n-methylaspartate has been researched along with Aging in 217 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (6.45) | 18.7374 |
| 1990's | 113 (52.07) | 18.2507 |
| 2000's | 56 (25.81) | 29.6817 |
| 2010's | 33 (15.21) | 24.3611 |
| 2020's | 1 (0.46) | 2.80 |
| Authors | Studies |
|---|---|
| Barger, SW; Wu, S; Zhang, H; Zhou, J | 1 |
| Bischofberger, J; Heigele, S; Li, L; Schmidt-Salzmann, C; Sultan, S; Toni, N | 1 |
| Cho, SJ; Lovinger, DM; N'Gouemo, P | 1 |
| Atkinson, LA; Biello, SM; Bonsall, DR; Harrington, ME; Lall, GS; Molyneux, PC | 1 |
| Carvajal, FJ; Cerpa, W; Minniti, AN; Mira, RG; Rovegno, M | 1 |
| Evans, CE; Freeman, TJ; Good, MA; Hvoslef-Eide, M; Kidd, EJ; Thomas, RS | 1 |
| Fujita, T; Jiang, CY; Kumamoto, E; Liu, T; Luo, SW | 1 |
| Mattson, MP; Wang, Y | 1 |
| Huang, YJ; Lane, HY; Lin, CH; Lin, CJ; Tsai, GE | 1 |
| Etgen, AM; Neal-Perry, G; Shu, J; Sun, Y; Yao, D | 1 |
| Han, SH | 1 |
| Borsello, T; Calabresi, P; Costa, C; de Iure, A; Di Filippo, M; Ghiglieri, V; Sclip, A; Tantucci, M; Tozzi, A | 1 |
| Beckhauser, TF; De Pasquale, R; Giorgetti Britto, LR; Hernandes, MS | 1 |
| Fiedorowicz, M; Grieb, P; Rejdak, R; Schuettauf, F; Thaler, S; Wozniak, M | 1 |
| Carvalho, RV; da Silva Ferreira, F; Fernandes, C; Heimfarth, L; Pessoa-Pureur, R; Pierozan, P | 1 |
| Ahmed, T; Baliyan, S; Balschun, D; Dotti, CG; Martin, MG; Martín-Segura, A; Palomer, E; Venero, C | 1 |
| Acarin, L; Campuzano, O; Castellano, B; Castillo-Ruiz, MM; Gonzalez, B | 4 |
| Kashiyae, Y; Kawashima, H; Kiso, Y; Kontani, M; Kudo, Y; Sakakibara, M | 1 |
| Toyoda, H; Wang, YK; Zhao, MG; Zhuo, M | 1 |
| Albright, MJ; Chang, PS; Lu, HC; Quairiaux, C; Sanchez, DE; She, WC; Wang, YC; Welker, E | 1 |
| Agin, V; Ali, C; Castel, H; Dauphinot, L; Hommet, Y; Jullienne, A; Macrez, R; Maubert, E; Montaner, J; Munuera, J; Plawinski, L; Potier, MC; Roussel, BD; Vivien, D; Yepes, M | 1 |
| Cengiz, N; Guneser, R; Him, A; Oztürk, G | 1 |
| Alexander, KS; Brooks, JM; Bruno, JP; Sarter, M | 1 |
| Porkka-Heiskanen, T; Rytkönen, KM; Wigren, HK | 1 |
| Abdalla, FM; Bertoncini, CR; Fernandes, MJ; Hsu, YT; Lopes, GS; Porto, CS; Smaili, SS; Ureshino, RP | 1 |
| Dierckx, RA; Elsinga, PH; Ishiwata, K; Luiten, PG; Nijholt, IM; Ramakrishnan, NK; Rybczynska, AA; van Waarde, A | 1 |
| Izumi, Y; Zorumski, CF | 1 |
| Dotti, CG; Ledesma, MD; Sodero, AO; Weissmann, C | 1 |
| Becker, KG; Gleichmann, M; Kobilo, T; Markesbery, WR; Mattson, MP; Mughal, MR; Pazin, MJ; Troncoso, JC; van Praag, H; Wood, WH; Zhang, Y; Zonderman, AB | 1 |
| Chen, Y; Feng, C; Hu, C; Xiao, L | 1 |
| Ahmed, T; Balschun, D; D'Hooge, R; Sabanov, V | 1 |
| André, VM; Cepeda, C; Cummings, DM; Ehrlich, ME; Kim, SH; Levine, MS; Thomas, CA | 1 |
| Agostinho, PM; Canas, PM; Costenla, AR; Cunha, RA; de Mendonça, A; Diógenes, MJ; Maroco, J; Nogueira, C; Ribeiro, JA; Rodrigues, RJ | 1 |
| Chan, MH; Chen, HH; Lin, YR | 1 |
| Huh, Y; Lee, LH; Lee, SY; Shim, HJ; Yeo, SG | 1 |
| Blanc, T; Dahmani, S; Jegou-Colleter, S; Laudenbach, V; Marret, S; Tourrel, F | 1 |
| Benavides, AD; Caccamo, A; Javors, MA; Kraig, E; Majumder, S; Medina, DX; Oddo, S; Richardson, A; Strong, R | 1 |
| Huppé-Gourgues, F; O'Donnell, P | 1 |
| Abrahám, IM; Kőszegi, Z | 1 |
| Caspary, DM; Llano, DA; Turner, J | 1 |
| Haugvicová, R; Kubová, H; Mares, P | 1 |
| Armstead, WM | 3 |
| Amamoto, T; Ando, S; Fujiwara, M; Nakanishi, H; Okada, M; Urae, R; Yazawa, K | 1 |
| Bickler, PE; Fahlman, CS; Taylor, DM | 1 |
| Buchanan, AK; Nordell, VL; Scarborough, MM; Sohrabji, F | 1 |
| Kuehl-Kovarik, MC; Magnusson, KR; Partin, KM | 1 |
| Fernandez-Salguero, PM; Merino, JM; Mulero-Navarro, S; Pozo-Guisado, E; Santiago-Josefat, B | 1 |
| Egawa-Tsuzuki, T; Faigle, R; Funa, K; Ishii, Y; Ohno, M; Sasahara, M; Takeuchi, Y; Tanaka, N; Uramoto, H | 1 |
| Bicker, G; Paquet-Durand, F | 1 |
| Daoust, M; Naassila, M; Pierrefiche, O | 1 |
| Fukuda, S; Hisatsune, T; Imura, T; Kanatani, S; Miyamoto, Y | 1 |
| Akagi, T; Akita, J; Honda, Y; Kageyama, R; Mandai, M; Ooto, S; Takahashi, M | 1 |
| Mora, F; Segovia, G | 1 |
| Fu, Z; Logan, SM; Vicini, S | 1 |
| Bowen, RL; Gregory, CW | 1 |
| Andreasson, K; Breyer, R; Liu, D; Mattson, MP; Wu, L | 1 |
| Majewska, A; Oray, S; Sur, M | 1 |
| Curado, MR; Linden, R; Martins, RA; Police, AI; Silveira, MS | 1 |
| Lin, AM | 1 |
| Chida, Y; Kubo, C; Mori, J; Sudo, N | 1 |
| Roubos, EW; van de Bovenkamp-Janssen, MC; van der Kloet, JC; van Luijtelaar, G | 1 |
| Baquer, NZ; Cowsik, SM; Mantha, AK; Moorthy, K | 1 |
| Danias, J; Filippopoulos, T; Mittag, T; Reichstein, D; Ren, L | 1 |
| Cauli, O; Felipo, V; Montoliu, C; Piedrafita, B | 1 |
| Brewer, LD; Garcia-Ramos, G; Kraner, S; Landfield, PW; Porter, NM; Rogers, JT; Staton, J; Thibault, O; Thibault, V | 1 |
| Kellaway, L; Lehohla, M; Russell, VA | 1 |
| Harms, A; Johnson, AB; Lewis, DK; Sohrabji, F; Stohlgren, S | 1 |
| Hambley, JW; Rogers, LJ | 1 |
| Oja, SS; Saransaari, P | 4 |
| Raiteri, M; Vallebuona, F | 1 |
| Horimoto, N; Kawamoto, I; Nabekura, J; Ogawa, T | 1 |
| Kalb, RG; Maier, DL; Stelzner, DJ | 1 |
| Rocha, M; Sur, M | 1 |
| Darby-King, A; McLean, JH; Neuman, RS; Paterno, G; Rahman, S; Reynolds, JN | 1 |
| Felipo, V; Grisolía, S; Marcaida, G; Miñana, MD | 1 |
| Ali, SF; Bowyer, JF; Holson, RR; Newport, GD; Slikker, W | 1 |
| Abdul-Razzak, R; Bagust, J; Kerkut, GA | 1 |
| Albuquerque, EX; Alkondon, M; Ishihara, K; Montes, JG | 1 |
| Fortuna, S; Michalek, H; Pintor, A | 1 |
| Aronica, E; Balázs, R; Condorelli, DF; Dell'Albani, P; Hack, N; Nicoletti, F | 1 |
| Chang, CM; Chang, LW; Wei, JW | 1 |
| Cabrera, RJ; Donoso, AO; Navarro, CE | 1 |
| Beal, MF; Ferrante, RJ; Henshaw, DR; Jenkins, BG; Kowall, NW; Rosen, BR; Schulz, JB | 1 |
| Faraci, FM; Heistad, DD | 1 |
| Müller, WE; Scheuer, K; Stoll, S | 1 |
| D'Angelo, E; Rossi, P; Taglietti, V | 1 |
| Garaschuk, O; Kovalchuk, Yu; Krishtal, O | 1 |
| Chalecka-Franaszek, E; Fortuna, S; Michalek, H; Nalepa, I; Pintor, A; Vetulani, J | 1 |
| Davies, JA; Ellis, Y; Rowley, HL | 1 |
| Burtrum, D; Silverstein, FS | 1 |
| Gibson, MJ; Miller, GM | 1 |
