n-methylaspartate has been researched along with Brain Ischemia in 228 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (6.14) | 18.7374 |
| 1990's | 99 (43.42) | 18.2507 |
| 2000's | 82 (35.96) | 29.6817 |
| 2010's | 29 (12.72) | 24.3611 |
| 2020's | 4 (1.75) | 2.80 |
| Authors | Studies |
|---|---|
| Chao, LC; Huang, CC; Huang, SY; Lee, AH; Lee, EJ; Lin, YW; Shan, YS; Tai, SH; Wu, TS | 1 |
| Cheng, M; He, Y; Liu, J; Ma, C; Qin, F; Quan, J; Yang, H; Zhao, Y | 1 |
| Hayashi, H; Inoue, D; Iwatani, Y; Ohata, M; Sato, S; Suzuki, K; Takagi, N; Yamada, M; Yuan, B | 1 |
| Ayuso-Dolado, S; Díaz-Guerra, M; Esteban-Ortega, GM; Vidaurre, ÓG | 1 |
| Furuichi, T; Hayashi, K; Muto, Y; Sadakata, T; Sato, Y; Shinoda, Y; Shiraishi-Yamaguchi, Y | 1 |
| Almeida, A; Arenillas, JF; Colàs-Campàs, L; Cortijo Garcia, E; de Lera Alfonso, M; Delgado-Esteban, M; Purroy, F; Ramos-Araque, ME; Rodriguez, C; Sanchez Barba, M; Vecino, R | 1 |
| Anwar, MA; Lloyd-Burton, SM; Roskams, AJ; Vincent, AJ; York, EM | 1 |
| Dong, Z; Girling, K; Lee, W; Lin, SZ; Shyu, WC; Taghibiglou, C; Wang, YT; Zhang, S | 1 |
| Ahlgren, H; Bading, H; Bas-Orth, C; Freitag, HE; Hellwig, A; Ottersen, OP | 1 |
| Alberch, J; Ceña, V; Collon, KW; Domercq, M; Fernández-Díez, B; Franco, R; Giralt, A; Giralt, E; Gottlieb, M; Lopez, I; Martínez-Pinilla, E; Matute, C; Moreno, B; Parent, JM; Posadas, I; Sánchez-Gómez, MV; Teixido, M; Villoslada, P; Zhang, H | 1 |
| Li, YJ; Liu, SB; Wu, YM; Yang, L; Yang, Q; Zhang, K; Zhao, MG; Zheng, LH | 1 |
| Wang, ES; Wu, F; Yu, G | 1 |
| Guo, HL; Guo, YY; Li, XB; Liu, SB; Shi, TY; Wang, M; Wu, YM; Yang, L; Zhang, K; Zhao, MG | 1 |
| Chen, X; Hu, H; Huang, Y; Leng, T; Li, Q; Liu, A; Qiu, P; Su, X; Wang, Y; Xiong, ZG; Yan, G; Yin, W; Zhang, J; Zhou, S; Zhou, Y; Zhu, W | 1 |
| Attwell, D; Hamilton, NB; Kolodziejczyk, K; Kougioumtzidou, E | 1 |
| Chu, K; Li, H; Que, J; Xu, W; Ye, M; Zhang, Y | 1 |
| Aronow, B; Bouras, C; Boze, H; Charnay, Y; Giannakopoulos, P; Hakkoum, D; Imhof, A; Moulin, G; Stoppini, L; Vallet, PG | 1 |
| Abraini, JH; Chazalviel, L; David, HN; Haelewyn, B; Lecocq, M; Lemaire, M; Risso, JJ; Rouillon, C | 1 |
| Du, CP; Gao, J; Hou, XY; Liu, Y; Qi, J; Tai, JM; Wang, W | 1 |
| Chi, OZ; Hunter, C; Liu, X; Weiss, HR | 1 |
| Benveniste, H | 1 |
| André, VM; Deng, Y; Figueroa, BE; Friedlander, R; Graham, RK; Hayden, MR; Joshi, P; Leavitt, BR; Levine, MS; Lu, G; Metzler, M; Pouladi, MA; Raymond, L; Slow, EJ; Wu, NP | 1 |
| Cimarosti, H; Henley, JM; Kantamneni, S | 1 |
| Clarke, PG; Puyal, J; Vaslin, A | 1 |
| Deng, J; Ge, J; Takemori, H; Teng, LL; Wang, JW; Xiong, ZQ; Zhang, XL; Zhou, Y | 1 |
| Clarke, PG; Rummel, C; Vaslin, A | 1 |
| Ahmad, AS; Doré, S; Maruyama, T; Narumiya, S; Saleem, S | 1 |
| Bari, F; Domoki, F; Lenti, L; Müller, RH; Pardeike, J; Tóth-Szuki, V; Zimmermann, A | 1 |
| Agin, V; Ali, C; Castel, H; Dauphinot, L; Hommet, Y; Jullienne, A; Macrez, R; Maubert, E; Montaner, J; Munuera, J; Plawinski, L; Potier, MC; Roussel, BD; Vivien, D; Yepes, M | 1 |
| Iwata, Y; Jonas, RA; Nicole, O; Okamura, T; Zurakowski, D | 1 |
| Aronowski, J; Grotta, JC; Palusinski, R; Piriyawat, P; Strong, R; Zhao, X | 1 |
| Arjunan, P; Becker, KG; Cao, Y; Ding, H; Dong, L; Fariss, RN; Hou, X; Kumar, A; Lee, C; Lennartsson, J; Li, X; Li, Y; Nagai, N; Tang, Z; Wang, B; Wardega, P; Zhang, F; Zhang, SZ; Zhang, Y | 1 |
| Han, T; Li, J; Liang, P; Liu, T; Liu, X; Liu, XY; Su, P; Wang, KW; Wang, Y; Yin, DM; Zhang, B; Zhang, Y; Zhou, Z; Zhu, YB | 1 |
| Bassell, GJ; Cooper-Morgan, A; Florman, H; Jin, G; Kan, MC; Oruganty-Das, A; Richter, JD; Swanger, SA; van Leyen, K | 1 |
| Belousov, AB; Denisova, JV; Fontes, JD; Kang, KS; Wang, Y; Zhu, BT | 1 |
| Fukunaga, K; Shioda, N | 1 |
| Culmsee, C; D'Orsi, B; Dolga, AM; Eisel, UL; Kepura, F; Knaus, HG; Nijholt, IM; Plant, T; Plesnila, N; Prehn, JH; Terpolilli, N | 1 |
| Bromberg, Y; Navon, H; Shani, E; Sperling, O | 1 |
| Bai, Y; Chen, L; Li, L; Qi, J; Qi, Z; Sun, K; Yang, R; Zhang, Z; Zhou, L | 1 |
| Baudry, M; Chen, JC; Davis, DA; Finch, CE; Hsu, YT; Iwata, N; Kam, W; Morgan, TE; Ning, Z; Petasis, NA; Sioutas, C; Snyder, D; Tanner, JA; Winkler, JW | 1 |
| O'Connor, JJ; Watters, O | 1 |
| Cho, IH; Hong, HS; Kim, HS; Lee, CK; Lee, JM; Lee, KS; Noh, SJ; Suh, YH | 1 |
| Cho, GS; Choi, IY; Choi, WJ; Hwang, S; Jeong, LS; Ju, C; Kim, WK; Lee, HW; Lee, JC | 1 |
| Ahlgren, H; Henjum, K; Ottersen, OP; Rundén-Pran, E | 1 |
| Abraini, JH; Colomb, DG; David, HN; Degoulet, M; Haelewyn, B; Risso, JJ | 1 |
| Bae, ON; Baek, SH; Hejabian, S; Kassab, M; Lee, KY; Majid, A; Min, J; Rajanikant, K; Serfozo, K; Smith, J | 1 |
| Bösel, J; Djoufack, PC; Endres, M; Fink, KB; Paehr, M; Weissbrich, C | 1 |
| Aarts, M; Arundine, M; Besshoh, S; Gurd, JW; Liu, L; Liu, Y; Salter, MW; Tymianski, M; Wang, YT | 1 |
| Busija, DW; Domoki, F; Perciaccante, JV; Puskar, M | 1 |
| Benchenane, K; Chuquet, J; MacKenzie, ET; Roussel, S; Toutain, J; Touzani, O | 1 |
| Aono, M; Bennett, ER; Kim, KS; Laskowitz, DT; Lynch, JR; Myers, J; Pearlstein, RD; Warner, DS | 1 |
| Armstead, WM; Philip, S | 1 |
| Baimbridge, KG; Fernandes, HB; Krebs, C; Raymond, LA; Sheldon, C | 1 |
| Akerman, KE; Chan, PH; Koistinaho, J; Koponen, S; Kurkinen, K; Mochly-Rosen, D | 1 |
| Oja, SS; Saransaari, P | 2 |
| Frantseva, MV; Kokarovtseva, L; Perez Velazquez, JL; Weisspapir, M | 1 |
| Bogousslavsky, J; Bonny, C; Borsello, T; Clarke, PG; Hirt, L; Repici, M; Schorderet, DF; Vercelli, A | 1 |
| Kim, H; Kim, SY; Kim, YS; Lee, J; Lee, P; Son, D | 1 |
| Abraini, JH; Buisson, A; Chazalviel, L; David, HN; Lemaire, M; Leveille, F; MacKenzie, ET | 1 |
| Janardhan, V; Qureshi, AI | 1 |
| Bachoo, R; Choi, YS; Gwag, BJ; Hong, SB; Jeon, HK; Jo, SY; Kang, HJ; Kim, EJ; Kim, KW; Kim, TK; Lee, HW; Reynolds, IJ; Won, SJ; Woo, RS | 1 |
| Benarese, M; Boroni, F; Dreano, M; Garotta, G; Pizzi, M; Sarnico, I; Spano, P; Valerio, A | 1 |
| Barber, PA; Buchan, AM; Hill, MD; Hoyte, L | 1 |
| Arundine, M; Tymianski, M | 1 |
| Iwashita, A; Jones, PA; May, GR; McLuckie, JA; Sharkey, J | 1 |
| Kim, YH; Koh, JY; Yi, JS | 1 |
| Chad, JE; McManus, T; Pringle, AK; Sadgrove, M; Sundstrom, LE | 1 |
| Cheng, T; Fernández, JA; Griffin, JH; Guo, H; Liu, D; Song, X; Zlokovic, BV | 1 |
| Ali, C; Benchenane, K; Buisson, A; Fernández-Monreal, M; Léveillé, F; Liot, G; López-Atalaya, JP; Mackenzie, ET; Ruocco, A; Vivien, D | 1 |
| Akaike, A; Fujimoto, S; Katsuki, H; Kume, T; Shinohara, A | 1 |
| Andreasson, K; Breyer, R; Liu, D; Mattson, MP; Wu, L | 1 |
| Miao, B; Yin, XH; Zhang, GY; Zhang, QG | 1 |
| Ampo, K; Kadono, C; Kiryu-Seo, S; Kiyama, H; Konishi, H; Maeda, M; Ohba, N | 1 |
| Beart, PM; Farso, M; Howells, DW; Liberatore, GT; Medcalf, RL; Moldrich, RX; Petersen, KU; Reddrop, C; Schleuning, WD | 1 |
| Brunette, E; Comas, T; Gendron, TF; Mealing, G; Monette, R; Morley, P; O'Reilly, N; Tauskela, JS | 1 |
| Kambe, Y; Nakamichi, N; Oikawa, H; Yoneda, Y | 1 |
| Ali, C; Fernandez-Monreal, M; Lebeurrier, N; Liot, G; Lopez-Atalaya, JP; Orset, C; Sonderegger, P; Vivien, D | 1 |
| Baik, EJ; Jung, YS; Kim, SU; Lee, BK; Lee, S; Lee, SH; Moon, CH; Park, HS; Park, S; Yi, KY; Yoo, SE | 1 |
| Cheng, XR; Du, GH; Sun, L | 1 |
| Boutin, H; Pinteaux, E; Rothwell, NJ | 1 |
| Bari, F; Busija, DW; Domoki, F; Guidetti, P; Nagy, K; Schwarcz, R | 1 |
| Anrather, J; Cho, S; Frys, KA; Iadecola, C; Kawano, T; Kunz, A; Orio, M; Park, L; Wang, G; Zhou, P | 1 |
| Fan, Y; Gu, Y; Lu, CZ; Qiao, J; Shi, L; Wang, Y; Xie, J; Yang, GY; Zhao, Y | 1 |
| Brunette, E; Hewitt, M; Kiedrowski, L; Lortie, K; Morley, P; Tauskela, JS | 1 |
| Ahn, YM; Byun, HY; Cho, JY; Cho, SI; Chung, JM; Gwag, BJ; Im, DS; Kim, KW; Ko, SY; Kwon, HJ; Lee, HU; Lee, JY; Lee, MJ; Lee, YA; Lim, HR; Moon, HS; Noh, JH; Park, SM; Son, SJ; Won, SJ; Yoon, SH; Yun, BS | 1 |
| Pignataro, G; Simon, RP; Xiong, ZG | 1 |
| Cheng, R; Li, S; Lin, YZ; Ma, H; Song, GR; Sun, CK; Xiao, XW; Xiao, ZY | 1 |
| Kirkeby, A; Leist, M; Montero, M; Noraberg, J; Poulsen, FR; van Beek, J; Zimmer, J | 1 |
| Li, C; Xu, J; Zhang, GY; Zhang, QG | 1 |
| Dos Santos, CD; Gomes-Leal, W; Picanço-Diniz, CW | 1 |
| Anthony, DC; Blamire, AM; Lowe, JP; Martin, MJ; Obrenovitch, TP; Sibson, NR | 1 |
| Attwell, D; Bakiri, Y; Hamilton, NB; Káradóttir, R | 1 |
| Cui, H; Lau, AC; Tymianski, M | 1 |
| Hartmann, J; Hildmann, O; Hillert, M; Kiewert, C; Klein, J; Kumar, V | 1 |
| Brines, M; Cerami, A; Divoux, D; Ghezzi, P; Mengozzi, M; Petit, E; Probert, L; Quackenbush, J; Roberts, ML; Taoufik, E; Tseveleki, V; Valable, S | 1 |
| Chacon, MR; Jensen, MB; Sattin, JA; Zivin, JA | 1 |
| Benavides, J; Dubois, A; Scatton, B | 1 |
| Cai, Z; Hersey, K; Rhodes, PG; Sigrest, T | 1 |
| Belayev, L; Busto, R; Ginsberg, MD; Zhao, W | 1 |
| Eybalin, M; Ladrech, S; Puel, JL; Pujol, R; Tribillac, F | 1 |
| Albert, A; Bonhomme, V; Collette, J; Hans, P; Moonen, G | 1 |
| Kawai, N; Masuzawa, T; Oguro, K; Robinson, HP; Tsubokawa, H | 1 |
| Vornov, JJ | 1 |
| Hamberg, L; Jiang, H; Lo, EH; Matsumoto, K; Pan, Y | 1 |
| Fiskum, G; Hurt, KJ; Rosenthal, RE; Werling, LL | 1 |
| Kanthan, R; Shuaib, A; Waqar, T; Wishart, T | 1 |
| Hakim, AM; Hogan, MJ; Takizawa, S | 1 |
| Giffard, RG; Maier, CM; Pérez-Pinzón, MA; Steinberg, GK; Sun, GH; Yoon, EJ | 1 |
| Davolio, C; Greenamyre, JT | 1 |
| Yoneda, Y | 1 |
| Grant, GA; Kunis, DM; Maier, CM; Steinberg, GK; Sun, GH; Yoon, EJ | 1 |
| Domańska-Janik, K; Lazarewicz, JW; Lukasiuk, K; Zabłocka, B | 1 |
| Benicourt, C; Junien, JL; Lockhart, BP; Privat, A; Soulard, P | 1 |
| Gaspary, HL; Graham, SH; Simon, RP | 1 |
| Akaike, N; Himori, N; Imai, M; Kurasawa, M; Matsukura, T; Mishima, K; Tanaka, Y; Ueno, K; Watanabe, H | 1 |
| Elben, U; Grome, JJ; Lee, GE; Lee, TB; Martin, LL; Paulus, E; Porsche-Wiebking, E; Rudolphi, KA; Rush, DK; Wilmot, CA | 1 |
| Lazarewicz, JW; Salińska, E | 1 |
| Bickler, PE; Buck, LT; Hansen, BM | 1 |
| Inoue, O; Nishizawa, K; Saito, Y; Suzuki, A | 1 |
| Katsuta, K; Koide, T; Nakanishi, H; Shirakawa, K; Ueda, Y; Yoshida, K | 1 |
| Ijaz, S; McCrea, S; Shuaib, A; Wishart, T | 1 |
| Burtrum, D; Silverstein, FS | 1 |
| Kuang, P; Xiang, J | 1 |
| Blanck, TJ; Fiskum, G; Fox, LG; Hoehner, PJ; Hurt, KJ; Rosenthal, RE; Werling, LL | 1 |
| Johnston, MV; McDonald, JW | 1 |
| Chen, J; Graham, SH; Simon, RP | 1 |
| Becker, CM; Gass, P; Kiessling, M; Muelhardt, C; Sommer, C | 1 |
| Buchan, A; Pulsinelli, W; Sarokin, A | 1 |
| Johnston, MV; Taylor, GA; Traystman, RJ; Trescher, WA | 1 |
| Ginsberg, MD | 1 |
| Bednar, DL; Borosky, SA; Ferkany, JW; Hamilton, GS; Huang, Z; Jones, BE; Karbon, EW; Patch, RJ; Willetts, J; Zubrowski, R | 1 |
| Beal, MF; Finklestein, SP; Nozaki, K | 1 |
| Fiskum, G; Jacocks, HM; Rosenthal, RE; Werling, LL | 1 |
| Heary, RF; Krieger, AJ; Maniker, AH; Sapru, HN | 1 |
| Ericson, H; Golanov, E; Inturrisi, CE; Reis, DJ; Wahlestedt, C; Yamamoto, S; Yee, F; Yoo, H | 1 |
| Chen, J; Graham, SH; Lan, JQ; Simon, RP | 1 |
| Cordi, AA; Desos, P; Lepagnol, JM; Lestage, P; Morain, P | 1 |
