenia; Serotonin; Synaptic Transmission | 2009 |
The role of the mGluR allosteric modulation in the NMDA-hypofunction model of schizophrenia.
Topics: Allosteric Regulation; Animals; Disease Models, Animal; Humans; Ketamine; N-Methylaspartate; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Schizophrenia | 2009 |
Delta oscillation and short-term plasticity in the rat medial prefrontal cortex: modelling NMDA hypofunction of schizophrenia.
Topics: Animals; Biphenyl Compounds; Delta Rhythm; Disease Models, Animal; Dizocilpine Maleate; Electric Stimulation; Electroencephalography; Excitatory Postsynaptic Potentials; Hippocampus; Lidocaine; Male; N-Methylaspartate; Neuronal Plasticity; Prefrontal Cortex; Quinazolines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Sulfonamides; Synaptic Transmission; Time Factors | 2011 |
The puzzle box as a simple and efficient behavioral test for exploring impairments of general cognition and executive functions in mouse models of schizophrenia.
Topics: Animals; Behavior, Animal; Cognition Disorders; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Executive Function; Gene Expression Regulation; Hippocampus; Kaplan-Meier Estimate; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Prefrontal Cortex; Problem Solving; Reaction Time; Receptors, AMPA; Receptors, Dopamine D2; Schizophrenia | 2011 |
Brain-specific Phgdh deletion reveals a pivotal role for L-serine biosynthesis in controlling the level of D-serine, an N-methyl-D-aspartate receptor co-agonist, in adult brain.
Topics: Animals; Brain; Chromatography, High Pressure Liquid; Female; Gene Deletion; Hippocampus; Humans; Male; Mice; Mice, Knockout; N-Methylaspartate; Phosphoglycerate Dehydrogenase; Phosphorylation; Schizophrenia; Serine | 2010 |
How feedback inhibition shapes spike-timing-dependent plasticity and its implications for recent Schizophrenia models.
Topics: Action Potentials; Animals; Cerebral Cortex; Feedback, Physiological; Glutamate Decarboxylase; Humans; Models, Neurological; N-Methylaspartate; Nerve Net; Neural Inhibition; Neuronal Plasticity; Neurons; Schizophrenia; Time Factors | 2011 |
[About the NMDA-system again].
Topics: Alcoholism; Alzheimer Disease; Animals; Antipsychotic Agents; Excitatory Amino Acid Agonists; Glutamic Acid; Humans; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Synapses | 2011 |
MicroRNA-132 dysregulation in schizophrenia has implications for both neurodevelopment and adult brain function.
Topics: Adult; Animals; Antipsychotic Agents; Bipolar Disorder; Brain; Cerebral Cortex; Databases, Genetic; Demography; Disease Models, Animal; DNA (Cytosine-5-)-Methyltransferases; DNA Methyltransferase 3A; GATA2 Transcription Factor; Gene Expression Regulation; HEK293 Cells; Humans; Mice; MicroRNAs; Muscle Proteins; N-Methylaspartate; Oligonucleotide Array Sequence Analysis; Open Reading Frames; Polymerase Chain Reaction; Rats; Receptors, N-Methyl-D-Aspartate; Reproducibility of Results; Schizophrenia; Signal Transduction | 2012 |
Lasp1 is down-regulated in NMDA receptor antagonist-treated mice and implicated in human schizophrenia susceptibility.
Topics: Adaptor Proteins, Signal Transducing; Adult; Animals; Cytoskeletal Proteins; Disease Models, Animal; Dizocilpine Maleate; Down-Regulation; Female; Genetic Predisposition to Disease; Homeodomain Proteins; Humans; LIM Domain Proteins; Male; Mice; Mice, Inbred ICR; Middle Aged; N-Methylaspartate; Polymorphism, Single Nucleotide; Promoter Regions, Genetic; Random Allocation; Republic of Korea; Schizophrenia | 2013 |
Effects of ketamine on leading saccades during smooth-pursuit eye movements may implicate cerebellar dysfunction in schizophrenia.
