Compounds > n-methylaspartate
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n-methylaspartate and Bipolar Disorder

n-methylaspartate has been researched along with Bipolar Disorder in 12 studies

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (8.33)18.2507
2000's5 (41.67)29.6817
2010's6 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bey, AL; Cao, X; Ding, JD; Duffney, LJ; Ji, RR; Jiang, YH; Kim, YH; Pappas, AL; Phillips, SM; Porkka, F; Rodriguiz, RM; Rossi, M; Wang, X; Weinberg, RJ; Wetsel, WC; Yan, H; Yin, HH1
Luckenbaugh, DA; Lukkahati, N; Machado-Vieira, R; Niciu, MJ; Nugent, AC; Ortiz, R; Saligan, LN; Zarate, CA1
Machado-Vieira, R; Zarate, CA1
Brutsche, NE; Diazgranados, N; Ibrahim, L; Kammerer, WA; Khalife, S; Kronstein, P; Luckenbaugh, DA; Machado-Vieira, R; Manji, HK; Newberg, A; Quezado, Z; Salvadore, G; Zarate, CA1
Du, T; Hertz, L; Li, B; Peng, L; Wang, F1
Deng, S; Edbauer, D; Elsworth, JD; Kenny, PJ; Kleiman, RJ; Lanz, TA; Lawrence, MS; Miller, BH; Roth, RH; Strathmann, J; Wahlestedt, C; Willoughby, D; Xi, L; Zeier, Z1
Bown, CD; Wang, JF; Young, LT1
Gourevitch, R1
Coyle, JT; Frye, MA; Huggins, T; Post, RM; Tsai, GE1
Bazinet, RP; Ertley, RN; Lee, HJ; Rao, JS; Rapoport, SI1
Deakin, JF; Guimarães, FS; Oliveira, RM1
Bogerts, B; Böker, H; Danos, P; Lins, H; Northoff, G1

Reviews

1 review(s) available for n-methylaspartate and Bipolar Disorder

ArticleYear
Does conventional anti-bipolar and antidepressant drug therapy reduce NMDA-mediated neuronal excitation by downregulating astrocytic GluK2 function?
    Pharmacology, biochemistry, and behavior, 2012, Volume: 100, Issue:4

    Topics: Antidepressive Agents; Astrocytes; Bipolar Disorder; Down-Regulation; GluK2 Kainate Receptor; Humans; N-Methylaspartate; Neurons; Receptors, Kainic Acid

2012

Trials

2 trial(s) available for n-methylaspartate and Bipolar Disorder

ArticleYear
Shank3 as a potential biomarker of antidepressant response to ketamine and its neural correlates in bipolar depression.
    Journal of affective disorders, 2015, Feb-01, Volume: 172

    Topics: Adult; Aged; Amygdala; Antidepressive Agents; Biomarkers; Bipolar Disorder; Double-Blind Method; Female; Humans; Ketamine; Male; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Treatment Outcome

2015
A randomized add-on trial of an N-methyl-D-aspartate antagonist in treatment-resistant bipolar depression.
    Archives of general psychiatry, 2010, Volume: 67, Issue:8

    Topics: Adolescent; Adult; Aged; Bipolar Disorder; Diagnostic and Statistical Manual of Mental Disorders; Double-Blind Method; Drug Resistance; Drug Therapy, Combination; Excitatory Amino Acid Antagonists; Female; Humans; Ketamine; Lithium Compounds; Male; Middle Aged; N-Methylaspartate; Placebos; Psychiatric Status Rating Scales; Treatment Outcome; Valproic Acid

2010

Other Studies

9 other study(ies) available for n-methylaspartate and Bipolar Disorder

ArticleYear
Deficiency of Shank2 causes mania-like behavior that responds to mood stabilizers.
    JCI insight, 2017, 10-19, Volume: 2, Issue:20

    Topics: Amphetamine; Anhedonia; Animals; Antimanic Agents; Behavior, Animal; Bipolar Disorder; Central Nervous System Stimulants; Chronobiology Disorders; Cognitive Dysfunction; Female; Hippocampus; Lithium Compounds; Male; Mice; Mice, Knockout; Motor Activity; N-Methylaspartate; Nerve Tissue Proteins; Phenotype; Prosencephalon; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Social Behavior Disorders; Synapses