| Acarin, L; Castellano, B; Castro, AJ; González, B | 1 |
| Benz, AM; Clifford, DB; Izumi, Y; Zorumski, CF | 1 |
| Gill, R; van Lookeren Campagne, M | 1 |
| Dijkhuizen, RM; Nicolay, K; Niendorf, T; Norris, DG; van Lookeren Campagne, M | 1 |
| Bari, F; Busija, DW; Errico, RA; Louis, TM; McGough, PS; Meng, W; Tobin, JR | 1 |
| Ikonomidou, C; Turski, L | 1 |
| Buchan, AM; Small, DL | 1 |
| Block, F; Schwarz, M | 1 |
| Fujimura, Y; Inukai, T; Kometani, M; Nakao, K; Okada, M; Ueda, H | 1 |
| Ayata, C; Dalkara, T; Demirci, M; Erdemli, G; Onur, R | 1 |
| Akaike, N; Jin, YH; Koyama, S | 1 |
| Akaike, N; Ishibashi, H; Koyama, S; Murai, Y | 1 |
| Marini, AM; Mocchetti, I; Spiga, G | 1 |
| Fónagy, A; Latzkovits, L; Torday, C | 1 |
| Famularo, G; Panegrossi, A; Polchi, S; Sarazani, S | 1 |
| Almli, T; Chen, Q; Lukasiewicz, PD; Olney, JW; Romano, C | 1 |
| Durkin, JP; Mealing, GA; Morley, P; Murray, CL; Poulter, MO; Small, DL; Stanimirovic, DB | 1 |
| Bernardi, G; Calabresi, P; Centonze, D; Gubellini, P; Marfia, GA; Pisani, A; Sancesario, G | 1 |
| Chandler, LJ; Crews, FT; Day, A; Steck, JC; Yu, CJ | 1 |
| Airaksinen, MS; Gray, PA; Klapstein, GJ; Lieberman, DN; Meyer, M; Mody, I; Thoenen, H; Vietla, S | 1 |
| Barnewolt, CE; Dunning, PS; Taylor, GA | 1 |
| Choi, DW; Grabb, MC | 1 |
| de Graaf, RA; Dijkhuizen, RM; Nicolay, K; Tulleken, KA | 1 |
| Hartmann, A; Mohr, JP | 1 |
| Hayase, Y; Higashiyama, S; Ohno, M; Sasahara, M; Shimada, M; Tanaka, N | 1 |
| Bullock, R; Reinert, MM | 1 |
| Kim, DC; Todd, MM | 1 |
| Hicks, CA; Isaac, D; O'Neill, MJ; Osborne, DJ; Stamford, JA; Ward, MA | 1 |
| Iannotti, F; Pringle, AK; Signorelli, F; Thomas, SJ | 1 |
| Bari, F; Busija, DW; Domoki, F; Perciaccante, JV; Veltkamp, R | 1 |
| Alkayed, NJ; Blackshaw, S; Doré, S; Gallagher, M; Goto, S; Guastella, D; Hurn, PD; Koehler, RC; Sampei, K; Snyder, SH; Traystman, RJ | 1 |
| Fridman, O | 1 |
| Belayev, L; Busto, R; Ginsberg, MD; Liu, Y; Zhao, W | 1 |
| Gähwiler, BH; Gerber, U; Jabaudon, D; Scanziani, M | 1 |
| Armstead, WM | 1 |
| Boldyrev, A; Bulygina, E; Gallant, S; Kukley, M; Stvolinsky, S | 1 |
| Barbieri, I; Basudev, H; Brusa, R; Casati, C; Grilli, M; Lozza, G; Ongini, E | 1 |
| Fisher, M; Schaebitz, W | 1 |
| Blaabjerg, M; Bonde, C; Johansen, TE; Kristensen, BW; Meyer, M; Zimmer, J | 1 |
| Ali, C; Buisson, A; Fontaine, M; Ischenko, A; MacKenzie, ET; Nicole, O; van Beek, J | 1 |
| Anderson, TR; Andrew, RD; Jarvis, CR | 1 |
| Ali, C; Buisson, A; Docagne, F; MacKenzie, ET; Nicole, O; Plawinski, L; Vivien, D | 1 |
| Anthony, DC; Iannotti, F; Johns, P; Niyadurupola, N; Pringle, AK | 1 |
| Iannotti, F; Pringle, AK; Self, J | 1 |
| Hanon, E; Klitgaard, H | 1 |
| Comas, T; Hewitt, K; Hogan, M; Monette, R; Morley, P; Paris, J; Tauskela, JS | 1 |
| Iadecola, C; Kazama, K; Niwa, K; Ross, ME; Sugimoto, K | 1 |
| Butcher, SP; Macleod, MR | 1 |
| Chang, CF; Chiang, YH; Hoffer, J; Morales, M; Wang, Y | 1 |
| Buchan, AM | 2 |
| Benveniste, H; Hedlund, LW; Johnson, GA | 1 |
| Arvin, B; Lekieffre, D; Meldrum, B; Moncada, C | 1 |
| Albers, GW; Moses, JA; Sáenz, RE | 1 |
| Albers, GW; Choi, DW; Goldberg, MP | 2 |
| Beal, MF; Nozaki, K | 1 |
| Albrecht, RF; Hoffman, WE; Kochs, E; Pelligrino, D; Schulte am Esch, J; Werner, C | 1 |
| Backhauss, C; Karkoutly, C; Krieglstein, J; Welsch, M | 1 |
| Aquila, WJ; Petroff, OA; Yates, J; Young, RS | 1 |
| Itakura, T; Komai, N; Naka, Y; Nakai, K; Okuno, T; Ueno, M; Yokote, H | 1 |
| Clark, WM; Kochhar, A; Madden, KP; Zivin, JA | 1 |
| Gjedde, A; Hakim, AM; Hogan, MJ | 1 |
| Bonvento, G; Lazzaro, A; Lipartiti, M; Mazzari, S; Zanoni, R | 1 |
| Backhauss, C; Karkoutly, C; Krieglstein, J; Nuglisch, J; Peruche, B; Prehn, JH; Rossberg, C | 1 |
| Hakim, AM; Hogan, M; Takizawa, S | 1 |
| Bullock, R; Chen, M; Frey, P; Graham, DI; Lowe, D; McCulloch, J | 1 |
| Bommarito, M; Johnston, MV; McDonald, JW; Silverstein, FS | 1 |
| Albers, GW | 1 |
| Birch, PJ; Hayes, AG; Rogers, H | 1 |
| Choi, DW | 1 |
| Crain, BJ; Nadler, JV; Neill, KH; Somjen, GG; Urban, L | 1 |
| Hansen, AJ; Honoré, T; Jacobsen, P; Nielsen, EO; Sheardown, MJ | 1 |
| Meldrum, BS; Swan, JH | 1 |
| Diemer, NH; Johansen, FF; Jørgensen, MB | 1 |
| Boxer, PA; Cordon, JJ; Mann, ME; Marcoux, FW; Rock, DM; Rodolosi, LC; Taylor, CP; Vartanian, MG | 1 |
| Chernack, J; Cornfeldt, ML; Fielding, S; Martin, LL; Payack, JF; Ramirez, V; Rudolphi, KA; Rush, DK; Wilker, JC; Wilmot, CA | 1 |
| Bengtsson, F; Siesjö, BK | 1 |
| Choi, DW; Collins, RC; Dobkin, BH | 1 |
| Borosky, S; Ellenberger, SR; Ferkany, JW; Guzewska, ME; Jones, SM; Kyle, DJ; Rzeszotarski, WJ; Sacaan, AI; Snell, LD; Willets, J | 1 |
| Araki, T; Kogure, K; Onodera, H | 1 |
| Ikonomidou, C; Labruyere, J; Mosinger, JL; Olney, JW; Salles, KS | 1 |
| McCulloch, J; Nehls, DG; Park, CK; Teasdale, GM | 1 |
| Arbilla, S; Benavides, J; Carter, C; Legendre, P; Lloyd, KG; MacKenzie, ET; Noel, F; Thuret, F; Vincent, JD; Zivkovic, B | 1 |
| Bertin, J; Carter, C; Dupont, R; Duverger, D; Frost, J; Gaudilliere, B; Gotti, B; MacKenzie, ET; Rousseau, J; Scatton, B | 1 |
| Meldrum, B; Schwarcz, R | 1 |
| Graham, DI; McCulloch, J; Nehls, DG; Park, CK; Teasdale, GM | 1 |
| Arcavi, LJ; Ferriero, DM; McIntosh, TK; Sagar, SM; Simon, RP | 1 |
| Bowery, NG; Hudson, AL; Wong, EH | 1 |
| Kunis, D; Saleh, J; Steinberg, GK | 1 |
29 review(s) available for n-methylaspartate and Brain Ischemia
| Article | Year |
|---|---|
[Functional roles of constitutively active calcineurin in delayed neuronal death after brain ischemia].
Topics: Active Transport, Cell Nucleus; Animals; Brain Ischemia; Calcineurin; Calcium; Calcium Channels; Calpain; Cell Death; Cell Nucleus; Disease Models, Animal; Fas Ligand Protein; Forkhead Box Protein O1; Forkhead Transcription Factors; Mice; N-Methylaspartate; Neurons; NFATC Transcription Factors; Protein Binding; Up-Regulation | 2011 |
A role for tumor necrosis factor-α in ischemia and ischemic preconditioning.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain; Brain Ischemia; Glutamic Acid; Humans; Ischemic Preconditioning; N-Methylaspartate; Neurons; Receptors, Tumor Necrosis Factor; Signal Transduction; Tumor Necrosis Factor-alpha | 2011 |
Involvement of nitric oxide in ischemia-evoked taurine release in the mouse hippocampus.
Topics: Animals; Brain Ischemia; Cyclic GMP; Hippocampus; Mice; N-Methylaspartate; Nitric Oxide; Nitric Oxide Donors; Taurine | 2003 |
Mechanisms of ischemic brain injury.
Topics: Apoptosis; Brain Ischemia; Ferrous Compounds; Homeostasis; Humans; Hyperbaric Oxygenation; N-Methylaspartate; Oxygen Consumption; Platelet Glycoprotein GPIIb-IIIa Complex; Regional Blood Flow; Reperfusion; Thrombolytic Therapy | 2004 |
The rise and fall of NMDA antagonists for ischemic stroke.
Topics: Animals; Brain Ischemia; Cell Survival; Disease Models, Animal; Excitatory Amino Acid Antagonists; Guanidines; Humans; Indoles; Ischemia; N-Methylaspartate; Neurons; Pipecolic Acids; Receptors, N-Methyl-D-Aspartate; Stroke | 2004 |
Molecular mechanisms of glutamate-dependent neurodegeneration in ischemia and traumatic brain injury.
Topics: Animals; Brain Injuries; Brain Ischemia; Glutamic Acid; Humans; N-Methylaspartate; Nerve Degeneration; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate | 2004 |
Relevant modulation by ferrous ions of N-methyl-D-aspartate receptors in ischemic brain injuries.
Topics: Animals; Brain; Brain Ischemia; Chlorides; Dose-Response Relationship, Drug; Drug Interactions; Ferric Compounds; Ferrous Compounds; Humans; Ion Channels; Models, Biological; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate | 2004 |
[Advances in vulnerable mechanisms of selectively vulnerable neurons].
Topics: Alzheimer Disease; Animals; Brain; Brain Ischemia; Hippocampus; Humans; N-Methylaspartate; Neurons | 2005 |
The use of propidium iodide to assess excitotoxic neuronal death in primary mixed cortical cultures.
Topics: Acute Disease; Animals; Benzimidazoles; Brain Ischemia; Cell Death; Cells, Cultured; Cerebral Cortex; Drug Evaluation, Preclinical; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Humans; Immunohistochemistry; Indicators and Reagents; Mice; Microscopy, Fluorescence; N-Methylaspartate; Neurodegenerative Diseases; Neurons; Neuroprotective Agents; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type I; Propidium; Receptors, N-Methyl-D-Aspartate | 2007 |
Neuroprotection in cerebral ischemia: emphasis on the SAINT trial.
Topics: Acute Disease; Benzenesulfonates; Brain Ischemia; Cardiovascular Agents; Clinical Trials as Topic; GABA Agonists; Humans; Hypothermia; N-Methylaspartate; Narcotic Antagonists; Neuroprotective Agents; Stroke; Tissue Plasminogen Activator | 2008 |
[Receptive mechanisms of excitatory amino acid signals].
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Brain Ischemia; Epilepsy; Ibotenic Acid; Kainic Acid; Ligands; N-Methylaspartate; Receptors, Amino Acid; Signal Transduction; Transcription Factors | 1993 |
Excitatory amino acid neurotoxicity in the developing brain.
Topics: Animals; Brain; Brain Ischemia; Dizocilpine Maleate; Humans; Kainic Acid; N-Methylaspartate; Quisqualic Acid; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate | 1993 |
Emerging strategies for the treatment of ischemic brain injury.
Topics: Animals; Benzazepines; Body Temperature; Brain; Brain Injuries; Brain Ischemia; Calcium Channel Blockers; Dextromethorphan; Dizocilpine Maleate; Drug Therapy, Combination; Humans; Ischemic Attack, Transient; N-Methylaspartate | 1993 |
Neurodegenerative disorders: clues from glutamate and energy metabolism.
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Damage, Chronic; Brain Injuries; Brain Ischemia; Energy Metabolism; Excitatory Amino Acid Antagonists; Glutamates; Humans; N-Methylaspartate; Nerve Degeneration; Nervous System Diseases; Neurotoxins | 1996 |
NMDA antagonists: their role in neuroprotection.
Topics: Animals; Brain Ischemia; Cells, Cultured; Disease Models, Animal; Humans; N-Methylaspartate; Neurons; Neuroprotective Agents; Receptors, N-Methyl-D-Aspartate | 1997 |
Toward the development of strategies to prevent ischemic neuronal injury. In vitro studies.
Topics: Animals; Apoptosis; Brain Ischemia; Cell Death; Cerebellum; Fibroblast Growth Factor 2; Glutamic Acid; N-Methylaspartate; Neurons; Neuroprotective Agents; Neurotoxins; Receptors, N-Methyl-D-Aspartate; Transcription, Genetic | 1997 |
[Ischemic stroke. What approach in the Emergency Department?].
Topics: Acetylcarnitine; Acute Disease; Brain Ischemia; Calcium Channel Blockers; Cerebrovascular Circulation; Clinical Trials as Topic; Electrocardiography; Emergency Service, Hospital; Excitatory Amino Acid Antagonists; Humans; Meta-Analysis as Topic; Multicenter Studies as Topic; N-Methylaspartate; Nootropic Agents; Thrombolytic Therapy; Tomography, X-Ray Computed | 1997 |
Clinical trials in head injury.
