n-methylaspartate has been researched along with Nerve Degeneration in 229 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (4.80) | 18.7374 |
| 1990's | 85 (37.12) | 18.2507 |
| 2000's | 99 (43.23) | 29.6817 |
| 2010's | 33 (14.41) | 24.3611 |
| 2020's | 1 (0.44) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, S; Luo, X; Nawy, S; Shen, Y | 1 |
| Burtscher, J; Di Pardo, A; Maglione, V; Millet, GP; Schwarzer, C; Zangrandi, L | 1 |
| Borsello, T; Cimini, S; Garção, P; Giorgini, F; Hassanjani, M; Lilley, KS; Maddison, DC; Outeiro, TF; Panman, L; Patel, B; Repici, M; Straatman, KR; Szegö, ÉM | 1 |
| Eto, K; Kashiwagi, K; Koizumi, S; Nabekura, J; Ohno, N; Shinozaki, Y; Takeda, A; Wake, H | 1 |
| Bading, H; Bengtson, CP; Hardingham, GE; McKay, S; Wyllie, DJ | 1 |
| Akyol, E; Brothwell, SL; Gibb, AJ; Jones, S; Kimkool, P; Skepper, JN; Wild, AR | 1 |
| Luo, J; Pepperberg, DR; Qin, Z; Tavassoli, E; Thatcher, GR; Vandevrede, L; Yue, L | 1 |
| Ayalon, G; Bustos, D; Gogineni, A; Hanson, JE; Jubb, AM; Kirkpatrick, DS; Larson, JL; Lee, SH; Lewcock, JW; Li, H; Ngu, H; Pozniak, CD; Scearce-Levie, K; Sengupta Ghosh, A; Solanoy, H; Weimer, RM; Wu, J; Zhou, Q | 1 |
| Alberch, J; Ceña, V; Collon, KW; Domercq, M; Fernández-Díez, B; Franco, R; Giralt, A; Giralt, E; Gottlieb, M; Lopez, I; Martínez-Pinilla, E; Matute, C; Moreno, B; Parent, JM; Posadas, I; Sánchez-Gómez, MV; Teixido, M; Villoslada, P; Zhang, H | 1 |
| Cheng, J; Gu, Z; Liu, W; Qin, L; Yan, Z; Zhong, P | 1 |
| Hayashi, T; Hirano, T; Murata, T | 1 |
| Andrade, C; Batlle, M; Ferri, L; Mahy, N; Ortega, FJ; Pugliese, M; Rodríguez, MJ; Vidal-Taboada, JM | 1 |
| Hanig, JP; Liu, F; Patterson, TA; Paule, MG; Rainosek, SW; Sadovova, N; Slikker, W; Wang, C | 1 |
| Fritschy, JM; Jirak, D; Kleteckova, L; Kubesova, A; Rambousek, L; Vales, K | 1 |
| Andrés, RM; Barneda-Zahonero, B; Coccia, E; Comella, JX; Gasull, X; Martínez-Mármol, R; Moubarak, RS; Planells-Ferrer, L; Soriano, E; Soto, D | 1 |
| Dekens, D; Dong, Y; Douwenga, W; Duffey, M; Eisel, UL; Fischer, R; Guenzi, E; Herrmann, A; Kontermann, RE; Maier, O; Naudé, PJ; Nyakas, C; Pfizenmaier, K; Van der Zee, EA | 1 |
| Dehghani, F; Ghadban, C; Hailer, NP; Korf, HW; Vogt, C | 1 |
| Curini, M; Epifano, F; Genovese, S; Molinaro, G; Ngomba, RT; Nicoletti, F | 1 |
| Granic, I; Gross, G; Luiten, P; Möller, A; Nimmrich, V; Nyakas, C; Reymann, KG; Schoemaker, H; Schröder, UH; Szabo, R; Wicke, K | 1 |
| Cheng, ZJ; Gozal, D; Harden, SW; Li, L; Lin, Y; Wead, WB; Wurster, RD; Yan, B | 1 |
| Al-Sarraf, H; Krajci, D; Mohammadi, S; Pavlik, A | 1 |
| Kawada, K; Kuramoto, N; Nagashima, R; Ogita, K; Seko, K; Shuto, M; Sugiyama, C; Yoneyama, M | 1 |
| André, VM; Deng, Y; Figueroa, BE; Friedlander, R; Graham, RK; Hayden, MR; Joshi, P; Leavitt, BR; Levine, MS; Lu, G; Metzler, M; Pouladi, MA; Raymond, L; Slow, EJ; Wu, NP | 1 |
| Hara, H; Ito, Y; Nakamura, S; Shimazawa, M; Tanaka, H | 1 |
| Brunet, N; Calderó, J; Esquerda, JE; Tarabal, O | 1 |
| Araie, M; Hara, H; Ito, Y; Nakamura, S; Shimazawa, M; Tanaka, H; Tsuruma, K | 1 |
| Berry, JN; Butler, TR; Littleton, JM; Mulholland, PJ; Pauly, JR; Prendergast, MA; Self, RL; Sharrett-Field, LJ; Smith, KJ | 1 |
| Cross, AH; Goldberg, MP; Gonzales, E; Pitt, D | 1 |
| Aronowski, J; Grotta, JC; Palusinski, R; Piriyawat, P; Strong, R; Zhao, X | 1 |
| Hayes, RL; Kobeissy, FH; Larner, SF; Liu, MC; Sadasivan, S; Wang, KK; Zhang, Z; Zheng, W | 1 |
| Izumi, Y; Zorumski, CF | 1 |
| Finn, R; Kovács, AD; Pearce, DA | 1 |
| Dehghani, F; Ebrahimi, F; Ghadban, C; Hezel, M; Koch, M; Korf, HW | 1 |
| Blumbergs, PC; Casson, RJ; Chotaliya, HP; Saggu, SK | 1 |
| Belousov, AB; Denisova, JV; Fontes, JD; Kang, KS; Wang, Y; Zhu, BT | 1 |
| Broadway, DC; Niyadurupola, N; Osborne, A; Sanderson, J; Sidaway, P | 1 |
| Hayes, RL; Kobeissy, F; Liu, MC; Wang, KK; Zhang, Z; Zheng, W | 1 |
| Biber, K; Boddeke, HW; Brouwer, N; Heinrich, A; Heppner, FL; Kälin, RE; Rooijen, Nv; Vinet, J; Weering, HR; Wegner, A | 1 |
| Abrahám, IM; Kőszegi, Z | 1 |
| Aihara, M; Hara, H; Ito, Y; Miwa, A; Shimazawa, M; Tsuruma, K | 1 |
| Jeng, W; Wells, PG | 1 |
| Berry, JN; Butler, TR; Prendergast, MA; Sharrett-Field, LJ | 1 |
| Ishii, K; Mori, A; Nakahara, T; Sakamoto, K; Tsuda, Y; Ueda, K | 1 |
| Lisý, V; Stastný, F | 1 |
| Ali, C; Buisson, A; Carmeliet, P; Docagne, F; Fernández-Monreal, M; Gabriel, C; Lesné, S; MacKenzie, ET; Nicole, O; Plawinski, L; Vivien, D | 1 |
| Belmadani, A; Collins, MA; Neafsey, EJ | 1 |
| Aruoma, OI; Gentleman, SM; Higa, T; Jen, LS; Ke, B; Liang, YF; Moncaster, JA; Walsh, DT | 1 |
| Bown, CD; Wang, JF; Young, LT | 1 |
| Hao, HP; Hashioka, S; Miyamoto, K; Murao, K; Nakanishi, H; Saido, TC; Zhang, J | 1 |
| Gruol, DL; Qiu, Z | 1 |
| Farkas, T; Högyes, E; Kiliaan, A; Luiten, PG; Nyakas, C; Penke, B | 1 |
| Ahmed, Z; Baker, D; Croxford, JL; Cuzner, ML; Giovannoni, G; Hankey, DJ; Jackson, SJ; Ledent, C; Petzold, A; Pocock, JM; Pryce, G; Thompson, AJ | 1 |
| Kim, H; Kim, SY; Kim, YS; Lee, J; Lee, P; Son, D | 1 |
| Halaris, A; Piletz, JE; Regunathan, S; Zhu, MY | 1 |
| Gilliams-Francis, KL; Naegele, JR; Quaye, AA | 1 |
| Dikranian, K; Farber, NB; Jiang, X; Nemmers, B | 1 |
| Akaike, A; Katsuki, H | 1 |
| Hewett, JA; Hewett, SJ; Silakova, JM | 2 |
| Benarese, M; Boroni, F; Dreano, M; Garotta, G; Pizzi, M; Sarnico, I; Spano, P; Valerio, A | 1 |
| Caccamo, D; Crisafulli, G; Currò, M; Cusumano, G; Ientile, R | 1 |
| Arundine, M; Tymianski, M | 1 |
| Isenoumi, K; Kitaoka, Y; Kobayashi, S; Kumai, T; Kuribayashi, K; Lam, TT; Motoki, M; Munemasa, Y; Ueno, S | 1 |
| Harkany, T; Horvath, KM; Koolhaas, JM; Luiten, PG; Meerlo, P; Mulder, J | 1 |
| Chad, JE; McManus, T; Pringle, AK; Sadgrove, M; Sundstrom, LE | 1 |
| Iravani, MM; Jenner, P; Liu, L; Rose, S | 1 |
| Fischer, AJ; Omar, G; Reh, TA; Schmidt, M | 1 |
| Akopian, G; Andersen, JK; Boonplueang, R; Kuhlenkamp, JF; Lu, SC; Stevenson, FF; Walsh, JP | 1 |
| Abulrob, A; Brunette, E; Faid, K; Mealing, G; Stanimirovic, D; Tauskela, JS | 1 |
| Humpel, C; Moser, KV | 1 |
| Ampo, K; Kadono, C; Kiryu-Seo, S; Kiyama, H; Konishi, H; Maeda, M; Ohba, N | 1 |
| Ajmone-Cat, MA; Berardi, M; Fedele, E; Greco, A; Levi, G; Minghetti, L; Pepicelli, O; Raiteri, M | 1 |
| Cremers, TI; Czollner, K; Harkany, T; Keijser, JN; Luiten, PG; Mulder, J; Nyakas, C | 1 |
| Kress, GJ; Reynolds, IJ | 1 |
| Boriboun, C; Marks, JD; Wang, J | 1 |
| André, VM; Cepeda, C; Chandler, SH; de Lima, M; Levine, MS; Starling, AJ | 1 |
| Annunziato, L; Boscia, F; Taglialatela, M | 1 |
| Bertram, L; Bissada, N; Deng, Y; Doty, CN; Graham, RK; Haigh, B; Hayden, MR; Leavitt, BR; Lu, G; Murphy, Z; Nicholson, DW; Pearson, J; Raymond, LA; Roy, S; Shehadeh, J; Slow, EJ; Warby, SC; Wellington, CL | 1 |
| Duncan, RS; Gregg, EV; Koulen, P; Singh, M; Xin, H; Yannazzo, JA | 1 |
| Dehghani, F; Ghadban, C; Koch, M; Korf, HW; Kreutz, S | 1 |
| Aurelian, L; Golembewski, EK; Wales, SQ; Yarowsky, PJ | 1 |
| Acarin, L; Campuzano, O; Castellano, B; Castillo-Ruiz, MM; Gonzalez, B | 1 |
| Doi, Y; Kawanokuchi, J; Kuno, R; Liang, J; Mizuno, T; Suzumura, A; Takeuchi, H; Yawata, I; Zang, G | 1 |
| Chen, Z; Dai, H; Fan, Y; Fu, Q; Hu, W; Shen, Y | 1 |
| Calderó, J; Casanovas, A; Casas, C; Ciutat, D; Esquerda, JE; Lladó, J; Tarabal, O | 1 |
| Bonde, C; Jensen, CV; Jensen, NA; Montero, M; Nielsen, JV; Noraberg, J; Zimmer, J | 1 |
| Borsello, T; Clarke, PG; Puyal, J; Vaslin, A | 1 |
| Acarin, L; Castellano, B; Faiz, M; González, B; Rohn, TT; Villapol, S | 1 |
| Li, C; Xu, J; Zhang, GY; Zhang, QG | 1 |
| Guidetti, P; Poeggeler, B; Rassoulpour, A; Roberts, RC; Schwarcz, R; Wu, HQ | 1 |
| Acarin, L; Arís, A; Castellano, B; González, B; González, P; Peluffo, H; Saura, J; Villaverde, A | 1 |
| Aurelian, L; Golembewski, EK; Jafri, MS; Laing, JM; Liu, J; Wales, SQ; Yarowsky, PJ | 1 |
| Barsoum, MJ; Bossy-Wetzel, E; Lipton, SA; Malhotra, V; Nakagomi, S; Sütterlin, C | 1 |
| Aono, S; Hayakawa, M; Ida, M; Kakizawa, H; Kojima, S; Kuroda, Y; Maeda, H; Matsui, F; Nakanishi, K; Oohira, A; Saito, A; Sato, Y; Tokita, Y | 1 |
| Baptiste, SL; Devinsky, O; Kuzniecky, RI; Ludvig, N; Sheffield, LG; Tang, HM | 1 |
| Baxter, MG; Crosby, G; Culley, DJ; Murphy, KL | 1 |
| Faraji, J; Lehmann, H; Metz, GA; Sutherland, RJ | 1 |
| Acarin, L; Castellano, B; Faiz, M; Gonzalez, B; Villapol, S | 1 |
| Lipton, P; Windelborn, JA | 1 |
| Acarin, L; Castellano, B; Faiz, M; Gonzalez, B; Schulz, S; Villapol, S | 1 |
| Araie, M; Fukumitsu, H; Furukawa, S; Hara, H; Inokuchi, Y; Ito, Y; Shimazawa, M | 1 |
| Kumar, U | 1 |
| Bussey, TJ; Dias, R; Saksida, LM; Talpos, JC | 1 |
| Kawasaki, K; Okada, M; Sakaguchi, T | 1 |
| Dohrman, DP; Goodlett, CR; Luo, J; Pantazis, NJ; Thomas, JD; West, JR | 1 |
| Anderton, BH; Leigh, PN; Meldrum, BS; Nunn, PB; Willis, CL | 1 |
| Massieu, L; Tapia, R | 1 |
| Albert, A; Bonhomme, V; Collette, J; Hans, P; Moonen, G | 1 |
| Garthwaite, G; Garthwaite, J | 3 |
| Rothwell, NJ; Strijbos, PJ | 1 |
| Lu, YM; Weiss, JH; Yin, HZ | 1 |
| Canzoniero, LM; Choi, DW; Csernansky, C; Demaro, J; Gwag, BJ; Koh, JY; Sensi, SL; Wie, MB | 1 |
| Bordner, J; Butler, TW; Chambers, LK; Chenard, BL; Collins, MA; De Costa, DL; Ducat, MF; Dumont, ML; Fox, CB; Mena, EE | 1 |
| Bjerkness, L; Choi, DW; Hartley, DM; Kurth, MC; Weiss, JH | 1 |
| Ellison, G | 1 |
| Choi, DW; Gwag, BJ; Koh, JY; Lobner, D | 1 |
| Battaglia, G; Bruno, V; Canonico, PL; Copani, A; Nicoletti, F; Sortino, MA | 1 |
| Desagher, S; Glowinski, J; Marin, P; Maus, M; Prémont, J | 1 |
| Akaike, N; Himori, N; Imai, M; Kurasawa, M; Matsukura, T; Mishima, K; Tanaka, Y; Ueno, K; Watanabe, H | 1 |
| Chatterjee, SS; Nöldner, M | 1 |
| Keilhoff, G; Wolf, G | 1 |
| Burg, M; Horowski, R; Kalveram, KT; Lange, KW; Löschmann, PA; Riederer, P; Sofic, E; Wachtel, H | 1 |
| Monard, D; Nitsch, C; Scotti, AL | 1 |
| Choi, DW; Koh, JY | 1 |
| Bagetta, G; Finazzi-Agrò, A; Nisticò, G; Palma, E | 1 |
| Cline, HT; Constantine-Paton, M; McDonald, JW | 1 |
| Duberley, RM; Ham, J; Rickards, CR; Scanlon, MF | 1 |
| Michaelis, EK | 1 |
| Lunn, WH; McDonald, JW; Salhoff, CR; Schoepp, DD | 1 |
| Jarrard, LE; Meldrum, BS | 1 |
| Chandler, LJ; Crews, FT; Sumners, C | 1 |
| Panter, SS; Regan, RF; Renn, KE | 1 |
| Battaglia, G; Bruno, V; Copani, A; Giffard, RG; Nicoletti, F; Raciti, G; Raffaele, R; Shinozaki, H | 1 |
| Bruno, V; Casabona, G; Condorelli, DF; Copani, A; Dell'Albani, P; Knöpfel, T; Kuhn, R; Nicoletti, F | 1 |
| Dawson, TM; Dawson, VL | 1 |
| Bernert, H; Turski, L | 1 |
| Calderó, J; Ciutat, D; Esquerda, JE; Oppenheim, RW | 1 |
| Acarin, L; Castellano, B; Castro, AJ; González, B | 2 |
| Capdevila, JL; Trullas, R; Viu, E; Zapata, A | 1 |
| Chiang, J; Lu, YM; Weiss, JH; Yin, HZ | 1 |
| Battaglia, G; Bruno, V; Condorelli, DF; Copani, A; Dell'Albani, P; Nicoletti, F | 1 |
| Prehn, JH | 1 |
| Bakker, R; Douma, BR; Luiten, PG; Nyakas, C; Stuiver, BT | 1 |
| Baronio, P; Consolo, S; Di Chiara, G; Guidi, G | 1 |
| Bonanno, L; Bruno, V; Copani, A; Knoepfel, T; Kuhn, R; Nicoletti, F; Roberts, PJ | 1 |
| Ikonomidou, C; Turski, L | 1 |
| Block, F; Schwarz, M | 1 |
| Kawasaki, K; Kuno, M; Okada, M; Sakaguchi, T | 1 |
| Abrahám, I; Bohus, BG; Harkany, T; Luiten, PG; Nyakas, C; Veenema, AH | 1 |
| Scallet, AC; Ye, X | 1 |
| Tapia, R | 1 |
| Baruzzi, F; Memo, M; Paterlini, M; Spano, PF; Valerio, A | 1 |