| Brooks, WJ; LeBoutillier, JC; Petit, TL | 1 |
| Denavit-Saubié, M; Ghilini, G; Salès, N | 1 |
| Andreasson, KI; Barnes, CA; Kaufmann, WE; Worley, PF; Yamagata, K | 1 |
| MacDonald, MC; Robertson, HA; Wilkinson, M | 2 |
| Castrén, E; Cooper, J; da Penha Berzaghi, M; Lindholm, D; Sofroniew, M; Thoenen, H; Zafra, F | 1 |
| Fedele, E; Pittaluga, A; Raiteri, M; Risiglione, C | 1 |
| Cotman, CW; Magnusson, KR | 1 |
| Gay, VL; Mikuma, N; Plant, TM | 1 |
| Mareś, P; Velísek, L | 3 |
| Douma, BR; Luiten, PG; Nyakas, C; Van der Zee, EA | 1 |
| Broide, RS; Leslie, FM; Robertson, RT | 1 |
| Armstrong, JD; Barb, CR; Campbell, RM; Cox, NM | 1 |
| Brann, DW; Mahesh, VB; Zamorano, PL; Zuo, Z | 1 |
| Mills, LR | 1 |
| Clementi, E; Meldolesi, J; Melino, G; Racchetti, G | 1 |
| Chuang, DM; Hirano, A; Ishitani, R; Katsube, N; Saunders, P; Sunaga, K | 1 |
| Gadamski, R; Hagberg, H; Lazarewicz, JW; Puka-Sundvall, M; Sandberg, M | 1 |
| Gribkoff, VK; Molinoff, PB; Zhong, J | 1 |
| Cepeda, C; Levine, MS; Li, Z | 1 |
| Bakker, R; Douma, BR; Luiten, PG; Nyakas, C; Stuiver, BT | 1 |
| Bosy, TZ; Luo, J; Wang, Y; Wolfe, BB; Yasuda, RP | 1 |
| Fleischer-Lambropoulos, E; Geladopoulos, T; Kazazoglou, T; Kentroti, S; Stefanis, C; Vernadakis, A | 1 |
| Bizon, JL; Gallagher, M; Nicolle, MM | 1 |
| Aguilar, E; Aguilar, R; González, D; Pinilla, L; Tena-Sempere, M | 2 |
| Cooper, JD; Sofroniew, MV | 1 |
| Ikonomidou, C; Turski, L | 1 |
| Arias, P; Carbone, S; Feleder, C; Moguilevsky, JA; Rodríguez, M; Scacchi, P; Szwarcfarb, B | 1 |
| Aleppo, G; Canonico, PL; Scapagnini, U; Sortino, MA | 1 |
| Dugar, A; Lakoski, JM | 1 |
| Jean, A; Tell, F; Vincent, A | 1 |
| Haberecht, MF; Lo, GJ; Mitchell, CK; Redburn, DA | 1 |
| Gallagher, M; Gill, TM; Nicolle, MM; Shivers, A | 1 |
| Folbergrová, J; Haugvicová, R; Lisý, V; Stastný, F | 1 |
| Iizuka, M; Kiehn, O; Kudo, N | 1 |
| Benz, AM; Izumi, Y; Kirby-Sharkey, CO; Labruyere, J; Olney, JW; Price, MT; Wozniak, DF; Zorumski, CF | 1 |
| Cepeda, C; Levine, MS | 1 |
| Ackerman, AE; Clemens, LG; Lange, GM | 1 |
| Bonavera, JJ; Lue, YH; Sinha Hakim, AP; Swerdloff, RS; Wang, C | 1 |
| Bickler, PE; Hansen, BM | 1 |
| Guidetti, P; Poeggeler, B; Rassoulpour, A; Schwarcz, R; Wu, HQ | 1 |
| Binns, KE; Salt, TE | 1 |
| Beard, AP; Chandolia, RK; Honaramooz, A; Rawlings, NC | 1 |
| Bolton, SJ; Perry, VH | 1 |
| Aguilar, E; Dieguez, C; Gonzalez, L; Pinilla, L; Tena-Sempere, M | 1 |
| Mienville, JM; Pesold, C | 1 |
| Angenstein, F; Buchner, K; Staak, S | 1 |
| Lima, R; Titmus, MJ; Tsai, HJ; Udin, SB | 1 |
| Imamura, K; Kaub, PA; Kobayashi, M; Nakadate, K; Watanabe, Y | 1 |
| Albuquerque, C; Jackson, AC; Lee, CJ; MacDermott, AB | 1 |
| Bourguignon, JP; Gerard, A; Lebrethon, MC; Lemaitre, M; Purnelle, G; Vandersmissen, E; Wilk, S; Yamanaka, C | 1 |
| Descombes, S; Psarropoulou, C | 1 |
| Anderson, KJ; Burchfield, DJ; Mason, KL; McGraw, TS; Sapper, MS; Theophilopoulos, DT | 1 |
| Aamodt, SM; Colonnese, MT; Constantine-Paton, M; Shi, J; Veras, W | 1 |
| Ceresoli-Borroni, G; Guidetti, P; Hodgkins, PS; Poeggeler, B; Rassoulpour, A; Schwarcz, R; Wu, HQ | 1 |
| Livingston, FS; Mooney, R; White, SA | 1 |
| Domenici, MR; Pèzzola, A; Pintor, A; Popoli, P; Potenza, RL; Reggio, R; Tiburzi, F | 1 |
| Ebling, FJ; Ford, H | 1 |
| Gore, AC; Morrison, JH; Oung, T; Yeung, G | 1 |
| Bindokas, VP; Marks, JD; Zhang, XM | 1 |
| Billard, JM; Dutar, P; Poindessous-Jazat, F; Potier, B | 1 |
| Bahr, BA; Hoffman, KB; Lynch, G; Munirathinam, S; Murray, BA | 1 |
| Darling, S; Huber, J; Park, K; Soliman, KF | 1 |
| Jeśko, H; Strosznajder, JB; Strosznajder, RP | 1 |
| Guo, Y; Sánchez, C; Udin, SB | 1 |
| Barbanel, G; Cambonie, G; Kamenka, JM | 1 |
| Aamodt, SM; Constantine-Paton, M; Shi, J; Townsend, M | 1 |
| Brewer, GJ; Cady, C; Evans, MS | 1 |
| Gibb, AJ; Green, GM | 1 |
| Acarin, L; Castellano, B; González, B; Paris, J | 1 |
| Bringmann, A; Pannicke, T; Reichenbach, A | 1 |
| Holmes, GL; Stafstrom, CE | 1 |
| Dudek, FE; Peacock, WJ; Wuarin, JP | 1 |
| Czepita, D; Daw, N; Fox, K; Sato, H | 1 |
| Lanius, RA; Shaw, C | 1 |
| Martin, D; McNamara, JO; Nadler, JV | 1 |
| Johnston, MV; McDonald, JW; Trescher, WH | 1 |
| Akaike, N; Ebihara, S; Harata, N | 1 |
| Fujiwara, M; Iwasaki, K; Mine, K; Okada, M; Urae, A | 1 |
| Cavalheiro, EA; de Feo, MR; Mecarelli, O; Ricci, G | 1 |
| Kulkarni, SK; Sharma, AC | 1 |
| Pisana, FM; Sica, AL; Siddiqi, ZA | 1 |
| Kitamura, Y; Nomura, Y; Zhao, XH | 1 |
| Boksa, P; Chaudieu, I; Mount, H; Quirion, R | 1 |
| Morita, Y; Nishimura, S; Sorimachi, M | 1 |
| Barish, ME; Mansdorf, NB | 1 |
| Blanton, MG; Kriegstein, AR; LoTurco, JJ | 1 |
| Brooks, WJ; LeBoutillier, JC; Lo, R; Petit, TL | 1 |
| Baba, A; Etoh, S; Iwata, H | 1 |
| Buchwald, NA; Cepeda, C; Levine, MS; Peacock, W | 1 |
| Doudou, N; Kito, S; Miyoshi, R; Nomoto, T | 1 |
| Ben-Ari, Y; Roisin-Lallemand, MP; Tremblay, E | 1 |
| Hunt, A; Patel, AJ; Sanfeliu, C | 1 |
| Banczerowski-Pelyhe, I; Tarnawa, I; Világi, I | 1 |
| Acs, Z; Lónárt, G; Makara, GB | 1 |
| Ben-Ari, Y; Cherubini, E; Corradetti, R; Gaiarsa, JL | 1 |
| Cotman, CW; Krause, JD; Nangel-Taylor, K; Palmer, E; Roxas, A | 1 |
| Ikeda, H; Kay, CD; Robbins, J | 1 |
| Bourguignon, JP; Franchimont, P; Gerard, A; Mathieu, A; Mathieu, J | 1 |
| Gamble, AY; Johnson, BG; Ornstein, PL; Salhoff, CR; Schoepp, DD | 1 |
| Nomura, Y; Zhao, XH | 1 |
| Baskys, A; Carlen, PL; Reynolds, JN | 1 |
| Finch, CE; Kohama, SG; May, PC | 1 |
| Ben-Ari, Y; Cherubini, E; Krnjević, K | 2 |
| Ben-Ari, Y; Represa, A; Tremblay, E | 1 |
| Guiramand, J; Recasens, M; Sassetti, I | 1 |
| Bear, MF; Dudek, SM | 1 |
| Ben-Ari, Y; Charriaut-Marlangue, C; Represa, A; Roisin, MP; Tremblay, E | 1 |
| Garthwaite, G; Garthwaite, J | 1 |
| Johnston, MV; McDonald, JW; Silverstein, FS | 1 |
| Hamon, B; Heinemann, U | 1 |
| Bell, RD; Cicero, TJ; Meyer, ER | 1 |
| Garthwaite, G; Garthwaite, J; Yamini, B | 1 |
| Brady, RJ; Swann, JW | 1 |
9 review(s) available for n-methylaspartate and Aging
| Article | Year |
|---|---|
Serine Racemase Expression Differentiates Aging from Alzheimer's Brain.
