n-methylaspartate has been researched along with Disease Models, Animal in 519 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (0.77) | 18.7374 |
| 1990's | 65 (12.52) | 18.2507 |
| 2000's | 179 (34.49) | 29.6817 |
| 2010's | 232 (44.70) | 24.3611 |
| 2020's | 39 (7.51) | 2.80 |
| Authors | Studies |
|---|---|
| Braisted, J; Dranchak, P; Earnest, TW; Gu, X; Hoon, MA; Inglese, J; Oliphant, E; Solinski, HJ | 1 |
| Abrams, RPM; Bachani, M; Balasubramanian, A; Brimacombe, K; Dorjsuren, D; Eastman, RT; Hall, MD; Jadhav, A; Lee, MH; Li, W; Malik, N; Nath, A; Padmanabhan, R; Simeonov, A; Steiner, JP; Teramoto, T; Yasgar, A; Zakharov, AV | 1 |
| Cebulla, CM; Hamadmad, S; Heisler-Taylor, T; Racine, J; Shah, MH; Urbanski, EG; Wan, R; Wilson, H | 1 |
| Cheng, L; Hou, C; Xiao, L; Yan, N; Zhao, L; Zheng, S | 1 |
| Furiya, M; Harashima, M; Hashizume, T; Hayashi, H; Mise, K; Mori, M; Mukaigaito, C; Takagi, N; Takemura, E; Yamada, M; Yuan, B | 1 |
| Fujita, K; Ge, S; Himori, N; Maekawa, S; Nakazawa, T; Nishiguchi, KM; Ohno-Oishi, M; Omodaka, K; Ozawa, M; Sato, K; Sato, T; Shiga, Y; Yabana, T; Yasuda, M | 1 |
| Janicot, R; Shao, LR; Stafstrom, CE | 1 |
| Cheng, J; Lu, L; Lv, Q; Ma, Z; Ren, Q; Wang, K; Wang, X; Zhang, S; Zhao, X | 1 |
| Hložek, T; Kubová, H; Mareš, P; Páleníček, T; Uttl, L | 1 |
| Li, L; Liu, J; Tang, J; Wang, H; Zhou, L | 1 |
| Brahma, MM; Goshima, Y; Harada, T; Namekata, K; Ohshima, T; Takahashi, K | 1 |
| Cao, Q; Duan, WM; Rein, B; Tan, T; Wang, W; Yan, Z; Zhang, F | 1 |
| Acebes, Á; Acevedo-Arozena, A; Brito-Armas, JM; Cuesto, G; Estévez-Silva, HM; Marcellino, DJ; Romero, N | 1 |
| Calamandrei, G; Cubadda, F; Di Benedetto, R; Ferraris, F; Midali, M; Minghetti, L; Mirabello, A; Raggi, A; Ricceri, L; Serafini, MM; Tartaglione, AM; Viviani, B | 1 |
| Bhatia, A; Joshi, R; Kaur, G; Kumar, R; Medhi, B; Mishra, A; Prajapat, M; Sarma, P; Sharma, A; Singla, R | 1 |
| Chen, F; Gao, M; Li, L; Li, Q; Peng, M; Wang, Y; Wu, Y; Yan, Y; Yang, J; Yang, L; Yang, X | 1 |
| Baeta-Corral, R; De la Fuente, M; Giménez-Llort, L | 1 |
| Behar-Cohen, F; Bigot, K; Bordet, T; Fan, Y; Inman, DM; Jaworski, T; Kodati, B; Nsiah, NY; Pappenhagen, N; Picard, E; Youale, J | 1 |
| Kim, EJ; Kim, K; Kim, MJ; Lee, M; Yeom, J; Yum, MS | 1 |
| Chachua, T; Chern, CR; Velíšek, L; Velíšková, J | 1 |
| Kim, EJ; Kim, MJ; Ko, TS; Lee, M; Woo, DC; Yum, MS | 1 |
| Hayashi, H; Inoue, D; Iwatani, Y; Ohata, M; Sato, S; Suzuki, K; Takagi, N; Yamada, M; Yuan, B | 1 |
| Guo, X; Harada, C; Harada, T; Honda, S; Kimura, A; Matsuda, A; Murakami, A; Namekata, K | 1 |
| Chan, TTH; Chan, WY; Feng, B; Gao, L; Hobbs, R; Hou, HW; Jiang, X; Lee, TL; Lee, WT; Leung, KS; Li, I; Li, K; Liao, J; Liu, YH; Luk, CS; Mak, HK; Ng, JKW; Ng, TK; Qi, H; Qian, Y; Rudd, JA; Suen, HC | 1 |
| Deng, Q; Jiang, M; Li, Y; Ma, X; Shen, Y; Xing, Y; Zhao, Q | 1 |
| Meng, Y; Ren, WH; Shi, XY; Wan, L; Wang, J; Yang, G; Zou, LP | 1 |
| Liu, S; Luo, X; Nawy, S; Shen, Y | 1 |
| Fan, H; Huang, J; Lai, X; Liu, A; Qiao, L; Shen, M; Wu, J; Yan, J | 1 |
| Baya Mdzomba, J; Behar-Cohen, F; Dirani, A; Joly, S; Lassiaz, P; Pernet, V; Rodriguez, L | 1 |
| Gotoh, N; Hasegawa, T; Iida, K; Ikeda, HO; Iwai, S; Kakizuka, A; Nakano, N; Tsujikawa, A | 1 |
| Bennett, DJ; Birch, D; Heckman, CJ; Jiang, MC; Thaweerattanasinp, T; Tresch, MC; Tysseling, VM | 1 |
| Foutz, TJ; Friedman, JL; Galindo, R; Johnson, KJ; Rensing, N; Wong, M | 1 |
| Gammon, ST; Jacobsen, MC; Le Roux, LG; Pagel, MD; Piwnica-Worms, DR; Qiu, X; Schellingerhout, D | 1 |
| Benke, D; Pietrobon, D; Romanos, J; Santello, M; Zeilhofer, HU | 1 |
| Fujishita, S; Igarashi, T; Kameya, S; Kobayashi, M; Nakamoto, K; Okada, T; Shiozawa, AL; Takahashi, H | 1 |
| Jones, NC; Lee, J; Nithianantharajah, J; van den Buuse, M | 1 |
| Arizono, I; Fujita, N; Kitaoka, Y; Sase, K; Takagi, H; Tsukahara, C | 1 |
| Alejandro, EU; Gustafson, E; Lockridge, A; Miller, RF; Wong, A | 1 |
| Li, Z; Shi, X; Sun, Y; Wan, L; Wang, J; Yang, G; Zhang, S | 1 |
| Cerne, R; Izenwasser, S; Newman, AH; Smith, JL; Tortella, FC; Witkin, JM | 1 |
| Fujita, M; Nakagawasai, O; Nemoto, W; Tan-No, K; Yamagata, R | 1 |
| Ayuso-Dolado, S; Díaz-Guerra, M; Esteban-Ortega, GM; Vidaurre, ÓG | 1 |
| He, Y; Peng, J; Peng, M; Rui, Y; Song, W; Wang, C; Wang, Y; Xia, X; Zhang, X; Zhou, X | 1 |
| Beazely, MA; Gondora, N; Mielke, JG; Pople, CB; Robinson, M; Solomon, E; Tandon, G | 1 |
| Canzar, S; Christian, KM; Dawson, TM; Dawson, VL; Eacker, S; Hsu, KS; Kim, NS; Li, W; Lin, YT; Ming, GL; Nguyen, HN; Ringeling, FR; Song, H; Temme, SJ; Worley, P; Xiao, B; Yoon, KJ; Zhou, Y | 1 |
| Dahlén, A; Guo, S; Melgoza, A; Wagle, M; Zarei, M | 1 |
| Beitz, AJ; Kaang, BK; Kim, YH; Ko, HG; Kwon, SG; Lee, JH; Oh, SB; Roh, DH; Yeo, JH; Yoon, SY | 1 |
| Chen, Z; Li, Z; Zhang, H; Zhong, Z; Zhou, Z | 1 |
| Chen, Y; Liang, J; Liu, X; Qu, C; Shi, S; Yang, B; Yang, H | 1 |
| Elefant, F; Gao, WJ; Gulchina, Y; Snyder, MA; Xu, SJ | 1 |
| Asahara, H; Fukaya, M; Hagiwara, M; Kobayashi, S; Komano-Inoue, S; Manabe, H; Manabe, T; Mizuguchi, M; Murakami, T; Ogonuki, N; Ogura, A; Okuda, K; Sakagami, H; Sato, T; Tanaka, T; Ueno, H; Watanabe, A; Yamaguchi, M | 1 |
| Coimbra, NC; da Silva Soares, R; Dos Anjos-Garcia, T; Falconi-Sobrinho, LL | 1 |
| Akbarian, R; Chamanara, M; Dehpour, AR; Ghasemi, M; Imran-Khan, M; Norouzi-Javidan, A; Ostadhadi, S | 1 |
| Daigaku, R; Fujita, K; Maekawa, S; Maruyama, K; Moritoh, S; Murayama, N; Nakazawa, T; Nishiguchi, KM; Omodaka, K; Sato, K; Shiga, Y; Tawarayama, H; Yabana, T | 1 |
| Attwell, D; Bazargani, N; Jolly, S; Li, H; Pringle, NP; Quiroga, AC; Richardson, WD | 1 |
| Cho, SJ; Lovinger, DM; N'Gouemo, P | 1 |
| Alobid, I; Berenguer, J; Bernabeu, M; Langdon, C; Laxe, S; Lehrer, E; Marin, C; Mariño-Sánchez, F; Mullol, J | 1 |
| Bertani, I; Chiesa, R; Foray, C; Iori, V; Mantovani, S; Maroso, M; Tonini, R; Trusel, M; Vezzani, A | 1 |
| Antonini, A; Biocca, S; Caioli, S; Canu, N; Saba, L; Vindigni, G; Zona, C | 1 |
| Amitai, N; Powell, SB; Young, JW | 1 |
| Arima, S; Asano, D; Ishii, K; Kondo, R; Mori, A; Nagamitsu, T; Nakahara, T; Nakano, A; Sakamoto, K; Ushikubo, H | 1 |
| Cui, H; Jin, Y; Li, Q; Li, R; Sun, X; Zhu, H | 1 |
| Melo-Thomas, L; Schwarting, R; Tonelli, LC; Wöhr, M | 1 |
| Estrada-Leyva, B; Lamas, M; Quintero, H; Reyes-Aguirre, LI | 1 |
| Hu, L; Liu, M; Pan, S; Pei, L; Shang, Y; Song, L; Wu, Y; Xian, W; Xiong, W; Yao, S | 1 |
| Chang, JW; Jung, HH; Koh, CS; Kong, C; Lee, J; Shin, J; Yoon, MS | 1 |
| Dou, M; Gong, A; Han, L; Liang, H; Ma, A; Wang, Q; Wu, Y | 1 |
| Bellone, C; Bimpisidis, Z; Creed, M; Dorst, MC; Dumas, S; Lüscher, C; Papathanou, M; Pettersson, H; Silberberg, G; Wallén-Mackenzie, Å | 1 |
| Cortés-Montero, E; Garzón, J; Onetti, Y; Rodríguez-Muñoz, M; Sánchez-Blázquez, P | 1 |
| Lei, HW; Wang, JY; Zhang, JH; Zhao, YH | 1 |
| Asaka, N; Kishimoto, I; Kita, T; Matsunaga, M; Nakagawa, T; Omori, K; Yamahara, K; Yamamoto, N | 1 |
| Chern, CJ; Chern, CR; Velíšek, L; Velíšková, J | 1 |
| Asano, D; Ishii, K; Mori, A; Morita, A; Nakahara, T; Sakamoto, K | 1 |
| Huang, XT; Li, XH; Li, Y; Luo, ZQ; Peng, XP | 1 |
| Chen, HC; Chiu, CH; Huang, YS; Kang, HH; Li, IH; Liu, CT; Ma, KH; Shih, JH; Shiue, CY; Wang, CH | 1 |
| Al-Baggou, BK; Salih, NA | 1 |
| Huang, XT; Liu, W; Sun, CC; Sun, M; Tang, SY; Zhang, CY; Zhou, Y | 1 |
| Haydon, PG; Hines, DJ | 1 |
| Biondi, O; Branchu, J; Chali, F; Chanoine, C; Charbonnier, F; Collin, T; Leroy, F; Lopes, P; Makoukji, J; Mamchaoui, K; Massaad, C; Pariset, C | 1 |
| Anwar, MA; Lloyd-Burton, SM; Roskams, AJ; Vincent, AJ; York, EM | 1 |
| Amini, M; Baudry, M; Beique, JC; Bergeron, R; Farazifard, R; Greer, PA; Hage, F; Lagace, DC; Ma, CL; Park, DS; Savitt, JM; Slack, RS; Vanderluit, J; Zhang, Y; Zhu, G; Zoltewicz, JS | 1 |
| Ahmadi, H; Nasehi, M; Rostami, P; Zarrindast, MR | 1 |
| Alberch, J; Brito, V; del Toro, D; Ginés, S; Giralt, A; Puigdellívol, M | 1 |
| Dong, Z; Girling, K; Lee, W; Lin, SZ; Shyu, WC; Taghibiglou, C; Wang, YT; Zhang, S | 1 |
| Chagneau, C; Dallerac, G; Davis, S; Farley, S; Hanauer, A; Laroche, S; Morice, E; Pannetier, S; Poirier, R; Vaillend, C | 1 |
| Harada, T; Kurosaka, D; Machida, S; Nishimura, T | 1 |
| Potapenko, ES; Stern, JE | 1 |
| Guo, X; Harada, C; Harada, T; Kawamura, K; Kimura, A; Namekata, K; Tanaka, K | 1 |
| Choi, Y; Gu, J; Hwang, S; Ju, C; Kim, C; Kim, M; Kim, WK; Kwon, J; Lee, K; Oh, YK; Song, S | 1 |
| Baldwin, R; Liu, H; Naylor, DE; Niquet, J; Wasterlain, CG | 1 |
| Chen, P; Chen, S; Deng, Y; Wei, J; Xiong, Z; Yan, Z | 1 |
| Hamada, S; Hamaguchi-Hamada, K; Hirashima, H; Imaeda, M; Kurumata-Shigeto, M; Okamoto, Y | 1 |
| Nagaoka, T; Nakabayashi, S; Tani, T; Yoshida, A; Yoshioka, T | 1 |
| Bannerman, D; Dix, SL; Garner, JP; Gaskill, BN; Gilmour, G; Pioli, EY; Tricklebank, MD | 1 |
| Fan, J; Leavitt, BR; Lu, G; Park, KH; Raymond, LA | 1 |
| An, Y; Belevych, N; Chen, Q; Herschman, H; Quan, N; Wang, Y; Zhang, H | 1 |
| Dudka, J; Oniszczuk, T; Poleszak, E; Serefko, A; Szopa, A; Wlaź, P; Wośko, S; Wróbel, A | 1 |
| Huang, YJ; Lane, HY; Lin, CH; Lin, CJ; Tsai, GE | 1 |
| Ahn, HR; Jang, H; Jung, SH; Kim, CY; Kim, KA; Lee, CY; Lee, HJ; Nho, CW; Pan, CH | 1 |
| Baek, CW; Choi, GJ; Jung, YH; Kang, H; Kim, JY; Kim, WJ; Shin, HY; Woo, YC; Yon, JH | 1 |
| Battaglia, GS; Colciaghi, F; Finardi, A; Locatelli, D; Nobili, P; Spigolon, G | 1 |
| Alberch, J; Ceña, V; Collon, KW; Domercq, M; Fernández-Díez, B; Franco, R; Giralt, A; Giralt, E; Gottlieb, M; Lopez, I; Martínez-Pinilla, E; Matute, C; Moreno, B; Parent, JM; Posadas, I; Sánchez-Gómez, MV; Teixido, M; Villoslada, P; Zhang, H | 1 |
| Seitz, R; Tamm, ER | 2 |
| Hayden, MR; Kolodziejczyk, K; Parsons, MP; Raymond, LA; Southwell, AL | 1 |
| Bortz, DM; Bruno, JP; Jørgensen, CV; Mikkelsen, JD | 1 |
| Espallergues, J; Lüscher, C; O'Connor, EC; Pascoli, V; Terrier, J; Valjent, E | 1 |
| Ammassari-Teule, M; Bagetta, V; Calabresi, P; Costa, C; Fejtova, A; Ghiglieri, V; Gundelfinger, ED; Morelli, E; Pendolino, V; Picconi, B; Pignataro, A | 1 |
| Abraham, R; Nirogi, R; Shinde, A | 1 |
| Cai, SP; Fan, N; Guo, L; Kaufman, PL; Liu, X; Wang, Y; Yang, Q; Yin, Y; Zhou, X | 1 |
| Asami, Y; Asano, D; Ishii, K; Kurauchi, Y; Mori, A; Nakahara, T; Sakamoto, K | 1 |
| Shang, AJ; Wang, J; Yang, G; Zhang, Y; Zou, LP | 1 |
| Ding, S; Hu, J; Huang, W; Lin, Y; Liu, L; Lu, Q; Wang, X; Yang, J; Ye, Y | 1 |
| Lu, XY; Wang, X; Zhang, D | 1 |
| Borsello, T; Calabresi, P; Costa, C; de Iure, A; Di Filippo, M; Ghiglieri, V; Sclip, A; Tantucci, M; Tozzi, A | 1 |
| Dehpour, AR; Heidary, MR; Javadi-Paydar, M; Jazaeri, F; Rahimi, N; Sadeghzadeh, M | 1 |
| Chopra, K; Dhir, A | 1 |
| Kuo, CC; Lai, WS; Liu, WC; Pan, MK; Pei, JC; Tai, CH | 1 |
| Ko, TS; Lee, M; Velíšek, L; Yum, MS | 1 |
| Fischer, AJ; Milani-Nejad, N; Zelinka, C | 1 |
| Braunger, BM; Fuchshofer, R; Gallenberger, M; Iwata, T; Koch, M; Kroeber, M; März, L; Tamm, ER | 1 |
| Asano, D; Ishii, K; Mori, A; Nakahara, T; Sakamoto, K | 1 |
| Chen, L; Chen, T; Hong, J; Jie, P; Li, L; Sha, S; Sokabe, M; Wang, C; Yin, J; Zhou, R | 1 |
| Fiedorowicz, M; Grieb, P; Rejdak, R; Schuettauf, F; Thaler, S; Wozniak, M | 1 |
| da Costa, FL; de Oliveira, AC; Gomez, MV; Gomez, RS; Lima, IV; Mendes-Goulart, VA; Pinto, MC; Resende, RR; Romano-Silva, MA; Rosa, DV | 1 |
| Aguiar, DC; Hott, SC; Moreira, FA; Resstel, LB; Viana, TG | 1 |
| Benn, A; Robinson, ES | 1 |
| Chopek, JW; Cowley, KC; MacNeil, BJ; Schmidt, BJ; Sutherland, S | 1 |
| Landeira-Fernandez, J | 1 |
| Ghasemzadeh, Z; Ghazvini, H; Rezayof, A; Zarrindast, MR | 1 |
| Fantin, M; Morari, M | 1 |
| Chen, Z; Lei, B; Lei, C; Yang, H; Zheng, C; Zheng, S | 1 |
| Cheng, EY; Fu, WY; Ip, FC; Ip, NY; Liang, Y; Lok, KC; Tong, EP; Ye, WC | 1 |
| Boriushkin, E; Jing, G; Li, J; Seigel, GM; Wang, JJ; Zhang, SX | 1 |
| Chen, XY; Huang, YJ; Leng, TD; Liu, AL; Ou, YQ; Qiu, PX; Su, XW; Tang, LP; Yan, GM; Yan, M; Yin, W; Zhang, JX; Zhou, SJ | 1 |
| Amin-Yavari, S; Ebrahimi-Ghiri, M; Nasehi, M; Torabi-Nami, M; Zarrindast, MR | 1 |
| Hanada, M; Ishii, K; Mori, A; Nakahara, T; Sakamoto, K | 1 |
| Choragiewicz, TJ; Gasior, M; Rejdak, R; Schuettauf, F; Thaler, S; Zarnowska, I; Zarnowski, T; Zrenner, E | 1 |
| Chara, JC; Cipriani, R; Matute, C; Rodríguez-Antigüedad, A | 1 |
| Fujimura, K; Ishii, K; Kurauchi, Y; Mizuta, A; Mori, A; Nakahara, T; Sakamoto, K | 1 |
| Gupta, N; Kouser, M; Liu, S; Ochoa, CF; Powell, CM; Reimers, JM; Speed, HE; Xuan, Z | 1 |
| Corrêa da Silva, JA; da Silva, LM; de Souza, MM; Holzmann, I; Steimbach, VM | 1 |
| Brar, J; Chester, SJ; Goodkin, HP; Hawk, KM; Joshi, S; Rajasekaran, K; Ross, BM; Tran, CA | 1 |
| Ambrósio, AF; Cordeiro, MF; Elvas, F; Galvao, J; Martins, T; Santiago, AR | 1 |
| Chao, OY; de Souza Silva, MA; Huston, JP; Petri, D; Schnitzler, A | 1 |
| Chen, P; Cheng, Q; Gong, S; Luo, L; Song, J; Xiao, H | 1 |
| Kiyoyuki, Y; Kobayashi, K; Nakatsuka, T; Nishio, N; Noguchi, K; Okubo, M; Taniguchi, W; Yamanaka, H | 1 |
| Asgar, J; Chung, MK; Ro, JY; Saloman, JL; Wang, S; Zhang, Y | 1 |
| Kim, DW; Ko, TS; Lee, M; Velíšek, L; Woo, DC; Yum, MS | 1 |
| Aoki, Y; Asano, D; Hayashi, I; Ishii, K; Mori, A; Nakahara, T; Sakamoto, K; Ushikubo, H | 1 |
| Hirose, S; Hu, LY; Ju, J; Shi, XY; Tomonoh, Y; Yang, XF; Zou, LP | 1 |
| Aguiar, DC; Almeida-Santos, AF; Gobira, PH; Guimaraes, FS; Moreira, FA | 1 |
| Becker, S; Brown, RA; Charteris, DG; Eastlake, K; Jayaram, H; Jones, MF; Khaw, PT; Limb, GA; McLellan, GJ | 1 |
| Cortés, P; Harraz, MM; Snyder, SH; Tyagi, R | 1 |
| Kato, F; Takahashi, Y; Tsuji, M; Watabe, AM | 1 |
| Kreitzer, AC; Lalive, AL; Parker, PR | 1 |
| Andreazza, AC; Elmi, N; Isaacs-Trepanier, C; Kim, HK; Rapoport, SI | 1 |
| Crystal, JD; Hohmann, AG; Kulkarni, PM; Lai, YY; Smith, AE; Thakur, GA; Xu, Z | 1 |
| Paruszewski, R; Świąder, K; Świąder, MJ; Turski, WA; Łuszczki, JJ | 1 |
| Fritschy, JM; Jirak, D; Kleteckova, L; Kubesova, A; Rambousek, L; Vales, K | 1 |
| Carvalho, RV; da Silva Ferreira, F; Fernandes, C; Heimfarth, L; Pessoa-Pureur, R; Pierozan, P | 1 |
| Ju, J; Shang, NX; Shi, XY; Wang, J; Zhang, JY; Zhao, JB; Zou, LP | 1 |
| Rune, GM; Santer, R; Schlegel, G; Scholz, R; Ullrich, K | 1 |
| Hu, D; Liang, J; Liu, T; Shi, S; Wang, D; Yang, B; Zhang, Y | 1 |
| Achuta, VS; Castrén, ML; Grym, H; Kärkkäinen, V; Koistinaho, J; Louhivuori, V; Putkonen, N; Roybon, L | 1 |
| Andrade, C; Batlle, M; Gimeno-Bayón, J; Mahy, N; Martínez-Moreno, M; Ortega, FJ; Rodríguez, MJ | 1 |
| Ma, LQ; Peng, YZ; Shen, FY; Wang, B; Wang, ZR; Wen, W; Zhang, TT; Zhao, X | 1 |
| Björkholm, C; Feltmann, K; Jardemark, K; Konradsson-Geuken, Å; Malmerfelt, A; Marcus, MM; Möller, A; Påhlsson, N; Schilström, B; Svensson, TH | 1 |
| Amédée, T; Borralleras, C; Campuzano, V; Mato, S; Matute, C; Mulle, C; Pérez-Jurado, LA | 1 |
| Heckman, CJ; Thaweerattanasinp, T; Tysseling, VM | 1 |
| Bang, S; Berta, T; Chen, G; Chen, W; Gao, YJ; Ji, RR; Lay, M; Park, CK; Xie, RG; Xu, ZZ; Zhao, LX | 1 |
| Bermúdez-Rattoni, F; Delint-Ramírez, I; Díaz-Cintra, S; Morin, JP | 1 |
| Cruz, SL; Gauthereau-Torres, MY; Rivera-García, MT | 1 |
| Cunningham, CJ; Liu, X; Patel, KP; Sharma, NM; Zheng, H | 1 |
| Anand, A; Banik, A; Jindal, N; Prabhakar, S; Vaiphie, K | 1 |
| Beitz, AJ; Choi, HS; Choi, SR; Han, HJ; Kang, SY; Kwon, SG; Lee, JH; Moon, JY; Roh, DH; Yoon, SY | 1 |
| Amin, ND; Binukumar, BK; Grant, P; Kesavapany, S; Kuntz, S; Mishra, SK; Pant, HC; Reddy, P; Seo, J; Shukla, V; Steiner, J; Tsai, LH | 1 |
| Burat, I; Dalkilic, N; Tuncer, S | 1 |
| Gong, Y; Guo, F; Jin, H; Liu, F; Liu, Y; Wang, S; Xu, L | 1 |
| Hirooka, K; Kobayashi, M; Nakano, Y; Nishiyama, A; Ono, A; Tsujikawa, A | 1 |
| Cheng, B; Huang, Y; Li, D; Liu, G; Shen, W; Su, J; Zhang, YX; Zhou, WX | 1 |
| Bereiter, DA; Okamoto, K; Rahman, M; Shiozaki, K; Thompson, R | 1 |
| Borges, K; Denhardt, DT; Dingledine, R; Gearing, M; Kotloski, R; Rittling, S; Sorensen, ES | 1 |
| Agey, P; Dong, CJ; Guo, Y; Hare, WA; Wheeler, L | 1 |
| Cai, W; Chen, L; Furuya, K; Li, Z; Sokabe, M; Zhu, Y | 1 |
| Coleman, BR; Doctor, BP; Gordon, RK; Nambiar, MP; Oguntayo, SA; Ratcliffe, RH; Shi, X | 1 |
| Gray, TS; Mickiewicz, AL; Napier, TC; Turner, MS | 1 |
| Bertoglio, LJ; Carobrez, AP; Moraes, CL | 1 |
| Altafaj, X; Andreu, N; Ceña, V; Dierssen, M; Fernández, M; Fillat, C; González-García, C; Laffaire, J; Martí, E; Ortiz-Abalia, J; Potier, MC | 1 |
| Cavaliere, A; Ciavardelli, D; di Ilio, C; Drago, D; Mascetra, N; Sensi, SL; Zatta, P | 1 |
| Huang, J; Ji, ES; Liu, Y; Tamisier, R; Tong, J; Weiss, JW; Xiang, S | 1 |
| Kim, TY; Kim, YH; Kim, YJ; Koh, JY; Lee, JY | 1 |
| Connell, BJ; Saleh, MC; Saleh, TM | 1 |
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| Bae, K; Ban, JY; Cho, SO; Choi, SH; Ju, HS; Kim, JY; Seong, YH; Song, KS | 1 |
| Chan, HH; Chu, PH; Gilger, BC; Ng, YF; Petters, RM; To, CH; Wong, F | 1 |
| Berger, SP; Brudney, EG; Johnson, SW; Meshul, CK; Paquette, MA; Putterman, DB | 1 |
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| Blumbergs, P; Cai, Z; Casson, RJ; Chotaliya, HP; Saggu, SK | 1 |
| Burnet, M; Groebe, K; Klemm, M; Poznanović, S; Proikas-Cezanne, T; Schoepf, R; Schrattenholz, A; Schwall, GP; Soskić, V; Stegmann, W; Zengerling, H | 1 |
| Barnstable, CJ; Fu, XY; Kawasaki, A; Li, H; Liu, MG; Shao-Min Zhang, S; Zhang, C | 1 |
| Hsieh, KC; Lai, YY; Nguyen, D; Peever, J; Siegel, JM | 1 |
| Beitz, AJ; Han, HJ; Kim, HW; Kim, KW; Kwon, YB; Lee, JH; Roh, DH; Seo, HS; Yoon, SY | 1 |
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| Hamberg, L; Jiang, H; Lo, EH; Matsumoto, K; Pan, Y | 1 |
| Banerjee, PK; Snead, OC | 1 |
| al-Baracanji, KA; Bailey, SJ; Barone, FC; Benham, CD; Feuerstein, G; Harries, MH; Harrison, DC; Hunter, AJ; Lysko, PG; Price, WJ | 1 |
| Ahmad, I; Pleuvry, BJ | 1 |
| Domańska-Janik, K; Lazarewicz, JW; Lukasiuk, K; Zabłocka, B | 1 |
| Gaspary, HL; Graham, SH; Simon, RP | 1 |
| Ahmad, I; Lauretti, GR; Pleuvry, BJ | 1 |
| Cannizzaro, C; Cannizzaro, G; Flugy, A; Gagliand, M; Mineo, A; Sabatino, M | 1 |
| Elben, U; Grome, JJ; Lee, GE; Lee, TB; Martin, LL; Paulus, E; Porsche-Wiebking, E; Rudolphi, KA; Rush, DK; Wilmot, CA | 1 |
| Bullock, R; Fujisawa, H; Graham, DI; Kuroda, Y; Strebel, S | 1 |
| Bardicef, M; Cotton, DB; Irtenkauf, SM; Mason, BA; Standley, CA | 1 |
| Adachi, I; Eigyo, M; Inoue, Y; Ishibashi, C; Koyabu, K; Matsushita, A; Murata, S; Sakaguchi, I; Shiomi, T; Ueda, M | 1 |
| Balázs, R; Berkelbach van der Sprenkel, JW; Nicolay, K; Tamminga, KS; Tulleken, CA; van Lookeren Campagne, M; Verheul, HB | 1 |
| Barks, JD; Nair, MP; Schwartz, SA; Silverstein, FS | 1 |
| Cotton, DB; Hallak, M; Irtenkauf, SM; Janusz, CA | 1 |
| Cheng, BH; Ho, ML; Hsu, C; Lee, JN; Li, PH; Yu, JY | 1 |
| Johnston, MV; Taylor, GA; Traystman, RJ; Trescher, WH | 1 |
| Coulter, DA; DeLorenzo, RJ; Rafiq, A; Zhang, YF | 1 |
| Bernert, H; Turski, L | 1 |
| Clapp, I; Laidlaw, S; Mitchell, IJ; Waters, CM | 1 |
| Avoli, M; Barbarosie, M; Köhling, R; Lopantsev, V; Lücke, A; Nagao, T | 1 |
| Acarin, L; Castellano, B; Castro, AJ; González, B | 1 |
| Akaike, N; Harata, N; Ishibashi, H; Nakashima, Y | 1 |
| Govindaraju, V; John, J; Kumar, VM; Raghunathan, P | 1 |
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| Depaulis, A; Deransart, C; Marescaux, C | 1 |
| Boehrer, A; Danober, L; Koerner, C; Marescaux, C; Vergnes, M | 1 |
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| Buchan, AM; Small, DL | 1 |
| Chen, AC; Chen, CH; Liu, HJ | 1 |
| Coan, EJ; Galdzicki, Z; Rapoport, SI; Siarey, RJ | 1 |
| Fischer, AJ; Seltner, RL; Stell, WK | 1 |
| Duva, CA; Floresco, SB; Lao, TL; Phillips, AG; Pinel, JP; Wunderlich, GR | 1 |
| Abou-Gharbia, M; Bramlett, DR; Garrison, DT; Kinney, WA; Kowal, DM; Miller, TL; Moyer, JA; Schmid, J; Tasse, RP; Zaleska, MM | 1 |
| Johnston, MV; McDonald, JW; Shapiro, SM; Silverstein, FS | 1 |
| Bach, M; Feuerstein, TJ; Knörle, R; Lagrèze, WA | 1 |
| Kábová, R; Velísek, L; Veresová, S | 1 |
| Barnewolt, CE; Dunning, PS; Taylor, GA | 1 |
| Dora, CD; Koch, S; Liu, S; Ruenes, G; Sanchez, A; Yezierski, RP | 1 |
| Billaud, JN; Elder, JH; Gruol, DL; Parsons, KL; Phillips, TR; Yu, N | 1 |
| Alagarsamy, S; DeWitt, DS; Johnson, KM | 1 |
| Behl, B; Hofmann, HP; Löscher, W; Potschka, H; Szabo, L; Treiber, HJ; Wlaź, P | 1 |
| Luthman, J; Oberg, C; Radesäter, AC | 1 |
| Acklin, P; Auberson, YP; Bischoff, S; Moretti, R; Ofner, S; Schmutz, M; Veenstra, SJ | 1 |
| Bittigau, P; Hübner, C; Ikonomidou, C; Ishimaru, MJ; Olney, JW; Pohl, D; Stadthaus, D; Turski, L | 1 |
| Crews, FT; Knapp, DJ | 1 |
| Brum, LF; Elisabetsky, E; Souza, DO | 1 |
| Kábová, R; Liptáková, S; Pometlová, M; Slamberová, R; Velísek, L | 1 |
| Chen, J; Li, H; Li, Z; Luo, C; Zheng, J | 1 |
| Czuczwar, SJ; Haberek, G; Kleinrok, Z; Matyska, J; Pilip, S; Tomczyk, T; Turski, WA; Urbanska, EM | 1 |
| Feldon, J; Jongen-Rêlo, AL; Pouzet, B; Weiner, I; Zhang, W | 1 |
| Hashimoto, T; Ono, Y; Saito, N; Sakai, N; Shirai, Y; Sumioka, K; Takahashi, M; Tanaka, C; Yamamoto, M | 1 |
| Galasso, JM; Martin, D; Silverstein, FS; Wang, P | 1 |
| Di Rocco, C; Di Rocco, F; Gaglini, P; Giannetti, S; Granato, A | 1 |
| Stanojlović, O; Susić, V; Zivanović, D | 1 |
| Burakgazi, E; Chalmers-Redman, R; Danias, J; Mittag, TW; Podos, SM; Pohorenec, G; Tatton, WG; Yuan, HM | 1 |
| Brotchie, JM; Nash, JE | 1 |
| Armstead, WM | 1 |
| Brusa, R; Casarini, M; Diodato, E; Grilli, M; Lozza, G; Memo, M; Ongini, E; Rozmahel, R; St George-Hyslop, P; Uberti, D; Westaway, D | 1 |
| Chizh, BA; Englberger, W; Scheede, M; Schlütz, H | 1 |
| Atapour, N; Kalantaripour, TP; Niazi, M; Nourpanah, M | 1 |
| Barnes, G; Frishman, LJ; Harwerth, RS; Li, Y; Robson, JG; Saszik, S; Smith, EL; Viswanathan, S | 1 |
| Bittigau, P; Hansen, HH; Hansen, HS; Hansen, SH; Ikonomidou, C | 1 |
| Doat, M; Rabin, RA; Winter, JC | 1 |
| Chung, JM; Gerber, G; Isaev, D; Park, SK; Randik, M | 1 |
| Delahunty, TM; Hamm, RJ; Lyeth, BG; Phillips, LL; Povlishock, JT; Temple, MD | 1 |
| Caruso, A; Castellino, FJ; Galdzicki, Z; Klein, RC; Rapoport, SI; Siarey, RJ | 1 |
| Andreassen, OA; Beal, MF; Bogdanov, MB; Dedeoglu, A; Ferrante, KL; Jenkins, BG; Kaddurah-Daouk, R | 1 |
| Basbaum, AI; Malmberg, AB; Martin, WJ | 1 |
| Diependaele, G; Govaerts, SJ; Lambert, DM; Robert, AR; Vandevoorde, S | 1 |
| Corbalán, R; Córdoba, J; Felipo, V; López-Talavera, J; Martinez, L; Monfort, P | 1 |
| Hanon, E; Klitgaard, H | 1 |
| Conway, CM; Dirig, DM; Isakson, PC; Luo, ZD; Svensson, C; Yaksh, TL | 1 |
| Giorgetti, M; Hotsenpiller, G; Teppen, T; Ward, P; Wolf, ME | 1 |
| Dehghani, F; Hailer, NP; Hischebeth, GT; Korf, HW; Roser, N; Wirjatijasa, F | 1 |
| Calderó, J; Esquerda, JE; Lladó, J; Oppenheim, RW; Tarabal, O | 1 |
| Cattaneo, E; Sipione, S | 1 |
| Ariano, MA; Calvert, CR; Cepeda, C; Chandler, SH; Flores-Hernández, J; Hayden, MR; Leavitt, BR; Levine, MS | 1 |
| Gustaw, K; Rubaj, A; Sieklucka-Dziuba, M; Zgodzinski, W | 1 |
| Brundin, P; Chen, N; Hansson, O; Hayden, MR; Leavitt, BR; Raymond, LA; Wellington, CL; Zeron, MM | 1 |
| Chen, QS; Shimahara, T; Wei, WZ; Xie, CW | 1 |
| Holmes, GL; Stafstrom, CE | 1 |
| Bomholt, SF; Bonde, C; Dagø, L; Drejer, J; Grønborg, M; Hartz, JB; Meyer, M; Møller, A; Peters, D | 1 |
| Yaksh, TL; Yamamoto, T | 1 |
| Gastard, M; Kurcewicz, I; Louvel, J; Pumain, R; Vergnes, M | 1 |
| Beal, MF; Nozaki, K | 1 |
| Backhauss, C; Karkoutly, C; Krieglstein, J; Welsch, M | 1 |
| Carlsson, A; Carlsson, M; Svensson, A | 1 |
| Backhauss, C; Karkoutly, C; Krieglstein, J; Nuglisch, J; Peruche, B; Prehn, JH; Rossberg, C | 1 |
| Oles, RJ; Singh, L; Vass, CA; Woodruff, GN | 1 |
| Ito, M; Mikawa, H; Mutoh, K; Oguro, K; Shiraishi, H; Shirasaka, Y; Tsuda, H | 1 |
| Coenen, AM; Peeters, BW; van Rijn, CM; Vossen, JM | 1 |
| Boxer, PA; Cordon, JJ; Mann, ME; Marcoux, FW; Rock, DM; Rodolosi, LC; Taylor, CP; Vartanian, MG | 1 |
| Baskys, A; Carlen, PL; Reynolds, JN | 1 |
| Anderson, WW; Clark, S; Stasheff, SF; Wilson, WA | 1 |
| Faden, AI; Simon, RP | 1 |
| Graham, DI; McCulloch, J; Nehls, DG; Park, CK; Teasdale, GM | 1 |
| Nauta, HJ; Pisharodi, M | 1 |
13 review(s) available for n-methylaspartate and Disease Models, Animal
| Article | Year |
|---|---|
NMDA neurotransmission dysfunction in mild cognitive impairment and Alzheimer's disease.