| McGaugh, JL; Roozendaal, B; Sapolsky, RM | 1 |
| Marsala, M; Vanický, I; Yaksh, TL | 1 |
| Bywood, PT; Johnson, SM | 2 |
| Dora, CD; Koch, S; Liu, S; Ruenes, G; Sanchez, A; Yezierski, RP | 1 |
| Battaglia, G; Bruno, V; Copani, A; Di Grezia, R; Ngomba, RT; Nicoletti, F | 1 |
| Bolton, SJ; Perry, VH | 1 |
| Beani, L; Bianchi, C; Fuxe, K; Marti, M; Morari, M; Sbrenna, S | 1 |
| Broersen, L; Feldon, J; Gubler, MK; Pouzet, B; Rawlins, JN; Veenman, CL; Welzl, H; Yee, BK | 1 |
| Bittigau, P; Hübner, C; Ikonomidou, C; Ishimaru, MJ; Olney, JW; Pohl, D; Stadthaus, D; Turski, L | 1 |
| Chia, LG; Hajnik, T; Kuo, JS; Lai, YY; Shalita, T; Siegel, JM; Wu, JP | 1 |
| Hicks, CA; Isaac, D; O'Neill, MJ; Osborne, DJ; Stamford, JA; Ward, MA | 1 |
| Chen, Q; Reiner, A; Surmeier, DJ | 1 |
| Iannotti, F; Pringle, AK; Signorelli, F; Thomas, SJ | 1 |
| Calderó, J; Esquerda, JE; Lladó, J; Oppenheim, RW; Ribera, J; Tarabal, O | 1 |
| Choi, I; Gwag, BJ; Huh, K; Jung, NP; Kim, EY; Ko, HW; Oh, YK; Park, EC; Shin, HC; Won, SJ | 1 |
| Battaglia, G; Bond, A; Bruno, V; Clark, BP; Harris, JR; Kingston, AE; Lodge, D; Monn, JA; Nicoletti, F; O'Neill, MJ; Schoepp, DD | 1 |
| Benarese, M; Boroni, F; Goffi, F; Pizzi, M; Spano, PF; Valerio, A | 1 |
| Hong, NS; McDonald, RJ | 1 |
| Borin, G; Ceccon, M; Facci, L; Floreani, M; Giusti, P; Imbesi, M; Skaper, SD | 1 |
| Chan, SL; Glazner, GW; Lu, C; Mattson, MP | 1 |
| Abrahám, I; Harkany, T; Horvath, KM; Luiten, PG; Nyakas, C; Penke, B; Veenema, AH | 1 |
| Cuzner, ML; Fox, RM; Griffin, GE; Hayes, GM | 1 |
| Battaglia, G; Bruno, V; Catania, MV; Flor, PJ; Gasparini, F; Giuffrida, R; Hampson, DR; Inderbitzin, W; Ksiazek, I; Kuhn, R; Leonhardt, T; Lukic, S; Nicoletti, F; van der Putten, H | 1 |
| Battaglia, G; Bruno, V; Flor, PJ; Gasparini, F; Ksiazek, I; Kuhn, R; Leonhardt, T; Lukic, S; Nicoletti, F; Sauer, D | 1 |
| Baille, V; Bockaert, J; Djebaïli, M; Rondouin, G | 1 |
| Acarin, L; Castellano, B; González, B | 1 |
| Abrahám, I; Dijkstra, IM; Harkany, T; Horvath, KM; Keijser, J; Luiten, PG; Oosterink, BJ; Van der Zee, EA | 1 |
| Brusa, R; Casarini, M; Diodato, E; Grilli, M; Lozza, G; Memo, M; Ongini, E; Rozmahel, R; St George-Hyslop, P; Uberti, D; Westaway, D | 1 |
| Honda, Y; Honjo, M; Inatani, M; Kido, N; Nakayama, C; Tanihara, H; Tatsuno, T | 1 |
| Erskine, MS; Polston, EK | 1 |
| Harris, BR; Hauser, KF; Holley, RC; Littleton, JM; Mayer, S; Prendergast, MA | 1 |
| Jeśko, H; Strosznajder, JB; Strosznajder, RP | 1 |
| de Gregorio-Rocasolano, N; Paul, SM; Petegnief, V; Saura, J | 1 |
| Battaglia, G; Bruno, V; Ceña, V; Cespédes, VM; Copani, A; Flor, PJ; Galindo, MF; Gasparini, F; Kuhn, R; Nicoletti, F; Sánchez-Prieto, J | 1 |
| Anthony, DC; Iannotti, F; Johns, P; Niyadurupola, N; Pringle, AK | 1 |
| Hara, H; Honda, Y; Honjo, M; Inatani, M; Kido, N; Miyawaki, N; Tanihara, H; Yoneda, S | 1 |
| Day, BJ; Li, QY; Patel, M; Pedersen, C | 1 |
| Dehghani, F; Hailer, NP; Hischebeth, GT; Korf, HW; Roser, N; Wirjatijasa, F | 1 |
| Cahill, L; McGaugh, JL; Vazdarjanova, A | 1 |
| Berrendero, F; Bittigau, P; Fernández-Ruiz, JJ; Hansen, HH; Hansen, HS; Ikonomidou, C; Lastres-Becker, I; Manzanares, J; Schmid, HH; Schmid, PC | 1 |
| Grosche, J; Harkany, T; Härtig, W; Hortobágyi, T; Horvath, KM; Keijser, J; Luiten, PG; Mulder, J | 1 |
| Diestel, A; Eyüpoglu, IY; Nitsch, R; Ullrich, O | 1 |
| Acarin, L; Castellano, B; González, B; Paris, J | 1 |
| Choi, YH; Jang, YP; Kim, J; Kim, SG; Kim, SR; Kim, YC; Markelonis, GJ; Oh, TH | 1 |
| Mao, J; Mayer, DJ | 1 |
| Aleppo, G; Aronica, E; Bruno, V; Canonico, PL; Copani, A; D'Agata, V; Nicoletti, F; Pisani, A | 1 |
| Avanzini, G; Bugiani, O; Franceschetti, S; Panzica, F | 1 |
| Fukamauchi, F; Shibuya, H; Yoshikawa, T | 1 |
| Isacson, O; Sofroniew, MV | 1 |
| Arnold, MB; Deeter, JB; Jones, ND; Leander, JD; Lodge, D; Ornstein, PL; Schoepp, DD | 1 |
| Hao, JX; Seiger, A; Sundström, E; Watson, BD; Wiesenfeld-Hallin, Z; Xu, XJ | 1 |
| Benz, AM; Clifford, DB; Izumi, Y; Zorumski, CF | 1 |
| Isokawa, M; Levesque, MF | 1 |
| Cotman, CW; Koh, JY; Lin, A; Palmer, E | 1 |
| Kollegger, H; McBean, GJ; Tipton, KF | 1 |
| Olney, JW; Pathikonda, M; Snider, WD; Stewart, GR | 1 |
| Arvin, B; Le Peillet, E; Meldrum, BS; Moncada, C | 1 |
| Leander, JD; Ornstein, PL; Salhoff, CR; Schoepp, DD | 1 |
| Himori, N; Martin, JR; Moreau, JL | 1 |
| Baimbridge, KG; Choi, DW; Koh, J; Weiss, JH | 1 |
| Dingledine, R; McNamara, D | 1 |
| Choi, DW; Hartley, DM; Monyer, H | 1 |
| Chung, SK; Cohen, RS; Pfaff, DW | 1 |
| Bernardi, G; Calabresi, P; De Murtas, M; Mercuri, NB | 1 |
| Hillman, CC; Ornstein, PL; Salhoff, CR; Schoepp, DD | 1 |
| Ikonomidou, C; Labruyere, J; Mosinger, JL; Olney, JW; Salles, KS | 1 |
| Finger, S; Olney, JW; Stewart, GR; Wozniak, DF | 1 |
| Meldrum, B; Schwarcz, R | 1 |
| Morgan, IG | 1 |
| Benavides, J; Carter, C; Fage, D; Scatton, B | 1 |
| Foster, AC; Gill, R; Woodruff, GN | 1 |
| Meldrum, B | 1 |
| Foster, AC; Gill, R; Kemp, JA; Woodruff, GN | 1 |
9 review(s) available for n-methylaspartate and Nerve Degeneration
| Article | Year |
|---|---|
A Rationale for Hypoxic and Chemical Conditioning in Huntington's Disease.
Topics: Brain; Cell Hypoxia; Humans; Huntington Disease; Mitochondria; N-Methylaspartate; Nerve Degeneration; Neuroprotective Agents; Oxidative Stress; Signal Transduction; Sphingosine | 2021 |
Molecular mechanisms of glutamate-dependent neurodegeneration in ischemia and traumatic brain injury.
Topics: Animals; Brain Injuries; Brain Ischemia; Glutamic Acid; Humans; N-Methylaspartate; Nerve Degeneration; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate | 2004 |
Two different families of NMDA receptors in mammalian brain: physiological function and role in neuronal development and degeneration.
Topics: Alternative Splicing; Animals; Brain; Cloning, Molecular; N-Methylaspartate; Nerve Degeneration; Neurons; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate | 1993 |
Nitric oxide in neuronal degeneration.
Topics: Animals; Humans; N-Methylaspartate; Nerve Degeneration; Nervous System; Nervous System Diseases; Neuroprotective Agents; Nitric Oxide; Nitric Oxide Synthase | 1996 |
Metabotropic glutamate receptors and neuronal degeneration in culture.
Topics: Animals; Cells, Cultured; Cerebral Cortex; N-Methylaspartate; Nerve Degeneration; Receptors, Metabotropic Glutamate | 1996 |
Neurodegenerative disorders: clues from glutamate and energy metabolism.
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Damage, Chronic; Brain Injuries; Brain Ischemia; Energy Metabolism; Excitatory Amino Acid Antagonists; Glutamates; Humans; N-Methylaspartate; Nerve Degeneration; Nervous System Diseases; Neurotoxins | 1996 |
Excitotoxic mechanisms of neurodegeneration in transmissible spongiform encephalopathies.
Topics: Animals; Brain; Cricetinae; Glutamic Acid; Humans; Hypothalamus; Ibogaine; Kainic Acid; Mice; N-Methylaspartate; Nerve Degeneration; Neurotoxins; Prion Diseases | 1997 |
Release and uptake of glutamate as related to excitotoxicity.
Topics: 4-Aminopyridine; Cell Culture Techniques; Glutamic Acid; N-Methylaspartate; Nerve Degeneration | 1996 |
Spinal cord neuroplasticity following repeated opioid exposure and its relation to pathological pain.
Topics: Analgesics; Analgesics, Opioid; Animals; Benzamides; Dizocilpine Maleate; Drug Tolerance; Hot Temperature; Humans; Hyperalgesia; Morphine; Multiple Chemical Sensitivity; N-Methylaspartate; Narcotics; Nerve Degeneration; Nerve Tissue Proteins; Neuralgia; Neuronal Plasticity; Nitric Oxide; Phosphorylation; Poly(ADP-ribose) Polymerases; Posterior Horn Cells; Protein Kinase C; Protein Processing, Post-Translational; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid; Receptors, Opioid, mu; Sciatic Nerve; Spinal Cord | 2001 |
220 other study(ies) available for n-methylaspartate and Nerve Degeneration
| Article | Year |
|---|---|
Rod bipolar cells dysfunction occurs before ganglion cells loss in excitotoxin-damaged mouse retina.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cell Cycle Proteins; Dendrites; Disease Models, Animal; Electroretinography; Glaucoma; HEK293 Cells; Humans; Male; Mice, Inbred C57BL; N-Methylaspartate; Nerve Degeneration; Neurotoxins; Phosphorylation; Proteasome Endopeptidase Complex; Protein Binding; Protein Kinase C-alpha; Proteolysis; Receptors, N-Methyl-D-Aspartate; Retinal Bipolar Cells; Retinal Cone Photoreceptor Cells; Retinal Ganglion Cells; Retinal Rod Photoreceptor Cells; Ubiquitin | 2019 |
The Parkinson's Disease-Linked Protein DJ-1 Associates with Cytoplasmic mRNP Granules During Stress and Neurodegeneration.
Topics: Animals; Cytoplasmic Granules; HEK293 Cells; Humans; Mice; N-Methylaspartate; Nerve Degeneration; Neurons; Osmotic Pressure; Oxidative Stress; Parkinson Disease; Protein Binding; Protein Deglycase DJ-1; Rats; Ribonucleoproteins; Stress, Physiological | 2019 |
Microglia mediate non-cell-autonomous cell death of retinal ganglion cells.
Topics: Aminopyridines; Animals; Animals, Newborn; Calcium-Binding Proteins; Cell Death; Cells, Cultured; Cytokines; Excitatory Amino Acid Agonists; Gene Expression Regulation; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microfilament Proteins; Microglia; N-Methylaspartate; Nerve Degeneration; Optic Nerve Injuries; Organic Chemicals; Pyrroles; Retinal Ganglion Cells; Signal Transduction; Transcription Factor Brn-3A; Tumor Necrosis Factor-alpha | 2018 |
Recovery of NMDA receptor currents from MK-801 blockade is accelerated by Mg2+ and memantine under conditions of agonist exposure.
Topics: Animals; Cations; Cells, Cultured; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Magnesium; Memantine; Membrane Potentials; N-Methylaspartate; Nerve Degeneration; Neurons; Rats; Receptors, N-Methyl-D-Aspartate; Time Factors | 2013 |
Memantine block depends on agonist presentation at the NMDA receptor in substantia nigra pars compacta dopamine neurones.
Topics: Animals; Cell Count; Dizocilpine Maleate; Dopaminergic Neurons; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Male; Memantine; N-Methylaspartate; Nerve Degeneration; Rats; Receptors, N-Methyl-D-Aspartate; Substantia Nigra; Tyrosine 3-Monooxygenase | 2013 |
Novel analogues of chlormethiazole are neuroprotective in four cellular models of neurodegeneration by a mechanism with variable dependence on GABA(A) receptor potentiation.
Topics: Animals; Biological Availability; Brain; Calcium; Cell Hypoxia; Chlormethiazole; Chromatography, High Pressure Liquid; Excitatory Amino Acid Agonists; Female; GABA Agonists; gamma-Aminobutyric Acid; Glucose; Glutamic Acid; Mice; Mice, Inbred C57BL; N-Methylaspartate; Nerve Degeneration; Neurons; Neuroprotective Agents; Oocytes; Pregnancy; Primary Cell Culture; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Xenopus laevis | 2014 |
Dual leucine zipper kinase is required for excitotoxicity-induced neuronal degeneration.
Topics: Animals; Brain; Disks Large Homolog 4 Protein; Glutamic Acid; Guanylate Kinases; Kainic Acid; MAP Kinase Kinase Kinases; MAP Kinase Signaling System; Membrane Proteins; Mice; Mice, Knockout; N-Methylaspartate; Nerve Degeneration; Nerve Tissue Proteins; Synapses | 2013 |
Differential neuroprotective effects of 5'-deoxy-5'-methylthioadenosine.