Topics: Aging; Alzheimer Disease; Brain; Humans; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Serine | 2022 |
NMDA neurotransmission dysfunction in mild cognitive impairment and Alzheimer's disease.
Topics: Aged; Aging; Alzheimer Disease; Animals; Brain; Cognitive Dysfunction; Disease Models, Animal; Drug Design; Humans; N-Methylaspartate; Neuronal Plasticity; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 2014 |
The cholinergic system, sigma-1 receptors and cognition.
Topics: Acetylcholine; Aging; Animals; Brain; Calcium; Cell Differentiation; Cholinergic Fibers; Cognition; Disease Models, Animal; Glutamic Acid; Humans; N-Methylaspartate; Neurodegenerative Diseases; Neuronal Plasticity; Neurons; Psychotropic Drugs; Receptors, sigma; Sigma-1 Receptor | 2011 |
[Neurological consequences after long-term sedation in the ICU].
Topics: Aging; Anesthetics, General; Animals; Cesarean Section; Conscious Sedation; Critical Care; Excitatory Amino Acid Agonists; Female; Fetal Alcohol Spectrum Disorders; gamma-Aminobutyric Acid; Humans; Hypnotics and Sedatives; Infant, Newborn; Infant, Premature; Intensive Care Units; N-Methylaspartate; Nervous System Diseases; Neurotoxicity Syndromes; Pregnancy; Primates; Synaptic Transmission; Teratogens | 2012 |
Novel therapeutic strategies for Alzheimer's disease based on the forgotten reproductive hormones.
Topics: Aging; Alzheimer Disease; Enzyme Inhibitors; Female; Gonadotropin-Releasing Hormone; Gonadotropins; Humans; Luteinizing Hormone; Male; N-Methylaspartate | 2005 |
Glutamatergic treatment strategies for age-related memory disorders.
Topics: Acetamides; Aging; Animals; Cognition; Cycloserine; Glutamic Acid; Humans; Memory Disorders; N-Methylaspartate; Nootropic Agents; Receptors, N-Methyl-D-Aspartate | 1994 |
The sodium-calcium exchanger and glutamate-induced calcium loads in aged hippocampal neurons in vitro.
Topics: Aging; Animals; Calcium; Carrier Proteins; Cells, Cultured; Glutamic Acid; Hippocampus; N-Methylaspartate; Neurons; Rats; Sodium; Sodium-Calcium Exchanger | 1996 |
Neurodegenerative disorders: clues from glutamate and energy metabolism.
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Damage, Chronic; Brain Injuries; Brain Ischemia; Energy Metabolism; Excitatory Amino Acid Antagonists; Glutamates; Humans; N-Methylaspartate; Nerve Degeneration; Nervous System Diseases; Neurotoxins | 1996 |
Infantile spasms: criteria for an animal model.
Topics: Adrenocorticotropic Hormone; Aging; Anticonvulsants; Corticotropin-Releasing Hormone; Disease Models, Animal; Electroencephalography; Humans; Infant; N-Methylaspartate; Sleep Stages; Spasms, Infantile; Wakefulness | 2002 |
1 trial(s) available for n-methylaspartate and Aging
| Article | Year |
|---|---|
Aspartate and glutamate modulation of growth hormone secretion in the pig: possible site of action.
Topics: 2-Amino-5-phosphonovalerate; Aging; Animals; Aspartic Acid; Body Weight; Cells, Cultured; Dose-Response Relationship, Drug; Female; Glutamic Acid; Growth Hormone; Growth Hormone-Releasing Hormone; N-Methylaspartate; Ovariectomy; Pituitary Gland, Anterior; Serum Albumin; Swine | 1996 |
207 other study(ies) available for n-methylaspartate and Aging
| Article | Year |
|---|---|
Silent synapses generate sparse and orthogonal action potential firing in adult-born hippocampal granule cells.
Topics: Action Potentials; Aging; Animals; Cytoplasmic Granules; Dendrites; Excitatory Postsynaptic Potentials; Glutamates; Hippocampus; Male; Mice, Inbred C57BL; N-Methylaspartate; Neurogenesis; Presynaptic Terminals; Receptors, N-Methyl-D-Aspartate; Synapses; Time Factors | 2017 |
Prenatal alcohol exposure enhances the susceptibility to NMDA-induced generalized tonic-clonic seizures in developing rats.
Topics: Aging; Animals; Binge Drinking; Disease Models, Animal; Disease Susceptibility; Female; Fetal Alcohol Spectrum Disorders; Male; N-Methylaspartate; Rats, Sprague-Dawley; Seizures; Sex Characteristics | 2017 |
Alterations in glutamatergic signaling contribute to the decline of circadian photoentrainment in aged mice.
Topics: Aging; Animals; Chronobiology Disorders; Circadian Rhythm; Eye; Light; Male; Mice, Inbred C57BL; N-Methylaspartate; Signal Transduction; Suprachiasmatic Nucleus; Visual Pathways | 2018 |
Age-related NMDA signaling alterations in SOD2 deficient mice.
Topics: Age Factors; Aging; Animals; Behavior, Animal; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Models, Animal; N-Methylaspartate; Neurodegenerative Diseases; Neuronal Plasticity; Neurons; Oxidative Stress; Phosphorylation; Protein Tyrosine Phosphatases, Non-Receptor; PTEN Phosphohydrolase; Reactive Oxygen Species; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Superoxide Dismutase; Synapses | 2018 |
Selective reduction of APP-BACE1 activity improves memory via NMDA-NR2B receptor-mediated mechanisms in aged PDAPP mice.
Topics: Aging; Alzheimer Disease; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Male; Memory; Mice, Transgenic; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate | 2019 |
Enhancement by interleukin-1β of AMPA and NMDA receptor-mediated currents in adult rat spinal superficial dorsal horn neurons.
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Humans; In Vitro Techniques; Interleukin-1beta; Ion Channel Gating; Male; Minocycline; N-Methylaspartate; Neuroglia; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Interleukin-1; Receptors, N-Methyl-D-Aspartate; Substantia Gelatinosa; Tetrodotoxin | 2013 |
L-type Ca2+ currents at CA1 synapses, but not CA3 or dentate granule neuron synapses, are increased in 3xTgAD mice in an age-dependent manner.
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Alzheimer Disease; Amyloid beta-Peptides; Animals; CA1 Region, Hippocampal; CA3 Region, Hippocampal; Calcium Channels, L-Type; Cells, Cultured; Cognition Disorders; Dentate Gyrus; Mice; Mice, Inbred C57BL; Mice, Transgenic; N-Methylaspartate; Patch-Clamp Techniques; Phosphorylation; Potassium Channels, Voltage-Gated; Synapses; tau Proteins | 2014 |
Insulin-like growth factor-I regulates LH release by modulation of kisspeptin and NMDA-mediated neurotransmission in young and middle-aged female rats.
Topics: Aging; Animals; Female; Gene Expression Regulation, Developmental; Hypothalamo-Hypophyseal System; Hypothalamus; Infusions, Intraventricular; Insulin-Like Growth Factor I; Kisspeptins; Luteinizing Hormone; N-Methylaspartate; Nerve Tissue Proteins; Neuroendocrine Cells; Oligopeptides; Rats; Rats, Sprague-Dawley; Receptor, IGF Type 1; Receptors, G-Protein-Coupled; Receptors, Kisspeptin-1; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Synaptic Transmission | 2014 |
Increasing burden of Alzheimer's disease by aging.
