n-methylaspartate has been researched along with Retinal Diseases in 74 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (2.70) | 18.2507 |
| 2000's | 28 (37.84) | 29.6817 |
| 2010's | 34 (45.95) | 24.3611 |
| 2020's | 10 (13.51) | 2.80 |
| Authors | Studies |
|---|---|
| Cebulla, CM; Hamadmad, S; Heisler-Taylor, T; Racine, J; Shah, MH; Urbanski, EG; Wan, R; Wilson, H | 1 |
| Fujita, K; Ge, S; Himori, N; Maekawa, S; Nakazawa, T; Nishiguchi, KM; Ohno-Oishi, M; Omodaka, K; Ozawa, M; Sato, K; Sato, T; Shiga, Y; Yabana, T; Yasuda, M | 1 |
| Hu, FY; Liu, HL; Wu, JH; Xu, P | 1 |
| Abd Ghapor, AA; Abdul Nasir, NA; Agarwal, R; Iezhitsa, I | 1 |
| Dvoriantchikova, G; Fleishaker, M; Ivanov, D | 1 |
| Ishimaru, Y; Maeda, S; Shibagaki, F; Sumino, A; Yamamuro, A; Yoshioka, Y | 1 |
| Gotoh, N; Hasegawa, T; Iida, K; Ikeda, HO; Iwai, S; Kakizuka, A; Nakano, N; Tsujikawa, A | 1 |
| Gammon, ST; Jacobsen, MC; Le Roux, LG; Pagel, MD; Piwnica-Worms, DR; Qiu, X; Schellingerhout, D | 1 |
| Fujishita, S; Igarashi, T; Kameya, S; Kobayashi, M; Nakamoto, K; Okada, T; Shiozawa, AL; Takahashi, H | 1 |
| Asano, D; Ishii, K; Mori, A; Morita, A; Nakahara, T; Sakamoto, K; Ushikubo, H; Watanabe, K | 1 |
| Daigaku, R; Fujita, K; Maekawa, S; Maruyama, K; Moritoh, S; Murayama, N; Nakazawa, T; Nishiguchi, KM; Omodaka, K; Sato, K; Shiga, Y; Tawarayama, H; Yabana, T | 1 |
| Estrada-Leyva, B; Lamas, M; Quintero, H; Reyes-Aguirre, LI | 1 |
| Agarwal, P; Agarwal, R; Iezhitsa, I; Ismail, NM; Jafri, AJA | 1 |
| Chauhan, BC; Hooper, ML; Smith, CA | 1 |
| Ahn, HR; Jung, SH; Kim, KA; Shim, SH | 1 |
| Ishii, K; Kurauchi, Y; Mori, A; Nakahara, T; Naruoka, T; Nishihira, J; Sakamoto, K; Tsuda, Y | 1 |
| Ishii, K; Kurauchi, Y; Mori, A; Nakahara, T; Sakamoto, K | 1 |
| Ahn, HR; Jang, H; Jung, SH; Kim, CY; Kim, KA; Lee, CY; Lee, HJ; Nho, CW; Pan, CH | 1 |
| Ishii, K; Kuroki, T; Mori, A; Nakahara, T; Sakamoto, K | 1 |
| Seitz, R; Tamm, ER | 1 |
| Cai, SP; Fan, N; Guo, L; Kaufman, PL; Liu, X; Wang, Y; Yang, Q; Yin, Y; Zhou, X | 1 |
| Chen, Z; Lei, B; Lei, C; Yang, H; Zheng, C; Zheng, S | 1 |
| Boriushkin, E; Jing, G; Li, J; Seigel, GM; Wang, JJ; Zhang, SX | 1 |
| Aoki, Y; Asano, D; Ishii, K; Mori, A; Nakahara, T; Sakamoto, K; Ushikubo, H | 1 |
| Bilonick, RA; Chan, KC; Conner, IP; Ho, LC; Kim, SG; Schuman, JS; Sigal, IA; van der Merwe, Y; Wang, B; Wollstein, G; Wu, EX | 1 |
| Fujimura, K; Ishii, K; Kurauchi, Y; Mizuta, A; Mori, A; Nakahara, T; Sakamoto, K | 1 |
| Aoki, Y; Asano, D; Hayashi, I; Ishii, K; Mori, A; Nakahara, T; Sakamoto, K; Ushikubo, H | 1 |
| Agostini, RM; Binda, NS; Carayon, CP; Cordeiro, MN; da Silva Junior, CA; de Castro Junior, CJ; Gomez, MV; Guimarães, AL; Pereira, EM; Pinheiro, AC; Silva, JF; Silva, MA | 1 |
| Chen, T; Dang, X; Huo, F; Lv, B; Xu, Z; Yang, X; Zhang, T | 1 |
| Agudo-Barriuso, M; Galindo-Romero, C; Hallböök, F; Harun-Or-Rashid, M; Jiménez-López, M; Vidal-Sanz, M | 1 |
| Agarwal, P; Agarwal, R; Arfuzir, NNN; Demidov, V; Iezhitsa, I; Ismail, NM; Jafri, AJA; Kharitonova, M; Krasilnikova, A; Lambuk, L; Razali, N; Serebryansky, E; Skalny, A; Spasov, A; Yusof, APM | 1 |
| Hirooka, K; Kobayashi, M; Nakano, Y; Nishiyama, A; Ono, A; Tsujikawa, A | 1 |
| Aihara, M; Araie, M; Hara, H; Imaizumi, K; Inokuchi, Y; Kubo, M; Kudo, T; Kurita, T; Nakajima, Y; Saito, A; Sajiki, H; Shimazawa, M | 1 |
| Hara, H; Inokuchi, Y; Ishibashi, T; Nakajima, Y; Otsubo, K; Shimazawa, M | 1 |