Topics: Acute Disease; Adrenergic Antagonists; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Blood-Brain Barrier; Brain Ischemia; Cell Membrane Permeability; Cells, Cultured; Chronic Disease; Deoxyadenosines; Disease Models, Animal; Glucose; Male; Mice; N-Methylaspartate; Nerve Degeneration; Neuroprotective Agents; Neurotoxins; Oxygen; Pilocarpine; Rats; Rats, Sprague-Dawley; Rats, Wistar; Status Epilepticus; Thionucleosides | 2014 |
Aβ selectively impairs mGluR7 modulation of NMDA signaling in basal forebrain cholinergic neurons: implication in Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Choline O-Acetyltransferase; N-Methylaspartate; Nerve Degeneration; Neurons; Parasympathetic Nervous System; Prosencephalon; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Signal Transduction | 2014 |
Physiological significance of recombination-activating gene 1 in neuronal death, especially optic neuropathy.
Topics: Animals; Apoptosis; Gene Knockdown Techniques; Genes, RAG-1; HEK293 Cells; Homeodomain Proteins; Humans; Mice; Mice, Inbred C57BL; Mice, Knockout; Models, Neurological; N-Methylaspartate; Nerve Degeneration; NF-kappa B p50 Subunit; Optic Nerve Diseases; Recombinant Proteins; Retinal Ganglion Cells; Signal Transduction; Transcription Factor Brn-3A | 2015 |
Astroglia-Microglia Cross Talk during Neurodegeneration in the Rat Hippocampus.
Topics: Animals; Astrocytes; beta-N-Acetylhexosaminidases; Cell Proliferation; Gene Expression; Hippocampus; Microglia; N-Methylaspartate; Nerve Degeneration; Neurons; Rats; Receptors, Glucocorticoid; S100 Calcium Binding Protein beta Subunit; Tumor Necrosis Factor-alpha | 2015 |
Ketamine-Induced Toxicity in Neurons Differentiated from Neural Stem Cells.
Topics: Animals; Apoptosis; Astrocytes; Calcium; Cell Division; Cells, Cultured; Cerebral Cortex; Culture Media; DNA Damage; Dose-Response Relationship, Drug; Extracellular Fluid; Glycine; Intercellular Signaling Peptides and Proteins; Ketamine; Mitochondria; N-Methylaspartate; Necrosis; Nerve Degeneration; Neural Stem Cells; Neurogenesis; Neurons; Oligodendroglia; Rats; Rats, Sprague-Dawley | 2015 |
Rat intra-hippocampal NMDA infusion induces cell-specific damage and changes in expression of NMDA and GABAA receptor subunits.
Topics: Animals; Disease Models, Animal; Functional Laterality; Hippocampus; Male; Maze Learning; N-Methylaspartate; Nerve Degeneration; Neurodegenerative Diseases; Neuroimmunomodulation; Neurons; Rats, Long-Evans; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate | 2016 |
FAIM-L regulation of XIAP degradation modulates Synaptic Long-Term Depression and Axon Degeneration.
Topics: Animals; Apoptosis Regulatory Proteins; Axons; Cells, Cultured; Ganglia, Spinal; Hippocampus; Inhibitor of Apoptosis Proteins; Long-Term Synaptic Depression; Mice; N-Methylaspartate; Nerve Degeneration; Neuronal Plasticity; Neurons; Protein Stability; Proteolysis; Receptors, AMPA; RNA, Small Interfering; Up-Regulation | 2016 |
Essential protective role of tumor necrosis factor receptor 2 in neurodegeneration.
Topics: Animals; Antibodies; Basal Nucleus of Meynert; Carrier Proteins; Cell Death; Cholinergic Neurons; HEK293 Cells; Humans; Inflammation; Mice; N-Methylaspartate; Nerve Degeneration; Receptors, Tumor Necrosis Factor, Type I; Receptors, Tumor Necrosis Factor, Type II; Tumor Necrosis Factor-alpha | 2016 |
Successful inhibition of excitotoxic neuronal damage and microglial activation after delayed application of interleukin-1 receptor antagonist.
Topics: Animals; Astrocytes; Hippocampus; Immunohistochemistry; Interleukin 1 Receptor Antagonist Protein; Interleukin-1beta; Microglia; Microscopy, Confocal; N-Methylaspartate; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Organ Culture Techniques; Rats; Rats, Wistar; Receptors, Interleukin-1; Time | 2008 |
Neuroprotective effect of prenyloxycoumarins from edible vegetables.
Topics: Animals; Astrocytes; Cells, Cultured; Coumarins; Excitatory Amino Acid Agonists; Mice; N-Methylaspartate; Nerve Degeneration; Neurons; Neuroprotective Agents; Vegetables | 2008 |
Inhibition of Calpain Prevents N-Methyl-D-aspartate-Induced Degeneration of the Nucleus Basalis and Associated Behavioral Dysfunction.
Topics: Animals; Basal Nucleus of Meynert; Benzamides; Calpain; Cognition; Dose-Response Relationship, Drug; Hippocampus; Long-Term Potentiation; Male; Microglia; Motor Activity; N-Methylaspartate; Nerve Degeneration; Neuroprotective Agents; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 2008 |
Chronic intermittent hypoxia impairs heart rate responses to AMPA and NMDA and induces loss of glutamate receptor neurons in nucleus ambiguous of F344 rats.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Baroreflex; Blood Pressure; Brain Stem; Disease Models, Animal; Down-Regulation; Excitatory Amino Acid Agonists; Heart; Heart Rate; Hypoxia; Microinjections; Motor Neurons; N-Methylaspartate; Nerve Degeneration; Rats; Rats, Inbred F344; Receptors, AMPA; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate | 2009 |
NMDA preconditioning and neuroprotection in vivo: delayed onset of kainic acid-induced neurodegeneration and c-Fos attenuation in CA3a neurons.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Cell Death; Dizocilpine Maleate; Female; Gene Expression; Genes, fos; Hippocampus; Kainic Acid; N-Methylaspartate; Nerve Degeneration; Neurons; Neuroprotective Agents; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate | 2009 |
Activation of c-Jun N-terminal kinase cascades is involved in part of the neuronal degeneration induced by trimethyltin in cortical neurons of mice.
Topics: Animals; Anthracenes; Cell Survival; Cells, Cultured; Cerebral Cortex; Dizocilpine Maleate; Enzyme Activation; Fungicides, Industrial; Immunoblotting; Injections, Intraperitoneal; JNK Mitogen-Activated Protein Kinases; Male; MAP Kinase Kinase 4; Mice; Mice, Inbred Strains; N-Methylaspartate; Nerve Degeneration; Neurons; Phosphorylation; Time Factors; Trimethyltin Compounds | 2009 |
Differential susceptibility to excitotoxic stress in YAC128 mouse models of Huntington disease between initiation and progression of disease.
Topics: Animals; Brain; Brain Ischemia; Cells, Cultured; Dendritic Spines; Disease Models, Animal; Disease Progression; Genetic Predisposition to Disease; Huntington Disease; Mice; Mice, Transgenic; N-Methylaspartate; Nerve Degeneration; Neurotoxins; Organ Culture Techniques; Phenotype; Quinolinic Acid; Stress, Physiological; Synaptic Membranes; Synaptic Potentials; Synaptic Transmission | 2009 |
Involvement of brain-derived neurotrophic factor in time-dependent neurodegeneration in the murine superior colliculus after intravitreal injection of N-methyl-D-aspartate.
Topics: Animals; Astrocytes; Brain-Derived Neurotrophic Factor; DNA-Binding Proteins; Drug Administration Routes; Fluorescent Antibody Technique; Glial Fibrillary Acidic Protein; Injections; Mice; Mice, Inbred C57BL; N-Methylaspartate; Nerve Degeneration; Nerve Tissue Proteins; Neurons; Nuclear Proteins; Retina; Superior Colliculi; Time Factors | 2009 |
Excitotoxic motoneuron degeneration induced by glutamate receptor agonists and mitochondrial toxins in organotypic cultures of chick embryo spinal cord.
Topics: Animals; Calcium Signaling; Chick Embryo; Disease Models, Animal; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Glutamic Acid; Kainic Acid; Malonates; Mitochondria; Motor Neuron Disease; Motor Neurons; N-Methylaspartate; Nerve Degeneration; Neuroprotective Agents; Neurotoxins; Nitro Compounds; Organ Culture Techniques; Propionates; Riluzole; Spinal Cord | 2009 |
Lomerizine, a Ca2+ channel blocker, protects against neuronal degeneration within the visual center of the brain after retinal damage in mice.
Topics: Animals; Calcium Channel Blockers; Disease Models, Animal; Geniculate Bodies; Male; Mice; Mice, Inbred C57BL; N-Methylaspartate; Nerve Degeneration; Phosphopyruvate Hydratase; Piperazines; Proto-Oncogene Proteins c-fos; Retinal Diseases; Retinal Ganglion Cells; Statistics, Nonparametric; Superior Colliculi; Time Factors; Visual Pathways | 2010 |
Selective vulnerability of hippocampal cornu ammonis 1 pyramidal cells to excitotoxic insult is associated with the expression of polyamine-sensitive N-methyl-D-asparate-type glutamate receptors.
Topics: Animals; CA1 Region, Hippocampal; CA3 Region, Hippocampal; Dentate Gyrus; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Female; Hippocampus; In Vitro Techniques; Male; N-Methylaspartate; Nerve Degeneration; Neuroprotective Agents; Neurotoxins; Piperidines; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spermidine; Valine | 2010 |
Dysmyelinated axons in shiverer mice are highly vulnerable to alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor-mediated toxicity.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Biomarkers; Brain; Disease Models, Animal; Excitatory Amino Acid Agonists; Female; Hereditary Central Nervous System Demyelinating Diseases; Luminescent Proteins; Mice; Mice, Inbred C57BL; Mice, Neurologic Mutants; Movement Disorders; Myelin Basic Protein; N-Methylaspartate; Nerve Degeneration; Nerve Fibers, Myelinated; Neurotoxins; Receptors, AMPA | 2010 |
Caffeinol at the receptor level: anti-ischemic effect of N-methyl-D-aspartate receptor blockade is potentiated by caffeine.
Topics: Animals; Brain Ischemia; Caffeine; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Combinations; Drug Synergism; Ethanol; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Guanidines; Male; N-Methylaspartate; Nerve Degeneration; Neuroprotective Agents; Neurotoxins; Phosphodiesterase Inhibitors; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Time Factors; Treatment Outcome | 2010 |
Acute NMDA toxicity in cultured rat cerebellar granule neurons is accompanied by autophagy induction and late onset autophagic cell death phenotype.
Topics: Adenine; Animals; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Caspase 3; Cell Death; Cells, Cultured; Central Nervous System Agents; Cerebellum; Lysosomes; N-Methylaspartate; Nerve Degeneration; Neurons; Neurotoxins; Phenotype; Rats; Rats, Sprague-Dawley; Signal Transduction; Time Factors | 2010 |
Neuroprotective effects of pyruvate following NMDA-mediated excitotoxic insults in hippocampal slices.
Topics: Adenosine Triphosphate; Aging; Animals; Brain Injuries; CA1 Region, Hippocampal; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glyceraldehyde-3-Phosphate Dehydrogenases; Hippocampus; In Vitro Techniques; N-Methylaspartate; Nerve Degeneration; Neurotoxins; Nitric Oxide; Pyruvic Acid; Rats; Receptors, N-Methyl-D-Aspartate; Synapses | 2010 |
Altered sensitivity to excitotoxic cell death and glutamate receptor expression between two commonly studied mouse strains.
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Cell Death; Cell Survival; Cells, Cultured; Cerebellar Cortex; Dose-Response Relationship, Drug; Drug Resistance; Excitatory Amino Acid Agonists; Male; Mice; Mice, Inbred C57BL; N-Methylaspartate; Nerve Degeneration; Neurotoxins; Organ Culture Techniques; Pyrimidinones; Receptors, Glutamate; Species Specificity | 2010 |
Analyses of neuronal damage in excitotoxically lesioned organotypic hippocampal slice cultures.
Topics: Animals; CA1 Region, Hippocampal; Coloring Agents; Dentate Gyrus; Excitatory Amino Acid Agonists; Microscopy, Confocal; Microscopy, Fluorescence; N-Methylaspartate; Nerve Degeneration; Neurons; Propidium; Rats; Rats, Wistar; Tissue Culture Techniques | 2010 |
Wallerian-like axonal degeneration in the optic nerve after excitotoxic retinal insult: an ultrastructural study.
Topics: Animals; Axons; Demyelinating Diseases; Endoplasmic Reticulum; Excitatory Amino Acid Agonists; Male; Microscopy, Electron, Transmission; Mitochondria; N-Methylaspartate; Nerve Degeneration; Optic Nerve; Rats; Rats, Sprague-Dawley; Retina; Retinal Ganglion Cells; Tissue Fixation; Wallerian Degeneration | 2010 |
Neuronal gap junctions are required for NMDA receptor-mediated excitotoxicity: implications in ischemic stroke.
Topics: Animals; Apoptosis; Blood-Brain Barrier; Brain Ischemia; Cells, Cultured; Connexins; Dentate Gyrus; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Gap Junction delta-2 Protein; Gap Junctions; Male; Mefloquine; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Nerve Degeneration; Neurons; Neurotoxins; Patch-Clamp Techniques; Photochemistry; Receptors, N-Methyl-D-Aspartate; Rose Bengal | 2010 |
The development of human organotypic retinal cultures (HORCs) to study retinal neurodegeneration.
Topics: Apoptosis; Cell Hypoxia; Cells, Cultured; Glaucoma; Humans; Immunohistochemistry; N-Methylaspartate; Nerve Degeneration; Retinal Degeneration; Retinal Ganglion Cells; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thy-1 Antigens; Tissue Culture Techniques; Visual Pathways | 2011 |
Dual vulnerability of tau to calpains and caspase-3 proteolysis under neurotoxic and neurodegenerative conditions.
Topics: Analysis of Variance; Animals; Animals, Newborn; Brain; Brain Injuries; Calpain; Caspase 3; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; Gene Expression Regulation; Male; Molecular Weight; N-Methylaspartate; Nerve Degeneration; Neurons; Neurotoxicity Syndromes; Neurotoxins; Peptide Hydrolases; Protein Isoforms; Rats; tau Proteins | 2011 |
Neuroprotective function for ramified microglia in hippocampal excitotoxicity.
Topics: Animals; CD11b Antigen; Cell Death; Clodronic Acid; Dose-Response Relationship, Drug; Glial Fibrillary Acidic Protein; Hippocampus; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microglia; N-Methylaspartate; Nerve Degeneration; Neurons; Neurotoxins; Organ Culture Techniques; Phosphopyruvate Hydratase | 2012 |
Effect of ageing on post-lesion oestradiol treatment on mouse cholinergic neurones in vivo.
Topics: Aging; Animals; Basal Nucleus of Meynert; Cell Death; Cholinergic Neurons; Disease Models, Animal; Estradiol; Estrous Cycle; Female; Male; Mice; Mice, Inbred C57BL; Microinjections; Molecular Imaging; N-Methylaspartate; Nerve Degeneration; Neural Pathways; Neuroprotective Agents; Somatosensory Cortex | 2012 |
Involvement of endoplasmic reticulum stress in optic nerve degeneration following N-methyl-D-aspartate-induced retinal damage in mice.
Topics: Animals; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Excitatory Amino Acid Agonists; Fluorescent Antibody Technique; Heat-Shock Proteins; Male; Membrane Proteins; Mice; N-Methylaspartate; Nerve Degeneration; Nerve Tissue Proteins; Neurofilament Proteins; Optic Nerve Diseases; Real-Time Polymerase Chain Reaction; Retinal Diseases; Stress, Physiological; Transcription Factor CHOP | 2012 |
Reduced 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy)-initiated oxidative DNA damage and neurodegeneration in prostaglandin H synthase-1 knockout mice.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Behavior, Animal; Blotting, Western; Brain Chemistry; Cyclooxygenase 1; Deoxyguanosine; DNA Damage; Dopaminergic Neurons; Female; Free Radicals; Genotype; Hallucinogens; Male; Mice; Mice, Knockout; N-Methyl-3,4-methylenedioxyamphetamine; N-Methylaspartate; Nerve Degeneration; Oxidative Stress; Presynaptic Terminals; Psychomotor Performance; Reactive Oxygen Species; Stereoisomerism | 2010 |
Temporal dependence of cysteine protease activation following excitotoxic hippocampal injury.
Topics: 2-Amino-5-phosphonovalerate; Animals; Calpain; Cell Death; Cell Survival; Cells, Cultured; Cysteine Proteases; Dipeptides; Enzyme Activation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Hippocampus; Immunohistochemistry; Male; N-Methylaspartate; Nerve Degeneration; Neurons; Organ Culture Techniques; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Synaptophysin | 2012 |
Effect of nafamostat on N-methyl-D-aspartate-induced retinal neuronal and capillary degeneration in rats.