Topics: Arachidonic Acid; Barbiturates; Brain; Brain Ischemia; Calcium Channel Blockers; Clinical Trials as Topic; Craniocerebral Trauma; Free Radical Scavengers; Humans; Hypothermia, Induced; Injury Severity Score; N-Methylaspartate; Potassium Channel Blockers; Sodium Channel Blockers; Steroids | 1999 |
[Hyperhomocysteinemia: atherothrombosis and neurotoxicity].
Topics: Brain Ischemia; Homocysteine; Humans; Hyperhomocysteinemia; N-Methylaspartate; Nitric Oxide; Nitric Oxide Synthase; Receptors, N-Methyl-D-Aspartate; Risk Factors; Thrombosis; Vascular Diseases | 1999 |
An overview of acute stroke therapy: past, present, and future.
Topics: Acute Disease; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Antibodies; Brain Ischemia; Calcium Channel Blockers; Cardiovascular Agents; Cell Adhesion Molecules; Clinical Trials as Topic; Cytidine Diphosphate Choline; Cytokines; Drug Therapy, Combination; Fibrinolytic Agents; Free Radical Scavengers; gamma-Aminobutyric Acid; Growth Substances; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; N-Methylaspartate; Neuroprotective Agents; Nootropic Agents; Piperidines; Stroke; Thiazoles; Thrombolytic Therapy | 2000 |
Protective effects of glial cell line-derived neurotrophic factor in ischemic brain injury.
Topics: Animals; Apoptosis; Brain; Brain Ischemia; Calcitriol; Drosophila Proteins; Fetal Tissue Transplantation; Glial Cell Line-Derived Neurotrophic Factor; Glial Cell Line-Derived Neurotrophic Factor Receptors; Humans; Infarction, Middle Cerebral Artery; N-Methylaspartate; Nerve Growth Factors; Nerve Tissue Proteins; Neurons; Neuroprotective Agents; Nitric Oxide; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ret; Receptor Protein-Tyrosine Kinases | 2002 |
Do NMDA antagonists prevent neuronal injury? No.
Topics: Animals; Brain; Brain Diseases; Brain Ischemia; Cell Death; Glutamates; Glutamic Acid; Hypoxia, Brain; N-Methylaspartate; Neurons; Receptors, N-Methyl-D-Aspartate | 1992 |
Do NMDA antagonists prevent neuronal injury? Yes.
Topics: Animals; Brain; Brain Diseases; Brain Ischemia; Cell Death; Hypoxia, Brain; N-Methylaspartate; Neurons | 1992 |
Potential therapeutic uses of N-methyl-D-aspartate antagonists in cerebral ischemia.
Topics: Aspartic Acid; Brain Ischemia; Glutamates; Glutamic Acid; Humans; Models, Biological; N-Methylaspartate; Nervous System; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
Do NMDA antagonists protect against cerebral ischemia: are clinical trials warranted?
Topics: Animals; Brain Ischemia; Clinical Trials as Topic; Humans; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate | 1990 |
Possible mechanisms limiting N-methyl-D-aspartate receptor overactivation and the therapeutic efficacy of N-methyl-D-aspartate antagonists.
Topics: Adenosine; Animals; Brain Ischemia; Calcium; Glutamates; Hydrogen-Ion Concentration; Hypoxia; N-Methylaspartate; Rats; Receptors, N-Methyl-D-Aspartate; Zinc | 1990 |
Calcium fluxes, calcium antagonists, and calcium-related pathology in brain ischemia, hypoglycemia, and spreading depression: a unifying hypothesis.
Topics: Aspartic Acid; Biological Transport, Active; Brain; Brain Ischemia; Calcium; Calcium Channels; Cell Membrane; Cell Survival; Glutamates; Homeostasis; Humans; Hypoglycemia; N-Methylaspartate; Neurons; Potassium; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
Selective vulnerability of the brain: new insights into the pathophysiology of stroke.
Topics: Animals; Aspartic Acid; Brain; Brain Ischemia; Cell Survival; Glutamates; Humans; N-Methylaspartate; Neurons; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synaptic Transmission | 1989 |
N-methyl-D-aspartate antagonists: ready for clinical trial in brain ischemia?
Topics: Aspartic Acid; Brain; Brain Ischemia; Clinical Trials as Topic; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Humans; Models, Neurological; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synapses; Synaptic Transmission | 1989 |
2 trial(s) available for n-methylaspartate and Brain Ischemia
| Article | Year |
|---|---|
Tolerability of oral dextromethorphan in patients with a history of brain ischemia.
Topics: Aged; Brain Ischemia; Dextromethorphan; Female; Humans; Male; Middle Aged; N-Methylaspartate; Psychiatric Status Rating Scales | 1992 |
N-methyl-D-aspartate antagonists: ready for clinical trial in brain ischemia?
Topics: Aspartic Acid; Brain; Brain Ischemia; Clinical Trials as Topic; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Humans; Models, Neurological; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synapses; Synaptic Transmission | 1989 |
198 other study(ies) available for n-methylaspartate and Brain Ischemia
| Article | Year |
|---|---|
Lithium upregulates growth-associated protein-43 (GAP-43) and postsynaptic density-95 (PSD-95) in cultured neurons exposed to oxygen-glucose deprivation and improves electrophysiological outcomes in rats subjected to transient focal cerebral ischemia foll
Topics: Animals; Brain Ischemia; Brain-Derived Neurotrophic Factor; Disks Large Homolog 4 Protein; Edetic Acid; GAP-43 Protein; Glucose; Glycogen Synthase Kinase 3 beta; Infarction, Middle Cerebral Artery; Lithium; Lithium Chloride; Male; N-Methylaspartate; Neurons; Neuroprotective Agents; Oxygen; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sodium Dodecyl Sulfate | 2022 |
Discovery of novel tryptamine derivatives as GluN2B subunit-containing NMDA receptor antagonists via pharmacophore-merging strategy with orally available therapeutic effect of cerebral ischemia.
Topics: Animals; Brain Ischemia; Humans; Mice; N-Methylaspartate; Pharmacophore; Receptors, N-Methyl-D-Aspartate; Tryptamines | 2023 |
Furin-mediated cleavage of LRP1 and increase in ICD of LRP1 after cerebral ischemia and after exposure of cultured neurons to NMDA.
Topics: Animals; Brain Ischemia; Disease Models, Animal; Endocytosis; Furin; Humans; Low Density Lipoprotein Receptor-Related Protein-1; N-Methylaspartate; Neurodegenerative Diseases; Neurons; Rats; Receptors, LDL; Signal Transduction; Stroke; trans-Golgi Network | 2019 |
A novel cell-penetrating peptide targeting calpain-cleavage of PSD-95 induced by excitotoxicity improves neurological outcome after stroke.
Topics: Animals; Brain Ischemia; Calpain; Cell Survival; Cell-Penetrating Peptides; Cells, Cultured; Disease Models, Animal; Disks Large Homolog 4 Protein; Down-Regulation; Excitatory Amino Acid Agonists; HEK293 Cells; Humans; Male; Mice; Mice, Inbred BALB C; Movement Disorders; N-Methylaspartate; Neurons; Neuroprotection; Stroke | 2021 |
The physiological role of Homer2a and its novel short isoform, Homer2e, in NMDA receptor-mediated apoptosis in cerebellar granule cells.
Topics: Amino Acid Sequence; Animals; Apoptosis; Base Sequence; Brain Ischemia; Cerebellum; Homer Scaffolding Proteins; Mice, Inbred ICR; Models, Biological; N-Methylaspartate; Protein Domains; Protein Isoforms; Receptors, N-Methyl-D-Aspartate | 2021 |
The Neuronal Ischemic Tolerance Is Conditioned by the Tp53 Arg72Pro Polymorphism.
Topics: Aged; Aged, 80 and over; Animals; Apoptosis; Arginine; Brain Ischemia; Caspase 3; Cell Hypoxia; Cells, Cultured; Cerebral Cortex; Cohort Studies; Electron Transport Complex IV; Embryo, Mammalian; Excitatory Amino Acid Agonists; Female; Glucose; Humans; Ischemic Preconditioning; Male; Membrane Potentials; Mice; Microtubule-Associated Proteins; Middle Aged; N-Methylaspartate; Neurons; Polymorphism, Single Nucleotide; Proline; Subcellular Fractions; Tumor Suppressor Protein p53 | 2019 |
SPARC regulates microgliosis and functional recovery following cortical ischemia.
Topics: Age Factors; Animals; Animals, Newborn; Brain Infarction; Brain Ischemia; Calcium-Binding Proteins; Cell Count; Cell Movement; Cell Proliferation; Cell Size; Cells, Cultured; Cerebral Cortex; CX3C Chemokine Receptor 1; Disease Models, Animal; Excitatory Amino Acid Agonists; Female; Forelimb; Galectin 3; Gene Expression Regulation, Developmental; Genotype; Glial Fibrillary Acidic Protein; Gliosis; Glycoproteins; Green Fluorescent Proteins; Intracranial Thrombosis; Lectins; Male; Mice; Mice, Transgenic; Microfilament Proteins; Microglia; Motor Skills; Mutation; N-Methylaspartate; NF-kappaB-Inducing Kinase; Olfactory Bulb; Osteonectin; Proliferating Cell Nuclear Antigen; Protein Serine-Threonine Kinases; Receptors, Chemokine; Recovery of Function; Time Factors; Tumor Suppressor Proteins | 2013 |
Critical role of increased PTEN nuclear translocation in excitotoxic and ischemic neuronal injuries.
Topics: Animals; Brain; Brain Ischemia; Cells, Cultured; Disease Models, Animal; Embryo, Mammalian; Excitatory Amino Acid Agonists; Female; Fluorodeoxyglucose F18; Green Fluorescent Proteins; L-Lactate Dehydrogenase; Male; Mice; Mutation; N-Methylaspartate; Nervous System Diseases; Neurons; Nuclear Localization Signals; Peptides; Pregnancy; Protein Transport; PTEN Phosphohydrolase; Radionuclide Imaging; Rats; Rats, Sprague-Dawley | 2013 |
The nuclear calcium signaling target, activating transcription factor 3 (ATF3), protects against dendrotoxicity and facilitates the recovery of synaptic transmission after an excitotoxic insult.
Topics: Activating Transcription Factor 3; Animals; Brain Ischemia; Calcium Signaling; Cell Death; Dendrites; Excitatory Amino Acid Agonists; Gene Expression Regulation; Gene Knockdown Techniques; Hippocampus; Mice; N-Methylaspartate; Nerve Net; Nerve Tissue Proteins; Synaptic Transmission; Transcription, Genetic | 2014 |
Differential neuroprotective effects of 5'-deoxy-5'-methylthioadenosine.
Topics: Acute Disease; Adrenergic Antagonists; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Blood-Brain Barrier; Brain Ischemia; Cell Membrane Permeability; Cells, Cultured; Chronic Disease; Deoxyadenosines; Disease Models, Animal; Glucose; Male; Mice; N-Methylaspartate; Nerve Degeneration; Neuroprotective Agents; Neurotoxins; Oxygen; Pilocarpine; Rats; Rats, Sprague-Dawley; Rats, Wistar; Status Epilepticus; Thionucleosides | 2014 |
Neuroprotective effects of daphnetin against NMDA receptor-mediated excitotoxicity.
Topics: Animals; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Brain Ischemia; Cerebral Cortex; Gene Expression Regulation; Glutamic Acid; Humans; Mice; N-Methylaspartate; Neurons; Neuroprotective Agents; Primary Cell Culture; Proto-Oncogene Proteins c-bcl-2; Receptors, N-Methyl-D-Aspartate; Umbelliferones | 2014 |
BQ-869, a novel NMDA receptor antagonist, protects against excitotoxicity and attenuates cerebral ischemic injury in stroke.
Topics: Animals; Brain Ischemia; Cell Death; Cells, Cultured; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Heterocyclic Compounds, 4 or More Rings; Hippocampus; N-Methylaspartate; Neuroprotective Agents; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Stroke | 2015 |
Neuroprotective effects of a novel translocator protein (18 kDa) ligand, ZBD-2, against focal cerebral ischemia and NMDA-induced neurotoxicity.
Topics: Acetamides; Animals; Apoptosis; bcl-2-Associated X Protein; Brain; Brain Ischemia; Caspase 3; Female; Gene Expression Regulation; Ligands; Male; Mice; N-Methylaspartate; Neurons; Neuroprotective Agents; Proto-Oncogene Proteins c-bcl-2; Purinones; Receptors, GABA; Receptors, N-Methyl-D-Aspartate | 2015 |
Naturally occurring marine steroid 24-methylenecholestane-3β,5α,6β,19-tetraol functions as a novel neuroprotectant.
Topics: Animals; Aquatic Organisms; Brain Ischemia; Cerebral Cortex; Cholestanols; Glutamic Acid; Infarction, Middle Cerebral Artery; Magnetic Resonance Spectroscopy; Male; Mice; N-Methylaspartate; Neurons; Neuroprotective Agents; Rats, Sprague-Dawley | 2016 |
Proton-gated Ca(2+)-permeable TRP channels damage myelin in conditions mimicking ischaemia.
Topics: Animals; Brain Ischemia; Calcium; Calcium Signaling; Electric Conductivity; Female; Hydrogen-Ion Concentration; Magnesium; Male; Mice; Mice, Transgenic; Multiple Sclerosis; Myelin Sheath; N-Methylaspartate; Oligodendroglia; Potassium; Protons; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Stroke; Transient Receptor Potential Channels; White Matter | 2016 |
Bryonolic Acid, a Triterpenoid, Protect Against N-methyl-d-Aspartate-Induced Neurotoxicity in PC12 Cells.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Brain Ischemia; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cell Survival; Cyclic AMP Response Element-Binding Protein; Gene Expression Regulation; Humans; N-Methylaspartate; Neuroprotective Agents; PC12 Cells; Proto-Oncogene Proteins c-bcl-2; Rats; Signal Transduction; Triterpenes | 2016 |
Clusterin increases post-ischemic damages in organotypic hippocampal slice cultures.
Topics: Animals; Brain Ischemia; Cell Hypoxia; Clusterin; Glucose; Hippocampus; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Organ Culture Techniques; Oxygen Consumption | 2008 |
Neuroprotection by nitrous oxide: facts and evidence.
Topics: Animals; Body Temperature; Brain; Brain Ischemia; Dopamine; Dose-Response Relationship, Drug; Glucose; In Vitro Techniques; Infarction, Middle Cerebral Artery; L-Lactate Dehydrogenase; Male; Motor Activity; N-Methylaspartate; Neuroprotective Agents; Nitrous Oxide; Oxygen; Rats; Rats, Sprague-Dawley | 2008 |
Increased tyrosine phosphorylation of PSD-95 by Src family kinases after brain ischaemia.
Topics: Animals; Binding Sites; Brain Ischemia; Cells, Cultured; Chlorocebus aethiops; COS Cells; Disks Large Homolog 4 Protein; Glutamic Acid; Hippocampus; Immunoblotting; Immunoprecipitation; Intracellular Signaling Peptides and Proteins; Male; Membrane Proteins; Mutation; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Phosphorylation; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; src-Family Kinases; Tyrosine | 2009 |
Effects of exogenous excitatory amino acid neurotransmitters on blood-brain barrier disruption in focal cerebral ischemia.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Aminoisobutyric Acids; Animals; Blood-Brain Barrier; Brain Ischemia; Cerebral Cortex; Infarction, Middle Cerebral Artery; Male; N-Methylaspartate; Rats; Rats, Wistar; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate | 2009 |
Glutamate, microdialysis, and cerebral ischemia: lost in translation?
Topics: Amino Acids; Animals; Brain Ischemia; gamma-Aminobutyric Acid; Glutamic Acid; Microdialysis; N-Methylaspartate; Rats; Receptors, N-Methyl-D-Aspartate | 2009 |
Differential susceptibility to excitotoxic stress in YAC128 mouse models of Huntington disease between initiation and progression of disease.
Topics: Animals; Brain; Brain Ischemia; Cells, Cultured; Dendritic Spines; Disease Models, Animal; Disease Progression; Genetic Predisposition to Disease; Huntington Disease; Mice; Mice, Transgenic; N-Methylaspartate; Nerve Degeneration; Neurotoxins; Organ Culture Techniques; Phenotype; Quinolinic Acid; Stress, Physiological; Synaptic Membranes; Synaptic Potentials; Synaptic Transmission | 2009 |
Ischaemia differentially regulates GABA(B) receptor subunits in organotypic hippocampal slice cultures.