Topics: Aging; Alzheimer Disease; Cost of Illness; Excitatory Amino Acid Agonists; Health Behavior; Humans; N-Methylaspartate; Risk Factors | 2014 |
Region- and age-dependent reductions of hippocampal long-term potentiation and NMDA to AMPA ratio in a genetic model of Alzheimer's disease.
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Cholinesterase Inhibitors; Disease Models, Animal; Hippocampus; Long-Term Potentiation; Mice, Transgenic; Molecular Targeted Therapy; Mutation; N-Methylaspartate; Neostigmine; Plaque, Amyloid | 2015 |
LTP and LTD in the visual cortex require the activation of NOX2.
Topics: Acetophenones; Aging; Animals; Antioxidants; Dizocilpine Maleate; Enzyme Activation; Excitatory Amino Acid Antagonists; Long-Term Potentiation; Long-Term Synaptic Depression; Male; Membrane Glycoproteins; Membrane Potentials; Mice; Mice, Knockout; N-Methylaspartate; NADPH Oxidase 2; NADPH Oxidases; Reactive Oxygen Species; Visual Cortex | 2014 |
Age-dependent neuroprotection of retinal ganglion cells by tempol-C8 acyl ester in a rat NMDA toxicity model.
Topics: Aging; Animals; Cyclic N-Oxides; Disease Models, Animal; Excitatory Amino Acid Agonists; N-Methylaspartate; Neuroprotective Agents; Rats; Retinal Ganglion Cells; Spin Labels | 2014 |
Acute Hyperammonemia Induces NMDA-Mediated Hypophosphorylation of Intermediate Filaments Through PP1 and PP2B in Cerebral Cortex of Young Rats.
Topics: Acetates; Aging; Ammonium Chloride; Animals; Astrocytes; Calcineurin; Calcium; Calcium Signaling; Cerebral Cortex; Disease Models, Animal; Hippocampus; Hyperammonemia; Intermediate Filaments; N-Methylaspartate; Neurons; Phosphorylation; Protein Phosphatase 1; Rats, Wistar; Time Factors; Tissue Culture Techniques | 2016 |
Aging Triggers a Repressive Chromatin State at Bdnf Promoters in Hippocampal Neurons.
Topics: Acetylation; Aging; Animals; Brain-Derived Neurotrophic Factor; Cholesterol; Chromatin; Cognition; Epigenesis, Genetic; Hippocampus; Histones; Long-Term Potentiation; Lysine; Methylation; Mice, Inbred C57BL; N-Methylaspartate; Neurons; Promoter Regions, Genetic; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Transcription, Genetic; Voriconazole | 2016 |
Distinct pattern of microglial response, cyclooxygenase-2, and inducible nitric oxide synthase expression in the aged rat brain after excitotoxic damage.
Topics: Aging; Animals; Brain; Cyclooxygenase 2; Excitatory Amino Acid Agonists; Fluorescent Antibody Technique; Immunohistochemistry; Male; Microglia; Microscopy, Confocal; N-Methylaspartate; Neurons; Neutrophils; Nitric Oxide Synthase Type II; Rats; Rats, Wistar | 2008 |
Increased levels of proinflammatory cytokines in the aged rat brain attenuate injury-induced cytokine response after excitotoxic damage.
Topics: Aging; Animals; Astrocytes; Brain; Brain Injuries; Cerebral Cortex; Corpus Striatum; Interleukin-1beta; Interleukin-6; Macrophages; Male; Microglia; N-Methylaspartate; Neurons; Rats; Rats, Wistar; Time Factors; Tumor Necrosis Factor-alpha | 2009 |
Arachidonic acid enhances intracellular calcium levels in dentate gyrus, but not CA1, in aged rat.
Topics: Aging; Animals; Arachidonic Acid; Calcium; Cell Membrane; Dentate Gyrus; Electric Stimulation; Excitatory Postsynaptic Potentials; Hippocampus; Homeostasis; Intracellular Space; Long-Term Potentiation; Male; N-Methylaspartate; Rats; Rats, Inbred F344; Receptors, N-Methyl-D-Aspartate | 2009 |
Enhanced synaptic long-term potentiation in the anterior cingulate cortex of adult wild mice as compared with that in laboratory mice.
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Gyrus Cinguli; Long-Term Potentiation; Mice; Mice, Inbred C57BL; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 2009 |
Roles of mGluR5 in synaptic function and plasticity of the mouse thalamocortical pathway.
Topics: Aging; Animals; Cerebral Cortex; In Vitro Techniques; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Neural Pathways; Neuronal Plasticity; Neurons; Patch-Clamp Techniques; Receptor, Metabotropic Glutamate 5; Receptors, AMPA; Receptors, Metabotropic Glutamate; Synapses; Synaptic Transmission; Thalamus; Touch Perception; Vibrissae | 2009 |
Age and albumin D site-binding protein control tissue plasminogen activator levels: neurotoxic impact.
Topics: Aged; Aged, 80 and over; Aging; Animals; Brain; Brain Ischemia; Cell Death; Disease Models, Animal; DNA-Binding Proteins; Female; Gene Knockdown Techniques; Humans; Magnetic Resonance Imaging; Mice; Mice, Inbred C57BL; Middle Aged; N-Methylaspartate; Neurons; Reverse Transcriptase Polymerase Chain Reaction; Tissue Plasminogen Activator; Transcription Factors | 2009 |
Glutamate responsiveness of medial vestibular nucleus neurons in aged rats.
Topics: Action Potentials; Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Glutamic Acid; In Vitro Techniques; Male; Microelectrodes; N-Methylaspartate; Neurons; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Vestibular Nuclei | 2010 |
Disruption of mesolimbic regulation of prefrontal cholinergic transmission in an animal model of schizophrenia and normalization by chronic clozapine treatment.
Topics: Acetylcholine; Aging; Amphetamine; Animals; Animals, Newborn; Clozapine; Disease Models, Animal; Hippocampus; Ibotenic Acid; Male; Microinjections; N-Methylaspartate; Neural Pathways; Nucleus Accumbens; Prefrontal Cortex; Rats; Rats, Wistar; Schizophrenia; Time Factors | 2009 |
Basal forebrain lactate release and promotion of cortical arousal during prolonged waking is attenuated in aging.
Topics: Age Factors; Aging; Analysis of Variance; Animals; Arousal; Cerebral Cortex; Chromatography, High Pressure Liquid; Electrochemical Techniques; Electroencephalography; Electromyography; Excitatory Amino Acid Agonists; Fourier Analysis; Lactic Acid; Male; Microdialysis; N-Methylaspartate; Rats; Rats, Wistar; Sleep; Sleep Deprivation; Spectrum Analysis; Time Factors; Wakefulness | 2009 |
Alterations in calcium signaling and a decrease in Bcl-2 expression: possible correlation with apoptosis in aged striatum.
Topics: Aging; Animals; Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Calcium; Corpus Striatum; Fluorescent Antibody Technique; Glutamic Acid; In Situ Nick-End Labeling; In Vitro Techniques; Mitochondria; N-Methylaspartate; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Wistar; Reactive Oxygen Species; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Time Factors | 2010 |
Neuroprotective effects of pyruvate following NMDA-mediated excitotoxic insults in hippocampal slices.
Topics: Adenosine Triphosphate; Aging; Animals; Brain Injuries; CA1 Region, Hippocampal; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glyceraldehyde-3-Phosphate Dehydrogenases; Hippocampus; In Vitro Techniques; N-Methylaspartate; Nerve Degeneration; Neurotoxins; Nitric Oxide; Pyruvic Acid; Rats; Receptors, N-Methyl-D-Aspartate; Synapses | 2010 |
Cellular stress from excitatory neurotransmission contributes to cholesterol loss in hippocampal neurons aging in vitro.
Topics: Acetophenones; Aging; Animals; Apoptosis; Biotinylation; Cell Death; Cholesterol; Cholesterol 24-Hydroxylase; DNA Fragmentation; Embryo, Mammalian; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Gene Expression Regulation; Hippocampus; Mice; Mice, Inbred C57BL; N-Methylaspartate; NADPH Oxidases; Neurons; Oxidative Stress; Protein Transport; Rats; Rats, Wistar; Reactive Oxygen Species; RNA, Messenger; Signal Transduction; Sodium Channel Blockers; Steroid Hydroxylases; Synaptic Transmission; Synaptosomes; Tetrodotoxin; Time Factors | 2011 |
Molecular changes in brain aging and Alzheimer's disease are mirrored in experimentally silenced cortical neuron networks.
Topics: Aging; Alzheimer Disease; Animals; Calcium Signaling; Cell Survival; Cells, Cultured; Cerebral Cortex; Electroshock; Energy Metabolism; Environment; Gene Expression; Humans; Interneurons; Lipid Metabolism; Mice; Mice, Inbred C57BL; N-Methylaspartate; Nerve Net; Neuronal Plasticity; Receptor, trkB; Synaptic Transmission | 2012 |
Switching of N-methyl-D-aspartate (NMDA) receptor-favorite intracellular signal pathways from ERK1/2 protein to p38 mitogen-activated protein kinase leads to developmental changes in NMDA neurotoxicity.