Topics: Aged; Aging; Alzheimer Disease; Animals; Brain; Cognitive Dysfunction; Disease Models, Animal; Drug Design; Humans; N-Methylaspartate; Neuronal Plasticity; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 2014 |
Neuroprotection: extrapolating from neurologic diseases to the eye.
Topics: Animals; Clinical Trials as Topic; Disease Models, Animal; Endpoint Determination; Excitatory Amino Acid Antagonists; Glaucoma, Open-Angle; Humans; Memantine; N-Methylaspartate; Nervous System Diseases; Neuroprotective Agents; Optic Nerve Diseases; Riluzole | 2009 |
Angelman syndrome: current understanding and research prospects.
Topics: Angelman Syndrome; Animals; Brain; Cerebellum; Chromosomes, Human, Pair 15; D-Aspartic Acid; Dendritic Spines; Disease Models, Animal; Electrical Synapses; gamma-Aminobutyric Acid; Gene Expression; Hippocampus; Humans; Male; N-Methylaspartate; Ubiquitin-Protein Ligases | 2009 |
The cholinergic system, sigma-1 receptors and cognition.
Topics: Acetylcholine; Aging; Animals; Brain; Calcium; Cell Differentiation; Cholinergic Fibers; Cognition; Disease Models, Animal; Glutamic Acid; Humans; N-Methylaspartate; Neurodegenerative Diseases; Neuronal Plasticity; Neurons; Psychotropic Drugs; Receptors, sigma; Sigma-1 Receptor | 2011 |
[Functional roles of constitutively active calcineurin in delayed neuronal death after brain ischemia].
Topics: Active Transport, Cell Nucleus; Animals; Brain Ischemia; Calcineurin; Calcium; Calcium Channels; Calpain; Cell Death; Cell Nucleus; Disease Models, Animal; Fas Ligand Protein; Forkhead Box Protein O1; Forkhead Transcription Factors; Mice; N-Methylaspartate; Neurons; NFATC Transcription Factors; Protein Binding; Up-Regulation | 2011 |
Brain-gut axis: from basic understanding to treatment of IBS and related disorders.
Topics: Animals; Anti-Inflammatory Agents; Disease Models, Animal; Gastrointestinal Tract; Humans; Irritable Bowel Syndrome; N-Methylaspartate; Quality of Life | 2012 |
Synaptic pathology of Down syndrome.
Topics: Animals; Chromosomes, Human, Pair 21; Disease Models, Animal; Down Syndrome; Gene Expression Regulation; Hippocampus; Humans; Long-Term Potentiation; Mice; Mice, Transgenic; Molecular Targeted Therapy; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission; Trisomy | 2012 |
Should the injured and intact hemispheres be treated differently during the early phases of physical restorative therapy in experimental stroke or parkinsonism?
Topics: Animals; Brain; Dendrites; Disease Models, Animal; Functional Laterality; N-Methylaspartate; Neuroprotective Agents; Parkinsonian Disorders; Receptors, GABA; Recovery of Function; Stroke; Synapses; Time Factors | 2003 |
The rise and fall of NMDA antagonists for ischemic stroke.
Topics: Animals; Brain Ischemia; Cell Survival; Disease Models, Animal; Excitatory Amino Acid Antagonists; Guanidines; Humans; Indoles; Ischemia; N-Methylaspartate; Neurons; Pipecolic Acids; Receptors, N-Methyl-D-Aspartate; Stroke | 2004 |
Pitfalls and hopes in Down syndrome therapeutic approaches: in the search for evidence-based treatments.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain; Disease Models, Animal; Down Syndrome; Evidence-Based Medicine; Humans; Infant; Mice; N-Methylaspartate; Phenotype | 2006 |
The role of excitatory amino acids in experimental models of Parkinson's disease.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amphetamine; Animals; Catalepsy; Disease Models, Animal; Excitatory Amino Acids; Levodopa; N-Methylaspartate; Oxidopamine; Parkinson Disease; Rats | 1994 |
NMDA antagonists: their role in neuroprotection.
Topics: Animals; Brain Ischemia; Cells, Cultured; Disease Models, Animal; Humans; N-Methylaspartate; Neurons; Neuroprotective Agents; Receptors, N-Methyl-D-Aspartate | 1997 |
Infantile spasms: criteria for an animal model.
Topics: Adrenocorticotropic Hormone; Aging; Anticonvulsants; Corticotropin-Releasing Hormone; Disease Models, Animal; Electroencephalography; Humans; Infant; N-Methylaspartate; Sleep Stages; Spasms, Infantile; Wakefulness | 2002 |
506 other study(ies) available for n-methylaspartate and Disease Models, Animal
| Article | Year |
|---|---|
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, Spinal; Humans; Mice, Inbred C57BL; Mice, Knockout; Neurons; Pruritus; Receptors, Atrial Natriuretic Factor; Reproducibility of Results; Signal Transduction; Small Molecule Libraries | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Immunocompetence; Inhibitory Concentration 50; Methacycline; Mice, Inbred C57BL; Protease Inhibitors; Quantitative Structure-Activity Relationship; Small Molecule Libraries; Vero Cells; Zika Virus; Zika Virus Infection | 2020 |
Multimodal imaging and functional analysis of the chick NMDA retinal damage model.
Topics: Animals; Chickens; Disease Models, Animal; Electroretinography; Fundus Oculi; Imaging, Three-Dimensional; Intraocular Pressure; Multimodal Imaging; N-Methylaspartate; Retina; Retinal Diseases; Tomography, Optical Coherence | 2021 |
DZNep protects against retinal ganglion cell death in an NMDA-induced mouse model of retinal degeneration.
Topics: Adenosine; Animals; Cell Count; Cell Death; Disease Models, Animal; Electroretinography; Intravitreal Injections; Male; Mice; N-Methylaspartate; Retinal Degeneration; Retinal Ganglion Cells | 2021 |
Apolipoprotein E-Containing Lipoproteins and LRP1 Protect From NMDA-Induced Excitotoxicity Associated With Reducing α2-Macroglobulin in Müller Glia.
Topics: Animals; Apolipoproteins E; Cells, Cultured; Disease Models, Animal; Ependymoglial Cells; Female; Gene Expression Regulation; Low Density Lipoprotein Receptor-Related Protein-1; Male; Mice; Mice, Inbred C57BL; N-Methylaspartate; Neuroprotective Agents; Pregnancy-Associated alpha 2-Macroglobulins; Rats; Rats, Sprague-Dawley; Retinal Degeneration; Retinal Ganglion Cells; RNA | 2021 |
CHOP deletion and anti-neuroinflammation treatment with hesperidin synergistically attenuate NMDA retinal injury in mice.
Topics: Animals; Blotting, Western; Calcium-Binding Proteins; Cytokines; Disease Models, Animal; Drug Synergism; Gene Deletion; Hesperidin; Immunohistochemistry; In Situ Nick-End Labeling; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microfilament Proteins; Microglia; N-Methylaspartate; Neuroprotection; NF-kappa B; Oxidative Stress; Real-Time Polymerase Chain Reaction; Retinal Diseases; Retinal Ganglion Cells; Transcription Factor CHOP | 2021 |
2-deoxyglucose and β-hydroxybutyrate fail to attenuate seizures in the betamethasone-NMDA model of infantile spasms.
Topics: 3-Hydroxybutyric Acid; Adrenocorticotropic Hormone; Animals; Animals, Newborn; Betamethasone; Deoxyglucose; Disease Models, Animal; Female; N-Methylaspartate; Pregnancy; Rats; Seizures; Spasm; Spasms, Infantile | 2022 |
Evaluation of crossed cerebellar diaschisis after cerebral infarction in MCAO rats based on DKI.
Topics: Animals; Apoptosis; Cerebellar Diseases; Cerebral Infarction; Diaschisis; Diffusion Tensor Imaging; Disease Models, Animal; Infarction, Middle Cerebral Artery; Male; N-Methylaspartate; Random Allocation; Rats; Rats, Sprague-Dawley | 2022 |
Anticonvulsive Effects and Pharmacokinetic Profile of Cannabidiol (CBD) in the Pentylenetetrazol (PTZ) or N-Methyl-D-Aspartate (NMDA) Models of Seizures in Infantile Rats.
Topics: Animals; Anticonvulsants; Brain; Cannabidiol; Disease Models, Animal; Epilepsy; Male; N-Methylaspartate; Pentylenetetrazole; Rats; Rats, Wistar; Seizures | 2021 |
Effects of C5a and Receptor CD88 on Glutamate and N-Methyl-D-Aspartic Acid Receptor Expression in the Mouse Model of Optic Neuromyelitis.
Topics: Animals; Disease Models, Animal; Glutamic Acid; Humans; Mice; Mice, Inbred C57BL; N-Methylaspartate; Neuromyelitis Optica; Receptor, Anaphylatoxin C5a; Spinal Cord Injuries | 2022 |
Genetic inhibition of collapsin response mediator protein-2 phosphorylation ameliorates retinal ganglion cell death in normal-tension glaucoma models.
Topics: Animals; Disease Models, Animal; Glaucoma; Glutamic Acid; Intercellular Signaling Peptides and Proteins; Mice; N-Methylaspartate; Nerve Tissue Proteins; Phosphorylation; Retinal Ganglion Cells | 2022 |
Histone Deacetylase Inhibition Restores Behavioral and Synaptic Function in a Mouse Model of 16p11.2 Deletion.
Topics: Animals; Chromosome Deletion; Disease Models, Animal; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Humans; Mice; Mice, Transgenic; N-Methylaspartate; Prefrontal Cortex; Receptors, GABA-A | 2022 |
Pridopidine Promotes Synaptogenesis and Reduces Spatial Memory Deficits in the Alzheimer's Disease APP/PS1 Mouse Model.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Disease Models, Animal; Hydrogen Peroxide; Maze Learning; Memory Disorders; Mice; Mice, Transgenic; N-Methylaspartate; Neurodegenerative Diseases; Neuroprotective Agents; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats | 2022 |
Short- and Long-Term Effects of Suboptimal Selenium Intake and Developmental Lead Exposure on Behavior and Hippocampal Glutamate Receptors in a Rat Model.
Topics: Animals; Behavior, Animal; Developmental Disabilities; Disease Models, Animal; Eating; Female; Hippocampus; Lead; Male; N-Methylaspartate; Rats; Receptors, AMPA; Receptors, Glutamate; Selenium | 2022 |
Granulocyte Colony-Stimulating Factor Improved Core Symptoms of Autism Spectrum Disorder via Modulating Glutamatergic Receptors in the Prefrontal Cortex and Hippocampus of Rat Brains.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Autism Spectrum Disorder; Brain; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Female; Granulocyte Colony-Stimulating Factor; Hippocampus; Humans; N-Methylaspartate; Neuroprotective Agents; Prefrontal Cortex; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Receptors, AMPA; Receptors, Glutamate; Risperidone; Saline Solution; Valproic Acid | 2022 |
Anti-depressant-like effect of fermented Gastrodia elata Bl. by regulating monoamine levels and BDNF/NMDAR pathways in mice.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain-Derived Neurotrophic Factor; Depression; Disease Models, Animal; Dopamine; Gastrodia; Mice; Monoamine Oxidase; N-Methylaspartate; Plant Extracts; Propane; Receptors, N-Methyl-D-Aspartate; Serotonin; Stress, Psychological | 2023 |
Sex-dependent worsening of NMDA-induced responses, anxiety, hypercortisolemia, and organometry of early peripheral immunoendocrine impairment in adult 3xTg-AD mice and their long-lasting ontogenic modulation by neonatal handling.
Topics: Alzheimer Disease; Animals; Anxiety; Corticosterone; Disease Models, Animal; Female; Male; Mice; Mice, Transgenic; N-Methylaspartate | 2023 |
Neuroprotective Effects of Transferrin in Experimental Glaucoma Models.
Topics: Animals; Disease Models, Animal; Glaucoma; Hypoxia; Intraocular Pressure; Iron; N-Methylaspartate; Neuroprotective Agents; Ocular Hypertension; Rats; Transferrin | 2022 |
Insulin-Like Growth Factor-1 Promotes Synaptogenesis Signaling, a Major Dysregulated Pathway in Malformation of Cortical Development, in a Rat Model.
Topics: Animals; Disease Models, Animal; Epilepsy; Female; Humans; Infant; Insulin-Like Growth Factor I; N-Methylaspartate; Pregnancy; Proteomics; Rats; Spasm | 2023 |
Epileptic spasms in infancy: Transferring rat prenatal betamethasone-postnatal NMDA model to mice.
Topics: Adrenocorticotropic Hormone; Animals; Betamethasone; Disease Models, Animal; Female; Mice; Mice, Inbred C57BL; N-Methylaspartate; Pregnancy; Rats; Spasms, Infantile | 2023 |
How can methylprednisolone work on epileptic spasms with malformation of cortical development?
Topics: Adrenocorticotropic Hormone; Animals; Animals, Newborn; Brain; Disease Models, Animal; Epilepsy; Female; Methylprednisolone; N-Methylaspartate; Neurogenesis; Pregnancy; Prenatal Exposure Delayed Effects; Rats | 2019 |
Furin-mediated cleavage of LRP1 and increase in ICD of LRP1 after cerebral ischemia and after exposure of cultured neurons to NMDA.
Topics: Animals; Brain Ischemia; Disease Models, Animal; Endocytosis; Furin; Humans; Low Density Lipoprotein Receptor-Related Protein-1; N-Methylaspartate; Neurodegenerative Diseases; Neurons; Rats; Receptors, LDL; Signal Transduction; Stroke; trans-Golgi Network | 2019 |
Survival of Alpha and Intrinsically Photosensitive Retinal Ganglion Cells in NMDA-Induced Neurotoxicity and a Mouse Model of Normal Tension Glaucoma.
Topics: Adaptor Proteins, Vesicular Transport; Animals; Cell Survival; Disease Models, Animal; Excitatory Amino Acid Agonists; Fluorescent Antibody Technique, Indirect; Intravitreal Injections; Light; Low Tension Glaucoma; Mice; Mice, Inbred C57BL; Mice, Knockout; Microscopy, Fluorescence; N-Methylaspartate; Optic Disk; Osteopontin; Retinal Degeneration; Retinal Ganglion Cells; RNA-Binding Proteins | 2019 |
Transplantation of Retinal Ganglion Cells Derived from Male Germline Stem Cell as a Potential Treatment to Glaucoma.
Topics: Adult Germline Stem Cells; Animals; Biomarkers; Cell Differentiation; Cell- and Tissue-Based Therapy; Disease Models, Animal; Embryonic Stem Cells; Gene Expression; Genes, Reporter; Glaucoma; Green Fluorescent Proteins; Homeodomain Proteins; Intravitreal Injections; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; N-Methylaspartate; Octamer Transcription Factor-3; Primary Cell Culture; Retina; Retinal Ganglion Cells; Testis; Transcription Factor Brn-3B | 2019 |
The neuroprotective effects of novel estrogen receptor GPER1 in mouse retinal ganglion cell degeneration.
Topics: Animals; Apoptosis; Blotting, Western; Disease Models, Animal; Gene Expression Regulation; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; N-Methylaspartate; Receptors, Estrogen; Receptors, G-Protein-Coupled; Retinal Degeneration; Retinal Ganglion Cells; RNA; Selective Estrogen Receptor Modulators; Tamoxifen | 2019 |
Regulatory role of hippocampal PI3K and mTOR signaling pathway in NMDA-induced infant spasm rats.
Topics: Animals; Cell Death; Disease Models, Animal; Female; Hippocampus; N-Methylaspartate; Phosphatidylinositol 3-Kinase; Phosphorylation; Protein Kinase Inhibitors; Rats, Sprague-Dawley; Signal Transduction; Sirolimus; Spasm; TOR Serine-Threonine Kinases; Wortmannin | 2019 |
Rod bipolar cells dysfunction occurs before ganglion cells loss in excitotoxin-damaged mouse retina.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cell Cycle Proteins; Dendrites; Disease Models, Animal; Electroretinography; Glaucoma; HEK293 Cells; Humans; Male; Mice, Inbred C57BL; N-Methylaspartate; Nerve Degeneration; Neurotoxins; Phosphorylation; Proteasome Endopeptidase Complex; Protein Binding; Protein Kinase C-alpha; Proteolysis; Receptors, N-Methyl-D-Aspartate; Retinal Bipolar Cells; Retinal Cone Photoreceptor Cells; Retinal Ganglion Cells; Retinal Rod Photoreceptor Cells; Ubiquitin | 2019 |
Simvastatin Improves Behavioral Disorders and Hippocampal Inflammatory Reaction by NMDA-Mediated Anti-inflammatory Function in MPTP-Treated Mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Anti-Inflammatory Agents; Disease Models, Animal; Dopaminergic Neurons; Hippocampus; Inflammation; Mice, Inbred C57BL; N-Methylaspartate; Neuroprotective Agents; Parkinson Disease; Simvastatin | 2020 |
Nogo-A-targeting antibody promotes visual recovery and inhibits neuroinflammation after retinal injury.
Topics: Aged; Aged, 80 and over; Amacrine Cells; Animals; Anti-Inflammatory Agents; Antibodies, Neutralizing; Diabetic Retinopathy; Disease Models, Animal; Female; Humans; Macrophages; Male; Mice, Inbred C57BL; Microglia; N-Methylaspartate; Neuronal Plasticity; Nogo Proteins; Phosphorylation; Recovery of Function; Retinal Ganglion Cells; Retinitis; Signal Transduction; STAT3 Transcription Factor; Tumor Necrosis Factor-alpha; Vision, Ocular | 2020 |
Effect of VCP modulators on gene expression profiles of retinal ganglion cells in an acute injury mouse model.
Topics: Acute Disease; Animals; Apoptosis; Biomarkers; Computational Biology; Disease Models, Animal; Disease Susceptibility; Energy Metabolism; Gene Expression Profiling; Gene Ontology; Immunophenotyping; Metabolic Networks and Pathways; Mice; N-Methylaspartate; Retinal Diseases; Retinal Ganglion Cells; Transcriptome; Valosin Containing Protein | 2020 |
Bursting interneurons in the deep dorsal horn develop increased excitability and sensitivity to serotonin after chronic spinal injury.
Topics: Action Potentials; Animals; Chronic Disease; Disease Models, Animal; Excitatory Postsynaptic Potentials; Interneurons; Mice; Mice, Inbred C57BL; Motor Neurons; N-Methylaspartate; Oxazolidinones; Posterior Horn Cells; Serotonin; Serotonin 5-HT1 Receptor Agonists; Spasm; Spinal Cord Injuries; Spinal Nerve Roots; Tryptamines | 2020 |
Early developmental electroencephalography abnormalities, neonatal seizures, and induced spasms in a mouse model of tuberous sclerosis complex.
Topics: Animals; Animals, Newborn; Arousal; Disease Models, Animal; Electroencephalography; Electromyography; Female; Male; Mice; Mice, Inbred C57BL; N-Methylaspartate; Seizures; Tuberous Sclerosis | 2020 |
Axonal Transport as an In Vivo Biomarker for Retinal Neuropathy.
Topics: Animals; Axonal Transport; Axons; Biomarkers; Disease Models, Animal; Endocytosis; Male; N-Methylaspartate; Rats, Inbred BN; Retina; Retinal Diseases; Retinal Ganglion Cells; Synapses; Tetanus Toxin | 2020 |
Astrocyte dysfunction increases cortical dendritic excitability and promotes cranial pain in familial migraine.
Topics: Animals; Astrocytes; Disease Models, Animal; Glutamic Acid; Headache; Mice; Migraine Disorders; N-Methylaspartate | 2020 |
Tyrosine triple mutated AAV2-BDNF gene therapy in an inner retinal injury model induced by intravitreal injection of
Topics: Animals; Brain-Derived Neurotrophic Factor; Dependovirus; Disease Models, Animal; Electroretinography; Gene Expression; Genetic Therapy; Genetic Vectors; Immunohistochemistry; Intravitreal Injections; Mice; Mice, Inbred C57BL; N-Methylaspartate; Recombinant Proteins; Retinal Diseases | 2020 |
Acute NMDA receptor antagonism impairs working memory performance but not attention in rats-Implications for the NMDAr hypofunction theory of schizophrenia.
Topics: Animals; Antipsychotic Agents; Attention; Cognition; Cognition Disorders; Cognitive Dysfunction; Disease Models, Animal; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Male; Memory, Short-Term; N-Methylaspartate; Rats; Rats, Wistar; Reaction Time; Receptors, N-Methyl-D-Aspartate; Schizophrenia | 2020 |
Pemafibrate prevents retinal neuronal cell death in NMDA-induced excitotoxicity via inhibition of p-c-Jun expression.
Topics: Animals; Benzoxazoles; Butyrates; Cell Death; Diabetic Retinopathy; Disease Models, Animal; JNK Mitogen-Activated Protein Kinases; Male; N-Methylaspartate; Neurons; Phosphorylation; PPAR alpha; Rats; Retina; Retinal Ganglion Cells | 2021 |
Acute D-Serine Co-Agonism of β-Cell NMDA Receptors Potentiates Glucose-Stimulated Insulin Secretion and Excitatory β-Cell Membrane Activity.
Topics: Animals; Blood Glucose; Disease Models, Animal; Female; Glucose; Glucose Intolerance; Homeostasis; Insulin Secretion; Insulin-Secreting Cells; Male; Mice, Inbred C57BL; Mice, Knockout; Models, Biological; N-Methylaspartate; Nerve Tissue Proteins; Phenotype; Receptors, N-Methyl-D-Aspartate; Serine; Sex Characteristics | 2021 |
Combined melatonin and adrenocorticotropic hormone treatment attenuates N-methyl-d-aspartate-induced infantile spasms in a rat model by regulating activation of the HPA axis.
Topics: Adrenocorticotropic Hormone; Animals; Animals, Newborn; Anticonvulsants; Disease Models, Animal; Humans; Hypothalamo-Hypophyseal System; Infant; Melatonin; N-Methylaspartate; Pituitary-Adrenal System; Rats, Sprague-Dawley; Spasms, Infantile | 2021 |
N-Substituted-3-alkoxy-derivatives of dextromethorphan are functional NMDA receptor antagonists in vivo: Evidence from an NMDA-induced seizure model in rats.
Topics: Alcohols; Animals; Anticonvulsants; Binding Sites; Dextromethorphan; Dextrorphan; Disease Models, Animal; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Infusions, Intraventricular; Ligands; Male; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, sigma; Seizures; Sigma-1 Receptor; Treatment Outcome | 2021 |
Angiotensin (1-7) Attenuates the Nociceptive Behavior Induced by Substance P and NMDA via Spinal MAS1.
Topics: Angiotensin I; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Injections, Spinal; Male; Mice; N-Methylaspartate; Nociception; Nociceptive Pain; Peptide Fragments; Proto-Oncogene Mas; Proto-Oncogene Proteins; Receptors, G-Protein-Coupled; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-1; Spinal Cord; Substance P | 2021 |
A novel cell-penetrating peptide targeting calpain-cleavage of PSD-95 induced by excitotoxicity improves neurological outcome after stroke.
Topics: Animals; Brain Ischemia; Calpain; Cell Survival; Cell-Penetrating Peptides; Cells, Cultured; Disease Models, Animal; Disks Large Homolog 4 Protein; Down-Regulation; Excitatory Amino Acid Agonists; HEK293 Cells; Humans; Male; Mice; Mice, Inbred BALB C; Movement Disorders; N-Methylaspartate; Neurons; Neuroprotection; Stroke | 2021 |
Transplantation of reprogrammed peripheral blood cells differentiates into retinal ganglion cells in the mouse eye with NMDA-induced injury.
Topics: Animals; Blood Cells; Cell Differentiation; Disease Models, Animal; Humans; Induced Pluripotent Stem Cells; Mice; N-Methylaspartate; Neurogenesis; Retina; Retinal Ganglion Cells; Stem Cell Transplantation | 2021 |
Chronic early-life social isolation affects NMDA and TrkB receptor expression in a sex-specific manner.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Female; Gene Expression Regulation; Hippocampus; Humans; Male; N-Methylaspartate; Neuronal Plasticity; Prefrontal Cortex; Rats; Receptor, trkB; Receptors, N-Methyl-D-Aspartate; Sex Factors; Social Isolation; Stress, Psychological; Time Factors | 2021 |
CYFIP1 Dosages Exhibit Divergent Behavioral Impact via Diametric Regulation of NMDA Receptor Complex Translation in Mouse Models of Psychiatric Disorders.
Topics: Adaptor Proteins, Signal Transducing; Animals; Autism Spectrum Disorder; Disease Models, Animal; DNA Copy Number Variations; Mental Disorders; Mice; Mice, Inbred C57BL; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; RNA; RNA, Messenger | 2022 |
THC-induced behavioral stereotypy in zebrafish as a model of psychosis-like behavior.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Dronabinol; N-Methylaspartate; Piperidines; Psychotic Disorders; Psychotropic Drugs; Pyrazoles; Receptor, Cannabinoid, CB1; Stereotyped Behavior; Zebrafish | 2021 |
A critical role of spinal Shank2 proteins in NMDA-induced pain hypersensitivity.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Excitatory Amino Acid Agonists; Female; Flavonoids; Hyperalgesia; Imidazoles; MAP Kinase Signaling System; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Nerve Tissue Proteins; Nociception; Pain; Pain Measurement; Protein Kinase Inhibitors; Pyridines; Spinal Cord | 2017 |
Ginsenoside Rg3 exerts anti-depressive effect on an NMDA-treated cell model and a chronic mild stress animal model.
Topics: Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Cyclic AMP Response Element-Binding Protein; Depression; Disease Models, Animal; Female; Ginsenosides; Hippocampus; Humans; Mental Disorders; Mice; Mice, Inbred C57BL; N-Methylaspartate; Neurons; Phosphorylation; Signal Transduction; Stress, Psychological | 2017 |
The activation of
Topics: Action Potentials; Animals; Calcium; Calcium Channels, L-Type; Depressive Disorder, Major; Disease Models, Animal; Dizocilpine Maleate; Heart Ventricles; Humans; Myocytes, Cardiac; N-Methylaspartate; Patch-Clamp Techniques; Potassium; Rats; Receptors, N-Methyl-D-Aspartate; Shal Potassium Channels | 2017 |
Epigenetic mechanisms underlying NMDA receptor hypofunction in the prefrontal cortex of juvenile animals in the MAM model for schizophrenia.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Cognition Disorders; Disease Models, Animal; Epigenesis, Genetic; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Female; Gene Expression Regulation, Developmental; In Vitro Techniques; Male; Methylazoxymethanol Acetate; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Prefrontal Cortex; Pregnancy; Rats; Receptors, N-Methyl-D-Aspartate; Schizophrenia | 2017 |
CDKL5 controls postsynaptic localization of GluN2B-containing NMDA receptors in the hippocampus and regulates seizure susceptibility.
Topics: Animals; Disease Models, Animal; Disease Susceptibility; Excitatory Amino Acid Antagonists; Guanylate Kinases; Hippocampus; Kainic Acid; Membrane Proteins; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Piperidines; Post-Synaptic Density; Protein Serine-Threonine Kinases; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Seizures; Tissue Culture Techniques | 2017 |
5-Hydroxytryptamine 2A receptors of the dorsal raphe nucleus modulate panic-like behaviours and mediate fear-induced antinociception elicited by neuronal activation in the central nucleus of the inferior colliculus.
Topics: Animals; Conditioning, Psychological; Disease Models, Animal; Dorsal Raphe Nucleus; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Fear; Freezing Reaction, Cataleptic; Inferior Colliculi; Male; N-Methylaspartate; Neurons; Nociception; Pain; Pain Threshold; Pyrrolidines; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT2A; Statistics, Nonparametric | 2019 |
Involvement of NMDA receptors in the antidepressant-like effect of tramadol in the mouse forced swimming test.
Topics: Animals; Antidepressive Agents; Depressive Disorder; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Agents; Ketamine; Magnesium Sulfate; Male; Mice; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Swimming; Tramadol | 2017 |
The neuroprotective effect of hesperidin in NMDA-induced retinal injury acts by suppressing oxidative stress and excessive calpain activation.
Topics: Animals; Apoptosis; Calpain; Cells, Cultured; Disease Models, Animal; Evoked Potentials, Visual; Hesperidin; Male; Mice; N-Methylaspartate; Neuroprotective Agents; Oxidative Stress; Retina; Retinal Diseases; Retinal Ganglion Cells; Treatment Outcome; Tumor Necrosis Factor-alpha | 2017 |
G protein-coupled receptor 37-like 1 modulates astrocyte glutamate transporters and neuronal NMDA receptors and is neuroprotective in ischemia.
Topics: Action Potentials; Amino Acid Transport System X-AG; Animals; Animals, Newborn; Aspartic Acid; Astrocytes; Brain; Disease Models, Animal; Exploratory Behavior; Gene Expression Regulation, Developmental; Hippocampus; Infarction, Middle Cerebral Artery; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; N-Methylaspartate; Neurons; Receptors, G-Protein-Coupled; Receptors, N-Methyl-D-Aspartate; Recognition, Psychology | 2018 |
Prenatal alcohol exposure enhances the susceptibility to NMDA-induced generalized tonic-clonic seizures in developing rats.
Topics: Aging; Animals; Binge Drinking; Disease Models, Animal; Disease Susceptibility; Female; Fetal Alcohol Spectrum Disorders; Male; N-Methylaspartate; Rats, Sprague-Dawley; Seizures; Sex Characteristics | 2017 |
Olfactory function in an excitotoxic model for secondary neuronal degeneration: Role of dopaminergic interneurons.
Topics: Animals; Brain Injuries, Traumatic; Disease Models, Animal; Dopaminergic Neurons; Interneurons; Lateral Ventricles; Magnetic Resonance Imaging; Male; N-Methylaspartate; Neurodegenerative Diseases; Neurogenesis; Neurotoxins; Olfaction Disorders; Olfactory Bulb; Rats; Rats, Sprague-Dawley | 2017 |
Inhibition of IL-1β Signaling Normalizes NMDA-Dependent Neurotransmission and Reduces Seizure Susceptibility in a Mouse Model of Creutzfeldt-Jakob Disease.
Topics: Animals; Creutzfeldt-Jakob Syndrome; Disease Models, Animal; Disease Susceptibility; Female; Hippocampus; Humans; Interleukin 1 Receptor Antagonist Protein; Interleukin-1beta; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; N-Methylaspartate; Neuronal Plasticity; Random Allocation; Receptors, N-Methyl-D-Aspartate; Seizures; Signal Transduction; Synaptic Transmission | 2017 |
Membrane cholesterol depletion in cortical neurons highlights altered NMDA receptor functionality in a mouse model of amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; beta-Cyclodextrins; Cell Membrane; Cell Survival; Cholesterol; Disease Models, Animal; Electrophysiology; Female; Glutamic Acid; Humans; Male; Membrane Microdomains; Mice; Mice, Transgenic; Motor Neurons; N-Methylaspartate; Proteomics; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Superoxide Dismutase-1 | 2018 |
Phencyclidine increased while isolation rearing did not affect progressive ratio responding in rats: Investigating potential models of amotivation in schizophrenia.
Topics: Affect; Animals; Animals, Newborn; Antipsychotic Agents; Behavior, Animal; Disease Models, Animal; Excitatory Amino Acid Antagonists; Male; Motivation; N-Methylaspartate; Phencyclidine; Rats; Rats, Long-Evans; Receptors, N-Methyl-D-Aspartate; Reward; Schizophrenia; Social Isolation | 2019 |
Retinal neuronal cell loss prevents abnormal retinal vascular growth in a rat model of retinopathy of prematurity.
Topics: Animals; Capillaries; Cell Proliferation; Disease Models, Animal; N-Methylaspartate; Phenylurea Compounds; Protein Kinase Inhibitors; Quinazolines; Rats; Rats, Sprague-Dawley; Retina; Retinal Ganglion Cells; Retinal Neurons; Retinal Vessels; Retinopathy of Prematurity; Vascular Endothelial Growth Factor A | 2018 |
MiR-93-5p targeting PTEN regulates the NMDA-induced autophagy of retinal ganglion cells via AKT/mTOR pathway in glaucoma.
Topics: Animals; Autophagy; Cell Survival; Disease Models, Animal; Female; Glaucoma; Male; MicroRNAs; N-Methylaspartate; Protein Binding; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Rats, Sprague-Dawley; Retinal Ganglion Cells; Signal Transduction; TOR Serine-Threonine Kinases; Up-Regulation | 2018 |
Paradoxical kinesia induced by appetitive 50-kHz ultrasonic vocalizations in rats depends on glutamatergic mechanisms in the inferior colliculus.
Topics: Animals; Appetitive Behavior; Catalepsy; Diazepam; Disease Models, Animal; GABA Modulators; Glutamic Acid; Haloperidol; Inferior Colliculi; Male; N-Methylaspartate; Neurotransmitter Agents; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Ultrasonics; Vocalization, Animal | 2018 |
In Vitro Assays for Mouse Müller Cell Phenotyping Through microRNA Profiling in the Damaged Retina.
Topics: Animals; Disease Models, Animal; Ependymoglial Cells; Excitatory Amino Acid Transporter 1; Gene Expression Profiling; Humans; Immunomagnetic Separation; Intravitreal Injections; Mice; Mice, Inbred C57BL; MicroRNAs; N-Methylaspartate; Real-Time Polymerase Chain Reaction; Retinal Diseases; Reverse Transcriptase Polymerase Chain Reaction | 2018 |
DAPK1-ERK signal mediates oxygen glucose deprivation reperfusion induced apoptosis in mouse N2a cells.