| Ishii, K; Kawakami, T; Kuwagata, M; Nakahara, T; Saito, M; Sakamoto, K; Shimada, M; Yamaguchi, A | 1 |
| Aihara, M; Araie, M; Hara, H; Imai, S; Inokuchi, Y; Nakajima, Y; Shimazawa, M | 1 |
| Araie, M; Hara, H; Ito, Y; Nakamura, S; Shimazawa, M; Tanaka, H; Tsuruma, K | 1 |
| Lipton, SA; Manabe, S; Seki, M; Soussou, W | 1 |
| Agey, P; Dong, CJ; Guo, Y; Hare, WA; Wheeler, L | 1 |
| Bessero, AC; Bonny, C; Chiodini, F; Clarke, PG; Rungger-Brändle, E | 1 |
| Akane, M; Hara, H; Inokuchi, Y; Shimazawa, M; Tsuruma, K | 1 |
| Akane, M; Fujisawa, T; Hara, H; Hironaka, K; Inokuchi, Y; Shimazaki, H; Shimazawa, M; Takeuchi, H; Tozuka, Y; Tsuruma, K | 1 |
| Chan, HH; Chu, PH; Ho, WC; Lung, JC; Ng, YF; So, KF; Ting, PW; To, CH | 1 |
| Aihara, M; Hara, H; Ito, Y; Miwa, A; Shimazawa, M; Tsuruma, K | 1 |
| Akanuma, K; Ishii, K; Mori, A; Nakahara, T; Oikawa, F; Sakamoto, K; Ueda, K | 1 |
| Ishii, K; Mori, A; Nakahara, T; Sakamoto, K; Tsuda, Y; Ueda, K | 1 |
| Aktan, G; Avcıoglu, S; Gokce, FM; Kaya, M; Onder, HI; Tunc, M; Yıldırım, U; Yuksel, H | 1 |
| Ishii, K; Mori, A; Nakahara, T; Sakamoto, K; Ueda, K | 1 |
| Chidlow, G; Melena, J; Osborne, NN; Schmidt, KG; Wood, JP | 1 |
| Hirata, A; Inomata, Y; Kido, N; Koga, T; Tanihara, H; Yonemura, N | 1 |
| Chang, SY; Choi, JS; Chung, JM; Gwag, BJ; Joo, CK; Lee, YA; Noh, JH; Ryu, BR; Won, SJ; Yoon, SH | 1 |
| Altuntaş, I; Kaya, M; Ozdemir, T; Tunç, M | 1 |
| Hara, A; Kozawa, O; Kumada, M; Matsuno, H; Matsuo, O; Mori, H; Niwa, M; Wang, X; Yamamoto, T | 1 |
| Fletcher, EL | 1 |
| Isenoumi, K; Kitaoka, Y; Kobayashi, S; Kogo, J; Kumai, T; Kuribayashi, K; Lam, TT; Motoki, M; Munemasa, Y; Ueno, S | 1 |
| Fischer, AJ; Omar, G; Reh, TA; Schmidt, M | 1 |
| Bennett, J; Dejneka, NS; Klein, RL; Meyer, EM; Naskar, R; Orlin, A; Quinto, K; Schuettauf, F; Vorwerk, C; Zurakowski, D | 1 |
| Goto, W; Hara, H; Ikeda, T; Kobayashi, T; Oku, H; Okuno, T; Ota, T; Sugiyama, T; Yoneda, S | 1 |
| Caprioli, J; Chiu, K; Kwong Kwong, JM; Lam, TT; Ying Li, WW | 1 |
| Agarwal, N; Hara, H; Shimazawa, M; Yamashima, T | 1 |
| Fukushima, M; Inoue, T; Mawatari, Y; Setoguchi, T; Taga, T; Tanihara, H | 1 |
| Awai, M; Gotoh, T; Inomata, Y; Koga, T; Mori, M; Oyadomari, S; Tanihara, H | 1 |
| Inomata, Y; Kawaji, T; Kondo, N; Nakamura, H; Tanihara, H; Tanito, M; Teratani, A; Yodoi, J | 1 |
| Akaike, A; Hama, Y; Katsuki, H; Kume, T; Suminaka, C; Tochikawa, Y | 1 |
| Hara, H; Kawase, K; Nagase, H; Satoh, M; Shimazawa, M; Suemori, S; Yamamoto, T | 1 |
| Hara, H; Inokuchi, Y; Ito, Y; Shimazawa, M | 1 |
| Endo, S; Nakazawa, T; Nishida, K; Pagès, G; Pouysségur, J; Ryu, M; Shimura, M | 1 |
| Casson, RJ; Chidlow, G; Manavis, J; Osborne, NN; Wood, JP | 1 |
| Araie, M; Fukumitsu, H; Furukawa, S; Hara, H; Inokuchi, Y; Ito, Y; Shimazawa, M | 1 |
| Barnstable, CJ; Fu, XY; Kawasaki, A; Li, H; Liu, MG; Shao-Min Zhang, S; Zhang, C | 1 |
| Chang, YC; Gean, PW; Hon, YS; Sue, TY; Tyan, SH | 1 |
| Bae, JH; Chidlow, G; DeSantis, L; Nash, MS; Osborne, NN; Ugarte, M; Wood, JP | 1 |
| Hashimoto, T; Ono, Y; Saito, N; Sakai, N; Shirai, Y; Sumioka, K; Takahashi, M; Tanaka, C; Yamamoto, M | 1 |
| Burakgazi, E; Chalmers-Redman, R; Danias, J; Mittag, TW; Podos, SM; Pohorenec, G; Tatton, WG; Yuan, HM | 1 |
1 review(s) available for n-methylaspartate and Retinal Diseases
| Article | Year |
|---|---|
Neurovascular interactions in the retina: physiological and pathological roles.