Topics: Animals; Baclofen; Brain Ischemia; Cell Death; Cell Hypoxia; Drug Evaluation, Preclinical; GABA Agonists; GABA-B Receptor Agonists; Gene Expression Regulation; Glucose; Hippocampus; Male; N-Methylaspartate; Neuroprotective Agents; Neurotoxins; Organ Culture Techniques; Oxygen; Rats; Rats, Wistar; Receptors, GABA-B; RNA, Messenger | 2009 |
Excitotoxicity-induced endocytosis confers drug targeting in cerebral ischemia.
Topics: Alanine; Animals; Animals, Newborn; Brain Ischemia; Cells, Cultured; Cerebral Cortex; Dextrans; Disease Models, Animal; Dynamin I; Endocytosis; Excitatory Amino Acid Agonists; Fluorescein-5-isothiocyanate; Gene Products, tat; Green Fluorescent Proteins; Horseradish Peroxidase; Injections, Intraventricular; Lysine; Male; Mutation; N-Methylaspartate; Neurons; Rats; Rats, Sprague-Dawley; Transfection; Vesicular Transport Proteins | 2009 |
Expression and regulated nuclear transport of transducers of regulated CREB 1 in retinal ganglion cells.
Topics: Active Transport, Cell Nucleus; Animals; Brain Ischemia; Brain-Derived Neurotrophic Factor; Cell Nucleus; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Cytoplasm; Male; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reperfusion Injury; Retina; Retinal Ganglion Cells; RNA, Messenger; Trans-Activators; Transcription Factors | 2009 |
Unconjugated TAT carrier peptide protects against excitotoxicity.
Topics: Age Factors; Animals; Animals, Newborn; Brain Ischemia; Cell Death; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Kainic Acid; L-Lactate Dehydrogenase; N-Methylaspartate; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; tat Gene Products, Human Immunodeficiency Virus; Time Factors | 2009 |
PGF(2alpha) FP receptor contributes to brain damage following transient focal brain ischemia.
Topics: Analysis of Variance; Animals; Antihypertensive Agents; Brain Infarction; Brain Injuries; Brain Ischemia; Disease Models, Animal; Excitatory Amino Acid Agonists; Latanoprost; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Nervous System Diseases; Prostaglandins F, Synthetic; Receptors, Prostaglandin; Receptors, Prostaglandin E | 2009 |
Secretory phospholipase A2 inhibitor PX-18 preserves microvascular reactivity after cerebral ischemia in piglets.
Topics: Alkanesulfonic Acids; Animals; Animals, Newborn; Arterioles; Bradykinin; Brain Ischemia; Cerebral Arteries; Cerebrovascular Circulation; Chemistry, Pharmaceutical; Drug Evaluation, Preclinical; Enzyme Inhibitors; Hypercapnia; Microscopy, Video; N-Methylaspartate; Neurons; Oleic Acids; Particle Size; Phospholipases A2, Secretory; Pia Mater; Reperfusion Injury; Swine; Vasodilation; Vasodilator Agents | 2009 |
Age and albumin D site-binding protein control tissue plasminogen activator levels: neurotoxic impact.
Topics: Aged; Aged, 80 and over; Aging; Animals; Brain; Brain Ischemia; Cell Death; Disease Models, Animal; DNA-Binding Proteins; Female; Gene Knockdown Techniques; Humans; Magnetic Resonance Imaging; Mice; Mice, Inbred C57BL; Middle Aged; N-Methylaspartate; Neurons; Reverse Transcriptase Polymerase Chain Reaction; Tissue Plasminogen Activator; Transcription Factors | 2009 |
Ibuprofen for neuroprotection after cerebral ischemia.
Topics: Animals; Astrocytes; Brain Ischemia; Cell Death; Cells, Cultured; Excitatory Amino Acid Agonists; Ibuprofen; Kainic Acid; L-Lactate Dehydrogenase; Mice; N-Methylaspartate; Neuroprotective Agents | 2010 |
Caffeinol at the receptor level: anti-ischemic effect of N-methyl-D-aspartate receptor blockade is potentiated by caffeine.
Topics: Animals; Brain Ischemia; Caffeine; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Combinations; Drug Synergism; Ethanol; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Guanidines; Male; N-Methylaspartate; Nerve Degeneration; Neuroprotective Agents; Neurotoxins; Phosphodiesterase Inhibitors; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Time Factors; Treatment Outcome | 2010 |
Survival effect of PDGF-CC rescues neurons from apoptosis in both brain and retina by regulating GSK3beta phosphorylation.
Topics: Animals; Antibodies; Apoptosis; Apoptosis Regulatory Proteins; Brain; Brain Ischemia; Capillary Permeability; Cell Survival; Cerebral Cortex; Female; Gene Expression; Gene Expression Profiling; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Hydrogen Peroxide; Lymphokines; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Neovascularization, Pathologic; Nerve Growth Factors; Neurons; Optic Nerve Injuries; Parkinson Disease, Secondary; Phosphorylation; Platelet-Derived Growth Factor; Rats; Receptor, Platelet-Derived Growth Factor alpha; Receptor, Platelet-Derived Growth Factor beta; Retina; Retinal Ganglion Cells; Retinal Vessels; Stroke Volume; Substantia Nigra; Tyrosine 3-Monooxygenase | 2010 |
The DREAM protein negatively regulates the NMDA receptor through interaction with the NR1 subunit.
Topics: Analysis of Variance; Animals; Biotinylation; Brain Edema; Brain Infarction; Brain Ischemia; Cell Count; Cells, Cultured; CHO Cells; Cricetinae; Cricetulus; Disease Models, Animal; Dose-Response Relationship, Drug; Embryo, Mammalian; Excitatory Amino Acid Agonists; Gene Expression Regulation; Glucose; Green Fluorescent Proteins; Hippocampus; Humans; Hypoxia; Immunoprecipitation; Kv Channel-Interacting Proteins; L-Lactate Dehydrogenase; Membrane Potentials; Mice; Mice, Inbred BALB C; Mutation; N-Methylaspartate; Neurons; Neuroprotective Agents; Oocytes; Patch-Clamp Techniques; Peptides; Protein Binding; Protein Transport; Rats; Receptors, N-Methyl-D-Aspartate; Repressor Proteins; RNA, Small Interfering; Time Factors; Transfection; Xenopus | 2010 |
CPEB4 is a cell survival protein retained in the nucleus upon ischemia or endoplasmic reticulum calcium depletion.
Topics: Amino Acid Sequence; Animals; Brain Ischemia; Calcium; Cell Nucleus; Cells, Cultured; Endoplasmic Reticulum; Humans; Molecular Sequence Data; N-Methylaspartate; Neurons; Protein Isoforms; Rats; Receptors, Ionotropic Glutamate; Recombinant Fusion Proteins; RNA-Binding Proteins; Sodium Channel Blockers; Tetrodotoxin | 2010 |
Neuronal gap junctions are required for NMDA receptor-mediated excitotoxicity: implications in ischemic stroke.
Topics: Animals; Apoptosis; Blood-Brain Barrier; Brain Ischemia; Cells, Cultured; Connexins; Dentate Gyrus; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Gap Junction delta-2 Protein; Gap Junctions; Male; Mefloquine; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Nerve Degeneration; Neurons; Neurotoxins; Patch-Clamp Techniques; Photochemistry; Receptors, N-Methyl-D-Aspartate; Rose Bengal | 2010 |
KCa2 channels activation prevents [Ca2+]i deregulation and reduces neuronal death following glutamate toxicity and cerebral ischemia.
Topics: Animals; Brain Ischemia; Calcium Signaling; Cell Culture Techniques; Cell Death; Cells, Cultured; Excitatory Amino Acid Agonists; Glutamic Acid; Indoles; Infarction, Middle Cerebral Artery; Male; Mice; Mice, Inbred C57BL; N-Methylaspartate; Neurons; Neuroprotective Agents; Oximes; Small-Conductance Calcium-Activated Potassium Channels; Transcription, Genetic | 2011 |
Neuroprotection by NMDA preconditioning against glutamate cytotoxicity is mediated through activation of ERK 1/2, inactivation of JNK, and by prevention of glutamate-induced CREB inactivation.
Topics: Animals; Brain Ischemia; Cell Survival; Cyclic AMP Response Element-Binding Protein; Enzyme Activation; Excitatory Amino Acid Agonists; Glutamic Acid; Ischemic Preconditioning; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; N-Methylaspartate; Neurons; Neuroprotective Agents; Neurotoxins; Primary Cell Culture; Rats; Reperfusion Injury | 2012 |
Cerebroside-A provides potent neuroprotection after cerebral ischaemia through reducing glutamate release and Ca²⁺ influx of NMDA receptors.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Analysis of Variance; Animals; Brain Ischemia; Calcium; Cerebral Infarction; Cerebrosides; Charybdotoxin; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glucose; Glutamic Acid; Hippocampus; Hypoxia; In Vitro Techniques; Infarction, Middle Cerebral Artery; Long-Term Potentiation; Male; Mice; Mice, Inbred C57BL; N-Methylaspartate; Neuroprotective Agents; Neurotoxins; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Tetrazolium Salts; Valine | 2012 |
Glutamatergic neurons in rodent models respond to nanoscale particulate urban air pollutants in vivo and in vitro.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain Ischemia; Cells, Cultured; Cerebral Cortex; Glutamic Acid; Hippocampus; In Vitro Techniques; Inhalation Exposure; Interleukin-1alpha; Male; Mice; Mice, Inbred C57BL; N-Methylaspartate; Neuroglia; Neurons; Particulate Matter; Rats; Receptors, AMPA; RNA, Messenger; Tumor Necrosis Factor-alpha; Vehicle Emissions | 2011 |
SP-8203 shows neuroprotective effects and improves cognitive impairment in ischemic brain injury through NMDA receptor.
Topics: Acetamides; Animals; Animals, Newborn; Brain Injuries; Brain Ischemia; Cells, Cultured; Cognition Disorders; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred ICR; N-Methylaspartate; Neuroprotective Agents; Quinazolinones; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 2011 |
A3 adenosine receptor agonist reduces brain ischemic injury and inhibits inflammatory cell migration in rats.
Topics: Adenosine; Adenosine A3 Receptor Agonists; Animals; Brain Infarction; Brain Injuries; Brain Ischemia; Cell Movement; Chemokine CCL2; Glucose; Inflammation; Interleukin-1beta; Lipopolysaccharides; Male; Microglia; Monocytes; N-Methylaspartate; Protein Transport; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; rho GTP-Binding Proteins; Thionucleosides; Tumor Necrosis Factor-alpha | 2011 |
Validation of organotypical hippocampal slice cultures as an ex vivo model of brain ischemia: different roles of NMDA receptors in cell death signalling after exposure to NMDA or oxygen and glucose deprivation.
Topics: Animals; Blotting, Western; Brain Ischemia; Cattle; Cell Death; Chickens; Dizocilpine Maleate; Gene Expression Regulation; Glucose; Hydrogen-Ion Concentration; Models, Biological; N-Methylaspartate; Neurotoxins; Organ Culture Techniques; Oxygen; Protein Subunits; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Reproducibility of Results; RNA, Messenger; Signal Transduction | 2011 |
Ex vivo and in vivo neuroprotection induced by argon when given after an excitotoxic or ischemic insult.
Topics: Animals; Argon; Brain; Brain Injuries; Brain Ischemia; Disease Models, Animal; Dose-Response Relationship, Drug; Glucose; Infarction, Middle Cerebral Artery; Male; Models, Statistical; N-Methylaspartate; Neurons; Neuroprotective Agents; Oxygen; Rats; Rats, Sprague-Dawley; Synapses | 2012 |
Lymphocyte cell kinase activation mediates neuroprotection during ischemic preconditioning.
Topics: Adaptor Proteins, Signal Transducing; Animals; Brain Ischemia; Cell Death; Cerebral Cortex; Disease Models, Animal; Gene Silencing; Glucose; Ischemic Preconditioning; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Mice; Mice, Knockout; N-Methylaspartate; Neurons; Neuroprotective Agents; Oxygen; Primary Cell Culture; Protein Kinase C-epsilon; RNA, Small Interfering | 2012 |
Effects of cytoskeletal modifications on Ca2+ influx after cerebral ischemia.
Topics: Adrenergic alpha-Agonists; Animals; Biological Transport; Brain Ischemia; Calcium; Cerebral Cortex; Cytochalasin D; Cytoskeleton; Gelsolin; In Vitro Techniques; Mice; Mice, Inbred C57BL; N-Methylaspartate; Norepinephrine; Nucleic Acid Synthesis Inhibitors; Potassium; Synaptosomes; Tritium | 2002 |
Treatment of ischemic brain damage by perturbing NMDA receptor- PSD-95 protein interactions.
Topics: Amino Acid Sequence; Animals; Brain; Brain Ischemia; Calcium; Cells, Cultured; Cerebral Infarction; Cyclic GMP; Disks Large Homolog 4 Protein; Guanylate Kinases; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Patch-Clamp Techniques; Peptides; Protein Binding; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Recombinant Fusion Proteins; Signal Transduction; Synaptic Transmission | 2002 |
Effects of hypothermia on neuronal-vascular function after cerebral ischemia in piglets.
Topics: Animals; Arterioles; Brain; Brain Ischemia; Cerebral Arteries; Female; Hypothermia, Induced; Indomethacin; Male; N-Methylaspartate; Swine; Vasodilation | 2002 |
Selective blockade of endothelin-B receptors exacerbates ischemic brain damage in the rat.
Topics: Animals; Antihypertensive Agents; Blood Flow Velocity; Brain Ischemia; Cerebrovascular Circulation; Disease Models, Animal; Endothelin Receptor Antagonists; Excitatory Amino Acid Agonists; Gene Expression; Infarction, Middle Cerebral Artery; Injections, Intraventricular; Male; N-Methylaspartate; Oligopeptides; Piperidines; Rats; Rats, Sprague-Dawley; Receptor, Endothelin B; Receptors, Endothelin; RNA, Messenger | 2002 |
Protective effect of apolipoprotein E-mimetic peptides on N-methyl-D-aspartate excitotoxicity in primary rat neuronal-glial cell cultures.
Topics: Amino Acid Sequence; Animals; Apolipoproteins E; Brain Ischemia; Cells, Cultured; Coculture Techniques; Excitatory Amino Acid Agonists; Molecular Mimicry; Molecular Sequence Data; N-Methylaspartate; Neuroglia; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley | 2003 |
Newborn pig nociceptin/orphanin FQ activates protein tyrosine kinase and mitogen activated protein kinase to impair NMDA cerebrovasodilation after ischemia.
Topics: Animals; Animals, Newborn; Brain Ischemia; Cerebral Arteries; Enzyme Activation; Enzyme Activators; Male; Mitogen-Activated Protein Kinases; N-Methylaspartate; Nociceptin; Opioid Peptides; Protein-Tyrosine Kinases; Swine; Vasodilation | 2003 |
Functional NMDA receptor subtype 2B is expressed in astrocytes after ischemia in vivo and anoxia in vitro.
Topics: 2-Amino-5-phosphonovalerate; Animals; Astrocytes; Axotomy; Brain Ischemia; Calcium; Cell Hypoxia; Cells, Cultured; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glial Fibrillary Acidic Protein; Hippocampus; Immunohistochemistry; Male; N-Methylaspartate; Neurons; Piperidines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 2003 |
Prevention of NMDA-induced death of cortical neurons by inhibition of protein kinase Czeta.
Topics: Animals; Astrocytes; Brain Ischemia; Calcium; Cell Death; Cells, Cultured; Cerebral Cortex; Coculture Techniques; Enzyme Inhibitors; Immunohistochemistry; In Situ Hybridization; Mice; N-Methylaspartate; Neurons; Neuroprotective Agents; Neurotoxins; Peptides; Protein Kinase C; RNA, Messenger | 2003 |
Anti-porin antibodies prevent excitotoxic and ischemic damage to brain tissue.
Topics: Animals; Antibodies; Brain Ischemia; Cell Death; Cell Line; Dogs; Excitatory Amino Acid Agonists; Hippocampus; Humans; Male; N-Methylaspartate; Organ Culture Techniques; Porins; Rats; Rats, Wistar; Voltage-Dependent Anion Channels | 2003 |
A peptide inhibitor of c-Jun N-terminal kinase protects against excitotoxicity and cerebral ischemia.