Topics: Animals; Apoptosis; Cell Line, Tumor; Cerebral Cortex; Cytarabine; Death-Associated Protein Kinases; Disease Models, Animal; Excitatory Amino Acid Agonists; Glucose; Glycine; Hypoxia; Immunosuppressive Agents; Infarction, Middle Cerebral Artery; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; N-Methylaspartate; Neuroblastoma; Neurons; Protein Biosynthesis; RNA, Small Interfering | 2018 |
Injecting NMDA and Ro 25-6981 in insular cortex induce neuroplastic changes and neuropathic pain-like behaviour.
Topics: Animals; Central Nervous System Sensitization; Cerebral Cortex; Disease Models, Animal; Electric Stimulation; Excitatory Amino Acid Agonists; Male; N-Methylaspartate; Neural Cell Adhesion Molecule L1; Neuralgia; Neuronal Plasticity; Pain Threshold; Phenols; Piperidines; Rats; Rats, Sprague-Dawley; Sialic Acids | 2018 |
Improvement of symptoms in a rat model of depression through combined zinc and folic acid administration via up-regulation of the Trk B and NMDA.
Topics: Animals; Brain; Depression; Disease Models, Animal; Drug Therapy, Combination; Folic Acid; Male; N-Methylaspartate; Random Allocation; Rats; Rats, Sprague-Dawley; Receptor Protein-Tyrosine Kinases; Up-Regulation; Zinc | 2018 |
Targeting VGLUT2 in Mature Dopamine Neurons Decreases Mesoaccumbal Glutamatergic Transmission and Identifies a Role for Glutamate Co-release in Synaptic Plasticity by Increasing Baseline AMPA/NMDA Ratio.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amphetamine; Animals; Behavior, Animal; Cocaine; Disease Models, Animal; Dopamine Agents; Dopaminergic Neurons; Glutamic Acid; Mice; Mice, Transgenic; N-Methylaspartate; Neuronal Plasticity; Nucleus Accumbens; Optogenetics; Patch-Clamp Techniques; Receptors, Dopamine D1; Substance-Related Disorders; Synaptic Transmission; Ventral Tegmental Area; Vesicular Glutamate Transport Protein 2 | 2018 |
Cannabidiol enhances morphine antinociception, diminishes NMDA-mediated seizures and reduces stroke damage via the sigma 1 receptor.
Topics: Animals; Anticonvulsants; Cannabidiol; Disease Models, Animal; Infarction, Middle Cerebral Artery; Male; Mice, Knockout; Morphine; N-Methylaspartate; Nociception; Protein Subunits; Receptors, N-Methyl-D-Aspartate; Receptors, sigma; Seizures; Sigma-1 Receptor; Stroke | 2018 |
Anti-N-Methyl-D-Aspartic Acid Receptor 2 (Anti-NR2) Antibody in Neuropsychiatric Lupus Serum Damages the Blood-Brain Barrier and Enters the Brain.
Topics: Animals; Autoantibodies; Biological Transport; Blood-Brain Barrier; Brain; Capillary Permeability; China; Disease Models, Animal; Electric Impedance; Endothelial Cells; Extracellular Space; Female; Glutamic Acid; Lupus Vasculitis, Central Nervous System; Male; Microvessels; N-Methylaspartate; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 2019 |
Insulin-like growth factor 1 promotes cochlear synapse regeneration after excitotoxic trauma in vitro.
Topics: Animals; Cochlea; Disease Models, Animal; Hair Cells, Auditory, Inner; Hearing Loss, Sensorineural; Humans; In Vitro Techniques; Insulin-Like Growth Factor I; Kainic Acid; Mice; Mice, Inbred ICR; N-Methylaspartate; Nerve Regeneration; Ototoxicity; Receptor, IGF Type 1; Spiral Ganglion; Synapses | 2019 |
AQB-565 shows promise in preclinical testing in the model of epileptic spasms during infancy: Head-to-head comparison with ACTH.
Topics: Adrenocorticotropic Hormone; Age Factors; Analysis of Variance; Animals; Animals, Newborn; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalography; Excitatory Amino Acid Agonists; Female; Humans; Infant; Male; Melanocyte-Stimulating Hormones; N-Methylaspartate; Peptides; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Spasms, Infantile; Treatment Outcome | 2019 |
Involvement of matrix metalloproteinases in capillary degeneration following NMDA-induced neurotoxicity in the neonatal rat retina.
Topics: Animals; Animals, Newborn; Blotting, Western; Capillaries; Disease Models, Animal; Matrix Metalloproteinase 9; N-Methylaspartate; Rats, Sprague-Dawley; Retinal Degeneration; Retinal Ganglion Cells; Retinal Vessels | 2019 |
The protective effect of oleanolic acid on NMDA-induced MLE-12 cells apoptosis and lung injury in mice by activating SIRT1 and reducing NF-κB acetylation.
Topics: Acetylation; Acute Lung Injury; Animals; Anti-Inflammatory Agents; Apoptosis; Cell Line; Disease Models, Animal; Gene Expression Regulation; Humans; Male; Mice; Mice, Inbred BALB C; N-Methylaspartate; NF-kappa B; Oleanolic Acid; Oxidative Stress; Respiratory Mucosa; Sirtuin 1 | 2019 |
Evaluation of brain SERT with 4-[
Topics: Animals; Benzylamines; Brain; Brain Stem; Dextromethorphan; Disease Models, Animal; Evoked Potentials, Auditory, Brain Stem; Hearing Loss; Male; N-Methylaspartate; Positron-Emission Tomography; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; RNA-Binding Proteins; Serotonergic Neurons; Serotonin Plasma Membrane Transport Proteins | 2019 |
Effect of memantine hydrochloride on cisplatin-induced neurobehavioral toxicity in mice.
Topics: Animals; Antineoplastic Agents; Behavior, Animal; Cisplatin; Disease Models, Animal; Excitatory Amino Acid Antagonists; Male; Memantine; Mice, Inbred BALB C; N-Methylaspartate; Neuroprotective Agents; Neurotoxicity Syndromes; Psychomotor Performance | 2020 |
Endoplasmic reticulum stress contributes to NMDA-induced pancreatic β-cell dysfunction in a CHOP-dependent manner.
Topics: Activating Transcription Factor 4; Animals; Apoptosis; Cell Line; Diabetes Mellitus, Experimental; Disease Models, Animal; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Glucose; Heat-Shock Proteins; Insulin; Insulin Secretion; Insulin-Secreting Cells; Male; Mice; Mice, Inbred BALB C; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Transcription Factor CHOP; X-Box Binding Protein 1 | 2019 |
Inhibition of a SNARE-sensitive pathway in astrocytes attenuates damage following stroke.
Topics: Animals; Astrocytes; Brain Infarction; Disease Models, Animal; Excitatory Amino Acid Agonists; Gene Expression Regulation; Green Fluorescent Proteins; Intracranial Thrombosis; Locomotion; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; N-Methylaspartate; Neurons; Phosphopyruvate Hydratase; Psychomotor Performance; Signal Transduction; SNARE Proteins; Stroke | 2013 |
Shift from extracellular signal-regulated kinase to AKT/cAMP response element-binding protein pathway increases survival-motor-neuron expression in spinal-muscular-atrophy-like mice and patient cells.
Topics: Animals; Animals, Newborn; Butadienes; Calcium; Cell Survival; Cells, Cultured; Chromatin Immunoprecipitation; Coculture Techniques; Cyclic AMP Response Element-Binding Protein; Disease Models, Animal; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Exploratory Behavior; Extracellular Signal-Regulated MAP Kinases; Female; Ganglia, Spinal; Humans; Male; Mice; Mice, Knockout; Motor Neurons; Muscle Cells; Muscular Atrophy, Spinal; N-Methylaspartate; Nitriles; Signal Transduction; Stem Cells; Survival of Motor Neuron 2 Protein | 2013 |
SPARC regulates microgliosis and functional recovery following cortical ischemia.
Topics: Age Factors; Animals; Animals, Newborn; Brain Infarction; Brain Ischemia; Calcium-Binding Proteins; Cell Count; Cell Movement; Cell Proliferation; Cell Size; Cells, Cultured; Cerebral Cortex; CX3C Chemokine Receptor 1; Disease Models, Animal; Excitatory Amino Acid Agonists; Female; Forelimb; Galectin 3; Gene Expression Regulation, Developmental; Genotype; Glial Fibrillary Acidic Protein; Gliosis; Glycoproteins; Green Fluorescent Proteins; Intracranial Thrombosis; Lectins; Male; Mice; Mice, Transgenic; Microfilament Proteins; Microglia; Motor Skills; Mutation; N-Methylaspartate; NF-kappaB-Inducing Kinase; Olfactory Bulb; Osteonectin; Proliferating Cell Nuclear Antigen; Protein Serine-Threonine Kinases; Receptors, Chemokine; Recovery of Function; Time Factors; Tumor Suppressor Proteins | 2013 |
Conditional disruption of calpain in the CNS alters dendrite morphology, impairs LTP, and promotes neuronal survival following injury.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Age Factors; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analysis of Variance; Animals; Animals, Newborn; Biophysics; Brain; Brain Injuries; Bromodeoxyuridine; Calpain; Cell Death; Dendrites; Disease Models, Animal; Electric Stimulation; Embryo, Mammalian; Evoked Potentials; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Female; Gene Expression Regulation, Developmental; Green Fluorescent Proteins; Hippocampus; In Vitro Techniques; Intermediate Filament Proteins; Long-Term Potentiation; Male; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Transgenic; N-Methylaspartate; Nerve Tissue Proteins; Nestin; Neurons; Patch-Clamp Techniques; Phosphotransferases; Psychomotor Performance; RNA, Messenger; Silver Staining; Transfection; Tyrosine 3-Monooxygenase | 2013 |
Involvement of the nucleus accumbens shell dopaminergic system in prelimbic NMDA-induced anxiolytic-like behaviors.
Topics: Animals; Anxiety; Behavior, Animal; Disease Models, Animal; Dopamine; Dopamine Agonists; Dopamine Antagonists; Dopaminergic Neurons; Dose-Response Relationship, Drug; Exploratory Behavior; Injections, Intraventricular; Male; N-Methylaspartate; Nerve Tissue Proteins; Nucleus Accumbens; Protein Isoforms; Random Allocation; Rats; Rats, Wistar; Receptors, Dopamine | 2013 |
Imbalance of p75(NTR)/TrkB protein expression in Huntington's disease: implication for neuroprotective therapies.
Topics: Animals; Apoptosis; Brain-Derived Neurotrophic Factor; Cell Line; Corpus Striatum; Disease Models, Animal; Enzyme Inhibitors; Gene Knock-In Techniques; Humans; Huntingtin Protein; Huntington Disease; JNK Mitogen-Activated Protein Kinases; Mice; N-Methylaspartate; Nerve Tissue Proteins; Nuclear Proteins; Okadaic Acid; Phosphorylation; Protein Binding; Protein Phosphatase 1; Proto-Oncogene Proteins c-akt; Putamen; Receptor, Nerve Growth Factor; Receptor, trkB; RNA Interference; RNA, Small Interfering; Signal Transduction | 2013 |
Critical role of increased PTEN nuclear translocation in excitotoxic and ischemic neuronal injuries.
Topics: Animals; Brain; Brain Ischemia; Cells, Cultured; Disease Models, Animal; Embryo, Mammalian; Excitatory Amino Acid Agonists; Female; Fluorodeoxyglucose F18; Green Fluorescent Proteins; L-Lactate Dehydrogenase; Male; Mice; Mutation; N-Methylaspartate; Nervous System Diseases; Neurons; Nuclear Localization Signals; Peptides; Pregnancy; Protein Transport; PTEN Phosphohydrolase; Radionuclide Imaging; Rats; Rats, Sprague-Dawley | 2013 |
Defective synaptic transmission and structure in the dentate gyrus and selective fear memory impairment in the Rsk2 mutant mouse model of Coffin-Lowry syndrome.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Coffin-Lowry Syndrome; Conditioning, Psychological; Cues; Dentate Gyrus; Disease Models, Animal; Electric Stimulation; Excitatory Postsynaptic Potentials; Fear; Freezing Reaction, Cataleptic; In Vitro Techniques; Memory Disorders; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microscopy, Electron, Transmission; Mutation; N-Methylaspartate; Nerve Tissue Proteins; Ribosomal Protein S6 Kinases, 90-kDa; Synapses; Synaptic Transmission | 2013 |
Contribution of N-methyl-DL-aspartic acid (NMDA)-sensitive neurons to generating oscillatory potentials in Royal College of Surgeons rats.
Topics: Animals; Dark Adaptation; Disease Models, Animal; Electroretinography; Intravitreal Injections; N-Methylaspartate; Oscillometry; Photic Stimulation; Photoreceptor Cells, Vertebrate; Rats; Rats, Mutant Strains; Retinal Degeneration; Retinal Neurons | 2013 |
Enhanced NMDA receptor-mediated intracellular calcium signaling in magnocellular neurosecretory neurons in heart failure rats.
Topics: Action Potentials; Animals; Calcium Signaling; Disease Models, Animal; Excitatory Amino Acid Agonists; Feedback, Physiological; Heart Failure; Hypothalamus; Male; Microscopy, Confocal; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Time Factors | 2013 |
Dock3 attenuates neural cell death due to NMDA neurotoxicity and oxidative stress in a mouse model of normal tension glaucoma.
Topics: Animals; Apoptosis; Binding Sites; Carrier Proteins; Cell Line; Disease Models, Animal; Excitatory Amino Acid Transporter 1; Glutamic Acid; Guanine Nucleotide Exchange Factors; HEK293 Cells; Humans; Low Tension Glaucoma; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Oxidative Stress; Phosphorylation; Protein Binding; Receptors, N-Methyl-D-Aspartate; Retina; Retinal Degeneration; Retinal Ganglion Cells; Signal Transduction | 2013 |
Discovery of novel (1S)-(-)-verbenone derivatives with anti-oxidant and anti-ischemic effects.
Topics: Animals; Antioxidants; Bicyclic Monoterpenes; Cells, Cultured; Disease Models, Animal; Drug Discovery; Ischemia; N-Methylaspartate; Neurons; Neuroprotective Agents; Oxidative Stress; Terpenes | 2013 |
Trafficking of NMDA receptors during status epilepticus: therapeutic implications.
Topics: Animals; Disease Models, Animal; Hippocampus; N-Methylaspartate; Neurons; Rats; Receptors, N-Methyl-D-Aspartate; Status Epilepticus | 2013 |
β-amyloid impairs the regulation of N-methyl-D-aspartate receptors by glycogen synthase kinase 3.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Apoptosis; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; Glycogen Synthase Kinase 3; Indoles; Male; Maleimides; Mice; Mice, Transgenic; Molecular Targeted Therapy; N-Methylaspartate; Neuronal Plasticity; Neurons; rab5 GTP-Binding Proteins; Rats; Receptors, N-Methyl-D-Aspartate | 2014 |
Thiamine deficiency induces massive cell death in the olfactory bulbs of mice.
Topics: Animals; Antimetabolites; Calcium-Binding Proteins; Caspase 3; Cell Death; Disease Models, Animal; DNA, Single-Stranded; In Situ Nick-End Labeling; Male; Mice; Mice, Inbred DBA; Microfilament Proteins; Microglia; N-Methylaspartate; Neurons; Olfactory Bulb; Pyrithiamine; Thiamine; Thiamine Deficiency | 2013 |
Autoregulation of retinal blood flow in response to decreased ocular perfusion pressure in cats: comparison of the effects of increased intraocular pressure and systemic hypotension.
Topics: Adenosine; Animals; Cats; Disease Models, Animal; Endothelium-Dependent Relaxing Factors; Excitatory Amino Acid Agonists; Female; Homeostasis; Hypotension; Intraocular Pressure; Intravitreal Injections; Laser-Doppler Flowmetry; Male; N-Methylaspartate; Nitric Oxide; Ocular Hypertension; Regional Blood Flow; Retina; Vasodilator Agents | 2014 |
An automated maze task for assessing hippocampus-sensitive memory in mice.
Topics: Analysis of Variance; Animals; Disease Models, Animal; Electronic Data Processing; Excitatory Amino Acid Agonists; Hippocampus; Male; Maze Learning; Memory Disorders; Mice; Mice, Inbred C57BL; N-Methylaspartate; Reaction Time; Reward | 2014 |
Decreasing Levels of the cdk5 Activators, p25 and p35, Reduces Excitotoxicity in Striatal Neurons.
Topics: Analysis of Variance; Animals; Corpus Striatum; Disease Models, Animal; Huntington Disease; Mice; Mice, Transgenic; N-Methylaspartate; Neurons; Neurotoxins; Phosphotransferases | 2012 |
Neuronal and nonneuronal COX-2 expression confers neurotoxic and neuroprotective phenotypes in response to excitotoxin challenge.
Topics: Analysis of Variance; Animals; Antigens, Differentiation; Cyclooxygenase 2; Disease Models, Animal; Gene Expression Regulation; Glycine; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Neurons; Neuroprotective Agents; Neurotoxicity Syndromes; Neurotoxins; Phosphopyruvate Hydratase; Tetrazoles | 2014 |
NMDA receptor activation antagonizes the NMDA antagonist-induced antianxiety effect in the elevated plus-maze test in mice.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Binding Sites; Brain; Disease Models, Animal; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Ligands; Male; Maze Learning; Mice; N-Methylaspartate; Quinolones; Receptors, N-Methyl-D-Aspartate; Serine | 2013 |
Hydroxycinnamic acids in Crepidiastrum denticulatum protect oxidative stress-induced retinal damage.
Topics: Animals; Apoptosis; Asteraceae; Caffeic Acids; Chlorogenic Acid; Coumaric Acids; Disease Models, Animal; Glaucoma; Lipid Peroxidation; Male; Mice; Mice, Inbred ICR; N-Methylaspartate; Nerve Crush; Neuroprotective Agents; Optic Nerve; Oxidative Stress; Plant Extracts; Rats; Rats, Sprague-Dawley; Retinal Diseases; Succinates | 2014 |
Antihyperalgesic effects of ginseng total saponins in a rat model of incisional pain.
Topics: Acute Pain; Animals; Disease Models, Animal; Excitatory Amino Acid Agonists; Hyperalgesia; Injections, Intraperitoneal; Male; N-Methylaspartate; Naloxone; Narcotic Antagonists; Pain, Postoperative; Panax; Rats; Rats, Sprague-Dawley; Saponins | 2014 |
Progressive brain damage, synaptic reorganization and NMDA activation in a model of epileptogenic cortical dysplasia.
Topics: Animals; Atrophy; Cerebral Cortex; Disease Models, Animal; Epilepsies, Partial; Female; Hippocampus; Malformations of Cortical Development; N-Methylaspartate; Neocortex; Pregnancy; Pyramidal Cells; Rats; Receptors, N-Methyl-D-Aspartate; Synapses | 2014 |
Differential neuroprotective effects of 5'-deoxy-5'-methylthioadenosine.
Topics: Acute Disease; Adrenergic Antagonists; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Blood-Brain Barrier; Brain Ischemia; Cell Membrane Permeability; Cells, Cultured; Chronic Disease; Deoxyadenosines; Disease Models, Animal; Glucose; Male; Mice; N-Methylaspartate; Nerve Degeneration; Neuroprotective Agents; Neurotoxins; Oxygen; Pilocarpine; Rats; Rats, Sprague-Dawley; Rats, Wistar; Status Epilepticus; Thionucleosides | 2014 |
Müller cells and microglia of the mouse eye react throughout the entire retina in response to the procedure of an intravitreal injection.
Topics: Animals; Disease Models, Animal; Ependymoglial Cells; Excitatory Amino Acid Agonists; Gliosis; Intravitreal Injections; Mice; Mice, Inbred Strains; Microglia; N-Methylaspartate; Retina; Retinal Diseases | 2014 |
Striatal synaptic dysfunction and hippocampal plasticity deficits in the Hu97/18 mouse model of Huntington disease.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; CA1 Region, Hippocampal; Cell Membrane; Disease Models, Animal; Excitatory Postsynaptic Potentials; Hippocampus; Humans; Huntington Disease; Long-Term Potentiation; Mice; Mice, Transgenic; N-Methylaspartate; Neostriatum; Neuronal Plasticity; Neurons; Pyramidal Cells; Synapses | 2014 |
Transient inactivation of the ventral hippocampus in neonatal rats impairs the mesolimbic regulation of prefrontal glutamate release in adulthood.
Topics: Animals; Animals, Newborn; Catheters, Indwelling; Disease Models, Animal; Electrodes, Implanted; Glutamic Acid; Hippocampus; Male; Microelectrodes; N-Methylaspartate; Nucleus Accumbens; Prefrontal Cortex; Rats, Wistar; Schizophrenia; Sodium Channel Blockers; Tetrodotoxin | 2014 |
Contrasting forms of cocaine-evoked plasticity control components of relapse.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dopaminergic Neurons; Drug-Seeking Behavior; Female; Hippocampus; Male; Mice; N-Methylaspartate; Neural Pathways; Neuronal Plasticity; Nucleus Accumbens; Optogenetics; Prefrontal Cortex; Receptors, AMPA; Receptors, Dopamine D1; Recurrence; Synapses | 2014 |
Environmental enrichment restores CA1 hippocampal LTP and reduces severity of seizures in epileptic mice.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analysis of Variance; Animals; Animals, Newborn; Biophysics; CA1 Region, Hippocampal; Disease Models, Animal; Electric Stimulation; Environment; Epilepsy; Excitatory Amino Acid Agonists; In Vitro Techniques; Long-Term Potentiation; Mice; Mice, Transgenic; Mutation; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Patch-Clamp Techniques | 2014 |
Role of glutamate and advantages of combining memantine with a 5HT6 ligand in a model of depression.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Depression; Disease Models, Animal; Glutamic Acid; Ligands; Male; Memantine; Motor Activity; N-Methylaspartate; Piperazines; Prefrontal Cortex; Rats; Rats, Wistar; Serotonin; Serotonin Antagonists; Sulfonamides; Swimming | 2014 |
Neuroprotective effects of C3 exoenzyme in excitotoxic retinopathy.
Topics: ADP Ribose Transferases; Analysis of Variance; Animals; Apoptosis; Botulinum Toxins; Cell Survival; Disease Models, Animal; Intravitreal Injections; Male; Mice; N-Methylaspartate; Neuroprotective Agents; NIH 3T3 Cells; Rats; Rats, Sprague-Dawley; Retina; Retinal Diseases; Retinal Ganglion Cells; rhoA GTP-Binding Protein | 2014 |
Age-dependent changes in the severity of capillary degeneration in rat retina following N-methyl-D-aspartate-induced neurotoxicity.
Topics: Animals; Capillaries; Cell Death; Disease Models, Animal; Male; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Retinal Degeneration; Retinal Ganglion Cells; Severity of Illness Index | 2015 |
Proteomic analysis on infantile spasm and prenatal stress.
Topics: 14-3-3 Proteins; Animals; Cofilin 1; Computational Biology; Disease Models, Animal; Excitatory Amino Acid Agonists; Female; Humans; Infant; Male; Molecular Chaperones; N-Methylaspartate; Pregnancy; Prenatal Exposure Delayed Effects; Protein Interaction Maps; Proteomics; Rats; Rats, Wistar; Spasms, Infantile; Stress, Psychological; Two-Dimensional Difference Gel Electrophoresis | 2014 |
Elevated intracranial dopamine impairs the glutamate‑nitric oxide‑cyclic guanosine monophosphate pathway in cortical astrocytes in rats with minimal hepatic encephalopathy.
Topics: Animals; Astrocytes; Behavior, Animal; Calmodulin; Cerebral Cortex; Cyclic GMP; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Glial Fibrillary Acidic Protein; Glutamates; Guanylate Cyclase; Hepatic Encephalopathy; Memory; N-Methylaspartate; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Soluble Guanylyl Cyclase | 2014 |
Dentate gyrus-CA3 glutamate release/NMDA transmission mediates behavioral despair and antidepressant-like responses to leptin.
Topics: Animals; Antidepressive Agents; CA3 Region, Hippocampal; Dentate Gyrus; Depression; Disease Models, Animal; Enzyme Inhibitors; Excitatory Amino Acid Agents; Gene Expression Regulation; Glutamic Acid; Leptin; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Motor Activity; N-Methylaspartate; Receptors, Leptin; RNA, Untranslated; Synapses; Synaptic Transmission; Wakefulness | 2015 |
Region- and age-dependent reductions of hippocampal long-term potentiation and NMDA to AMPA ratio in a genetic model of Alzheimer's disease.
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Cholinesterase Inhibitors; Disease Models, Animal; Hippocampus; Long-Term Potentiation; Mice, Transgenic; Molecular Targeted Therapy; Mutation; N-Methylaspartate; Neostigmine; Plaque, Amyloid | 2015 |
Effects of D-penicillamine on pentylenetetrazole-induced seizures in mice: involvement of nitric oxide/NMDA pathways.
Topics: Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Male; Mice; N-Methylaspartate; Nitric Oxide; Nitric Oxide Synthase; Penicillamine; Pentylenetetrazole; Seizures; Signal Transduction | 2014 |
Memantine delayed N-methyl-D-aspartate -induced convulsions in neonatal rats.
Topics: Animals; Animals, Newborn; Disease Models, Animal; Female; Male; Memantine; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Seizures | 2015 |
Deranged NMDAergic cortico-subthalamic transmission underlies parkinsonian motor deficits.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Electrophysiological Phenomena; Excitatory Amino Acid Antagonists; Locomotion; Male; Mice; Motor Cortex; Motor Skills; N-Methylaspartate; Parkinson Disease; Rats; Rats, Wistar; Receptors, Glutamate; Subthalamic Nucleus | 2014 |
A potential effect of ganaxolone in an animal model of infantile spasms.
Topics: Age Factors; Anesthetics; Animals; Animals, Newborn; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalography; Excitatory Amino Acid Agonists; Exploratory Behavior; Female; Humans; Infant; Male; N-Methylaspartate; Pregnanolone; Rats; Rats, Sprague-Dawley; Reaction Time; Social Behavior; Spasms, Infantile; Statistics, Nonparametric | 2014 |
Reactive retinal microglia, neuronal survival, and the formation of retinal folds and detachments.
Topics: Age Factors; Animals; Animals, Newborn; Cell Death; Chickens; Clodronic Acid; Disease Models, Animal; Excitatory Amino Acid Agonists; In Situ Nick-End Labeling; Interleukin-6; Leukocyte Common Antigens; Liposomes; Macrophages; Microglia; N-Methylaspartate; Neurons; Plant Lectins; Retina; Retinal Detachment; SOX9 Transcription Factor | 2015 |
Heterozygote Wdr36-deficient mice do not develop glaucoma.
Topics: Alleles; Animals; Axons; Blotting, Northern; Disease Models, Animal; Eye Proteins; Gene Expression Regulation; Glaucoma, Open-Angle; Intraocular Pressure; Loss of Heterozygosity; Mice; Mice, Inbred C57BL; Mice, Transgenic; N-Methylaspartate; Optic Nerve Diseases; Phenotype; Real-Time Polymerase Chain Reaction; Retinal Ganglion Cells; Risk Factors; RNA, Messenger; Tonometry, Ocular | 2014 |
Regression of retinal capillaries following N-methyl-D-aspartate-induced neurotoxicity in the neonatal rat retina.
Topics: Age Factors; Animals; Animals, Newborn; Capillaries; Collagen Type IV; Disease Models, Animal; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Gene Expression Regulation, Developmental; Male; N-Methylaspartate; Neurotoxicity Syndromes; Phenylurea Compounds; Plant Lectins; Quinazolines; Rats; Rats, Sprague-Dawley; Rec A Recombinases; Retinal Degeneration; Statistics, Nonparametric; Vascular Endothelial Growth Factor A | 2015 |
Sigma-1 (σ₁) receptor deficiency reduces β-amyloid(25-35)-induced hippocampal neuronal cell death and cognitive deficits through suppressing phosphorylation of the NMDA receptor NR2B.
Topics: Amyloid beta-Peptides; Animals; Apoptosis; Cell Death; Cognition Disorders; Disease Models, Animal; Excitatory Amino Acid Agents; Hippocampus; Male; Maze Learning; Membrane Potentials; Mice; Mice, Knockout; N-Methylaspartate; Neurons; Peptide Fragments; Phosphorylation; Reaction Time; Receptors, N-Methyl-D-Aspartate; Receptors, sigma; Sigma-1 Receptor; Spatial Memory; Time Factors | 2015 |
Age-dependent neuroprotection of retinal ganglion cells by tempol-C8 acyl ester in a rat NMDA toxicity model.
Topics: Aging; Animals; Cyclic N-Oxides; Disease Models, Animal; Excitatory Amino Acid Agonists; N-Methylaspartate; Neuroprotective Agents; Rats; Retinal Ganglion Cells; Spin Labels | 2014 |
Glycine transporters type 1 inhibitor promotes brain preconditioning against NMDA-induced excitotoxicity.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Excitatory Amino Acid Agonists; Fluoresceins; Gas Chromatography-Mass Spectrometry; Gene Expression Regulation; Glutamic Acid; Glycine; Glycine Plasma Membrane Transport Proteins; Hippocampus; Male; Mice; Mice, Inbred C57BL; N-Methylaspartate; Neurotoxicity Syndromes; Sarcosine; Time Factors; Tritium | 2015 |
Anti-aversive role of the endocannabinoid system in the periaqueductal gray stimulation model of panic attacks in rats.
Topics: Amidohydrolases; Animals; Anxiety; Arachidonic Acids; Behavior, Animal; Benzamides; Carbamates; Disease Models, Animal; Endocannabinoids; Enzyme Inhibitors; Male; N-Methylaspartate; Panic Disorder; Periaqueductal Gray; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1 | 2015 |
Investigating glutamatergic mechanism in attention and impulse control using rats in a modified 5-choice serial reaction time task.
Topics: Amino Acids; Animals; Attention; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Impulsive Behavior; Male; N-Methylaspartate; Prefrontal Cortex; Rats; Reaction Time; Xanthenes | 2014 |
Neurochemical excitation of thoracic propriospinal neurons improves hindlimb stepping in adult rats with spinal cord lesions.
Topics: Animals; Disease Models, Animal; Excitatory Amino Acid Agonists; Female; Functional Laterality; Gait Disorders, Neurologic; Hindlimb; N-Methylaspartate; Neurotransmitter Agents; Quipazine; Rats; Rats, Sprague-Dawley; Sensory Receptor Cells; Serotonin Receptor Agonists; Spinal Cord; Spinal Cord Injuries; Stimulation, Chemical; Time Factors | 2015 |
Participation of NMDA receptors in the lateral hypothalamus in gastric erosion induced by cold-water restraint.
Topics: Analysis of Variance; Animals; Cold Temperature; Disease Models, Animal; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Hypothalamic Area, Lateral; Male; N-Methylaspartate; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Restraint, Physical; Stomach Ulcer; Valine | 2015 |
μ-Opioid and N-methyl-D-aspartate receptors in the amygdala contribute to minocycline-induced potentiation of morphine analgesia in rats.
Topics: Amygdala; Analgesics; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Excitatory Amino Acid Agonists; Hot Temperature; Injections, Intraperitoneal; Male; Minocycline; Morphine; N-Methylaspartate; Naloxone; Narcotic Antagonists; Pain; Pain Measurement; Random Allocation; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, mu | 2015 |
Loss of the preferential control over the striato-nigral direct pathway by striatal NMDA receptors in a rat model of Parkinson's disease.
Topics: Animals; Disease Models, Animal; gamma-Aminobutyric Acid; Globus Pallidus; Male; Microdialysis; N-Methylaspartate; Neostriatum; Parkinson Disease; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Substantia Nigra | 2015 |
Activation of liver X receptor protects inner retinal damage induced by N-methyl-D-aspartate.
Topics: Animals; Apoptosis; Blotting, Western; Disease Models, Animal; Electroretinography; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation; Immunohistochemistry; In Situ Nick-End Labeling; Liver X Receptors; Mice; Mice, Inbred C57BL; N-Methylaspartate; Orphan Nuclear Receptors; Real-Time Polymerase Chain Reaction; Retina; Retinal Diseases; RNA, Messenger | 2015 |
Anemoside A3 Enhances Cognition through the Regulation of Synaptic Function and Neuroprotection.
Topics: Animals; Cognition; Disease Models, Animal; Escape Reaction; Excitatory Postsynaptic Potentials; Exploratory Behavior; Hippocampus; In Vitro Techniques; Infarction, Middle Cerebral Artery; MAP Kinase Signaling System; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; N-Methylaspartate; Nerve Net; Neuroprotective Agents; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Saponins; Spatial Navigation; Synapses; Triterpenes | 2015 |
Identification of p58IPK as a novel neuroprotective factor for retinal neurons.
Topics: Animals; Apoptosis; Cell Survival; Cells, Cultured; Disease Models, Animal; Endoplasmic Reticulum Stress; Gene Expression Regulation; HSP40 Heat-Shock Proteins; Immunoblotting; In Situ Nick-End Labeling; Mice; Mice, Knockout; N-Methylaspartate; Neurons; Real-Time Polymerase Chain Reaction; Retinal Diseases; Retinal Ganglion Cells; RNA | 2015 |
Characterization of a Synthetic Steroid 24-keto-cholest-5-en-3β, 19-diol as a Neuroprotectant.
Topics: Animals; Animals, Newborn; Calcium; Cell Hypoxia; Cells, Cultured; Cerebellum; Cholestanols; Disease Models, Animal; Excitatory Amino Acid Agonists; Glutamic Acid; Infarction, Middle Cerebral Artery; L-Lactate Dehydrogenase; N-Methylaspartate; Neurons; Neuroprotective Agents; Oxygen; Rats; Rats, Sprague-Dawley | 2015 |
The dual effect of CA1 NMDA receptor modulation on ACPA-induced amnesia in step-down passive avoidance learning task.
Topics: 2-Amino-5-phosphonovalerate; Amnesia; Analysis of Variance; Animals; Arachidonic Acids; Avoidance Learning; CA1 Region, Hippocampal; Cannabinoid Receptor Agonists; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Excitatory Amino Acid Antagonists; Exploratory Behavior; Male; Mice; Microinjections; N-Methylaspartate; Piperidines; Pyrazoles; Receptors, N-Methyl-D-Aspartate | 2015 |
Impaired retinal vasodilator response to acetylcholine in a rat model of NMDA-induced retinal degeneration.
Topics: Acetylcholine; Adrenergic beta-3 Receptor Agonists; Animals; Dioxoles; Disease Models, Animal; Endothelial Cells; Male; N-Methylaspartate; Rats, Wistar; Receptors, Adrenergic, beta-3; Retinal Artery; Retinal Degeneration; Vasodilation | 2015 |
Ketogenic diet attenuates NMDA-induced damage to rat's retinal ganglion cells in an age-dependent manner.
Topics: Animals; Cell Count; D-Aspartic Acid; Diet Therapy; Diet, Ketogenic; Disease Models, Animal; Female; N-Methylaspartate; Neuroprotective Agents; Rats; Rats, Inbred BN; Retinal Degeneration; Retinal Ganglion Cells | 2015 |
FTY720 attenuates excitotoxicity and neuroinflammation.
Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents; Brain Diseases; Cell Death; Cells, Cultured; Cerebellum; Cerebral Cortex; Disease Models, Animal; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Fingolimod Hydrochloride; In Vitro Techniques; Kainic Acid; L-Lactate Dehydrogenase (Cytochrome); Male; N-Methylaspartate; Neurons; Organ Culture Techniques; Phosphorylation; Rats; Rats, Sprague-Dawley; Time Factors | 2015 |
High-mobility group Box-1 is involved in NMDA-induced retinal injury the in rat retina.
Topics: Animals; Apoptosis; Cell Death; Disease Models, Animal; HMGB1 Protein; Male; N-Methylaspartate; Oxidative Stress; Rats; Rats, Sprague-Dawley; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Retina; Retinal Diseases; Retinal Ganglion Cells | 2015 |
Autism-Associated Insertion Mutation (InsG) of Shank3 Exon 21 Causes Impaired Synaptic Transmission and Behavioral Deficits.
Topics: Animals; Disease Models, Animal; Excitatory Postsynaptic Potentials; Exons; Exploratory Behavior; Female; Grooming; Hippocampus; Locomotion; Male; Maze Learning; Mental Disorders; Mice; Mice, Transgenic; Microfilament Proteins; Mutagenesis, Insertional; Mutation; N-Methylaspartate; Nerve Tissue Proteins; Nesting Behavior; Sodium Channel Blockers; Synaptic Transmission; Tetrodotoxin | 2015 |
Antidepressant-like effect of quercetin in bulbectomized mice and involvement of the antioxidant defenses, and the glutamatergic and oxidonitrergic pathways.