Topics: Angiotensin II; Catecholamines; Cell Communication; Diabetic Retinopathy; Disease Progression; Drug Discovery; Endothelin Receptor Antagonists; Endothelin-1; Glaucoma; Homeostasis; Molecular Targeted Therapy; N-Methylaspartate; Neuroglia; Neurons; Nitric Oxide; Nitric Oxide Synthase Type II; Potassium Channels, Calcium-Activated; Receptors, GABA; Retina; Retinal Diseases; Retinal Vessels | 2013 |
73 other study(ies) available for n-methylaspartate and Retinal Diseases
| Article | Year |
|---|---|
Multimodal imaging and functional analysis of the chick NMDA retinal damage model.
Topics: Animals; Chickens; Disease Models, Animal; Electroretinography; Fundus Oculi; Imaging, Three-Dimensional; Intraocular Pressure; Multimodal Imaging; N-Methylaspartate; Retina; Retinal Diseases; Tomography, Optical Coherence | 2021 |
CHOP deletion and anti-neuroinflammation treatment with hesperidin synergistically attenuate NMDA retinal injury in mice.
Topics: Animals; Blotting, Western; Calcium-Binding Proteins; Cytokines; Disease Models, Animal; Drug Synergism; Gene Deletion; Hesperidin; Immunohistochemistry; In Situ Nick-End Labeling; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microfilament Proteins; Microglia; N-Methylaspartate; Neuroprotection; NF-kappa B; Oxidative Stress; Real-Time Polymerase Chain Reaction; Retinal Diseases; Retinal Ganglion Cells; Transcription Factor CHOP | 2021 |
Regulation of mitophagy by metformin improves the structure and function of retinal ganglion cells following excitotoxicity-induced retinal injury.
Topics: Animals; Apoptosis; Eye Injuries; Lactate Dehydrogenases; Metformin; Mitophagy; N-Methylaspartate; Rats; Retinal Diseases; Retinal Ganglion Cells | 2022 |
Intravitreal
Topics: Animals; Apoptosis; Carcinoma, Renal Cell; Eye Injuries; Kidney Neoplasms; N-Methylaspartate; Optic Nerve; Optic Nerve Injuries; Rats; Rats, Sprague-Dawley; Resveratrol; Retina; Retinal Diseases | 2022 |
Molecular mechanisms of NMDA excitotoxicity in the retina.
Topics: Animals; Free Radicals; Inflammation; Iron; Mice; N-Methylaspartate; Necrosis; Retina; Retinal Diseases | 2023 |
Systemic Administration of an Apelin Receptor Agonist Prevents NMDA-Induced Loss of Retinal Neuronal Cells in Mice.
Topics: Administration, Oral; Animals; Apelin Receptors; Imines; Injections, Intraperitoneal; Intravitreal Injections; Male; Mesylates; Mice, Inbred C57BL; N-Methylaspartate; Phosphorylation; Proto-Oncogene Proteins c-akt; Retinal Diseases; Retinal Neurons | 2020 |
Effect of VCP modulators on gene expression profiles of retinal ganglion cells in an acute injury mouse model.
Topics: Acute Disease; Animals; Apoptosis; Biomarkers; Computational Biology; Disease Models, Animal; Disease Susceptibility; Energy Metabolism; Gene Expression Profiling; Gene Ontology; Immunophenotyping; Metabolic Networks and Pathways; Mice; N-Methylaspartate; Retinal Diseases; Retinal Ganglion Cells; Transcriptome; Valosin Containing Protein | 2020 |
Axonal Transport as an In Vivo Biomarker for Retinal Neuropathy.
Topics: Animals; Axonal Transport; Axons; Biomarkers; Disease Models, Animal; Endocytosis; Male; N-Methylaspartate; Rats, Inbred BN; Retina; Retinal Diseases; Retinal Ganglion Cells; Synapses; Tetanus Toxin | 2020 |
Tyrosine triple mutated AAV2-BDNF gene therapy in an inner retinal injury model induced by intravitreal injection of
Topics: Animals; Brain-Derived Neurotrophic Factor; Dependovirus; Disease Models, Animal; Electroretinography; Gene Expression; Genetic Therapy; Genetic Vectors; Immunohistochemistry; Intravitreal Injections; Mice; Mice, Inbred C57BL; N-Methylaspartate; Recombinant Proteins; Retinal Diseases | 2020 |
Metformin Protects against NMDA-Induced Retinal Injury through the MEK/ERK Signaling Pathway in Rats.
Topics: Animals; Excitatory Amino Acid Agonists; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation, Enzymologic; Hypoglycemic Agents; Male; Metformin; Mitogen-Activated Protein Kinase Kinases; N-Methylaspartate; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Retinal Diseases; Signal Transduction | 2021 |
The neuroprotective effect of hesperidin in NMDA-induced retinal injury acts by suppressing oxidative stress and excessive calpain activation.
Topics: Animals; Apoptosis; Calpain; Cells, Cultured; Disease Models, Animal; Evoked Potentials, Visual; Hesperidin; Male; Mice; N-Methylaspartate; Neuroprotective Agents; Oxidative Stress; Retina; Retinal Diseases; Retinal Ganglion Cells; Treatment Outcome; Tumor Necrosis Factor-alpha | 2017 |
In Vitro Assays for Mouse Müller Cell Phenotyping Through microRNA Profiling in the Damaged Retina.
Topics: Animals; Disease Models, Animal; Ependymoglial Cells; Excitatory Amino Acid Transporter 1; Gene Expression Profiling; Humans; Immunomagnetic Separation; Intravitreal Injections; Mice; Mice, Inbred C57BL; MicroRNAs; N-Methylaspartate; Real-Time Polymerase Chain Reaction; Retinal Diseases; Reverse Transcriptase Polymerase Chain Reaction | 2018 |
Taurine protects against NMDA-induced retinal damage by reducing retinal oxidative stress.
Topics: Animals; Apoptosis; Excitatory Amino Acid Agonists; Female; Male; N-Methylaspartate; Oxidation-Reduction; Oxidative Stress; Protective Agents; Rats; Rats, Sprague-Dawley; Retinal Diseases; Retinaldehyde; Taurine | 2019 |
Optical Coherence Tomography Angiography in Mice: Quantitative Analysis After Experimental Models of Retinal Damage.
