n-methylaspartate has been researched along with Retinal Degeneration in 52 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (3.85) | 18.2507 |
| 2000's | 15 (28.85) | 29.6817 |
| 2010's | 32 (61.54) | 24.3611 |
| 2020's | 3 (5.77) | 2.80 |
| Authors | Studies |
|---|---|
| Cheng, L; Hou, C; Xiao, L; Yan, N; Zhao, L; Zheng, S | 1 |
| Furiya, M; Harashima, M; Hashizume, T; Hayashi, H; Mise, K; Mori, M; Mukaigaito, C; Takagi, N; Takemura, E; Yamada, M; Yuan, B | 1 |
| Asano, D; Kojima, M; Morita, A; Nakahara, T | 1 |
| Hu, T; Liu, Y; Sheibani, N; Smith, JA; Sorenson, CM; Tan, JW; Wang, S; Zhang, HF | 1 |
| Guo, X; Harada, C; Harada, T; Honda, S; Kimura, A; Matsuda, A; Murakami, A; Namekata, K | 1 |
| Deng, Q; Jiang, M; Li, Y; Ma, X; Shen, Y; Xing, Y; Zhao, Q | 1 |
| Casson, R; Chidlow, G; Sia, PI; Wood, JPM | 1 |
| Dick, HB; Grotegut, P; Joachim, SC; Kuehn, S; Meißner, W; Reinehr, S; Rodust, C; Stute, G | 1 |
| Cashman, SM; Dasari, B; Kumar, B; Kumar-Singh, R; Talreja, D | 1 |
| Han, YY; Liu, ZZ; Lu, Y; Mei, F; Sheng, W; Wang, HT; Wang, N; Xu, H; Zhang, X; Zou, S | 1 |
| Ahmadieh, H; Daftarian, N; Mowla, SJ; Naseri, M; Ranaei Pirmardan, E; Samiei, S; Soheili, ZS | 1 |
| Asano, D; Ishii, K; Mori, A; Morita, A; Nakahara, T; Sakamoto, K | 1 |
| Aksan, B; Fioravanti, R; Mai, A; Mauceri, D; Schlüter, A; Valente, S | 1 |
| Hara, H; Makita, S; Ohno, Y; Shimazawa, M; Tsuruma, K; Yasuno, Y | 1 |
| Harada, T; Kurosaka, D; Machida, S; Nishimura, T | 1 |
| Cosma, MP; Di Vicino, U; Fernández, E; Romo, N; Sanges, D; Simonte, G; Tahoces, AD | 1 |
| Guo, X; Harada, C; Harada, T; Kawamura, K; Kimura, A; Namekata, K; Tanaka, K | 1 |
| Akanuma, K; Ishii, K; Mori, A; Nakahara, T; Sakamoto, K; Ueda, K | 1 |
| Ishii, K; Kurauchi, Y; Mori, A; Nakahara, T; Sakamoto, K; Suzuki, Y | 1 |
| Asami, Y; Asano, D; Ishii, K; Kurauchi, Y; Mori, A; Nakahara, T; Sakamoto, K | 1 |
| Asano, D; Ishii, K; Mori, A; Nakahara, T; Sakamoto, K | 1 |
| Hanada, M; Ishii, K; Mori, A; Nakahara, T; Sakamoto, K | 1 |
| Choragiewicz, TJ; Gasior, M; Rejdak, R; Schuettauf, F; Thaler, S; Zarnowska, I; Zarnowski, T; Zrenner, E | 1 |
| Ambrósio, AF; Cordeiro, MF; Elvas, F; Galvao, J; Martins, T; Santiago, AR | 1 |
| Cuenca, N; de la Villa, P; Esquiva, G; Fernández-Sánchez, L; Germain, F; Gómez-Vicente, V; Lax, P; Rondón, N | 1 |
| Becker, S; Brown, RA; Charteris, DG; Eastlake, K; Jayaram, H; Jones, MF; Khaw, PT; Limb, GA; McLellan, GJ | 1 |
| Bollinger, KE; Fields, T; Gonsalvez, GB; Kim, L; Mysona, BA; Qureshi, A; Smith, SB; Zhao, J | 1 |
| Anand, A; Banik, A; Jindal, N; Prabhakar, S; Vaiphie, K | 1 |
| Casson, RJ; Chidlow, G; Manavis, J; Sarvestani, G; Wood, JP | 1 |
| Ishii, K; Kawakami, T; Kuwagata, M; Nakahara, T; Saito, M; Sakamoto, K; Shimada, M; Yamaguchi, A | 1 |