Topics: Aging; Animals; Calcium; Cell Differentiation; Embryo, Mammalian; Enzyme Activation; Hippocampus; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 3; N-Methylaspartate; Neurons; p38 Mitogen-Activated Protein Kinases; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2011 |
An N-methyl-D-aspartate-receptor dependent, late-phase long-term depression in middle-aged mice identifies no GluN2-subunit bias.
Topics: Aging; Animals; Calcium Channel Blockers; Diazonium Compounds; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Hippocampus; Long-Term Synaptic Depression; Mice; Mice, Inbred C57BL; N-Methylaspartate; Neurons; Nifedipine; Patch-Clamp Techniques; Pyridines; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate | 2011 |
Forebrain striatal-specific expression of mutant huntingtin protein in vivo induces cell-autonomous age-dependent alterations in sensitivity to excitotoxicity and mitochondrial function.
Topics: Aging; Animals; Corpus Striatum; Disease Models, Animal; Electron Transport Chain Complex Proteins; Electron Transport Complex II; Electrophysiology; Huntingtin Protein; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mitochondria; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Nuclear Proteins; Prosencephalon; Quinolinic Acid | 2011 |
Decreased myeloperoxidase expressing cells in the aged rat brain after excitotoxic damage.
Topics: Aging; Animals; Astrocytes; Corpus Striatum; Excitatory Amino Acid Agonists; Immunohistochemistry; Macrophages; Male; Microglia; N-Methylaspartate; Neurons; Neutrophil Infiltration; Peroxidase; Rats; Rats, Wistar; Time Factors | 2011 |
Enhanced role of adenosine A(2A) receptors in the modulation of LTP in the rat hippocampus upon ageing.
Topics: Adenosine; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Aging; Animals; Electrophysiology; Excitatory Postsynaptic Potentials; Glutamic Acid; Hippocampus; Long-Term Potentiation; Male; Memory Disorders; N-Methylaspartate; Neuronal Plasticity; Pyrimidines; Rats; Rats, Wistar; Receptor, Adenosine A1; Receptor, Adenosine A2A; Synaptic Transmission; Triazoles; Xanthines | 2011 |
Toluene exposure during brain growth spurt and adolescence produces differential effects on N-methyl-D-aspartate receptor-mediated currents in rat hippocampus.
Topics: Aging; Animals; CA1 Region, Hippocampal; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Hippocampus; In Vitro Techniques; Inhalant Abuse; Injections, Intraperitoneal; Male; N-Methylaspartate; Nerve Tissue Proteins; Neural Conduction; Neurons; Neurotoxicity Syndromes; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Solvents; Toluene | 2011 |
Age-related changes in the expression of NMDA, serotonin, and GAD in the central auditory system of the rat.
Topics: Aging; Animals; Auditory Cortex; Cochlear Nucleus; Geniculate Bodies; Glutamate Decarboxylase; Immunohistochemistry; Inferior Colliculi; Male; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Serotonin; Synaptic Transmission | 2012 |
Lifelong rapamycin administration ameliorates age-dependent cognitive deficits by reducing IL-1β and enhancing NMDA signaling.
Topics: Aging; Animals; Drosophila melanogaster; Interleukin-1beta; Learning; Memory Disorders; Mice; N-Methylaspartate; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases | 2012 |
D₁-NMDA receptor interactions in the rat nucleus accumbens change during adolescence.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Animals; Corpus Striatum; Dopamine; Dopamine Agonists; Glutamic Acid; N-Methylaspartate; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, N-Methyl-D-Aspartate | 2012 |
Effect of ageing on post-lesion oestradiol treatment on mouse cholinergic neurones in vivo.
Topics: Aging; Animals; Basal Nucleus of Meynert; Cell Death; Cholinergic Neurons; Disease Models, Animal; Estradiol; Estrous Cycle; Female; Male; Mice; Mice, Inbred C57BL; Microinjections; Molecular Imaging; N-Methylaspartate; Nerve Degeneration; Neural Pathways; Neuroprotective Agents; Somatosensory Cortex | 2012 |
Diminished cortical inhibition in an aging mouse model of chronic tinnitus.
Topics: Acoustic Stimulation; Aging; Animals; Auditory Cortex; Auditory Threshold; Cerebral Cortex; Chronic Disease; Disease Models, Animal; Evoked Potentials, Auditory, Brain Stem; Flavoproteins; GABA Antagonists; gamma-Aminobutyric Acid; Hearing Loss, Noise-Induced; Male; Mice; Mice, Inbred CBA; N-Methylaspartate; Neural Inhibition; Pyridazines; Receptors, GABA-A; Reflex, Startle; Tinnitus | 2012 |
Interaction of excitatory amino acid agonists with cortical afterdischarges in developing rats.
Topics: Aging; Animals; Cerebral Cortex; Electric Stimulation; Electrophysiology; Epilepsy; Excitatory Amino Acid Agonists; Homocysteine; Kainic Acid; N-Methylaspartate; Rats; Rats, Wistar | 2002 |
Age dependent NMDA contribution to impaired hypotensive cerebral hemodynamics following brain injury.
Topics: Aging; Animals; Animals, Newborn; Blood Chemical Analysis; Brain Injuries; Cerebral Arteries; Cerebrovascular Circulation; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Female; Homeostasis; Hypotension; Male; Microspheres; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Swine | 2002 |
How does prolonged caloric restriction ameliorate age-related impairment of long-term potentiation in the hippocampus?
Topics: 2-Amino-5-phosphonovalerate; Aging; Animals; Arachidonic Acid; Calcium; Calcium Signaling; Caloric Restriction; Docosahexaenoic Acids; Excitatory Amino Acid Antagonists; Fatty Acids, Unsaturated; Food Deprivation; Hippocampus; Long-Term Potentiation; Male; Membrane Lipids; N-Methylaspartate; Neural Pathways; Neurons; Organ Culture Techniques; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Valine | 2003 |
Oxygen sensitivity of NMDA receptors: relationship to NR2 subunit composition and hypoxia tolerance of neonatal neurons.
Topics: Aging; Animals; Animals, Newborn; Asphyxia Neonatorum; Brain; Calcium; Hippocampus; Humans; Hypoxia, Brain; Infant, Newborn; N-Methylaspartate; Neurons; Oocytes; Organ Culture Techniques; Oxygen; Phalloidine; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Xenopus laevis | 2003 |
Differential effects of estrogen in the injured forebrain of young adult and reproductive senescent animals.
Topics: Aging; Analysis of Variance; Animals; Diagonal Band of Broca; Enzyme-Linked Immunosorbent Assay; Estrogen Replacement Therapy; Estrogens; Excitatory Amino Acid Agonists; Female; Inflammation; Interleukin-1; Interleukin-10; Lectins; Microglia; N-Methylaspartate; Nerve Growth Factor; Olfactory Bulb; Ovariectomy; Prosencephalon; Rats; Reproduction | 2003 |
Acute dissociation for analyses of NMDA receptor function in cortical neurons during aging.
Topics: Aging; Animals; Calcium; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Male; Membrane Potentials; Mice; Mice, Inbred C57BL; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Piperidines; Receptors, N-Methyl-D-Aspartate; Time Factors | 2003 |
Down-regulation of CYP1A2 induction during the maturation of mouse cerebellar granule cells in culture: role of nitric oxide accumulation.
Topics: Aging; Aniline Compounds; Animals; Animals, Newborn; Calcimycin; Calcium; Cells, Cultured; Cellular Senescence; Cerebellum; Citrulline; Copper Sulfate; Cytochrome P-450 CYP1A2; Dizocilpine Maleate; DNA-Binding Proteins; Down-Regulation; Enzyme Induction; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Fluoresceins; Ionophores; Mice; Mice, Inbred C57BL; N-Methylaspartate; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Tritium; Xanthenes | 2003 |
The PDGF B-chain is involved in the ontogenic susceptibility of the developing rat brain to NMDA toxicity.
Topics: Aging; Analysis of Variance; Animals; Animals, Newborn; Brain; Chlorocebus aethiops; COS Cells; Disease Susceptibility; DNA; Drug Interactions; Excitatory Amino Acid Agonists; Immunoblotting; Immunohistochemistry; N-Methylaspartate; Oligoribonucleotides, Antisense; Proto-Oncogene Proteins c-sis; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Transfection | 2004 |
Hypoxic/ischaemic cell damage in cultured human NT-2 neurons.
Topics: Aging; Calcimycin; Calcium; Cell Death; Cell Line, Tumor; Cell Survival; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Fluorescein; Glutamic Acid; Humans; Hypoxia; Ionophores; Mitochondria; N-Methylaspartate; Neurons; Teratocarcinoma; Time Factors | 2004 |
Biphasic effect of acamprosate on NMDA but not on GABAA receptors in spontaneous rhythmic activity from the isolated neonatal rat respiratory network.
Topics: Acamprosate; Aging; Alcohol Deterrents; Animals; Animals, Newborn; Hypoglossal Nerve; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Respiratory Mechanics; Taurine | 2004 |
Layer-specific production of nitric oxide during cortical circuit formation in postnatal mouse brain.
Topics: Aging; Anatomy, Cross-Sectional; Animals; Animals, Newborn; Mice; Mice, Inbred ICR; N-Methylaspartate; Nerve Net; Neural Pathways; Neuronal Plasticity; Neurons; Nitric Oxide; Nitric Oxide Synthase; Somatosensory Cortex; Tissue Distribution | 2005 |
Potential for neural regeneration after neurotoxic injury in the adult mammalian retina.