Topics: Animals; Female; Fluorescein Angiography; Intravitreal Injections; Light; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Transgenic; Models, Animal; N-Methylaspartate; Nerve Crush; Optic Nerve Injuries; Radiation Injuries, Experimental; Reproducibility of Results; Retina; Retinal Diseases; Retinal Ganglion Cells; Retinal Vessels; Tomography, Optical Coherence | 2019 |
Protective effects of the compounds isolated from the seed of Psoralea corylifolia on oxidative stress-induced retinal damage.
Topics: Animals; Cell Line; Cell Survival; Male; Mice; Mice, Inbred ICR; Molecular Structure; N-Methylaspartate; Optic Nerve; Oxidative Stress; Phenols; Plant Extracts; Psoralea; Rats; Rats, Sprague-Dawley; Retina; Retinal Diseases; Seeds | 2013 |
ISO-1, a macrophage migration inhibitory factor antagonist, prevents N-methyl-D-aspartate-induced retinal damage.
Topics: Animals; Catalytic Domain; Isoxazoles; Macrophage Migration-Inhibitory Factors; Male; N-Methylaspartate; Neurons; Rats; Rats, Sprague-Dawley; Retinal Diseases | 2013 |
Hydroxycinnamic acids in Crepidiastrum denticulatum protect oxidative stress-induced retinal damage.
Topics: Animals; Apoptosis; Asteraceae; Caffeic Acids; Chlorogenic Acid; Coumaric Acids; Disease Models, Animal; Glaucoma; Lipid Peroxidation; Male; Mice; Mice, Inbred ICR; N-Methylaspartate; Nerve Crush; Neuroprotective Agents; Optic Nerve; Oxidative Stress; Plant Extracts; Rats; Rats, Sprague-Dawley; Retinal Diseases; Succinates | 2014 |
Histological protection by nilvadipine against neurotoxicity induced by NOC12, a nitric oxide donor, in the rat retina.
Topics: Animals; Antioxidants; Excitatory Amino Acid Agonists; Male; N-Methylaspartate; Neuroprotective Agents; Neurotoxicity Syndromes; Nifedipine; Nitric Oxide Donors; Nitroso Compounds; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Retina; Retinal Diseases | 2014 |
Müller cells and microglia of the mouse eye react throughout the entire retina in response to the procedure of an intravitreal injection.
Topics: Animals; Disease Models, Animal; Ependymoglial Cells; Excitatory Amino Acid Agonists; Gliosis; Intravitreal Injections; Mice; Mice, Inbred Strains; Microglia; N-Methylaspartate; Retina; Retinal Diseases | 2014 |
Neuroprotective effects of C3 exoenzyme in excitotoxic retinopathy.
Topics: ADP Ribose Transferases; Analysis of Variance; Animals; Apoptosis; Botulinum Toxins; Cell Survival; Disease Models, Animal; Intravitreal Injections; Male; Mice; N-Methylaspartate; Neuroprotective Agents; NIH 3T3 Cells; Rats; Rats, Sprague-Dawley; Retina; Retinal Diseases; Retinal Ganglion Cells; rhoA GTP-Binding Protein | 2014 |
Activation of liver X receptor protects inner retinal damage induced by N-methyl-D-aspartate.
Topics: Animals; Apoptosis; Blotting, Western; Disease Models, Animal; Electroretinography; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation; Immunohistochemistry; In Situ Nick-End Labeling; Liver X Receptors; Mice; Mice, Inbred C57BL; N-Methylaspartate; Orphan Nuclear Receptors; Real-Time Polymerase Chain Reaction; Retina; Retinal Diseases; RNA, Messenger | 2015 |
Identification of p58IPK as a novel neuroprotective factor for retinal neurons.
Topics: Animals; Apoptosis; Cell Survival; Cells, Cultured; Disease Models, Animal; Endoplasmic Reticulum Stress; Gene Expression Regulation; HSP40 Heat-Shock Proteins; Immunoblotting; In Situ Nick-End Labeling; Mice; Mice, Knockout; N-Methylaspartate; Neurons; Real-Time Polymerase Chain Reaction; Retinal Diseases; Retinal Ganglion Cells; RNA | 2015 |
Preventive effects of rapamycin on inflammation and capillary degeneration in a rat model of NMDA-induced retinal injury.
Topics: Animals; Anti-Inflammatory Agents; Capillaries; Male; N-Methylaspartate; Rats, Sprague-Dawley; Retinal Diseases; Sirolimus | 2015 |
In Vivo Evaluation of White Matter Integrity and Anterograde Transport in Visual System After Excitotoxic Retinal Injury With Multimodal MRI and OCT.
Topics: Animals; Magnetic Resonance Imaging; Mice; Mice, Inbred C57BL; Multimodal Imaging; N-Methylaspartate; Optic Nerve Diseases; Rats; Rats, Sprague-Dawley; Retinal Diseases; Tomography, Optical Coherence; Visual Pathways; White Matter | 2015 |
High-mobility group Box-1 is involved in NMDA-induced retinal injury the in rat retina.
Topics: Animals; Apoptosis; Cell Death; Disease Models, Animal; HMGB1 Protein; Male; N-Methylaspartate; Oxidative Stress; Rats; Rats, Sprague-Dawley; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Retina; Retinal Diseases; Retinal Ganglion Cells | 2015 |
Protective Effects of Everolimus against N-Methyl-D-aspartic Acid-Induced Retinal Damage in Rats.
Topics: Animals; Disease Models, Animal; Everolimus; Extracellular Signal-Regulated MAP Kinases; In Situ Nick-End Labeling; Inflammation; Intravitreal Injections; Leukocyte Common Antigens; Male; N-Methylaspartate; Neuroprotective Agents; Phosphorylation; Protein Kinase Inhibitors; Rats, Sprague-Dawley; Retina; Retinal Diseases; Retinal Ganglion Cells; Sirolimus; TOR Serine-Threonine Kinases | 2015 |
PhTx3-4, a Spider Toxin Calcium Channel Blocker, Reduces NMDA-Induced Injury of the Retina.