Topics: Adaptor Proteins, Signal Transducing; Animals; Behavior, Animal; Brain Ischemia; Carrier Proteins; Cells, Cultured; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Gene Products, tat; Genes, fos; In Vitro Techniques; Infarction, Middle Cerebral Artery; JNK Mitogen-Activated Protein Kinases; Male; Mice; Mice, Inbred ICR; Mitogen-Activated Protein Kinases; N-Methylaspartate; Neurons; Neuroprotective Agents; Peptides; Rats; Recombinant Proteins | 2003 |
Excessive production of nitric oxide induces the neuronal cell death in lipopolysaccharide-treated rat hippocampal slice culture.
Topics: Animals; Animals, Newborn; Brain Ischemia; Cell Death; Cerebral Infarction; Enzyme Inhibitors; Hippocampus; Lipopolysaccharides; N-Methylaspartate; Nerve Degeneration; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Organ Culture Techniques; Rats; Rats, Sprague-Dawley; Reaction Time; RNA, Messenger; Up-Regulation | 2003 |
Reduction of ischemic brain damage by nitrous oxide and xenon.
Topics: Anesthetics, Inhalation; Animals; Brain Ischemia; Calcium; Cells, Cultured; Excitatory Amino Acid Agonists; Male; Motor Activity; N-Methylaspartate; Neurons; Neuroprotective Agents; Nitrous Oxide; Postural Balance; Rats; Rats, Sprague-Dawley; Stroke; Xenon | 2003 |
Ectopic expression of the catalytic subunit of telomerase protects against brain injury resulting from ischemia and NMDA-induced neurotoxicity.
Topics: Animals; Brain Injury, Chronic; Brain Ischemia; Calcium; Cells, Cultured; Coculture Techniques; Disease Models, Animal; DNA-Binding Proteins; Excitatory Amino Acid Agonists; Fluorescent Dyes; Gene Expression Regulation; Hypoxia-Ischemia, Brain; Membrane Potentials; Mice; Mice, Transgenic; Mitochondria; N-Methylaspartate; Neuroglia; Neurons; Neurotoxicity Syndromes; Neurotoxins; RNA, Messenger; Telomerase | 2004 |
Prevention of neuron and oligodendrocyte degeneration by interleukin-6 (IL-6) and IL-6 receptor/IL-6 fusion protein in organotypic hippocampal slices.
Topics: Active Transport, Cell Nucleus; Animals; Antigens, CD; Astrocytes; Brain Ischemia; Cytokine Receptor gp130; DNA-Binding Proteins; Gliosis; Hippocampus; In Vitro Techniques; Interleukin-6; Membrane Glycoproteins; Myelin Basic Protein; Myelin Proteolipid Protein; N-Methylaspartate; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Oligodendroglia; Phosphorylation; Rats; Receptors, Interleukin-6; Recombinant Fusion Proteins; RNA, Messenger; STAT1 Transcription Factor; STAT3 Transcription Factor; Trans-Activators | 2004 |
Apoptosis is not an invariable component of in vitro models of cortical cerebral ischaemia.
Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Brain Ischemia; Caspases; Cell Hypoxia; Cell Survival; Cells, Cultured; Cerebral Cortex; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glucose; Models, Biological; N-Methylaspartate; Neurons; Oligopeptides; Oxygen; Rats; Rats, Sprague-Dawley; Staurosporine; Time Factors | 2004 |
Metabotropic glutamate receptors modulate ischemia-induced GABA release in mouse hippocampal slices.
Topics: Animals; Animals, Newborn; Brain Ischemia; gamma-Aminobutyric Acid; Glutamates; Hippocampus; In Vitro Techniques; Kinetics; Mice; N-Methylaspartate; Receptors, Metabotropic Glutamate | 2004 |
Infarct reduction in rats following intraventricular administration of either tissue plasminogen activator (tPA) or its non-protease mutant S478A-tPA.
Topics: Animals; Brain; Brain Infarction; Brain Ischemia; Cells, Cultured; Coculture Techniques; Disease Models, Animal; Endopeptidases; Fetus; Infarction, Middle Cerebral Artery; Injections, Intraventricular; Male; Mice; Movement Disorders; Mutation; N-Methylaspartate; Protein Conformation; Rats; Rats, Sprague-Dawley; Tissue Plasminogen Activator; Treatment Outcome; Zinc | 2004 |
Intraischaemic hypothermia reduces free radical production and protects against ischaemic insults in cultured hippocampal slices.
Topics: Animals; Animals, Newborn; Brain Ischemia; Cell Hypoxia; Cytoprotection; Excitatory Amino Acid Agonists; Fluorescent Dyes; Free Radicals; Glucose; Hippocampus; Hypothermia, Induced; In Vitro Techniques; N-Methylaspartate; Nerve Degeneration; Neurons; Nitric Oxide; Rats; Rats, Wistar; Superoxides; Temperature; Time Factors | 2004 |
Tissue plasminogen activator neurovascular toxicity is controlled by activated protein C.
Topics: Animals; Apoptosis; Brain; Brain Ischemia; Caspase 3; Caspase 8; Caspase 9; Caspase Inhibitors; Caspases; Cells, Cultured; Endothelial Cells; Humans; Immunoblotting; In Situ Nick-End Labeling; Mice; Mice, Inbred C57BL; N-Methylaspartate; Neurons; Protein C; Time Factors; Tissue Plasminogen Activator | 2004 |
2,7-Bis-(4-amidinobenzylidene)-cycloheptan-1-one dihydrochloride, tPA stop, prevents tPA-enhanced excitotoxicity both in vitro and in vivo.
Topics: Animals; Brain Ischemia; Cell Death; Cells, Cultured; Cycloheptanes; Excitatory Amino Acid Agonists; In Vitro Techniques; Male; Mice; N-Methylaspartate; Neurons; Neurotoxins; Rats; Rats, Sprague-Dawley; Serine Proteinase Inhibitors; Signal Transduction; Tissue Plasminogen Activator | 2004 |
Tetraethylammonium exacerbates ischemic neuronal injury in rat cerebrocortical slice cultures.
Topics: Animals; Animals, Newborn; Brain Ischemia; Cell Death; Cerebral Cortex; Charybdotoxin; Dequalinium; Dizocilpine Maleate; Dose-Response Relationship, Drug; N-Methylaspartate; Neurons; Neuroprotective Agents; Organ Culture Techniques; Rats; Rats, Wistar; Sotalol; Tetraethylammonium; Time Factors | 2005 |
Neuroprotection by the PGE2 EP2 receptor in permanent focal cerebral ischemia.
Topics: Aging; Alprostadil; Animals; Brain Ischemia; Cell Death; Cerebral Infarction; Chronic Disease; Excitatory Amino Acid Agonists; Hippocampus; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Neurons; Rats; Rats, Sprague-Dawley; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP2 Subtype | 2005 |
Neuroprotective effects of preconditioning ischaemia on ischaemic brain injury through inhibition of mixed-lineage kinase 3 via NMDA receptor-mediated Akt1 activation.
Topics: Animals; Blotting, Western; Brain; Brain Ischemia; Cell Death; Chromones; Dimethyl Sulfoxide; Disease Models, Animal; Drug Interactions; Enzyme Activation; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Free Radical Scavengers; Ischemic Preconditioning; Ketamine; Male; MAP Kinase Kinase Kinases; Mitogen-Activated Protein Kinase Kinase Kinase 11; Mitogen-Activated Protein Kinase Kinases; Models, Biological; Morpholines; N-Methylaspartate; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Receptors, N-Methyl-D-Aspartate; Reperfusion; Time Factors | 2005 |
The p53-independent nuclear translocation of cyclin G1 in degenerating neurons by ischemic and traumatic insults.
Topics: Animals; Brain Injuries; Brain Ischemia; Cell Death; Cells, Cultured; Cyclin G; Cyclin G1; Cyclins; Cycloheximide; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Embryo, Mammalian; Excitatory Amino Acid Agonists; Fluoresceins; Fluorescent Dyes; Gene Expression Regulation; Gerbillinae; Immunohistochemistry; In Situ Hybridization; In Situ Nick-End Labeling; Kainic Acid; Mice; Mice, Knockout; Microscopy, Immunoelectron; N-Methylaspartate; Nerve Degeneration; Neurons; Organic Chemicals; Phosphopyruvate Hydratase; Protein Synthesis Inhibitors; Rats; Rats, Wistar; Time Factors; Tumor Suppressor Protein p53 | 2005 |
Vampire bat salivary plasminogen activator (desmoteplase) inhibits tissue-type plasminogen activator-induced potentiation of excitotoxic injury.
Topics: Animals; Brain; Brain Ischemia; Calcium; Cell Death; Fibrinolytic Agents; Immunohistochemistry; Infusions, Intravenous; Ischemia; Mice; Mice, Inbred C57BL; N-Methylaspartate; Neurons; Plasminogen Activators; Thrombolytic Therapy; Time Factors; Tissue Plasminogen Activator | 2005 |
An alternative Ca2+-dependent mechanism of neuroprotection by the metalloporphyrin class of superoxide dismutase mimetics.
Topics: Animals; Antioxidants; Brain Ischemia; Calcium; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Catalysis; Cell Membrane; Cells, Cultured; Coculture Techniques; Electrophysiology; Free Radical Scavengers; Glucose; Imidazoles; Metalloporphyrins; Mitochondria; Models, Chemical; N-Methylaspartate; Neurons; Neuroprotective Agents; Oxidation-Reduction; Oxygen; Paraquat; Permeability; Rats; Superoxide Dismutase; Synaptic Transmission; Time Factors | 2005 |
The brain-specific tissue-type plasminogen activator inhibitor, neuroserpin, protects neurons against excitotoxicity both in vitro and in vivo.
Topics: Animals; Apoptosis; Brain; Brain Ischemia; Calcium Signaling; Cells, Cultured; Cerebral Cortex; Corpus Striatum; Disease Models, Animal; Male; Mice; N-Methylaspartate; Neurons; Neuropeptides; Neuroprotective Agents; Neuroserpin; Neurotoxins; Receptors, N-Methyl-D-Aspartate; Serpins; Stroke | 2005 |
Effects of sabiporide, a specific Na+/H+ exchanger inhibitor, on neuronal cell death and brain ischemia.
Topics: Animals; Brain Infarction; Brain Ischemia; Calcium; Cell Death; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Extracellular Space; Glutamic Acid; Guanidines; Mice; N-Methylaspartate; Neurons; Reperfusion; Sodium-Hydrogen Exchangers; Tetrazolium Salts; Thiazoles | 2005 |
Neuroprotective actions of endogenous interleukin-1 receptor antagonist (IL-1ra) are mediated by glia.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Astrocytes; Brain Ischemia; Cell Death; Cells, Cultured; Coculture Techniques; Culture Media, Conditioned; Excitatory Amino Acid Agonists; Infarction, Middle Cerebral Artery; Interleukin 1 Receptor Antagonist Protein; Male; Mice; Mice, Knockout; Microglia; N-Methylaspartate; Neurons; Neuroprotective Agents; Perfusion; Sialoglycoproteins | 2006 |
Kynurenic acid attenuates NMDA-induced pial arteriolar dilation in newborn pigs.
Topics: Analysis of Variance; Animals; Animals, Newborn; Brain Ischemia; Cerebral Arteries; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Hypercapnia; Kynurenic Acid; Male; N-Methylaspartate; Quinolinic Acid; Swine; Time Factors; Vasodilation | 2006 |
Prostaglandin E2 EP1 receptors: downstream effectors of COX-2 neurotoxicity.
Topics: Animals; Brain; Brain Ischemia; Calcium; Cell Death; Cyclooxygenase 2; Dinoprostone; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Neurons; Neurotoxins; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP1 Subtype | 2006 |
Pretreatment with PTD-calbindin D 28k alleviates rat brain injury induced by ischemia and reperfusion.
Topics: Animals; Apoptosis; Blotting, Western; Brain; Brain Ischemia; Calbindins; Calcium; Cell Membrane; Chlorocebus aethiops; COS Cells; Cytosol; Escherichia coli; Excitatory Amino Acid Agonists; Glucose; Hippocampus; Hypoxia, Brain; Immunohistochemistry; In Situ Nick-End Labeling; In Vitro Techniques; Infarction, Middle Cerebral Artery; N-Methylaspartate; Neuroprotective Agents; Rats; Recombinant Proteins; Reperfusion Injury; S100 Calcium Binding Protein G; Signal Transduction | 2007 |
Unconventional neuroprotection against Ca2+ -dependent insults by metalloporphyrin catalytic antioxidants.
Topics: Animals; Antioxidants; Brain Ischemia; Calcium; Calcium Signaling; Catalysis; Cell Membrane; Cells, Cultured; Cerebral Cortex; Excitatory Amino Acid Agonists; Fluoresceins; Glutamic Acid; Metalloporphyrins; N-Methylaspartate; Neurons; Neuroprotective Agents; Neurotoxicity Syndromes; Rats; Reactive Oxygen Species; Sodium-Calcium Exchanger; TRPM Cation Channels | 2006 |
Marked prevention of ischemic brain injury by Neu2000, an NMDA antagonist and antioxidant derived from aspirin and sulfasalazine.
Topics: Animals; Antioxidants; Aspirin; Benzoates; Brain Ischemia; Cells, Cultured; Excitatory Amino Acid Antagonists; Fluorobenzenes; Infarction, Middle Cerebral Artery; meta-Aminobenzoates; Mice; N-Methylaspartate; Oxidative Stress; Receptors, N-Methyl-D-Aspartate; Salicylates; Sulfasalazine | 2007 |
Prolonged activation of ASIC1a and the time window for neuroprotection in cerebral ischaemia.
Topics: Acid Sensing Ion Channels; Acidosis; Animals; Brain; Brain Ischemia; Cerebral Cortex; Cerebral Ventricles; Cerebrovascular Circulation; Disease Models, Animal; Dose-Response Relationship, Drug; Hydrogen-Ion Concentration; Infarction, Middle Cerebral Artery; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; N-Methylaspartate; Nerve Tissue Proteins; Neuroprotective Agents; Sodium Bicarbonate; Sodium Channels; Spider Venoms; Time Factors | 2007 |
[Effects of Ginkgo biloba extract against excitotoxicity induced by NMDA receptors and mechanism thereof].
Topics: Animals; Animals, Newborn; Brain Ischemia; Cell Survival; Cells, Cultured; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Ginkgo biloba; Glycine; Hippocampus; Immunohistochemistry; Male; Membrane Potentials; Microtubule-Associated Proteins; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Nuclear Proteins; Plant Extracts; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reperfusion Injury | 2006 |
Comparison of neuroprotective effects of erythropoietin (EPO) and carbamylerythropoietin (CEPO) against ischemia-like oxygen-glucose deprivation (OGD) and NMDA excitotoxicity in mouse hippocampal slice cultures.
Topics: Animals; Animals, Newborn; Brain Ischemia; Calpain; Coloring Agents; Erythropoietin; Excitatory Amino Acid Agonists; Glucose; Hippocampus; Hypoxia, Brain; In Vitro Techniques; Mice; Mice, Inbred C57BL; Microtubule-Associated Proteins; N-Methylaspartate; Neuroprotective Agents; Propidium; Tolonium Chloride | 2007 |
Subtoxic N-methyl-D-aspartate delayed neuronal death in ischemic brain injury through TrkB receptor- and calmodulin-mediated PI-3K/Akt pathway activation.
Topics: Animals; Brain Infarction; Brain Ischemia; Brain-Derived Neurotrophic Factor; Calcium Signaling; Calmodulin; Cell Survival; Enzyme Activation; Enzyme Inhibitors; Hippocampus; Male; N-Methylaspartate; Nerve Degeneration; Neuroprotective Agents; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Subunits; Proto-Oncogene Proteins c-akt; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptor, trkB; Reperfusion Injury; Signal Transduction | 2007 |
Differential patterns of inflammatory response, axonal damage and myelin impairment following excitotoxic or ischemic damage to the trigeminal spinal nucleus of adult rats.
Topics: Amyloid beta-Protein Precursor; Analysis of Variance; Animals; Axons; Brain Ischemia; Cell Count; Demyelinating Diseases; Ectodysplasins; Endothelin-1; Inflammation; Male; Myelin Basic Protein; N-Methylaspartate; Neurotoxins; Rats; Rats, Wistar; Time Factors; Trigeminal Nucleus, Spinal | 2007 |
Acute astrocyte activation in brain detected by MRI: new insights into T(1) hypointensity.
