n-methylaspartate has been researched along with Infarction, Middle Cerebral Artery in 51 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 30 (58.82) | 29.6817 |
| 2010's | 18 (35.29) | 24.3611 |
| 2020's | 3 (5.88) | 2.80 |
| Authors | Studies |
|---|---|
| Cheng, J; Lu, L; Lv, Q; Ma, Z; Ren, Q; Wang, K; Wang, X; Zhang, S; Zhao, X | 1 |
| Chao, LC; Huang, CC; Huang, SY; Lee, AH; Lee, EJ; Lin, YW; Shan, YS; Tai, SH; Wu, TS | 1 |
| Alasoadura, M; Chuquet, J; Clarkson, AN; Gach-Janczak, K; Gowing, EK; Hazime, M; Lamtahri, R; Lefranc, B; Lehongre, K; Leprince, J; Mandrup, S; Marcher, AB; Maucotel, J; Nagaraja, RY; Quilichini, PP; Vaudry, D | 1 |
| Attwell, D; Bazargani, N; Jolly, S; Li, H; Pringle, NP; Quiroga, AC; Richardson, WD | 1 |
| Hu, L; Liu, M; Pan, S; Pei, L; Shang, Y; Song, L; Wu, Y; Xian, W; Xiong, W; Yao, S | 1 |
| Cortés-Montero, E; Garzón, J; Onetti, Y; Rodríguez-Muñoz, M; Sánchez-Blázquez, P | 1 |
| Cananzi, SG; Mayhan, WG | 1 |
| Cheng, EY; Fu, WY; Ip, FC; Ip, NY; Liang, Y; Lok, KC; Tong, EP; Ye, WC | 1 |
| Chen, XY; Huang, YJ; Leng, TD; Liu, AL; Ou, YQ; Qiu, PX; Su, XW; Tang, LP; Yan, GM; Yan, M; Yin, W; Zhang, JX; Zhou, SJ | 1 |
| Bianco, F; Biasini, E; Biggi, S; Borsello, T; Cimini, S; di Marino, D; Falleroni, F; Grande, V; Marin, O; Monti, R; Morelli, F; Repetto, IE; Sclip, A; Stravalaci, M; Tomasi, S; Tonna, N; Vercelli, A | 1 |
| Chen, X; Hu, H; Huang, Y; Leng, T; Li, Q; Liu, A; Qiu, P; Su, X; Wang, Y; Xiong, ZG; Yan, G; Yin, W; Zhang, J; Zhou, S; Zhou, Y; Zhu, W | 1 |
| Cai, W; Chen, L; Furuya, K; Li, Z; Sokabe, M; Zhu, Y | 1 |
| Abraini, JH; Chazalviel, L; David, HN; Haelewyn, B; Lecocq, M; Lemaire, M; Risso, JJ; Rouillon, C | 1 |
| Kim, TY; Kim, YH; Kim, YJ; Koh, JY; Lee, JY | 1 |
| Connell, BJ; Saleh, MC; Saleh, TM | 1 |
| Chen, HH; Duquette, PM; Harper, ME; Lewandowski, AJ; Qin, Z; Rai, PS; Schock, SC; Seifert, EL; Thompson, CS; Xu, J | 1 |
| Chow, N; Davis, TP; Guo, H; Singh, I; Thiyagarajan, M; Wang, Y; Zlokovic, BV | 1 |
| Ahmad, AS; Ahmad, M; Doré, S; Maruyama, T; Yun, YT | 1 |
| Chi, OZ; Hunter, C; Liu, X; Weiss, HR | 1 |
| Barrett, T; Chow, N; Deane, R; Fernández, JA; Griffin, JH; Guo, H; Singh, I; Wang, Y; Zlokovic, BV | 1 |
| Furuta, K; Hokamura, K; Ibaraki, K; Maeda, M; Suzuki, M; Thura, M; Umemura, K; Yamamoto, S | 1 |
| Han, PL; Jeong, JY; Kim, HJ; Kim, SW; Lee, JK; Seo, JS; Yoon, SH | 1 |
| Chen, Z; Fan, YY; He, P; Hu, WW; Ohtsu, H; Shen, Y; Yan, HJ; Zhang, JX | 1 |
| David, KK; Dawson, TM; Dawson, VL; Koehler, RC; Li, X; Xu, Z; Yang, ZJ; Zhang, J | 1 |
| Ahmad, AS; Biswal, S; Doré, S; Kensler, TW; Li, RC; Shah, ZA; Yamamoto, M | 1 |
| Culmsee, C; D'Orsi, B; Dolga, AM; Eisel, UL; Kepura, F; Knaus, HG; Nijholt, IM; Plant, T; Plesnila, N; Prehn, JH; Terpolilli, N | 1 |
| Bai, Y; Chen, L; Li, L; Qi, J; Qi, Z; Sun, K; Yang, R; Zhang, Z; Zhou, L | 1 |
| Clarke, PG; Naegele-Tollardo, S; Puyal, J; Vaslin, A | 1 |
| Arbeloa, J; Gottlieb, M; Matute, C; Pérez-Samartín, A | 1 |