Topics: Animals; Calcium Channel Blockers; Electroretinography; Glutamic Acid; Lipid Peroxidation; Male; N-Methylaspartate; Neuropeptides; Neuroprotective Agents; Rats, Wistar; Reactive Oxygen Species; Retinal Diseases; Spider Venoms; Vitreous Body | 2016 |
Puerarin Attenuates N-Methyl-D-aspartic Acid-induced Apoptosis and Retinal Ganglion Cell Damage Through the JNK/p38 MAPK Pathway.
Topics: Animals; Animals, Newborn; Apoptosis; Blotting, Western; Cells, Cultured; Gene Expression Regulation, Developmental; Intraocular Pressure; Isoflavones; Male; N-Methylaspartate; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Real-Time Polymerase Chain Reaction; Retinal Diseases; Retinal Ganglion Cells; RNA | 2016 |
Neuroprotection by α2-Adrenergic Receptor Stimulation after Excitotoxic Retinal Injury: A Study of the Total Population of Retinal Ganglion Cells and Their Distribution in the Chicken Retina.
Topics: Animals; Chick Embryo; Chickens; N-Methylaspartate; Neuroprotection; Receptors, Adrenergic, alpha-2; Retina; Retinal Diseases; Retinal Ganglion Cells; Transcription Factor Brn-3A | 2016 |
Protective effect of magnesium acetyltaurate against NMDA-induced retinal damage involves restoration of minerals and trace elements homeostasis.
Topics: Animals; Female; Homeostasis; Male; Minerals; N-Methylaspartate; Protective Agents; Rats; Rats, Sprague-Dawley; Retinal Diseases; Taurine; Trace Elements | 2017 |
The Relationship Between the Renin-Angiotensin-Aldosterone System and NMDA Receptor-Mediated Signal and the Prevention of Retinal Ganglion Cell Death.
Topics: Aldosterone; Animals; Apoptosis; Cell Count; Disease Models, Animal; Excitatory Amino Acid Agonists; Intravitreal Injections; Male; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Renin-Angiotensin System; Retinal Diseases; Retinal Ganglion Cells; Vitreous Body | 2017 |
Effect of an inducer of BiP, a molecular chaperone, on endoplasmic reticulum (ER) stress-induced retinal cell death.
Topics: Animals; Apoptosis; Blotting, Western; Cell Line; Dose-Response Relationship, Drug; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Gene Expression Regulation; Heat-Shock Proteins; In Situ Nick-End Labeling; Male; Mice; Mice, Transgenic; Molecular Chaperones; N-Methylaspartate; Rats; Retinal Diseases; Retinal Ganglion Cells; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiocyanates; Time Factors; Transcription Factor CHOP; Tunicamycin | 2009 |
Astaxanthin, a dietary carotenoid, protects retinal cells against oxidative stress in-vitro and in mice in-vivo.
Topics: Animals; Apoptosis; Carrier Proteins; Cell Survival; Cells, Cultured; Chromans; Dose-Response Relationship, Drug; Ferric Compounds; Fluoresceins; Hydrogen Peroxide; Hydroxyl Radical; In Situ Nick-End Labeling; Lipid Peroxidation; Male; Mice; Mice, Inbred Strains; N-Methylaspartate; Oxidative Stress; Phosphate-Binding Proteins; Rats; Reactive Oxygen Species; Retina; Retinal Diseases; Retinal Ganglion Cells; Xanthophylls | 2008 |
Histological protection by cilnidipine, a dual L/N-type Ca(2+) channel blocker, against neurotoxicity induced by ischemia-reperfusion in rat retina.
Topics: Amlodipine; Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, N-Type; Dihydropyridines; Drug Evaluation, Preclinical; In Situ Nick-End Labeling; Injections; Injections, Intravenous; Male; N-Methylaspartate; Neuroprotective Agents; Nitroso Compounds; omega-Conotoxins; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Retinal Degeneration; Retinal Diseases; Vitreous Body | 2009 |
Edaravone, a free radical scavenger, protects against retinal damage in vitro and in vivo.
Topics: Animals; Antipyrine; Cell Line; Cell Survival; Culture Media; Disease Models, Animal; Dose-Response Relationship, Drug; Edaravone; Free Radical Scavengers; Free Radicals; Green Fluorescent Proteins; Male; Mice; Mice, Transgenic; N-Methylaspartate; Oxidative Stress; Rats; Retinal Diseases; Retinal Ganglion Cells; Thy-1 Antigens | 2009 |
Lomerizine, a Ca2+ channel blocker, protects against neuronal degeneration within the visual center of the brain after retinal damage in mice.
Topics: Animals; Calcium Channel Blockers; Disease Models, Animal; Geniculate Bodies; Male; Mice; Mice, Inbred C57BL; N-Methylaspartate; Nerve Degeneration; Phosphopyruvate Hydratase; Piperazines; Proto-Oncogene Proteins c-fos; Retinal Diseases; Retinal Ganglion Cells; Statistics, Nonparametric; Superior Colliculi; Time Factors; Visual Pathways | 2010 |
Protection of retinal ganglion cells by caspase substrate-binding peptide IQACRG from N-methyl-D-aspartate receptor-mediated excitotoxicity.
Topics: Animals; Apoptosis; Blotting, Western; Caspase 3; Caspase 7; Caspase Inhibitors; Cell Survival; Cells, Cultured; Electrophysiology; Excitatory Amino Acid Agonists; Fluorescent Antibody Technique, Indirect; Immunoenzyme Techniques; In Situ Nick-End Labeling; Injections; Male; Matrix Metalloproteinase 9; MEF2 Transcription Factors; Myogenic Regulatory Factors; N-Methylaspartate; Neuroprotective Agents; Oligopeptides; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Retinal Diseases; Retinal Ganglion Cells; Vitreous Body | 2010 |
Nimodipine enhancement of alpha2 adrenergic modulation of NMDA receptor via a mechanism independent of Ca2+ channel blocking.