Topics: Animals; Antidepressive Agents; Antioxidants; Arginine; Behavior, Animal; Disease Models, Animal; Drug Synergism; Fluoxetine; Hippocampus; Indazoles; Male; Methylene Blue; Mice; N-Methylaspartate; Olfactory Bulb; Oxidative Stress; Quercetin; Signal Transduction; Sildenafil Citrate | 2015 |
Phosphatase inhibition prevents the activity-dependent trafficking of GABAA receptors during status epilepticus in the young animal.
Topics: Animals; Animals, Newborn; Anticonvulsants; Cells, Cultured; Diazepam; Disease Models, Animal; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Hippocampus; Immunosuppressive Agents; In Vitro Techniques; N-Methylaspartate; Neurons; Okadaic Acid; Organ Culture Techniques; Phosphoric Monoester Hydrolases; Pilocarpine; Protein Transport; Rats; Rats, Sprague-Dawley; Receptors, GABA; Status Epilepticus; Tacrolimus | 2015 |
Adenosine A3 receptor activation is neuroprotective against retinal neurodegeneration.
Topics: Adenosine; Adenosine A3 Receptor Agonists; Adenosine A3 Receptor Antagonists; Animals; Animals, Newborn; Apoptosis; Cell Survival; Disease Models, Animal; Excitatory Amino Acid Agonists; Fluorescent Antibody Technique, Indirect; In Situ Nick-End Labeling; Intravitreal Injections; Male; N-Methylaspartate; Neuroprotection; Optic Nerve Injuries; Organ Culture Techniques; Rats; Rats, Wistar; Receptor, Adenosine A3; Retina; Retinal Degeneration; Retinal Neurons | 2015 |
Serotonergic interaction between medial prefrontal cortex and mesotelencephalic DA system underlies cognitive and affective deficits in hemiparkinsonian rats.
Topics: Adrenergic Agents; Animals; Cognition Disorders; Disease Models, Animal; Excitatory Amino Acid Agonists; Functional Laterality; Male; Maze Learning; Mood Disorders; Motor Activity; N-Methylaspartate; Oxidopamine; Parkinsonian Disorders; Prefrontal Cortex; Rats; Rats, Wistar; Sensory Gating; Telencephalon | 2015 |
Gene expression of NMDA and AMPA receptors in different facial motor neurons.
Topics: Animals; Disease Models, Animal; Facial Nerve; Gene Expression Regulation; Male; Motor Neurons; N-Methylaspartate; Peripheral Nerve Injuries; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Receptors, AMPA; Reverse Transcriptase Polymerase Chain Reaction; RNA | 2016 |
Leukotriene enhances NMDA-induced inward currents in dorsal horn neurons of the rat spinal cord after peripheral nerve injury.
Topics: Animals; Disease Models, Animal; Excitatory Postsynaptic Potentials; GTP-Binding Proteins; Ion Channel Gating; Leukotriene B4; Male; N-Methylaspartate; Peripheral Nerve Injuries; Posterior Horn Cells; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Leukotriene; RNA, Messenger; Synapses; Synaptic Transmission | 2015 |
The role of TRPA1 in muscle pain and mechanical hypersensitivity under inflammatory conditions in rats.
Topics: Adenosine Triphosphate; Animals; Disease Models, Animal; Excitatory Amino Acid Agonists; Freund's Adjuvant; Hyperalgesia; Male; Myalgia; Myositis; N-Methylaspartate; Oximes; Pain Threshold; Rats; Rats, Sprague-Dawley; Trigeminal Ganglion; TRPA1 Cation Channel; TRPC Cation Channels; Up-Regulation | 2015 |
β-Hydroxybutyrate attenuates NMDA-induced spasms in rats with evidence of neuronal stabilization on MR spectroscopy.
Topics: 3-Hydroxybutyric Acid; Animals; Anticonvulsants; Brain; Disease Models, Animal; Humans; Infant, Newborn; Magnetic Resonance Spectroscopy; N-Methylaspartate; Rats; Seizures; Spasms, Infantile; Treatment Outcome | 2015 |
Protective Effects of Everolimus against N-Methyl-D-aspartic Acid-Induced Retinal Damage in Rats.
Topics: Animals; Disease Models, Animal; Everolimus; Extracellular Signal-Regulated MAP Kinases; In Situ Nick-End Labeling; Inflammation; Intravitreal Injections; Leukocyte Common Antigens; Male; N-Methylaspartate; Neuroprotective Agents; Phosphorylation; Protein Kinase Inhibitors; Rats, Sprague-Dawley; Retina; Retinal Diseases; Retinal Ganglion Cells; Sirolimus; TOR Serine-Threonine Kinases | 2015 |
Development of a mouse model of infantile spasms induced by N-methyl-D-aspartate.
Topics: Adrenocorticotropic Hormone; Age Factors; Animals; Animals, Newborn; Anticonvulsants; Disease Models, Animal; Electroencephalography; Excitatory Amino Acid Agonists; Exploratory Behavior; Female; Humans; Infant; Learning Disabilities; Male; Maze Learning; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; N-Methylaspartate; Psychomotor Performance; Spasms, Infantile; Species Specificity; Video Recording | 2015 |
Role of the endocannabinoid 2-arachidonoylglycerol in aversive responses mediated by the dorsolateral periaqueductal grey.
Topics: Animals; Arachidonic Acids; Biphenyl Compounds; Cannabinoid Receptor Antagonists; Disease Models, Animal; Dose-Response Relationship, Drug; Endocannabinoids; Fluorescent Antibody Technique; Glycerides; Male; N-Methylaspartate; Panic Disorder; Periaqueductal Gray; Piperidines; Pyrazoles; Rats, Wistar; Receptor, Cannabinoid, CB1 | 2016 |
Allogeneic Transplantation of Müller-Derived Retinal Ganglion Cells Improves Retinal Function in a Feline Model of Ganglion Cell Depletion.
Topics: Animals; Cats; Cell Adhesion; Collagen; Disease Models, Animal; Electroretinography; Ependymoglial Cells; Humans; N-Methylaspartate; Neuroprotection; Primary Cell Culture; Retinal Degeneration; Retinal Ganglion Cells; Stem Cell Transplantation; Stem Cells; Tissue Scaffolds; Transplantation, Heterologous; Transplantation, Homologous; Vitrectomy; Vitreous Body | 2016 |
Antidepressant action of ketamine via mTOR is mediated by inhibition of nitrergic Rheb degradation.
Topics: Animals; Antidepressive Agents; Cells, Cultured; Cerebral Cortex; Cysteine; Depression; Disease Models, Animal; Embryo, Mammalian; Exploratory Behavior; Female; Gene Expression Regulation; HEK293 Cells; Humans; Ketamine; Male; Mice, Inbred C57BL; Mice, Knockout; Monomeric GTP-Binding Proteins; N-Methylaspartate; Neurons; Neuropeptides; Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Pregnancy; Proteolysis; Ras Homolog Enriched in Brain Protein; S-Nitrosothiols; Signal Transduction; Swimming; Time Factors; TOR Serine-Threonine Kinases | 2016 |
Enhanced long-term potentiation in mature rats in a model of epileptic spasms with betamethasone-priming and postnatal N-methyl-D-aspartate administration.
Topics: Age Factors; Animals; Animals, Newborn; Betamethasone; Disease Models, Animal; Epilepsy; Female; Long-Term Potentiation; Male; N-Methylaspartate; Organ Culture Techniques; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley | 2016 |
Pathway-Specific Remodeling of Thalamostriatal Synapses in Parkinsonian Mice.
Topics: Adrenergic Agents; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Corpus Striatum; Disease Models, Animal; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Exploratory Behavior; Functional Laterality; Homeodomain Proteins; Medial Forebrain Bundle; Mice; N-Methylaspartate; Neural Pathways; Oxidopamine; Parkinsonian Disorders; Synapses; Thalamus; Transcription Factors; Tyrosine 3-Monooxygenase; Vesicular Glutamate Transport Protein 2 | 2016 |
Mitochondrial dysfunction and lipid peroxidation in rat frontal cortex by chronic NMDA administration can be partially prevented by lithium treatment.
Topics: Aldehydes; Animals; Antidepressive Agents; Dinoprost; Disease Models, Animal; Excitatory Amino Acid Agonists; Frontal Lobe; Gene Expression Regulation; Lipid Peroxidation; Lithium; Male; Mitochondrial Diseases; Multienzyme Complexes; N-Methylaspartate; Rats; Rats, Inbred F344; Statistics, Nonparametric | 2016 |
Source memory in rats is impaired by an NMDA receptor antagonist but not by PSD95-nNOS protein-protein interaction inhibitors.
Topics: Aminosalicylic Acids; Animals; Benzylamines; Cells, Cultured; Chlorophenols; Cyclic GMP; Disease Models, Animal; Disks Large Homolog 4 Protein; Dizocilpine Maleate; Embryo, Mammalian; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Hippocampus; Intracellular Signaling Peptides and Proteins; Male; Maze Learning; Membrane Proteins; Memory Disorders; N-Methylaspartate; Neurons; Nitric Oxide Synthase Type I; Rats; Rats, Long-Evans; Triazoles | 2016 |
Protective action of nicotinic acid benzylamide in a variety of chemically-induced seizures in mice.
Topics: Animals; Anticonvulsants; Benzyl Compounds; Disease Models, Animal; Male; Memory Disorders; Memory, Long-Term; Mice; N-Methylaspartate; Niacin; Protective Agents; Seizures | 2016 |
Rat intra-hippocampal NMDA infusion induces cell-specific damage and changes in expression of NMDA and GABAA receptor subunits.
Topics: Animals; Disease Models, Animal; Functional Laterality; Hippocampus; Male; Maze Learning; N-Methylaspartate; Nerve Degeneration; Neurodegenerative Diseases; Neuroimmunomodulation; Neurons; Rats, Long-Evans; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate | 2016 |
Acute Hyperammonemia Induces NMDA-Mediated Hypophosphorylation of Intermediate Filaments Through PP1 and PP2B in Cerebral Cortex of Young Rats.
Topics: Acetates; Aging; Ammonium Chloride; Animals; Astrocytes; Calcineurin; Calcium; Calcium Signaling; Cerebral Cortex; Disease Models, Animal; Hippocampus; Hyperammonemia; Intermediate Filaments; N-Methylaspartate; Neurons; Phosphorylation; Protein Phosphatase 1; Rats, Wistar; Time Factors; Tissue Culture Techniques | 2016 |
Increased precipitation of spasms in an animal model of infantile spasms by prenatal stress exposure.
Topics: Adrenocorticotropic Hormone; Animals; Brain; Cold Temperature; Disease Models, Animal; Excitatory Amino Acid Agonists; Female; Hormones; Humans; Infant; Infant, Newborn; Male; N-Methylaspartate; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Receptors, Neurotransmitter; Spasms, Infantile; Stress, Psychological; Swimming | 2016 |
Phenylketonuria: Direct and indirect effects of phenylalanine.
Topics: Animals; Cells, Cultured; Cofilin 1; Dendrites; Disease Models, Animal; Embryo, Mammalian; Entorhinal Cortex; Excitatory Amino Acid Agonists; Gene Expression Regulation; Hippocampus; In Vitro Techniques; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microglia; Mutation; N-Methylaspartate; Neurons; Phagocytosis; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias; rac1 GTP-Binding Protein; Synapses | 2016 |
Activation of N-methyl-d-aspartate receptors reduces heart rate variability and facilitates atrial fibrillation in rats.
Topics: Action Potentials; Animals; Atrial Fibrillation; Connexins; Disease Models, Animal; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Fibrosis; Gap Junction alpha-5 Protein; Heart Conduction System; Heart Rate; Male; Matrix Metalloproteinase 9; N-Methylaspartate; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Time Factors | 2017 |
Metabotropic glutamate receptor 5 responses dictate differentiation of neural progenitors to NMDA-responsive cells in fragile X syndrome.
Topics: Animals; Cell Differentiation; Cerebral Cortex; Disease Models, Animal; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Fragile X Syndrome; Humans; Male; Methoxyhydroxyphenylglycol; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Neural Stem Cells; Pyridines; Receptor, Metabotropic Glutamate 5 | 2017 |
Diazoxide enhances excitotoxicity-induced neurogenesis and attenuates neurodegeneration in the rat non-neurogenic hippocampus.
Topics: Administration, Oral; Animals; Astrocytes; Diazoxide; Disease Models, Animal; Doublecortin Protein; Hippocampus; KATP Channels; Male; Microglia; N-Methylaspartate; Neurodegenerative Diseases; Neurogenesis; Neurons; Neuroprotective Agents; Rats, Wistar | 2016 |
Potentiation of synaptic transmission in Rat anterior cingulate cortex by chronic itch.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Behavior, Animal; Chronic Disease; Cyclopropanes; Disease Models, Animal; Excitatory Postsynaptic Potentials; Gyrus Cinguli; N-Methylaspartate; Neurons; Pruritus; Rats, Sprague-Dawley; Receptors, AMPA; Synaptic Transmission; Up-Regulation | 2016 |
Alpha7 nicotinic acetylcholine receptor agonists and PAMs as adjunctive treatment in schizophrenia. An experimental study.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Antidepressive Agents; Antipsychotic Agents; Benzamides; Bridged Bicyclo Compounds; Citalopram; Depression; Disease Models, Animal; Dopamine; Excitatory Amino Acid Agonists; Male; N-Methylaspartate; Nicotinic Agonists; Phenylurea Compounds; Prefrontal Cortex; Pyramidal Cells; Rats, Sprague-Dawley; Rats, Wistar; Risperidone; Schizophrenia; Schizophrenic Psychology; Selective Serotonin Reuptake Inhibitors | 2016 |
Synaptic plasticity and spatial working memory are impaired in the CD mouse model of Williams-Beuren syndrome.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Excitatory Postsynaptic Potentials; Gene Deletion; Hippocampus; Long-Term Potentiation; Memory, Short-Term; Mice, Inbred C57BL; N-Methylaspartate; Neuronal Plasticity; Neurons; Presynaptic Terminals; Williams Syndrome | 2016 |
Firing characteristics of deep dorsal horn neurons after acute spinal transection during administration of agonists for 5-HT1B/1D and NMDA receptors.
Topics: Action Potentials; Animals; Disease Models, Animal; Excitatory Amino Acid Agonists; Interneurons; Mice, Inbred BALB C; Mice, Inbred C57BL; Microelectrodes; N-Methylaspartate; Oxazolidinones; Posterior Horn Cells; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT1D; Receptors, N-Methyl-D-Aspartate; Sacrum; Serotonin 5-HT1 Receptor Agonists; Spinal Cord Injuries; Tissue Culture Techniques; Tryptamines | 2016 |
β-arrestin-2 regulates NMDA receptor function in spinal lamina II neurons and duration of persistent pain.
Topics: Analgesics, Opioid; Animals; beta-Arrestin 2; Chronic Pain; Disease Models, Animal; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Humans; Hyperalgesia; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Mice, Knockout; N-Methylaspartate; Neuralgia; Neurons; Peripheral Nerve Injuries; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, mu; Spinal Cord Dorsal Horn; Substantia Gelatinosa; Time Factors | 2016 |
Decreased levels of NMDA but not AMPA receptors in the lipid-raft fraction of 3xTg-AD model of Alzheimer's disease: Relation to Arc/Arg3.1 protein expression.
Topics: Alzheimer Disease; Animals; Cytoskeletal Proteins; Disease Models, Animal; Hippocampus; Male; Membrane Microdomains; Mice; Mice, Transgenic; N-Methylaspartate; Nerve Tissue Proteins; Neuronal Plasticity; Neurons; Post-Synaptic Density; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Synapses | 2016 |
Structure-activity relationship for the anticonvulsant effects of organic solvents.
Topics: Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Male; Mice; N-Methylaspartate; Pentylenetetrazole; Seizures; Solvents; Structure-Activity Relationship | 2016 |
Hypoxia-Inducible Factor-1α Mediates Increased Sympathoexcitation via Glutamatergic N-Methyl-d-Aspartate Receptors in the Paraventricular Nucleus of Rats With Chronic Heart Failure.
Topics: Animals; Cell Line; Chromatin Immunoprecipitation; Chronic Disease; Disease Models, Animal; Disease Progression; Excitatory Amino Acid Agonists; Heart Failure; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; In Vitro Techniques; Male; N-Methylaspartate; Neurons; Paraventricular Hypothalamic Nucleus; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Sympathetic Nervous System; Up-Regulation | 2016 |
Alteration of Neurotrophic Factors After Transplantation of Bone Marrow Derived Lin-ve Stem Cell in NMDA-Induced Mouse Model of Retinal Degeneration.
Topics: Animals; Bone Marrow Cells; Brain-Derived Neurotrophic Factor; Ciliary Neurotrophic Factor; Disease Models, Animal; Female; Glial Cell Line-Derived Neurotrophic Factor; Homeodomain Proteins; Male; Mice; Mice, Inbred C57BL; N-Methylaspartate; Nerve Growth Factors; Retina; Retinal Degeneration; Retinal Ganglion Cells; Stem Cell Transplantation; Stem Cells; Transcription Factor Brn-3B | 2017 |
Spinal D-Serine Increases PKC-Dependent GluN1 Phosphorylation Contributing to the Sigma-1 Receptor-Induced Development of Mechanical Allodynia in a Mouse Model of Neuropathic Pain.
Topics: Animals; D-Amino-Acid Oxidase; Disease Models, Animal; Enzyme Inhibitors; Ethylenediamines; Excitatory Amino Acid Agonists; Gene Expression Regulation; Hyperalgesia; Male; Mice; Mice, Inbred ICR; Morpholines; N-Methylaspartate; Nerve Tissue Proteins; Neuralgia; Phosphorylation; Physical Stimulation; Protein Kinase C; Receptors, N-Methyl-D-Aspartate; Receptors, sigma; Serine; Sigma-1 Receptor; Spinal Cord | 2017 |
TFP5, a Peptide Inhibitor of Aberrant and Hyperactive Cdk5/p25, Attenuates Pathological Phenotypes and Restores Synaptic Function in CK-p25Tg Mice.
Topics: Alzheimer Disease; Animals; Antipsychotic Agents; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Disease Models, Animal; Doxycycline; Excitatory Amino Acid Agonists; Exploratory Behavior; Female; Hippocampus; Hyperkinesis; Long-Term Potentiation; Male; Maze Learning; Mice; Mice, Transgenic; Motor Activity; N-Methylaspartate; Peptides; Phosphotransferases; tau Proteins | 2017 |
Electrophysiological alterations in diaphragm muscle caused by abdominal ischemia-reperfusion.
Topics: 4-Aminopyridine; Action Potentials; Analysis of Variance; Animals; Biophysics; Diaphragm; Disease Models, Animal; Electric Stimulation; Excitatory Amino Acid Agonists; Ischemia; Male; Muscle Contraction; N-Methylaspartate; Potassium Channel Blockers; Rats; Rats, Wistar; Reperfusion Injury; Ryanodine; Time Factors | 2017 |
Ghrelin fibers from lateral hypothalamus project to nucleus tractus solitaries and are involved in gastric motility regulation in cisplatin-treated rats.
Topics: Animals; Antibodies; Antineoplastic Agents; Cisplatin; Disease Models, Animal; Eating; Gastrointestinal Motility; Ghrelin; Hypothalamic Area, Lateral; Kaolin; Male; N-Methylaspartate; Neural Pathways; Neurotransmitter Agents; Random Allocation; Rats, Wistar; Receptors, Ghrelin; Solitary Nucleus | 2017 |
The Relationship Between the Renin-Angiotensin-Aldosterone System and NMDA Receptor-Mediated Signal and the Prevention of Retinal Ganglion Cell Death.
Topics: Aldosterone; Animals; Apoptosis; Cell Count; Disease Models, Animal; Excitatory Amino Acid Agonists; Intravitreal Injections; Male; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Renin-Angiotensin System; Retinal Diseases; Retinal Ganglion Cells; Vitreous Body | 2017 |
Modulating the Balance of Synaptic and Extrasynaptic NMDA Receptors Shows Positive Effects against Amyloid-β-Induced Neurotoxicity.
Topics: Amyloid beta-Peptides; Animals; Antimetabolites; Cycloserine; Disease Models, Animal; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Hippocampus; Locomotion; Male; Maze Learning; N-Methylaspartate; Nesting Behavior; Neurotoxicity Syndromes; Peptide Fragments; Piperidines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Recognition, Psychology; Signal Transduction; Synapses | 2017 |
Trigeminal brainstem modulation of persistent orbicularis oculi muscle activity in a rat model of dry eye.
Topics: Animals; Blinking; Brain Stem; Disease Models, Animal; Dry Eye Syndromes; Male; N-Methylaspartate; Neurons; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Saline Solution, Hypertonic; Synaptic Transmission; Trigeminal Nerve | 2017 |
Characterization of osteopontin expression and function after status epilepticus.
Topics: Animals; CD11b Antigen; Cell Degranulation; Cells, Cultured; Disease Models, Animal; Electroshock; Embryo, Mammalian; Excitatory Amino Acid Agonists; Flurothyl; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Hyaluronan Receptors; Mice; Mice, Knockout; N-Methylaspartate; Neurons; Nitric Oxide Synthase Type II; Osteopontin; Pilocarpine; Prosencephalon; RNA, Messenger; Status Epilepticus | 2008 |
Alpha2 adrenergic modulation of NMDA receptor function as a major mechanism of RGC protection in experimental glaucoma and retinal excitotoxicity.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Calcium; Calcium Signaling; Disease Models, Animal; Excitatory Amino Acid Agonists; Glaucoma; Male; N-Methylaspartate; Neuroprotective Agents; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Quinoxalines; Rabbits; Rats; Rats, Inbred BN; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Receptors, N-Methyl-D-Aspartate; Retina; Retinal Ganglion Cells; Rolipram | 2008 |
Two different molecular mechanisms underlying progesterone neuroprotection against ischemic brain damage.
Topics: Animals; Behavior, Animal; Calcium; Cell Death; Disease Models, Animal; Hippocampus; Hormone Antagonists; Infarction, Middle Cerebral Artery; Male; Maze Learning; Memory; Mifepristone; Mitogen-Activated Protein Kinase 3; N-Methylaspartate; Neurofilament Proteins; Neuroprotective Agents; Progesterone; Protein Transport; Rats; Rats, Sprague-Dawley; Signal Transduction; Space Perception; Time Factors | 2008 |
[+]-Huperzine A treatment protects against N-methyl-D-aspartate-induced seizure/status epilepticus in rats.
Topics: Acetylcholinesterase; Alkaloids; Animals; Body Temperature; Disease Models, Animal; Electroencephalography; Heart Rate; Male; Motor Activity; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Seizures; Sesquiterpenes; Status Epilepticus | 2008 |
Fos expression following activation of the ventral pallidum in normal rats and in a model of Parkinson's Disease: implications for limbic system and basal ganglia interactions.
Topics: Animals; Basal Ganglia; Bicuculline; Brain; Cell Proliferation; Disease Models, Animal; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; GABA Antagonists; Globus Pallidus; Immunohistochemistry; Limbic System; Male; Microinjections; N-Methylaspartate; Neurons; Oncogene Proteins v-fos; Oxidopamine; Parkinson Disease, Secondary; Rats; Rats, Sprague-Dawley; Sympatholytics | 2008 |
Interplay between glutamate and serotonin within the dorsal periaqueductal gray modulates anxiety-related behavior of rats exposed to the elevated plus-maze.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Anxiety; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Glutamic Acid; Male; Maze Learning; N-Methylaspartate; Periaqueductal Gray; Piperazines; Rats; Rats, Wistar; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists | 2008 |
Increased NR2A expression and prolonged decay of NMDA-induced calcium transient in cerebellum of TgDyrk1A mice, a mouse model of Down syndrome.
Topics: Animals; Blotting, Western; Calcium; Cells, Cultured; Cerebellum; Disease Models, Animal; Down Syndrome; Dyrk Kinases; Gene Expression Profiling; Immunohistochemistry; In Vitro Techniques; Male; Mice; Mice, Transgenic; N-Methylaspartate; Neurons; Oligonucleotide Array Sequence Analysis; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Receptors, N-Methyl-D-Aspartate; Synaptosomes; Up-Regulation | 2008 |
Aluminum modulates effects of beta amyloid(1-42) on neuronal calcium homeostasis and mitochondria functioning and is altered in a triple transgenic mouse model of Alzheimer's disease.
Topics: Aluminum; Alzheimer Disease; Amyloid beta-Peptides; Animals; Calcium Signaling; Disease Models, Animal; Homeostasis; Humans; In Vitro Techniques; Male; Membrane Fluidity; Mice; Mice, Transgenic; Mitochondria; Multiprotein Complexes; N-Methylaspartate; Neurons; Oxygen Consumption; Peptide Fragments; Rats; Rats, Wistar | 2008 |
Exposure to cyclic intermittent hypoxia increases expression of functional NMDA receptors in the rat carotid body.
Topics: Adaptation, Physiological; Animals; Blotting, Western; Carotid Body; Carotid Sinus; Disease Models, Animal; Disks Large Homolog 4 Protein; Endothelin-1; Excitatory Amino Acid Antagonists; Glutamic Acid; Hypoxia; Immunohistochemistry; Intracellular Signaling Peptides and Proteins; Male; Membrane Proteins; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reverse Transcriptase Polymerase Chain Reaction; Tyrosine 3-Monooxygenase; Up-Regulation | 2009 |
Essential role for zinc-triggered p75NTR activation in preconditioning neuroprotection.
Topics: Animals; Apoptosis; Calcium; Cell Culture Techniques; Cerebral Cortex; Cerebral Infarction; Chelating Agents; Disease Models, Animal; Edetic Acid; Embryo, Mammalian; Enzyme Activation; Excitatory Amino Acid Agonists; Infarction, Middle Cerebral Artery; Ischemic Preconditioning; Laser-Doppler Flowmetry; Male; Mice; Mice, Transgenic; N-Methylaspartate; Neurons; Poly(ADP-ribose) Polymerases; Rats; Rats, Sprague-Dawley; Receptor, Nerve Growth Factor; Time Factors; Zinc | 2008 |
Ischemic tolerance following low dose NMDA involves modulation of cellular stress proteins.
Topics: Animals; Brain; Calpain; Cytoprotection; Disease Models, Animal; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Hypoxia-Ischemia, Brain; Infarction, Middle Cerebral Artery; Ischemic Preconditioning; Male; Membrane Proteins; Molecular Chaperones; N-Methylaspartate; Neuroprotective Agents; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Stress, Physiological | 2009 |
Behavioural effects of a selective NMDA NR1A/2B receptor antagonist in rats with unilateral 6-OHDA+parafascicular lesions.
Topics: Administration, Oral; Adrenergic Agents; Animals; Antiparkinson Agents; Behavior, Animal; Disease Models, Animal; Dopamine; Excitatory Amino Acid Antagonists; Female; Immunohistochemistry; Intralaminar Thalamic Nuclei; Levodopa; Medial Forebrain Bundle; N-Methylaspartate; Neurons; Oxidopamine; Parkinson Disease, Secondary; Postural Balance; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Rotation; Tyrosine 3-Monooxygenase | 2009 |
Rescue of neurons from ischemic injury by peroxisome proliferator-activated receptor-gamma requires a novel essential cofactor LMO4.
Topics: Adaptor Proteins, Signal Transducing; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cell Death; Cell Hypoxia; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; Electrophoretic Mobility Shift Assay; Embryo, Mammalian; Gene Expression Regulation; Glucose; Homeodomain Proteins; Hypoglycemic Agents; Immunoprecipitation; Infarction, Middle Cerebral Artery; Kainic Acid; LIM Domain Proteins; Mice; Mice, Knockout; N-Methylaspartate; Neurons; Oxygen; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; PPAR gamma; Rosiglitazone; Signal Transduction; Superoxide Dismutase; Thiazolidinediones; Trans-Activators; Transcription Factors | 2008 |
Chronic intermittent hypoxia impairs heart rate responses to AMPA and NMDA and induces loss of glutamate receptor neurons in nucleus ambiguous of F344 rats.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Baroreflex; Blood Pressure; Brain Stem; Disease Models, Animal; Down-Regulation; Excitatory Amino Acid Agonists; Heart; Heart Rate; Hypoxia; Microinjections; Motor Neurons; N-Methylaspartate; Nerve Degeneration; Rats; Rats, Inbred F344; Receptors, AMPA; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate | 2009 |
NMDA- and beta-amyloid1-42-induced neurotoxicity is attenuated in serine racemase knock-out mice.
Topics: Amyloid beta-Peptides; Animals; Brain; Chromatography, High Pressure Liquid; Disease Models, Animal; Humans; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Neurotoxicity Syndromes; Neurotoxins; Peptide Fragments; Racemases and Epimerases; Serine | 2008 |
Paradoxical facilitation of pentylenetetrazole-induced convulsion susceptibility in mice lacking neuronal nitric oxide synthase.
Topics: Animals; Convulsants; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Gene Expression Regulation; Imidazoles; Indazoles; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Neuroprotective Agents; Nitric Oxide; Nitric Oxide Synthase Type I; Pentylenetetrazole; Quinoxalines; Seizures | 2009 |
Edaravone, a free radical scavenger, protects against retinal damage in vitro and in vivo.
Topics: Animals; Antipyrine; Cell Line; Cell Survival; Culture Media; Disease Models, Animal; Dose-Response Relationship, Drug; Edaravone; Free Radical Scavengers; Free Radicals; Green Fluorescent Proteins; Male; Mice; Mice, Transgenic; N-Methylaspartate; Oxidative Stress; Rats; Retinal Diseases; Retinal Ganglion Cells; Thy-1 Antigens | 2009 |
Differential susceptibility to excitotoxic stress in YAC128 mouse models of Huntington disease between initiation and progression of disease.
Topics: Animals; Brain; Brain Ischemia; Cells, Cultured; Dendritic Spines; Disease Models, Animal; Disease Progression; Genetic Predisposition to Disease; Huntington Disease; Mice; Mice, Transgenic; N-Methylaspartate; Nerve Degeneration; Neurotoxins; Organ Culture Techniques; Phenotype; Quinolinic Acid; Stress, Physiological; Synaptic Membranes; Synaptic Potentials; Synaptic Transmission | 2009 |
Excitotoxicity-induced endocytosis confers drug targeting in cerebral ischemia.
Topics: Alanine; Animals; Animals, Newborn; Brain Ischemia; Cells, Cultured; Cerebral Cortex; Dextrans; Disease Models, Animal; Dynamin I; Endocytosis; Excitatory Amino Acid Agonists; Fluorescein-5-isothiocyanate; Gene Products, tat; Green Fluorescent Proteins; Horseradish Peroxidase; Injections, Intraventricular; Lysine; Male; Mutation; N-Methylaspartate; Neurons; Rats; Rats, Sprague-Dawley; Transfection; Vesicular Transport Proteins | 2009 |
Pretreatment with lovastatin prevents N-methyl-D-aspartate-induced neurodegeneration in the magnocellular nucleus basalis and behavioral dysfunction.
Topics: Analysis of Variance; Animals; Avoidance Learning; Basal Nucleus of Meynert; Behavioral Symptoms; Choline O-Acetyltransferase; Chromones; Disease Models, Animal; Drug Administration Schedule; Drug Interactions; Enzyme Inhibitors; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Male; Maze Learning; Mice; Mice, Inbred C57BL; Morpholines; N-Methylaspartate; Neurodegenerative Diseases; Reaction Time | 2009 |
Unconjugated TAT carrier peptide protects against excitotoxicity.
Topics: Age Factors; Animals; Animals, Newborn; Brain Ischemia; Cell Death; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Kainic Acid; L-Lactate Dehydrogenase; N-Methylaspartate; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; tat Gene Products, Human Immunodeficiency Virus; Time Factors | 2009 |
PGF(2alpha) FP receptor contributes to brain damage following transient focal brain ischemia.
Topics: Analysis of Variance; Animals; Antihypertensive Agents; Brain Infarction; Brain Injuries; Brain Ischemia; Disease Models, Animal; Excitatory Amino Acid Agonists; Latanoprost; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Nervous System Diseases; Prostaglandins F, Synthetic; Receptors, Prostaglandin; Receptors, Prostaglandin E | 2009 |
Protease-activated receptor 1-dependent neuronal damage involves NMDA receptor function.
Topics: Analysis of Variance; Animals; Brain Injuries; Cells, Cultured; Corpus Striatum; Disease Models, Animal; Dizocilpine Maleate; Embryo, Mammalian; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Guanidines; Injections, Intraventricular; Ischemic Attack, Transient; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Neurons; Oligopeptides; Pregnancy; Rats; Receptor, PAR-1; Receptors, N-Methyl-D-Aspartate | 2009 |
Calpain-mediated N-cadherin proteolytic processing in brain injury.
Topics: Animals; Animals, Newborn; beta Catenin; Biotinylation; Brain Injuries; Cadherins; Calcium; Calpain; Cells, Cultured; Disease Models, Animal; Dizocilpine Maleate; Embryo, Mammalian; Endocytosis; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Gene Expression Regulation; Green Fluorescent Proteins; In Vitro Techniques; Ionomycin; Ionophores; Mice; Models, Biological; Mutation; N-Methylaspartate; Neurons; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Signal Transduction; Subcellular Fractions; Transfection; Wnt Proteins | 2009 |
Neurophysiological and neurochemical animal models of schizophrenia: focus on glutamate.
Topics: Acoustic Stimulation; Amphetamine; Animals; Brain; Disease Models, Animal; Dopamine; Electroencephalography; Evoked Potentials, Auditory; Glutamic Acid; Haplorhini; Humans; Microdialysis; N-Methylaspartate; Rats; Schizophrenia; Schizophrenic Psychology; Synaptic Transmission | 2009 |
Neuroprotective effects of vinpocetine and its major metabolite cis-apovincaminic acid on NMDA-induced neurotoxicity in a rat entorhinal cortex lesion model.
Topics: Animals; Disease Models, Animal; Entorhinal Cortex; Male; Maze Learning; N-Methylaspartate; Neuroprotective Agents; Rats; Rats, Wistar; Vinca Alkaloids | 2009 |
Age and albumin D site-binding protein control tissue plasminogen activator levels: neurotoxic impact.
Topics: Aged; Aged, 80 and over; Aging; Animals; Brain; Brain Ischemia; Cell Death; Disease Models, Animal; DNA-Binding Proteins; Female; Gene Knockdown Techniques; Humans; Magnetic Resonance Imaging; Mice; Mice, Inbred C57BL; Middle Aged; N-Methylaspartate; Neurons; Reverse Transcriptase Polymerase Chain Reaction; Tissue Plasminogen Activator; Transcription Factors | 2009 |
GIF-0173 protects against cerebral infarction through DP1 receptor activation.
Topics: Animals; Brain Infarction; Calcium; Cell Death; Cells, Cultured; Cerebral Cortex; Cerebrovascular Circulation; Dantrolene; Disease Models, Animal; Dose-Response Relationship, Drug; Glutamic Acid; Hydantoins; Infarction, Middle Cerebral Artery; Intracellular Fluid; Lactones; Laser-Doppler Flowmetry; Male; N-Methylaspartate; Neurons; Neuroprotective Agents; Platelet Aggregation Inhibitors; Prostaglandin D2; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Immunologic; Receptors, Prostaglandin; Sesquiterpenes; Severity of Illness Index; Tetrazolium Salts | 2009 |
GOSPEL: a neuroprotective protein that binds to GAPDH upon S-nitrosylation.
Topics: 2',5'-Oligoadenylate Synthetase; Animals; Binding, Competitive; Brain; Carrier Proteins; Cells, Cultured; Disease Models, Animal; Embryo, Mammalian; Excitatory Amino Acid Agonists; Glyceraldehyde-3-Phosphate Dehydrogenases; Green Fluorescent Proteins; Humans; Mice; Mice, Knockout; Molecular Weight; MPTP Poisoning; Mutation; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Neuroprotective Agents; Nitric Oxide Synthase Type I; Nuclear Proteins; Protein Binding; Protein Transport; RNA, Messenger; RNA, Small Interfering; S-Nitrosoglutathione; Transfection; Two-Hybrid System Techniques; Ubiquitin-Protein Ligases | 2009 |
Excitotoxic motoneuron degeneration induced by glutamate receptor agonists and mitochondrial toxins in organotypic cultures of chick embryo spinal cord.