| Abraini, JH; Colomb, DG; David, HN; Degoulet, M; Haelewyn, B; Risso, JJ | 1 |
| Daineko, A; Galagudza, M; Juneja, LR; Petrishchev, N; Prosvirnina, M; Shamtsyan, M; Simanenkova, A; Sonin, D; Vlasov, T; Zukhurova, M | 1 |
| Greenberg, DA; Jin, K; Mao, XO; Parmentier-Batteur, S; Xie, L | 1 |
| Benchenane, K; Chuquet, J; MacKenzie, ET; Roussel, S; Toutain, J; Touzani, O | 1 |
| Bogousslavsky, J; Bonny, C; Borsello, T; Clarke, PG; Hirt, L; Repici, M; Schorderet, DF; Vercelli, A | 1 |
| Andrabi, SA; Horn, TF; Sayeed, I; Siemen, D; Wolf, G | 1 |
| Kim, YH; Koh, JY; Yi, JS | 1 |
| Boutin, H; Pinteaux, E; Rothwell, NJ | 1 |
| Han, PL; Kim, JB; Kim, SW; Lee, JK; Lee, MH; Nam, K; Park, JS; Piao, CS; Sig Choi, J; Yu, YM | 1 |
| Fan, Y; Gu, Y; Lu, CZ; Qiao, J; Shi, L; Wang, Y; Xie, J; Yang, GY; Zhao, Y | 1 |
| Ahn, YM; Byun, HY; Cho, JY; Cho, SI; Chung, JM; Gwag, BJ; Im, DS; Kim, KW; Ko, SY; Kwon, HJ; Lee, HU; Lee, JY; Lee, MJ; Lee, YA; Lim, HR; Moon, HS; Noh, JH; Park, SM; Son, SJ; Won, SJ; Yoon, SH; Yun, BS | 1 |
| Pignataro, G; Simon, RP; Xiong, ZG | 1 |
| Ahmad, AS; Ahmad, M; Doré, S; Maruyama, T; Narumiya, S; Zhuang, H | 1 |
| Bae, K; Ban, JY; Cho, SO; Choi, SH; Ju, HS; Kim, JY; Seong, YH; Song, KS | 1 |
| Belayev, L; Busto, R; Ginsberg, MD; Liu, Y; Zhao, W | 1 |
| Ali, C; Buisson, A; Docagne, F; Lesne, S; MacKenzie, ET; Nicole, O; Nouvelot, A; Vivien, D | 1 |
| Barbieri, I; Basudev, H; Brusa, R; Casati, C; Grilli, M; Lozza, G; Ongini, E | 1 |
| Brusa, R; Casarini, M; Diodato, E; Grilli, M; Lozza, G; Memo, M; Ongini, E; Rozmahel, R; St George-Hyslop, P; Uberti, D; Westaway, D | 1 |
| Iadecola, C; Kazama, K; Niwa, K; Ross, ME; Sugimoto, K | 1 |
| Drozda, M; Ferrante, RJ; Friedlander, RM; Gullans, S; Hartley, DM; Kim, BY; Kristal, BS; Li, M; Liu, AS; Ona, V; Przedborski, S; Sarang, S; Stavrovskaya, IG; Wu, DC; Zhu, S | 1 |
| Bomholt, SF; Bonde, C; Dagø, L; Drejer, J; Grønborg, M; Hartz, JB; Meyer, M; Møller, A; Peters, D | 1 |
| Chang, CF; Chiang, YH; Hoffer, J; Morales, M; Wang, Y | 1 |
1 review(s) available for n-methylaspartate and Infarction, Middle Cerebral Artery
| Article | Year |
|---|---|
Protective effects of glial cell line-derived neurotrophic factor in ischemic brain injury.
Topics: Animals; Apoptosis; Brain; Brain Ischemia; Calcitriol; Drosophila Proteins; Fetal Tissue Transplantation; Glial Cell Line-Derived Neurotrophic Factor; Glial Cell Line-Derived Neurotrophic Factor Receptors; Humans; Infarction, Middle Cerebral Artery; N-Methylaspartate; Nerve Growth Factors; Nerve Tissue Proteins; Neurons; Neuroprotective Agents; Nitric Oxide; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ret; Receptor Protein-Tyrosine Kinases | 2002 |
50 other study(ies) available for n-methylaspartate and Infarction, Middle Cerebral Artery
| Article | Year |
|---|---|
Evaluation of crossed cerebellar diaschisis after cerebral infarction in MCAO rats based on DKI.