Topics: Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Calcium; Calcium Channel Blockers; Excitatory Amino Acid Agonists; Injections; Male; Microscopy, Confocal; N-Methylaspartate; Nimodipine; Patch-Clamp Techniques; Quinoxalines; Rabbits; Rats; Rats, Inbred BN; Receptors, Adrenergic, alpha-2; Receptors, N-Methyl-D-Aspartate; Retinal Diseases; Retinal Ganglion Cells; Vitreous Body | 2010 |
Role of the c-Jun N-terminal kinase pathway in retinal excitotoxicity, and neuroprotection by its inhibition.
Topics: Adaptation, Ocular; Animals; Blotting, Western; Calpain; Carrier Proteins; Cell Count; Cell Death; Electroretinography; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Immunohistochemistry; Injections; JNK Mitogen-Activated Protein Kinases; Male; Microfilament Proteins; N-Methylaspartate; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Retina; Retinal Diseases; Signal Transduction; Vitreous Body | 2010 |
SUN N8075, a novel radical scavenger, protects against retinal cell death in mice.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Aniline Compounds; Animals; Cell Death; Deoxyguanosine; Disease Models, Animal; Dizocilpine Maleate; In Situ Nick-End Labeling; Mice; N-Methylaspartate; Neurons; Neuroprotective Agents; Ocular Hypertension; Piperazines; Retina; Retinal Diseases; Time Factors | 2011 |
Edaravone-loaded liposomes for retinal protection against oxidative stress-induced retinal damage.
Topics: Animals; Antipyrine; Cell Line; Drug Compounding; Drug Delivery Systems; Edaravone; Excitatory Amino Acid Agonists; Eye; Free Radical Scavengers; Intravitreal Injections; Liposomes; Male; Mice; Molecular Targeted Therapy; N-Methylaspartate; Oxidative Stress; Phospholipids; Protective Agents; Retina; Retinal Diseases | 2011 |
Effect of inner retinal dysfunction on slow double-stimulation multifocal electroretinogram.
Topics: Adaptation, Physiological; Adult; Animals; Case-Control Studies; Disease Models, Animal; Early Diagnosis; Electroretinography; Gerbillinae; Glaucoma, Open-Angle; Humans; Middle Aged; N-Methylaspartate; Photic Stimulation; Retina; Retinal Diseases; Tetrodotoxin; Visual Fields | 2011 |
Involvement of endoplasmic reticulum stress in optic nerve degeneration following N-methyl-D-aspartate-induced retinal damage in mice.
Topics: Animals; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Excitatory Amino Acid Agonists; Fluorescent Antibody Technique; Heat-Shock Proteins; Male; Membrane Proteins; Mice; N-Methylaspartate; Nerve Degeneration; Nerve Tissue Proteins; Neurofilament Proteins; Optic Nerve Diseases; Real-Time Polymerase Chain Reaction; Retinal Diseases; Stress, Physiological; Transcription Factor CHOP | 2012 |
Protective effects of the β3-adrenoceptor agonist CL316243 against N-methyl-D-aspartate-induced retinal neurotoxicity.
Topics: Adrenergic beta-3 Receptor Agonists; Aminophenols; Animals; Dioxoles; Disease Models, Animal; Intravitreal Injections; Male; N-Methylaspartate; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Retinal Diseases; Retinal Ganglion Cells; Sulfonamides; Time Factors | 2012 |
Effect of nafamostat on N-methyl-D-aspartate-induced retinal neuronal and capillary degeneration in rats.
Topics: Animals; Basement Membrane; Benzamidines; Capillaries; Diabetic Neuropathies; Excitatory Amino Acid Agonists; Glaucoma; Glutamic Acid; Guanidines; Intravitreal Injections; Male; N-Methylaspartate; Nerve Degeneration; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Retina; Retinal Diseases; Retinal Ganglion Cells; Retinal Neurons; Retinal Vessels; Serine Proteinase Inhibitors; Severity of Illness Index; Vascular Diseases | 2012 |
Neuroprotective effects of olanzapine in N-methyl-D-aspartate-induced retinal injury.
Topics: Animals; Antipsychotic Agents; Benzodiazepines; Disease Models, Animal; Dose-Response Relationship, Drug; Ischemia; Male; Malondialdehyde; N-Methylaspartate; Neuroprotective Agents; Olanzapine; Rats; Rats, Wistar; Retina; Retinal Diseases; Retinal Ganglion Cells; Retinal Neurons | 2013 |
Protective effects of TGF-β inhibitors in a rat model of NMDA-induced retinal degeneration.
Topics: Animals; Benzamides; Capillaries; Dioxoles; Disease Models, Animal; Intravitreal Injections; Male; N-Methylaspartate; Pyrazoles; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Transforming Growth Factor beta; Retinal Diseases; Retinal Ganglion Cells; Retinal Vessels; Transforming Growth Factor beta | 2013 |
Alpha-lipoic acid protects the retina against ischemia-reperfusion.
Topics: Anesthetics, Local; Animals; Antioxidants; Binding, Competitive; Brain-Derived Neurotrophic Factor; Calcium; Calcium Channel Blockers; Cells, Cultured; Ciliary Neurotrophic Factor; Diltiazem; Dizocilpine Maleate; DNA Primers; Dose-Response Relationship, Drug; Drug Interactions; Electroretinography; Fibroblast Growth Factors; Glial Fibrillary Acidic Protein; Glyceraldehyde-3-Phosphate Dehydrogenases; N-Methylaspartate; Nifedipine; Rats; Reperfusion Injury; Retinal Diseases; Reverse Transcriptase Polymerase Chain Reaction; Rhodopsin; RNA, Messenger; Sodium; Tetrodotoxin; Thioctic Acid; Thy-1 Antigens; Veratridine | 2002 |
Neuroprotective effects of interleukin-6 on NMDA-induced rat retinal damage.