Topics: Animals; Basement Membrane; Benzamidines; Capillaries; Diabetic Neuropathies; Excitatory Amino Acid Agonists; Glaucoma; Glutamic Acid; Guanidines; Intravitreal Injections; Male; N-Methylaspartate; Nerve Degeneration; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Retina; Retinal Diseases; Retinal Ganglion Cells; Retinal Neurons; Retinal Vessels; Serine Proteinase Inhibitors; Severity of Illness Index; Vascular Diseases | 2012 |
Nitric oxide synthase inhibition and glutamate binding in quinolinate-lesioned rat hippocampus.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding, Competitive; Cell Membrane; Excitatory Amino Acid Agonists; Glutamic Acid; Hippocampus; Kainic Acid; Male; Molsidomine; N-Methylaspartate; Nerve Degeneration; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroarginine; Quinolinic Acid; Quisqualic Acid; Rats; Rats, Wistar; Tritium | 2002 |
Smad3-dependent induction of plasminogen activator inhibitor-1 in astrocytes mediates neuroprotective activity of transforming growth factor-beta 1 against NMDA-induced necrosis.
Topics: Animals; Animals, Newborn; Astrocytes; Brain; Calcium Signaling; Cells, Cultured; Coculture Techniques; DNA-Binding Proteins; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Fetus; Mice; N-Methylaspartate; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Plasminogen Activator Inhibitor 1; Recombinant Fusion Proteins; Smad3 Protein; Stroke; Tissue Plasminogen Activator; Trans-Activators; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2002 |
Human immunodeficiency virus type 1 gp120 and ethanol coexposure in rat organotypic brain slice cultures: Curtailment of gp120-induced neurotoxicity and neurotoxic mediators by moderate but not high ethanol concentrations.
Topics: Animals; Arachidonic Acid; Brain; Central Nervous System Depressants; Dose-Response Relationship, Drug; Drug Interactions; Ethanol; Excitatory Amino Acid Agonists; Extracellular Space; Glutamic Acid; Glycine; HIV Envelope Protein gp120; N-Methylaspartate; Nerve Degeneration; Organ Culture Techniques; Rats; Rats, Sprague-Dawley; Superoxides | 2003 |
The antioxidant cocktail, effective microorganism X (EM-X), protects retinal neurons in rats against N-methyl-D-aspartate excitotoxicity in vivo.
Topics: Animals; Antioxidants; Female; N-Methylaspartate; Nerve Degeneration; Probiotics; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Retinal Ganglion Cells | 2003 |
Attenuation of N-methyl-D-aspartate-mediated cytoplasmic vacuolization in primary rat hippocampal neurons by mood stabilizers.
Topics: Animals; Antimanic Agents; Bipolar Disorder; Carbamazepine; Cell Survival; Cells, Cultured; Cytoplasm; Drug Interactions; Fetus; Glial Fibrillary Acidic Protein; Hippocampus; Lithium; Microscopy, Electron; N-Methylaspartate; Nerve Degeneration; Neurons; Neuroprotective Agents; Phosphopyruvate Hydratase; Rats; Treatment Outcome; Vacuoles; Valproic Acid | 2003 |
Activation of mu-calpain in developing cortical neurons following methylmercury treatment.
Topics: Animals; Calpain; Cerebral Cortex; Dizocilpine Maleate; Enzyme Activation; Immunoblotting; Immunohistochemistry; Mercury Poisoning, Nervous System; Methylmercury Compounds; N-Methylaspartate; Nerve Degeneration; Neurons; Neuroprotective Agents; Rats; Rats, Wistar; Spectrin | 2003 |
Interleukin-6, beta-amyloid peptide and NMDA interactions in rat cortical neurons.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Calcium Signaling; Cell Death; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; Drug Interactions; Encephalitis; Excitatory Amino Acid Agonists; Fetus; Glutamic Acid; Interleukin-6; N-Methylaspartate; Nerve Degeneration; Neurons; Neurotoxins; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2003 |
Neuroprotective effect of developmental docosahexaenoic acid supplement against excitotoxic brain damage in infant rats.
Topics: Acetylcholinesterase; Animals; Axons; Basal Nucleus of Meynert; Choline O-Acetyltransferase; Cholinergic Fibers; Dendrites; Docosahexaenoic Acids; Drug Resistance; Female; Food, Formulated; Membrane Lipids; N-Methylaspartate; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Pregnancy; Prenatal Exposure Delayed Effects; Prenatal Nutritional Physiological Phenomena; Rats; Rats, Wistar; Receptor, Nerve Growth Factor; Receptors, Nerve Growth Factor; Treatment Outcome | 2003 |
Cannabinoids inhibit neurodegeneration in models of multiple sclerosis.
Topics: Animals; Aspartic Acid; Axons; Benzoxazines; Cannabinoids; Cyclohexanols; Dizocilpine Maleate; Encephalomyelitis, Autoimmune, Experimental; Excitatory Amino Acid Agonists; Gene Deletion; Humans; Mice; Mice, Transgenic; Monomeric GTP-Binding Proteins; Morpholines; Multiple Sclerosis; N-Methylaspartate; Naphthalenes; Nerve Degeneration; Nuclear Proteins; Receptors, Cannabinoid; Receptors, Drug; Receptors, N-Methyl-D-Aspartate; Retina; Saccharomyces cerevisiae Proteins; Spinal Cord; Uveitis | 2003 |
Excessive production of nitric oxide induces the neuronal cell death in lipopolysaccharide-treated rat hippocampal slice culture.
Topics: Animals; Animals, Newborn; Brain Ischemia; Cell Death; Cerebral Infarction; Enzyme Inhibitors; Hippocampus; Lipopolysaccharides; N-Methylaspartate; Nerve Degeneration; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Organ Culture Techniques; Rats; Rats, Sprague-Dawley; Reaction Time; RNA, Messenger; Up-Regulation | 2003 |
Effect of agmatine against cell death induced by NMDA and glutamate in neurons and PC12 cells.
Topics: Agmatine; Animals; Calcimycin; Cell Death; Cerebral Cortex; Enzyme Inhibitors; Fetus; Glutamic Acid; Ionophores; L-Lactate Dehydrogenase; N-Methylaspartate; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; PC12 Cells; Protein Kinase Inhibitors; Protein Kinases; Rats; Staurosporine | 2003 |
PARP cleavage, DNA fragmentation, and pyknosis during excitotoxin-induced neuronal death.
Topics: Animals; Blotting, Western; Caspase 3; Caspases; Cell Death; Cell Survival; Cerebral Cortex; DNA Fragmentation; Excitatory Amino Acid Agonists; Fluorescent Dyes; In Situ Nick-End Labeling; Kainic Acid; Male; N-Methylaspartate; Nerve Degeneration; Phenotype; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Proteins; Rats; Rats, Long-Evans; Spectrin | 2003 |
Muscimol prevents NMDA antagonist neurotoxicity by activating GABAA receptors in several brain regions.
Topics: Animals; Cell Count; Cerebral Cortex; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Female; Functional Laterality; GABA Agonists; Muscimol; N-Methylaspartate; Nerve Degeneration; Neurotoxicity Syndromes; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Septal Nuclei; Stereotaxic Techniques; Thalamus | 2003 |
Excitotoxic degeneration of hypothalamic orexin neurons in slice culture.
Topics: Animals; Carrier Proteins; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Hypothalamic Hormones; Hypothalamus; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Melanins; N-Methylaspartate; Narcolepsy; Nerve Degeneration; Neurons; Neuropeptides; Neurotoxins; Orexin Receptors; Orexins; Pituitary Hormones; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Quinolinic Acid; Rats; Rats, Wistar; Receptors, G-Protein-Coupled; Receptors, N-Methyl-D-Aspartate; Receptors, Neuropeptide | 2004 |
Naproxen reduces excitotoxic neurodegeneration in vivo with an extended therapeutic window.
Topics: Animals; Dizocilpine Maleate; Male; Mice; N-Methylaspartate; Naproxen; Nerve Degeneration; Neuroprotective Agents; Time Factors | 2004 |
Prevention of neuron and oligodendrocyte degeneration by interleukin-6 (IL-6) and IL-6 receptor/IL-6 fusion protein in organotypic hippocampal slices.
Topics: Active Transport, Cell Nucleus; Animals; Antigens, CD; Astrocytes; Brain Ischemia; Cytokine Receptor gp130; DNA-Binding Proteins; Gliosis; Hippocampus; In Vitro Techniques; Interleukin-6; Membrane Glycoproteins; Myelin Basic Protein; Myelin Proteolipid Protein; N-Methylaspartate; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Oligodendroglia; Phosphorylation; Rats; Receptors, Interleukin-6; Recombinant Fusion Proteins; RNA, Messenger; STAT1 Transcription Factor; STAT3 Transcription Factor; Trans-Activators | 2004 |
Excitotoxin-induced changes in transglutaminase during differentiation of cerebellar granule cells.
Topics: Animals; Animals, Newborn; Cell Differentiation; Cell Survival; Cerebellum; N-Methylaspartate; Nerve Degeneration; Neurons; Neurotoxins; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Time Factors; Transglutaminases | 2004 |
Involvement of RhoA and possible neuroprotective effect of fasudil, a Rho kinase inhibitor, in NMDA-induced neurotoxicity in the rat retina.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Count; Disease Models, Animal; Drug Interactions; Enzyme Inhibitors; Glutamic Acid; Intracellular Signaling Peptides and Proteins; Male; N-Methylaspartate; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Protein Serine-Threonine Kinases; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Retina; Retinal Degeneration; Retinal Ganglion Cells; rho-Associated Kinases; rhoA GTP-Binding Protein; RNA, Messenger; Thy-1 Antigens; Up-Regulation | 2004 |
Neonatal handling increases sensitivity to acute neurodegeneration in adult rats.
Topics: Acetylcholine; Acetylcholinesterase; Animals; Animals, Newborn; Basal Nucleus of Meynert; Cell Death; Choline O-Acetyltransferase; Cholinergic Fibers; Corticosterone; Female; Functional Laterality; Handling, Psychological; Immunity, Innate; Immunohistochemistry; Male; Maternal Deprivation; N-Methylaspartate; Nerve Degeneration; Neurotoxins; Rats; Rats, Wistar; Stress, Psychological | 2004 |
Intraischaemic hypothermia reduces free radical production and protects against ischaemic insults in cultured hippocampal slices.
Topics: Animals; Animals, Newborn; Brain Ischemia; Cell Hypoxia; Cytoprotection; Excitatory Amino Acid Agonists; Fluorescent Dyes; Free Radicals; Glucose; Hippocampus; Hypothermia, Induced; In Vitro Techniques; N-Methylaspartate; Nerve Degeneration; Neurons; Nitric Oxide; Rats; Rats, Wistar; Superoxides; Temperature; Time Factors | 2004 |
Role of inducible nitric oxide synthase in N-methyl-d-aspartic acid-induced strio-nigral degeneration.
Topics: Animals; Functional Laterality; Guanidines; Immunohistochemistry; Inflammation; Interneurons; Male; Motor Activity; N-Methylaspartate; NADPH Dehydrogenase; Neostriatum; Nerve Degeneration; Neuroglia; Neurons; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Rats; Rats, Wistar; Tyrosine | 2004 |
BMP4 and CNTF are neuroprotective and suppress damage-induced proliferation of Müller glia in the retina.
Topics: Animals; Bone Morphogenetic Protein 4; Bone Morphogenetic Protein 7; Bone Morphogenetic Proteins; Cell Death; Cell Proliferation; Chick Embryo; Cicatrix; Ciliary Neurotrophic Factor; Gliosis; N-Methylaspartate; Nerve Degeneration; Nerve Growth Factors; Neuroglia; Neuroprotective Agents; Neurotoxins; Retina; Retinal Diseases; Transforming Growth Factor beta | 2004 |
Increased susceptibility of glutathione peroxidase-1 transgenic mice to kainic acid-related seizure activity and hippocampal neuronal cell death.
Topics: Animals; Cell Death; Cells, Cultured; Disease Models, Animal; Epilepsy; Genetic Predisposition to Disease; Glutathione Disulfide; Glutathione Peroxidase; Hippocampus; Kainic Acid; Mice; Mice, Transgenic; N-Methylaspartate; Nerve Degeneration; Neurons; Neurotoxins; Organ Culture Techniques; Oxidative Stress; Receptors, N-Methyl-D-Aspartate; Up-Regulation | 2005 |
Protection by cholesterol-extracting cyclodextrins: a role for N-methyl-D-aspartate receptor redistribution.
Topics: Animals; Calcium; Calcium Signaling; Cells, Cultured; Cholesterol; Cyclodextrins; Cytoprotection; Disks Large Homolog 4 Protein; Excitatory Amino Acid Antagonists; Glutamic Acid; Hypoxia-Ischemia, Brain; Intracellular Signaling Peptides and Proteins; Membrane Microdomains; Membrane Proteins; Methylation; N-Methylaspartate; Nerve Degeneration; Nerve Tissue Proteins; Neurons; Neuroprotective Agents; Neurotoxins; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Rats; Receptor Aggregation; Receptors, N-Methyl-D-Aspartate; Sulfur Compounds; Synaptic Transmission | 2005 |
Vascular endothelial growth factor counteracts NMDA-induced cell death of adult cholinergic neurons in rat basal nucleus of Meynert.
Topics: Age Factors; Alzheimer Disease; Animals; Axotomy; Basal Nucleus of Meynert; Blood Vessels; Cell Death; Choline O-Acetyltransferase; Cholinergic Fibers; Disease Models, Animal; Excitatory Amino Acid Agonists; Immunohistochemistry; Laminin; Male; N-Methylaspartate; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Organ Culture Techniques; Rats; Rats, Sprague-Dawley; Vascular Endothelial Growth Factor A | 2005 |
The p53-independent nuclear translocation of cyclin G1 in degenerating neurons by ischemic and traumatic insults.
Topics: Animals; Brain Injuries; Brain Ischemia; Cell Death; Cells, Cultured; Cyclin G; Cyclin G1; Cyclins; Cycloheximide; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Embryo, Mammalian; Excitatory Amino Acid Agonists; Fluoresceins; Fluorescent Dyes; Gene Expression Regulation; Gerbillinae; Immunohistochemistry; In Situ Hybridization; In Situ Nick-End Labeling; Kainic Acid; Mice; Mice, Knockout; Microscopy, Immunoelectron; N-Methylaspartate; Nerve Degeneration; Neurons; Organic Chemicals; Phosphopyruvate Hydratase; Protein Synthesis Inhibitors; Rats; Rats, Wistar; Time Factors; Tumor Suppressor Protein p53 | 2005 |
Cyclo-oxygenase-1 and -2 differently contribute to prostaglandin E2 synthesis and lipid peroxidation after in vivo activation of N-methyl-D-aspartate receptors in rat hippocampus.
Topics: Animals; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Excitatory Amino Acid Agonists; Hippocampus; Lipid Peroxidation; Male; Membrane Proteins; Microdialysis; N-Methylaspartate; Nerve Degeneration; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2005 |
Galantamine-induced behavioral recovery after sublethal excitotoxic lesions to the rat medial septum.
Topics: Acetylcholinesterase; Analysis of Variance; Animals; Behavior, Animal; Choline O-Acetyltransferase; Cholinergic Fibers; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Galantamine; Hippocampus; Male; Maze Learning; Models, Animal; N-Methylaspartate; Nerve Degeneration; Neural Pathways; Neurotoxins; Nicotinic Antagonists; Rats; Rats, Wistar; Receptors, Nicotinic; Septal Nuclei; Space Perception | 2005 |
Dopaminergic neurotoxins require excitotoxic stimulation in organotypic cultures.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Animals, Newborn; Brain; Cell Death; Cell Nucleus; Cerebral Cortex; Corpus Striatum; Dopamine; Drug Synergism; Glutamic Acid; N-Methylaspartate; Nerve Degeneration; Neurons; Neurotoxins; Organ Culture Techniques; Oxidopamine; Parkinson Disease; Rats; Rats, Sprague-Dawley; Rotenone; Substantia Nigra; Tyrosine 3-Monooxygenase | 2005 |
Mitochondrial nitric oxide mediates decreased vulnerability of hippocampal neurons from immature animals to NMDA.
Topics: Animals; Animals, Newborn; Calcium; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Cells, Cultured; Clonazepam; Hippocampus; Indazoles; Ion Transport; Mitochondria; N-Methylaspartate; Nerve Degeneration; Nerve Tissue Proteins; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type I; Oxadiazoles; Oxygen; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Ruthenium Compounds; Thiazepines | 2005 |
Alterations in N-methyl-D-aspartate receptor sensitivity and magnesium blockade occur early in development in the R6/2 mouse model of Huntington's disease.
Topics: Animals; Cell Death; Cells, Cultured; Corpus Striatum; Disease Models, Animal; Drug Resistance; Excitatory Amino Acid Agonists; Humans; Huntingtin Protein; Huntington Disease; Magnesium; Membrane Potentials; Mice; Mice, Transgenic; N-Methylaspartate; Nerve Degeneration; Nerve Tissue Proteins; Neurons; Nuclear Proteins; Patch-Clamp Techniques; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 2005 |
Retigabine and flupirtine exert neuroprotective actions in organotypic hippocampal cultures.