Topics: Animals; Calcium Signaling; Chick Embryo; Disease Models, Animal; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Glutamic Acid; Kainic Acid; Malonates; Mitochondria; Motor Neuron Disease; Motor Neurons; N-Methylaspartate; Nerve Degeneration; Neuroprotective Agents; Neurotoxins; Nitro Compounds; Organ Culture Techniques; Propionates; Riluzole; Spinal Cord | 2009 |
Combination treatment with ethyl pyruvate and aspirin enhances neuroprotection in the postischemic brain.
Topics: Animals; Aspirin; Astringents; Astrocytes; Brain Infarction; Cells, Cultured; Cerebral Cortex; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Embryo, Mammalian; Excitatory Amino Acid Agonists; Gene Expression Regulation; Glucose; Hypoxia; Infarction, Middle Cerebral Artery; Male; N-Methylaspartate; Neurons; Neuroprotective Agents; NF-kappa B; Polysaccharides; Pyruvates; Rats; Rats, Sprague-Dawley; Rotarod Performance Test; Severity of Illness Index; Time Factors; Zinc Sulfate | 2010 |
Disruption of mesolimbic regulation of prefrontal cholinergic transmission in an animal model of schizophrenia and normalization by chronic clozapine treatment.
Topics: Acetylcholine; Aging; Amphetamine; Animals; Animals, Newborn; Clozapine; Disease Models, Animal; Hippocampus; Ibotenic Acid; Male; Microinjections; N-Methylaspartate; Neural Pathways; Nucleus Accumbens; Prefrontal Cortex; Rats; Rats, Wistar; Schizophrenia; Time Factors | 2009 |
Potentiation of excitatory serotonergic responses by MK-801 in the medial prefrontal cortex.
Topics: Animals; Disease Models, Animal; Dizocilpine Maleate; Electrophysiology; Excitatory Amino Acid Antagonists; Iontophoresis; Male; N-Methylaspartate; Prefrontal Cortex; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2C; Schizophrenia; Serotonin; Synaptic Transmission | 2009 |
The analgesic action of topical diclofenac may be mediated through peripheral NMDA receptor antagonism.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anesthetics, Local; Animals; Biophysics; Dinoprostone; Disease Models, Animal; Dose-Response Relationship, Drug; Electric Stimulation; Evoked Potentials; Excitatory Amino Acid Antagonists; Injections, Intramuscular; Isoquinolines; Male; Musculoskeletal Diseases; N-Methylaspartate; Pain; Physical Stimulation; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Serotonin; Time Factors | 2009 |
Vigabatrin but not valproate prevents development of age-specific flexion seizures induced by N-methyl-D-aspartate (NMDA) in immature rats.
Topics: Age Factors; Animals; Animals, Newborn; Anticonvulsants; Behavior, Animal; Disease Models, Animal; Epilepsy, Tonic-Clonic; Humans; Infant; N-Methylaspartate; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Seizures; Spasms, Infantile; Valproic Acid; Vigabatrin | 2010 |
Lomerizine, a Ca2+ channel blocker, protects against neuronal degeneration within the visual center of the brain after retinal damage in mice.
Topics: Animals; Calcium Channel Blockers; Disease Models, Animal; Geniculate Bodies; Male; Mice; Mice, Inbred C57BL; N-Methylaspartate; Nerve Degeneration; Phosphopyruvate Hydratase; Piperazines; Proto-Oncogene Proteins c-fos; Retinal Diseases; Retinal Ganglion Cells; Statistics, Nonparametric; Superior Colliculi; Time Factors; Visual Pathways | 2010 |
Remodeling of striatal NMDA receptors by chronic A(2A) receptor blockade in Huntington's disease mice.
Topics: Adenosine A2 Receptor Antagonists; Animals; Brain-Derived Neurotrophic Factor; Central Nervous System Agents; Corpus Striatum; Disease Models, Animal; Female; Huntington Disease; In Vitro Techniques; Male; Mice; Mice, Transgenic; N-Methylaspartate; Neuronal Plasticity; Neurotoxins; Pyrimidines; Receptor, Adenosine A2A; Receptor, trkB; Receptors, N-Methyl-D-Aspartate; Triazoles | 2010 |
An endocannabinoid tone limits excitotoxicity in vitro and in a model of multiple sclerosis.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Arachidonic Acids; Astrocytes; Cannabinoid Receptor Modulators; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; Endocannabinoids; Excitatory Amino Acid Transporter 2; Female; Furans; Mice; Mice, Inbred Strains; Mice, Knockout; Multiple Sclerosis; N-Methylaspartate; Neurons; Neuroprotective Agents; Neurotoxins; Polyunsaturated Alkamides; PPAR gamma; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2 | 2010 |
Loss of photic entrainment at low illuminances in rats with acute photoreceptor degeneration.
Topics: Animals; Circadian Rhythm; Disease Models, Animal; Gene Expression Regulation; Light; Light Signal Transduction; Lighting; Male; N-Methylaspartate; Opsins; Photic Stimulation; Photoreceptor Cells, Vertebrate; Rats; Rats, Long-Evans; Retinal Degeneration; Rhodopsin; Rod Opsins | 2009 |
Dysmyelinated axons in shiverer mice are highly vulnerable to alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor-mediated toxicity.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Biomarkers; Brain; Disease Models, Animal; Excitatory Amino Acid Agonists; Female; Hereditary Central Nervous System Demyelinating Diseases; Luminescent Proteins; Mice; Mice, Inbred C57BL; Mice, Neurologic Mutants; Movement Disorders; Myelin Basic Protein; N-Methylaspartate; Nerve Degeneration; Nerve Fibers, Myelinated; Neurotoxins; Receptors, AMPA | 2010 |
S 24795 limits beta-amyloid-alpha7 nicotinic receptor interaction and reduces Alzheimer's disease-like pathologies.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Alzheimer Disease; Amyloid beta-Peptides; Animals; Calcium; Cholinergic Agonists; Disease Models, Animal; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Frontal Lobe; Hippocampus; Immunoprecipitation; Injections, Intraventricular; Male; Mice; Mice, Inbred C57BL; N-Methylaspartate; Organ Culture Techniques; Peptide Fragments; Phosphorylation; Pyridinium Compounds; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Nicotinic; Synaptosomes | 2010 |
Rapid and noninvasive imaging of retinal ganglion cells in live mouse models of glaucoma.
Topics: Animals; Cell Count; Cell Death; Disease Models, Animal; Fluorescence; Fundus Oculi; Glaucoma; Green Fluorescent Proteins; Intraocular Pressure; Kainic Acid; Mice; Molecular Imaging; N-Methylaspartate; Neurotoxins; Retinal Ganglion Cells; Thy-1 Antigens; Time Factors | 2010 |
Anticonvulsant effects of Searsia dentata (Anacardiaceae) leaf extract in rats.
Topics: Anacardiaceae; Animals; Anticonvulsants; Bicuculline; Disease Models, Animal; Epilepsy; Kainic Acid; Male; N-Methylaspartate; Pentylenetetrazole; Plant Extracts; Plant Leaves; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Seizures | 2010 |
Progressive changes in synaptic inputs to motoneurons in adult sacral spinal cord of a mouse model of amyotrophic lateral sclerosis.
Topics: Action Potentials; Age Factors; Amyotrophic Lateral Sclerosis; Animals; Biophysics; Chi-Square Distribution; Disease Models, Animal; Disease Progression; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Humans; Interneurons; Mice; Mice, Transgenic; Motor Neurons; Mutation; N-Methylaspartate; Patch-Clamp Techniques; Psychomotor Performance; Quinoxalines; Reaction Time; Reflex; Spinal Cord; Superoxide Dismutase; Superoxide Dismutase-1; Synapses | 2009 |
N-methyl-D-aspartate preconditioning improves short-term motor deficits outcome after mild traumatic brain injury in mice.
Topics: Animals; Brain Injuries; Cell Count; Cerebellum; Cerebral Cortex; Disease Models, Animal; DNA Fragmentation; Dyskinesias; Male; Mice; Motor Activity; N-Methylaspartate; Neuroprotective Agents; Postural Balance; Severity of Illness Index; Time Factors; Treatment Outcome | 2010 |
Altered open field behavior in rats induced by acute administration of 3-nitropropionic acid: possible glutamatergic and dopaminergic involvement.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Dizocilpine Maleate; Dopamine Agents; Dopamine D2 Receptor Antagonists; Excitatory Amino Acid Agents; Huntington Disease; Male; Motor Activity; N-Methylaspartate; Nitro Compounds; Propionates; Quinpirole; Rats; Rats, Wistar; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Glutamate; Sulpiride | 2009 |
Early functional outcomes and histological analysis after spinal cord compression injury in rats.
Topics: Animals; Autonomic Nervous System; Catheterization; Cyclohexenes; Disease Models, Animal; Excitatory Amino Acid Antagonists; Male; Motor Activity; N-Methylaspartate; Piperidines; Rats; Rats, Wistar; Reflex; Sensory Receptor Cells; Spinal Cord; Spinal Cord Compression; Spinal Cord Injuries; Urination | 2010 |
Caffeinol at the receptor level: anti-ischemic effect of N-methyl-D-aspartate receptor blockade is potentiated by caffeine.
Topics: Animals; Brain Ischemia; Caffeine; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Combinations; Drug Synergism; Ethanol; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Guanidines; Male; N-Methylaspartate; Nerve Degeneration; Neuroprotective Agents; Neurotoxins; Phosphodiesterase Inhibitors; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Time Factors; Treatment Outcome | 2010 |
The role of the mGluR allosteric modulation in the NMDA-hypofunction model of schizophrenia.
Topics: Allosteric Regulation; Animals; Disease Models, Animal; Humans; Ketamine; N-Methylaspartate; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Schizophrenia | 2009 |
Alterations of white matter tracts following neurotoxic hippocampal lesions in macaque monkeys: a diffusion tensor imaging study.
Topics: Animals; Anisotropy; Brain Mapping; Diffusion Magnetic Resonance Imaging; Disease Models, Animal; Excitatory Amino Acid Agonists; Hippocampus; Macaca mulatta; Male; N-Methylaspartate; Nerve Fibers, Myelinated; Neurotoxicity Syndromes | 2010 |
Minocycline treatment reduces white matter damage after excitotoxic striatal injury.
Topics: Animals; Anti-Bacterial Agents; Antibodies, Monoclonal; Brain; Corpus Striatum; Disease Models, Animal; Macrophage Activation; Male; Microglia; Microinjections; Minocycline; Myelin Basic Protein; N-Methylaspartate; Oligodendroglia; Rats; Rats, Wistar; Time Factors | 2010 |
Delta oscillation and short-term plasticity in the rat medial prefrontal cortex: modelling NMDA hypofunction of schizophrenia.
Topics: Animals; Biphenyl Compounds; Delta Rhythm; Disease Models, Animal; Dizocilpine Maleate; Electric Stimulation; Electroencephalography; Excitatory Postsynaptic Potentials; Hippocampus; Lidocaine; Male; N-Methylaspartate; Neuronal Plasticity; Prefrontal Cortex; Quinazolines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Sulfonamides; Synaptic Transmission; Time Factors | 2011 |
N-methyl-D-aspartate, hyperpolarization-activated cation current (Ih) and gamma-aminobutyric acid conductances govern the risk of epileptogenesis following febrile seizures in rat hippocampus.
Topics: Animals; Animals, Newborn; Bicuculline; Biophysics; Cyclic Nucleotide-Gated Cation Channels; Disease Models, Animal; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; gamma-Aminobutyric Acid; Hippocampus; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Hyperthermia, Induced; In Vitro Techniques; Male; N-Methylaspartate; Patch-Clamp Techniques; Potassium Channels; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Seizures, Febrile; Statistics, Nonparametric; Synapses | 2010 |
Reboxetine enhances the olanzapine-induced antipsychotic-like effect, cortical dopamine outflow and NMDA receptor-mediated transmission.
Topics: Animals; Antipsychotic Agents; Avoidance Learning; Behavior, Animal; Benzodiazepines; Cerebral Cortex; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Drug Synergism; Excitatory Amino Acid Agonists; Freezing Reaction, Cataleptic; In Vitro Techniques; Male; Membrane Potentials; Microdialysis; Morpholines; N-Methylaspartate; Olanzapine; Rats; Rats, Sprague-Dawley; Rats, Wistar; Reboxetine; Receptors, N-Methyl-D-Aspartate | 2010 |
The DREAM protein negatively regulates the NMDA receptor through interaction with the NR1 subunit.
Topics: Analysis of Variance; Animals; Biotinylation; Brain Edema; Brain Infarction; Brain Ischemia; Cell Count; Cells, Cultured; CHO Cells; Cricetinae; Cricetulus; Disease Models, Animal; Dose-Response Relationship, Drug; Embryo, Mammalian; Excitatory Amino Acid Agonists; Gene Expression Regulation; Glucose; Green Fluorescent Proteins; Hippocampus; Humans; Hypoxia; Immunoprecipitation; Kv Channel-Interacting Proteins; L-Lactate Dehydrogenase; Membrane Potentials; Mice; Mice, Inbred BALB C; Mutation; N-Methylaspartate; Neurons; Neuroprotective Agents; Oocytes; Patch-Clamp Techniques; Peptides; Protein Binding; Protein Transport; Rats; Receptors, N-Methyl-D-Aspartate; Repressor Proteins; RNA, Small Interfering; Time Factors; Transfection; Xenopus | 2010 |
Model of cryptogenic infantile spasms after prenatal corticosteroid priming.
Topics: Adrenocorticotropic Hormone; Animals; Animals, Newborn; Betamethasone; Brain Stem; Disease Models, Animal; Electroencephalography; Hippocampus; Humans; Hypothalamus; Infant; N-Methylaspartate; Rats; Spasms, Infantile | 2010 |
Anticonvulsant activity of berberine, an isoquinoline alkaloid in mice.
Topics: Animals; Anticonvulsants; Berberine; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Electroshock; Kainic Acid; Male; Mice; N-Methylaspartate; Pentylenetetrazole; Rotarod Performance Test; Seizures | 2010 |
Characterization of neurotoxic effects of NMDA and the novel neuroprotection by phytopolyphenols in mice.
Topics: Analysis of Variance; Animals; Biphenyl Compounds; Ca(2+) Mg(2+)-ATPase; Calcium; Disease Models, Animal; Drug Interactions; Excitatory Amino Acid Agonists; Flavonoids; Lignans; Linear Models; Male; Membrane Potential, Mitochondrial; Mice; Motor Activity; N-Methylaspartate; Neurons; Neuroprotective Agents; Neurotoxicity Syndromes; Phenols; Phytotherapy; Polyphenols; Psychomotor Performance; Reactive Oxygen Species; Rotarod Performance Test; Silver Staining; Sodium-Potassium-Exchanging ATPase; Synaptosomes | 2010 |
The antinociceptive effects of AR-A014418, a selective inhibitor of glycogen synthase kinase-3 beta, in mice.
Topics: Abdominal Pain; Aggression; Analgesics; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Azides; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Formaldehyde; Glutamic Acid; Glycogen Synthase Kinase 3; Inflammation; Male; Mice; N-Methylaspartate; Pain Measurement; Sugar Acids; Thiazoles; Urea; Xylose | 2011 |
NMDA-mediated Ca(2+) influx drives aberrant ryanodine receptor activation in dendrites of young Alzheimer's disease mice.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Cadmium Chloride; Caffeine; Central Nervous System Stimulants; Disease Models, Animal; Drug Interactions; Electric Stimulation; Endoplasmic Reticulum; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Gene Expression Regulation; Heparin; Humans; In Vitro Techniques; Membrane Potentials; Mice; Mice, Inbred C57BL; Microscopy, Confocal; Mutation; N-Methylaspartate; Patch-Clamp Techniques; Prefrontal Cortex; Presenilin-1; Pyramidal Cells; Ryanodine Receptor Calcium Release Channel; tau Proteins; Transglutaminases | 2010 |
The KATP channel activator diazoxide ameliorates amyloid-β and tau pathologies and improves memory in the 3xTgAD mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Analysis of Variance; Animals; Antipsychotic Agents; Calcium; Cells, Cultured; Cerebral Cortex; Diazoxide; Disease Models, Animal; Dose-Response Relationship, Drug; Embryo, Mammalian; Excitatory Amino Acid Agonists; Gene Expression Regulation; Humans; KATP Channels; Membrane Potential, Mitochondrial; Membrane Potentials; Memory Disorders; Mice; Mice, Transgenic; Mutation; N-Methylaspartate; Oxygen; Patch-Clamp Techniques; Potassium Channels, Inwardly Rectifying; Presenilin-1; Rats; RNA, Messenger; tau Proteins; Tauopathies | 2010 |
The puzzle box as a simple and efficient behavioral test for exploring impairments of general cognition and executive functions in mouse models of schizophrenia.
Topics: Animals; Behavior, Animal; Cognition Disorders; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Executive Function; Gene Expression Regulation; Hippocampus; Kaplan-Meier Estimate; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Prefrontal Cortex; Problem Solving; Reaction Time; Receptors, AMPA; Receptors, Dopamine D2; Schizophrenia | 2011 |
NMDA-mediated regulation of DSCAM dendritic local translation is lost in a mouse model of Down's syndrome.
Topics: Animals; Animals, Newborn; Cell Adhesion Molecules; Cells, Cultured; Dendrites; Disease Models, Animal; Down Syndrome; Female; Hippocampus; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; N-Methylaspartate; Neuronal Plasticity; Protein Biosynthesis; Xenopus laevis | 2010 |
Lesions of the medial prefrontal cortex enhance social modulation of avoidance.
Topics: Animals; Anxiety; Avoidance Learning; Behavior, Animal; Disease Models, Animal; Exploratory Behavior; Inhibition, Psychological; Male; Maze Learning; N-Methylaspartate; Prefrontal Cortex; Rats; Rats, Wistar; Reaction Time; Social Behavior; Time Factors | 2011 |
Zinc pre-treatment enhances NMDAR-mediated excitotoxicity in cultured cortical neurons from SOD1(G93A) mouse, a model of amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Cell Culture Techniques; Cell Death; Cerebral Cortex; Disease Models, Animal; Excitatory Amino Acid Agonists; Female; Humans; Male; Mice; Mice, Transgenic; Motor Neurons; N-Methylaspartate; Neurons; Neurotoxins; Neurotransmitter Agents; Reactive Oxygen Species; Receptors, N-Methyl-D-Aspartate; Superoxide Dismutase; Zinc | 2011 |
SUN N8075, a novel radical scavenger, protects against retinal cell death in mice.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Aniline Compounds; Animals; Cell Death; Deoxyguanosine; Disease Models, Animal; Dizocilpine Maleate; In Situ Nick-End Labeling; Mice; N-Methylaspartate; Neurons; Neuroprotective Agents; Ocular Hypertension; Piperazines; Retina; Retinal Diseases; Time Factors | 2011 |
Involvement of the thalamic parafascicular nucleus in mesial temporal lobe epilepsy.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Biophysical Phenomena; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalography; Epilepsy, Temporal Lobe; Evoked Potentials, Somatosensory; Excitatory Amino Acid Antagonists; Functional Laterality; GABA-A Receptor Agonists; Hippocampus; Intralaminar Thalamic Nuclei; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Muscimol; N-Methylaspartate; Neurons; Statistics, Nonparametric; Time Factors; Wakefulness | 2010 |
Spinal transient receptor potential ankyrin 1 channel contributes to central pain hypersensitivity in various pathophysiological conditions in the rat.
Topics: Acetanilides; Analysis of Variance; Animals; Ankyrins; Calcium Channels; Capsaicin; Cholecystokinin; Cinnamomum zeylanicum; Disease Models, Animal; Dose-Response Relationship, Drug; Formaldehyde; Hyperalgesia; Male; N-Methylaspartate; Pain Measurement; Peripheral Nervous System Diseases; Purines; Rats; Rats, Wistar; Sleep Deprivation; Spinal Cord; TRPA1 Cation Channel; TRPC Cation Channels | 2011 |
Myelin-associated glycoprotein protects neurons from excitotoxicity.
Topics: Animals; Antibodies; Cells, Cultured; Disease Models, Animal; Disease Susceptibility; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Hippocampus; Humans; In Vitro Techniques; Integrin beta Chains; Kainic Acid; Magnetic Resonance Imaging; Mice; Mice, Inbred C57BL; Mice, Knockout; Myelin Proteins; Myelin-Associated Glycoprotein; N-Methylaspartate; Neurons; Peptide Fragments; Phosphoinositide Phospholipase C; Receptors, Cell Surface; Seizures; Signal Transduction; Tubulin | 2011 |
Anticonvulsant profile of the alkaloids (+)-erythravine and (+)-11-α-hydroxy-erythravine isolated from the flowers of Erythrina mulungu Mart ex Benth (Leguminosae-Papilionaceae).
Topics: Animals; Anticonvulsants; Bicuculline; Chi-Square Distribution; Disease Models, Animal; Dose-Response Relationship, Drug; Fabaceae; Flowers; Heterocyclic Compounds, 4 or More Rings; Injections, Intraventricular; Kainic Acid; Male; N-Methylaspartate; Pentylenetetrazole; Phytotherapy; Plant Extracts; Rats; Rats, Wistar; Reaction Time; Seizures | 2011 |
Increased hippocampal glycine uptake and cognitive dysfunction after peripheral nerve injury.
Topics: Animals; Cognition Disorders; Disease Models, Animal; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Exploratory Behavior; Fluoroacetates; Glycine; Herb-Drug Interactions; Hippocampus; Hyperalgesia; In Vitro Techniques; Male; Membrane Potentials; Mice; Mice, Inbred Strains; Motor Activity; N-Methylaspartate; Neurons; Pain Measurement; Pain Threshold; Patch-Clamp Techniques; Recognition, Psychology; Sarcosine; Sciatic Neuropathy | 2011 |
Cortical and hippocampal EEG effects of neurotransmitter agonists in spontaneously hypertensive vs. kainate-treated rats.
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Baclofen; Clonidine; Disease Models, Animal; Electrodes, Implanted; Electroencephalography; Epilepsy; Excitatory Amino Acid Agonists; Frontal Lobe; Hippocampus; Hypertension; Kainic Acid; Muscimol; N-Methylaspartate; Neurotransmitter Agents; Rats; Rats, Inbred SHR; Receptors, GABA-B; Receptors, N-Methyl-D-Aspartate | 2011 |
The optic nerve head is the site of axonal transport disruption, axonal cytoskeleton damage and putative axonal regeneration failure in a rat model of glaucoma.
Topics: Amyloid beta-Protein Precursor; Animals; Axonal Transport; Cholera Toxin; Cytoskeleton; Disease Models, Animal; Excitatory Amino Acid Agonists; Gene Expression Regulation; Glaucoma; HSP27 Heat-Shock Proteins; Myelin Basic Protein; N-Methylaspartate; Nerve Regeneration; Nerve Tissue Proteins; Optic Disk; Organic Chemicals; Rats; Retinal Ganglion Cells; RNA, Messenger; Time Factors | 2011 |
Dual vulnerability of tau to calpains and caspase-3 proteolysis under neurotoxic and neurodegenerative conditions.
Topics: Analysis of Variance; Animals; Animals, Newborn; Brain; Brain Injuries; Calpain; Caspase 3; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; Gene Expression Regulation; Male; Molecular Weight; N-Methylaspartate; Nerve Degeneration; Neurons; Neurotoxicity Syndromes; Neurotoxins; Peptide Hydrolases; Protein Isoforms; Rats; tau Proteins | 2011 |
Forebrain striatal-specific expression of mutant huntingtin protein in vivo induces cell-autonomous age-dependent alterations in sensitivity to excitotoxicity and mitochondrial function.
Topics: Aging; Animals; Corpus Striatum; Disease Models, Animal; Electron Transport Chain Complex Proteins; Electron Transport Complex II; Electrophysiology; Huntingtin Protein; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mitochondria; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Nuclear Proteins; Prosencephalon; Quinolinic Acid | 2011 |
Cerebroside-A provides potent neuroprotection after cerebral ischaemia through reducing glutamate release and Ca²⁺ influx of NMDA receptors.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Analysis of Variance; Animals; Brain Ischemia; Calcium; Cerebral Infarction; Cerebrosides; Charybdotoxin; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glucose; Glutamic Acid; Hippocampus; Hypoxia; In Vitro Techniques; Infarction, Middle Cerebral Artery; Long-Term Potentiation; Male; Mice; Mice, Inbred C57BL; N-Methylaspartate; Neuroprotective Agents; Neurotoxins; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Tetrazolium Salts; Valine | 2012 |
A novel free radical scavenger rescues retinal cells in vivo.
Topics: Animals; Apoptosis; Benzopyrans; Blotting, Western; Cell Count; Disease Models, Animal; Electrophoresis, Polyacrylamide Gel; Female; Free Radical Scavengers; In Situ Nick-End Labeling; Injections, Intraperitoneal; Intravitreal Injections; Light; Male; Malondialdehyde; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; N-Methylaspartate; Photoreceptor Cells, Vertebrate; Radiation Injuries, Experimental; Reactive Oxygen Species; Retina; Retinal Degeneration; Retinal Ganglion Cells; Superoxides | 2011 |
Neurobiological activity of Parawixin 10, a novel anticonvulsant compound isolated from Parawixia bistriata spider venom (Araneidae: Araneae).
Topics: Analysis of Variance; Animals; Anticonvulsants; Ataxia; Cerebral Cortex; Chromatography, High Pressure Liquid; Disease Models, Animal; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Kainic Acid; Male; Motor Activity; N-Methylaspartate; Rats; Rats, Wistar; Reaction Time; Seizures; Spider Venoms; Synaptosomes; Tritium | 2011 |
Involvement of nitric oxide-cGMP pathway in the antidepressant-like effect of ascorbic acid in the tail suspension test.
Topics: Animals; Antidepressive Agents; Arginine; Ascorbic Acid; Cyclic GMP; Depression; Disease Models, Animal; Dizocilpine Maleate; Enzyme Inhibitors; Exploratory Behavior; Female; Hindlimb Suspension; Indazoles; Mice; N-Methylaspartate; Nitric Oxide; Oxadiazoles; Piperazines; Purines; Quinoxalines; Signal Transduction; Sildenafil Citrate; Sulfones | 2011 |
Antagonism of stimulation-produced analgesia by naloxone and N-methyl-D-aspartate: role of opioid and N-methyl-D-aspartate receptors.
Topics: Analgesia; Analgesics, Opioid; Animals; Disease Models, Animal; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Hot Temperature; Ketamine; Male; Morphine; N-Methylaspartate; Naloxone; Narcotic Antagonists; Neuralgia; Periaqueductal Gray; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid; Sciatic Nerve | 2012 |
Effect of inner retinal dysfunction on slow double-stimulation multifocal electroretinogram.
Topics: Adaptation, Physiological; Adult; Animals; Case-Control Studies; Disease Models, Animal; Early Diagnosis; Electroretinography; Gerbillinae; Glaucoma, Open-Angle; Humans; Middle Aged; N-Methylaspartate; Photic Stimulation; Retina; Retinal Diseases; Tetrodotoxin; Visual Fields | 2011 |
Validation of the rat model of cryptogenic infantile spasms.
Topics: Adrenocorticotropic Hormone; Animals; Animals, Newborn; Betamethasone; Disease Models, Animal; Electroencephalography; Exploratory Behavior; Female; GABA Agents; Glucocorticoids; Humans; Infant, Newborn; Male; Maze Learning; Methylprednisolone; N-Methylaspartate; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Spasms, Infantile; Time Factors; Vigabatrin | 2011 |
Interleukin-10 overexpression does not synergize with the neuroprotective action of RGD-containing vectors after postnatal brain excitotoxicity but modulates the main inflammatory cell responses.
Topics: Analysis of Variance; Animals; Animals, Newborn; CD11b Antigen; Cell Death; Cytokines; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Female; Fluoresceins; Gene Expression Regulation; Genetic Vectors; Glial Fibrillary Acidic Protein; Histidine; Interleukin-10; Macrophages; Male; N-Methylaspartate; Neuroglia; Neuroprotective Agents; Neurotoxicity Syndromes; Neutrophils; Oligopeptides; Organic Chemicals; Peroxidase; Plant Lectins; Rats; Rats, Long-Evans; Transduction, Genetic; Vimentin | 2012 |
Interactions between nitrous oxide and tissue plasminogen activator in a rat model of thromboembolic stroke.
Topics: Animals; Binding Sites; Brain; Disease Models, Animal; Isoflurane; Male; N-Methylaspartate; Neuroprotective Agents; Nitrous Oxide; Rats; Rats, Sprague-Dawley; Stroke; Thromboembolism; Tissue Plasminogen Activator; Xenon | 2011 |
Gene transfer of neuronal nitric oxide synthase to the paraventricular nucleus reduces the enhanced glutamatergic tone in rats with chronic heart failure.
Topics: Adenoviridae; Analysis of Variance; Animals; Blotting, Western; Disease Models, Animal; Down-Regulation; Excitatory Amino Acid Agents; Fluorescent Antibody Technique; Heart Failure; Male; N-Methylaspartate; Nitric Oxide Synthase; Paraventricular Hypothalamic Nucleus; Random Allocation; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Transfection | 2011 |
Roles of p75(NTR), long-term depression, and cholinergic transmission in anxiety and acute stress coping.
Topics: Acetylcholine; Adaptation, Psychological; Analysis of Variance; Animals; Anxiety; Biophysics; Cholinergic Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Electric Stimulation; Exploratory Behavior; Hippocampus; In Vitro Techniques; Long-Term Synaptic Depression; Male; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Knockout; Microdialysis; Microinjections; N-Methylaspartate; Patch-Clamp Techniques; Proto-Oncogene Proteins c-fos; Receptors, Nerve Growth Factor; Stress, Psychological; Time Factors | 2012 |
Longitudinal and simultaneous imaging of retinal ganglion cells and inner retinal layers in a mouse model of glaucoma induced by N-methyl-D-aspartate.
Topics: Amacrine Cells; Animals; Disease Models, Animal; Disease Progression; Excitatory Amino Acid Agonists; Glaucoma; Green Fluorescent Proteins; Longitudinal Studies; Male; Mice; Mice, Transgenic; N-Methylaspartate; Ophthalmoscopy; Optic Disk; Reproducibility of Results; Retinal Ganglion Cells; Tomography, Optical Coherence | 2011 |
Excitotoxicity-induced endocytosis mediates neuroprotection by TAT-peptide-linked JNK inhibitor.
Topics: Analysis of Variance; Animals; Animals, Newborn; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; Endocytosis; Excitatory Amino Acid Agonists; Infarction, Middle Cerebral Artery; JNK Mitogen-Activated Protein Kinases; L-Lactate Dehydrogenase; N-Methylaspartate; Neurons; Neuroprotective Agents; Peptides; Phosphopyruvate Hydratase; Rats; Rats, Sprague-Dawley; Transfection | 2011 |
Selective inhibition of striatal fast-spiking interneurons causes dyskinesias.
Topics: Action Potentials; Adamantane; Analysis of Variance; Animals; Area Under Curve; Cholinergic Antagonists; Corpus Striatum; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Dyskinesias; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Female; Functional Laterality; Green Fluorescent Proteins; Interneurons; LIM-Homeodomain Proteins; Male; Mecamylamine; Mice; Mice, Transgenic; N-Methylaspartate; Nerve Tissue Proteins; Scopolamine; Transcription Factors | 2011 |
A critical window of CAG repeat-length correlates with phenotype severity in the R6/2 mouse model of Huntington's disease.
Topics: Analysis of Variance; Animals; Body Weight; Corpus Striatum; Disease Models, Animal; Disease Progression; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Exploratory Behavior; Genetic Predisposition to Disease; Genotype; Humans; Huntingtin Protein; Huntington Disease; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Mice; Mice, Inbred C57BL; Mice, Transgenic; Motor Activity; Muscle Strength; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Nuclear Proteins; Patch-Clamp Techniques; Phenotype; Rotarod Performance Test; Seizures; Trinucleotide Repeat Expansion | 2012 |
Exaggerated NMDA mediated LTD in a mouse model of Down syndrome and pharmacological rescuing by memantine.
Topics: Analysis of Variance; Animals; Disease Models, Animal; Down Syndrome; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Hippocampus; In Vitro Techniques; Long-Term Synaptic Depression; Memantine; Methoxyhydroxyphenylglycol; Mice; Mice, Mutant Strains; N-Methylaspartate; Time Factors; Trisomy | 2011 |
Excitotoxic lesions of the bed nucleus of the stria terminalis (BNST) attenuate the effects of repeated stress on weight gain: evidence for the recruitment of BNST activity by repeated, but not acute, stress.
Topics: Animals; Disease Models, Animal; Electroshock; Excitatory Amino Acid Agonists; Male; N-Methylaspartate; Phosphopyruvate Hydratase; Rats; Rats, Sprague-Dawley; Restraint, Physical; Septal Nuclei; Stress, Psychological; Time Factors; Weight Gain | 2012 |
Quantitative analysis of retinal ganglion cell survival with Rbpms immunolabeling in animal models of optic neuropathies.
Topics: Animals; Biomarkers; Cell Count; Cell Survival; Disease Models, Animal; Dizocilpine Maleate; Fluorescent Antibody Technique, Indirect; Glaucoma; Intraocular Pressure; Male; N-Methylaspartate; Nerve Crush; Optic Nerve Diseases; Optic Nerve Injuries; Rats; Rats, Inbred BN; Rats, Wistar; Retinal Ganglion Cells; RNA-Binding Proteins; Stilbamidines; Tonometry, Ocular; Tubulin | 2011 |
P2X7 receptor blockade prevents ATP excitotoxicity in neurons and reduces brain damage after ischemia.
Topics: Adenosine Triphosphate; Analysis of Variance; Animals; Brain Injuries; Calcium; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; Dose-Response Relationship, Drug; Embryo, Mammalian; Excitatory Amino Acid Agonists; Fluoresceins; Glucose; Hypoxia; In Vitro Techniques; Infarction, Middle Cerebral Artery; Membrane Potentials; N-Methylaspartate; Neurologic Examination; Neurons; Organic Chemicals; Patch-Clamp Techniques; Phosphopyruvate Hydratase; Purinergic P2X Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2X7; Rosaniline Dyes; Tetrazolium Salts | 2012 |
P38 MAPK is involved in enhanced NMDA receptor-dependent excitotoxicity in YAC transgenic mouse model of Huntington disease.
Topics: Analysis of Variance; Animals; Animals, Newborn; Apoptosis; Bacterial Proteins; Cerebral Cortex; Chromosomes, Artificial, Yeast; Coculture Techniques; Corpus Striatum; Disease Models, Animal; Disks Large Homolog 4 Protein; Embryo, Mammalian; Enzyme Inhibitors; Gene Expression Regulation; Guanylate Kinases; Humans; Huntingtin Protein; Huntington Disease; Immunoprecipitation; In Situ Nick-End Labeling; Luminescent Proteins; Membrane Proteins; Mice; Mice, Transgenic; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Nuclear Proteins; p38 Mitogen-Activated Protein Kinases; Peptides; Receptors, N-Methyl-D-Aspartate; Subcellular Fractions | 2012 |
Lesions of the thalamic reuniens cause impulsive but not compulsive responses.
Topics: Animals; Attention; Behavior, Animal; Choice Behavior; Compulsive Behavior; Disease Models, Animal; Habituation, Psychophysiologic; Impulsive Behavior; Inhibition, Psychological; Male; Midline Thalamic Nuclei; Motivation; Motor Activity; N-Methylaspartate; Neurotoxicity Syndromes; Rats; Rats, Long-Evans; Reaction Time; Reward; Time Factors | 2013 |
MicroRNA-132 dysregulation in schizophrenia has implications for both neurodevelopment and adult brain function.
Topics: Adult; Animals; Antipsychotic Agents; Bipolar Disorder; Brain; Cerebral Cortex; Databases, Genetic; Demography; Disease Models, Animal; DNA (Cytosine-5-)-Methyltransferases; DNA Methyltransferase 3A; GATA2 Transcription Factor; Gene Expression Regulation; HEK293 Cells; Humans; Mice; MicroRNAs; Muscle Proteins; N-Methylaspartate; Oligonucleotide Array Sequence Analysis; Open Reading Frames; Polymerase Chain Reaction; Rats; Receptors, N-Methyl-D-Aspartate; Reproducibility of Results; Schizophrenia; Signal Transduction | 2012 |
Reversal of metabolic and neurological symptoms of phenylketonuric mice treated with a PAH containing helper-dependent adenoviral vector.