| Ishii, K; Ishii, T; Kuroki, T; Mori, A; Nakahara, T; Sakamoto, K; Shigeta, N | 1 |
| Boudard, DL; Hicks, D; Mendoza, J | 1 |
| Hara, H; Inokuchi, Y; Matsunaga, N; Nakajima, Y; Oka, T; Shimazawa, M; Suemori, S; Yamamoto, T | 1 |
| Hoshino, M; Ishii, K; Mori, A; Nakahara, T; Sakamoto, K; Ueda, K | 1 |
| Kondo, M; Kurosaka, D; Machida, S; Nishimura, T; Terasaki, H; Yokoyama, D | 1 |
| Broadway, DC; Niyadurupola, N; Osborne, A; Sanderson, J; Sidaway, P | 1 |
| Cotter, TG; Doonan, F; Messeguer, A; O'Driscoll, C; Sanvicens, N | 1 |
| Fujino, H; Kitaoka, Y; Kuribayashi, J; Munemasa, Y; Takada, K | 1 |
| Chen, F; Jiang, L; Jonas, JB; Shen, C; Wan, H; Wang, N; Xu, L | 1 |
| Abe, T; Ishiguro, S; Kano, T; Sakata, T; Tamai, M; Tomita, H | 1 |
| Kocki, T; Rejdak, R; Schuettauf, F; Turski, WA; Zagorski, Z; Zarnowski, T; Zrenner, E | 1 |
| Casson, RJ; Chidlow, G; Osborne, NN; Vidal-Sanz, M; Wood, JP | 1 |
| Isenoumi, K; Kitaoka, Y; Kobayashi, S; Kumai, T; Kuribayashi, K; Lam, TT; Motoki, M; Munemasa, Y; Ueno, S | 1 |
| Barkis, WB; Barres, BA; Chen, S; Diamond, JS; Ullian, EM | 1 |
| Araie, M; Fukaya, Y; Kashwagi, K; Ohashi, M; Saito, S; Suzuki, Y; Tomidokoro, A | 1 |
| Hayashi, Y; Isenoumi, K; Kitaoka, Y; Kobayashi, S; Kogo, J; Kumai, T; Kuribayashi, K; Motoki, M; Munemasa, Y; Ueno, S | 1 |
| Bush, RA; Fariss, RN; Machida, S; Raz-Prag, D; Sieving, PA | 1 |
| Tso, MO; Wang, W; Xu, YS; Zhang, C | 1 |
| Sabel, BA; Sautter, J; Siliprandi, R; Stoehr, T | 1 |
| Dreyer, EB; Kreutz, MR; Sabel, BA; Vorwerk, CK | 1 |
| Kwong, JM; Lam, TT | 1 |
| Bähr, M; Kermer, P; Klöcker, N | 1 |
52 other study(ies) available for n-methylaspartate and Retinal Degeneration
| Article | Year |
|---|---|
DZNep protects against retinal ganglion cell death in an NMDA-induced mouse model of retinal degeneration.
Topics: Adenosine; Animals; Cell Count; Cell Death; Disease Models, Animal; Electroretinography; Intravitreal Injections; Male; Mice; N-Methylaspartate; Retinal Degeneration; Retinal Ganglion Cells | 2021 |
Apolipoprotein E-Containing Lipoproteins and LRP1 Protect From NMDA-Induced Excitotoxicity Associated With Reducing α2-Macroglobulin in Müller Glia.
Topics: Animals; Apolipoproteins E; Cells, Cultured; Disease Models, Animal; Ependymoglial Cells; Female; Gene Expression Regulation; Low Density Lipoprotein Receptor-Related Protein-1; Male; Mice; Mice, Inbred C57BL; N-Methylaspartate; Neuroprotective Agents; Pregnancy-Associated alpha 2-Macroglobulins; Rats; Rats, Sprague-Dawley; Retinal Degeneration; Retinal Ganglion Cells; RNA | 2021 |
Tumor necrosis factor-α and matrix metalloproteinase-9 cooperatively exacerbate neurovascular degeneration in the neonatal rat retina.