Topics: Animals; Apoptosis; Cerebellar Diseases; Cerebral Infarction; Diaschisis; Diffusion Tensor Imaging; Disease Models, Animal; Infarction, Middle Cerebral Artery; Male; N-Methylaspartate; Random Allocation; Rats; Rats, Sprague-Dawley | 2022 |
Lithium upregulates growth-associated protein-43 (GAP-43) and postsynaptic density-95 (PSD-95) in cultured neurons exposed to oxygen-glucose deprivation and improves electrophysiological outcomes in rats subjected to transient focal cerebral ischemia foll
Topics: Animals; Brain Ischemia; Brain-Derived Neurotrophic Factor; Disks Large Homolog 4 Protein; Edetic Acid; GAP-43 Protein; Glucose; Glycogen Synthase Kinase 3 beta; Infarction, Middle Cerebral Artery; Lithium; Lithium Chloride; Male; N-Methylaspartate; Neurons; Neuroprotective Agents; Oxygen; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sodium Dodecyl Sulfate | 2022 |
The Gliopeptide ODN, a Ligand for the Benzodiazepine Site of GABA
Topics: Adult; Animals; Astrocytes; Cortical Spreading Depression; Diazepam Binding Inhibitor; Drug Implants; Evoked Potentials, Somatosensory; Female; GABA-A Receptor Agonists; Humans; Hydrogels; Infarction, Middle Cerebral Artery; Intracranial Thrombosis; Light; Mice; Mice, Inbred C57BL; N-Methylaspartate; Neurons; Neuropeptides; Patch-Clamp Techniques; Peptide Fragments; Rats; Receptors, GABA-A; Rose Bengal; Single-Blind Method; Stroke | 2021 |
G protein-coupled receptor 37-like 1 modulates astrocyte glutamate transporters and neuronal NMDA receptors and is neuroprotective in ischemia.
Topics: Action Potentials; Amino Acid Transport System X-AG; Animals; Animals, Newborn; Aspartic Acid; Astrocytes; Brain; Disease Models, Animal; Exploratory Behavior; Gene Expression Regulation, Developmental; Hippocampus; Infarction, Middle Cerebral Artery; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; N-Methylaspartate; Neurons; Receptors, G-Protein-Coupled; Receptors, N-Methyl-D-Aspartate; Recognition, Psychology | 2018 |
DAPK1-ERK signal mediates oxygen glucose deprivation reperfusion induced apoptosis in mouse N2a cells.
Topics: Animals; Apoptosis; Cell Line, Tumor; Cerebral Cortex; Cytarabine; Death-Associated Protein Kinases; Disease Models, Animal; Excitatory Amino Acid Agonists; Glucose; Glycine; Hypoxia; Immunosuppressive Agents; Infarction, Middle Cerebral Artery; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; N-Methylaspartate; Neuroblastoma; Neurons; Protein Biosynthesis; RNA, Small Interfering | 2018 |
Cannabidiol enhances morphine antinociception, diminishes NMDA-mediated seizures and reduces stroke damage via the sigma 1 receptor.
Topics: Animals; Anticonvulsants; Cannabidiol; Disease Models, Animal; Infarction, Middle Cerebral Artery; Male; Mice, Knockout; Morphine; N-Methylaspartate; Nociception; Protein Subunits; Receptors, N-Methyl-D-Aspartate; Receptors, sigma; Seizures; Sigma-1 Receptor; Stroke | 2018 |
In Utero Exposure to Alcohol Impairs Reactivity of Cerebral Arterioles and Increases Susceptibility of the Brain to Damage Following Ischemia/Reperfusion in Adulthood.
Topics: Acetophenones; Adenosine Diphosphate; Animals; Arterioles; Brain; Enzyme Inhibitors; Ethanol; Excitatory Amino Acid Agonists; Female; Infarction; Infarction, Middle Cerebral Artery; Male; N-Methylaspartate; Nitroglycerin; omega-N-Methylarginine; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Reperfusion Injury | 2019 |
Anemoside A3 Enhances Cognition through the Regulation of Synaptic Function and Neuroprotection.
Topics: Animals; Cognition; Disease Models, Animal; Escape Reaction; Excitatory Postsynaptic Potentials; Exploratory Behavior; Hippocampus; In Vitro Techniques; Infarction, Middle Cerebral Artery; MAP Kinase Signaling System; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; N-Methylaspartate; Nerve Net; Neuroprotective Agents; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Saponins; Spatial Navigation; Synapses; Triterpenes | 2015 |
Characterization of a Synthetic Steroid 24-keto-cholest-5-en-3β, 19-diol as a Neuroprotectant.