Topics: Aging; Animals; Basic Helix-Loop-Helix Transcription Factors; Cell Differentiation; Cell Division; Eye Proteins; Gene Expression Regulation; Homeodomain Proteins; Immunohistochemistry; Male; N-Methylaspartate; Nerve Regeneration; Nerve Tissue Proteins; Neuroglia; Neurons; Paired Box Transcription Factors; PAX6 Transcription Factor; Rats; Rats, Sprague-Dawley; Repressor Proteins; Retina; Rhodopsin; Trans-Activators; Tretinoin | 2004 |
Dopamine and GABA increases produced by activation of glutamate receptors in the nucleus accumbens are decreased during aging.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analysis of Variance; Animals; Brain Chemistry; Chromatography, High Pressure Liquid; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Fluorometry; gamma-Aminobutyric Acid; Homovanillic Acid; Male; Microdialysis; N-Methylaspartate; Nucleus Accumbens; Rats; Rats, Wistar; Receptors, Glutamate | 2005 |
Deletion of the NR2A subunit prevents developmental changes of NMDA-mEPSCs in cultured mouse cerebellar granule neurones.
Topics: Action Potentials; Aging; Animals; Cell Line; Cerebellum; Excitatory Postsynaptic Potentials; Gene Deletion; Mice; Mutagenesis, Site-Directed; N-Methylaspartate; Neuronal Plasticity; Neurons; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Tissue Distribution | 2005 |
Neuroprotection by the PGE2 EP2 receptor in permanent focal cerebral ischemia.
Topics: Aging; Alprostadil; Animals; Brain Ischemia; Cell Death; Cerebral Infarction; Chronic Disease; Excitatory Amino Acid Agonists; Hippocampus; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Neurons; Rats; Rats, Sprague-Dawley; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP2 Subtype | 2005 |
Effects of synaptic activity on dendritic spine motility of developing cortical layer v pyramidal neurons.
Topics: Actins; Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anesthetics, Local; Animals; Cell Movement; Cerebral Cortex; Dendrites; Excitatory Amino Acid Agonists; Image Processing, Computer-Assisted; Immunohistochemistry; Male; Mice; Mice, Transgenic; Microscopy, Confocal; N-Methylaspartate; Nerve Net; Peptide Fragments; Potassium Chloride; Pyramidal Cells; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Synapses; Tetrodotoxin | 2006 |
NMDA receptor activation modulates programmed cell death during early post-natal retinal development: a BDNF-dependent mechanism.
Topics: Aging; Animals; Animals, Newborn; Apoptosis; Brain-Derived Neurotrophic Factor; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; N-Methylaspartate; Nerve Growth Factors; Neuroprotective Agents; Rats; Rats, Inbred Strains; Receptor, trkB; Receptors, N-Methyl-D-Aspartate; Retina; RNA, Messenger | 2005 |
NMDA modulation of dopamine dynamics is diminished in the aged striatum: an in vivo voltametric study.
Topics: Aging; Animals; Corpus Striatum; Dopamine; Electrochemistry; Male; Microinjections; N-Methylaspartate; Potassium; Rats; Rats, Sprague-Dawley | 2006 |
Social isolation stress impairs passive avoidance learning in senescence-accelerated mouse (SAM).
Topics: Aging; Animals; Avoidance Learning; Brain; Corticosterone; Darkness; Light; Memory; Mice; Mice, Mutant Strains; N-Methylaspartate; Social Isolation; Space Perception; Stress, Psychological | 2006 |
NMDA-NR1 and AMPA-GluR4 receptor subunit immunoreactivities in the absence epileptic WAG/Rij rat.
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anterior Thalamic Nuclei; Disease Models, Animal; Electroencephalography; Epilepsy, Absence; Immunohistochemistry; Male; N-Methylaspartate; Rats; Rats, Inbred ACI; Rats, Inbred Strains; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Somatosensory Cortex | 2006 |
Neuroprotective role of neurokinin B (NKB) on beta-amyloid (25-35) induced toxicity in aging rat brain synaptosomes: involvement in oxidative stress and excitotoxicity.
Topics: Aging; Amyloid beta-Peptides; Animals; Brain; Calcium Signaling; Drug Interactions; Female; Free Radical Scavengers; Glutamic Acid; In Vitro Techniques; Monoamine Oxidase; N-Methylaspartate; Neurokinin B; Neuroprotective Agents; Neurotransmitter Agents; Oxidative Stress; Peptide Fragments; Rats; Rats, Wistar; Superoxide Dismutase; Synaptosomes | 2006 |
Apoptotic retinal ganglion cell death in the DBA/2 mouse model of glaucoma.
Topics: Aging; Animals; Annexin A5; Disease Models, Animal; Female; Glaucoma; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; N-Methylaspartate; Retinal Ganglion Cells; Species Specificity | 2007 |
Delayed neurodegeneration and early astrogliosis after excitotoxicity to the aged brain.
Topics: Aging; Animals; Astrocytes; Brain; Brain Edema; Cell Count; Corpus Striatum; Excitatory Amino Acid Agonists; Glial Fibrillary Acidic Protein; Gliosis; Immunohistochemistry; Male; N-Methylaspartate; Nerve Degeneration; Neurons; Rats; Rats, Wistar; Time Factors | 2007 |
The function of the glutamate-nitric oxide-cGMP pathway in brain in vivo and learning ability decrease in parallel in mature compared with young rats.
Topics: Aging; Animals; Brain; Cyclic GMP; Female; Glutamic Acid; Immunoblotting; Male; Maze Learning; Microdialysis; N-Methylaspartate; Nitric Oxide; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 2007 |
Increased vulnerability of hippocampal neurons with age in culture: temporal association with increases in NMDA receptor current, NR2A subunit expression and recruitment of L-type calcium channels.
Topics: Aging; Animals; Calcium; Calcium Channels, L-Type; Cell Survival; Cells, Cultured; Dizocilpine Maleate; Embryo, Mammalian; Female; Gene Expression; Glutamic Acid; Hippocampus; L-Lactate Dehydrogenase; Membrane Potentials; N-Methylaspartate; Neurons; Neuroprotective Agents; Patch-Clamp Techniques; Pregnancy; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2007 |
Effect of ageing on Ca2+ uptake via NMDA receptors into barrel cortex slices of spontaneously hypertensive rats.
Topics: Aging; Animals; Calcium; Excitatory Amino Acid Agonists; Female; Hypertension; Male; N-Methylaspartate; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, N-Methyl-D-Aspartate; Somatosensory Cortex; Species Specificity | 2008 |
Effects of estrogen receptor agonists on regulation of the inflammatory response in astrocytes from young adult and middle-aged female rats.
Topics: Aging; Animals; Astrocytes; Calcium-Binding Proteins; CD11b Antigen; Cells, Cultured; Drug Interactions; Estrogens; Excitatory Amino Acid Agonists; Female; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Inflammation; Lipopolysaccharides; Microfilament Proteins; Microtubule-Associated Proteins; N-Methylaspartate; Olfactory Bulb; Ovariectomy; Rats; Receptors, Estrogen; Tumor Necrosis Factor-alpha | 2008 |
Specific and non-specific effects of neuro-excitatory amino acids on learning and other behaviours in the chicken.
Topics: Aggression; Aging; Animals; Aspartic Acid; Behavior, Animal; Chickens; Copulation; Glutamates; Glutamic Acid; Habituation, Psychophysiologic; Humans; Kainic Acid; Learning; N-Methylaspartate; Pattern Recognition, Visual; Pyrrolidines; Visual Perception | 1982 |
Glycine release from hippocampal slices in developing and ageing mice: modulation by glutamatergic receptors.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Dizocilpine Maleate; Female; Glycine; Hippocampus; In Vitro Techniques; Kainic Acid; Male; Mice; N-Methylaspartate; Potassium; Quisqualic Acid; Receptors, Glutamate; Tetrazoles | 1994 |
Age-related changes in the NMDA receptor/nitric oxide/cGMP pathway in the hippocampus and cerebellum of freely moving rats subjected to transcerebral microdialysis.
Topics: Aging; Amino Acid Oxidoreductases; Animals; Behavior, Animal; Cerebellum; Cyclic GMP; Extracellular Space; Guanylate Cyclase; Hippocampus; Male; Microdialysis; N-Methylaspartate; Nitric Oxide; Nitric Oxide Synthase; Penicillamine; Phosphodiesterase Inhibitors; Rats; Rats, Inbred WKY; Receptors, N-Methyl-D-Aspartate; S-Nitroso-N-Acetylpenicillamine; Serine; Vasodilator Agents | 1995 |
Developmental change of the potentiation of NMDA response by spermine.
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Drug Synergism; Electrophysiology; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Neurons; Nystatin; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Spermine; Ventromedial Hypothalamic Nucleus | 1995 |
NMDA antagonism during development extends sparing of hindlimb function to older spinally transected rats.