Topics: Animals; Animals, Newborn; Matrix Metalloproteinase 9; N-Methylaspartate; Rats; Retina; Retinal Degeneration; Tumor Necrosis Factor Inhibitors; Tumor Necrosis Factor-alpha | 2022 |
Tunicamycin-induced photoreceptor atrophy precedes degeneration of retinal capillaries with minimal effects on retinal ganglion and pigment epithelium cells.
Topics: Animals; Anti-Bacterial Agents; Atrophy; Capillaries; Endoplasmic Reticulum Stress; Female; Fluorescent Antibody Technique, Indirect; In Situ Nick-End Labeling; Intravitreal Injections; Male; Mice; Mice, Inbred C57BL; N-Methylaspartate; Oxidative Stress; Photoreceptor Cells, Vertebrate; Retinal Degeneration; Retinal Ganglion Cells; Retinal Pigment Epithelium; Retinal Vessels; Tunicamycin; Zonula Occludens-1 Protein | 2019 |
Survival of Alpha and Intrinsically Photosensitive Retinal Ganglion Cells in NMDA-Induced Neurotoxicity and a Mouse Model of Normal Tension Glaucoma.
Topics: Adaptor Proteins, Vesicular Transport; Animals; Cell Survival; Disease Models, Animal; Excitatory Amino Acid Agonists; Fluorescent Antibody Technique, Indirect; Intravitreal Injections; Light; Low Tension Glaucoma; Mice; Mice, Inbred C57BL; Mice, Knockout; Microscopy, Fluorescence; N-Methylaspartate; Optic Disk; Osteopontin; Retinal Degeneration; Retinal Ganglion Cells; RNA-Binding Proteins | 2019 |
The neuroprotective effects of novel estrogen receptor GPER1 in mouse retinal ganglion cell degeneration.
Topics: Animals; Apoptosis; Blotting, Western; Disease Models, Animal; Gene Expression Regulation; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; N-Methylaspartate; Receptors, Estrogen; Receptors, G-Protein-Coupled; Retinal Degeneration; Retinal Ganglion Cells; RNA; Selective Estrogen Receptor Modulators; Tamoxifen | 2019 |
Creatine is Neuroprotective to Retinal Neurons In Vitro But Not In Vivo.
Topics: Animals; Blotting, Western; Cell Survival; Cells, Cultured; Creatine; Creatine Kinase; Electroretinography; Immunohistochemistry; In Situ Nick-End Labeling; Isoenzymes; N-Methylaspartate; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Retina; Retinal Degeneration; Retinal Ganglion Cells; Sodium Azide; Stress, Physiological | 2019 |
Concentration-Dependent Inner Retina Layer Damage and Optic Nerve Degeneration in a NMDA Model.
Topics: Animals; Apoptosis; Dose-Response Relationship, Drug; Male; Microglia; Myelin Sheath; N-Methylaspartate; Optic Nerve Diseases; Rats; Rats, Wistar; Retinal Degeneration; Retinal Neurons | 2017 |
G-quartet oligonucleotide mediated delivery of functional X-linked inhibitor of apoptosis protein into retinal cells following intravitreal injection.
Topics: Animals; Apoptosis; Aptamers, Nucleotide; Caspase 3; Caspase 7; Caspase Inhibitors; Cell Line; Drug Delivery Systems; Electrophoresis, Polyacrylamide Gel; Excitatory Amino Acid Agonists; G-Quadruplexes; Green Fluorescent Proteins; In Situ Nick-End Labeling; Intravitreal Injections; Mice; Mice, Inbred BALB C; Microscopy, Confocal; N-Methylaspartate; Oligodeoxyribonucleotides; Retina; Retinal Degeneration; X-Linked Inhibitor of Apoptosis Protein | 2018 |
Effect of Resveratrol on Sirtuins, OPA1, and Fis1 Expression in Adult Zebrafish Retina.