Topics: Animals; Blotting, Western; Contactins; Disease Models, Animal; In Situ Nick-End Labeling; Interleukin-6; Male; N-Methylaspartate; Neural Cell Adhesion Molecules; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Receptors, Interleukin-6; Retinal Diseases | 2003 |
The novel neuroprotective action of sulfasalazine through blockade of NMDA receptors.
Topics: Animals; Antioxidants; Calcium; Cells, Cultured; Cerebral Cortex; Cyclooxygenase 2; Disease Models, Animal; Ischemia; Isoenzymes; Male; Mice; Mice, Inbred ICR; N-Methylaspartate; Neuroprotective Agents; NF-kappa B; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Retinal Diseases; Sulfasalazine | 2003 |
Calcium antagonists in N-methyl d-aspartate-induced retinal injury.
Topics: Animals; Calcium Channel Blockers; Cell Count; Dantrolene; Drug Therapy, Combination; Excitatory Amino Acid Agonists; Guinea Pigs; Ischemia; Male; Malondialdehyde; N-Methylaspartate; Nimodipine; Retina; Retinal Diseases; Retinal Ganglion Cells; Retinal Vessels | 2003 |
Endogenous tissue type plasminogen activator facilitates NMDA-induced retinal damage.
Topics: Animals; Cell Count; DNA Fragmentation; Excitatory Amino Acid Agonists; Glutamates; In Situ Nick-End Labeling; Injections; Kainic Acid; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Neurons; Plasminogen Inactivators; Recombinant Proteins; Reperfusion Injury; Retina; Retinal Diseases; Retinal Ganglion Cells | 2004 |
Understanding neurochemical changes during retinal diseases.
Topics: Animals; Betaxolol; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Humans; N-Methylaspartate; Neurons; Retina; Retinal Diseases | 2004 |
Nuclear factor-kappa B p65 in NMDA-induced retinal neurotoxicity.
Topics: Animals; Cell Death; Excitatory Amino Acid Agonists; Male; Microinjections; N-Methylaspartate; Neuroprotective Agents; NF-kappa B; Oligodeoxyribonucleotides, Antisense; Rats; Rats, Wistar; Retina; Retinal Diseases; Transcription Factor RelA | 2004 |
BMP4 and CNTF are neuroprotective and suppress damage-induced proliferation of Müller glia in the retina.
Topics: Animals; Bone Morphogenetic Protein 4; Bone Morphogenetic Protein 7; Bone Morphogenetic Proteins; Cell Death; Cell Proliferation; Chick Embryo; Cicatrix; Ciliary Neurotrophic Factor; Gliosis; N-Methylaspartate; Nerve Degeneration; Nerve Growth Factors; Neuroglia; Neuroprotective Agents; Neurotoxins; Retina; Retinal Diseases; Transforming Growth Factor beta | 2004 |
Adeno-associated viruses containing bFGF or BDNF are neuroprotective against excitotoxicity.
Topics: Animals; Apoptosis; Brain-Derived Neurotrophic Factor; Cell Survival; Cytoprotection; Dependovirus; Excitatory Amino Acid Agonists; Fibroblast Growth Factor 2; Gene Expression Regulation; Genetic Therapy; Genetic Vectors; Green Fluorescent Proteins; N-Methylaspartate; Nerve Crush; Neuroprotective Agents; Optic Nerve; Rats; Rats, Sprague-Dawley; Retinal Diseases; Retinal Ganglion Cells; Transfection | 2004 |
Effects of poly(ADP-ribose) polymerase inhibitor on NMDA-induced retinal injury.
Topics: Animals; Benzamides; Cell Count; Cytoprotection; Dizocilpine Maleate; Dose-Response Relationship, Drug; Electroretinography; Enzyme Activation; Enzyme Inhibitors; Evoked Potentials, Visual; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Immunoenzyme Techniques; Injections; N-Methylaspartate; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Rabbits; Retina; Retinal Diseases; Retinal Ganglion Cells; Vitreous Body | 2004 |
Calpain and N-methyl-d-aspartate (NMDA)-induced excitotoxicity in rat retinas.
Topics: Animals; Apoptosis; Blotting, Western; Calpain; DNA Fragmentation; Immunohistochemistry; In Situ Nick-End Labeling; Isoenzymes; Male; N-Methylaspartate; Neurons; Neurotoxins; Rats; Rats, Sprague-Dawley; Retina; Retinal Diseases | 2005 |
Neuroprotective effects of minocycline against in vitro and in vivo retinal ganglion cell damage.
Topics: Animals; Benzimidazoles; Benzoxazoles; Cell Count; Cell Death; Cell Line; Culture Media, Serum-Free; Dose-Response Relationship, Drug; Drug Interactions; Endoplasmic Reticulum; Excitatory Amino Acid Agonists; Fluorescent Dyes; Male; Mice; Minocycline; N-Methylaspartate; Neuroprotective Agents; Propidium; Quinolinium Compounds; Rats; Reactive Oxygen Species; Retina; Retinal Diseases; Retinal Ganglion Cells; Tunicamycin | 2005 |
Preferential differentiation of neural progenitor cells into the glial lineage through gp130 signaling in N-methyl-D-aspartate-treated retinas.
Topics: Animals; Cell Count; Cell Differentiation; Cells, Cultured; Ciliary Neurotrophic Factor; Cytokine Receptor gp130; Embryo, Mammalian; Glial Fibrillary Acidic Protein; Glutamate-Ammonia Ligase; Green Fluorescent Proteins; Immunohistochemistry; Intermediate Filament Proteins; Male; Mice; Mice, Transgenic; Microtubule-Associated Proteins; N-Methylaspartate; Nerve Tissue Proteins; Nestin; Neuroglia; Neurons; Rats; Rats, Sprague-Dawley; Retinal Diseases; Rhodopsin; Signal Transduction; Statistics, Nonparametric; Stem Cell Transplantation; Stem Cells; Time Factors; Tubulin | 2005 |
NMDA-induced retinal injury is mediated by an endoplasmic reticulum stress-related protein, CHOP/GADD153.