Topics: Adenoviridae; Animals; Disease Models, Animal; Electrophysiology; Genetic Therapy; Genetic Vectors; Humans; Learning Disabilities; Mice; N-Methylaspartate; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias; Pigmentation; Tyrosine | 2012 |
Ex vivo and in vivo neuroprotection induced by argon when given after an excitotoxic or ischemic insult.
Topics: Animals; Argon; Brain; Brain Injuries; Brain Ischemia; Disease Models, Animal; Dose-Response Relationship, Drug; Glucose; Infarction, Middle Cerebral Artery; Male; Models, Statistical; N-Methylaspartate; Neurons; Neuroprotective Agents; Oxygen; Rats; Rats, Sprague-Dawley; Synapses | 2012 |
Endogenous ACh effects on NMDA-induced interictal-like discharges along the septotemporal hippocampal axis of adult rats and their modulation by an early life generalized seizure.
Topics: Acetylcholine; Analysis of Variance; Animals; Atropine; Cholinesterase Inhibitors; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Hippocampus; In Vitro Techniques; Male; Muscarinic Antagonists; N-Methylaspartate; Neurons; Pentylenetetrazole; Physostigmine; Rats; Rats, Sprague-Dawley; Seizures; Sex Factors; Valine | 2012 |
Cell swelling contributes to thickening of low-dose N-methyl-D-aspartate-induced retinal edema.
Topics: Animals; Apoptosis; Capillary Permeability; Contrast Media; Diffusion Magnetic Resonance Imaging; Disease Models, Animal; Excitatory Amino Acid Agonists; Gadolinium DTPA; In Situ Nick-End Labeling; Intravitreal Injections; Male; Mice; Mice, Inbred C57BL; N-Methylaspartate; Necrosis; Papilledema; Retina; Retinal Vessels | 2012 |
Effect of ageing on post-lesion oestradiol treatment on mouse cholinergic neurones in vivo.
Topics: Aging; Animals; Basal Nucleus of Meynert; Cell Death; Cholinergic Neurons; Disease Models, Animal; Estradiol; Estrous Cycle; Female; Male; Mice; Mice, Inbred C57BL; Microinjections; Molecular Imaging; N-Methylaspartate; Nerve Degeneration; Neural Pathways; Neuroprotective Agents; Somatosensory Cortex | 2012 |
The emergence of adolescent onset pain hypersensitivity following neonatal nerve injury.
Topics: Age Factors; Animals; Disease Models, Animal; Hyperalgesia; Male; N-Methylaspartate; Neuralgia; Nociception; Pain Threshold; Peripheral Nerve Injuries; Rats; Rats, Sprague-Dawley | 2012 |
Analgesic antidepressants promote the responsiveness of locus coeruleus neurons to noxious stimulation: implications for neuropathic pain.
Topics: Analgesics; Animals; Antidepressive Agents; Disease Models, Animal; Locus Coeruleus; Male; N-Methylaspartate; Neuralgia; Neurons; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Spinal Cord | 2012 |
PGC-1α negatively regulates extrasynaptic NMDAR activity and excitotoxicity.
Topics: Animals; Cell Death; Cells, Cultured; Cerebral Cortex; Corpus Striatum; Disease Models, Animal; Female; Gene Knockdown Techniques; Huntingtin Protein; Huntington Disease; Male; Membrane Potentials; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Nuclear Proteins; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; RNA-Binding Proteins; Transcription Factors | 2012 |
Lymphocyte cell kinase activation mediates neuroprotection during ischemic preconditioning.
Topics: Adaptor Proteins, Signal Transducing; Animals; Brain Ischemia; Cell Death; Cerebral Cortex; Disease Models, Animal; Gene Silencing; Glucose; Ischemic Preconditioning; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Mice; Mice, Knockout; N-Methylaspartate; Neurons; Neuroprotective Agents; Oxygen; Primary Cell Culture; Protein Kinase C-epsilon; RNA, Small Interfering | 2012 |
Involvement of mGlu5 and NMDA receptors in the antidepressant-like effect of acamprosate in the tail suspension test.
Topics: Acamprosate; Animals; Antidepressive Agents; Benzamides; Depression; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Hindlimb Suspension; Immobility Response, Tonic; Male; Mice; Mice, Inbred C57BL; Motor Activity; N-Methylaspartate; Pyrazoles; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Taurine | 2012 |
Guanosine produces an antidepressant-like effect through the modulation of NMDA receptors, nitric oxide-cGMP and PI3K/mTOR pathways.
Topics: Analysis of Variance; Animals; Antidepressive Agents; Arginine; Cyclic GMP; Depression; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Excitatory Amino Acid Agents; Exploratory Behavior; Female; Freezing Reaction, Cataleptic; Guanosine; Hindlimb Suspension; Immunosuppressive Agents; Male; Mice; N-Methylaspartate; Nitric Oxide; Phosphatidylinositol 3-Kinases; Receptors, N-Methyl-D-Aspartate; Serine; Signal Transduction; Sirolimus; Swimming; TOR Serine-Threonine Kinases | 2012 |
Fingolimod, a sphingosine-1 phosphate receptor modulator, increases BDNF levels and improves symptoms of a mouse model of Rett syndrome.
Topics: Animals; Astrocytes; Brain-Derived Neurotrophic Factor; Cell Death; Cells, Cultured; Disease Models, Animal; Excitatory Amino Acid Agonists; Female; Fingolimod Hydrochloride; Immunosuppressive Agents; MAP Kinase Signaling System; Methyl-CpG-Binding Protein 2; Mice; Motor Activity; N-Methylaspartate; Neurons; Organ Culture Techniques; Pregnancy; Propylene Glycols; Receptors, Lysosphingolipid; Rett Syndrome; Sphingosine | 2012 |
Involvement of Tyr1472 phosphorylation of NMDA receptor NR2B subunit in postherpetic neuralgia in model mice.
Topics: Animals; Calcitonin Gene-Related Peptide; Disease Models, Animal; Ganglia, Spinal; Gene Expression Regulation; Gene Knock-In Techniques; Glial Cell Line-Derived Neurotrophic Factor; Herpes Simplex; Herpesvirus 1, Human; Male; Mice; Mice, Inbred C57BL; Mutant Proteins; N-Methylaspartate; Neuralgia, Postherpetic; Neurites; Neurotoxins; Phosphorylation; Phosphotyrosine; Protein Subunits; Receptors, N-Methyl-D-Aspartate; Skin; Structure-Activity Relationship; Substance P | 2012 |
Protective effects of the β3-adrenoceptor agonist CL316243 against N-methyl-D-aspartate-induced retinal neurotoxicity.
Topics: Adrenergic beta-3 Receptor Agonists; Aminophenols; Animals; Dioxoles; Disease Models, Animal; Intravitreal Injections; Male; N-Methylaspartate; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Retinal Diseases; Retinal Ganglion Cells; Sulfonamides; Time Factors | 2012 |
Proteomic analysis of adrenocorticotropic hormone treatment of an infantile spasm model induced by N-methyl-D-aspartic acid and prenatal stress.
Topics: Adrenocorticotropic Hormone; Animals; Animals, Newborn; Blotting, Western; Disease Models, Animal; Electrophoresis, Gel, Two-Dimensional; Female; Humans; Infant, Newborn; N-Methylaspartate; Pregnancy; Proteome; Proteomics; Spasms, Infantile; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Stress, Physiological | 2012 |
Lasp1 is down-regulated in NMDA receptor antagonist-treated mice and implicated in human schizophrenia susceptibility.
Topics: Adaptor Proteins, Signal Transducing; Adult; Animals; Cytoskeletal Proteins; Disease Models, Animal; Dizocilpine Maleate; Down-Regulation; Female; Genetic Predisposition to Disease; Homeodomain Proteins; Humans; LIM Domain Proteins; Male; Mice; Mice, Inbred ICR; Middle Aged; N-Methylaspartate; Polymorphism, Single Nucleotide; Promoter Regions, Genetic; Random Allocation; Republic of Korea; Schizophrenia | 2013 |
Role of NMDA and opioid receptors in neuropathic pain induced by chronic constriction injury of sciatic nerve in rats.
Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Excitatory Amino Acid Agonists; Ketamine; Male; Morphine; N-Methylaspartate; Naloxone; Narcotic Antagonists; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid; Sciatic Neuropathy | 2012 |
N-methyl-D-aspartate (NMDA)-mediated excitotoxic damage: a mouse model of acute retinal ganglion cell damage.
Topics: Animals; Apoptosis; Disease Models, Animal; Excitatory Amino Acid Agonists; Eye; Eye Diseases; Mice; N-Methylaspartate; Neuroprotective Agents; Retinal Ganglion Cells | 2013 |
Diminished cortical inhibition in an aging mouse model of chronic tinnitus.
Topics: Acoustic Stimulation; Aging; Animals; Auditory Cortex; Auditory Threshold; Cerebral Cortex; Chronic Disease; Disease Models, Animal; Evoked Potentials, Auditory, Brain Stem; Flavoproteins; GABA Antagonists; gamma-Aminobutyric Acid; Hearing Loss, Noise-Induced; Male; Mice; Mice, Inbred CBA; N-Methylaspartate; Neural Inhibition; Pyridazines; Receptors, GABA-A; Reflex, Startle; Tinnitus | 2012 |
In vitro MS-based proteomic analysis and absolute quantification of neuronal-glial injury biomarkers in cell culture system.
Topics: Animals; Apoptosis; Biomarkers; Brain Injuries; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; Glial Fibrillary Acidic Protein; Marine Toxins; Mass Spectrometry; N-Methylaspartate; Necrosis; Neuroglia; Neurons; Oxocins; Protein Interaction Maps; Proteomics; Rats; Rats, Sprague-Dawley; Signal Transduction; Staurosporine; Ubiquitin Thiolesterase | 2012 |
Neuroprotective effects of olanzapine in N-methyl-D-aspartate-induced retinal injury.
Topics: Animals; Antipsychotic Agents; Benzodiazepines; Disease Models, Animal; Dose-Response Relationship, Drug; Ischemia; Male; Malondialdehyde; N-Methylaspartate; Neuroprotective Agents; Olanzapine; Rats; Rats, Wistar; Retina; Retinal Diseases; Retinal Ganglion Cells; Retinal Neurons | 2013 |
Protective effects of TGF-β inhibitors in a rat model of NMDA-induced retinal degeneration.
Topics: Animals; Benzamides; Capillaries; Dioxoles; Disease Models, Animal; Intravitreal Injections; Male; N-Methylaspartate; Pyrazoles; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Transforming Growth Factor beta; Retinal Diseases; Retinal Ganglion Cells; Retinal Vessels; Transforming Growth Factor beta | 2013 |
Deficits in morphofunctional maturation of hippocampal mossy fiber synapses in a mouse model of intellectual disability.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Outbred Strains; Disease Models, Animal; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; GluK2 Kainate Receptor; Intellectual Disability; Mice; Mice, Knockout; Mossy Fibers, Hippocampal; N-Methylaspartate; Presynaptic Terminals; Receptors, Kainic Acid; Synapses | 2012 |
Overexpression of the nuclear factor kappaB inhibitor A20 is neurotoxic after an excitotoxic injury to the immature rat brain.
Topics: Animals; Astrocytes; Brain Diseases; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; DNA-Binding Proteins; Excitatory Amino Acid Agonists; Immunohistochemistry; N-Methylaspartate; Neurons; NF-kappa B; Rats; Rats, Long-Evans; Rats, Transgenic; Tumor Necrosis Factor alpha-Induced Protein 3; Up-Regulation | 2013 |
Involvement of EphB1 receptors signalling in models of inflammatory and neuropathic pain.
Topics: Animals; Carrageenan; Cell Count; Disease Models, Animal; Electrophysiological Phenomena; Female; Formaldehyde; Gene Deletion; Gene Expression Regulation; Gene Knockout Techniques; Hyperalgesia; Inflammation; Locomotion; Male; Mice; N-Methylaspartate; Neuralgia; Posterior Horn Cells; Proto-Oncogene Proteins c-fos; Receptor, EphB1; Sciatic Nerve; Signal Transduction | 2013 |
BDNF prevents NMDA-induced toxicity in models of Huntington's disease: the effects are genotype specific and adenosine A2A receptor is involved.
Topics: Animals; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Female; Genotype; Huntington Disease; Male; Mice; Mice, Inbred C57BL; N-Methylaspartate; Patch-Clamp Techniques; Receptor, Adenosine A2A; Synaptic Transmission | 2013 |
Ergothioneine treatment protects neurons against N-methyl-D-aspartate excitotoxicity in an in vivo rat retinal model.
Topics: Amyloid beta-Protein Precursor; Animals; Antioxidants; Astrocytes; Cell Count; Cell Death; Disease Models, Animal; Down-Regulation; Ergothioneine; Female; Glial Fibrillary Acidic Protein; Glutamic Acid; N-Methylaspartate; Neurodegenerative Diseases; Neurons; Neuroprotective Agents; Neurotoxins; Oxidative Stress; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Retina; Retinal Ganglion Cells | 2002 |
Conantokin-L, a new NMDA receptor antagonist: determinants for anticonvulsant potency.
Topics: Amino Acid Sequence; Animals; Anticonvulsants; Cerebellar Cortex; Cloning, Molecular; Conotoxins; Disease Models, Animal; DNA, Complementary; Dose-Response Relationship, Drug; Epilepsy; Excitatory Amino Acid Antagonists; Female; Intercellular Signaling Peptides and Proteins; Male; Mice; Molecular Sequence Data; Mollusk Venoms; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Peptide Biosynthesis; Peptides; Receptors, N-Methyl-D-Aspartate; Sleep; Snails; Time Factors | 2002 |
Decrease of proinflammatory molecules correlates with neuroprotective effect of the fluorinated salicylate triflusal after postnatal excitotoxic damage.
Topics: Administration, Oral; Animals; Astrocytes; Cyclooxygenase 2; Disease Models, Animal; Inflammation Mediators; Interleukin-1; Isoenzymes; Microglia; Microinjections; N-Methylaspartate; Neurodegenerative Diseases; Neurons; Neuroprotective Agents; Neurotoxins; Neutrophil Infiltration; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Long-Evans; Salicylates; Somatosensory Cortex; Tumor Necrosis Factor-alpha | 2002 |
Striatal dopamine-NMDA receptor interactions in the modulation of glutamate release in the substantia nigra pars reticulata in vivo: opposite role for D1 and D2 receptors.
Topics: Animals; Corpus Striatum; Disease Models, Animal; Dopamine; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Glutamic Acid; Male; Microdialysis; N-Methylaspartate; Oxidopamine; Parkinsonian Disorders; Perfusion; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, N-Methyl-D-Aspartate; Substantia Nigra; Wakefulness | 2002 |
Increased severity of stroke in CB1 cannabinoid receptor knock-out mice.
Topics: Animals; Blood Flow Velocity; Blood Pressure; Brain; Cerebrovascular Circulation; Disease Models, Animal; Genotype; Heterozygote; Homozygote; Infarction, Middle Cerebral Artery; Male; Mice; Mice, Knockout; N-Methylaspartate; Neurons; Phenotype; Receptors, Cannabinoid; Receptors, Drug; Reperfusion; Stroke; Survival Rate | 2002 |
Identification of a monogenic locus (jams1) causing juvenile audiogenic seizures in mice.
Topics: Acoustic Stimulation; Age Factors; Animals; Antigens, CD; Antigens, Neoplasm; Antigens, Surface; Auditory Threshold; Avian Proteins; Basigin; Blood Proteins; Carrier Proteins; Disease Models, Animal; Epilepsy, Reflex; Evoked Potentials, Auditory, Brain Stem; Gene Expression Regulation, Developmental; Genes, Recessive; Genetic Linkage; Genetic Predisposition to Disease; Genotype; Hearing Tests; Membrane Glycoproteins; Membrane Proteins; Mice; Mice, Knockout; Mice, Mutant Strains; Microsatellite Repeats; N-Methylaspartate; Physical Chromosome Mapping; Picrotoxin; Vesicular Transport Proteins | 2002 |
Selective blockade of endothelin-B receptors exacerbates ischemic brain damage in the rat.
Topics: Animals; Antihypertensive Agents; Blood Flow Velocity; Brain Ischemia; Cerebrovascular Circulation; Disease Models, Animal; Endothelin Receptor Antagonists; Excitatory Amino Acid Agonists; Gene Expression; Infarction, Middle Cerebral Artery; Injections, Intraventricular; Male; N-Methylaspartate; Oligopeptides; Piperidines; Rats; Rats, Sprague-Dawley; Receptor, Endothelin B; Receptors, Endothelin; RNA, Messenger | 2002 |
Vampire bat salivary plasminogen activator (desmoteplase): a unique fibrinolytic enzyme that does not promote neurodegeneration.
Topics: Animals; Cell Count; Cell Survival; Corpus Striatum; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Fibrinolytic Agents; Hippocampus; Kainic Acid; Mice; Mice, Inbred C57BL; Mice, Knockout; Microglia; N-Methylaspartate; Neurodegenerative Diseases; Neurons; Plasminogen Activators; Tissue Plasminogen Activator | 2003 |
Neuroprotective effects of interleukin-6 on NMDA-induced rat retinal damage.
Topics: Animals; Blotting, Western; Contactins; Disease Models, Animal; In Situ Nick-End Labeling; Interleukin-6; Male; N-Methylaspartate; Neural Cell Adhesion Molecules; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Receptors, Interleukin-6; Retinal Diseases | 2003 |
Lead can inhibit NMDA-, K(+)-, QA/KA-induced increases in intracellular free Ca2+ in cultured rat hippocampal neurons.
Topics: Animals; Calcium; Cognition Disorders; Disease Models, Animal; Hippocampus; Kainic Acid; Lead; Learning Disabilities; Microscopy, Confocal; N-Methylaspartate; Neurons; Potassium; Quisqualic Acid; Rats; Rats, Wistar | 2002 |
Effects of inhaled toluene and 1,1,1-trichloroethane on seizures and death produced by N-methyl-D-aspartic acid in mice.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Tolerance; Excitatory Amino Acid Agonists; Illicit Drugs; Male; Mice; Mice, Inbred Strains; N-Methylaspartate; Seizures; Solvents; Time Factors; Toluene; Trichloroethanes | 2003 |
The novel neuroprotective action of sulfasalazine through blockade of NMDA receptors.
Topics: Animals; Antioxidants; Calcium; Cells, Cultured; Cerebral Cortex; Cyclooxygenase 2; Disease Models, Animal; Ischemia; Isoenzymes; Male; Mice; Mice, Inbred ICR; N-Methylaspartate; Neuroprotective Agents; NF-kappa B; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Retinal Diseases; Sulfasalazine | 2003 |
Neuroprotective effects of (+/-)-huprine Y on in vitro and in vivo models of excitoxicity damage.
Topics: Aminoquinolines; Animals; Binding, Competitive; Calcium; Cell Death; Cells, Cultured; Cerebellum; Corpus Striatum; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Gliosis; Glutamic Acid; Heat-Shock Proteins; Heterocyclic Compounds, 4 or More Rings; HSP27 Heat-Shock Proteins; Isoquinolines; Mice; Molecular Chaperones; Motor Activity; N-Methylaspartate; Neoplasm Proteins; Neurodegenerative Diseases; Neurons; Neuroprotective Agents; Neurotoxins; Nitro Compounds; Propionates; Rats | 2003 |
Creatine protects against the convulsive behavior and lactate production elicited by the intrastriatal injection of methylmalonate.
Topics: Animals; Behavior, Animal; Corpus Striatum; Creatine; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Lactic Acid; Male; Methylmalonic Acid; N-Methylaspartate; Phosphocreatine; Radiation-Protective Agents; Rats; Rats, Wistar; Seizures; Succinic Acid | 2003 |
The ability of new non-competitive glutamate receptor blockers to weaken motor disorders in animals.
Topics: Animals; Ataxia; Behavior, Animal; Catalepsy; Diamines; Disease Models, Animal; Dizocilpine Maleate; Dopamine Antagonists; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Haloperidol; Kainic Acid; Memantine; Mice; Mice, Inbred Strains; N-Methylaspartate; Quaternary Ammonium Compounds; Seizures; Structure-Activity Relationship; Time Factors | 2003 |
Basal ganglia efferents to the brainstem centers controlling postural muscle tone and locomotion: a new concept for understanding motor disorders in basal ganglia dysfunction.
Topics: Animals; Atropine; Basal Ganglia; Basal Ganglia Diseases; Bicuculline; Brain Stem; Cats; Choline O-Acetyltransferase; Disease Models, Animal; Efferent Pathways; Electric Stimulation; Electromyography; Evoked Potentials, Motor; Excitatory Amino Acid Agonists; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Kainic Acid; Locomotion; Muscarinic Antagonists; Muscimol; Muscle Tonus; N-Methylaspartate; Neural Inhibition; Picrotoxin; Stimulation, Chemical | 2003 |
Interleukin-6, beta-amyloid peptide and NMDA interactions in rat cortical neurons.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Calcium Signaling; Cell Death; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; Drug Interactions; Encephalitis; Excitatory Amino Acid Agonists; Fetus; Glutamic Acid; Interleukin-6; N-Methylaspartate; Nerve Degeneration; Neurons; Neurotoxins; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2003 |
Neuroprotective activity of antazoline against neuronal damage induced by limbic status epilepticus.
Topics: Animals; Animals, Newborn; Antazoline; Cell Count; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Electric Conductivity; Electroencephalography; Excitatory Amino Acid Agonists; Female; Hippocampus; Histamine H1 Antagonists; In Vitro Techniques; Male; Muscarinic Agonists; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Pilocarpine; Pregnancy; Rats; Rats, Sprague-Dawley; Status Epilepticus; Time Factors; Trauma, Nervous System | 2003 |
Redox regulation of neuronal migration in a Down Syndrome model.
Topics: Acetylcysteine; Animals; Chemotaxis; Disease Models, Animal; Dithiothreitol; Down Syndrome; Fetus; Glutamic Acid; Mice; N-Methylaspartate; Neurons; Oxidation-Reduction; Oxidative Stress; Receptors, N-Methyl-D-Aspartate; Trisomy | 2003 |
Glutamatergic activation of the amygdala differentially mimics the effects of audiogenic seizure kindling in two substrains of genetically epilepsy-prone rats.
Topics: Acoustic Stimulation; Amygdala; Animals; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy, Reflex; Female; Genetic Predisposition to Disease; Glutamic Acid; Kindling, Neurologic; Male; Microinjections; N-Methylaspartate; Rats; Rats, Inbred Strains; Rats, Sprague-Dawley; Seizures | 2003 |
Alteration of NMDA NR1 receptors within the paraventricular nucleus of hypothalamus in rats with heart failure.
Topics: Animals; Blood Pressure; Disease Models, Animal; Excitatory Amino Acid Antagonists; Glutamic Acid; Heart Failure; Heart Rate; Kidney; Male; Microdialysis; Microinjections; N-Methylaspartate; Paraventricular Hypothalamic Nucleus; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Sympathetic Nervous System | 2003 |
Ectopic expression of the catalytic subunit of telomerase protects against brain injury resulting from ischemia and NMDA-induced neurotoxicity.
Topics: Animals; Brain Injury, Chronic; Brain Ischemia; Calcium; Cells, Cultured; Coculture Techniques; Disease Models, Animal; DNA-Binding Proteins; Excitatory Amino Acid Agonists; Fluorescent Dyes; Gene Expression Regulation; Hypoxia-Ischemia, Brain; Membrane Potentials; Mice; Mice, Transgenic; Mitochondria; N-Methylaspartate; Neuroglia; Neurons; Neurotoxicity Syndromes; Neurotoxins; RNA, Messenger; Telomerase | 2004 |
Constitutive spinal cyclooxygenase-2 participates in the initiation of tissue injury-induced hyperalgesia.
Topics: Animals; Blotting, Western; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Disease Models, Animal; Hindlimb; Hyperalgesia; Immunohistochemistry; Injections, Spinal; Isoenzymes; Lumbosacral Region; Male; N-Methylaspartate; Neuroglia; Neurons; Physical Stimulation; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Spinal Cord; Substance P; Up-Regulation | 2004 |
A peptide derived from the C-terminal region of acetylcholinesterase modulates extracellular concentrations of acetylcholinesterase in the rat substantia nigra.
Topics: Acetylcholine; Acetylcholinesterase; Amino Acid Sequence; Amyloid beta-Protein Precursor; Animals; Calcium Signaling; Disease Models, Animal; Drug Interactions; Extracellular Fluid; Male; Molecular Sequence Data; N-Methylaspartate; Neurons; Parkinson Disease; Peptide Fragments; Protein Structure, Tertiary; Rats; Rats, Wistar; Substantia Nigra | 2004 |
Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration.
Topics: Activating Transcription Factor 1; Age Factors; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Antibodies, Monoclonal; Association Learning; Behavior, Animal; Blotting, Western; Brain; Calcium-Calmodulin-Dependent Protein Kinase Kinase; Carrier Proteins; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinases; Disease Models, Animal; DNA-Binding Proteins; Excitatory Amino Acid Agonists; Fear; gag Gene Products, Human Immunodeficiency Virus; Gene Expression Regulation; Gene Products, gag; Immunohistochemistry; In Vitro Techniques; Lamin Type B; Long-Term Potentiation; Membrane Potentials; Membrane Proteins; Memory Disorders; Mice; Mice, Knockout; Microtubule-Associated Proteins; N-Methylaspartate; Neurodegenerative Diseases; Neuronal Plasticity; Patch-Clamp Techniques; Precipitin Tests; Presenilin-1; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-fos; Reaction Time; Receptors, N-Methyl-D-Aspartate; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Transcription Factors; Viral Proteins | 2004 |
Effects of NMDA receptor-related agonists on learning and memory impairment in olfactory bulbectomized mice.
Topics: 2-Amino-5-phosphonovalerate; Animals; Avoidance Learning; Cycloserine; Disease Models, Animal; Dizocilpine Maleate; Drug Therapy, Combination; Injections, Intraventricular; Male; Memory Disorders; Mice; N-Methylaspartate; Olfactory Bulb; Piperidines; Receptors, N-Methyl-D-Aspartate; Spermidine; Time Factors | 2004 |
(-)-nicotine ameliorates corticosterone's potentiation of N-methyl-d-aspartate receptor-mediated cornu ammonis 1 toxicity.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Cell Survival; Corticosterone; Disease Models, Animal; Drug Interactions; Hippocampus; In Vitro Techniques; Male; Mifepristone; N-Methylaspartate; Neurons; Neuroprotective Agents; Neurotoxins; Nicotine; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Glucocorticoid; Receptors, N-Methyl-D-Aspartate; Receptors, Nicotinic | 2004 |
The effects of ketamine vary among inbred mouse strains and mimic schizophrenia for the P80, but not P20 or N40 auditory ERP components.
Topics: Animals; Disease Models, Animal; Evoked Potentials, Auditory; Humans; Ketamine; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Inbred Strains; N-Methylaspartate; Schizophrenia; Species Specificity | 2004 |
Involvement of RhoA and possible neuroprotective effect of fasudil, a Rho kinase inhibitor, in NMDA-induced neurotoxicity in the rat retina.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Count; Disease Models, Animal; Drug Interactions; Enzyme Inhibitors; Glutamic Acid; Intracellular Signaling Peptides and Proteins; Male; N-Methylaspartate; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Protein Serine-Threonine Kinases; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Retina; Retinal Degeneration; Retinal Ganglion Cells; rho-Associated Kinases; rhoA GTP-Binding Protein; RNA, Messenger; Thy-1 Antigens; Up-Regulation | 2004 |
Infarct reduction in rats following intraventricular administration of either tissue plasminogen activator (tPA) or its non-protease mutant S478A-tPA.
Topics: Animals; Brain; Brain Infarction; Brain Ischemia; Cells, Cultured; Coculture Techniques; Disease Models, Animal; Endopeptidases; Fetus; Infarction, Middle Cerebral Artery; Injections, Intraventricular; Male; Mice; Movement Disorders; Mutation; N-Methylaspartate; Protein Conformation; Rats; Rats, Sprague-Dawley; Tissue Plasminogen Activator; Treatment Outcome; Zinc | 2004 |
Altered sensorimotor development in a transgenic mouse model of amyotrophic lateral sclerosis.
Topics: Action Potentials; Amyotrophic Lateral Sclerosis; Animals; Animals, Newborn; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Functional Laterality; Hand Strength; In Vitro Techniques; Mice; Mice, Transgenic; Motor Activity; Motor Neurons; N-Methylaspartate; Psychomotor Performance; Serotonin; Spinal Nerve Roots; Superoxide Dismutase; Superoxide Dismutase-1 | 2004 |
Central amygdala ERK signaling pathway is critical to incubation of cocaine craving.
Topics: Amygdala; Anesthetics, Local; Animals; Behavior, Addictive; Behavior, Animal; Blotting, Western; Butadienes; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Cues; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Extinction, Psychological; Extracellular Signal-Regulated MAP Kinases; Food; Injections, Intravenous; Male; N-Methylaspartate; Nitriles; Phosphorylation; Rats; Rats, Long-Evans; Reinforcement, Psychology; Self Administration; Signal Transduction; Substance Withdrawal Syndrome; Time Factors | 2005 |
Divergent regulatory mechanisms governing BDNF mRNA expression in cerebral cortex and substantia nigra in response to striatal target ablation.
Topics: Animals; Brain-Derived Neurotrophic Factor; Cerebral Cortex; Corpus Striatum; Cyclopropanes; Denervation; Disease Models, Animal; Down-Regulation; Female; Glutamate Decarboxylase; Glycine; Huntington Disease; N-Methylaspartate; Neural Pathways; Neurons; Neurotoxins; Proto-Oncogene Proteins c-fos; Quinolinic Acid; Rats; Rats, Wistar; Receptor, trkB; RNA, Messenger; Substantia Nigra; Subthalamic Nucleus; Tyrosine 3-Monooxygenase | 2005 |
Increased susceptibility of glutathione peroxidase-1 transgenic mice to kainic acid-related seizure activity and hippocampal neuronal cell death.
Topics: Animals; Cell Death; Cells, Cultured; Disease Models, Animal; Epilepsy; Genetic Predisposition to Disease; Glutathione Disulfide; Glutathione Peroxidase; Hippocampus; Kainic Acid; Mice; Mice, Transgenic; N-Methylaspartate; Nerve Degeneration; Neurons; Neurotoxins; Organ Culture Techniques; Oxidative Stress; Receptors, N-Methyl-D-Aspartate; Up-Regulation | 2005 |
The influence of NMDA, a potent agonist of glutamate receptor, on behavioral activity of rats with experimental hyperammonemia evoked by liver failure.
Topics: Animals; Avoidance Learning; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Exploratory Behavior; Hyperammonemia; Liver Failure; Male; Maze Learning; Motor Activity; N-Methylaspartate; Rats; Rats, Wistar; Receptors, Glutamate; Seizures | 2005 |
Vascular endothelial growth factor counteracts NMDA-induced cell death of adult cholinergic neurons in rat basal nucleus of Meynert.
Topics: Age Factors; Alzheimer Disease; Animals; Axotomy; Basal Nucleus of Meynert; Blood Vessels; Cell Death; Choline O-Acetyltransferase; Cholinergic Fibers; Disease Models, Animal; Excitatory Amino Acid Agonists; Immunohistochemistry; Laminin; Male; N-Methylaspartate; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Organ Culture Techniques; Rats; Rats, Sprague-Dawley; Vascular Endothelial Growth Factor A | 2005 |
Prolonged NMDA-mediated responses, altered ifenprodil sensitivity, and epileptiform-like events in the malformed hippocampus of methylazoxymethanol exposed rats.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Epilepsy; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Hippocampus; In Vitro Techniques; Methylazoxymethanol Acetate; N-Methylaspartate; Patch-Clamp Techniques; Piperidines; Rats | 2005 |
Electrical and chemical long-term depression do not attenuate low-Mg2+-induced epileptiform activity in the entorhinal cortex.
Topics: Animals; Disease Models, Animal; Electric Stimulation; Electric Stimulation Therapy; Entorhinal Cortex; Epilepsy; Humans; In Vitro Techniques; Long-Term Potentiation; Long-Term Synaptic Depression; Magnesium Deficiency; Mice; N-Methylaspartate; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Seizures | 2005 |
Neuroprotective effects of cardiotrophin-like cytokine on retinal ganglion cells.
Topics: Animals; Cell Count; Cell Survival; Cytokines; Disease Models, Animal; Female; Follow-Up Studies; Injections; Macular Degeneration; N-Methylaspartate; Rats; Rats, Long-Evans; Retinal Ganglion Cells; Treatment Outcome; Vitreous Body | 2005 |
Neuroprotective effects of preconditioning ischaemia on ischaemic brain injury through inhibition of mixed-lineage kinase 3 via NMDA receptor-mediated Akt1 activation.
Topics: Animals; Blotting, Western; Brain; Brain Ischemia; Cell Death; Chromones; Dimethyl Sulfoxide; Disease Models, Animal; Drug Interactions; Enzyme Activation; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Free Radical Scavengers; Ischemic Preconditioning; Ketamine; Male; MAP Kinase Kinase Kinases; Mitogen-Activated Protein Kinase Kinase Kinase 11; Mitogen-Activated Protein Kinase Kinases; Models, Biological; Morpholines; N-Methylaspartate; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Receptors, N-Methyl-D-Aspartate; Reperfusion; Time Factors | 2005 |
The p53-independent nuclear translocation of cyclin G1 in degenerating neurons by ischemic and traumatic insults.
Topics: Animals; Brain Injuries; Brain Ischemia; Cell Death; Cells, Cultured; Cyclin G; Cyclin G1; Cyclins; Cycloheximide; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Embryo, Mammalian; Excitatory Amino Acid Agonists; Fluoresceins; Fluorescent Dyes; Gene Expression Regulation; Gerbillinae; Immunohistochemistry; In Situ Hybridization; In Situ Nick-End Labeling; Kainic Acid; Mice; Mice, Knockout; Microscopy, Immunoelectron; N-Methylaspartate; Nerve Degeneration; Neurons; Organic Chemicals; Phosphopyruvate Hydratase; Protein Synthesis Inhibitors; Rats; Rats, Wistar; Time Factors; Tumor Suppressor Protein p53 | 2005 |
Increased cold allodynia following intrathecal N-methyl-D-aspartate in rats with a mononeuropathy.
Topics: Animals; Cold Temperature; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Injections, Spinal; Male; N-Methylaspartate; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sciatic Neuropathy | 2005 |
Protein retention in the endoplasmic reticulum, blockade of programmed cell death and autophagy selectively occur in spinal cord motoneurons after glutamate receptor-mediated injury.
Topics: Amyotrophic Lateral Sclerosis; Animals; Anterior Horn Cells; Apoptosis; Autophagy; Axotomy; Chick Embryo; Disease Models, Animal; Endoplasmic Reticulum; Excitatory Amino Acid Agonists; Glutamic Acid; Inclusion Bodies; Microscopy, Electron, Transmission; Models, Neurological; N-Methylaspartate; Nerve Tissue Proteins; Neurofilament Proteins; Neurotoxins; Protein Biosynthesis; Receptors, Glutamate; Stress, Physiological | 2005 |
Differential inhibitory effects of honokiol and magnolol on excitatory amino acid-evoked cation signals and NMDA-induced seizures.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Biphenyl Compounds; Calcium; Cells, Cultured; Cerebellum; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Ion Channels; Lignans; Mice; N-Methylaspartate; Neurons; Platelet Aggregation Inhibitors; Potassium Chloride; Quinoxalines; Rats; Rats, Sprague-Dawley; Seizures; Sodium | 2005 |
Antiallodynic effects of NMDA glycine(B) antagonists in neuropathic pain: possible peripheral mechanisms.
Topics: Action Potentials; Animals; Constriction, Pathologic; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Kynurenic Acid; Ligation; Male; N-Methylaspartate; Neuralgia; Neurons, Afferent; Pain Measurement; Quinolones; Rats; Rats, Sprague-Dawley; Spinal Cord; Spinal Nerves; Time Factors | 2005 |
Sex differences in cell death.