Topics: Animals; Antioxidants; Blotting, Western; DNA Damage; Female; Gene Expression Regulation; GTP Phosphohydrolases; Liver; Male; Mitochondria; Mitochondrial Proteins; N-Methylaspartate; Real-Time Polymerase Chain Reaction; Resveratrol; Retina; Retinal Degeneration; RNA, Messenger; Sirtuins; Zebrafish; Zebrafish Proteins | 2018 |
In Vivo Evaluation of PAX6 Overexpression and NMDA Cytotoxicity to Stimulate Proliferation in the Mouse Retina.
Topics: Animals; Cell Cycle; Cell Death; Cell Differentiation; Cell Line; Cell Proliferation; HEK293 Cells; Humans; Ki-67 Antigen; Mice; Models, Animal; N-Methylaspartate; PAX6 Transcription Factor; Retina; Retinal Degeneration; Retinal Ganglion Cells | 2018 |
Involvement of matrix metalloproteinases in capillary degeneration following NMDA-induced neurotoxicity in the neonatal rat retina.
Topics: Animals; Animals, Newborn; Blotting, Western; Capillaries; Disease Models, Animal; Matrix Metalloproteinase 9; N-Methylaspartate; Rats, Sprague-Dawley; Retinal Degeneration; Retinal Ganglion Cells; Retinal Vessels | 2019 |
Histone Deacetylases Contribute to Excitotoxicity-Triggered Degeneration of Retinal Ganglion Cells In Vivo.
Topics: Animals; Excitatory Amino Acid Agonists; Female; Histone Deacetylase Inhibitors; Histone Deacetylases; Intravitreal Injections; Male; Mice; Mice, Inbred C57BL; N-Methylaspartate; Retinal Degeneration; Retinal Ganglion Cells | 2019 |
Thickness mapping of the inner retina by spectral-domain optical coherence tomography in an N-methyl-D-aspartate-induced retinal damage model.
Topics: Animals; Cell Size; Excitatory Amino Acid Agonists; Male; Mice; N-Methylaspartate; Optic Disk; Retina; Retinal Degeneration; Retinal Ganglion Cells; Tomography, Optical Coherence | 2013 |
Contribution of N-methyl-DL-aspartic acid (NMDA)-sensitive neurons to generating oscillatory potentials in Royal College of Surgeons rats.
Topics: Animals; Dark Adaptation; Disease Models, Animal; Electroretinography; Intravitreal Injections; N-Methylaspartate; Oscillometry; Photic Stimulation; Photoreceptor Cells, Vertebrate; Rats; Rats, Mutant Strains; Retinal Degeneration; Retinal Neurons | 2013 |
Wnt/β-catenin signaling triggers neuron reprogramming and regeneration in the mouse retina.
Topics: Animals; beta Catenin; Cell Differentiation; Cell Fusion; Mice; N-Methylaspartate; Neurons; Regeneration; Retina; Retinal Degeneration; Stem Cells; Transcriptome; Wnt Proteins; Wnt Signaling Pathway | 2013 |
Dock3 attenuates neural cell death due to NMDA neurotoxicity and oxidative stress in a mouse model of normal tension glaucoma.
Topics: Animals; Apoptosis; Binding Sites; Carrier Proteins; Cell Line; Disease Models, Animal; Excitatory Amino Acid Transporter 1; Glutamic Acid; Guanine Nucleotide Exchange Factors; HEK293 Cells; Humans; Low Tension Glaucoma; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Oxidative Stress; Phosphorylation; Protein Binding; Receptors, N-Methyl-D-Aspartate; Retina; Retinal Degeneration; Retinal Ganglion Cells; Signal Transduction | 2013 |
Differential effects of LY294002 and wortmannin on neurons and vascular endothelial cells in the rat retina.
Topics: Androstadienes; Animals; Cell Count; Chromones; Endothelial Cells; Intravitreal Injections; Male; Morpholines; N-Methylaspartate; Protein Kinase Inhibitors; Rats; Retinal Degeneration; Retinal Ganglion Cells; Wortmannin | 2013 |
Hydrogen sulfide attenuates NMDA-induced neuronal injury via its anti-oxidative activity in the rat retina.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Aldehydes; Animals; Antioxidants; Apoptosis; Cell Survival; Deoxyguanosine; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Hydrogen Sulfide; In Situ Nick-End Labeling; Injections, Intraperitoneal; Intravitreal Injections; Male; N-Methylaspartate; Nitric Oxide Donors; Oxidative Stress; Rats; Rats, Sprague-Dawley; Retinal Degeneration; Retinal Ganglion Cells; Sulfides | 2014 |
Age-dependent changes in the severity of capillary degeneration in rat retina following N-methyl-D-aspartate-induced neurotoxicity.