Topics: Adult; Cerebellum; Double-Blind Method; Female; Humans; Ketamine; Male; N-Methylaspartate; Placebos; Psychiatric Status Rating Scales; Pursuit, Smooth; Receptors, N-Methyl-D-Aspartate; Saccades; Schizophrenia; Synaptic Transmission | 2002 |
Olanzapine and clozapine but not haloperidol reverse subchronic phencyclidine-induced functional hyperactivity of N-methyl-D-aspartate receptors in pyramidal cells of the rat medial prefrontal cortex.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Antipsychotic Agents; Benzodiazepines; Clozapine; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Haloperidol; Male; Membrane Potentials; N-Methylaspartate; Olanzapine; Patch-Clamp Techniques; Phencyclidine; Pirenzepine; Prefrontal Cortex; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Schizophrenia | 2003 |
Latent inhibition is spared by N-methyl-D-aspartate (NMDA)-induced ventral hippocampal lesions, but is attenuated following local activation of the ventral hippocampus by intracerebral NMDA infusion.
Topics: Animals; Behavior, Animal; Conditioning, Psychological; Denervation; Excitatory Amino Acid Agonists; Hippocampus; Male; N-Methylaspartate; Neural Inhibition; Rats; Rats, Inbred Strains; Schizophrenia | 2004 |
The effects of ketamine vary among inbred mouse strains and mimic schizophrenia for the P80, but not P20 or N40 auditory ERP components.
Topics: Animals; Disease Models, Animal; Evoked Potentials, Auditory; Humans; Ketamine; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Inbred Strains; N-Methylaspartate; Schizophrenia; Species Specificity | 2004 |
Modulation of striatal dopamine release by glycine transport inhibitors.
Topics: Amino Acid Transport Systems, Neutral; Animals; Biphenyl Compounds; Corpus Striatum; Dopamine; Excitatory Amino Acid Agonists; GABA Antagonists; GABA-B Receptor Antagonists; Glycine; Glycine Plasma Membrane Transport Proteins; Mice; Mice, Inbred BALB C; N-Methylaspartate; Organ Culture Techniques; Presynaptic Terminals; Receptors, GABA-B; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Sarcosine; Schizophrenia; Synaptic Transmission | 2005 |
[Neurobiological aspects of bipolar disorder].
Topics: Amygdala; Bipolar Disorder; Brain-Derived Neurotrophic Factor; Cognition Disorders; Diagnosis, Differential; Hippocampus; Humans; N-Methylaspartate; Neuropsychological Tests; Prefrontal Cortex; Psychotic Disorders; Schizophrenia | 2005 |
Post-pubertal disruption of medial prefrontal cortical dopamine-glutamate interactions in a developmental animal model of schizophrenia.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Disease Models, Animal; Dopamine; Dopamine Agonists; Electrophysiology; Excitatory Amino Acid Agonists; Female; Glutamic Acid; Hippocampus; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Prefrontal Cortex; Pregnancy; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Schizophrenia | 2007 |
Encoding vs. retention: differential effects of cue manipulation on working memory performance in schizophrenia.
Topics: Adult; Cues; Diagnostic and Statistical Manual of Mental Disorders; Dopamine; Female; Humans; Male; Memory Disorders; Memory, Short-Term; N-Methylaspartate; Neuropsychological Tests; Retention, Psychology; Schizophrenia; Severity of Illness Index | 2007 |
Memantine-associated reversal of clozapine-induced weight gain.
Topics: Adult; Antipsychotic Agents; Clozapine; Dopamine Agents; Humans; Male; Memantine; N-Methylaspartate; Obesity; Schizophrenia | 2007 |
A glutathione deficit alters dopamine modulation of L-type calcium channels via D2 and ryanodine receptors in neurons.
Topics: Animals; Blotting, Western; Buthionine Sulfoximine; Calcium Channels, L-Type; Dopamine; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Glutathione; Mice; N-Methylaspartate; Neurons; Receptors, Dopamine D2; Ryanodine Receptor Calcium Release Channel; Schizophrenia | 2008 |
Expression of neuronal nitric oxide synthase in the hippocampal formation in affective disorders.
Topics: Adult; Bipolar Disorder; Case-Control Studies; Depressive Disorder, Major; Female; Hippocampus; Humans; Immunohistochemistry; Male; Middle Aged; N-Methylaspartate; Nitric Oxide Synthase Type I; Schizophrenia; Signal Transduction | 2008 |
Phenomenology, aetiology and treatment of schizophrenia.
Topics: Cognition Disorders; Growth Substances; Hearing Disorders; Humans; N-Methylaspartate; Schizophrenia; Schizophrenic Psychology | 2008 |
Antipsychotic agents antagonize non-competitive N-methyl-D-aspartate antagonist-induced behaviors.
Topics: Amphetamine; Animals; Antipsychotic Agents; Behavior, Animal; Dizocilpine Maleate; Dopamine; Dose-Response Relationship, Drug; Male; Mice; N-Methylaspartate; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Social Behavior | 1995 |
Serine and glycine metabolism in schizophrenic patients.