Topics: Animals; Animals, Newborn; Calcium; Cell Hypoxia; Cells, Cultured; Cerebellum; Cholestanols; Disease Models, Animal; Excitatory Amino Acid Agonists; Glutamic Acid; Infarction, Middle Cerebral Artery; L-Lactate Dehydrogenase; N-Methylaspartate; Neurons; Neuroprotective Agents; Oxygen; Rats; Rats, Sprague-Dawley | 2015 |
Exploring the role of MKK7 in excitotoxicity and cerebral ischemia: a novel pharmacological strategy against brain injury.
Topics: Amino Acid Sequence; Animals; Animals, Newborn; Antigens, Differentiation; Cell Hypoxia; Cerebral Cortex; Electrocoagulation; Gene Expression Regulation; Glucose; Infarction, Middle Cerebral Artery; JNK Mitogen-Activated Protein Kinases; Male; MAP Kinase Kinase 7; Molecular Docking Simulation; Molecular Sequence Data; N-Methylaspartate; Neurons; Neuroprotective Agents; Peptides; Primary Cell Culture; Protein Engineering; Rats; Rats, Sprague-Dawley; Signal Transduction; Thromboembolism; Tissue Culture Techniques | 2015 |
Naturally occurring marine steroid 24-methylenecholestane-3β,5α,6β,19-tetraol functions as a novel neuroprotectant.
Topics: Animals; Aquatic Organisms; Brain Ischemia; Cerebral Cortex; Cholestanols; Glutamic Acid; Infarction, Middle Cerebral Artery; Magnetic Resonance Spectroscopy; Male; Mice; N-Methylaspartate; Neurons; Neuroprotective Agents; Rats, Sprague-Dawley | 2016 |
Two different molecular mechanisms underlying progesterone neuroprotection against ischemic brain damage.
Topics: Animals; Behavior, Animal; Calcium; Cell Death; Disease Models, Animal; Hippocampus; Hormone Antagonists; Infarction, Middle Cerebral Artery; Male; Maze Learning; Memory; Mifepristone; Mitogen-Activated Protein Kinase 3; N-Methylaspartate; Neurofilament Proteins; Neuroprotective Agents; Progesterone; Protein Transport; Rats; Rats, Sprague-Dawley; Signal Transduction; Space Perception; Time Factors | 2008 |
Neuroprotection by nitrous oxide: facts and evidence.
Topics: Animals; Body Temperature; Brain; Brain Ischemia; Dopamine; Dose-Response Relationship, Drug; Glucose; In Vitro Techniques; Infarction, Middle Cerebral Artery; L-Lactate Dehydrogenase; Male; Motor Activity; N-Methylaspartate; Neuroprotective Agents; Nitrous Oxide; Oxygen; Rats; Rats, Sprague-Dawley | 2008 |
Essential role for zinc-triggered p75NTR activation in preconditioning neuroprotection.
Topics: Animals; Apoptosis; Calcium; Cell Culture Techniques; Cerebral Cortex; Cerebral Infarction; Chelating Agents; Disease Models, Animal; Edetic Acid; Embryo, Mammalian; Enzyme Activation; Excitatory Amino Acid Agonists; Infarction, Middle Cerebral Artery; Ischemic Preconditioning; Laser-Doppler Flowmetry; Male; Mice; Mice, Transgenic; N-Methylaspartate; Neurons; Poly(ADP-ribose) Polymerases; Rats; Rats, Sprague-Dawley; Receptor, Nerve Growth Factor; Time Factors; Zinc | 2008 |
Ischemic tolerance following low dose NMDA involves modulation of cellular stress proteins.
Topics: Animals; Brain; Calpain; Cytoprotection; Disease Models, Animal; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Hypoxia-Ischemia, Brain; Infarction, Middle Cerebral Artery; Ischemic Preconditioning; Male; Membrane Proteins; Molecular Chaperones; N-Methylaspartate; Neuroprotective Agents; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Stress, Physiological | 2009 |
Rescue of neurons from ischemic injury by peroxisome proliferator-activated receptor-gamma requires a novel essential cofactor LMO4.
Topics: Adaptor Proteins, Signal Transducing; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cell Death; Cell Hypoxia; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; Electrophoretic Mobility Shift Assay; Embryo, Mammalian; Gene Expression Regulation; Glucose; Homeodomain Proteins; Hypoglycemic Agents; Immunoprecipitation; Infarction, Middle Cerebral Artery; Kainic Acid; LIM Domain Proteins; Mice; Mice, Knockout; N-Methylaspartate; Neurons; Oxygen; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; PPAR gamma; Rosiglitazone; Signal Transduction; Superoxide Dismutase; Thiazolidinediones; Trans-Activators; Transcription Factors | 2008 |
Differential neuroprotection and risk for bleeding from activated protein C with varying degrees of anticoagulant activity.