Topics: Animals; Capillaries; Cell Death; Disease Models, Animal; Male; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Retinal Degeneration; Retinal Ganglion Cells; Severity of Illness Index | 2015 |
Regression of retinal capillaries following N-methyl-D-aspartate-induced neurotoxicity in the neonatal rat retina.
Topics: Age Factors; Animals; Animals, Newborn; Capillaries; Collagen Type IV; Disease Models, Animal; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Gene Expression Regulation, Developmental; Male; N-Methylaspartate; Neurotoxicity Syndromes; Phenylurea Compounds; Plant Lectins; Quinazolines; Rats; Rats, Sprague-Dawley; Rec A Recombinases; Retinal Degeneration; Statistics, Nonparametric; Vascular Endothelial Growth Factor A | 2015 |
Impaired retinal vasodilator response to acetylcholine in a rat model of NMDA-induced retinal degeneration.
Topics: Acetylcholine; Adrenergic beta-3 Receptor Agonists; Animals; Dioxoles; Disease Models, Animal; Endothelial Cells; Male; N-Methylaspartate; Rats, Wistar; Receptors, Adrenergic, beta-3; Retinal Artery; Retinal Degeneration; Vasodilation | 2015 |
Ketogenic diet attenuates NMDA-induced damage to rat's retinal ganglion cells in an age-dependent manner.
Topics: Animals; Cell Count; D-Aspartic Acid; Diet Therapy; Diet, Ketogenic; Disease Models, Animal; Female; N-Methylaspartate; Neuroprotective Agents; Rats; Rats, Inbred BN; Retinal Degeneration; Retinal Ganglion Cells | 2015 |
Adenosine A3 receptor activation is neuroprotective against retinal neurodegeneration.
Topics: Adenosine; Adenosine A3 Receptor Agonists; Adenosine A3 Receptor Antagonists; Animals; Animals, Newborn; Apoptosis; Cell Survival; Disease Models, Animal; Excitatory Amino Acid Agonists; Fluorescent Antibody Technique, Indirect; In Situ Nick-End Labeling; Intravitreal Injections; Male; N-Methylaspartate; Neuroprotection; Optic Nerve Injuries; Organ Culture Techniques; Rats; Rats, Wistar; Receptor, Adenosine A3; Retina; Retinal Degeneration; Retinal Neurons | 2015 |
Neuroprotective Effect of Tauroursodeoxycholic Acid on N-Methyl-D-Aspartate-Induced Retinal Ganglion Cell Degeneration.
Topics: Animals; Electroretinography; N-Methylaspartate; Neuroprotective Agents; Optic Nerve; Rats; Rats, Sprague-Dawley; Retina; Retinal Degeneration; Retinal Ganglion Cells; Taurochenodeoxycholic Acid | 2015 |
Allogeneic Transplantation of Müller-Derived Retinal Ganglion Cells Improves Retinal Function in a Feline Model of Ganglion Cell Depletion.
Topics: Animals; Cats; Cell Adhesion; Collagen; Disease Models, Animal; Electroretinography; Ependymoglial Cells; Humans; N-Methylaspartate; Neuroprotection; Primary Cell Culture; Retinal Degeneration; Retinal Ganglion Cells; Stem Cell Transplantation; Stem Cells; Tissue Scaffolds; Transplantation, Heterologous; Transplantation, Homologous; Vitrectomy; Vitreous Body | 2016 |
(+)-Pentazocine Reduces NMDA-Induced Murine Retinal Ganglion Cell Death Through a σR1-Dependent Mechanism.
Topics: Animals; Apoptosis; Blotting, Western; Cell Count; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; In Situ Nick-End Labeling; Injections, Intraperitoneal; Intravitreal Injections; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; N-Methylaspartate; Narcotic Antagonists; Pentazocine; Receptors, sigma; Retinal Degeneration; Retinal Ganglion Cells; Sigma-1 Receptor | 2016 |
Alteration of Neurotrophic Factors After Transplantation of Bone Marrow Derived Lin-ve Stem Cell in NMDA-Induced Mouse Model of Retinal Degeneration.