Topics: Animals; Astrocytes; Brain Ischemia; Endothelin-1; Magnetic Resonance Imaging; N-Methylaspartate; Nervous System Diseases | 2008 |
Testing NMDA receptor block as a therapeutic strategy for reducing ischaemic damage to CNS white matter.
Topics: Action Potentials; Animals; Animals, Newborn; Brain Ischemia; Central Nervous System; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; In Vitro Techniques; Memantine; Myelin Basic Protein; N-Methylaspartate; Oligodendroglia; Patch-Clamp Techniques; Protein Binding; Rats; Receptors, N-Methyl-D-Aspartate | 2008 |
Role of glycine receptors and glycine release for the neuroprotective activity of bilobalide.
Topics: Animals; Binding Sites; Binding, Competitive; Brain Edema; Brain Ischemia; Chlorides; Choline; Cyclopentanes; Excitatory Amino Acid Agonists; Furans; Ginkgolides; Glycine; Hippocampus; Male; Membrane Lipids; N-Methylaspartate; Neuroprotective Agents; Organ Culture Techniques; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate | 2008 |
TNF receptor I sensitizes neurons to erythropoietin- and VEGF-mediated neuroprotection after ischemic and excitotoxic injury.
Topics: Animals; Brain Ischemia; Cell Death; Cytoprotection; Erythropoietin; Excitatory Amino Acid Agonists; Gene Expression Profiling; Kainic Acid; Male; Mice; Mice, Knockout; N-Methylaspartate; Neurons; Oligonucleotide Array Sequence Analysis; Receptors, Erythropoietin; Receptors, Tumor Necrosis Factor, Type I; Tumor Necrosis Factor-alpha; Vascular Endothelial Growth Factor A | 2008 |
Peripheral type benzodiazepine binding sites as a tool for the detection and quantification of CNS injury.
Topics: Animals; Autoradiography; Biomarkers; Brain Chemistry; Brain Injuries; Brain Ischemia; Carrier Proteins; Convulsants; Isoquinolines; Mice; N-Methylaspartate; Nerve Tissue Proteins; Neurotoxins; Protein Binding; Radioligand Assay; Rats; Receptors, GABA; Receptors, GABA-A | 2001 |
Intrauterine hypoxia-ischemia increases N-methyl-D-aspartate-induced cGMP formation and glutamate accumulation in cultured rat cerebellar granule cells.
Topics: Animals; Arginine; Brain Ischemia; Cells, Cultured; Cerebellar Diseases; Chronic Disease; Cyclic GMP; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Fetal Hypoxia; Gestational Age; Glutamic Acid; Hypoxia, Brain; Kainic Acid; N-Methylaspartate; Nitric Oxide Synthase; omega-N-Methylarginine; Rats; Rats, Sprague-Dawley | 1995 |
HU-211, a novel noncompetitive N-methyl-D-aspartate antagonist, improves neurological deficit and reduces infarct volume after reversible focal cerebral ischemia in the rat.
Topics: Animals; Brain Ischemia; Dronabinol; Male; N-Methylaspartate; Neuroprotective Agents; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 1995 |
Excitatory amino acid antagonists protect cochlear auditory neurons from excitotoxicity.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Animals; Brain Ischemia; Cochlea; Cochlear Microphonic Potentials; Dendrites; Electrophysiology; Excitatory Amino Acid Antagonists; Female; Glutamates; Glutamic Acid; Guinea Pigs; Hair Cells, Auditory, Inner; Male; N-Methylaspartate; Neurons, Afferent; Neurotransmitter Agents; Perfusion; Quinoxalines; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate | 1994 |
Propofol protects cultured rat hippocampal neurons against N-methyl-D-aspartate receptor-mediated glutamate toxicity.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Ischemia; Cells, Cultured; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Fetus; Glutamic Acid; Hippocampus; Kainic Acid; N-Methylaspartate; Nerve Degeneration; Neurons; Phosphopyruvate Hydratase; Propofol; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Time Factors | 1994 |
Single glutamate channels in CA1 pyramidal neurones after transient ischaemia.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Ischemia; Gerbillinae; Kainic Acid; N-Methylaspartate; Patch-Clamp Techniques; Pyramidal Cells; Receptors, Glutamate; Time Factors | 1995 |
Toxic NMDA-receptor activation occurs during recovery in a tissue culture model of ischemia.
Topics: Animals; Brain Ischemia; Cells, Cultured; Cerebral Cortex; Culture Techniques; Deoxyglucose; Dose-Response Relationship, Drug; Glutamic Acid; L-Lactate Dehydrogenase; N-Methylaspartate; Neurotoxins; Piperazines; Potassium Cyanide; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1995 |
Quantitative and dynamic MRI of neuroprotection in experimental stroke.
Topics: Animals; Brain Ischemia; Cerebrovascular Disorders; Coloring Agents; Disease Models, Animal; Dizocilpine Maleate; Magnetic Resonance Imaging; N-Methylaspartate; Neurons; Neuroprotective Agents; Rabbits; Tetrazolium Salts | 1995 |
The role of L-type voltage dependent calcium channels in stimulated [3H]norepinephrine release from canine hippocampal slices following global cerebral ischemia and reperfusion.
Topics: Animals; Brain Ischemia; Calcium Channels; Dogs; Female; Hippocampus; N-Methylaspartate; Nitrendipine; Norepinephrine; Potassium; Reperfusion; Time Factors | 1995 |
Post-ischemic therapy with CGS-19755 (alone or in combination with hypothermia) in gerbils.
Topics: Animals; Brain Ischemia; Combined Modality Therapy; Gerbillinae; Hypothermia, Induced; Injections, Intraperitoneal; Male; Maze Learning; N-Methylaspartate; Pipecolic Acids; Prosencephalon | 1995 |
In vitro binding of [3H]nimodipine and [3H]CGS-19755 to rat brain in focal cerebral ischemia.
Topics: Animals; Autoradiography; Binding Sites; Binding, Competitive; Brain; Brain Ischemia; Male; N-Methylaspartate; Nimodipine; Pipecolic Acids; Rats; Rats, Sprague-Dawley; Tritium | 1995 |
Correlation of CGS 19755 neuroprotection against in vitro excitotoxicity and focal cerebral ischemia.
Topics: Animals; Brain; Brain Ischemia; Cerebrovascular Circulation; Evoked Potentials, Somatosensory; In Vitro Techniques; Magnetic Resonance Imaging; Male; Mice; N-Methylaspartate; Neuroprotective Agents; Neurotoxins; Pipecolic Acids; Rabbits | 1995 |
Selective vulnerability of the CA1 region of hippocampus to the indirect excitotoxic effects of malonic acid.
Topics: Animals; Autoradiography; Brain Ischemia; Dizocilpine Maleate; Hippocampus; Hypoxia; Hypoxia, Brain; Male; Malonates; N-Methylaspartate; Rats; Rats, Sprague-Dawley | 1995 |
Neuroprotection by N-methyl-D-aspartate antagonists in focal cerebral ischemia is dependent on continued maintenance dosing.
Topics: Animals; Body Temperature; Brain Edema; Brain Ischemia; Cerebral Cortex; Corpus Striatum; Dextromethorphan; Dextrorphan; Hydrogen-Ion Concentration; N-Methylaspartate; Neuroprotective Agents; Oxygen; Rabbits | 1995 |
Modulation of ischemic signal by antagonists of N-methyl-D-aspartate, nitric oxide synthase, and platelet-activating factor in gerbil hippocampus.
Topics: Animals; Blood Platelets; Brain Ischemia; Disease Models, Animal; Dizocilpine Maleate; Gerbillinae; Hippocampus; N-Methylaspartate; Nitric Oxide; Protein Kinase C; Transcription Factor AP-1 | 1995 |
Distinct neuroprotective profiles for sigma ligands against N-methyl-D-aspartate (NMDA), and hypoxia-mediated neurotoxicity in neuronal culture toxicity studies.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; Benzofurans; Brain Ischemia; Cell Death; Cells, Cultured; Dizocilpine Maleate; Hypoxia; Kainic Acid; Ligands; N-Methylaspartate; Neurons; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Phencyclidine; Receptors, sigma | 1995 |
BW1003C87 and NBQX but not CGS19755 reduce glutamate release and cerebral ischemic necrosis.
Topics: Analysis of Variance; Animals; Binding, Competitive; Brain Ischemia; Disease Models, Animal; Glutamic Acid; Hippocampus; Injections, Intraperitoneal; Injections, Intravenous; Male; Microdialysis; N-Methylaspartate; Necrosis; Neurons; Observer Variation; Pipecolic Acids; Prosencephalon; Pyrimidines; Quinoxalines; Random Allocation; Rats; Rats, Wistar; Receptors, AMPA; Reperfusion Injury | 1994 |
Dextrorphan attenuates the behavioral consequences of ischemia and the biochemical consequences of anoxia: possible role of N-methyl-d-aspartate receptor antagonism and ATP replenishing action in its cerebroprotecting profile.
Topics: Adenosine Triphosphate; Adenylyl Cyclases; Animals; Avoidance Learning; Behavior, Animal; Brain Ischemia; Dextrorphan; Dizocilpine Maleate; Exploratory Behavior; Hypoxia, Brain; Injections, Intraventricular; Male; Maze Learning; Mice; Mice, Inbred ICR; Mice, Inbred Strains; N-Methylaspartate; Nerve Degeneration; Oxidative Phosphorylation; Postural Balance; Potassium Cyanide; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 1993 |
Synthesis, resolution, and SAR of (+/-)-2-amino-N-methyl-alpha-(3-methyl-2-thienyl)benzeneethanamine++ + and related analogs as noncompetitive NMDA antagonists with neuroprotective properties.
Topics: Aniline Compounds; Animals; Anti-Anxiety Agents; Anticonvulsants; Binding, Competitive; Brain Ischemia; Cerebral Infarction; Crystallography, X-Ray; Disease Models, Animal; Gerbillinae; Hippocampus; Isomerism; Male; Mice; Molecular Structure; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship; Thiophenes | 1994 |
NMDA receptors mediate anoxia/aglycemia-induced release of eicosanoids in immature rat hippocampal slices: utility of an in vitro "ischemic" superfusion model with temporary arrest of medium flow.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonic Acid; Brain Ischemia; Calcium; Culture Techniques; Dizocilpine Maleate; Eicosanoids; Hippocampus; Hypoxia; N-Methylaspartate; Quinacrine; Radioimmunoassay; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Thromboxane B2 | 1994 |
Effects of isoflurane and hypothermia on glutamate receptor-mediated calcium influx in brain slices.
Topics: Adenosine Triphosphate; Animals; Brain; Brain Ischemia; Calcium; Cytosol; Excitatory Amino Acid Antagonists; Hypothermia; In Vitro Techniques; Isoflurane; L-Lactate Dehydrogenase; N-Methylaspartate; Rats; Receptors, Glutamate | 1994 |
Protective effects of kamikihi-to, a traditional Chinese medicine, against cerebral ischemia, hypoxia and anoxia in mice and gerbils.
Topics: Animals; Brain Ischemia; Carotid Artery Diseases; Carotid Artery, Common; Cell Death; Drugs, Chinese Herbal; Gerbillinae; Hippocampus; Hypoxia; Male; Medicine, Chinese Traditional; Mice; Mice, Inbred ICR; N-Methylaspartate; Neurons; Potassium Cyanide; Pyramidal Cells | 1994 |
Protective effect of FR115427 against ischemic hippocampal damage in gerbils.
Topics: Animals; Body Temperature; Brain Ischemia; Dizocilpine Maleate; Gerbillinae; Hippocampus; Isoquinolines; Male; Motor Activity; N-Methylaspartate; Pyramidal Cells; Receptors, N-Methyl-D-Aspartate; Tetrahydroisoquinolines | 1994 |
Mortality in gerbils with repetitive ischemia: CGSGS-19755/hypothermia therapy.
Topics: Animals; Brain Ischemia; Cell Death; Combined Modality Therapy; Gerbillinae; Hypothermia, Induced; Male; N-Methylaspartate; Neurons; Pipecolic Acids; Prosencephalon; Recurrence | 1994 |
Hypoxic-ischemic brain injury stimulates glial fibrillary acidic protein mRNA and protein expression in neonatal rats.
Topics: Aging; Animals; Animals, Newborn; Blotting, Northern; Brain; Brain Ischemia; Cerebral Cortex; Corpus Striatum; Dizocilpine Maleate; Functional Laterality; Glial Fibrillary Acidic Protein; Hippocampus; Hypoxia, Brain; Immunohistochemistry; N-Methylaspartate; Organ Specificity; Rats; Rats, Sprague-Dawley; RNA, Messenger | 1994 |
Effect of radix salviae miltiorrhizae on EAA and IAA during cerebral ischemia in gerbils: a microdialysis study.
Topics: Amino Acids; Animals; Brain Ischemia; Drugs, Chinese Herbal; Extracellular Space; gamma-Aminobutyric Acid; Gerbillinae; Glutamates; Microdialysis; N-Methylaspartate; Plant Extracts; Salvia miltiorrhiza | 1994 |
Increased activation of L-type voltage-dependent calcium channels is associated with glycine enhancement of N-methyl-D-aspartate-stimulated dopamine release in global cerebral ischemia/reperfusion.
Topics: Animals; Brain Ischemia; Calcium Channels; Dogs; Dopamine; Female; Glycine; Isradipine; N-Methylaspartate; Nitrendipine; Reperfusion Injury; Time Factors; Tritium | 1994 |
A dose-response study of dextrorphan in permanent focal ischemia.
Topics: Analysis of Variance; Animals; Basal Ganglia; Blood Gas Analysis; Blood Pressure; Brain Ischemia; Cerebral Arteries; Cerebral Infarction; Dextrorphan; Dose-Response Relationship, Drug; N-Methylaspartate; Rats | 1993 |
NMDA and glycine receptor mRNA expression following transient global ischemia in the gerbil brain.
Topics: Animals; Base Sequence; Brain Ischemia; Gerbillinae; Glycine; Hippocampus; Male; Molecular Sequence Data; N-Methylaspartate; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; RNA, Messenger | 1993 |
Antagonism of the NMDA and non-NMDA receptors in global versus focal brain ischemia.
Topics: Animals; Brain Ischemia; Excitatory Amino Acid Antagonists; Ischemic Attack, Transient; N-Methylaspartate; Rats; Rats, Wistar; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate | 1993 |
Acute experimental neuronal injury in the newborn lamb: US characterization and demonstration of hemodynamic effects.
Topics: Acute Disease; Animals; Animals, Newborn; Blood Flow Velocity; Brain; Brain Ischemia; Cerebrovascular Circulation; Cerebrovascular Disorders; Echoencephalography; Hemodynamics; N-Methylaspartate; Oxygen Consumption; Sheep | 1993 |
Pharmacological profile of NPC 17742 [2R,4R,5S-(2-amino-4,5-(1, 2-cyclohexyl)-7-phosphonoheptanoic acid)], a potent, selective and competitive N-methyl-D-aspartate receptor antagonist.
Topics: Amino Acids; Animals; Anticonvulsants; Behavior, Animal; Binding, Competitive; Brain Ischemia; Electrophysiology; Female; Gerbillinae; Hippocampus; Male; Mice; Mice, Inbred Strains; N-Methylaspartate; Oocytes; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Xenopus laevis | 1993 |
Basic fibroblast growth factor protects against hypoxia-ischemia and NMDA neurotoxicity in neonatal rats.
Topics: Animals; Animals, Newborn; Body Temperature; Brain; Brain Ischemia; Female; Fibroblast Growth Factor 2; Hypoxia; N-Methylaspartate; Pregnancy; Rats | 1993 |
Dopamine release from canine striatum following global cerebral ischemia/reperfusion.
Topics: Animals; Brain Ischemia; Corpus Striatum; Dogs; Dopamine; Female; Heart Arrest, Induced; N-Methylaspartate; Potassium; Reperfusion Injury | 1993 |
Cardiovascular responses to global cerebral ischemia: role of excitatory amino acids in the ventrolateral medullary pressor area.