Topics: Animals; Apoptosis; Cells, Cultured; Cerebral Hemorrhage; Endothelial Cells; Excitatory Amino Acid Agonists; Female; Fibrinolytic Agents; Humans; Infarction, Middle Cerebral Artery; Mice; Mice, Inbred C57BL; Mutation; N-Acetylneuraminic Acid; N-Methylaspartate; Neurons; Neuroprotective Agents; Partial Thromboplastin Time; Polysaccharides; Pregnancy; Protein C; Recombinant Proteins; Risk | 2009 |
Selective blockade of PGE2 EP1 receptor protects brain against experimental ischemia and excitotoxicity, and hippocampal slice cultures against oxygen-glucose deprivation.
Topics: Animals; Cinnamates; Dinoprostone; Glucose; Hippocampus; Hypoxia-Ischemia, Brain; Hypoxia, Brain; Infarction, Middle Cerebral Artery; Injections, Intraventricular; Male; Mice; Mice, Inbred C57BL; N-Methylaspartate; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP1 Subtype; Tissue Culture Techniques | 2008 |
Effects of exogenous excitatory amino acid neurotransmitters on blood-brain barrier disruption in focal cerebral ischemia.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Aminoisobutyric Acids; Animals; Blood-Brain Barrier; Brain Ischemia; Cerebral Cortex; Infarction, Middle Cerebral Artery; Male; N-Methylaspartate; Rats; Rats, Wistar; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate | 2009 |
Neuroprotective activities of activated protein C mutant with reduced anticoagulant activity.
Topics: Analysis of Variance; Animals; Antibodies; Anticoagulants; Apoptosis; Brain; Caspase 3; Caspase 9; Cells, Cultured; Embryo, Mammalian; Endothelial Cells; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Female; Glucose; Hemoglobins; Humans; Hypoxia; In Situ Nick-End Labeling; Infarction, Middle Cerebral Artery; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mutation; N-Methylaspartate; Neurons; Neuroprotective Agents; Pregnancy; Protein C; Receptors, Proteinase-Activated; Time Factors; Tumor Suppressor Protein p53 | 2009 |
GIF-0173 protects against cerebral infarction through DP1 receptor activation.
Topics: Animals; Brain Infarction; Calcium; Cell Death; Cells, Cultured; Cerebral Cortex; Cerebrovascular Circulation; Dantrolene; Disease Models, Animal; Dose-Response Relationship, Drug; Glutamic Acid; Hydantoins; Infarction, Middle Cerebral Artery; Intracellular Fluid; Lactones; Laser-Doppler Flowmetry; Male; N-Methylaspartate; Neurons; Neuroprotective Agents; Platelet Aggregation Inhibitors; Prostaglandin D2; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Immunologic; Receptors, Prostaglandin; Sesquiterpenes; Severity of Illness Index; Tetrazolium Salts | 2009 |
Combination treatment with ethyl pyruvate and aspirin enhances neuroprotection in the postischemic brain.
Topics: Animals; Aspirin; Astringents; Astrocytes; Brain Infarction; Cells, Cultured; Cerebral Cortex; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Embryo, Mammalian; Excitatory Amino Acid Agonists; Gene Expression Regulation; Glucose; Hypoxia; Infarction, Middle Cerebral Artery; Male; N-Methylaspartate; Neurons; Neuroprotective Agents; NF-kappa B; Polysaccharides; Pyruvates; Rats; Rats, Sprague-Dawley; Rotarod Performance Test; Severity of Illness Index; Time Factors; Zinc Sulfate | 2010 |
Carnosine protects against permanent cerebral ischemia in histidine decarboxylase knockout mice by reducing glutamate excitotoxicity.
Topics: Amino Acid Transport System X-AG; Animals; Apoptosis; Astrocytes; Carnosine; Glutamic Acid; Histidine Decarboxylase; Infarction, Middle Cerebral Artery; Male; Membrane Potential, Mitochondrial; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondria; N-Methylaspartate; Neuroprotective Agents; PC12 Cells; Rats; Reactive Oxygen Species; Rotenone | 2010 |
Endonuclease G does not play an obligatory role in poly(ADP-ribose) polymerase-dependent cell death after transient focal cerebral ischemia.
Topics: Adenosine Diphosphate Ribose; Animals; Apoptosis Inducing Factor; Caspases; Cell Death; D-Aspartic Acid; DNA Fragmentation; Endodeoxyribonucleases; Enzyme Inhibitors; Female; Infarction, Middle Cerebral Artery; Ischemic Attack, Transient; Mice; Mice, Knockout; N-Methylaspartate; Neurons; Poly Adenosine Diphosphate Ribose; Poly(ADP-ribose) Polymerases; Reperfusion; Stroke | 2010 |
The flavanol (-)-epicatechin prevents stroke damage through the Nrf2/HO1 pathway.