Topics: Aging; Animals; Animals, Newborn; Denervation; Dizocilpine Maleate; Electrophysiology; Hindlimb; N-Methylaspartate; Neuronal Plasticity; Rats; Rats, Sprague-Dawley; Spinal Cord | 1995 |
Rapid acquisition of dendritic spines by visual thalamic neurons after blockade of N-methyl-D-aspartate receptors.
Topics: 2-Amino-5-phosphonovalerate; Aging; Animals; Animals, Newborn; Dendrites; Female; Ferrets; Geniculate Bodies; In Vitro Techniques; Microscopy, Confocal; N-Methylaspartate; Neurons; Pregnancy; Receptors, N-Methyl-D-Aspartate; Reference Values | 1995 |
Loss of cortical serotonin2A signal transduction in senescent rats: reversal following inhibition of protein kinase C.
Topics: Aging; Alkaloids; Animals; Cerebral Cortex; Electrophysiology; In Situ Hybridization; Male; N-Methylaspartate; Protein Kinase C; Rats; Rats, Inbred F344; Receptors, Serotonin; Serotonin; Signal Transduction; Staurosporine | 1995 |
Prenatal exposure of rats to ammonia impairs NMDA receptor function and affords delayed protection against ammonia toxicity and glutamate neurotoxicity.
Topics: Aging; Ammonia; Animals; Aspartate Aminotransferases; Cells, Cultured; Cerebellum; Diet; Dizocilpine Maleate; Female; Glutamic Acid; L-Lactate Dehydrogenase; Lactation; N-Methylaspartate; Neurons; Neurotoxins; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 1995 |
Development of dopamine and N-methyl-D-aspartate systems in rat brain: the effect of prenatal phencyclidine exposure.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Animals; Animals, Newborn; Corpus Striatum; Dopamine; Female; Frontal Lobe; Glutamates; Glutamic Acid; Hydroxyindoleacetic Acid; Male; Methamphetamine; N-Methylaspartate; Phencyclidine; Pipecolic Acids; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley | 1993 |
Postnatal changes in the role of NMDA in the isolated spinal cord of the hamster, Mesocricetus auratus.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Aging; Animals; Cricetinae; In Vitro Techniques; Magnesium; Mesocricetus; N-Methylaspartate; Spinal Cord | 1994 |
Ontogenically related properties of N-methyl-D-aspartate receptors in rat hippocampal neurons and the age-specific sensitivity of developing neurons to lead.
Topics: Aging; Animals; Hippocampus; Lead; Membrane Potentials; N-Methylaspartate; Neurons; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Trypsin | 1995 |
Carbachol-induced accumulation of inositol phosphates and its modulation by excitatory amino acids in cortical slices of young and aged rats with down-regulation of muscarinic M-1 receptors.
Topics: Aging; Analysis of Variance; Animals; Carbachol; Cerebral Cortex; Down-Regulation; Excitatory Amino Acids; Glutamic Acid; In Vitro Techniques; Inositol Phosphates; Isoflurophate; Male; N-Methylaspartate; Rats; Rats, Inbred F344; Receptors, Muscarinic; Syndrome | 1994 |
Mechanisms underlying developmental changes in the expression of metabotropic glutamate receptors in cultured cerebellar granule cells: homologous desensitization and interactive effects involving N-methyl-D-aspartate receptors.
Topics: Aging; Animals; Carbachol; Cells, Cultured; Cerebellum; Glutamates; Glutamic Acid; Hydrolysis; N-Methylaspartate; Phosphatidylinositol Phosphates; Potassium; Quisqualic Acid; Rats; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; RNA, Messenger | 1993 |
Differential responses in cyclic GMP formation induced by excitatory amino acids (EAA) and sodium nitroprusside (SNP) in various regions of the brain and of rats of varied age.
Topics: Aging; Amino Acids; Animals; Brain; Cyclic GMP; Female; Glutamates; Glutamic Acid; In Vitro Techniques; Kainic Acid; Male; N-Methylaspartate; Nitroprusside; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sex Characteristics | 1993 |
Release of 3H-noradrenaline by excitatory amino acids from rat mediobasal hypothalamus and the influence of aging.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; Amino Acids; Animals; Glutamates; Glutamic Acid; Hypothalamus, Middle; In Vitro Techniques; Kainic Acid; Male; N-Methylaspartate; Norepinephrine; Quinoxalines; Rats; Tritium | 1994 |
3-Acetylpyridine produces age-dependent excitotoxic lesions in rat striatum.
Topics: Adenosine Triphosphate; Aging; Animals; Corpus Striatum; Dose-Response Relationship, Drug; Energy Metabolism; Male; N-Methylaspartate; Neurotoxins; Pyridines; Rats; Rats, Sprague-Dawley | 1994 |
Responses of cerebral arterioles to N-methyl-D-aspartate and activation of ATP-sensitive potassium channels in old rats.
Topics: Adenosine Triphosphate; Aging; Animals; Arterioles; Cerebrovascular Circulation; Dose-Response Relationship, Drug; Male; N-Methylaspartate; Picolines; Potassium Channels; Pyrans; Rats; Rats, Inbred F344; Vasodilator Agents | 1994 |
Regulation of D-aspartate release by glutamate and GABA receptors in cerebral cortical slices from developing and ageing mice.
Topics: Aging; Animals; Aspartic Acid; Cerebellum; Cerebral Cortex; Excitatory Amino Acid Antagonists; Female; GABA Antagonists; gamma-Aminobutyric Acid; Glycine; In Vitro Techniques; Kainic Acid; Male; Mice; N-Methylaspartate; Quisqualic Acid; Receptors, GABA; Receptors, GABA-A; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Taurine | 1994 |
Different proportions of N-methyl-D-aspartate and non-N-methyl-D-aspartate receptor currents at the mossy fibre-granule cell synapse of developing rat cerebellum.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; Animals; Bicuculline; Cerebellum; Cytoplasmic Granules; Electrophysiology; Evoked Potentials; In Vitro Techniques; Kinetics; Magnesium; N-Methylaspartate; Nerve Fibers; Neurons; Neurons, Afferent; Quinoxalines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Synapses; Tetrodotoxin | 1993 |
Glutamate and theta-rhythm stimulation selectively enhance NMDA component of EPSC in CA1 neurons of young rats.
Topics: Aging; Animals; Arginine; Evoked Potentials; Glutamates; Glutamic Acid; Hemoglobins; In Vitro Techniques; N-Methylaspartate; Neuronal Plasticity; Neurons; Nitroarginine; Norepinephrine; Rats; Rats, Wistar; Synapses; Synaptic Transmission; Theta Rhythm | 1993 |
Effects of excitatory amino acids on inositol phosphate accumulation in slices of the cerebral cortex of young and aged rats.
Topics: Aging; Amino Acids; Animals; Carbachol; Cerebral Cortex; Glutamates; Glutamic Acid; Inositol Phosphates; Male; N-Methylaspartate; Norepinephrine; Quisqualic Acid; Rats; Rats, Sprague-Dawley | 1993 |
Age-related effects of NMDA-stimulated concomitant release of nitric oxide and glutamate in cortical slices prepared from DBA/2 mice.
Topics: Acoustic Stimulation; Aging; Animals; Cerebral Cortex; Disease Susceptibility; Female; Glutamates; Glutamic Acid; In Vitro Techniques; Male; Mice; Mice, Inbred DBA; N-Methylaspartate; Nitric Oxide; Seizures | 1993 |
Hypoxic-ischemic brain injury stimulates glial fibrillary acidic protein mRNA and protein expression in neonatal rats.
Topics: Aging; Animals; Animals, Newborn; Blotting, Northern; Brain; Brain Ischemia; Cerebral Cortex; Corpus Striatum; Dizocilpine Maleate; Functional Laterality; Glial Fibrillary Acidic Protein; Hippocampus; Hypoxia, Brain; Immunohistochemistry; N-Methylaspartate; Organ Specificity; Rats; Rats, Sprague-Dawley; RNA, Messenger | 1994 |
Opioidergic modulation of N-methyl-D,L-aspartic-acid-stimulated LH release in young adult but not older male mice.
Topics: Aging; Animals; Cardiac Catheterization; Dose-Response Relationship, Drug; Endorphins; Gonadotropin-Releasing Hormone; Luteinizing Hormone; Male; Mice; Mice, Inbred C3H; N-Methylaspartate; Naloxone; Radioimmunoassay | 1994 |
Neural development following NMDA administration in the rat: an electron microscopic examination of the occipital neocortex layer I.
Topics: Aging; Animals; Dose-Response Relationship, Drug; Lethal Dose 50; Male; Microscopy, Electron; N-Methylaspartate; Nervous System; Occipital Lobe; Rats; Seizures; Time Factors | 1994 |
Autoradiographic localisation of NMDA binding sites in brainstem cardiorespiratory areas of adult and newborn cats.
Topics: Aging; Animals; Animals, Newborn; Autoradiography; Binding Sites; Brain Mapping; Brain Stem; Cats; Illicit Drugs; Membrane Potentials; N-Methylaspartate; Neurons; Phencyclidine; Pons; Receptors, N-Methyl-D-Aspartate; Tritium | 1993 |
Expression of a mitogen-inducible cyclooxygenase in brain neurons: regulation by synaptic activity and glucocorticoids.