Topics: Animals; Animals, Newborn; Cell Death; Disease Models, Animal; DNA-Binding Proteins; Drug Interactions; Female; Genotype; Glucose; High Mobility Group Proteins; Hippocampus; Hypoxia; Indazoles; Male; N-Methylaspartate; Neurons; Neuroprotective Agents; Nitric Oxide; Organ Culture Techniques; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sex Characteristics; SOXB1 Transcription Factors; Stroke; Superoxide Dismutase; Time Factors; Transcription Factors | 2005 |
Functional assessment of glutamate clearance mechanisms in a chronic rat glaucoma model using retinal ganglion cell calcium imaging.
Topics: Animals; Animals, Newborn; Aspartic Acid; Calcium; Cells, Cultured; Diagnostic Imaging; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Fura-2; Glaucoma; Glutamic Acid; In Vitro Techniques; Intraocular Pressure; Male; N-Methylaspartate; Optic Nerve; Rats; Rats, Long-Evans; Retina; Retinal Ganglion Cells; Time Factors | 2005 |
Regulation of NMDA receptor trafficking by amyloid-beta.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Calcineurin; Cell Membrane; Cerebral Cortex; CREB-Binding Protein; Disease Models, Animal; Electric Conductivity; Endocytosis; Enzyme Activation; Mice; N-Methylaspartate; Neurons; Nuclear Proteins; Peptide Fragments; Protein Transport; Protein Tyrosine Phosphatases; Protein Tyrosine Phosphatases, Non-Receptor; Receptors, N-Methyl-D-Aspartate; Receptors, Nicotinic; Signal Transduction; Synapses; Trans-Activators | 2005 |
Effects of inactivation of serotonergic neurons of the median raphe nucleus on learning and performance of contextual fear conditioning.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anxiety Disorders; Behavior, Animal; Conditioning, Psychological; Denervation; Disease Models, Animal; Excitatory Amino Acid Agonists; Fear; Learning; Male; N-Methylaspartate; Neural Pathways; Neurons; Neurotoxins; Pons; Raphe Nuclei; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1A; Reflex, Startle; Serotonin; Serotonin 5-HT1 Receptor Agonists; Serotonin Receptor Agonists | 2005 |
Evaluation of interaction between intrathecal adenosine and MK801 or NBQX in a rat formalin pain model.
Topics: Adenosine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Disease Models, Animal; Dizocilpine Maleate; Drug Synergism; Excitatory Amino Acid Antagonists; Formaldehyde; Injections, Spinal; Male; N-Methylaspartate; Pain; Quinoxalines; Rats; Rats, Sprague-Dawley | 2005 |
The brain-specific tissue-type plasminogen activator inhibitor, neuroserpin, protects neurons against excitotoxicity both in vitro and in vivo.
Topics: Animals; Apoptosis; Brain; Brain Ischemia; Calcium Signaling; Cells, Cultured; Cerebral Cortex; Corpus Striatum; Disease Models, Animal; Male; Mice; N-Methylaspartate; Neurons; Neuropeptides; Neuroprotective Agents; Neuroserpin; Neurotoxins; Receptors, N-Methyl-D-Aspartate; Serpins; Stroke | 2005 |
Alterations in N-methyl-D-aspartate receptor sensitivity and magnesium blockade occur early in development in the R6/2 mouse model of Huntington's disease.
Topics: Animals; Cell Death; Cells, Cultured; Corpus Striatum; Disease Models, Animal; Drug Resistance; Excitatory Amino Acid Agonists; Humans; Huntingtin Protein; Huntington Disease; Magnesium; Membrane Potentials; Mice; Mice, Transgenic; N-Methylaspartate; Nerve Degeneration; Nerve Tissue Proteins; Neurons; Nuclear Proteins; Patch-Clamp Techniques; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 2005 |
Effects of sabiporide, a specific Na+/H+ exchanger inhibitor, on neuronal cell death and brain ischemia.
Topics: Animals; Brain Infarction; Brain Ischemia; Calcium; Cell Death; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Extracellular Space; Glutamic Acid; Guanidines; Mice; N-Methylaspartate; Neurons; Reperfusion; Sodium-Hydrogen Exchangers; Tetrazolium Salts; Thiazoles | 2005 |
Remodelling of spinal nociceptive mechanisms in an animal model of monoarthritis.
Topics: Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Ankle; Arthritis; Disease Models, Animal; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Electric Stimulation; Excitatory Amino Acid Agonists; Freund's Adjuvant; Functional Laterality; Immunohistochemistry; Iontophoresis; Male; Microscopy, Immunoelectron; N-Methylaspartate; Neuronal Plasticity; Neurons; Pain; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Spinal Cord; Substance P; Time Factors | 2005 |
Altered cortical glutamate receptor function in the R6/2 model of Huntington's disease.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Barium; Benzothiadiazines; Cerebral Cortex; Disease Models, Animal; Exons; Huntington Disease; Magnesium; Mice; Mice, Transgenic; N-Methylaspartate; Patch-Clamp Techniques; Pyramidal Cells; Receptors, Glutamate; Time Factors | 2006 |
Kynurenic acid attenuates NMDA-induced pial arteriolar dilation in newborn pigs.
Topics: Analysis of Variance; Animals; Animals, Newborn; Brain Ischemia; Cerebral Arteries; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Hypercapnia; Kynurenic Acid; Male; N-Methylaspartate; Quinolinic Acid; Swine; Time Factors; Vasodilation | 2006 |
Effects of pallidotomy on motor symptoms in an animal model of Parkinson's disease.
Topics: Analysis of Variance; Animals; Disease Models, Animal; Female; Functional Laterality; Globus Pallidus; Medial Forebrain Bundle; Motor Activity; N-Methylaspartate; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Sprague-Dawley; Single-Blind Method; Statistics, Nonparametric; Tyrosine 3-Monooxygenase | 2006 |
Reversal of neuronal migration in a mouse model of fetal alcohol syndrome by controlling second-messenger signalings.
Topics: Animals; Animals, Newborn; Caffeine; Cell Migration Inhibition; Cells, Cultured; Cerebellum; Disease Models, Animal; Dose-Response Relationship, Drug; Ethanol; Female; Fetal Alcohol Spectrum Disorders; Mice; N-Methylaspartate; Neurons; Pregnancy; Second Messenger Systems | 2006 |
Neuroprotective effect of atrial natriuretic peptide against NMDA-induced neurotoxicity in the rat retina.
Topics: Analysis of Variance; Animals; Antibodies; Atrial Natriuretic Factor; Benzazepines; Blotting, Western; Chromatography, High Pressure Liquid; Disease Models, Animal; Domperidone; Dopamine; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Electrochemistry; Excitatory Amino Acid Agonists; Immunohistochemistry; Intracellular Space; Male; N-Methylaspartate; Neuroprotective Agents; Neurotoxicity Syndromes; PC12 Cells; Rats; Rats, Wistar; Retinal Degeneration; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tyrosine 3-Monooxygenase | 2006 |
Transplantation of NGF secreting primary monocytes counteracts NMDA-induced cell death of rat cholinergic neurons in vivo.
Topics: Analysis of Variance; Animals; Antigens, CD; Basal Nucleus of Meynert; Brain Injuries; Cell Death; Cell Survival; Cell Transplantation; Choline O-Acetyltransferase; Disease Models, Animal; Dose-Response Relationship, Drug; Gene Transfer Techniques; In Vitro Techniques; Monocytes; N-Methylaspartate; Nerve Growth Factor; Neurons; Rats; Rats, Sprague-Dawley | 2006 |
Transient and selective overexpression of dopamine D2 receptors in the striatum causes persistent abnormalities in prefrontal cortex functioning.
Topics: Adenylyl Cyclases; Analysis of Variance; Animals; Behavior, Animal; Carbon Isotopes; Cognition Disorders; Corpus Striatum; Deoxyglucose; Disease Models, Animal; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Doxycycline; Excitatory Amino Acid Agonists; Gene Expression; Glucose; Humans; Immunohistochemistry; In Situ Hybridization; Male; Memory, Short-Term; Mice; Mice, Inbred C57BL; Mice, Transgenic; N-Methylaspartate; Prefrontal Cortex; Protein Binding; Proto-Oncogene Proteins c-fos; Radioligand Assay; Reaction Time; Receptors, Dopamine D2; Spiperone; Time Factors; Tritium | 2006 |
NMDA-NR1 and AMPA-GluR4 receptor subunit immunoreactivities in the absence epileptic WAG/Rij rat.
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anterior Thalamic Nuclei; Disease Models, Animal; Electroencephalography; Epilepsy, Absence; Immunohistochemistry; Male; N-Methylaspartate; Rats; Rats, Inbred ACI; Rats, Inbred Strains; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Somatosensory Cortex | 2006 |
Mechanisms and consequences of neuronal stretch injury in vitro differ with the model of trauma.
Topics: Animals; Brain Injuries; Calcium; Cell Culture Techniques; Cell Survival; Disease Models, Animal; Excitatory Amino Acid Agonists; N-Methylaspartate; Neurons; Permeability; Rats; Rats, Sprague-Dawley; Stress, Mechanical; Tensile Strength | 2006 |
Non-fibrillar beta-amyloid abates spike-timing-dependent synaptic potentiation at excitatory synapses in layer 2/3 of the neocortex by targeting postsynaptic AMPA receptors.
Topics: Action Potentials; Age Factors; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Animals, Newborn; Disease Models, Animal; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Gene Expression; Immunohistochemistry; Male; Mice; Mice, Transgenic; N-Methylaspartate; Neocortex; Patch-Clamp Techniques; Pyramidal Cells; Receptors, AMPA; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Synapses; Time Factors | 2006 |
Embryonic stem cell-derived neuron models of Parkinson's disease exhibit delayed neuronal death.
Topics: alpha-Synuclein; Analysis of Variance; Animals; Blotting, Western; Cell Death; Cell Differentiation; Cells, Cultured; Disease Models, Animal; DNA-Binding Proteins; Dose-Response Relationship, Drug; Embryo, Mammalian; Fluorescent Antibody Technique; Humans; Membrane Potentials; Mice; Mice, Inbred C57BL; Mutant Proteins; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Nuclear Receptor Subfamily 4, Group A, Member 2; Oxidative Stress; Parkinson Disease; Patch-Clamp Techniques; Stem Cells; Transcription Factors | 2006 |
Heme oxygenase-1 protects brain from acute excitotoxicity.
Topics: Animals; Animals, Newborn; Brain; Cell Survival; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Embryo, Mammalian; Excitatory Amino Acid Agonists; Heme Oxygenase-1; Mice; Mice, Knockout; N-Methylaspartate; Neurons; Neurotoxicity Syndromes; Receptors, N-Methyl-D-Aspartate | 2006 |
Role of the L-citrulline/L-arginine cycle in iNANC nerve-mediated nitric oxide production and airway smooth muscle relaxation in allergic asthma.
Topics: Allergens; Animals; Arginine; Argininosuccinate Lyase; Argininosuccinate Synthase; Asthma; Citrulline; Disease Models, Animal; Electric Stimulation; Enzyme Inhibitors; Guinea Pigs; Male; Muscle Relaxation; Muscle, Smooth; N-Methylaspartate; Neural Inhibition; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type I; Ovalbumin; Specific Pathogen-Free Organisms; Succinic Acid; Trachea | 2006 |
Rabies virus infection of primary neuronal cultures and adult mice: failure to demonstrate evidence of excitotoxicity.
Topics: Animals; Apoptosis; Caspase 3; Caspase Inhibitors; Cells, Cultured; Cysteine Proteinase Inhibitors; Disease Models, Animal; Excitatory Amino Acid Antagonists; Ketamine; Mice; N-Methylaspartate; Neurons; Oligopeptides; Rabies; Rabies virus | 2006 |
Potential value of changes in cell markers in organotypic hippocampal cultures associated with chronic EtOH exposure and withdrawal: comparison with NMDA-induced changes.
Topics: Animals; Antigens, Nuclear; Biomarkers; Calbindin 1; Calbindins; Cell Division; Central Nervous System Depressants; Disease Models, Animal; Ethanol; Excitatory Amino Acid Agonists; Female; Glial Fibrillary Acidic Protein; Hippocampus; Male; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Organ Culture Techniques; Propidium; Rats; Rats, Sprague-Dawley; S100 Calcium Binding Protein G; Substance Withdrawal Syndrome | 2006 |
Cannabinoids and neuronal damage: differential effects of THC, AEA and 2-AG on activated microglial cells and degenerating neurons in excitotoxically lesioned rat organotypic hippocampal slice cultures.
Topics: Animals; Animals, Newborn; Arachidonic Acids; Brain; Brain Damage, Chronic; Cannabinoids; Cell Count; Disease Models, Animal; Dronabinol; Endocannabinoids; Gliosis; Glycerides; Microglia; N-Methylaspartate; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Organ Culture Techniques; Plant Lectins; Polyunsaturated Alkamides; Rats; Rats, Wistar; Receptor, Cannabinoid, CB2; Treatment Outcome | 2007 |
Maternal IgG suppresses NMDA-induced spasms in infant rats and inhibits NMDA-mediated neurotoxicity in hippocampal neurons.
Topics: Adrenocorticotropic Hormone; Animals; Animals, Suckling; Cells, Cultured; Disease Models, Animal; Excitatory Amino Acid Agonists; Female; Hippocampus; Humans; Immunoglobulin G; Immunotherapy; Infant, Newborn; Male; Milk; N-Methylaspartate; Neurons; Rats; Rats, Wistar; Spasms, Infantile | 2006 |
Apoptotic retinal ganglion cell death in the DBA/2 mouse model of glaucoma.
Topics: Aging; Animals; Annexin A5; Disease Models, Animal; Female; Glaucoma; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; N-Methylaspartate; Retinal Ganglion Cells; Species Specificity | 2007 |
Inhibition of caspase-mediated apoptosis by peroxynitrite in traumatic brain injury.
Topics: Animals; Apoptosis; Blotting, Western; Brain Injuries; Caspases; Cells, Cultured; Cerebral Cortex; Cytochromes c; Disease Models, Animal; Embryo, Mammalian; Enzyme Inhibitors; Immunohistochemistry; In Situ Nick-End Labeling; Male; Mice; Molsidomine; N-Methylaspartate; Neural Inhibition; Neurons; Nitric Oxide Donors; Peroxynitrous Acid; Physical Stimulation; Rats; Rats, Sprague-Dawley; Staurosporine | 2006 |
Prolonged activation of ASIC1a and the time window for neuroprotection in cerebral ischaemia.
Topics: Acid Sensing Ion Channels; Acidosis; Animals; Brain; Brain Ischemia; Cerebral Cortex; Cerebral Ventricles; Cerebrovascular Circulation; Disease Models, Animal; Dose-Response Relationship, Drug; Hydrogen-Ion Concentration; Infarction, Middle Cerebral Artery; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; N-Methylaspartate; Nerve Tissue Proteins; Neuroprotective Agents; Sodium Bicarbonate; Sodium Channels; Spider Venoms; Time Factors | 2007 |
Post-pubertal disruption of medial prefrontal cortical dopamine-glutamate interactions in a developmental animal model of schizophrenia.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Disease Models, Animal; Dopamine; Dopamine Agonists; Electrophysiology; Excitatory Amino Acid Agonists; Female; Glutamic Acid; Hippocampus; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Prefrontal Cortex; Pregnancy; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Schizophrenia | 2007 |
Sex differences in the potency of kappa opioids and mixed-action opioids administered systemically and at the site of inflammation against capsaicin-induced hyperalgesia in rats.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Hyperalgesia; Inflammation; Injections, Intraventricular; Injections, Subcutaneous; Male; N-Methylaspartate; Pain; Pain Measurement; Rats; Rats, Inbred F344; Receptors, Opioid; Sex Factors | 2007 |
Excitotoxic motoneuron disease in chick embryo evolves with autophagic neurodegeneration and deregulation of neuromuscular innervation.
Topics: Age Factors; Animals; Autophagy; Calcitonin Gene-Related Peptide; Calcium; Chick Embryo; Curare; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Gene Expression Regulation, Developmental; Microscopy, Electron, Transmission; Motor Neuron Disease; Motor Neurons; N-Methylaspartate; Nerve Degeneration; Neuromuscular Junction; Neuromuscular Nondepolarizing Agents; Receptors, Nicotinic; Spinal Cord; Tubulin | 2007 |
Mechanisms of the blockade of glutamate channel receptors: significance for structural and physiological investigations.
Topics: Animals; Animals, Newborn; Arecoline; Diamines; Disease Models, Animal; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Hippocampus; Ion Channel Gating; Kainic Acid; Membrane Potentials; Mice; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Quaternary Ammonium Compounds; Rats; Rats, Wistar; Receptors, Glutamate; Tremor | 2007 |
Model of infantile spasms induced by N-methyl-D-aspartic acid in prenatally impaired brain.
Topics: Adrenocorticotropic Hormone; Animals; Animals, Newborn; Betamethasone; Brain; Deoxyglucose; Disease Models, Animal; Drug Administration Schedule; Drug Synergism; Electroencephalography; Female; Fetus; Gestational Age; Glucocorticoids; Humans; Immunohistochemistry; Infant, Newborn; N-Methylaspartate; Pregnancy; Proto-Oncogene Proteins c-fos; Rats; Spasms, Infantile | 2007 |
Complete or partial hippocampal damage produces equivalent retrograde amnesia for remote contextual fear memories.
Topics: Amnesia, Retrograde; Animals; Behavior, Animal; Conditioning, Classical; Disease Models, Animal; Excitatory Amino Acid Agonists; Fear; Freezing Reaction, Cataleptic; Hippocampus; Male; N-Methylaspartate; Rats; Rats, Long-Evans; Retention, Psychology; Time Factors | 2007 |
Beta-amyloid pathology in the entorhinal cortex of rats induces memory deficits: implications for Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cognition Disorders; Disease Models, Animal; Entorhinal Cortex; Exploratory Behavior; Gliosis; Male; Maze Learning; Microinjections; N-Methylaspartate; Neurotoxins; Peptide Fragments; Plaque, Amyloid; Rats; Rats, Wistar; Recognition, Psychology; Statistics, Nonparametric | 2007 |
Oscillatory potentials of the slow-sequence multifocal ERG in primates extracted using the Matching Pursuit method.
Topics: Animals; Disease Models, Animal; Electroretinography; gamma-Aminobutyric Acid; Glaucoma; Macaca; N-Methylaspartate; Photic Stimulation; Pipecolic Acids; Retina; Retinal Ganglion Cells; Signal Processing, Computer-Assisted; Tetrodotoxin | 2007 |
[Experimental techniques for animal models of retinal diseases in mice].
Topics: Animals; Disease Models, Animal; Histological Techniques; Intraocular Pressure; Mice; N-Methylaspartate; Retina; Retinal Diseases | 2007 |
Cocaine-induced decision-making deficits are mediated by miscoding in basolateral amygdala.
Topics: Action Potentials; Amygdala; Animals; Behavior, Animal; Cocaine; Cocaine-Related Disorders; Cues; Decision Making; Discrimination, Psychological; Disease Models, Animal; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Male; Motor Activity; N-Methylaspartate; Neurons; Odorants; Rats; Rats, Long-Evans | 2007 |
Transient allodynia pain models in mice for early assessment of analgesic activity.
Topics: Adrenergic alpha-Antagonists; Amines; Amitriptyline; Analgesics; Animals; Clonidine; Cyclohexanecarboxylic Acids; Dinoprostone; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Excitatory Amino Acid Antagonists; Gabapentin; gamma-Aminobutyric Acid; Hyperalgesia; Injections, Intraperitoneal; Injections, Spinal; Male; Memantine; Mice; Mice, Inbred C57BL; Morphine; N-Methylaspartate; Pain; Peripheral Nervous System; Phenylephrine; Piperazines; Prostaglandin Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Receptors, N-Methyl-D-Aspartate; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP1 Subtype; Reproducibility of Results; Spinal Cord; Spinal Nerves; Time Factors | 2008 |
Neonatal exposure to a combination of N-methyl-D-aspartate and gamma-aminobutyric acid type A receptor anesthetic agents potentiates apoptotic neurodegeneration and persistent behavioral deficits.
Topics: Analgesics; Anesthetics, Combined; Anesthetics, Intravenous; Animals; Animals, Newborn; Anti-Anxiety Agents; Apoptosis; Behavior, Animal; Brain; Diazepam; Disease Models, Animal; Drug Combinations; Drug Synergism; Excitatory Amino Acid Agonists; GABA Antagonists; Ketamine; Male; Maze Learning; Mice; N-Methylaspartate; Neurodegenerative Diseases; Propofol; Receptors, GABA-A; Sodium Chloride; Thiopental; Time Factors | 2007 |
ERK1 plays a critical protective role against N-methyl-D-aspartate-induced retinal injury.
Topics: Animals; Cell Death; Disease Models, Animal; Enzyme Activation; Enzyme-Linked Immunosorbent Assay; Excitatory Amino Acid Agonists; Gene Expression Regulation; Glutamate-Ammonia Ligase; In Situ Nick-End Labeling; Male; Mice; Mice, Knockout; Mitogen-Activated Protein Kinase 3; N-Methylaspartate; Neuroglia; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Retinal Diseases; Signal Transduction; Time Factors | 2008 |
D-serine is a key determinant of glutamate toxicity in amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Disease Models, Animal; Enzyme Activation; Enzyme Induction; Extracellular Signal-Regulated MAP Kinases; Glutamic Acid; Humans; Mice; Mice, Transgenic; Middle Aged; Motor Neurons; Mutation; N-Methylaspartate; Neuroglia; p38 Mitogen-Activated Protein Kinases; Racemases and Epimerases; Serine; Spinal Cord; Superoxide Dismutase; Up-Regulation | 2007 |
A synthetic kainoid, (2S,3R,4R)-3-carboxymethyl-4-(phenylthio)pyrrolidine-2-carboxylic acid (PSPA-1) serves as a novel anti-allodynic agent for neuropathic pain.
Topics: Analgesics; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Glutamic Acid; Hyperalgesia; Immunohistochemistry; Inflammation; Kainic Acid; Mice; Mononeuropathies; N-Methylaspartate; NADPH Dehydrogenase; Nitric Oxide; Nitric Oxide Synthase; Nociceptors; Pain; Spinal Cord; Time Factors | 2007 |
Kynurenic acid inhibits intestinal hypermotility and xanthine oxidase activity during experimental colon obstruction in dogs.
Topics: Animals; Colonic Pseudo-Obstruction; Disease Models, Animal; Dogs; Gastrointestinal Motility; Hemodynamics; Kynurenic Acid; N-Methylaspartate; Nitrates; Nitrites; Peroxidase; Xanthine Oxidase | 2008 |
Evaluation of glutathione metabolism in NMDA preconditioning against quinolinic acid-induced seizures in mice cerebral cortex and hippocampus.
Topics: Analysis of Variance; Animals; Cerebral Cortex; Disease Models, Animal; Drug Interactions; Excitatory Amino Acid Agonists; Glutathione; Glutathione Peroxidase; Glutathione Transferase; Hippocampus; Lipid Peroxidation; Male; Mice; N-Methylaspartate; Quinolinic Acid; Seizures | 2007 |
nNOS-dependent reactivity of cerebral arterioles in Type 1 diabetes.
Topics: Animals; Cerebral Arteries; Diabetes Mellitus, Type 1; Disease Models, Animal; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Kainic Acid; Male; N-Methylaspartate; Nitric Oxide Synthase; Nitroglycerin; Rats; Rats, Sprague-Dawley; Streptozocin; Superoxides | 2007 |
Farnesyl transferase inhibitors induce neuroprotection by inhibiting Ha-Ras signalling pathway.
Topics: Animals; Brain; Cell Survival; Cells, Cultured; Disease Models, Animal; Embryo, Mammalian; Excitatory Amino Acid Agonists; Farnesyltranstransferase; Male; Maleates; Mice; N-Methylaspartate; Neurons; Neuroprotective Agents; Neurotoxicity Syndromes; Proto-Oncogene Proteins p21(ras); Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Signal Transduction; Tetrazolium Salts; Thiazoles | 2007 |
Long-term potentiation of high-frequency oscillation and synaptic transmission characterize in vitro NMDA receptor-dependent epileptogenesis in the hippocampus.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Radiation; Electric Stimulation; Epilepsy; Excitatory Amino Acid Agents; Hippocampus; In Vitro Techniques; Long-Term Potentiation; Magnesium; Male; N-Methylaspartate; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission | 2008 |
Contribution by DRt descending facilitatory pathways to maintenance of spinal neuron sensitization in rats.
Topics: Action Potentials; Animals; Disease Models, Animal; Efferent Pathways; Excitatory Amino Acid Antagonists; Functional Laterality; Hyperalgesia; Ligation; Male; Medulla Oblongata; N-Methylaspartate; Neural Inhibition; Neuralgia; Neurons, Afferent; Nociceptors; Pain Threshold; Peripheral Nervous System Diseases; Physical Stimulation; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Reticular Formation; Sciatic Neuropathy; Spinothalamic Tracts | 2008 |
Mitochondrial sensitivity and altered calcium handling underlie enhanced NMDA-induced apoptosis in YAC128 model of Huntington's disease.
Topics: Animals; Apoptosis; Bongkrekic Acid; Calcium; Calcium Signaling; Cells, Cultured; Cyclosporine; Disease Models, Animal; Excitatory Amino Acid Agonists; Fluorescent Dyes; Huntington Disease; Ionophores; Mice; Mice, Neurologic Mutants; Mitochondria; N-Methylaspartate; Neurotoxins; Patch-Clamp Techniques; Receptors, N-Methyl-D-Aspartate; Trinucleotide Repeat Expansion | 2007 |
Neuroprotective effect of Smilacis chinae rhizome on NMDA-induced neurotoxicity in vitro and focal cerebral ischemia in vivo.
Topics: Animals; Calcium; Cell Death; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Infarction, Middle Cerebral Artery; Male; N-Methylaspartate; Neurons; Neuroprotective Agents; Plant Extracts; Plant Preparations; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Reperfusion Injury; Resveratrol; Rhizome; Smilax; Stilbenes; Time Factors | 2008 |
Multifocal electroretinogram in rhodopsin P347L transgenic pigs.
Topics: Aminobutyrates; Animals; Animals, Genetically Modified; Computers, Handheld; Disease Models, Animal; Electroretinography; Mutation; N-Methylaspartate; Photoreceptor Cells, Vertebrate; Pipecolic Acids; Retinal Bipolar Cells; Retinitis Pigmentosa; Rhodopsin; Swine; Synapses; Synaptic Transmission; Tetrodotoxin; Vision, Ocular | 2008 |
Sigma ligands, but not N-methyl-D-aspartate antagonists, reduce levodopa-induced dyskinesias.
Topics: Adrenergic Agents; Amphetamine; Animals; Anti-Anxiety Agents; Behavior, Animal; Dextromethorphan; Disease Models, Animal; Dopamine Agents; Dyskinesia, Drug-Induced; Excitatory Amino Acid Antagonists; Levodopa; Ligands; Male; N-Methylaspartate; Neurotoxicity Syndromes; Oxidopamine; Pyrimidines; Rats; Rats, Sprague-Dawley; Time Factors | 2008 |
Glutamate-stimulated release of norepinephrine in hippocampal slices of animal models of attention-deficit/hyperactivity disorder (spontaneously hypertensive rat) and depression/anxiety-like behaviours (Wistar-Kyoto rat).
Topics: Animals; Anxiety Disorders; Attention Deficit Disorder with Hyperactivity; Depressive Disorder; Disease Models, Animal; Endocytosis; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; Male; N-Methylaspartate; Norepinephrine; Organ Culture Techniques; Presynaptic Terminals; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Long-Evans; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Species Specificity; Synaptic Transmission | 2008 |
The spatiotemporal pattern of somal and axonal pathology after perikaryal excitotoxic injury to retinal ganglion cells: a histological and morphometric study.
Topics: Analysis of Variance; Animals; Axons; Cell Count; Disease Models, Animal; Excitatory Amino Acid Agonists; Male; N-Methylaspartate; Neurotoxicity Syndromes; Optic Nerve; Rats; Rats, Sprague-Dawley; Retinal Ganglion Cells; Time Factors | 2008 |
A connection between the mitochondrial permeability transition pore, autophagy, and cerebral amyloidogenesis.
Topics: Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloidosis; Animals; Apoptosis; Autophagy; Azasteroids; Brain Diseases; Disease Models, Animal; Dutasteride; Enzyme Inhibitors; Finasteride; Humans; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mitochondrial ADP, ATP Translocases; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; N-Methylaspartate; Neocortex; Neurons; Neuroprotective Agents; Plaque, Amyloid; Potassium Cyanide; Presenilins; Sex Factors; Testosterone | 2008 |
STAT3 activation protects retinal ganglion cell layer neurons in response to stress.
Topics: Adenoviridae; Animals; Cell Survival; Cells, Cultured; Cytoprotection; Disease Models, Animal; Excitatory Amino Acid Agonists; Glutamic Acid; Mice; Mice, Inbred Strains; N-Methylaspartate; Rats; Rats, Long-Evans; Reperfusion Injury; Retinal Diseases; Retinal Ganglion Cells; Retinal Vessels; STAT3 Transcription Factor; Stress, Physiological | 2008 |
Neurotoxic lesions at the ventral mesopontine junction change sleep time and muscle activity during sleep: an animal model of motor disorders in sleep.
Topics: Animals; Behavior, Animal; Brain Stem; Cats; Data Interpretation, Statistical; Disease Models, Animal; Electric Stimulation; Electroencephalography; Excitatory Amino Acid Agonists; Female; Male; Motor Activity; Movement; Muscle, Skeletal; N-Methylaspartate; Polysomnography; Pons; Sleep; Sleep Wake Disorders | 2008 |
Activation of the spinal sigma-1 receptor enhances NMDA-induced pain via PKC- and PKA-dependent phosphorylation of the NR1 subunit in mice.
Topics: Animals; Behavior, Animal; Blotting, Western; Cyclic AMP-Dependent Protein Kinases; Cyclopentanes; Disease Models, Animal; Dose-Response Relationship, Drug; Ethylenediamines; Immunohistochemistry; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Morpholines; N-Methylaspartate; Pain; Pain Measurement; Phosphorylation; Posterior Horn Cells; Protein Kinase C; Receptors, N-Methyl-D-Aspartate; Receptors, sigma; Serine; Sigma-1 Receptor; Signal Processing, Computer-Assisted; Signal Transduction; Spinal Cord; Time Factors | 2008 |
Spinal mediators of hyperalgesia.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Arachidonic Acid; Arginine; Calcium; Cycloleucine; Disease Models, Animal; Excitatory Amino Acids; Hot Temperature; Hyperalgesia; Male; N-Methylaspartate; Neuronal Plasticity; Neurons, Afferent; Neurotoxins; NG-Nitroarginine Methyl Ester; Nitric Oxide; Physical Stimulation; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Stress, Mechanical | 1994 |
Excitatory amino acid neurotransmission through both NMDA and non-NMDA receptors is involved in the anticonvulsant activity of felbamate in DBA/2 mice.
Topics: Acoustic Stimulation; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Binding, Competitive; Disease Models, Animal; Dose-Response Relationship, Drug; Felbamate; Female; Glycine; Injections, Intraperitoneal; Injections, Intraventricular; Kynurenic Acid; Male; Mice; Mice, Inbred DBA; N-Methylaspartate; Phenylcarbamates; Propylene Glycols; Quinoxalines; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Seizures; Serine; Stereoisomerism; Synaptic Transmission | 1994 |
Quantitative and dynamic MRI of neuroprotection in experimental stroke.
Topics: Animals; Brain Ischemia; Cerebrovascular Disorders; Coloring Agents; Disease Models, Animal; Dizocilpine Maleate; Magnetic Resonance Imaging; N-Methylaspartate; Neurons; Neuroprotective Agents; Rabbits; Tetrazolium Salts | 1995 |
Thalamic NMDA receptors in the gamma-hydroxybutyrate model of absence seizures: a cerebral microinjection study in rats.
Topics: Animals; Brain Mapping; Disease Models, Animal; Dizocilpine Maleate; Electroencephalography; Epilepsy, Absence; Hydroxybutyrates; Injections, Spinal; Male; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Thalamus; Time Factors | 1995 |
SB 201823-A antagonizes calcium currents in central neurons and reduces the effects of focal ischemia in rats and mice.
Topics: Animals; Blood Pressure; Calcium; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Cerebellum; Cerebral Infarction; Disease Models, Animal; Glycine; Hippocampus; Ischemic Attack, Transient; Male; Mice; Mice, Inbred Strains; N-Methylaspartate; Neurons; Neuroprotective Agents; Patch-Clamp Techniques; Piperidines; Potassium Chloride; Rats; Rats, Inbred F344; Rats, Inbred Strains; Rats, Sprague-Dawley | 1995 |
Interactions between opioid drugs and propofol in laboratory models of seizures.
Topics: Analgesics, Opioid; Animals; Bicuculline; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Female; Fentanyl; Kainic Acid; Meperidine; Mice; Mice, Inbred Strains; Morphine; N-Methylaspartate; Propofol; Seizures | 1995 |
Modulation of ischemic signal by antagonists of N-methyl-D-aspartate, nitric oxide synthase, and platelet-activating factor in gerbil hippocampus.
Topics: Animals; Blood Platelets; Brain Ischemia; Disease Models, Animal; Dizocilpine Maleate; Gerbillinae; Hippocampus; N-Methylaspartate; Nitric Oxide; Protein Kinase C; Transcription Factor AP-1 | 1995 |
BW1003C87 and NBQX but not CGS19755 reduce glutamate release and cerebral ischemic necrosis.
Topics: Analysis of Variance; Animals; Binding, Competitive; Brain Ischemia; Disease Models, Animal; Glutamic Acid; Hippocampus; Injections, Intraperitoneal; Injections, Intravenous; Male; Microdialysis; N-Methylaspartate; Necrosis; Neurons; Observer Variation; Pipecolic Acids; Prosencephalon; Pyrimidines; Quinoxalines; Random Allocation; Rats; Rats, Wistar; Receptors, AMPA; Reperfusion Injury | 1994 |
The activity of opioid analgesics in seizure models utilizing N-methyl-DL-aspartic acid, kainic acid, bicuculline and pentylenetetrazole.
Topics: Analgesics, Opioid; Animals; Anticonvulsants; Bicuculline; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Kainic Acid; Male; Mice; N-Methylaspartate; Naloxone; Pentylenetetrazole; Seizures | 1994 |
NMDA-GABA interactions in an animal model of behaviour: a gating mechanism from motivation toward psychotic-like symptoms.
Topics: Alprazolam; Animals; Behavior, Animal; Desipramine; Disease Models, Animal; Dizocilpine Maleate; gamma-Aminobutyric Acid; Kindling, Neurologic; Male; Motivation; Motor Activity; Muscimol; N-Methylaspartate; Pentylenetetrazole; Psychotic Disorders; Rats; Rats, Wistar; Swimming | 1994 |
Synthesis, resolution, and SAR of (+/-)-2-amino-N-methyl-alpha-(3-methyl-2-thienyl)benzeneethanamine++ + and related analogs as noncompetitive NMDA antagonists with neuroprotective properties.
Topics: Aniline Compounds; Animals; Anti-Anxiety Agents; Anticonvulsants; Binding, Competitive; Brain Ischemia; Cerebral Infarction; Crystallography, X-Ray; Disease Models, Animal; Gerbillinae; Hippocampus; Isomerism; Male; Mice; Molecular Structure; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship; Thiophenes | 1994 |
Effect of neuroprotective N-methyl-D-aspartate antagonists on increased intracranial pressure: studies in the rat acute subdural hematoma model.
Topics: Acute Disease; Animals; Disease Models, Animal; Dizocilpine Maleate; Hematoma, Subdural; Hemodynamics; Intracranial Pressure; Male; Mannitol; N-Methylaspartate; Pipecolic Acids; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1994 |
Magnesium is more efficacious than phenytoin in reducing N-methyl-D-aspartate seizures in rats.
Topics: Animals; Disease Models, Animal; Female; Magnesium Sulfate; N-Methylaspartate; Phenytoin; Random Allocation; Rats; Rats, Inbred Strains; Seizures | 1994 |
Pharmacological studies on a new dihydrothienopyridine calcium antagonist, S-312-d. 5th communication: anticonvulsant effects in mice.
Topics: Administration, Oral; Animals; Anticonvulsants; Bemegride; Calcium Channel Blockers; Dihydropyridines; Disease Models, Animal; Electroshock; Female; Injections, Subcutaneous; Male; Mice; Mice, Inbred DBA; N-Methylaspartate; Pentylenetetrazole; Picrotoxin; Seizures | 1994 |
Comparison of diffusion-weighted MRI with changes in cell volume in a rat model of brain injury.
