n-methylaspartate has been researched along with Down Syndrome in 9 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 4 (44.44) | 29.6817 |
| 2010's | 4 (44.44) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Altafaj, X; Andreu, N; Ceña, V; Dierssen, M; Fernández, M; Fillat, C; González-García, C; Laffaire, J; Martí, E; Ortiz-Abalia, J; Potier, MC | 1 |
| Alves-Sampaio, A; Montesinos, ML; Troca-Marín, JA | 1 |
| Costa, AC; Scott-McKean, JJ | 1 |
| Aarsland, D; Ballard, C; Bullock, R; Corbett, A; Francis, PT; Hanney, M; Johnson, T; Jones, EL; Lawrence, D; Prasher, V; Tyrer, S; Williams, N; Yu, LM | 1 |
| Garner, CC; Wetmore, DZ | 1 |
| Behar, TN; Colton, CA | 1 |
| Arqué, G; de Lagrán, MM; Dierssen, M; Fillat, C; Ortiz-Abalia, J | 1 |
| Coan, EJ; Galdzicki, Z; Rapoport, SI; Siarey, RJ | 1 |
| Caruso, A; Castellino, FJ; Galdzicki, Z; Klein, RC; Rapoport, SI; Siarey, RJ | 1 |
2 review(s) available for n-methylaspartate and Down Syndrome
| Article | Year |
|---|---|
Synaptic pathology of Down syndrome.
Topics: Animals; Chromosomes, Human, Pair 21; Disease Models, Animal; Down Syndrome; Gene Expression Regulation; Hippocampus; Humans; Long-Term Potentiation; Mice; Mice, Transgenic; Molecular Targeted Therapy; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission; Trisomy | 2012 |
Pitfalls and hopes in Down syndrome therapeutic approaches: in the search for evidence-based treatments.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain; Disease Models, Animal; Down Syndrome; Evidence-Based Medicine; Humans; Infant; Mice; N-Methylaspartate; Phenotype | 2006 |
1 trial(s) available for n-methylaspartate and Down Syndrome
| Article | Year |
|---|---|
Memantine for dementia in adults older than 40 years with Down's syndrome (MEADOWS): a randomised, double-blind, placebo-controlled trial.
Topics: Adult; Alzheimer Disease; Cognition; Dementia; Double-Blind Method; Down Syndrome; Female; Humans; Male; Memantine; Middle Aged; N-Methylaspartate | 2012 |
6 other study(ies) available for n-methylaspartate and Down Syndrome
| Article | Year |
|---|---|
Increased NR2A expression and prolonged decay of NMDA-induced calcium transient in cerebellum of TgDyrk1A mice, a mouse model of Down syndrome.
Topics: Animals; Blotting, Western; Calcium; Cells, Cultured; Cerebellum; Disease Models, Animal; Down Syndrome; Dyrk Kinases; Gene Expression Profiling; Immunohistochemistry; In Vitro Techniques; Male; Mice; Mice, Transgenic; N-Methylaspartate; Neurons; Oligonucleotide Array Sequence Analysis; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Receptors, N-Methyl-D-Aspartate; Synaptosomes; Up-Regulation | 2008 |
NMDA-mediated regulation of DSCAM dendritic local translation is lost in a mouse model of Down's syndrome.
Topics: Animals; Animals, Newborn; Cell Adhesion Molecules; Cells, Cultured; Dendrites; Disease Models, Animal; Down Syndrome; Female; Hippocampus; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; N-Methylaspartate; Neuronal Plasticity; Protein Biosynthesis; Xenopus laevis | 2010 |
Exaggerated NMDA mediated LTD in a mouse model of Down syndrome and pharmacological rescuing by memantine.
Topics: Analysis of Variance; Animals; Disease Models, Animal; Down Syndrome; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Hippocampus; In Vitro Techniques; Long-Term Synaptic Depression; Memantine; Methoxyhydroxyphenylglycol; Mice; Mice, Mutant Strains; N-Methylaspartate; Time Factors; Trisomy | 2011 |
Redox regulation of neuronal migration in a Down Syndrome model.
Topics: Acetylcysteine; Animals; Chemotaxis; Disease Models, Animal; Dithiothreitol; Down Syndrome; Fetus; Glutamic Acid; Mice; N-Methylaspartate; Neurons; Oxidation-Reduction; Oxidative Stress; Receptors, N-Methyl-D-Aspartate; Trisomy | 2003 |
Responses to NMDA in cultured hippocampal neurons from trisomy 16 embryonic mice.
Topics: Animals; Cells, Cultured; Disease Models, Animal; Down Syndrome; Evoked Potentials; Excitatory Amino Acid Agonists; Hippocampus; Mice; N-Methylaspartate; Neurons; Patch-Clamp Techniques | 1997 |
Increased expression of NR2A subunit does not alter NMDA-evoked responses in cultured fetal trisomy 16 mouse hippocampal neurons.
Topics: Animals; Chromosome Mapping; Diploidy; Disease Models, Animal; Down Syndrome; Evoked Potentials; Female; Heterozygote; Hippocampus; Humans; Male; Membrane Potentials; Mice; Mice, Mutant Strains; N-Methylaspartate; Neurons; Receptors, N-Methyl-D-Aspartate; Spermine; Trisomy; Zinc | 2001 |