Topics: Aminopyridines; Animals; Carbamates; Culture Media, Serum-Free; Glucose; Hippocampus; KCNQ Potassium Channels; N-Methylaspartate; Nerve Degeneration; Neuroprotective Agents; Oxygen; Phenylenediamines; Rats; Rats, Wistar; Reactive Oxygen Species; Receptors, N-Methyl-D-Aspartate; Tissue Culture Techniques | 2006 |
Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin.
Topics: Active Transport, Cell Nucleus; Animals; Brain; Caspase 6; Caspases; Cell Nucleus; Humans; Huntingtin Protein; Huntington Disease; Hydrolysis; Mice; Mice, Transgenic; Mutation; N-Methylaspartate; Nerve Degeneration; Nerve Tissue Proteins; Neurons; Nuclear Proteins; Quinolinic Acid; Staurosporine | 2006 |
A novel organotypic culture model of the postnatal mouse retina allows the study of glutamate-mediated excitotoxicity.
Topics: Animals; Apoptosis; Culture Media; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Glutamic Acid; Immunohistochemistry; In Situ Nick-End Labeling; Mice; Mice, Inbred C57BL; Microscopy, Fluorescence; Models, Neurological; N-Methylaspartate; Nerve Degeneration; Organ Culture Techniques; Retina; Retinal Ganglion Cells | 2007 |
Oral treatment with rofecoxib reduces hippocampal excitotoxic neurodegeneration.
Topics: Animals; Blotting, Western; Brain Edema; Cell Death; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Excitatory Amino Acid Agonists; Hippocampus; Lactones; Male; Mice; Microinjections; N-Methylaspartate; Naproxen; Nerve Degeneration; Neurons; Neuroprotective Agents; Sulfones | 2006 |
Cannabinoids and neuronal damage: differential effects of THC, AEA and 2-AG on activated microglial cells and degenerating neurons in excitotoxically lesioned rat organotypic hippocampal slice cultures.
Topics: Animals; Animals, Newborn; Arachidonic Acids; Brain; Brain Damage, Chronic; Cannabinoids; Cell Count; Disease Models, Animal; Dronabinol; Endocannabinoids; Gliosis; Glycerides; Microglia; N-Methylaspartate; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Organ Culture Techniques; Plant Lectins; Polyunsaturated Alkamides; Rats; Rats, Wistar; Receptor, Cannabinoid, CB2; Treatment Outcome | 2007 |
The HSV-2 protein ICP10PK prevents neuronal apoptosis and loss of function in an in vivo model of neurodegeneration associated with glutamate excitotoxicity.
Topics: Animals; Apomorphine; Apoptosis; Behavior, Animal; Chlorocebus aethiops; Coloring Agents; Dopamine Agonists; Electron Transport Complex IV; Excitatory Amino Acids; Glutamic Acid; Immunohistochemistry; In Situ Nick-End Labeling; Indicators and Reagents; Injections; Male; Mice; Mitogen-Activated Protein Kinase Kinases; N-Methylaspartate; Neostriatum; Nerve Degeneration; Neurons; Neuroprotective Agents; Phenothiazines; Protein Serine-Threonine Kinases; Ribonucleotide Reductases; Vero Cells | 2007 |
Delayed neurodegeneration and early astrogliosis after excitotoxicity to the aged brain.
Topics: Aging; Animals; Astrocytes; Brain; Brain Edema; Cell Count; Corpus Striatum; Excitatory Amino Acid Agonists; Glial Fibrillary Acidic Protein; Gliosis; Immunohistochemistry; Male; N-Methylaspartate; Nerve Degeneration; Neurons; Rats; Rats, Wistar; Time Factors | 2007 |
The direct and indirect effects of serofendic acid on neuroprotection.
Topics: Animals; Astrocytes; Cell Survival; Cells, Cultured; Cytokines; Diterpenes; Glutamic Acid; Mice; Mice, Inbred C57BL; N-Methylaspartate; Nerve Degeneration; Nerve Growth Factors; Neuroglia; Neurons; Neuroprotective Agents | 2006 |
Neuroprotective effect of carnosine on necrotic cell death in PC12 cells.
Topics: Animals; Carnosine; Central Nervous System; Dose-Response Relationship, Drug; Energy Metabolism; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Histamine H1 Antagonists; Methylhistidines; Mitochondria; N-Methylaspartate; Necrosis; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; PC12 Cells; Pyrilamine; Rats; Receptors, Histamine H1 | 2007 |
Excitotoxic motoneuron disease in chick embryo evolves with autophagic neurodegeneration and deregulation of neuromuscular innervation.
Topics: Age Factors; Animals; Autophagy; Calcitonin Gene-Related Peptide; Calcium; Chick Embryo; Curare; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Gene Expression Regulation, Developmental; Microscopy, Electron, Transmission; Motor Neuron Disease; Motor Neurons; N-Methylaspartate; Nerve Degeneration; Neuromuscular Junction; Neuromuscular Nondepolarizing Agents; Receptors, Nicotinic; Spinal Cord; Tubulin | 2007 |
The developmental expression of fluorescent proteins in organotypic hippocampal slice cultures from transgenic mice and its use in the determination of excitotoxic neurodegeneration.
Topics: Animals; Animals, Newborn; Astrocytes; Biomarkers; Cells, Cultured; Excitatory Amino Acid Antagonists; Green Fluorescent Proteins; Hippocampus; Mice; Mice, Transgenic; Microscopy, Fluorescence; N-Methylaspartate; Nerve Degeneration; Neurons; Time Factors; Tissue Culture Techniques | 2007 |
Excitotoxicity-related endocytosis in cortical neurons.
Topics: Active Transport, Cell Nucleus; Animals; Animals, Newborn; Calcium Signaling; Cell Death; Cells, Cultured; Cerebral Cortex; Dextrans; Endocytosis; Excitatory Amino Acid Agonists; Fluorescein-5-isothiocyanate; JNK Mitogen-Activated Protein Kinases; Models, Biological; N-Methylaspartate; Nerve Degeneration; Neurons; Neurotoxins; Rats; Rats, Sprague-Dawley | 2007 |
Caspase-3 activation in astrocytes following postnatal excitotoxic damage correlates with cytoskeletal remodeling but not with cell death or proliferation.
Topics: Animals; Animals, Newborn; Astrocytes; Brain; Brain Damage, Chronic; Caspase 3; Cell Death; Cell Proliferation; Cell Size; Cytoskeleton; Enzyme Activation; Female; Glial Fibrillary Acidic Protein; Gliosis; Intermediate Filaments; Male; N-Methylaspartate; Nerve Degeneration; Neurotoxins; Rats; Rats, Long-Evans; Vimentin | 2007 |
Subtoxic N-methyl-D-aspartate delayed neuronal death in ischemic brain injury through TrkB receptor- and calmodulin-mediated PI-3K/Akt pathway activation.
Topics: Animals; Brain Infarction; Brain Ischemia; Brain-Derived Neurotrophic Factor; Calcium Signaling; Calmodulin; Cell Survival; Enzyme Activation; Enzyme Inhibitors; Hippocampus; Male; N-Methylaspartate; Nerve Degeneration; Neuroprotective Agents; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Subunits; Proto-Oncogene Proteins c-akt; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptor, trkB; Reperfusion Injury; Signal Transduction | 2007 |
Dopamine receptor activation reveals a novel, kynurenate-sensitive component of striatal N-methyl-D-aspartate neurotoxicity.
Topics: Animals; Astrocytes; Cell Death; Corpus Striatum; Dopamine; Dopamine Agonists; Excitatory Amino Acid Agonists; Female; Glutamic Acid; Humans; Kynurenic Acid; N-Methylaspartate; Nerve Degeneration; Neurotoxins; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Receptors, N-Methyl-D-Aspartate | 2007 |
RGD domains neuroprotect the immature brain by a glial-dependent mechanism.
Topics: Animals; Astrocytes; Behavior, Animal; Brain; Brain Chemistry; Cell Count; Cell Survival; Cells, Cultured; Culture Media, Conditioned; Data Interpretation, Statistical; Densitometry; Excitatory Amino Acids; Female; Immunohistochemistry; Microglia; N-Methylaspartate; Nerve Degeneration; Neuroglia; Neurons; Neuroprotective Agents; Neurotoxicity Syndromes; Neutrophil Infiltration; Oligopeptides; Pregnancy; Rats; Rats, Long-Evans | 2007 |
Growth-compromised HSV-2 vector Delta RR protects from N-methyl-D-aspartate-induced neuronal degeneration through redundant activation of the MEK/ERK and PI3-K/Akt survival pathways, either one of which overrides apoptotic cascades.
Topics: Animals; Apoptosis; Cell Survival; Chlorocebus aethiops; Corpus Striatum; Excitatory Amino Acid Agonists; Fluorescent Antibody Technique; Genetic Therapy; Genetic Vectors; Herpesvirus 2, Human; Immunoblotting; In Situ Nick-End Labeling; Mitogen-Activated Protein Kinases; N-Methylaspartate; Nerve Degeneration; Neurons; Phosphatidylinositol 3-Kinases; Protein Serine-Threonine Kinases; Rats; Rats, Sprague-Dawley; Ribonucleotide Reductases; Vero Cells | 2008 |
A Golgi fragmentation pathway in neurodegeneration.
Topics: Analysis of Variance; Animals; Apoptosis; Cells, Cultured; Cerebral Cortex; Cysteine; Dose-Response Relationship, Drug; Embryo, Mammalian; Excitatory Amino Acid Agonists; Golgi Apparatus; Luminescent Proteins; Mitochondria; N-Methylaspartate; Nerve Degeneration; Neurons; Nitric Oxide Donors; Rats; S-Nitrosothiols; Signal Transduction; Time Factors; Transfection; Tubulin | 2008 |
A highly sulfated chondroitin sulfate preparation, CS-E, prevents excitatory amino acid-induced neuronal cell death.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Caspase 3; Cell Death; Cell Survival; Chondroitin Sulfates; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Female; Kainic Acid; Membrane Potentials; N-Methylaspartate; Neocortex; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Phosphorylation; Polyelectrolytes; Polymers; Pregnancy; Rats; Rats, Sprague-Dawley; Tyrosine | 2008 |
Histological evidence for drug diffusion across the cerebral meninges into the underlying neocortex in rats.
Topics: Animals; Cell Death; Coloring Agents; Diffusion; Epidural Space; Indicators and Reagents; Infusion Pumps, Implantable; Male; Meninges; Methylene Blue; N-Methylaspartate; Neocortex; Nerve Degeneration; Neurotoxins; Rats; Rats, Long-Evans; Solubility; Subarachnoid Space; Subdural Space | 2008 |
Different behavioral effects of neurotoxic dorsal hippocampal lesions placed under either isoflurane or propofol anesthesia.
Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Behavior, Animal; Denervation; Hippocampus; Isoflurane; Learning; Learning Disabilities; Male; Memory; Memory Disorders; N-Methylaspartate; Nerve Degeneration; Neurotoxins; Propofol; Rats; Rats, Inbred F344 | 2008 |
Rats with hippocampal lesion show impaired learning and memory in the ziggurat task: a new task to evaluate spatial behavior.
Topics: Animals; Association Learning; Behavioral Research; Exploratory Behavior; Goals; Hippocampus; Male; Maze Learning; Memory; N-Methylaspartate; Nerve Degeneration; Neurons; Neurotoxins; Orientation; Rats; Rats, Long-Evans; Reaction Time; Space Perception; Spatial Behavior | 2008 |
Survivin and heat shock protein 25/27 colocalize with cleaved caspase-3 in surviving reactive astrocytes following excitotoxicity to the immature brain.
Topics: Animals; Animals, Newborn; Apoptosis; Astrocytes; Brain; Caspase 3; Cell Nucleus; Cell Survival; Cytoplasm; Female; Gliosis; Heat-Shock Proteins; HSP27 Heat-Shock Proteins; HSP72 Heat-Shock Proteins; Inhibitor of Apoptosis Proteins; Male; Microtubule-Associated Proteins; N-Methylaspartate; Neoplasm Proteins; Nerve Degeneration; Neurons; Neurotoxins; Rats; Rats, Long-Evans; Survivin | 2008 |
Lysosomal release of cathepsins causes ischemic damage in the rat hippocampal slice and depends on NMDA-mediated calcium influx, arachidonic acid metabolism, and free radical production.
Topics: Animals; Arachidonic Acid; Calcium; Calcium Signaling; Calpain; Cathepsin B; Cathepsins; Cell Death; Cell Membrane Permeability; Excitatory Amino Acid Agonists; Extracellular Signal-Regulated MAP Kinases; Free Radicals; Hippocampus; Hypoxia-Ischemia, Brain; Lysosomes; Male; N-Methylaspartate; Nerve Degeneration; Neurons; Organ Culture Techniques; Oxidative Stress; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2008 |
Substantial migration of SVZ cells to the cortex results in the generation of new neurons in the excitotoxically damaged immature rat brain.
Topics: Age Factors; Animals; Astrocytes; Biomarkers; Calbindin 2; Cell Differentiation; Cell Division; Cell Movement; Excitatory Amino Acid Agonists; Female; Gliosis; Internal Capsule; Male; Motor Cortex; N-Methylaspartate; Nerve Degeneration; Nerve Tissue Proteins; Neurons; Neurotoxins; Rats; Rats, Long-Evans; Receptors, CXCR4; Receptors, Immunologic; Roundabout Proteins; S100 Calcium Binding Protein G; Somatosensory Cortex; Stem Cells | 2008 |
Degenerative alterations in the visual pathway after NMDA-induced retinal damage in mice.
Topics: Animals; Astrocytes; Brain-Derived Neurotrophic Factor; Functional Laterality; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Male; Mice; Mice, Inbred C57BL; N-Methylaspartate; Nerve Degeneration; Neurons; Phosphopyruvate Hydratase; Retinal Diseases; Time Factors; Visual Pathways | 2008 |
Somatostatin in medium-sized aspiny interneurons of striatum is responsible for their preservation in quinolinic acid and N-methyl-D-asparate-induced neurotoxicity.
Topics: Animals; Antibodies; Cell Survival; Cells, Cultured; Cytoprotection; Excitatory Amino Acid Antagonists; Interneurons; N-Methylaspartate; NADPH Dehydrogenase; Neostriatum; Nerve Degeneration; Neurotoxins; Oligonucleotides, Antisense; Pertussis Toxin; Quinolinic Acid; Rats; Receptors, Somatostatin; Somatostatin | 2008 |
Hippocampal lesions in rats impair learning and memory for locations on a touch-sensitive computer screen: the "ASAT" task.
Topics: Animals; Association Learning; Behavior, Animal; Behavioral Research; Excitatory Amino Acid Agonists; Exploratory Behavior; Hippocampus; Male; Maze Learning; Memory; Microinjections; N-Methylaspartate; Nerve Degeneration; Neurons; Neurotoxins; Rats; Reward; Space Perception; Spatial Behavior; Task Performance and Analysis | 2008 |
Correlation between anti-ubiquitin immunoreactivity and region-specific neuronal death in N-methyl-D-aspartate-treated rat hippocampal organotypic cultures.
Topics: Animals; Axons; Electrophysiology; Excitatory Amino Acid Agonists; Hippocampus; Immunoblotting; Immunohistochemistry; Microscopy, Fluorescence; N-Methylaspartate; Nerve Degeneration; Organ Culture Techniques; Propidium; Pyramidal Cells; Rats; Ubiquitins | 1995 |
NMDA prevents alcohol-induced neuronal cell death of cerebellar granule cells in culture.