Topics: Animals; Brain; Brain Injuries; Cell Size; Cerebral Cortex; Disease Models, Animal; Dizocilpine Maleate; Electric Impedance; Extracellular Space; Magnetic Resonance Imaging; N-Methylaspartate; Rats | 1994 |
Potentiation of N-methyl-D-aspartate-mediated brain injury by a human immunodeficiency virus-1-derived peptide in perinatal rodents.
Topics: AIDS Dementia Complex; Animals; Animals, Newborn; Brain Injuries; Disease Models, Animal; Gene Products, env; Gene Products, gag; Hippocampus; HIV-1; N-Methylaspartate; Rats; Recombinant Fusion Proteins | 1993 |
Stimulation and inhibition of N-methyl-D-aspartate receptors in rats: developing a seizure model.
Topics: Analysis of Variance; Animals; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Electrophysiology; Female; Hippocampus; Injections, Intraperitoneal; Injections, Intraventricular; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Seizures | 1993 |
The facilitatory effect of N-methyl-D-aspartate on sexual receptivity in female rats through GnRH release.
Topics: Animals; Disease Models, Animal; Female; Gonadotropin-Releasing Hormone; Hypogonadism; Hypothalamus; Luteinizing Hormone; N-Methylaspartate; Ovariectomy; Pituitary Gland; Posture; Radioimmunoassay; Rats; Rats, Inbred Strains; Sexual Behavior, Animal; Sodium Glutamate | 1993 |
Experimental neuronal injury in the newborn lamb: a comparison of N-methyl-D-aspartic acid receptor blockade and nitric oxide synthesis inhibition on lesion size and cerebral hyperemia.
Topics: Animals; Animals, Newborn; Arginine; Brain Diseases; Cattle; Disease Models, Animal; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Hemodynamics; Hyperemia; N-Methylaspartate; Neuroprotective Agents; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Receptors, N-Methyl-D-Aspartate; Sheep | 1995 |
Long-duration self-sustained epileptiform activity in the hippocampal-parahippocampal slice: a model of status epilepticus.
Topics: Animals; Diazepam; Disease Models, Animal; Electric Stimulation; Entorhinal Cortex; Hippocampus; In Vitro Techniques; Male; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Status Epilepticus; Time Factors | 1995 |
Traumatic brain damage prevented by the non-N-methyl-D-aspartate antagonist 2,3-dihydroxy-6-nitro-7-sulfamoylbenzo[f] quinoxaline.
Topics: Animals; Brain Injuries; Cerebral Cortex; Disease Models, Animal; Excitatory Amino Acid Antagonists; Hippocampus; Humans; Male; N-Methylaspartate; Nerve Degeneration; Neurons; Piperazines; Quinoxalines; Rats; Rats, Inbred F344; Time Factors; Wounds, Nonpenetrating | 1996 |
Excitotoxic neurotoxicity in an in vitro brain slice model.
Topics: Animals; Apoptosis; Brain; Disease Models, Animal; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; In Vitro Techniques; Ketamine; Mice; N-Methylaspartate; Necrosis; Receptors, N-Methyl-D-Aspartate | 1995 |
Synchronous GABA-mediated potentials and epileptiform discharges in the rat limbic system in vitro.
Topics: 4-Aminopyridine; 6-Cyano-7-nitroquinoxaline-2,3-dione; Analgesics; Animals; Disease Models, Animal; Electrophysiology; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Entorhinal Cortex; Epilepsy; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Hippocampus; Limbic System; Male; Membrane Potentials; N-Methylaspartate; Nerve Fibers; Piperazines; Potassium; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Serotonin Receptor Agonists | 1996 |
Microglial response to N-methyl-D-aspartate-mediated excitotoxicity in the immature rat brain.
Topics: Animals; Brain Ischemia; Disease Models, Animal; Efferent Pathways; Female; Hippocampus; Male; Microglia; N-Methylaspartate; Nerve Degeneration; Rats; Somatosensory Cortex; Thalamus; Wallerian Degeneration | 1996 |
Effects of glucose deprivation on NMDA-induced current and intracellular Ca2+ in rat substantia nigra neurons.
Topics: Animals; Disease Models, Animal; Glucose; Ischemic Attack, Transient; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Potassium Channels; Rats; Rats, Wistar; Substantia Nigra | 1996 |
Magnetic resonance imaging of temporal changes of neurotoxic lesion in the rat.
Topics: Animals; Disease Models, Animal; Evaluation Studies as Topic; Magnetic Resonance Imaging; Male; N-Methylaspartate; Neurotoxins; Rats; Rats, Wistar; Time Factors | 1996 |
A role for synaptic and network plasticity in controlling epileptiform activity in CA1 in the kainic acid-lesioned rat hippocampus in vitro.
Topics: Animals; Disease Models, Animal; Epilepsy; Hippocampus; In Vitro Techniques; Kainic Acid; Male; N-Methylaspartate; Neuronal Plasticity; Rats; Rats, Wistar; Synaptic Transmission | 1996 |
Involvement of nigral glutamatergic inputs in the control of seizures in a genetic model of absence epilepsy in the rat.
Topics: Animals; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Epilepsy, Absence; Glutamic Acid; Male; Microinjections; N-Methylaspartate; Rats; Rats, Wistar; Substantia Nigra | 1996 |
Thalamic NMDA transmission in a genetic model of absence epilepsy in rats.
Topics: Animals; Disease Models, Animal; Dizocilpine Maleate; Epilepsy, Absence; Male; Models, Genetic; N-Methylaspartate; Rats; Thalamus | 1996 |
Age dependence of NMDA receptor involvement in epileptiform activity in rat hippocampal slices.
Topics: Age Factors; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy; Hippocampus; N-Methylaspartate; Rats; Receptors, N-Methyl-D-Aspartate | 1996 |
Involvement of nitric oxide and N-methyl-D-aspartate in acute hypoxic altitude convulsion in mice.
Topics: Acute Disease; Altitude Sickness; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred ICR; N-Methylaspartate; Nitric Oxide; Seizures; Severity of Illness Index; Signal Transduction; Time Factors | 1997 |
Responses to NMDA in cultured hippocampal neurons from trisomy 16 embryonic mice.
Topics: Animals; Cells, Cultured; Disease Models, Animal; Down Syndrome; Evoked Potentials; Excitatory Amino Acid Agonists; Hippocampus; Mice; N-Methylaspartate; Neurons; Patch-Clamp Techniques | 1997 |
N-methyl-D-aspartate-induced excitotoxicity causes myopia in hatched chicks.
Topics: Animals; Chickens; Disease Models, Animal; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Eye; Follow-Up Studies; Injections; Myopia; N-Methylaspartate; Refraction, Ocular; Sensory Deprivation; Vitreous Body | 1997 |
Disruption of spatial but not object-recognition memory by neurotoxic lesions of the dorsal hippocampus in rats.
Topics: Amnesia; Animals; Brain Injuries; Cerebral Cortex; Discrimination Learning; Disease Models, Animal; Excitatory Amino Acid Agonists; Hippocampus; Male; Maze Learning; Memory; N-Methylaspartate; Orientation; Pattern Recognition, Visual; Rats; Rats, Wistar; Temporal Lobe; Time Factors | 1997 |
Design and synthesis of [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)-ethyl]phosphonic acid (EAA-090), a potent N-methyl-D-aspartate antagonist, via the use of 3-cyclobutene-1,2-dione as an achiral alpha-amino acid bioisostere.
Topics: Animals; Azabicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cyclobutanes; Disease Models, Animal; Excitatory Amino Acid Antagonists; Excitatory Amino Acids; Ischemic Attack, Transient; Mice; Models, Chemical; N-Methylaspartate; Organophosphonates; Pipecolic Acids; Piperazines; Rats | 1998 |
Role of glutamate receptor-mediated excitotoxicity in bilirubin-induced brain injury in the Gunn rat model.
Topics: Animals; Apoptosis; Bilirubin; Brain Damage, Chronic; Disease Models, Animal; Dizocilpine Maleate; Drug Synergism; Excitatory Amino Acid Antagonists; Genotype; Glucuronosyltransferase; Injections; Kernicterus; N-Methylaspartate; Neurotoxins; Purkinje Cells; Rats; Rats, Gunn; Receptors, Glutamate; Sulfadimethoxine | 1998 |
Memantine is neuroprotective in a rat model of pressure-induced retinal ischemia.
Topics: Animals; Cell Count; Chromatography, High Pressure Liquid; Disease Models, Animal; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Intraocular Pressure; Ischemia; Male; Memantine; N-Methylaspartate; Ocular Hypertension; Rats; Rats, Sprague-Dawley; Retinal Ganglion Cells; Retinal Vessels; Vitreous Body | 1998 |
West syndrome model: seek and you will find.
Topics: Animals; Disease Models, Animal; Electroencephalography; Excitatory Amino Acid Antagonists; Humans; Infant; N-Methylaspartate; Rats; Spasms, Infantile | 1997 |
Excitotoxin-induced cerebral hyperemia in newborn piglets: regional cerebral blood flow mapping with contrast-enhanced power Doppler US.
Topics: Animals; Animals, Newborn; Area Under Curve; Basal Ganglia; Blood Pressure; Brain Diseases; Brain Ischemia; Carbon Dioxide; Cerebrovascular Circulation; Contrast Media; Corpus Striatum; Disease Models, Animal; Excitatory Amino Acid Agonists; Feasibility Studies; Fluorocarbons; Hyperemia; Hypoxia, Brain; Image Enhancement; Injections; Injections, Intravenous; N-Methylaspartate; Swine; Time Factors; Ultrasonography, Doppler; Vasodilator Agents | 1998 |
Intraspinal injection of adenosine agonists protect against L-NAME induced neuronal loss in the rat.
Topics: Adenosine; Animals; Disease Models, Animal; Drug Interactions; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Injections, Spinal; Male; N-Methylaspartate; Nerve Degeneration; Neuroprotective Agents; NG-Nitroarginine Methyl Ester; Purinergic P1 Receptor Agonists; Purinergic P2 Receptor Agonists; Rats; Rats, Long-Evans; Spinal Cord | 1998 |
Neurotoxic effects of feline immunodeficiency virus, FIV-PPR.
Topics: Acquired Immunodeficiency Syndrome; Animals; Baculoviridae; Brain Chemistry; Calcium; Calcium Signaling; Cats; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; Encephalitis; Excitatory Amino Acid Agonists; Feline Acquired Immunodeficiency Syndrome; Female; Gene Products, env; Glutamic Acid; Immunodeficiency Virus, Feline; L-Lactate Dehydrogenase; N-Methylaspartate; Neurons; Pregnancy; Receptors, N-Methyl-D-Aspartate | 1998 |
Effects of moderate, central fluid percussion traumatic brain injury on nitric oxide synthase activity in rats.
Topics: Analysis of Variance; Animals; Arginine; Blood Pressure; Brain Injuries; Cerebral Cortex; Cerebrovascular Circulation; Disease Models, Animal; Excitatory Amino Acid Agonists; Ionomycin; Ionophores; Male; N-Methylaspartate; Nitric Oxide Synthase; Potassium Chloride; Rats; Rats, Sprague-Dawley | 1998 |
LU 73068, a new non-NMDA and glycine/NMDA receptor antagonist: pharmacological characterization and comparison with NBQX and L-701,324 in the kindling model of epilepsy.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Disease Models, Animal; Dizocilpine Maleate; Drug Synergism; Epilepsy; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Imidazoles; Kindling, Neurologic; Male; Mice; Mice, Inbred Strains; N-Methylaspartate; Quinolones; Quinoxalines; Receptors, AMPA; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Tritium | 1998 |
Effects of the 3-hydroxyanthranilic acid analogue NCR-631 on anoxia-, IL-1 beta- and LPS-induced hippocampal pyramidal cell loss in vitro.
Topics: 3-Hydroxyanthranilic Acid; Animals; Anorexia; Disease Models, Animal; Hippocampus; Immunohistochemistry; Interleukin-1; Lipopolysaccharides; N-Methylaspartate; Organ Culture Techniques; Pyramidal Cells; Rats; Rats, Sprague-Dawley | 1998 |
N-phosphonoalkyl-5-aminomethylquinoxaline-2,3-diones: in vivo active AMPA and NMDA(glycine) antagonists.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Animals; Disease Models, Animal; Electroshock; Hydrobromic Acid; Hydrochloric Acid; Hydroxy Acids; Inhibitory Concentration 50; Mice; N-Methylaspartate; Organophosphonates; Quinoxalines | 1999 |
N-Methyl-D-aspartate antagonists and apoptotic cell death triggered by head trauma in developing rat brain.
Topics: Animals; Apoptosis; Brain; Brain Injuries; Caudate Nucleus; Disease Models, Animal; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Frontal Lobe; Gyrus Cinguli; In Situ Nick-End Labeling; N-Methylaspartate; Nerve Degeneration; Parietal Lobe; Piperazines; Rats; Rats, Wistar; Thalamus; Time Factors | 1999 |
Induction of cyclooxygenase-2 in brain during acute and chronic ethanol treatment and ethanol withdrawal.
Topics: Alcoholic Intoxication; Animals; Behavior, Animal; Brain; Cyclooxygenase 2; Disease Models, Animal; Enzyme Induction; Ethanol; Immunohistochemistry; Isoenzymes; Kainic Acid; Male; N-Methylaspartate; Peroxidases; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome | 1999 |
Anticonvulsant properties of linalool in glutamate-related seizure models.
Topics: Acyclic Monoterpenes; Animals; Anticonvulsants; Cerebral Cortex; Disease Models, Animal; Dizocilpine Maleate; Glutamic Acid; Kindling, Neurologic; Male; Monoterpenes; N-Methylaspartate; Pentylenetetrazole; Phenobarbital; Quinolinic Acid; Radioligand Assay; Rats; Rats, Wistar; Seizures; Terpenes | 1999 |
Age-specific N-methyl-D-aspartate-induced seizures: perspectives for the West syndrome model.
Topics: Age Factors; Animals; Behavior, Animal; Disease Models, Animal; Electroencephalography; Humans; Hydrocortisone; N-Methylaspartate; Pyridoxine; Rats; Seizures; Spasms, Infantile; Valproic Acid | 1999 |
Involvement of peripheral NMDA and non-NMDA receptors in development of persistent firing of spinal wide-dynamic-range neurons induced by subcutaneous bee venom injection in the cat.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Bee Venoms; Cats; Disease Models, Animal; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Injections, Subcutaneous; Male; N-Methylaspartate; Nociceptors; Pain; Posterior Horn Cells; Quinoxalines; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate | 1999 |
NMDA- but not kainate-mediated events reduce efficacy of some antiepileptic drugs against generalized tonic-clonic seizures in mice.
Topics: Animals; Anticonvulsants; Carbamazepine; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Electroshock; Epilepsy, Tonic-Clonic; Kainic Acid; Male; Mice; N-Methylaspartate; Phenobarbital; Phenytoin; Receptors, N-Methyl-D-Aspartate; Valproic Acid | 1999 |
Disruption of prepulse inhibition following N-methyl-D-aspartate infusion into the ventral hippocampus is antagonized by clozapine but not by haloperidol: a possible model for the screening of atypical antipsychotics.
Topics: Acoustic Stimulation; Animals; Antipsychotic Agents; Clozapine; Disease Models, Animal; Excitatory Amino Acid Antagonists; Haloperidol; Hippocampus; Infusions, Parenteral; Male; N-Methylaspartate; Rats; Rats, Wistar; Reflex, Startle | 1999 |
Induction of a 55-kDa PKN cleavage product by ischemia/reperfusion model in the rat retina.
Topics: Animals; Apoptosis; Caspase 3; Caspase Inhibitors; Disease Models, Animal; Fluorescent Antibody Technique, Indirect; Immunoblotting; Male; Molecular Weight; N-Methylaspartate; Oligopeptides; Protein Kinase C; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Rats; Rats, Wistar; Reperfusion Injury; Retinal Diseases | 2000 |
Inhibition of TNF-alpha can attenuate or exacerbate excitotoxic injury in neonatal rat brain.
Topics: Animals; Animals, Newborn; Atrophy; Brain; Brain Injuries; Carrier Proteins; Corpus Striatum; Disease Models, Animal; Drug Synergism; Excitatory Amino Acid Agonists; Hippocampus; Inflammation; N-Methylaspartate; Neurotoxins; Rats; Rats, Sprague-Dawley; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type I; Tumor Necrosis Factor Decoy Receptors; Tumor Necrosis Factor-alpha | 2000 |
Organization of cortico-cortical associative projections in a rat model of microgyria.
Topics: Animals; Animals, Newborn; Axonal Transport; Biotin; Brain; Cerebral Cortex; Dextrans; Disease Models, Animal; Fluorescent Dyes; Frontal Lobe; N-Methylaspartate; Neural Pathways; Neurons; Rats; Rats, Wistar | 2000 |
N-Methyl-D-aspartic acid- and metaphit-induced audiogenic seizures in rat model of seizures.
Topics: Animals; Disease Models, Animal; Electroencephalography; Male; N-Methylaspartate; Phencyclidine; Rats; Rats, Wistar; Seizures | 2000 |
Retinal damage after 3 to 4 months of elevated intraocular pressure in a rat glaucoma model.
Topics: Animals; Cell Death; Cell Nucleus; Disease Models, Animal; DNA Fragmentation; Electroretinography; Female; Fluorescent Dyes; Glaucoma, Open-Angle; Intraocular Pressure; Membrane Potentials; Microscopy, Confocal; Microscopy, Fluorescence; Mitochondria; N-Methylaspartate; Rats; Rats, Wistar; Retinal Diseases; Retinal Ganglion Cells; Stilbamidines; Time Factors | 2000 |
A common signaling pathway for striatal NMDA and adenosine A2a receptors: implications for the treatment of Parkinson's disease.
Topics: 3,4-Dihydroxyphenylacetic Acid; Analysis of Variance; Animals; Corpus Striatum; Cyclic AMP; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; In Vitro Techniques; Male; N-Methylaspartate; Neuroprotective Agents; Oxidopamine; Parkinson Disease, Secondary; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Receptors, N-Methyl-D-Aspartate; Receptors, Purinergic P1; Signal Transduction | 2000 |
NOC/oFQ contributes to age-dependent impairment of NMDA-induced cerebrovasodilation after brain injury.
Topics: Aging; Animals; Animals, Newborn; Arterioles; Blood Pressure; Brain Injuries; Cerebrovascular Circulation; Disease Models, Animal; Excitatory Amino Acids; Female; Glutamic Acid; Male; N-Methylaspartate; Narcotic Antagonists; Nociceptin; Nociceptin Receptor; Opioid Peptides; Peptide Fragments; Pia Mater; Receptors, Opioid; Swine; Vasoconstriction; Vasodilation; Wounds, Nonpenetrating | 2000 |
Presenilin-1 regulates the neuronal threshold to excitotoxicity both physiologically and pathologically.
Topics: Alzheimer Disease; Animals; Brain; Cells, Cultured; Disease Models, Animal; Excitatory Amino Acid Agonists; Gene Expression; Humans; Infarction, Middle Cerebral Artery; Kainic Acid; Membrane Proteins; Mice; Mice, Knockout; Mice, Transgenic; N-Methylaspartate; Nerve Degeneration; Neurons; Presenilin-1 | 2000 |
The N-methyl-D-aspartate antagonistic and opioid components of d-methadone antinociception in the rat spinal cord.
Topics: Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analgesia; Analgesics, Opioid; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Methadone; N-Methylaspartate; Naloxone; Nociceptors; Pain; Pain Measurement; Pain Threshold; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 2000 |
Chemical kindling and seizure susceptibility in morphine dependent rats.
Topics: Animals; Caffeine; Convulsants; Disease Models, Animal; Drug Interactions; Excitatory Amino Acid Agonists; GABA Antagonists; Kindling, Neurologic; Male; Morphine; Morphine Dependence; N-Methylaspartate; Pentylenetetrazole; Picrotoxin; Rats; Rats, Wistar; Receptors, GABA; Receptors, Purinergic P1; Seizures | 2000 |
Effects of experimental glaucoma in macaques on the multifocal ERG. Multifocal ERG in laser-induced glaucoma.
Topics: Animals; Disease Models, Animal; Electroretinography; Glaucoma; Injections; Intraocular Pressure; Macaca mulatta; N-Methylaspartate; Retina; Tetrodotoxin; Visual Field Tests; Vitreous Body | 2000 |
Accumulation of the anandamide precursor and other N-acylethanolamine phospholipids in infant rat models of in vivo necrotic and apoptotic neuronal death.
Topics: Animals; Apoptosis; Arachidonic Acids; Brain Injuries; Cerebral Cortex; Corpus Striatum; Disease Models, Animal; Dizocilpine Maleate; Endocannabinoids; Ethanolamines; Male; N-Methylaspartate; Necrosis; Neurodegenerative Diseases; Neurons; Phospholipids; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Species Specificity; Wounds, Nonpenetrating | 2001 |
Potentiation of DOM-induced stimulus control by non-competitive NMDA antagonists: a link between the glutamatergic and serotonergic hypotheses of schizophrenia.
Topics: Animals; Discrimination Learning; Disease Models, Animal; Dizocilpine Maleate; DOM 2,5-Dimethoxy-4-Methylamphetamine; Dose-Response Relationship, Drug; Drug Synergism; Excitatory Amino Acid Antagonists; Hallucinogens; Ketamine; Male; N-Methylaspartate; Phencyclidine; Rats; Rats, Inbred F344; Schizophrenia | 2000 |
Facilitation of NMDA-induced currents and Ca2+ transients in the rat substantia gelatinosa neurons after ligation of L5-L6 spinal nerves.
Topics: Animals; Calcium Signaling; Cell Membrane; Denervation; Disease Models, Animal; Dose-Response Relationship, Drug; Lumbar Vertebrae; Membrane Potentials; N-Methylaspartate; Neurons, Afferent; Pain; Peripheral Nervous System Diseases; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Nerves; Substantia Gelatinosa; Synaptic Transmission | 2000 |
Subtle alterations in NMDA-stimulated cyclic GMP levels following lateral fluid percussion brain injury.
Topics: Animals; Brain Injuries; Cognition Disorders; Cyclic GMP; Disease Models, Animal; Functional Laterality; Hippocampus; Male; N-Methylaspartate; Percussion; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Time Factors | 2001 |
Increased expression of NR2A subunit does not alter NMDA-evoked responses in cultured fetal trisomy 16 mouse hippocampal neurons.
Topics: Animals; Chromosome Mapping; Diploidy; Disease Models, Animal; Down Syndrome; Evoked Potentials; Female; Heterozygote; Hippocampus; Humans; Male; Membrane Potentials; Mice; Mice, Mutant Strains; N-Methylaspartate; Neurons; Receptors, N-Methyl-D-Aspartate; Spermine; Trisomy; Zinc | 2001 |
Increases in cortical glutamate concentrations in transgenic amyotrophic lateral sclerosis mice are attenuated by creatine supplementation.
Topics: Amino Acid Transport System X-AG; Animals; ATP-Binding Cassette Transporters; Biological Transport; Body Weight; Brain Chemistry; Creatine; Dicarboxylic Acids; Disease Models, Animal; Excitatory Amino Acid Agonists; Glutamic Acid; Glutamine; Magnetic Resonance Spectroscopy; Male; Mice; Mice, Transgenic; Microdialysis; Motor Activity; Motor Neuron Disease; N-Methylaspartate; Neurotransmitter Uptake Inhibitors; Oxidative Stress; Psychomotor Performance; Pyrrolidines; Superoxide Dismutase | 2001 |
PKCgamma contributes to a subset of the NMDA-dependent spinal circuits that underlie injury-induced persistent pain.
Topics: Action Potentials; Animals; Behavior, Animal; Disease Models, Animal; Excitatory Amino Acid Antagonists; Hyperalgesia; Isoenzymes; Mice; Mice, Knockout; Mustard Plant; N-Methylaspartate; Neuralgia; Pain Measurement; Physical Stimulation; Plant Extracts; Plant Oils; Posterior Horn Cells; Protein Kinase C; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 2001 |
Anticonvulsant activity of N-palmitoylethanolamide, a putative endocannabinoid, in mice.
Topics: Amides; Animals; Anticonvulsants; Cannabinoid Receptor Modulators; Cannabinoids; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Endocannabinoids; Ethanolamines; Male; Mice; N-Methylaspartate; Palmitic Acids; Propionates; Seizures; Valproic Acid | 2001 |
Altered content and modulation of soluble guanylate cyclase in the cerebellum of rats with portacaval anastomosis.
Topics: Animals; Cerebellum; Cyclic GMP; Disease Models, Animal; Enzyme Activators; Excitatory Amino Acid Agonists; Glutamic Acid; Guanylate Cyclase; Hepatic Encephalopathy; Hyperammonemia; Immunoblotting; Indazoles; Lymphocytes; Male; Microdialysis; N-Methylaspartate; Nitric Oxide; Nitric Oxide Donors; Penicillamine; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; S-Nitroso-N-Acetylpenicillamine; Synaptic Transmission | 2001 |
Neuroprotective properties of the novel antiepileptic drug levetiracetam in the rat middle cerebral artery occlusion model of focal cerebral ischemia.
Topics: Animals; Anticonvulsants; Arterial Occlusive Diseases; Body Temperature; Brain; Brain Ischemia; Cerebrovascular Circulation; Disease Models, Animal; Dizocilpine Maleate; Levetiracetam; Male; Middle Cerebral Artery; N-Methylaspartate; Neuroprotective Agents; Piracetam; Rats; Rats, Wistar | 2001 |
The acute antihyperalgesic action of nonsteroidal, anti-inflammatory drugs and release of spinal prostaglandin E2 is mediated by the inhibition of constitutive spinal cyclooxygenase-2 (COX-2) but not COX-1.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Disease Models, Animal; Dose-Response Relationship, Drug; Hyperalgesia; Ibuprofen; Injections, Intraperitoneal; Injections, Spinal; Isoenzymes; Male; Membrane Proteins; N-Methylaspartate; Pain Measurement; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rats; Rats, Sprague-Dawley; Spinal Cord; Substance P | 2001 |
Amphetamine-induced plasticity of AMPA receptors in the ventral tegmental area: effects on extracellular levels of dopamine and glutamate in freely moving rats.
Topics: Amphetamine; Amphetamine-Related Disorders; Animals; Disease Models, Animal; Dopamine; Extracellular Space; Glutamic Acid; Male; Microdialysis; Microinjections; N-Methylaspartate; Neuronal Plasticity; Neurons; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Synaptic Transmission; Ventral Tegmental Area; Wakefulness | 2001 |
Astrocytic factors protect neuronal integrity and reduce microglial activation in an in vitro model of N-methyl-D-aspartate-induced excitotoxic injury in organotypic hippocampal slice cultures.
Topics: Animals; Astrocytes; Brain Injuries; Cell Communication; Cell Death; Cell Size; Cells, Cultured; Culture Media, Conditioned; Dentate Gyrus; Disease Models, Animal; Down-Regulation; Excitatory Amino Acid Agonists; Fluorescein-5-isothiocyanate; Gliosis; Growth Substances; Hippocampus; Lectins; Microglia; Microscopy, Confocal; N-Methylaspartate; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Rats; Rats, Wistar; Transforming Growth Factor beta | 2001 |
Long-lasting aberrant tubulovesicular membrane inclusions accumulate in developing motoneurons after a sublethal excitotoxic insult: a possible model for neuronal pathology in neurodegenerative disease.
Topics: Animals; Brefeldin A; Cell Compartmentation; Chick Embryo; Disease Models, Animal; Endoplasmic Reticulum; Endosomes; Golgi Apparatus; Inclusion Bodies; Intracellular Membranes; Lysosomes; Membrane Proteins; Microscopy, Electron; Microtubules; Motor Neuron Disease; Motor Neurons; N-Methylaspartate; Neuromuscular Junction; Presenilin-1; Protein Synthesis Inhibitors; Spinal Cord; trans-Golgi Network; Vacuoles | 2001 |
Modeling Huntington's disease in cells, flies, and mice.
Topics: Animals; Animals, Genetically Modified; Apoptosis; Caenorhabditis elegans; Cell Line, Transformed; Cells, Cultured; Corpus Striatum; Cysteine Endopeptidases; Disease Models, Animal; Drosophila melanogaster; Embryonic and Fetal Development; Fetal Proteins; Genes, Dominant; Genes, Lethal; Haplorhini; Humans; Huntingtin Protein; Huntington Disease; Kidney; Mice; Mice, Knockout; Mice, Transgenic; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Nuclear Proteins; PC12 Cells; Peptide Fragments; Protein Interaction Mapping; Rats; Trinucleotide Repeats | 2001 |
NMDA receptor function in mouse models of Huntington disease.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Behavior, Animal; Calcium Channels; Calcium Signaling; Disease Models, Animal; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Huntington Disease; Immunohistochemistry; Ion Channels; Membrane Potentials; Mice; Mice, Neurologic Mutants; Mice, Transgenic; Mutation; N-Methylaspartate; Neostriatum; Neurons; Organ Culture Techniques; Patch-Clamp Techniques; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 2001 |
Nociceptin, OP4 receptor ligand in different models of experimental epilepsy.
Topics: Animals; Bicuculline; Disease Models, Animal; Electric Stimulation; Epilepsy; Female; Mice; N-Methylaspartate; Nociceptin; Nociceptin Receptor; Opioid Peptides; Pentylenetetrazole; Receptors, Opioid | 2002 |
Increased sensitivity to N-methyl-D-aspartate receptor-mediated excitotoxicity in a mouse model of Huntington's disease.
Topics: Animals; Caspase 3; Caspases; Cell Death; Cells, Cultured; Corpus Striatum; Disease Models, Animal; Humans; Huntingtin Protein; Huntington Disease; In Situ Nick-End Labeling; In Vitro Techniques; Mice; Mice, Transgenic; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Nuclear Proteins; Patch-Clamp Techniques; Receptors, N-Methyl-D-Aspartate | 2002 |
Alzheimer amyloid beta-peptide inhibits the late phase of long-term potentiation through calcineurin-dependent mechanisms in the hippocampal dentate gyrus.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Calcineurin; Cyclosporine; Dentate Gyrus; Disease Models, Animal; Hippocampus; Immunosuppressive Agents; Long-Term Potentiation; Male; N-Methylaspartate; Phospholipids; Rats; Rats, Sprague-Dawley; Tacrolimus | 2002 |
NS 1231, a novel compound with neurotrophic-like effects in vitro and in vivo.
Topics: Animals; Cell Survival; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Enzyme Activation; Gerbillinae; Hippocampus; In Vitro Techniques; Indoles; Infarction, Middle Cerebral Artery; Ischemic Attack, Transient; Mice; Mitogen-Activated Protein Kinases; N-Methylaspartate; Nerve Growth Factor; Nerve Growth Factors; Neurites; Neurons; Neuroprotective Agents; Oximes; PC12 Cells; Phosphorylation; Rats; Receptor, trkA; Signal Transduction | 2002 |
Studies on the spinal interaction of morphine and the NMDA antagonist MK-801 on the hyperesthesia observed in a rat model of sciatic mononeuropathy.
Topics: Animals; Disease Models, Animal; Dizocilpine Maleate; Drug Interactions; Hot Temperature; Hyperesthesia; Injections, Spinal; Male; Morphine; N-Methylaspartate; Pain; Peripheral Nervous System Diseases; Rats; Rats, Inbred Strains; Sciatic Nerve; Spinal Cord; Time Factors | 1992 |
Responses to N-methyl-D-aspartate are enhanced in rats with petit mal-like seizures.
Topics: Amino Acids; Animals; Disease Models, Animal; Electric Stimulation; Epilepsy, Absence; Evoked Potentials, Somatosensory; In Vitro Techniques; Iontophoresis; Male; Motor Cortex; N-Methylaspartate; Rats; Rats, Inbred Strains; Somatosensory Cortex; Synapses | 1992 |
Neuroprotective effects of L-kynurenine on hypoxia-ischemia and NMDA lesions in neonatal rats.
Topics: Animals; Animals, Newborn; Brain Ischemia; Cerebral Cortex; Disease Models, Animal; Dose-Response Relationship, Drug; Kynurenic Acid; Kynurenine; N-Methylaspartate; Probenecid; Proto-Oncogene Proteins c-fos; Rats; Rats, Inbred Strains | 1992 |
A mouse model of focal cerebral ischemia for screening neuroprotective drug effects.
Topics: Animals; Brain Ischemia; Calcium Channel Blockers; Cerebral Arteries; Cerebral Infarction; Disease Models, Animal; Drug Evaluation, Preclinical; Electrocoagulation; Male; Mice; N-Methylaspartate; Serotonin | 1992 |
Synergistic interactions between muscarinic antagonists, adrenergic agonists and NMDA antagonists with respect to locomotor stimulatory effects in monoamine-depleted mice.
Topics: Adrenergic alpha-Agonists; Animals; Atropine; Biperiden; Clonidine; Disease Models, Animal; Dizocilpine Maleate; Drug Synergism; Ketamine; Male; Methyldopa; Mice; Mice, Neurologic Mutants; Motor Activity; N-Methylaspartate; Parasympatholytics; Parkinson Disease; Piperazines | 1991 |
Neuroprotective properties of 5-HT1A receptor agonists in rodent models of focal and global cerebral ischemia.
Topics: Animals; Body Temperature; Brain; Brain Ischemia; Disease Models, Animal; Hypothalamus, Posterior; Ischemic Attack, Transient; Male; Mice; N-Methylaspartate; Phencyclidine; Pyridines; Rats; Rats, Inbred Strains; Receptors, Serotonin | 1991 |
A slow intravenous infusion of N-methyl-DL-aspartate as a seizure model in the mouse.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Infusions, Intravenous; Injections, Intraventricular; Male; Mice; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Seizures; Serine; Spermidine | 1991 |
NMDA-sensitive L-[3H]glutamate binding in cerebral cortex of El mice.
Topics: Animals; Cerebral Cortex; Disease Models, Animal; Disease Susceptibility; Epilepsy; Genetic Predisposition to Disease; Glutamates; Membranes; Mice; Mice, Inbred Strains; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Tritium | 1990 |
Involvement of NMDA receptors in non-convulsive epilepsy in WAG/Rij rats.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Combinations; Electroencephalography; Epilepsy; Female; Injections, Intraventricular; Male; N-Methylaspartate; Rats; Rats, Mutant Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
Comparison of phenytoin with noncompetitive N-methyl-D-aspartate antagonists in a model of focal brain ischemia in rat.
Topics: Animals; Brain Ischemia; Disease Models, Animal; Dizocilpine Maleate; Male; N-Methylaspartate; Phencyclidine; Phenytoin; Rats; Rats, Inbred F344 | 1990 |
NMDA depolarizations and long-term potentiation are reduced in the aged rat neocortex.
Topics: Aging; Alzheimer Disease; Animals; Cerebral Cortex; Disease Models, Animal; Electric Stimulation; In Vitro Techniques; Membrane Potentials; N-Methylaspartate; Neurons; Rats; Rats, Inbred F344; Time Factors | 1990 |
NMDA antagonists differentiate epileptogenesis from seizure expression in an in vitro model.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Aspartic Acid; Dibenzocycloheptenes; Disease Models, Animal; Dizocilpine Maleate; Electric Stimulation; Electrophysiology; Epilepsy; Evoked Potentials; Hippocampus; In Vitro Techniques; N-Methylaspartate; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures; Valine | 1989 |
A potential role for excitotoxins in the pathophysiology of spinal cord injury.
Topics: Animals; Anticonvulsants; Aspartic Acid; Dibenzocycloheptenes; Disease Models, Animal; Dizocilpine Maleate; Male; Motor Activity; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Spinal Cord Injuries; Stereoisomerism; Toxins, Biological | 1988 |
Focal cerebral ischaemia in the cat: treatment with the glutamate antagonist MK-801 after induction of ischaemia.
Topics: Animals; Anticonvulsants; Aspartic Acid; Brain Ischemia; Cats; Dibenzocycloheptenes; Disease Models, Animal; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; N-Methylaspartate | 1988 |
An animal model for neuron-specific spinal cord lesions by the microinjection of N-methylaspartate, kainic acid, and quisqualic acid.
Topics: Animals; Aspartic Acid; Disease Models, Animal; Forelimb; Ganglia, Spinal; Hindlimb; Kainic Acid; N-Methylaspartate; Neurons; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Glutamate; Receptors, Neurotransmitter; Spinal Cord; Synaptic Transmission | 1985 |