2017
GSK-3: A key regulatory target for ketamine's rapid antidepressant effects mediated by enhanced AMPA to NMDA throughput.
    Bipolar disorders, 2016, Volume: 18, Issue:8

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Antidepressive Agents; Bipolar Disorder; Glycogen Synthase Kinase 3; Humans; Ketamine; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate

2016
MicroRNA-132 dysregulation in schizophrenia has implications for both neurodevelopment and adult brain function.
    Proceedings of the National Academy of Sciences of the United States of America, 2012, Feb-21, Volume: 109, Issue:8

    Topics: Adult; Animals; Antipsychotic Agents; Bipolar Disorder; Brain; Cerebral Cortex; Databases, Genetic; Demography; Disease Models, Animal; DNA (Cytosine-5-)-Methyltransferases; DNA Methyltransferase 3A; GATA2 Transcription Factor; Gene Expression Regulation; HEK293 Cells; Humans; Mice; MicroRNAs; Muscle Proteins; N-Methylaspartate; Oligonucleotide Array Sequence Analysis; Open Reading Frames; Polymerase Chain Reaction; Rats; Receptors, N-Methyl-D-Aspartate; Reproducibility of Results; Schizophrenia; Signal Transduction

2012
Attenuation of N-methyl-D-aspartate-mediated cytoplasmic vacuolization in primary rat hippocampal neurons by mood stabilizers.
    Neuroscience, 2003, Volume: 117, Issue:4

    Topics: Animals; Antimanic Agents; Bipolar Disorder; Carbamazepine; Cell Survival; Cells, Cultured; Cytoplasm; Drug Interactions; Fetus; Glial Fibrillary Acidic Protein; Hippocampus; Lithium; Microscopy, Electron; N-Methylaspartate; Nerve Degeneration; Neurons; Neuroprotective Agents; Phosphopyruvate Hydratase; Rats; Treatment Outcome; Vacuoles; Valproic Acid

2003
[Neurobiological aspects of bipolar disorder].
    L'Encephale, 2005, Volume: 31, Issue:Pt 2

    Topics: Amygdala; Bipolar Disorder; Brain-Derived Neurotrophic Factor; Cognition Disorders; Diagnosis, Differential; Hippocampus; Humans; N-Methylaspartate; Neuropsychological Tests; Prefrontal Cortex; Psychotic Disorders; Schizophrenia

2005
Low cerebrospinal fluid glutamate and glycine in refractory affective disorder.
    Biological psychiatry, 2007, Jan-15, Volume: 61, Issue:2

    Topics: Adult; Anticonvulsants; Antidepressive Agents; Antimanic Agents; Aspartic Acid; Bipolar Disorder; Chromatography, High Pressure Liquid; Depressive Disorder, Major; Drug Resistance; Electroconvulsive Therapy; Female; Glutamic Acid; Glycine; Humans; Male; Middle Aged; N-Methylaspartate; Statistics as Topic

2007
Chronic NMDA administration to rats up-regulates frontal cortex cytosolic phospholipase A2 and its transcription factor, activator protein-2.
    Journal of neurochemistry, 2007, Volume: 102, Issue:6

    Topics: Animals; Antimanic Agents; Arachidonic Acid; Bipolar Disorder; DNA-Binding Proteins; Drug Administration Schedule; Excitatory Amino Acid Agonists; Frontal Lobe; Group IV Phospholipases A2; Male; N-Methylaspartate; Phospholipases A; Phospholipases A2; Phosphorylation; Protein Subunits; Rats; Rats, Inbred F344; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Subcellular Fractions; Transcription Factor AP-2; Up-Regulation

2007
Expression of neuronal nitric oxide synthase in the hippocampal formation in affective disorders.
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2008, Volume: 41, Issue:4

    Topics: Adult; Bipolar Disorder; Case-Control Studies; Depressive Disorder, Major; Female; Hippocampus; Humans; Immunohistochemistry; Male; Middle Aged; N-Methylaspartate; Nitric Oxide Synthase Type I; Schizophrenia; Signal Transduction

2008
Therapeutic efficacy of N-methyl D-aspartate antagonist amantadine in febrile catatonia.
    Journal of clinical psychopharmacology, 1999, Volume: 19, Issue:5

    Topics: Adult; Amantadine; Bipolar Disorder; Catatonia; Dopamine Agents; Excitatory Amino Acid Agonists; Fever; Humans; Male; N-Methylaspartate; Psychotic Disorders

1999