Topics: Animals; Bone Marrow Cells; Brain-Derived Neurotrophic Factor; Ciliary Neurotrophic Factor; Disease Models, Animal; Female; Glial Cell Line-Derived Neurotrophic Factor; Homeodomain Proteins; Male; Mice; Mice, Inbred C57BL; N-Methylaspartate; Nerve Growth Factors; Retina; Retinal Degeneration; Retinal Ganglion Cells; Stem Cell Transplantation; Stem Cells; Transcription Factor Brn-3B | 2017 |
Evaluation of Fluoro-Jade C as a marker of degenerating neurons in the rat retina and optic nerve.
Topics: Animals; Biomarkers; Excitatory Amino Acid Agonists; Fluoresceins; Fluorescent Dyes; N-Methylaspartate; Optic Nerve; Rats; Rats, Sprague-Dawley; Retinal Degeneration; Retinal Ganglion Cells; Reverse Transcriptase Polymerase Chain Reaction | 2009 |
Histological protection by cilnidipine, a dual L/N-type Ca(2+) channel blocker, against neurotoxicity induced by ischemia-reperfusion in rat retina.
Topics: Amlodipine; Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, N-Type; Dihydropyridines; Drug Evaluation, Preclinical; In Situ Nick-End Labeling; Injections; Injections, Intravenous; Male; N-Methylaspartate; Neuroprotective Agents; Nitroso Compounds; omega-Conotoxins; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Retinal Degeneration; Retinal Diseases; Vitreous Body | 2009 |
The prostanoid EP(2) receptor agonist ONO-AE1-259-01 protects against glutamate-induced neurotoxicity in rat retina.
Topics: Animals; Cell Count; Dinoprostone; Glutamic Acid; Injections; Male; N-Methylaspartate; Neurotoxins; Rats; Rats, Sprague-Dawley; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP2 Subtype; Retina; Retinal Degeneration; Retinal Ganglion Cells | 2009 |
Loss of photic entrainment at low illuminances in rats with acute photoreceptor degeneration.
Topics: Animals; Circadian Rhythm; Disease Models, Animal; Gene Expression Regulation; Light; Light Signal Transduction; Lighting; Male; N-Methylaspartate; Opsins; Photic Stimulation; Photoreceptor Cells, Vertebrate; Rats; Rats, Long-Evans; Retinal Degeneration; Rhodopsin; Rod Opsins | 2009 |
A novel calpain inhibitor, ((1S)-1-((((1S)-1-Benzyl-3-cyclopropylamino-2,3-di-oxopropyl)amino)carbonyl)-3-methylbutyl)carbamic acid 5-methoxy-3-oxapentyl ester (SNJ-1945), reduces murine retinal cell death in vitro and in vivo.
Topics: Administration, Oral; Animals; Calpain; Carbamates; Cell Line; Cell Survival; Glycoproteins; Injections, Intraperitoneal; Male; Mice; Mice, Inbred Strains; N-Methylaspartate; Retina; Retinal Degeneration; Retinal Ganglion Cells | 2010 |
Retinal blood vessels are damaged in a rat model of NMDA-induced retinal degeneration.
Topics: Animals; Basement Membrane; Endothelial Cells; Endothelium, Vascular; Male; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Retina; Retinal Degeneration; Retinal Ganglion Cells; Retinal Vessels | 2010 |
Pharmacological dissection of multifocal electroretinograms of rabbits with Pro347Leu rhodopsin mutation.
Topics: Aminobutyrates; Animals; Animals, Genetically Modified; Electroretinography; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; N-Methylaspartate; Photoreceptor Cells, Vertebrate; Pipecolic Acids; Point Mutation; Rabbits; Retinal Bipolar Cells; Retinal Degeneration; Rhodopsin; Sodium Channel Blockers; Synapses; Tetrodotoxin | 2010 |
The development of human organotypic retinal cultures (HORCs) to study retinal neurodegeneration.