Topics: Animals; Catechin; Cells, Cultured; Cytoprotection; Heme Oxygenase-1; Infarction, Middle Cerebral Artery; Membrane Proteins; Mice; Mice, Knockout; N-Methylaspartate; NF-E2-Related Factor 2; Oxidative Stress; Protein Transport; Signal Transduction | 2010 |
KCa2 channels activation prevents [Ca2+]i deregulation and reduces neuronal death following glutamate toxicity and cerebral ischemia.
Topics: Animals; Brain Ischemia; Calcium Signaling; Cell Culture Techniques; Cell Death; Cells, Cultured; Excitatory Amino Acid Agonists; Glutamic Acid; Indoles; Infarction, Middle Cerebral Artery; Male; Mice; Mice, Inbred C57BL; N-Methylaspartate; Neurons; Neuroprotective Agents; Oximes; Small-Conductance Calcium-Activated Potassium Channels; Transcription, Genetic | 2011 |
Cerebroside-A provides potent neuroprotection after cerebral ischaemia through reducing glutamate release and Ca²⁺ influx of NMDA receptors.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Analysis of Variance; Animals; Brain Ischemia; Calcium; Cerebral Infarction; Cerebrosides; Charybdotoxin; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glucose; Glutamic Acid; Hippocampus; Hypoxia; In Vitro Techniques; Infarction, Middle Cerebral Artery; Long-Term Potentiation; Male; Mice; Mice, Inbred C57BL; N-Methylaspartate; Neuroprotective Agents; Neurotoxins; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Tetrazolium Salts; Valine | 2012 |
Excitotoxicity-induced endocytosis mediates neuroprotection by TAT-peptide-linked JNK inhibitor.
Topics: Analysis of Variance; Animals; Animals, Newborn; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; Endocytosis; Excitatory Amino Acid Agonists; Infarction, Middle Cerebral Artery; JNK Mitogen-Activated Protein Kinases; L-Lactate Dehydrogenase; N-Methylaspartate; Neurons; Neuroprotective Agents; Peptides; Phosphopyruvate Hydratase; Rats; Rats, Sprague-Dawley; Transfection | 2011 |
P2X7 receptor blockade prevents ATP excitotoxicity in neurons and reduces brain damage after ischemia.
Topics: Adenosine Triphosphate; Analysis of Variance; Animals; Brain Injuries; Calcium; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; Dose-Response Relationship, Drug; Embryo, Mammalian; Excitatory Amino Acid Agonists; Fluoresceins; Glucose; Hypoxia; In Vitro Techniques; Infarction, Middle Cerebral Artery; Membrane Potentials; N-Methylaspartate; Neurologic Examination; Neurons; Organic Chemicals; Patch-Clamp Techniques; Phosphopyruvate Hydratase; Purinergic P2X Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2X7; Rosaniline Dyes; Tetrazolium Salts | 2012 |
Ex vivo and in vivo neuroprotection induced by argon when given after an excitotoxic or ischemic insult.
Topics: Animals; Argon; Brain; Brain Injuries; Brain Ischemia; Disease Models, Animal; Dose-Response Relationship, Drug; Glucose; Infarction, Middle Cerebral Artery; Male; Models, Statistical; N-Methylaspartate; Neurons; Neuroprotective Agents; Oxygen; Rats; Rats, Sprague-Dawley; Synapses | 2012 |
L-theanine administration results in neuroprotection and prevents glutamate receptor agonist-mediated injury in the rat model of cerebral ischemia-reperfusion.
Topics: Animals; Brain; Camellia sinensis; Excitatory Amino Acid Agonists; Glutamates; Infarction, Middle Cerebral Artery; Male; N-Methylaspartate; Neuroprotective Agents; Rats; Rats, Wistar; Receptors, Glutamate; Reperfusion Injury; Tea | 2013 |
Increased severity of stroke in CB1 cannabinoid receptor knock-out mice.
Topics: Animals; Blood Flow Velocity; Blood Pressure; Brain; Cerebrovascular Circulation; Disease Models, Animal; Genotype; Heterozygote; Homozygote; Infarction, Middle Cerebral Artery; Male; Mice; Mice, Knockout; N-Methylaspartate; Neurons; Phenotype; Receptors, Cannabinoid; Receptors, Drug; Reperfusion; Stroke; Survival Rate | 2002 |
Selective blockade of endothelin-B receptors exacerbates ischemic brain damage in the rat.
Topics: Animals; Antihypertensive Agents; Blood Flow Velocity; Brain Ischemia; Cerebrovascular Circulation; Disease Models, Animal; Endothelin Receptor Antagonists; Excitatory Amino Acid Agonists; Gene Expression; Infarction, Middle Cerebral Artery; Injections, Intraventricular; Male; N-Methylaspartate; Oligopeptides; Piperidines; Rats; Rats, Sprague-Dawley; Receptor, Endothelin B; Receptors, Endothelin; RNA, Messenger | 2002 |
A peptide inhibitor of c-Jun N-terminal kinase protects against excitotoxicity and cerebral ischemia.