Topics: Animals; Cell Differentiation; Cell Survival; Cells, Cultured; Cerebellum; Cytoplasmic Granules; Dose-Response Relationship, Drug; Embryo, Mammalian; Female; Gestational Age; Male; N-Methylaspartate; Nerve Degeneration; Neurons; Pregnancy; Rats; Receptors, N-Methyl-D-Aspartate | 1995 |
Neuronal damage induced by beta-N-oxalylamino-L-alanine, in the rat hippocampus, can be prevented by a non-NMDA antagonist, 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids, Diamino; Animals; beta-Alanine; Dizocilpine Maleate; Dose-Response Relationship, Drug; Hippocampus; Kainic Acid; Male; N-Methylaspartate; Nerve Degeneration; Neurons; Quinoxalines; Rats; Rats, Wistar | 1993 |
2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(f)quinoxaline protects against both AMPA and kainate-induced lesions in rat striatum in vivo.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Biomarkers; Choline O-Acetyltransferase; Corpus Striatum; Glutamate Decarboxylase; Kainic Acid; Male; N-Methylaspartate; Nerve Degeneration; Nerve Tissue Proteins; Quinoxalines; Rats; Rats, Wistar; Receptors, Glutamate | 1994 |
Propofol protects cultured rat hippocampal neurons against N-methyl-D-aspartate receptor-mediated glutamate toxicity.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Ischemia; Cells, Cultured; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Fetus; Glutamic Acid; Hippocampus; Kainic Acid; N-Methylaspartate; Nerve Degeneration; Neurons; Phosphopyruvate Hydratase; Propofol; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Time Factors | 1994 |
Nitric oxide does not mediate acute glutamate neurotoxicity, nor is it neuroprotective, in rat brain slices.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Cerebellum; Excitatory Amino Acids; Glutamic Acid; Hippocampus; In Vitro Techniques; N-Methylaspartate; Nerve Degeneration; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Rats; Rats, Wistar | 1994 |
Interleukin-1 beta attenuates excitatory amino acid-induced neurodegeneration in vitro: involvement of nerve growth factor.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analysis of Variance; Animals; Antibodies, Monoclonal; Cell Death; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Excitatory Amino Acids; Fetus; Glutamic Acid; Humans; Interleukin 1 Receptor Antagonist Protein; Interleukin-1; Kainic Acid; Kinetics; N-Methylaspartate; Nerve Degeneration; Nerve Growth Factors; Neurons; Neurotoxins; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Sialoglycoproteins | 1995 |
Ca2+ permeable AMPA/kainate channels permit rapid injurious Ca2+ entry.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Calcium Channels; Cell Count; Cells, Cultured; Cobalt; Dose-Response Relationship, Drug; Kainic Acid; Mice; Mice, Inbred Strains; N-Methylaspartate; Nerve Degeneration; Receptors, AMPA; Receptors, Kainic Acid | 1995 |
Staurosporine-induced neuronal apoptosis.
Topics: Alkaloids; Animals; Apoptosis; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors; Kainic Acid; Mice; Mice, Inbred Strains; N-Methylaspartate; Nerve Degeneration; Neurons; Staurosporine; Time Factors | 1995 |
(1S,2S)-1-(4-hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidino)-1-propanol: a potent new neuroprotectant which blocks N-methyl-D-aspartate responses.
Topics: Animals; Cell Death; Cells, Cultured; Genes, fos; Hippocampus; Male; Mice; N-Methylaspartate; Nerve Degeneration; Piperidines; Rats; Structure-Activity Relationship | 1995 |
Glutamate receptor-induced 45Ca2+ accumulation in cortical cell culture correlates with subsequent neuronal degeneration.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Calcium Radioisotopes; Cells, Cultured; Cerebral Cortex; Glutamates; Glutamic Acid; Ibotenic Acid; N-Methylaspartate; Nerve Degeneration; Neurons; Quinoxalines; Receptors, Glutamate | 1993 |
Competitive and non-competitive NMDA antagonists induce similar limbic degeneration.
Topics: Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Isoquinolines; Limbic System; N-Methylaspartate; Nerve Degeneration; Phencyclidine; Rats; Time Factors | 1994 |
Potentiated necrosis of cultured cortical neurons by neurotrophins.
Topics: Animals; Apoptosis; Brain-Derived Neurotrophic Factor; Calcium; Cell Death; Cells, Cultured; Cerebral Cortex; Dizocilpine Maleate; Mice; N-Methylaspartate; Necrosis; Nerve Degeneration; Nerve Growth Factors; Nerve Tissue Proteins; Neurons; Neurotrophin 3; Quinoxalines; Receptors, AMPA | 1995 |
Protective action of idebenone against excitotoxic degeneration in cultured cortical neurons.
Topics: Animals; Benzoquinones; Cells, Cultured; Cerebral Cortex; Dizocilpine Maleate; Mice; N-Methylaspartate; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Time Factors; Ubiquinone | 1994 |
Nicotine protects cultured striatal neurones against N-methyl-D-aspartate receptor-mediated neurotoxicity.
Topics: Acetylcholine; Animals; Carbachol; Cells, Cultured; Dimethylphenylpiperazinium Iodide; Hexamethonium; Mice; N-Methylaspartate; Neostriatum; Nerve Degeneration; Nervous System Diseases; Neurons; Nicotine; Receptors, Cholinergic; Receptors, N-Methyl-D-Aspartate; Receptors, Nicotinic | 1994 |
Dextrorphan attenuates the behavioral consequences of ischemia and the biochemical consequences of anoxia: possible role of N-methyl-d-aspartate receptor antagonism and ATP replenishing action in its cerebroprotecting profile.
Topics: Adenosine Triphosphate; Adenylyl Cyclases; Animals; Avoidance Learning; Behavior, Animal; Brain Ischemia; Dextrorphan; Dizocilpine Maleate; Exploratory Behavior; Hypoxia, Brain; Injections, Intraventricular; Male; Maze Learning; Mice; Mice, Inbred ICR; Mice, Inbred Strains; N-Methylaspartate; Nerve Degeneration; Oxidative Phosphorylation; Postural Balance; Potassium Cyanide; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 1993 |
An aggregate brain cell culture model for studying neuronal degeneration and regeneration.
Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Acetylcholinesterase; Animals; Biomarkers; Cell Aggregation; Choline O-Acetyltransferase; Dizocilpine Maleate; DNA; Fetus; Gestational Age; Glutamate-Ammonia Ligase; Glutamic Acid; L-Lactate Dehydrogenase; N-Methylaspartate; Nerve Degeneration; Nerve Regeneration; Neuroglia; Neurons; Rats; Reproducibility of Results; Telencephalon | 1994 |
Comparison of double fluorescence staining and LDH-test for monitoring cell viability in vitro.
Topics: Animals; Biomarkers; Cell Survival; Cells, Cultured; Cerebral Cortex; Culture Media, Conditioned; Cytological Techniques; Fluoresceins; Fluorescent Dyes; Glutamates; Glutamic Acid; Hydrolysis; Kainic Acid; L-Lactate Dehydrogenase; Microscopy, Fluorescence; N-Methylaspartate; Nerve Degeneration; Nerve Tissue Proteins; Neuroglia; Neurons; Neurotoxins; Propidium; Quinolinic Acid; Rats; Rats, Wistar | 1993 |
The competitive NMDA antagonist CPP protects substantia nigra neurons from MPTP-induced degeneration in primates.
Topics: Animals; Behavior, Animal; Biogenic Monoamines; Callithrix; Female; Immunohistochemistry; Male; MPTP Poisoning; N-Methylaspartate; Nerve Degeneration; Neurons; Piperazines; Putamen; Receptors, N-Methyl-D-Aspartate; Substantia Nigra; Tyrosine 3-Monooxygenase | 1993 |
Re-expression of glia-derived nexin/protease nexin 1 depends on mode of lesion-induction or terminal degeneration: observations after excitotoxin or 6-hydroxydopamine lesions of rat substantia nigra.
Topics: Amyloid beta-Protein Precursor; Animals; Carrier Proteins; Glial Fibrillary Acidic Protein; Ibotenic Acid; Immunohistochemistry; Male; N-Methylaspartate; Nerve Degeneration; Oxidopamine; Protease Nexins; Putamen; Quisqualic Acid; Rats; Rats, Wistar; Receptors, Cell Surface; Receptors, Glutamate; Substantia Nigra; Tyrosine 3-Monooxygenase; Up-Regulation | 1994 |
Zinc toxicity on cultured cortical neurons: involvement of N-methyl-D-aspartate receptors.
Topics: Animals; Cell Death; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Mice; Mice, Inbred Strains; N-Methylaspartate; Nerve Degeneration; Neurons; Receptors, N-Methyl-D-Aspartate; Zinc | 1994 |
Intracerebral injection of human immunodeficiency virus type 1 coat glycoprotein GP120 does not produce neurodegeneration in rats.
Topics: Animals; Cerebral Ventricles; Drug Administration Schedule; Hippocampus; HIV Envelope Protein gp120; HIV-1; Infusions, Parenteral; Male; Motor Activity; N-Methylaspartate; Nerve Degeneration; Neurotoxins; Posture; Rats; Rats, Wistar; Recombinant Proteins; Stereotaxic Techniques; Time Factors | 1994 |
Glutamate receptor binding in juvenile and adult Rana pipiens CNS.
Topics: Afferent Pathways; Animals; Axons; Brain; Eye Enucleation; Horseradish Peroxidase; N-Methylaspartate; Nerve Degeneration; Quisqualic Acid; Rana pipiens; Receptors, Glutamate | 1994 |
Glutamate neurotoxicity: a role for non-N-methyl-D-aspartate receptors?
Topics: Animals; Brain; Cells, Cultured; Choline O-Acetyltransferase; Glutamates; Glutamic Acid; Kainic Acid; N-Methylaspartate; Nerve Degeneration; Quisqualic Acid; Rats; Receptors, N-Methyl-D-Aspartate; Somatostatin | 1993 |
The NMDA receptor agonist DL-(tetrazol-5-yl)glycine is a highly potent excitotoxin.
Topics: Animals; Animals, Newborn; Brain; Choline O-Acetyltransferase; Female; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamates; Glycine; Male; N-Methylaspartate; Nerve Degeneration; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Tetrazoles | 1994 |
Selective excitotoxic pathology in the rat hippocampus.
Topics: Animals; Brain; Brain Damage, Chronic; Cell Death; Hippocampus; Ibotenic Acid; Kainic Acid; Male; N-Methylaspartate; Nerve Degeneration; Neurotoxins; Organ Specificity; Piperazines; Quisqualic Acid; Rats; Rats, Sprague-Dawley | 1993 |
Ethanol inhibits NMDA receptor-mediated excitotoxicity in rat primary neuronal cultures.
Topics: Animals; Brain; Cells, Cultured; Ethanol; Female; Glycine; L-Lactate Dehydrogenase; N-Methylaspartate; Nerve Degeneration; Neural Inhibition; Neurons; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 1993 |
NMDA neurotoxicity in murine cortical cell cultures is not attenuated by hemoglobin or inhibition of nitric oxide synthesis.
Topics: Animals; Cells, Cultured; Cerebral Cortex; Dizocilpine Maleate; Hemoglobins; Mice; N-Methylaspartate; Nerve Degeneration; Neurons; Neurotoxins; Nitric Oxide | 1993 |
Activation of class II or III metabotropic glutamate receptors protects cultured cortical neurons against excitotoxic degeneration.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Astrocytes; Biotransformation; Cells, Cultured; Cerebral Cortex; Colforsin; Cyclic AMP; Excitatory Amino Acid Agonists; Excitatory Amino Acids; Extracellular Space; Mice; N-Methylaspartate; Nerve Degeneration; Neuroglia; Neurons; Receptors, Metabotropic Glutamate | 1995 |
Activation of metabotropic glutamate receptors coupled to inositol phospholipid hydrolysis amplifies NMDA-induced neuronal degeneration in cultured cortical cells.
Topics: Amino Acid Sequence; Animals; Blotting, Northern; Cells, Cultured; Cerebral Cortex; Excitatory Amino Acid Agonists; Excitatory Amino Acids; Hydrolysis; Immunohistochemistry; Mice; Molecular Sequence Data; N-Methylaspartate; Nerve Degeneration; Neuroglia; Nucleic Acid Hybridization; Phorbol Esters; Phosphatidylinositols; Receptors, Metabotropic Glutamate; RNA | 1995 |
Traumatic brain damage prevented by the non-N-methyl-D-aspartate antagonist 2,3-dihydroxy-6-nitro-7-sulfamoylbenzo[f] quinoxaline.
Topics: Animals; Brain Injuries; Cerebral Cortex; Disease Models, Animal; Excitatory Amino Acid Antagonists; Hippocampus; Humans; Male; N-Methylaspartate; Nerve Degeneration; Neurons; Piperazines; Quinoxalines; Rats; Rats, Inbred F344; Time Factors; Wounds, Nonpenetrating | 1996 |
Schwann cell apoptosis during normal development and after axonal degeneration induced by neurotoxins in the chick embryo.
Topics: Animals; Apoptosis; Axons; Bungarotoxins; Chick Embryo; Fluorescent Antibody Technique; Ganglia, Invertebrate; Ganglia, Spinal; Microscopy, Electron; Motor Neurons; N-Methylaspartate; Nerve Degeneration; Neurotoxins; Schwann Cells; Spinal Nerve Roots | 1996 |
Microglial response to N-methyl-D-aspartate-mediated excitotoxicity in the immature rat brain.
Topics: Animals; Brain Ischemia; Disease Models, Animal; Efferent Pathways; Female; Hippocampus; Male; Microglia; N-Methylaspartate; Nerve Degeneration; Rats; Somatosensory Cortex; Thalamus; Wallerian Degeneration | 1996 |
1-Aminocyclopropane-carboxylic acid reduces NMDA-induced hippocampal neurodegeneration in vivo.
Topics: Amino Acids; Amino Acids, Cyclic; Animals; Excitatory Amino Acid Agonists; Hippocampus; Injections; Injections, Intraperitoneal; Male; Mice; N-Methylaspartate; Nerve Degeneration; Pyramidal Cells; Receptors, N-Methyl-D-Aspartate; Seizures | 1996 |
Ca(2+)-permeable AMPA/kainate and NMDA channels: high rate of Ca2+ influx underlies potent induction of injury.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Calcium Channels; Intracellular Membranes; Kainic Acid; Mice; Mice, Inbred Strains; N-Methylaspartate; Nerve Degeneration; Osmolar Concentration; Permeability; Time Factors | 1996 |
Marked diversity in the action of growth factors on N-methyl-D-aspartate-induced neuronal degeneration.
Topics: Animals; Brain-Derived Neurotrophic Factor; Cell Culture Techniques; Epidermal Growth Factor; Excitatory Amino Acid Agonists; Fibroblast Growth Factor 2; Gene Expression; Hippocampus; Humans; Interleukin-1; N-Methylaspartate; Nerve Degeneration; Nerve Growth Factors; Neurons; Rats; Rats, Inbred F344; Transforming Growth Factor alpha; Transforming Growth Factor beta | 1996 |
In vivo protection against NMDA-induced neurodegeneration by MK-801 and nimodipine: combined therapy and temporal course of protection.
Topics: Aging; Analysis of Variance; Animals; Brain; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Male; N-Methylaspartate; Nerve Degeneration; Nerve Fibers; Neurons; Nimodipine; Rats; Rats, Wistar | 1996 |
Role of the parafascicular thalamic nucleus and N-methyl-D-aspartate transmission in the D1-dependent control of in vivo acetylcholine release in rat striatum.
Topics: Acetylcholine; Animals; Benzazepines; Dextroamphetamine; Dizocilpine Maleate; Dopamine Agonists; Dopamine Antagonists; Dopamine Uptake Inhibitors; Excitatory Amino Acid Antagonists; Male; Microdialysis; N-Methylaspartate; Neostriatum; Nerve Degeneration; Neurons, Afferent; Prefrontal Cortex; Rats; Rats, Inbred Strains; Receptors, Dopamine D1; Receptors, N-Methyl-D-Aspartate; Remoxipride; Synaptic Transmission; Thalamic Nuclei | 1996 |
Activation of group III metabotropic glutamate receptors is neuroprotective in cortical cultures.
Topics: Alanine; Animals; Cells, Cultured; Cerebral Cortex; Mice; N-Methylaspartate; Nerve Degeneration; Neurons; Phenylalanine; Rabbits; Receptors, Metabotropic Glutamate | 1996 |
Dextromethorphan reduces functional deficits and neuronal damage after global ischemia in rats.
Topics: Animals; Behavior, Animal; Brain Ischemia; Dextromethorphan; Male; Maze Learning; Memory; Motor Activity; N-Methylaspartate; Nerve Degeneration; Neurons; Neuroprotective Agents; Rats; Rats, Wistar | 1996 |
Dual mode of N-methyl-D-aspartate-induced neuronal death in hippocampal slice cultures in relation to N-methyl-D-aspartate receptor properties.
Topics: Animals; Cell Death; Cell Membrane; Electrophysiology; Excitatory Amino Acid Agonists; Hippocampus; In Vitro Techniques; Magnesium; N-Methylaspartate; Nerve Degeneration; Neurons; Patch-Clamp Techniques; Propidium; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1997 |
Quantitative analysis of microglial reaction to a cortical excitotoxic lesion in the early postnatal brain.
Topics: Animals; Animals, Suckling; Excitatory Amino Acid Agonists; Hippocampus; Image Processing, Computer-Assisted; Injections; Lectins; Microglia; Motor Cortex; N-Methylaspartate; Nerve Degeneration; Plant Lectins; Rats; Somatosensory Cortex; Thalamus; Time Factors | 1997 |
Effect of corticosterone and adrenalectomy on NMDA-induced cholinergic cell death in rat magnocellular nucleus basalis.
Topics: Acetylcholinesterase; Adrenalectomy; Animals; Astrocytes; Cell Death; Cholinergic Fibers; Corticosterone; Glial Fibrillary Acidic Protein; Immunohistochemistry; Male; N-Methylaspartate; Nerve Degeneration; Rats; Rats, Wistar; Substantia Innominata | 1997 |
Opposing regulation of tau protein levels by ionotropic and metabotropic glutamate receptors in human NT2 neurons.