Topics: Apoptosis; Cell Hypoxia; Cells, Cultured; Glaucoma; Humans; Immunohistochemistry; N-Methylaspartate; Nerve Degeneration; Retinal Degeneration; Retinal Ganglion Cells; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thy-1 Antigens; Tissue Culture Techniques; Visual Pathways | 2011 |
A novel free radical scavenger rescues retinal cells in vivo.
Topics: Animals; Apoptosis; Benzopyrans; Blotting, Western; Cell Count; Disease Models, Animal; Electrophoresis, Polyacrylamide Gel; Female; Free Radical Scavengers; In Situ Nick-End Labeling; Injections, Intraperitoneal; Intravitreal Injections; Light; Male; Malondialdehyde; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; N-Methylaspartate; Photoreceptor Cells, Vertebrate; Radiation Injuries, Experimental; Reactive Oxygen Species; Retina; Retinal Degeneration; Retinal Ganglion Cells; Superoxides | 2011 |
Protective effect of thalidomide against N-methyl-D-aspartate-induced retinal neurotoxicity.
Topics: Animals; Drug Interactions; In Situ Nick-End Labeling; Male; N-Methylaspartate; Neuroprotective Agents; Neurotoxins; Rats; Rats, Wistar; Retinal Degeneration; Retinal Ganglion Cells; Thalidomide; Tumor Necrosis Factor-alpha | 2011 |
Neuroprotective effect of epigallocatechin-3-gallate against N-methyl-D-aspartate-induced excitotoxicity in the adult rat retina.
Topics: Animals; Apoptosis; Catechin; Cell Count; Cell Survival; Excitatory Amino Acid Agonists; Female; Injections, Intraperitoneal; N-Methylaspartate; Neuroprotective Agents; Rats; Rats, Wistar; Retinal Degeneration; Retinal Ganglion Cells; RNA, Messenger; Thy-1 Antigens | 2012 |
Protective effect against ischemia and light damage of iris pigment epithelial cells transfected with the BDNF gene.
Topics: Animals; Brain-Derived Neurotrophic Factor; Cell Survival; Coculture Techniques; Cytoprotection; Enzyme-Linked Immunosorbent Assay; Immunoenzyme Techniques; Iris; Ischemia; Light; Male; N-Methylaspartate; Photoreceptor Cells, Vertebrate; Pigment Epithelium of Eye; Radiation Injuries, Experimental; Rats; Rats, Long-Evans; Rats, Sprague-Dawley; Rats, Wistar; Retinal Degeneration; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transfection | 2002 |
Alterations of kynurenic acid content in the retina in response to retinal ganglion cell damage.
Topics: Animals; Cell Death; Chromatography, High Pressure Liquid; Kynurenic Acid; Male; N-Methylaspartate; Rats; Rats, Inbred BN; Retina; Retinal Degeneration; Retinal Ganglion Cells | 2003 |
The effect of retinal ganglion cell injury on light-induced photoreceptor degeneration.
Topics: Animals; Axotomy; Ciliary Neurotrophic Factor; Electroretinography; Eye Proteins; Female; Fibroblast Growth Factor 2; G-Protein-Coupled Receptor Kinase 1; Glial Fibrillary Acidic Protein; Light; N-Methylaspartate; Optic Nerve; Photoreceptor Cells, Vertebrate; Protein Kinases; Radiation Injuries, Experimental; Rats; Rats, Wistar; Retinal Degeneration; Retinal Ganglion Cells; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Rod Opsins; Up-Regulation | 2004 |
Involvement of RhoA and possible neuroprotective effect of fasudil, a Rho kinase inhibitor, in NMDA-induced neurotoxicity in the rat retina.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Count; Disease Models, Animal; Drug Interactions; Enzyme Inhibitors; Glutamic Acid; Intracellular Signaling Peptides and Proteins; Male; N-Methylaspartate; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Protein Serine-Threonine Kinases; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Retina; Retinal Degeneration; Retinal Ganglion Cells; rho-Associated Kinases; rhoA GTP-Binding Protein; RNA, Messenger; Thy-1 Antigens; Up-Regulation | 2004 |
Invulnerability of retinal ganglion cells to NMDA excitotoxicity.