Topics: Acetylcholine; Amino Acids; Animals; Antidiuretic Hormone Receptor Antagonists; Atropine; Blood Pressure; Brain Ischemia; Dose-Response Relationship, Drug; Glutamates; Heart Rate; Kainic Acid; Kynurenic Acid; Male; Medulla Oblongata; Muscimol; N-Methylaspartate; Quinoxalines; Quisqualic Acid; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Receptors, Vasopressin; Vasopressins | 1993 |
Antisense oligodeoxynucleotides to NMDA-R1 receptor channel protect cortical neurons from excitotoxicity and reduce focal ischaemic infarctions.
Topics: Animals; Base Sequence; Brain Ischemia; Calcium; Cells, Cultured; Cerebral Arteries; Cerebral Cortex; Cerebral Infarction; Down-Regulation; Male; Molecular Sequence Data; N-Methylaspartate; Neurons; Oligonucleotides, Antisense; Rats; Rats, Inbred SHR; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; RNA, Messenger | 1993 |
A dose-response study of neuroprotection using the AMPA antagonist NBQX in rat focal cerebral ischemia.
Topics: Animals; Brain; Brain Ischemia; Cerebral Arteries; Cerebral Infarction; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Heat-Shock Proteins; Male; N-Methylaspartate; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA | 1996 |
Structure-activity relationships in a series of 2(1H)-quinolones bearing different acidic function in the 3-position: 6,7-dichloro-2(1H)-oxoquinoline-3-phosphonic acid, a new potent and selective AMPA/kainate antagonist with neuroprotective properties.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain; Brain Ischemia; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Gerbillinae; Kainic Acid; Mice; Molecular Structure; N-Methylaspartate; Neuroprotective Agents; Organophosphonates; Quinolones; Quinoxalines; Rats; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship; Xenopus | 1996 |
Microglial response to N-methyl-D-aspartate-mediated excitotoxicity in the immature rat brain.
Topics: Animals; Brain Ischemia; Disease Models, Animal; Efferent Pathways; Female; Hippocampus; Male; Microglia; N-Methylaspartate; Nerve Degeneration; Rats; Somatosensory Cortex; Thalamus; Wallerian Degeneration | 1996 |
Nitric oxide inhibitors attenuate ischemic degeneration in the CA1 region of rat hippocampal slices.
Topics: Animals; Brain Ischemia; Enzyme Inhibitors; Glucose; Hippocampus; Hypoxia, Brain; Indazoles; N-Methylaspartate; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Rats | 1996 |
Ultrastructural morphological changes are not characteristic of apoptotic cell death following focal cerebral ischaemia in the rat.
Topics: Animals; Apoptosis; Biotin; Brain Ischemia; Chromatin; Deoxyuracil Nucleotides; DNA Fragmentation; Mammillary Bodies; Microinjections; Microscopy, Electron; N-Methylaspartate; Neurons; Rats; Rats, Sprague-Dawley; Rats, Wistar; Staining and Labeling | 1996 |
Biexponential diffusion attenuation in various states of brain tissue: implications for diffusion-weighted imaging.
Topics: Age Factors; Animals; Animals, Newborn; Brain Edema; Brain Ischemia; Diffusion; Dizocilpine Maleate; Electric Impedance; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Extracellular Space; Intracellular Fluid; Magnetic Resonance Spectroscopy; N-Methylaspartate; Phantoms, Imaging; Rats; Rats, Wistar; Water | 1996 |
Effects of ischemia on cerebrovascular responses to N-methyl-D-aspartate in piglets.
Topics: Animals; Arterioles; Brain; Brain Ischemia; Cerebrovascular Circulation; Female; Male; N-Methylaspartate; Nitric Oxide Synthase; Nitroprusside; Superoxide Dismutase; Swine; Vasodilation | 1996 |
Dextromethorphan reduces functional deficits and neuronal damage after global ischemia in rats.
Topics: Animals; Behavior, Animal; Brain Ischemia; Dextromethorphan; Male; Maze Learning; Memory; Motor Activity; N-Methylaspartate; Nerve Degeneration; Neurons; Neuroprotective Agents; Rats; Rats, Wistar | 1996 |
Effect of D-(E)-2-amino-4-methyl-5-phosphono-3-pentenoic acid on ischemic brain damage induced by four-vessel occlusion in rats.
Topics: 2-Amino-5-phosphonovalerate; Adenosine Triphosphate; Animals; Avoidance Learning; Brain Chemistry; Brain Ischemia; Cerebrovascular Circulation; Energy Metabolism; Excitatory Amino Acid Antagonists; Male; Motor Activity; N-Methylaspartate; Rats; Rats, Inbred F344 | 1997 |
Monitoring cellular edema at single-neuron level by electrical resistance measurements.
Topics: Animals; Brain Edema; Brain Ischemia; Carotid Arteries; Electric Impedance; Excitatory Amino Acid Agonists; Extracellular Space; Glass; Hippocampus; Iontophoresis; Ligation; Microelectrodes; N-Methylaspartate; Neurons; Rats | 1997 |
Functional interaction between Na(+)-K+ pump and KATP channels in the CNS neurons under experimental brain ischemia.
Topics: Adenosine Triphosphate; Animals; Brain Ischemia; Calcium; Cytosol; Electric Conductivity; Excitatory Amino Acid Agonists; Hypoglycemia; Hypoxia; Locus Coeruleus; N-Methylaspartate; Neurons; Osmolar Concentration; Potassium Channels; Rats; Sodium-Potassium-Exchanging ATPase | 1997 |
Ca2+-activated K+ currents in rat locus coeruleus neurons induced by experimental ischemia, anoxia, and hypoglycemia.
Topics: Animals; Brain Ischemia; Calcium; Calcium Channels; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Charybdotoxin; Glucose; Glyburide; Hypoglycemia; Hypoxia, Brain; In Vitro Techniques; Locus Coeruleus; Membrane Potentials; N-Methylaspartate; Neurons; Oxygen; Partial Pressure; Rats; Rats, Wistar; Ryanodine; Sodium Cyanide; Thapsigargin; Tolbutamide | 1997 |
Intracellular free Ca2+ elevations in cultured astroglia induced by neuroligands playing a role in cerebral ischemia.
Topics: Adenosine Triphosphate; Adrenergic alpha-Agonists; Animals; Animals, Newborn; Astrocytes; Brain Ischemia; Calcium; Cells, Cultured; Cytoplasm; Excitatory Amino Acid Agonists; Extracellular Space; Fluorescent Dyes; Fura-2; Glutamic Acid; Kainic Acid; N-Methylaspartate; Neurotransmitter Agents; Norepinephrine; Quisqualic Acid; Rats; Receptors, Glutamate; Serotonin; Spectrometry, Fluorescence; Vasoconstrictor Agents; Vasopressins | 1997 |
Fenamates protect neurons against ischemic and excitotoxic injury in chick embryo retina.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain Ischemia; Chick Embryo; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Flufenamic Acid; Glucose; Kainic Acid; Meclofenamic Acid; Mefenamic Acid; N-Methylaspartate; Neuroprotective Agents; Neurotoxins; Organ Culture Techniques; ortho-Aminobenzoates; Oxygen; Patch-Clamp Techniques; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Retinal Ganglion Cells | 1998 |
Evidence that functional glutamate receptors are not expressed on rat or human cerebromicrovascular endothelial cells.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Ischemia; Calcium; Capillaries; Cattle; Cells, Cultured; Cerebrovascular Circulation; Colforsin; Cyclic AMP; Cycloleucine; Endothelin-1; Endothelium, Vascular; Gene Expression; Humans; Inositol 1,4,5-Trisphosphate; Kainic Acid; Mice; N-Methylaspartate; Neurons; Polymerase Chain Reaction; Rats; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Second Messenger Systems | 1998 |
Striatal spiny neurons and cholinergic interneurons express differential ionotropic glutamatergic responses and vulnerability: implications for ischemia and Huntington's disease.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Ischemia; Cells, Cultured; Cerebral Cortex; Cholinergic Fibers; Corpus Striatum; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Huntington Disease; Interneurons; Kainic Acid; Membrane Potentials; N-Methylaspartate; Neurotoxins; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 1998 |
Ethanol, stroke, brain damage, and excitotoxicity.
Topics: Animals; Autoradiography; Body Temperature; Brain; Brain Ischemia; Cells, Cultured; Central Nervous System Depressants; Cerebrovascular Disorders; Ethanol; Excitatory Amino Acid Agonists; Gerbillinae; Hippocampus; Male; N-Methylaspartate; Neurons; Nitric Oxide Synthase; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 1998 |
Calbindin-D28k fails to protect hippocampal neurons against ischemia in spite of its cytoplasmic calcium buffering properties: evidence from calbindin-D28k knockout mice.
Topics: Animals; Brain Ischemia; Buffers; Calbindin 1; Calbindins; Calcium; Cytoplasm; Glucose; Hippocampus; In Vitro Techniques; Ion Channels; Mice; Mice, Inbred Strains; Mice, Knockout; N-Methylaspartate; Nerve Tissue Proteins; Oxygen; S100 Calcium Binding Protein G | 1998 |
Excitotoxin-induced cerebral hyperemia in newborn piglets: regional cerebral blood flow mapping with contrast-enhanced power Doppler US.
Topics: Animals; Animals, Newborn; Area Under Curve; Basal Ganglia; Blood Pressure; Brain Diseases; Brain Ischemia; Carbon Dioxide; Cerebrovascular Circulation; Contrast Media; Corpus Striatum; Disease Models, Animal; Excitatory Amino Acid Agonists; Feasibility Studies; Fluorocarbons; Hyperemia; Hypoxia, Brain; Image Enhancement; Injections; Injections, Intravenous; N-Methylaspartate; Swine; Time Factors; Ultrasonography, Doppler; Vasodilator Agents | 1998 |
Ischemic tolerance in murine cortical cell culture: critical role for NMDA receptors.
Topics: Animals; Brain Ischemia; Cell Death; Cell Hypoxia; Cells, Cultured; Cerebral Cortex; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Fetus; Glucose; Mice; N-Methylaspartate; Neurons; Neuroprotective Agents; Piperazines; Receptors, N-Methyl-D-Aspartate; Time Factors | 1999 |
Changes in the diffusion of water and intracellular metabolites after excitotoxic injury and global ischemia in neonatal rat brain.
Topics: Animals; Animals, Newborn; Body Water; Brain Diseases; Brain Ischemia; Diffusion; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Intracellular Fluid; N-Methylaspartate; Rats; Rats, Wistar | 1999 |
Treatment of acute ischemic stroke: where are we?
Topics: Animals; Aspirin; Brain Damage, Chronic; Brain Ischemia; Calcium Channel Blockers; Cerebral Hemorrhage; Cerebrovascular Circulation; Clinical Trials as Topic; Fibrinolytic Agents; Heparin; Heparin, Low-Molecular-Weight; Humans; N-Methylaspartate; Neuroprotective Agents; Platelet Aggregation Inhibitors; Reperfusion Injury; Rodentia; Thrombolytic Therapy; Warfarin | 1999 |
Heparin-binding epidermal growth factor-like growth factor mRNA expression in neonatal rat brain with hypoxic/ischemic injury.
Topics: Animals; Animals, Newborn; Blotting, Northern; Brain Chemistry; Brain Ischemia; DNA Probes; Epidermal Growth Factor; Excitatory Amino Acid Agonists; Gene Expression; Heparin-binding EGF-like Growth Factor; Hypoxia; Hypoxia, Brain; In Situ Hybridization; Intercellular Signaling Peptides and Proteins; Microinjections; N-Methylaspartate; Rats; Rats, Sprague-Dawley; RNA, Messenger; Transcription, Genetic | 1999 |
Forebrain ischemia: effect on pharmacologically induced seizure thresholds in the rat.
Topics: Analysis of Variance; Animals; Brain Ischemia; Convulsants; Lidocaine; Male; N-Methylaspartate; Pentylenetetrazole; Picrotoxin; Prosencephalon; Rats; Rats, Sprague-Dawley; Seizures | 1999 |
Ascorbic acid is neuroprotective against global ischaemia in striatum but not hippocampus: histological and voltammetric data.
Topics: Alkylating Agents; Animals; Ascorbic Acid; Brain Ischemia; Corpus Striatum; Dopamine; Drug Interactions; Electrochemistry; Ethylmaleimide; Gerbillinae; Hippocampus; Male; N-Methylaspartate; Nerve Degeneration; Neuroprotective Agents; Rats; Rats, Wistar | 1999 |
Ischaemic pre-conditioning in organotypic hippocampal slice cultures is inversely correlated to the induction of the 72 kDa heat shock protein (HSP72).
Topics: Animals; Brain Ischemia; Excitatory Amino Acid Agonists; Glutamic Acid; Heat-Shock Proteins; Hippocampus; HSP72 Heat-Shock Proteins; Ischemic Preconditioning; Kainic Acid; N-Methylaspartate; Nerve Degeneration; Neurotoxins; Organ Culture Techniques; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 1999 |
Mitochondrial potassium channel opener diazoxide preserves neuronal-vascular function after cerebral ischemia in newborn pigs.
Topics: Animals; Animals, Newborn; Arterioles; Brain Ischemia; Decanoic Acids; Diazoxide; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Female; Hydroxy Acids; Male; Mitochondria; N-Methylaspartate; Neurons; Pia Mater; Picolines; Potassium Channels; Pyrans; Vasodilator Agents | 1999 |
Heme oxygenase-2 is neuroprotective in cerebral ischemia.
Topics: Animals; Antioxidants; Brain; Brain Ischemia; Heme Oxygenase (Decyclizing); Immunohistochemistry; In Situ Hybridization; Male; Mice; N-Methylaspartate; Reperfusion | 1999 |
MRZ 2/579, a novel uncompetitive N-methyl-D-aspartate antagonist, reduces infarct volume and brain swelling and improves neurological deficit after focal cerebral ischemia in rats.
Topics: Animals; Brain Edema; Brain Ischemia; Cerebral Cortex; Cyclopentanes; Excitatory Amino Acid Agonists; Image Processing, Computer-Assisted; Infarction, Middle Cerebral Artery; Male; N-Methylaspartate; Neostriatum; Neurologic Examination; Neuroprotective Agents; Rats; Rats, Sprague-Dawley | 2000 |
Acute decrease in net glutamate uptake during energy deprivation.
Topics: 2-Amino-5-phosphonovalerate; Amino Acid Transport System X-AG; Animals; Aspartic Acid; ATP-Binding Cassette Transporters; Biological Transport; Brain Ischemia; Dicarboxylic Acids; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; Kinetics; Membrane Potentials; N-Methylaspartate; Neurotransmitter Uptake Inhibitors; Organ Culture Techniques; Patch-Clamp Techniques; Pyrrolidines; Quinoxalines; Rats | 2000 |
NOC/oFQ contributes to hypoxic-ischemic impairment of N-methyl-D-aspartate-induced cerebral vasodilation.
Topics: Animals; Animals, Newborn; Blood Gas Analysis; Blood Pressure; Brain Ischemia; Cerebrovascular Circulation; Excitatory Amino Acid Agonists; Female; Glutamic Acid; Hypoxia, Brain; Male; N-Methylaspartate; Nociceptin; Opioid Peptides; Pia Mater; Receptors, N-Methyl-D-Aspartate; Reperfusion Injury; Swine; Vasodilation | 2000 |
Effect of carnosine on rats under experimental brain ischemia.
Topics: Animals; Antioxidants; Brain; Brain Ischemia; Carnosine; Exploratory Behavior; Glutamic Acid; Male; Maze Learning; Monoamine Oxidase; N-Methylaspartate; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Synaptosomes | 2000 |
Interleukin-10 modulates neuronal threshold of vulnerability to ischaemic damage.
Topics: Animals; Brain; Brain Ischemia; Cell Death; Cells, Cultured; Excitatory Amino Acid Agonists; Glucose; Infarction, Middle Cerebral Artery; Interleukin-10; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Necrosis; Neurons; Neurotoxins; Oxygen; Recombinant Proteins; Tumor Necrosis Factor-alpha | 2000 |
GDNF and neublastin protect against NMDA-induced excitotoxicity in hippocampal slice cultures.
Topics: Animals; Brain Ischemia; Cell Death; Cells, Cultured; Culture Media, Conditioned; Glial Cell Line-Derived Neurotrophic Factor; Hippocampus; N-Methylaspartate; Nerve Growth Factors; Nerve Tissue Proteins; Neuroprotective Agents; Neurotoxins; Propidium; Pyramidal Cells; Rats; Time Factors | 2000 |
Complement anaphylatoxin C3a is selectively protective against NMDA-induced neuronal cell death.