Topics: Cell Death; Cell Line; Cycloleucine; Excitatory Amino Acid Agonists; Gene Expression; Humans; N-Methylaspartate; Nerve Degeneration; Neurons; Neuroprotective Agents; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; tau Proteins | 1998 |
Basolateral amygdala lesions block the disruptive effects of long-term adrenalectomy on spatial memory.
Topics: Adrenalectomy; Amygdala; Analysis of Variance; Animals; Corticosterone; Dentate Gyrus; Male; Maze Learning; Memory; N-Methylaspartate; Nerve Degeneration; Rats; Rats, Sprague-Dawley; Space Perception; Weight Gain | 1998 |
Neurodegeneration induced by reversed microdialysis of NMDA; a quantitative model for excitotoxicity in vivo.
Topics: 2-Amino-5-phosphonovalerate; Animals; Corpus Striatum; Drug Combinations; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Magnesium; Male; Microdialysis; N-Methylaspartate; Necrosis; Nerve Degeneration; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Somatosensory Cortex | 1998 |
Excitatory amino acid-induced degeneration of dendrites of catecholamine neurons in rat substantia nigra.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Catecholamines; Dendrites; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Kainic Acid; Male; N-Methylaspartate; Nerve Degeneration; Neurotoxins; Organ Culture Techniques; Rats; Rats, Sprague-Dawley; Substantia Nigra | 1998 |
Intraspinal injection of adenosine agonists protect against L-NAME induced neuronal loss in the rat.
Topics: Adenosine; Animals; Disease Models, Animal; Drug Interactions; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Injections, Spinal; Male; N-Methylaspartate; Nerve Degeneration; Neuroprotective Agents; NG-Nitroarginine Methyl Ester; Purinergic P1 Receptor Agonists; Purinergic P2 Receptor Agonists; Rats; Rats, Long-Evans; Spinal Cord | 1998 |
Selective activation of group-II metabotropic glutamate receptors is protective against excitotoxic neuronal death.
Topics: Animals; Cells, Cultured; Cerebral Cortex; Excitatory Amino Acid Agonists; Mice; N-Methylaspartate; Nerve Degeneration; Proline; Receptors, Metabotropic Glutamate | 1998 |
Differential blood-brain barrier breakdown and leucocyte recruitment following excitotoxic lesions in juvenile and adult rats.
Topics: Aging; Animals; Astrocytes; Biomarkers; Blood-Brain Barrier; Brain; Excitatory Amino Acid Agonists; Immunoenzyme Techniques; Inflammation; Kainic Acid; Leukocytes; Male; Microglia; N-Methylaspartate; Nerve Degeneration; Permeability; Rats; Rats, Wistar; Time Factors | 1998 |
In vitro evidence for increased facilitation of striatal acetylcholine release via pre- and postsynaptic NMDA receptors in hemiparkinsonian rats.
Topics: Acetylcholine; Animals; Corpus Striatum; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Male; N-Methylaspartate; Nerve Degeneration; Organ Culture Techniques; Oxidopamine; Parkinson Disease, Secondary; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sympatholytics; Synaptosomes | 1999 |
The effects of NMDA-induced retrohippocampal lesions on performance of four spatial memory tasks known to be sensitive to hippocampal damage in the rat.
Topics: Animals; Entorhinal Cortex; Excitatory Amino Acid Agonists; Hippocampus; Male; Maze Learning; Memory; N-Methylaspartate; Nerve Degeneration; Neurons; Neurotoxins; Rats; Rats, Inbred Strains; Space Perception | 1999 |
N-Methyl-D-aspartate antagonists and apoptotic cell death triggered by head trauma in developing rat brain.
Topics: Animals; Apoptosis; Brain; Brain Injuries; Caudate Nucleus; Disease Models, Animal; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Frontal Lobe; Gyrus Cinguli; In Situ Nick-End Labeling; N-Methylaspartate; Nerve Degeneration; Parietal Lobe; Piperazines; Rats; Rats, Wistar; Thalamus; Time Factors | 1999 |
Neurotoxic N-methyl-D-aspartate lesion of the ventral midbrain and mesopontine junction alters sleep-wake organization.
Topics: Animals; Brain Mapping; Brain Stem; Cats; Electroencephalography; Electromyography; Electrooculography; Female; Male; Mesencephalon; Motor Activity; N-Methylaspartate; Nerve Degeneration; Neurons; Neurotoxins; Organ Specificity; Pons; Prosencephalon; Sleep; Sleep, REM; Wakefulness | 1999 |
Ascorbic acid is neuroprotective against global ischaemia in striatum but not hippocampus: histological and voltammetric data.
Topics: Alkylating Agents; Animals; Ascorbic Acid; Brain Ischemia; Corpus Striatum; Dopamine; Drug Interactions; Electrochemistry; Ethylmaleimide; Gerbillinae; Hippocampus; Male; N-Methylaspartate; Nerve Degeneration; Neuroprotective Agents; Rats; Rats, Wistar | 1999 |
NMDA and non-NMDA receptor-mediated excitotoxicity are potentiated in cultured striatal neurons by prior chronic depolarization.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Benzodiazepines; Calcium; Cells, Cultured; Corpus Striatum; Cycloleucine; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Female; Fetus; GluK2 Kainate Receptor; GluK3 Kainate Receptor; Kainic Acid; Membrane Potentials; N-Methylaspartate; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Potassium Chloride; Pregnancy; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate | 1999 |
Ischaemic pre-conditioning in organotypic hippocampal slice cultures is inversely correlated to the induction of the 72 kDa heat shock protein (HSP72).
Topics: Animals; Brain Ischemia; Excitatory Amino Acid Agonists; Glutamic Acid; Heat-Shock Proteins; Hippocampus; HSP72 Heat-Shock Proteins; Ischemic Preconditioning; Kainic Acid; N-Methylaspartate; Nerve Degeneration; Neurotoxins; Organ Culture Techniques; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 1999 |
Opposing effects of excitatory amino acids on chick embryo spinal cord motoneurons: excitotoxic degeneration or prevention of programmed cell death.
Topics: Animals; Apoptosis; Chick Embryo; Down-Regulation; Drug Tolerance; Excitatory Amino Acid Agonists; Motor Neurons; N-Methylaspartate; Necrosis; Nerve Degeneration; Neurotoxins; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Time Factors | 1999 |
Nuclear factor kappa B-mediated kainate neurotoxicity in the rat and hamster hippocampus.
Topics: Animals; Cell Death; Cell Nucleus; Cricetinae; Dizocilpine Maleate; Epilepsy; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Hippocampus; Kainic Acid; Mesocricetus; N-Methylaspartate; Nerve Degeneration; Neurons; Neurotoxins; NF-kappa B; Rats; Rats, Sprague-Dawley | 1999 |
Neuroprotective actions of novel and potent ligands of group I and group II metabotropic glutamate receptors.
Topics: Animals; Benzoates; Bridged Bicyclo Compounds; Cells, Cultured; Cerebral Cortex; Drug Evaluation, Preclinical; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Gerbillinae; Glycine; Ischemia; Male; N-Methylaspartate; Nerve Degeneration; Neurons; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Thiophenes | 1999 |
Neuroprotection by metabotropic glutamate receptor agonists on kainate-induced degeneration of motor neurons in spinal cord slices from adult rat.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Benzoates; Cell Survival; Choline O-Acetyltransferase; Cycloleucine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; In Situ Nick-End Labeling; In Vitro Techniques; Kainic Acid; Male; Motor Neurons; N-Methylaspartate; Nerve Degeneration; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Spinal Cord | 2000 |
Differential vulnerabilities of substantia nigra catecholamine neurons to excitatory amino acid-induced degeneration in rat midbrain slices.
Topics: Animals; Catecholamines; Cell Death; Dendrites; Excitatory Amino Acid Agonists; Kainic Acid; Male; N-Methylaspartate; Nerve Degeneration; Neurons; Organ Culture Techniques; Rats; Rats, Sprague-Dawley; Substantia Nigra; Tyrosine 3-Monooxygenase | 2000 |
Rats with hippocampal damage are impaired on place learning in the water task when overtrained under constrained conditions.
Topics: Animals; Conditioning, Psychological; Escape Reaction; Excitatory Amino Acid Agonists; Hippocampus; Male; Maze Learning; Movement; N-Methylaspartate; Nerve Degeneration; Photic Stimulation; Rats; Rats, Long-Evans; Space Perception; Swimming; Water | 2000 |
Intracellular glutathione levels determine cerebellar granule neuron sensitivity to excitotoxic injury by kainic acid.
Topics: Animals; Cell Survival; Cerebellum; Excitatory Amino Acid Agonists; Fluoresceins; Glutamic Acid; Glutathione; Kainic Acid; N-Methylaspartate; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Oxidative Stress; Radiation-Protective Agents; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species | 2000 |
Caspase-mediated degradation of AMPA receptor subunits: a mechanism for preventing excitotoxic necrosis and ensuring apoptosis.
Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Calcium; Caspases; Cell Survival; Cells, Cultured; Excitatory Amino Acid Agonists; Fluorescent Antibody Technique; Glutamic Acid; Hippocampus; N-Methylaspartate; Necrosis; Neocortex; Nerve Degeneration; Nerve Growth Factors; Neurons; Neuroprotective Agents; Neurotoxins; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Synaptosomes | 2000 |
Chronic corticosterone administration dose-dependently modulates Abeta(1-42)- and NMDA-induced neurodegeneration in rat magnocellular nucleus basalis.
Topics: Amyloid beta-Peptides; Animals; Basal Nucleus of Meynert; Corticosterone; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Male; N-Methylaspartate; Nerve Degeneration; Neuroprotective Agents; Peptide Fragments; Rats; Rats, Wistar; Time Factors | 2000 |
Human rotation-mediated fetal mixed brain cell aggregate culture: characterization and N-methyl-D-aspartate toxicity.
Topics: Astrocytes; Brain; Cell Culture Techniques; Cell Separation; Cells, Cultured; Excitatory Amino Acid Agonists; Fetus; Humans; L-Lactate Dehydrogenase; Microscopy, Confocal; N-Methylaspartate; Nerve Degeneration; Neurons; Phosphopyruvate Hydratase; Rotation | 2000 |
Selective activation of mGlu4 metabotropic glutamate receptors is protective against excitotoxic neuronal death.
Topics: Aminobutyrates; Animals; Cells, Cultured; Cerebral Cortex; Excitatory Amino Acid Agonists; Glutamic Acid; Glycine; Heterozygote; Mice; Mice, Knockout; N-Methylaspartate; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Receptors, Metabotropic Glutamate; Stereoisomerism | 2000 |
Selective blockade of metabotropic glutamate receptor subtype 5 is neuroprotective.
Topics: Amyloid beta-Peptides; Animals; Cells, Cultured; Cerebral Cortex; Excitatory Amino Acid Antagonists; Male; Mice; N-Methylaspartate; Nerve Degeneration; Neuroglia; Neurons; Neuroprotective Agents; Phenazopyridine; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate | 2000 |
p53 and Bax implication in NMDA induced-apoptosis in mouse hippocampus.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; DNA Fragmentation; Hippocampus; Mice; Mice, Knockout; N-Methylaspartate; Nerve Degeneration; Neurons; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Tumor Suppressor Protein p53 | 2000 |
Neuronal, astroglial and microglial cytokine expression after an excitotoxic lesion in the immature rat brain.
Topics: Age Factors; Animals; Animals, Newborn; Astrocytes; Brain Injuries; Cytokines; Gene Expression Regulation, Developmental; Interleukin-1; Interleukin-6; Microglia; N-Methylaspartate; Neocortex; Nerve Degeneration; Neurons; Rats; Rats, Long-Evans; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha | 2000 |
Increased amyloid precursor protein expression and serotonergic sprouting following excitotoxic lesion of the rat magnocellular nucleus basalis: neuroprotection by Ca(2+) antagonist nimodipine.
Topics: Amyloid beta-Protein Precursor; Animals; Axons; Basal Nucleus of Meynert; Calcium Channels, L-Type; Choline O-Acetyltransferase; Denervation; Male; Maze Learning; N-Methylaspartate; Nerve Degeneration; Nerve Regeneration; Neural Pathways; Neuronal Plasticity; Neuroprotective Agents; Neurotoxins; Nimodipine; Rats; Rats, Wistar; Serotonin | 2000 |
Presenilin-1 regulates the neuronal threshold to excitotoxicity both physiologically and pathologically.
Topics: Alzheimer Disease; Animals; Brain; Cells, Cultured; Disease Models, Animal; Excitatory Amino Acid Agonists; Gene Expression; Humans; Infarction, Middle Cerebral Artery; Kainic Acid; Membrane Proteins; Mice; Mice, Knockout; Mice, Transgenic; N-Methylaspartate; Nerve Degeneration; Neurons; Presenilin-1 | 2000 |
Neuroprotective effects of brain-derived neurotrophic factor in eyes with NMDA-induced neuronal death.
Topics: Animals; Brain-Derived Neurotrophic Factor; Cell Count; Cell Death; Fluorescent Dyes; Glutamic Acid; Male; N-Methylaspartate; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Retina; Retinal Ganglion Cells; Stilbamidines; Vitreous Body | 2000 |
Excitotoxic lesions of the medial amygdala differentially disrupt prolactin secretory responses in cycling and mated female rats.
Topics: Amygdala; Animals; Copulation; Estrus; Excitatory Amino Acid Agonists; Female; Follicular Phase; N-Methylaspartate; Nerve Degeneration; Neurotoxins; Posture; Progesterone; Prolactin; Radioimmunoassay; Rats; Rats, Long-Evans | 2001 |
Chronic nicotine exposure reduces N-methyl-D-aspartate receptor-mediated damage in the hippocampus without altering calcium accumulation or extrusion: evidence of calbindin-D28K overexpression.
Topics: Animals; Autoradiography; Calbindin 1; Calbindins; Calcium; Calcium Radioisotopes; Cell Death; Dose-Response Relationship, Drug; Drug Administration Schedule; Hippocampus; Immunohistochemistry; N-Methylaspartate; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Nicotine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; S100 Calcium Binding Protein G | 2001 |
Effect of amyloid beta peptide on poly(ADP-ribose) polymerase activity in adult and aged rat hippocampus.
Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Animals; Cerebral Cortex; DNA Damage; Free Radicals; Hippocampus; Humans; N-Methylaspartate; Nerve Degeneration; Nitric Oxide; Peptide Fragments; Poly(ADP-ribose) Polymerases; Rats; Rats, Wistar | 2000 |
Neuronal injury-induced expression and release of apolipoprotein E in mixed neuron/glia co-cultures: nuclear factor kappaB inhibitors reduce basal and lesion-induced secretion of apolipoprotein E.
Topics: Alzheimer Disease; Animals; Antibodies; Apolipoproteins E; Cell Death; Cell Division; Cells, Cultured; Coculture Techniques; Dose-Response Relationship, Drug; Embryo, Mammalian; Excitatory Amino Acid Agonists; Glial Fibrillary Acidic Protein; Models, Animal; N-Methylaspartate; Nerve Degeneration; Neuroglia; Neurons; NF-kappa B; Rats; Rats, Sprague-Dawley; RNA, Messenger; Synaptophysin; Time Factors; Up-Regulation | 2001 |
An activity-dependent switch from facilitation to inhibition in the control of excitotoxicity by group I metabotropic glutamate receptors.
Topics: Animals; Cells, Cultured; Cerebral Cortex; Enzyme Activation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Mice; N-Methylaspartate; Nerve Degeneration; Neural Inhibition; Neuroprotective Agents; Neurotoxins; Protein Kinase C; Quisqualic Acid; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Resorcinols; Time Factors | 2001 |
Interleukin-1beta exacerbates hypoxia-induced neuronal damage, but attenuates toxicity produced by simulated ischaemia and excitotoxicity in rat organotypic hippocampal slice cultures.
Topics: Animals; Brain Ischemia; Culture Techniques; Dose-Response Relationship, Drug; Glucose; Hippocampus; Hypoxia; Interleukin 1 Receptor Antagonist Protein; Interleukin-1; N-Methylaspartate; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Osmolar Concentration; Rats; Rats, Wistar; Sialoglycoproteins | 2001 |
Dual effects of interleukin-1beta on N-methyl-D-aspartate-induced retinal neuronal death in rat eyes.
Topics: Animals; Cell Death; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Excitatory Amino Acid Agonists; Eye Diseases; Glutamic Acid; Immunohistochemistry; Interleukin 1 Receptor Antagonist Protein; Interleukin-1; Male; N-Methylaspartate; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Retina; Sialoglycoproteins; Up-Regulation | 2001 |
Dependence of excitotoxic neurodegeneration on mitochondrial aconitase inactivation.