Topics: Adaptor Proteins, Signal Transducing; Animals; Behavior, Animal; Brain Ischemia; Carrier Proteins; Cells, Cultured; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Gene Products, tat; Genes, fos; In Vitro Techniques; Infarction, Middle Cerebral Artery; JNK Mitogen-Activated Protein Kinases; Male; Mice; Mice, Inbred ICR; Mitogen-Activated Protein Kinases; N-Methylaspartate; Neurons; Neuroprotective Agents; Peptides; Rats; Recombinant Proteins | 2003 |
Direct inhibition of the mitochondrial permeability transition pore: a possible mechanism responsible for anti-apoptotic effects of melatonin.
Topics: Animals; Apoptosis; Calcium Signaling; Cell Hypoxia; Corpus Striatum; Infarction, Middle Cerebral Artery; Inhibitory Concentration 50; Ion Channels; Ischemic Attack, Transient; Male; Melatonin; Mice; Mitochondria, Liver; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Models, Animal; N-Methylaspartate; Neuroprotective Agents; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Reperfusion Injury | 2004 |
Infarct reduction in rats following intraventricular administration of either tissue plasminogen activator (tPA) or its non-protease mutant S478A-tPA.
Topics: Animals; Brain; Brain Infarction; Brain Ischemia; Cells, Cultured; Coculture Techniques; Disease Models, Animal; Endopeptidases; Fetus; Infarction, Middle Cerebral Artery; Injections, Intraventricular; Male; Mice; Movement Disorders; Mutation; N-Methylaspartate; Protein Conformation; Rats; Rats, Sprague-Dawley; Tissue Plasminogen Activator; Treatment Outcome; Zinc | 2004 |
Neuroprotective actions of endogenous interleukin-1 receptor antagonist (IL-1ra) are mediated by glia.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Astrocytes; Brain Ischemia; Cell Death; Cells, Cultured; Coculture Techniques; Culture Media, Conditioned; Excitatory Amino Acid Agonists; Infarction, Middle Cerebral Artery; Interleukin 1 Receptor Antagonist Protein; Male; Mice; Mice, Knockout; Microglia; N-Methylaspartate; Neurons; Neuroprotective Agents; Perfusion; Sialoglycoproteins | 2006 |
HMGB1, a novel cytokine-like mediator linking acute neuronal death and delayed neuroinflammation in the postischemic brain.
Topics: Animals; Blotting, Northern; Blotting, Western; Brain; Cell Death; Cells, Cultured; Culture Media, Conditioned; Embryo, Mammalian; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Gene Expression; High Mobility Group Proteins; HMGB1 Protein; Infarction, Middle Cerebral Artery; Inflammation; Male; Mice; Microglia; N-Methylaspartate; Neurons; Rats; Rats, Sprague-Dawley; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Staurosporine; Time Factors; Transfection | 2006 |
Pretreatment with PTD-calbindin D 28k alleviates rat brain injury induced by ischemia and reperfusion.
Topics: Animals; Apoptosis; Blotting, Western; Brain; Brain Ischemia; Calbindins; Calcium; Cell Membrane; Chlorocebus aethiops; COS Cells; Cytosol; Escherichia coli; Excitatory Amino Acid Agonists; Glucose; Hippocampus; Hypoxia, Brain; Immunohistochemistry; In Situ Nick-End Labeling; In Vitro Techniques; Infarction, Middle Cerebral Artery; N-Methylaspartate; Neuroprotective Agents; Rats; Recombinant Proteins; Reperfusion Injury; S100 Calcium Binding Protein G; Signal Transduction | 2007 |
Marked prevention of ischemic brain injury by Neu2000, an NMDA antagonist and antioxidant derived from aspirin and sulfasalazine.
Topics: Animals; Antioxidants; Aspirin; Benzoates; Brain Ischemia; Cells, Cultured; Excitatory Amino Acid Antagonists; Fluorobenzenes; Infarction, Middle Cerebral Artery; meta-Aminobenzoates; Mice; N-Methylaspartate; Oxidative Stress; Receptors, N-Methyl-D-Aspartate; Salicylates; Sulfasalazine | 2007 |
Prolonged activation of ASIC1a and the time window for neuroprotection in cerebral ischaemia.
Topics: Acid Sensing Ion Channels; Acidosis; Animals; Brain; Brain Ischemia; Cerebral Cortex; Cerebral Ventricles; Cerebrovascular Circulation; Disease Models, Animal; Dose-Response Relationship, Drug; Hydrogen-Ion Concentration; Infarction, Middle Cerebral Artery; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; N-Methylaspartate; Nerve Tissue Proteins; Neuroprotective Agents; Sodium Bicarbonate; Sodium Channels; Spider Venoms; Time Factors | 2007 |
Stimulation of prostaglandin E2-EP3 receptors exacerbates stroke and excitotoxic injury.