Topics: Adult; Glycine; Glycine Hydroxymethyltransferase; Humans; Male; N-Methylaspartate; Schizophrenia; Serine | 1993 |
Regulation of [3H] dopamine release from mesolimbic and mesocortical areas of guinea pig brain by sigma receptors.
Topics: Analgesics; Analysis of Variance; Animals; Cyclohexylamines; Dopamine; Dopamine Antagonists; Guinea Pigs; Haloperidol; N-Methylaspartate; Nucleus Accumbens; Pentazocine; Prefrontal Cortex; Pyrrolidines; Receptors, sigma; Schizophrenia | 1996 |
D-serine and the therapeutic challenge posed by the N-methyl-D-aspartate antagonist model of schizophrenia.
Topics: Glycine; Humans; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Serine | 1998 |
Oxytocin modulates psychotomimetic-induced deficits in sensorimotor gating.
Topics: Amphetamine; Analysis of Variance; Animals; Apomorphine; Dizocilpine Maleate; Dopamine; Dopamine Agonists; Dose-Response Relationship, Drug; Drug Interactions; Hallucinogens; Male; N-Methylaspartate; Oxytocin; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Reflex, Startle; Schizophrenia | 1999 |
A.E. Bennett Research Award. Reversal of phencyclidine-induced effects by glycine and glycine transport inhibitors.
Topics: Animals; Awards and Prizes; Brain; Dopamine; Glycine Agents; Hallucinogens; Male; Microdialysis; N-Methylaspartate; Neurotransmitter Uptake Inhibitors; Phencyclidine; Psychiatry; Rats; Rats, Sprague-Dawley; Schizophrenia; Time Factors | 1999 |
Neurotransmitter interactions in schizophrenia-therapeutic implications.
Topics: Brain; Dopamine; Dopamine Agents; Glutamic Acid; Humans; N-Methylaspartate; Neuroprotective Agents; Receptors, GABA; Schizophrenia; Synaptic Transmission | 1999 |
Inhibition of striatal dopamine release by glycine and glycyldodecylamide.
Topics: Aminoquinolines; Animals; Corpus Striatum; Dopamine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Mice; N-Methylaspartate; Neurons; Phencyclidine; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Subcellular Fractions; Tritium | 2000 |
Potentiation of DOM-induced stimulus control by non-competitive NMDA antagonists: a link between the glutamatergic and serotonergic hypotheses of schizophrenia.
Topics: Animals; Discrimination Learning; Disease Models, Animal; Dizocilpine Maleate; DOM 2,5-Dimethoxy-4-Methylamphetamine; Dose-Response Relationship, Drug; Drug Synergism; Excitatory Amino Acid Antagonists; Hallucinogens; Ketamine; Male; N-Methylaspartate; Phencyclidine; Rats; Rats, Inbred F344; Schizophrenia | 2000 |
Hyperactivity and disruption of prepulse inhibition induced by N-methyl-D-aspartate stimulation of the ventral hippocampus and the effects of pretreatment with haloperidol and clozapine.
Topics: Animals; Clozapine; Dopamine Antagonists; Excitatory Amino Acid Agonists; Haloperidol; Hippocampus; Hyperkinesis; Male; Motor Activity; N-Methylaspartate; Neural Inhibition; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Reflex, Startle; Schizophrenia; Serotonin Antagonists | 2001 |
Regulation of sensorimotor gating in rats by hippocampal NMDA: anatomical localization.
Topics: Animals; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Glutamic Acid; Hippocampus; Male; N-Methylaspartate; Neural Inhibition; Neural Pathways; Neurons; Rats; Rats, Sprague-Dawley; Reflex, Startle; Schizophrenia | 2001 |
N-methyl-D-aspartate antagonists, schizophrenia, and neuroleptic malignant syndrome.
Topics: Dopamine; Humans; N-Methylaspartate; Neuroleptic Malignant Syndrome; Parkinson Disease; Receptors, N-Methyl-D-Aspartate; Schizophrenia | 1992 |
Quantitative autoradiographic analysis of glutamate binding sites in the hippocampal formation in normal and schizophrenic brain post mortem.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Adult; Aged; Autoradiography; Female; Glutamates; Hippocampus; Humans; Kainic Acid; Male; Middle Aged; N-Methylaspartate; Pyramidal Tracts; Quinoxalines; Receptors, Glutamate; Receptors, Neurotransmitter; Reference Values; Schizophrenia; Tritium | 1990 |