Topics: Aconitate Hydratase; Animals; Astrocytes; Cell Death; Cell Fractionation; Cells, Cultured; Enzyme Inhibitors; Fumarate Hydratase; Glucose; Kainic Acid; Metalloporphyrins; Mitochondria; N-Methylaspartate; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Oxygen; Paraquat; Rats; Superoxides | 2001 |
Astrocytic factors protect neuronal integrity and reduce microglial activation in an in vitro model of N-methyl-D-aspartate-induced excitotoxic injury in organotypic hippocampal slice cultures.
Topics: Animals; Astrocytes; Brain Injuries; Cell Communication; Cell Death; Cell Size; Cells, Cultured; Culture Media, Conditioned; Dentate Gyrus; Disease Models, Animal; Down-Regulation; Excitatory Amino Acid Agonists; Fluorescein-5-isothiocyanate; Gliosis; Growth Substances; Hippocampus; Lectins; Microglia; Microscopy, Confocal; N-Methylaspartate; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Rats; Rats, Wistar; Transforming Growth Factor beta | 2001 |
Disrupting basolateral amygdala function impairs unconditioned freezing and avoidance in rats.
Topics: Amygdala; Anesthetics, Local; Animals; Avoidance Learning; Behavior, Animal; Conditioning, Psychological; Denervation; Excitatory Amino Acid Agonists; Fear; Lidocaine; Male; N-Methylaspartate; Nerve Degeneration; Neural Pathways; Neurons; Neurotoxins; Rats; Rats, Sprague-Dawley | 2001 |
Anandamide, but not 2-arachidonoylglycerol, accumulates during in vivo neurodegeneration.
Topics: Animals; Arachidonic Acids; Brain Concussion; Cannabinoid Receptor Modulators; Cerebral Cortex; Corpus Striatum; Craniocerebral Trauma; Dizocilpine Maleate; Endocannabinoids; Ethanolamines; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycerides; Male; N-Methylaspartate; Nerve Degeneration; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; RNA, Messenger | 2001 |
Short-term consequences of N-methyl-D-aspartate excitotoxicity in rat magnocellular nucleus basalis: effects on in vivo labelling of cholinergic neurons.
Topics: Acetylcholine; Animals; Basal Nucleus of Meynert; Carbocyanines; Choline O-Acetyltransferase; Excitatory Amino Acid Agonists; Fluoresceins; Fluorescent Dyes; Immunoglobulin G; Immunohistochemistry; Injections, Intraventricular; Male; Microscopy, Confocal; N-Methylaspartate; Nerve Degeneration; Neural Pathways; Neuroglia; Neurons; Neurotoxins; Organic Chemicals; Rats; Rats, Wistar; Receptor, Nerve Growth Factor; Receptors, N-Methyl-D-Aspartate; Sensitivity and Specificity | 2001 |
Regulation of microglial expression of integrins by poly(ADP-ribose) polymerase-1.
Topics: Animals; Brain Diseases; Cell Movement; Cells, Cultured; DNA, Antisense; Excitatory Amino Acid Agonists; Gene Expression; Lymphocyte Function-Associated Antigen-1; Mice; Microglia; N-Methylaspartate; Nerve Degeneration; Neurotoxins; NF-kappa B; Phagocytosis; Poly(ADP-ribose) Polymerases; RNA, Messenger; Transfection | 2001 |
Glial expression of small heat shock proteins following an excitotoxic lesion in the immature rat brain.
Topics: Aging; Animals; Astrocytes; Brain; Brain Injuries; Cerebral Cortex; Female; Glial Fibrillary Acidic Protein; Gliosis; Heat-Shock Proteins; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; HSP27 Heat-Shock Proteins; HSP47 Heat-Shock Proteins; Macrophages; Male; Microglia; N-Methylaspartate; Neoplasm Proteins; Nerve Degeneration; Neuroglia; Rats; Rats, Long-Evans; Stress, Physiological; Thalamus; Up-Regulation | 2002 |
Arctigenin protects cultured cortical neurons from glutamate-induced neurodegeneration by binding to kainate receptor.
Topics: Animals; Cells, Cultured; Cerebral Cortex; Free Radical Scavengers; Furans; Glutamic Acid; Kainic Acid; Lignans; N-Methylaspartate; Nerve Degeneration; Neurons; Neuroprotective Agents; Peroxides; Rats; Rats, Sprague-Dawley; Receptors, Kainic Acid | 2002 |
Metabotropic glutamate receptors and neuronal toxicity.
Topics: Amino Acids, Diamino; Animals; Cells, Cultured; Cerebellum; Cyanobacteria Toxins; Cycloleucine; N-Methylaspartate; Nerve Degeneration; Neurons; Neurotoxins; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1992 |
Synaptic and nonsynaptic determinants of excitability changes in aluminum-intoxicated rabbit CA1 pyramidal neurons studied in vitro.
Topics: Aluminum; Aluminum Chloride; Aluminum Compounds; Animals; Chlorides; Culture Techniques; Dose-Response Relationship, Drug; Evoked Potentials; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Hippocampus; N-Methylaspartate; Nerve Degeneration; Neurofibrils; Neurons; Rabbits; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission | 1992 |
Pre-synaptic dopaminergic control mechanisms for CCK-8 like immunoreactivity in the rat medial frontal cortex.
Topics: Animals; Apomorphine; Behavior, Animal; Cholecystokinin; Dopamine; Dopamine Agents; In Vitro Techniques; Male; Microinjections; N-Methylaspartate; Nerve Degeneration; Neurons; Piperidines; Prefrontal Cortex; Rats; Rats, Wistar; Receptors, Dopamine | 1992 |
Neuronal loss or replacement in the injured adult cerebral neocortex induces extensive remodeling of intrinsic and afferent neural systems.
Topics: Afferent Pathways; Analysis of Variance; Animals; Axonal Transport; Cerebral Cortex; Choline O-Acetyltransferase; Female; Glutamate Decarboxylase; Glutamates; Glutamic Acid; Kainic Acid; N-Methylaspartate; Nerve Degeneration; Nerve Regeneration; Neurons; Neurotoxins; Norepinephrine; Rats; Rats, Inbred Strains; Serotonin; Sympathectomy | 1992 |
NMDA antagonist activity of (+/-)-(2SR,4RS)-4-(1H-tetrazol-5-ylmethyl)piperidine-2-carboxylic acid resides with the (-)-2R,4S-isomer.
Topics: Animals; Animals, Newborn; Corpus Striatum; Mice; Molecular Structure; N-Methylaspartate; Nerve Degeneration; Pipecolic Acids; Rats; Receptors, N-Methyl-D-Aspartate; Seizures; Stereoisomerism; Structure-Activity Relationship; Tetrazoles; X-Ray Diffraction | 1992 |
Protective effect of the NMDA antagonist MK-801 on photochemically induced spinal lesions in the rat.
Topics: Animals; Behavior, Animal; Dizocilpine Maleate; Female; Glial Fibrillary Acidic Protein; Immunohistochemistry; Ischemia; Lasers; N-Methylaspartate; Nerve Degeneration; Neurofilament Proteins; Radiation Injuries, Experimental; Rats; Rats, Sprague-Dawley; Spinal Cord | 1992 |
Nitric oxide inhibitors attenuate N-methyl-D-aspartate excitotoxicity in rat hippocampal slices.
Topics: Animals; Arginine; Calcium; Hemoglobins; Hippocampus; In Vitro Techniques; N-Methylaspartate; Nerve Degeneration; Nitric Oxide; Nitroarginine; omega-N-Methylarginine; Rats; Synapses | 1992 |
Increased NMDA responses and dendritic degeneration in human epileptic hippocampal neurons in slices.
Topics: Adolescent; Adult; Dendrites; Electric Stimulation; Epilepsy; Hippocampus; Humans; N-Methylaspartate; Nerve Degeneration; Neurons; Synapses; Synaptic Transmission | 1991 |
A metabotropic glutamate receptor agonist does not mediate neuronal degeneration in cortical culture.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cells, Cultured; Cerebral Cortex; Cycloleucine; Embryo, Mammalian; Glutamates; Ibotenic Acid; Kainic Acid; L-Lactate Dehydrogenase; Mice; N-Methylaspartate; Nerve Degeneration; Neurons; Neurotoxins; Receptors, Glutamate; Receptors, Neurotransmitter; Tetrodotoxin | 1991 |
The inhibition of glutamine synthetase in rat corpus striatum in vitro by methionine sulfoximine increases the neurotoxic effects of kainate and N-methyl-D-aspartate.
Topics: Animals; Cerebellum; Corpus Striatum; Drug Synergism; Female; Glutamate-Ammonia Ligase; Kainic Acid; Methionine Sulfoximine; N-Methylaspartate; Nerve Degeneration; Nervous System Diseases; Neuroglia; Phosphopyruvate Hydratase; Rats; Rats, Inbred Strains | 1991 |
Excitotoxicity in the embryonic chick spinal cord.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids, Diamino; Animals; beta-Alanine; Chick Embryo; Cyanobacteria Toxins; Dizocilpine Maleate; Glutamates; Glutamic Acid; Ibotenic Acid; Kainic Acid; Motor Neurons; N-Methylaspartate; Nerve Degeneration; Neurotoxins; Quinoxalines; Quisqualic Acid; Spinal Cord | 1991 |
Non-NMDA antagonists protect against kainate more than AMPA toxicity in the rat hippocampus.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Benzodiazepines; Hippocampus; Ibotenic Acid; Kainic Acid; Male; N-Methylaspartate; Nerve Degeneration; Neurons; Neurotoxins; Pyramidal Tracts; Quinoxalines; Rats; Rats, Inbred Strains | 1991 |
Neuroprotectant effects of LY274614, a structurally novel systemically active competitive NMDA receptor antagonist.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Binding, Competitive; Brain; Dose-Response Relationship, Drug; Female; Ibotenic Acid; Isoquinolines; Kainic Acid; Male; N-Methylaspartate; Nerve Degeneration; Quisqualic Acid; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 1991 |
Cerebral ischemia decreases the behavioral effects and mortality rate elicited by activation of NMDA receptors in mice.
Topics: Animals; Behavior, Animal; Carbon Dioxide; Dizocilpine Maleate; Female; Hypoxia; Injections, Intraventricular; Ischemic Attack, Transient; Mice; Mice, Inbred Strains; N-Methylaspartate; Nerve Degeneration; Pentylenetetrazole; Receptors, N-Methyl-D-Aspartate; Survival Rate | 1991 |
Cortical neurons containing somatostatin- or parvalbumin-like immunoreactivity are atypically vulnerable to excitotoxic injury in vitro.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Cell Survival; Cells, Cultured; Cerebral Cortex; Fetus; Ibotenic Acid; Kainic Acid; L-Lactate Dehydrogenase; Mice; Muscle Proteins; N-Methylaspartate; Nerve Degeneration; Neurons; Neurotoxins; Oxazoles; Parvalbumins; Somatostatin | 1990 |
Dual effect of glycine on NMDA-induced neurotoxicity in rat cortical cultures.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cells, Cultured; Cerebral Cortex; Drug Synergism; gamma-Aminobutyric Acid; Glycine; Kynurenic Acid; L-Lactate Dehydrogenase; N-Methylaspartate; Nerve Degeneration; Neurons; Oocytes; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Taurine; Xenopus | 1990 |
21-Aminosteroids attenuate excitotoxic neuronal injury in cortical cell cultures.
Topics: Animals; Aspartic Acid; Cells, Cultured; Cerebral Cortex; Glucose; Lipid Peroxidation; Lipid Peroxides; Membrane Potentials; Mice; N-Methylaspartate; Nerve Degeneration; Neurons; Pregnatrienes; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
Transneuronal degeneration in the midbrain central gray following chemical lesions in the ventromedial nucleus: a qualitative and quantitative analysis.
Topics: Animals; Cerebral Cortex; Female; Kainic Acid; Mesencephalon; N-Methylaspartate; Nerve Degeneration; Neurons; Parietal Lobe; Periaqueductal Gray; Rats; Rats, Inbred Strains; Synapses; Ventromedial Hypothalamic Nucleus | 1990 |
Kainic acid on neostriatal neurons intracellularly recorded in vitro: electrophysiological evidence for differential neuronal sensitivity.
Topics: Action Potentials; Animals; Cell Membrane; Corpus Striatum; Dose-Response Relationship, Drug; In Vitro Techniques; Kainic Acid; Kynurenic Acid; Male; Membrane Potentials; N-Methylaspartate; Nerve Degeneration; Neural Conduction; Neurons; Quisqualic Acid; Rats; Rats, Inbred Strains | 1990 |
CGS-19755 and MK-801 selectively prevent rat striatal cholinergic and gabaergic neuronal degeneration induced by N-methyl-D-aspartate and ibotenate in vivo.
Topics: Animals; Aspartic Acid; Choline O-Acetyltransferase; Cholinergic Fibers; Corpus Striatum; Dibenzocycloheptenes; Dizocilpine Maleate; gamma-Aminobutyric Acid; Ibotenic Acid; Male; N-Methylaspartate; Nerve Degeneration; Oxazoles; Pipecolic Acids; Piperidines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
Sensitivity of the developing rat brain to hypobaric/ischemic damage parallels sensitivity to N-methyl-aspartate neurotoxicity.
Topics: Air Pressure; Animals; Animals, Newborn; Aspartic Acid; Atmospheric Pressure; Brain; Brain Ischemia; Disease Susceptibility; Microinjections; N-Methylaspartate; Nerve Degeneration; Neurons; Rats; Rats, Inbred Strains | 1989 |
Comparison of behavioral effects of nucleus basalis magnocellularis lesions and somatosensory cortex ablation in the rat.
Topics: Animals; Aspartic Acid; Basal Ganglia; Behavior, Animal; Cholinergic Fibers; Discrimination Learning; Emotions; Male; Memory; N-Methylaspartate; Nerve Degeneration; Rats; Rats, Inbred Strains; Somatosensory Cortex | 1989 |
Excitatory aminoacid antagonists provide a therapeutic approach to neurological disorders.
Topics: Adult; Amino Acids; Animals; Aspartic Acid; Brain Diseases; Brain Ischemia; Glutamates; Humans; Hypoxia, Brain; Infant; N-Methylaspartate; Nerve Degeneration; Neurotransmitter Agents; Quinolinic Acids; Receptors, Amino Acid; Receptors, Cell Surface; Seizures | 1985 |
AMPA is a powerful neurotoxin in the chicken retina.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Chickens; Choline O-Acetyltransferase; Dose-Response Relationship, Drug; Ibotenic Acid; Injections; Kainic Acid; N-Methylaspartate; Nerve Degeneration; Oxadiazoles; Oxazoles; Quisqualic Acid; Retina; Retinal Ganglion Cells; Vitreous Body | 1987 |
Peripheral type benzodiazepine binding sites are a sensitive indirect index of neuronal damage.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Binding Sites; Choline O-Acetyltransferase; Corpus Striatum; Glutamate Decarboxylase; Ibotenic Acid; Kainic Acid; Male; N-Methylaspartate; Nerve Degeneration; Neurotoxins; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1987 |
Neuroprotective effects of MK-801 in vivo: selectivity and evidence for delayed degeneration mediated by NMDA receptor activation.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anesthesia; Animals; Aspartic Acid; Brain; Dibenzocycloheptenes; Dizocilpine Maleate; Ibotenic Acid; Isoflurane; Kainic Acid; Male; N-Methylaspartate; Nerve Degeneration; Piperazines; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Time Factors | 1988 |
Quinolinate mimics neurotoxic actions of N-methyl-D-aspartate in rat cerebellar slices.
Topics: Animals; Aspartic Acid; Cerebellum; In Vitro Techniques; N-Methylaspartate; Nerve Degeneration; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats | 1987 |
Excitatory amino acid antagonists as novel anticonvulsants.
Topics: Amino Acids, Dicarboxylic; Animals; Anticonvulsants; Aspartic Acid; Epilepsy; Glutamates; Kainic Acid; N-Methylaspartate; Nerve Degeneration; Nervous System Diseases; Oxadiazoles; Quisqualic Acid; Receptors, Amino Acid; Receptors, Cell Surface; Structure-Activity Relationship | 1986 |
Systemic administration of MK-801 prevents N-methyl-D-aspartate-induced neuronal degeneration in rat brain.
Topics: Animals; Aspartic Acid; Choline O-Acetyltransferase; Corpus Striatum; Dibenzocycloheptenes; Dizocilpine Maleate; Hippocampus; Kainic Acid; Male; N-Methylaspartate; Nerve Degeneration; Rats; Rats, Inbred Strains | 1987 |
Amino acid neurotoxicity: intracellular sites of calcium accumulation associated with the onset of irreversible damage to rat cerebellar neurones in vitro.
Topics: Animals; Aspartic Acid; Calcium; Cell Nucleus; Cerebellum; Golgi Apparatus; In Vitro Techniques; Microscopy, Electron; N-Methylaspartate; Nerve Degeneration; Organoids; Rats | 1986 |