Topics: Animals; Body Temperature; Brain Infarction; Brain Injuries; Cerebrovascular Circulation; Dinoprostone; Dose-Response Relationship, Drug; Drug Synergism; Infarction, Middle Cerebral Artery; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP3 Subtype | 2007 |
Neuroprotective effect of Smilacis chinae rhizome on NMDA-induced neurotoxicity in vitro and focal cerebral ischemia in vivo.
Topics: Animals; Calcium; Cell Death; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Infarction, Middle Cerebral Artery; Male; N-Methylaspartate; Neurons; Neuroprotective Agents; Plant Extracts; Plant Preparations; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Reperfusion Injury; Resveratrol; Rhizome; Smilax; Stilbenes; Time Factors | 2008 |
MRZ 2/579, a novel uncompetitive N-methyl-D-aspartate antagonist, reduces infarct volume and brain swelling and improves neurological deficit after focal cerebral ischemia in rats.
Topics: Animals; Brain Edema; Brain Ischemia; Cerebral Cortex; Cyclopentanes; Excitatory Amino Acid Agonists; Image Processing, Computer-Assisted; Infarction, Middle Cerebral Artery; Male; N-Methylaspartate; Neostriatum; Neurologic Examination; Neuroprotective Agents; Rats; Rats, Sprague-Dawley | 2000 |
Ischemia-induced interleukin-6 as a potential endogenous neuroprotective cytokine against NMDA receptor-mediated excitotoxicity in the brain.
Topics: Animals; Apoptosis; Astrocytes; Brain Chemistry; Cells, Cultured; Cerebral Cortex; Excitatory Amino Acid Agonists; Gene Expression; Infarction, Middle Cerebral Artery; Interleukin-6; Ionomycin; Ionophores; Ischemic Attack, Transient; Male; N-Methylaspartate; Neurons; Neuroprotective Agents; Neurotoxins; Polymerase Chain Reaction; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Interleukin-6; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Transcription, Genetic | 2000 |
Interleukin-10 modulates neuronal threshold of vulnerability to ischaemic damage.
Topics: Animals; Brain; Brain Ischemia; Cell Death; Cells, Cultured; Excitatory Amino Acid Agonists; Glucose; Infarction, Middle Cerebral Artery; Interleukin-10; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Necrosis; Neurons; Neurotoxins; Oxygen; Recombinant Proteins; Tumor Necrosis Factor-alpha | 2000 |
Presenilin-1 regulates the neuronal threshold to excitotoxicity both physiologically and pathologically.
Topics: Alzheimer Disease; Animals; Brain; Cells, Cultured; Disease Models, Animal; Excitatory Amino Acid Agonists; Gene Expression; Humans; Infarction, Middle Cerebral Artery; Kainic Acid; Membrane Proteins; Mice; Mice, Knockout; Mice, Transgenic; N-Methylaspartate; Nerve Degeneration; Neurons; Presenilin-1 | 2000 |
Increased susceptibility to ischemic brain injury in cyclooxygenase-1-deficient mice.
Topics: Animals; Brain; Brain Ischemia; Cerebrovascular Circulation; Cyclooxygenase 1; Disease Susceptibility; Excitatory Amino Acid Agonists; Female; Infarction, Middle Cerebral Artery; Isoenzymes; Kainic Acid; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Neurotoxins; Parietal Lobe; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Stroke | 2001 |
Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice.
Topics: Age of Onset; Amyotrophic Lateral Sclerosis; Animals; Caspases; Cell Death; Cells, Cultured; Cerebral Cortex; Cytochrome c Group; Disease Progression; Enzyme Activation; Humans; Infarction, Middle Cerebral Artery; Ischemia; Mice; Mice, Inbred C57BL; Minocycline; Mitochondria; Mitochondrial Swelling; N-Methylaspartate; Permeability; Rats; Survival Rate; Tumor Cells, Cultured | 2002 |
NS 1231, a novel compound with neurotrophic-like effects in vitro and in vivo.
Topics: Animals; Cell Survival; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Enzyme Activation; Gerbillinae; Hippocampus; In Vitro Techniques; Indoles; Infarction, Middle Cerebral Artery; Ischemic Attack, Transient; Mice; Mitogen-Activated Protein Kinases; N-Methylaspartate; Nerve Growth Factor; Nerve Growth Factors; Neurites; Neurons; Neuroprotective Agents; Oximes; PC12 Cells; Phosphorylation; Rats; Receptor, trkA; Signal Transduction | 2002 |