Topics: Anaphylatoxins; Animals; Apoptosis; Astrocytes; Brain Ischemia; Cells, Cultured; Cerebral Cortex; Coculture Techniques; Complement C3a; Excitatory Amino Acid Agonists; Gene Expression; Guinea Pigs; Mice; Mice, Inbred Strains; N-Methylaspartate; Neurons; Neurotoxins; RNA, Messenger | 2001 |
Anoxic depolarization mediates acute damage independent of glutamate in neocortical brain slices.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Brain Ischemia; Cortical Spreading Depression; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Hypoxia; Kynurenic Acid; Male; N-Methylaspartate; Neocortex; Neurons; Rats; Rats, Sprague-Dawley; Receptors, Glutamate | 2001 |
Neuroprotection mediated by glial cell line-derived neurotrophic factor: involvement of a reduction of NMDA-induced calcium influx by the mitogen-activated protein kinase pathway.
Topics: Animals; Apoptosis; Astrocytes; Brain Ischemia; Calcium; Cerebral Cortex; Chelating Agents; Drosophila Proteins; Fluorescent Dyes; Glial Cell Line-Derived Neurotrophic Factor; Glial Cell Line-Derived Neurotrophic Factor Receptors; Glycosylphosphatidylinositols; MAP Kinase Signaling System; Membrane Proteins; Mice; Mice, Inbred Strains; Mitogen-Activated Protein Kinases; N-Methylaspartate; Necrosis; Nerve Growth Factors; Nerve Tissue Proteins; Neurons; Neuroprotective Agents; Oxidation-Reduction; Phosphorylation; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ret; Receptor Protein-Tyrosine Kinases; RNA, Messenger | 2001 |
Interleukin-1beta exacerbates hypoxia-induced neuronal damage, but attenuates toxicity produced by simulated ischaemia and excitotoxicity in rat organotypic hippocampal slice cultures.
Topics: Animals; Brain Ischemia; Culture Techniques; Dose-Response Relationship, Drug; Glucose; Hippocampus; Hypoxia; Interleukin 1 Receptor Antagonist Protein; Interleukin-1; N-Methylaspartate; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Osmolar Concentration; Rats; Rats, Wistar; Sialoglycoproteins | 2001 |
Reducing conditions produce a loss of neuroprotective efficacy of competitive but not non-competitive antagonists in a model of NMDA-mediated excitotoxicity in organotypic hippocampal slice cultures.
Topics: Animals; Brain Edema; Brain Ischemia; Culture Techniques; Dose-Response Relationship, Drug; Hippocampus; N-Methylaspartate; Neuroprotective Agents; Rats; Rats, Wistar | 2000 |
Neuroprotective properties of the novel antiepileptic drug levetiracetam in the rat middle cerebral artery occlusion model of focal cerebral ischemia.
Topics: Animals; Anticonvulsants; Arterial Occlusive Diseases; Body Temperature; Brain; Brain Ischemia; Cerebrovascular Circulation; Disease Models, Animal; Dizocilpine Maleate; Levetiracetam; Male; Middle Cerebral Artery; N-Methylaspartate; Neuroprotective Agents; Piracetam; Rats; Rats, Wistar | 2001 |
Cross-tolerance to otherwise lethal N-methyl-D-aspartate and oxygen-glucose deprivation in preconditioned cortical cultures.
Topics: Aniline Compounds; Animals; Biomarkers; Brain Ischemia; Calcium; Calpain; Cells, Cultured; Cerebral Cortex; Excitatory Amino Acid Agonists; Female; Fluorescent Antibody Technique; Fluorescent Dyes; Glucose; Ischemic Preconditioning; Microtubule-Associated Proteins; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Oxygen; Pregnancy; Rats; Xanthenes | 2001 |
Increased susceptibility to ischemic brain injury in cyclooxygenase-1-deficient mice.
Topics: Animals; Brain; Brain Ischemia; Cerebrovascular Circulation; Cyclooxygenase 1; Disease Susceptibility; Excitatory Amino Acid Agonists; Female; Infarction, Middle Cerebral Artery; Isoenzymes; Kainic Acid; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Neurotoxins; Parietal Lobe; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Stroke | 2001 |
Nitric-oxide-synthase-mediated cyclic guanosine monophosphate production in neonatal rat cerebellar prisms is resistant to calcineurin inhibition.
Topics: Animals; Animals, Newborn; Brain Ischemia; Calcineurin; Calcineurin Inhibitors; Cerebellum; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Female; Immunosuppressive Agents; Male; N-Methylaspartate; Neurons; Neuroprotective Agents; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Phosphorylation; Phosphoserine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Tacrolimus | 2002 |
Mechanism of detection of acute cerebral ischemia in rats by diffusion-weighted magnetic resonance microscopy.
Topics: Acute Disease; Animals; Brain; Brain Ischemia; Diffusion; Female; Glutamates; Glutamic Acid; Magnetic Resonance Imaging; N-Methylaspartate; Ouabain; Rats; Rats, Inbred Strains; Staining and Labeling | 1992 |
Effect of NO synthase inhibition on NMDA- and ischaemia-induced hippocampal lesions.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Oxidoreductases; Animals; Arginine; Brain Ischemia; Dose-Response Relationship, Drug; Hippocampus; Ibotenic Acid; Male; N-Methylaspartate; Neurons; Neurotoxins; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Pyramidal Tracts; Rats; Rats, Wistar | 1992 |
Neuroprotective effects of L-kynurenine on hypoxia-ischemia and NMDA lesions in neonatal rats.
Topics: Animals; Animals, Newborn; Brain Ischemia; Cerebral Cortex; Disease Models, Animal; Dose-Response Relationship, Drug; Kynurenic Acid; Kynurenine; N-Methylaspartate; Probenecid; Proto-Oncogene Proteins c-fos; Rats; Rats, Inbred Strains | 1992 |
Ketamine decreases plasma catecholamines and improves outcome from incomplete cerebral ischemia in rats.
Topics: Animals; Blood Glucose; Blood Pressure; Brain; Brain Ischemia; Cerebrovascular Circulation; Electroencephalography; Epinephrine; Fentanyl; Ketamine; Male; N-Methylaspartate; Norepinephrine; Oxygen Consumption; Quinoxalines; Rats; Rats, Inbred Strains | 1992 |
A mouse model of focal cerebral ischemia for screening neuroprotective drug effects.
Topics: Animals; Brain Ischemia; Calcium Channel Blockers; Cerebral Arteries; Cerebral Infarction; Disease Models, Animal; Drug Evaluation, Preclinical; Electrocoagulation; Male; Mice; N-Methylaspartate; Serotonin | 1992 |
Effects of glutamate, quisqualate, and N-methyl-D-aspartate in neonatal brain.
Topics: Amino Acids; Animals; Animals, Newborn; Brain; Brain Ischemia; Female; Glucose; Glutamates; Glutamic Acid; Male; N-Methylaspartate; Organ Specificity; Phosphocreatine; Quisqualic Acid; Rats; Rats, Inbred Strains | 1991 |
[Selective vulnerability of peptide-containing neurons in cerebral ischemia; immunohistochemical study].
Topics: Animals; Brain Ischemia; Catecholamines; Cerebral Cortex; Gerbillinae; Immunohistochemistry; N-Methylaspartate; Neurons; Neuropeptide Y; Neuropeptides; Somatostatin; Vasoactive Intestinal Peptide | 1991 |
Efficacy of LY233053, a competitive glutamate antagonist, in experimental central nervous system ischemia.
Topics: Animals; Brain Ischemia; Dose-Response Relationship, Drug; Ischemia; N-Methylaspartate; Pipecolic Acids; Rabbits; Spinal Cord; Tetrazoles | 1992 |
In vivo distribution of CGS-19755 within brain in a model of focal cerebral ischemia.
Topics: Animals; Brain; Brain Ischemia; Electrocoagulation; Male; N-Methylaspartate; Pipecolic Acids; Rats; Rats, Inbred Strains; Reference Values; Tissue Distribution | 1992 |
Effects of monosialoganglioside GM1 in experimental models of ischemic brain damage.
Topics: Animals; Brain; Brain Damage, Chronic; Brain Ischemia; Choline O-Acetyltransferase; G(M1) Ganglioside; Injections, Intraventricular; N-Methylaspartate; Organ Size; Ouabain; Rats | 1991 |
Neuroprotective properties of 5-HT1A receptor agonists in rodent models of focal and global cerebral ischemia.
Topics: Animals; Body Temperature; Brain; Brain Ischemia; Disease Models, Animal; Hypothalamus, Posterior; Ischemic Attack, Transient; Male; Mice; N-Methylaspartate; Phencyclidine; Pyridines; Rats; Rats, Inbred Strains; Receptors, Serotonin | 1991 |
The effects of a competitive NMDA receptor antagonist (CGS-19755) on cerebral blood flow and pH in focal ischemia.
Topics: Animals; Brain Ischemia; Cerebrovascular Circulation; Hydrogen-Ion Concentration; Male; N-Methylaspartate; Pipecolic Acids; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 1991 |
Evaluation of a competitive NMDA antagonist (D-CPPene) in feline focal cerebral ischemia.
Topics: Animals; Binding, Competitive; Brain; Brain Ischemia; Cats; Caudate Nucleus; Cerebral Cortex; Dizocilpine Maleate; Drug Administration Schedule; Half-Life; N-Methylaspartate; Piperazines; Receptors, N-Methyl-D-Aspartate | 1991 |
Effects of hypoxia-ischemia and MK-801 treatment on the binding of a phencyclidine analogue in the developing rat brain.
Topics: Animals; Animals, Newborn; Aspartic Acid; Autoradiography; Binding Sites; Brain; Brain Ischemia; Dibenzocycloheptenes; Dizocilpine Maleate; Glutamates; Glutamic Acid; Hypoxia; N-Methylaspartate; Phencyclidine; Rats; Rats, Inbred Strains; Tritium | 1990 |
Effects of hypoxia and hypoglycaemia on DC potentials recorded from the gerbil hippocampus in vitro.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Ischemia; Cell Hypoxia; gamma-Aminobutyric Acid; Gerbillinae; Hippocampus; Hypoglycemia; Ibotenic Acid; In Vitro Techniques; Kainic Acid; Male; Membrane Potentials; N-Methylaspartate | 1990 |
Postischemic synaptic excitation and N-methyl-D-aspartate receptor activation in gerbils.
Topics: Animals; Brain Ischemia; Gerbillinae; Male; Membrane Potentials; N-Methylaspartate; Piperazines; Receptors, N-Methyl-D-Aspartate; Synaptic Membranes | 1990 |
2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline: a neuroprotectant for cerebral ischemia.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Brain Ischemia; Cerebral Cortex; Hippocampus; Ibotenic Acid; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Neurons; Oxadiazoles; Pyramidal Tracts; Quinoxalines; Quisqualic Acid; Rats; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, Neurotransmitter | 1990 |
Protection by NMDA antagonists against selective cell loss following transient ischaemia.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Brain; Brain Ischemia; Dibenzocycloheptenes; Dizocilpine Maleate; Male; N-Methylaspartate; Neurons; Pipecolic Acids; Piperazines; Piperidines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
N-methyl-D-aspartate and non-N-methyl-D-aspartate antagonists in global cerebral ischemia.
Topics: Animals; Brain Ischemia; Glutamates; Hippocampus; N-Methylaspartate | 1990 |
Comparison of phenytoin with noncompetitive N-methyl-D-aspartate antagonists in a model of focal brain ischemia in rat.
Topics: Animals; Brain Ischemia; Disease Models, Animal; Dizocilpine Maleate; Male; N-Methylaspartate; Phencyclidine; Phenytoin; Rats; Rats, Inbred F344 | 1990 |
Preclinical anticonvulsant and neuroprotective profile of 8319, a non-competitive NMDA antagonist.
Topics: Aniline Compounds; Animals; Anticonvulsants; Binding, Competitive; Brain Diseases; Brain Ischemia; Dizocilpine Maleate; Gerbillinae; Hippocampus; Male; Mice; Mice, Inbred Strains; N-Methylaspartate; Rats; Rats, Inbred Strains; Thiophenes; Tritium | 1990 |
Pharmacological profile of NPC 12626, a novel, competitive N-methyl-D-aspartate receptor antagonist.
Topics: Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Binding, Competitive; Brain; Brain Ischemia; Cerebral Ventricles; Corpus Striatum; Electric Conductivity; Female; Gerbillinae; In Vitro Techniques; Male; Membranes; N-Methylaspartate; Oocytes; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures; Xenopus | 1989 |
Excitatory amino acid binding sites in the rat hippocampus after transient forebrain ischemia.
Topics: Amino Acids; Animals; Aspartic Acid; Binding Sites; Brain Ischemia; Diencephalon; Hippocampus; Male; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Telencephalon | 1989 |
Sensitivity of the developing rat brain to hypobaric/ischemic damage parallels sensitivity to N-methyl-aspartate neurotoxicity.
Topics: Air Pressure; Animals; Animals, Newborn; Aspartic Acid; Atmospheric Pressure; Brain; Brain Ischemia; Disease Susceptibility; Microinjections; N-Methylaspartate; Nerve Degeneration; Neurons; Rats; Rats, Inbred Strains | 1989 |
Effect of the NMDA antagonist MK-801 on local cerebral blood flow in focal cerebral ischaemia in the rat.
Topics: Animals; Aspartic Acid; Blood Pressure; Brain Ischemia; Cerebrovascular Circulation; Dibenzocycloheptenes; Dizocilpine Maleate; Male; N-Methylaspartate; Rats; Rats, Inbred Strains | 1989 |
Ifenprodil and SL 82.0715 as cerebral anti-ischemic agents. II. Evidence for N-methyl-D-aspartate receptor antagonist properties.
Topics: Animals; Aspartic Acid; Brain Ischemia; Cells, Cultured; Cerebellum; Corpus Striatum; Cyclic GMP; Dopamine; Harmaline; In Vitro Techniques; Mice; N-Methylaspartate; Phencyclidine; Piperazines; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Spinal Cord | 1988 |
Ifenprodil and SL 82.0715 as cerebral anti-ischemic agents. I. Evidence for efficacy in models of focal cerebral ischemia.
Topics: Animals; Aspartic Acid; Brain Ischemia; Cats; Female; Male; Models, Cardiovascular; N-Methylaspartate; Phencyclidine; Piperidines; Rats; Rats, Inbred F344; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Vasoconstriction | 1988 |
Excitatory aminoacid antagonists provide a therapeutic approach to neurological disorders.
Topics: Adult; Amino Acids; Animals; Aspartic Acid; Brain Diseases; Brain Ischemia; Glutamates; Humans; Hypoxia, Brain; Infant; N-Methylaspartate; Nerve Degeneration; Neurotransmitter Agents; Quinolinic Acids; Receptors, Amino Acid; Receptors, Cell Surface; Seizures | 1985 |
Focal cerebral ischaemia in the cat: treatment with the glutamate antagonist MK-801 after induction of ischaemia.
Topics: Animals; Anticonvulsants; Aspartic Acid; Brain Ischemia; Cats; Dibenzocycloheptenes; Disease Models, Animal; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; N-Methylaspartate | 1988 |
Selective sparing of NADPH-diaphorase neurons in neonatal hypoxia-ischemia.
Topics: Animals; Animals, Newborn; Aspartic Acid; Brain Ischemia; Cerebral Cortex; Corpus Striatum; Hypoxia; N-Methylaspartate; NADH, NADPH Oxidoreductases; NADPH Dehydrogenase; Neurons; Neuropeptide Y; Rats; Rats, Inbred Strains; Somatostatin | 1988 |
Quantitative autoradiography of [3H]-MK-801 binding sites in mammalian brain.
Topics: Animals; Aspartic Acid; Autoradiography; Binding Sites; Brain; Brain Ischemia; Densitometry; Dibenzocycloheptenes; Dizocilpine Maleate; Gerbillinae; Glutamates; In Vitro Techniques; Muscle, Smooth, Vascular; N-Methylaspartate; Rats; Rats, Inbred Strains; Synaptic Membranes | 1988 |
Delayed treatment with dextromethorphan and dextrorphan reduces cerebral damage after transient focal ischemia.
Topics: Animals; Aspartic Acid; Brain Ischemia; Dextromethorphan; Dextrorphan; Levorphanol; Male; Morphinans; N-Methylaspartate; Rabbits | 1988 |