Topics: Animals; Blotting, Western; Cell Death; Endoplasmic Reticulum; Excitatory Amino Acid Agonists; Heat-Shock Proteins; Immunohistochemistry; In Situ Nick-End Labeling; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Retinal Diseases; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transcription Factor CHOP | 2006 |
Thioredoxin inhibits NMDA-induced neurotoxicity in the rat retina.
Topics: Animals; Apoptosis; Blotting, Western; Caspase 3; Caspase 8; Caspase 9; Caspases; Excitatory Amino Acid Agonists; Immunoenzyme Techniques; Immunohistochemistry; In Situ Nick-End Labeling; Lipid Peroxidation; Male; Mitogen-Activated Protein Kinases; N-Methylaspartate; Neuroprotective Agents; Phosphorylation; Proto-Oncogene Proteins c-jun; Rats; Rats, Wistar; Retina; Retinal Diseases; Retinal Ganglion Cells; Thioredoxins; Tyrosine | 2006 |
Contribution of endogenous glycine site NMDA agonists to excitotoxic retinal damage in vivo.
Topics: Amidohydrolases; Animals; Cell Death; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Kynurenic Acid; Male; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Retinal Diseases; Retinal Ganglion Cells; Serine | 2006 |
Metallothionein, an endogenous antioxidant, protects against retinal neuron damage in mice.
Topics: Animals; Antioxidants; Buthionine Sulfoximine; Cell Culture Techniques; Cell Survival; Cholecalciferol; Glutamic Acid; Immunoenzyme Techniques; Injections; Male; Metallothionein; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Oxidative Stress; Retinal Diseases; Retinal Ganglion Cells; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Up-Regulation; Vitreous Body; Zinc Sulfate | 2006 |
[Experimental techniques for animal models of retinal diseases in mice].
Topics: Animals; Disease Models, Animal; Histological Techniques; Intraocular Pressure; Mice; N-Methylaspartate; Retina; Retinal Diseases | 2007 |
ERK1 plays a critical protective role against N-methyl-D-aspartate-induced retinal injury.
Topics: Animals; Cell Death; Disease Models, Animal; Enzyme Activation; Enzyme-Linked Immunosorbent Assay; Excitatory Amino Acid Agonists; Gene Expression Regulation; Glutamate-Ammonia Ligase; In Situ Nick-End Labeling; Male; Mice; Mice, Knockout; Mitogen-Activated Protein Kinase 3; N-Methylaspartate; Neuroglia; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Retinal Diseases; Signal Transduction; Time Factors | 2008 |
Expression of osteopontin in the rat retina: effects of excitotoxic and ischemic injuries.
Topics: Animals; Excitatory Amino Acid Agonists; Fluorescent Antibody Technique, Indirect; Immunoenzyme Techniques; Kainic Acid; N-Methylaspartate; Osteopontin; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Retina; Retinal Diseases; Retinal Ganglion Cells; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thy-1 Antigens; Transcription Factor Brn-3 | 2008 |
Degenerative alterations in the visual pathway after NMDA-induced retinal damage in mice.
Topics: Animals; Astrocytes; Brain-Derived Neurotrophic Factor; Functional Laterality; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Male; Mice; Mice, Inbred C57BL; N-Methylaspartate; Nerve Degeneration; Neurons; Phosphopyruvate Hydratase; Retinal Diseases; Time Factors; Visual Pathways | 2008 |
STAT3 activation protects retinal ganglion cell layer neurons in response to stress.
Topics: Adenoviridae; Animals; Cell Survival; Cells, Cultured; Cytoprotection; Disease Models, Animal; Excitatory Amino Acid Agonists; Glutamic Acid; Mice; Mice, Inbred Strains; N-Methylaspartate; Rats; Rats, Long-Evans; Reperfusion Injury; Retinal Diseases; Retinal Ganglion Cells; Retinal Vessels; STAT3 Transcription Factor; Stress, Physiological | 2008 |
A novel NMDA receptor antagonist protects against N-methyl-D-aspartate- and glutamate-induced neurotoxicity in the goldfish retina.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Drug Interactions; Glutamic Acid; Goldfish; Hippocampus; N-Methylaspartate; Neurons; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Retina; Retinal Diseases | 1997 |
Topically applied betaxolol attenuates NMDA-induced toxicity to ganglion cells and the effects of ischaemia to the retina.
Topics: Administration, Topical; Adrenergic beta-Antagonists; Animals; Betaxolol; Calcium Channel Blockers; Choline O-Acetyltransferase; Electroretinography; Ganglia, Sensory; N-Methylaspartate; Neuroprotective Agents; Rabbits; Rats; Rats, Wistar; Reperfusion Injury; Retina; Retinal Diseases | 1999 |
Induction of a 55-kDa PKN cleavage product by ischemia/reperfusion model in the rat retina.
Topics: Animals; Apoptosis; Caspase 3; Caspase Inhibitors; Disease Models, Animal; Fluorescent Antibody Technique, Indirect; Immunoblotting; Male; Molecular Weight; N-Methylaspartate; Oligopeptides; Protein Kinase C; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Rats; Rats, Wistar; Reperfusion Injury; Retinal Diseases | 2000 |
Retinal damage after 3 to 4 months of elevated intraocular pressure in a rat glaucoma model.
Topics: Animals; Cell Death; Cell Nucleus; Disease Models, Animal; DNA Fragmentation; Electroretinography; Female; Fluorescent Dyes; Glaucoma, Open-Angle; Intraocular Pressure; Membrane Potentials; Microscopy, Confocal; Microscopy, Fluorescence; Mitochondria; N-Methylaspartate; Rats; Rats, Wistar; Retinal Diseases; Retinal Ganglion Cells; Stilbamidines; Time Factors | 2000 |