Topics: Amacrine Cells; Animals; Animals, Newborn; Cell Death; Cells, Cultured; Dose-Response Relationship, Drug; Drug Resistance; Fluorescent Dyes; Glutamic Acid; Hippocampus; N-Methylaspartate; Neurotoxins; Rats; Receptors, N-Methyl-D-Aspartate; Retinal Degeneration; Retinal Ganglion Cells; Stilbamidines; Synaptic Transmission | 2004 |
Ocular distribution after topical instillation and potential neuroprotective effect after intravitreal injection of the calcium channel blocker iganipidine.
Topics: Administration, Topical; Animals; Calcium Channel Blockers; Cell Count; Choroid; Gas Chromatography-Mass Spectrometry; Injections; Kainic Acid; Male; N-Methylaspartate; Neuroprotective Agents; Piperazines; Pyridines; Rats; Rats, Wistar; Retina; Retinal Degeneration; Retinal Ganglion Cells; Tissue Distribution; Vitreous Body | 2005 |
Neuroprotective effect of atrial natriuretic peptide against NMDA-induced neurotoxicity in the rat retina.
Topics: Analysis of Variance; Animals; Antibodies; Atrial Natriuretic Factor; Benzazepines; Blotting, Western; Chromatography, High Pressure Liquid; Disease Models, Animal; Domperidone; Dopamine; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Electrochemistry; Excitatory Amino Acid Agonists; Immunohistochemistry; Intracellular Space; Male; N-Methylaspartate; Neuroprotective Agents; Neurotoxicity Syndromes; PC12 Cells; Rats; Rats, Wistar; Retinal Degeneration; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tyrosine 3-Monooxygenase | 2006 |
Photopic ERG negative response from amacrine cell signaling in RCS rat retinal degeneration.
Topics: Amacrine Cells; Animals; Animals, Genetically Modified; Cell Count; Dopamine; Electroretinography; gamma-Aminobutyric Acid; Light; Microscopy, Confocal; N-Methylaspartate; Potassium Channels, Inwardly Rectifying; Rats; Rats, Long-Evans; Rats, Mutant Strains; Rats, Sprague-Dawley; Retina; Retinal Degeneration; Retinal Ganglion Cells; Rhodopsin; Signal Transduction | 2008 |
[Pathological study of retinal excitotoxicity following subretinal injection of NMDA].
Topics: Animals; N-Methylaspartate; Rabbits; Retina; Retinal Degeneration | 2007 |
A behavioral model of excitotoxicity: retinal degeneration, loss of vision, and subsequent recovery after intraocular NMDA administration in adult rats.
Topics: Animals; Behavior, Animal; Cell Survival; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Eye; Horseradish Peroxidase; Injections; N-Methylaspartate; Orientation; Rats; Rats, Inbred Strains; Retinal Degeneration; Retinal Ganglion Cells; Vision Disorders; Visual Fields | 1995 |
Systemic L-kynurenine administration partially protects against NMDA, but not kainate-induced degeneration of retinal ganglion cells, and reduces visual discrimination deficits in adults rats.
Topics: Animals; Behavior, Animal; Biological Transport; Cell Count; Cell Death; Excitatory Amino Acid Agonists; Horseradish Peroxidase; Image Processing, Computer-Assisted; Kainic Acid; Kynurenine; Light; N-Methylaspartate; Rats; Retinal Degeneration; Retinal Ganglion Cells; Vision Disorders; Visual Perception | 1996 |
N -methyl- D -aspartate (NMDA) induced apoptosis in adult rabbit retinas.
Topics: Animals; Apoptosis; Caspase Inhibitors; Caspases; Dizocilpine Maleate; In Situ Nick-End Labeling; Microscopy, Electron; N-Methylaspartate; Neuroprotective Agents; Rabbits; Retina; Retinal Degeneration | 2000 |
Modulation of metabotropic glutamate receptors fails to prevent the loss of adult rat retinal ganglion cells following axotomy or N-methyl-D-aspartate lesion in vivo.
Topics: Animals; Axotomy; Cell Count; Denervation; Evoked Potentials, Visual; Excitatory Amino Acid Agonists; Eye; Female; Injections; N-Methylaspartate; Optic Nerve; Rats; Rats, Inbred Strains; Receptors, Metabotropic Glutamate; Retinal Degeneration; Retinal Ganglion Cells; Vision, Ocular | 2001 |