Topics: Aging; Amino Acid Sequence; Animals; Brain; DNA; Glucocorticoids; Male; Mitogens; Molecular Sequence Data; N-Methylaspartate; Neurons; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred Strains; RNA, Messenger; Seizures; Stress, Physiological; Synapses | 1993 |
Age- and dose-related NMDA induction of Fos-like immunoreactivity and c-fos mRNA in the arcuate nucleus of immature female rats.
Topics: Aging; Animals; Arcuate Nucleus of Hypothalamus; Autoradiography; Dose-Response Relationship, Drug; Female; Gene Expression; Genes, fos; Immunohistochemistry; In Situ Hybridization; Median Eminence; N-Methylaspartate; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; RNA, Messenger | 1993 |
Cholinergic regulation of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) but not neurotrophin-3 (NT-3) mRNA levels in the developing rat hippocampus.
Topics: Aging; Animals; Animals, Newborn; Brain-Derived Neurotrophic Factor; Cerebral Ventricles; Dizocilpine Maleate; Gene Expression; Hippocampus; In Situ Hybridization; Injections, Intraventricular; Kainic Acid; Male; N-Methylaspartate; Nerve Growth Factors; Nerve Tissue Proteins; Neurons; Neurotrophin 3; Pilocarpine; Pyramidal Tracts; Rats; Rats, Wistar; RNA Probes; RNA, Messenger; Scopolamine; Transcription, Genetic | 1993 |
Age-related decrease of the NMDA receptor-mediated noradrenaline release in rat hippocampus and partial restoration by D-cycloserine.
Topics: Aging; Animals; Cycloserine; Glycine; Hippocampus; In Vitro Techniques; Male; N-Methylaspartate; Norepinephrine; Rats; Rats, Inbred WKY; Receptors, N-Methyl-D-Aspartate; Stereoisomerism; Synaptosomes | 1993 |
Effects of aging on NMDA and MK801 binding sites in mice.
Topics: Aging; Animals; Binding Sites; Brain; Cerebral Cortex; Dizocilpine Maleate; Male; Mice; Mice, Inbred C57BL; N-Methylaspartate; Organ Specificity; Receptors, N-Methyl-D-Aspartate | 1993 |
Remote and chronic access to the third cerebral ventricle of the unrestrained prepubertal rhesus monkey.
Topics: Aging; Animals; Cerebral Ventricles; Gonadotropin-Releasing Hormone; Immobilization; Macaca mulatta; Male; Methods; Morphine; N-Methylaspartate; Radioimmunoassay | 1993 |
Age-dependent anticonvulsant action of clonazepam in the N-methyl-D-aspartate model of seizures.
Topics: Aging; Animals; Anticonvulsants; Behavior, Animal; Clonazepam; Electroencephalography; Epilepsy, Tonic-Clonic; Male; N-Methylaspartate; Rats; Rats, Wistar; Seizures | 1995 |
Neuroprotection against NMDA induced cell death in rat nucleus basalis by Ca2+ antagonist nimodipine, influence of aging and developmental drug treatment.
Topics: Aging; Analysis of Variance; Animals; Calcium Channel Blockers; Cell Count; Cell Death; Functional Laterality; Male; N-Methylaspartate; Neuroprotective Agents; Nimodipine; Rats; Rats, Wistar; Substantia Innominata | 1995 |
Regulation of alpha7 nicotinic acetylcholine receptors in the developing rat somatosensory cortex by thalamocortical afferents.
Topics: Aging; Animals; Animals, Newborn; Cerebral Cortex; N-Methylaspartate; Neurons, Afferent; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Somatosensory Cortex; Thalamus | 1996 |
Decreased gonadotropin-releasing hormone neurosecretory response to glutamate agonists in middle-aged female rats on proestrus afternoon: a possible role in reproductive aging?
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Arcuate Nucleus of Hypothalamus; Base Sequence; Excitatory Amino Acid Agonists; Female; Glutamic Acid; Gonadotropin-Releasing Hormone; Kainic Acid; Luteinizing Hormone; Median Eminence; Molecular Sequence Data; N-Methylaspartate; Preoptic Area; Proestrus; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; RNA, Messenger | 1996 |
Cytosolic Ca2+ buffering, a cell property that in some neurons markedly decreases during aging, has a protective effect against NMDA/nitric oxide-induced excitotoxicity.
Topics: Aging; Calcium; Cell Survival; Cellular Senescence; Cytosol; Egtazic Acid; Enzyme Inhibitors; N-Methylaspartate; Neurons; Nitric Oxide; Nitric Oxide Synthase; Tumor Cells, Cultured | 1996 |
Evidence that glyceraldehyde-3-phosphate dehydrogenase is involved in age-induced apoptosis in mature cerebellar neurons in culture.
Topics: Aging; Amino Acid Sequence; Animals; Apoptosis; Base Sequence; Cells, Cultured; Cellular Senescence; Cerebellum; Cycloheximide; Dactinomycin; Glyceraldehyde-3-Phosphate Dehydrogenases; Molecular Sequence Data; N-Methylaspartate; Neurons; Neuroprotective Agents; Oligonucleotide Probes; Oligonucleotides, Antisense; Rats; Rats, Sprague-Dawley; RNA, Messenger | 1996 |
Differential effects of N-methyl-D-aspartate on Ca2+ homeostasis in developing and adult rat striatum: in vivo microdialysis approach.
Topics: Aging; Amino Acids; Animals; Calcium; Calcium Radioisotopes; Excitatory Amino Acid Agonists; Homeostasis; Microdialysis; N-Methylaspartate; Neostriatum; Rats; Rats, Wistar; Sucrose | 1995 |
Use of subunit-specific antisense oligodeoxynucleotides to define developmental changes in the properties of N-methyl-D-aspartate receptors.
Topics: 2-Amino-5-phosphonovalerate; Aging; Animals; Animals, Newborn; Base Sequence; Cerebral Cortex; Excitatory Amino Acid Antagonists; Female; Gene Expression Regulation, Developmental; Glycine; Kynurenic Acid; Macromolecular Substances; Molecular Sequence Data; N-Methylaspartate; Oligonucleotides, Antisense; Oocytes; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Xenopus laevis | 1996 |
Aging reduces neostriatal responsiveness to N-methyl-D-aspartate and dopamine: an in vitro electrophysiological study.
Topics: Age Factors; Aging; Animals; Cats; Dopamine; Dose-Response Relationship, Drug; Evoked Potentials; Glutamic Acid; In Vitro Techniques; Male; N-Methylaspartate; Neostriatum; Rats; Rats, Inbred F344 | 1996 |
In vivo protection against NMDA-induced neurodegeneration by MK-801 and nimodipine: combined therapy and temporal course of protection.
Topics: Aging; Analysis of Variance; Animals; Brain; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Male; N-Methylaspartate; Nerve Degeneration; Nerve Fibers; Neurons; Nimodipine; Rats; Rats, Wistar | 1996 |
Ontogeny of NMDA R1 subunit protein expression in five regions of rat brain.
Topics: Aging; Animals; Animals, Newborn; Brain; Humans; Immune Sera; Immunoblotting; N-Methylaspartate; Peptide Fragments; Rats; Recombinant Fusion Proteins; Tissue Distribution | 1996 |
Stimulation of glutamine synthetase activity by excitatory amino acids in astrocyte cultures derived from aged mouse cerebral hemispheres may be associated with non-N-methyl-D-aspartate receptor activation.
Topics: 2-Amino-5-phosphonovalerate; Aging; Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Astrocytes; Cell Division; Cells, Cultured; Cerebral Cortex; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Amino Acids; Glutamate-Ammonia Ligase; Glutamic Acid; Mice; N-Methylaspartate; Neurotoxins; Quinoxalines; Receptors, N-Methyl-D-Aspartate | 1996 |
In vitro autoradiography of ionotropic glutamate receptors in hippocampus and striatum of aged Long-Evans rats: relationship to spatial learning.
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Autoradiography; Corpus Striatum; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Hippocampus; Kainic Acid; Male; Maze Learning; N-Methylaspartate; Organ Specificity; Prosencephalon; Rats; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Regression Analysis; Tritium | 1996 |
Effects of N-methyl-D-aspartate and kainic acid on prolactin secretion in prepubertal female rats.
Topics: Aging; Animals; Dopamine; Enzyme Inhibitors; Female; Kainic Acid; N-Methylaspartate; NG-Nitroarginine Methyl Ester; Pituitary Gland; Prolactin; Rats; Rats, Wistar; Serotonin; Sexual Maturation | 1996 |
Increased vulnerability of septal cholinergic neurons to partial loss of target neurons in aged rats.
Topics: Acetylcholine; Aging; Animals; Apoptosis; Atrophy; Choline O-Acetyltransferase; Hippocampus; Male; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Neurotoxins; Rats; Rats, Sprague-Dawley; Receptor, Nerve Growth Factor; Receptors, Nerve Growth Factor; Septum Pellucidum | 1996 |
Effects of aging on N-methyl-D-aspartate (NMDA)-induced GnRH and LH release in female rats.
Topics: Aging; Animals; Female; Gonadotropin-Releasing Hormone; Luteinizing Hormone; N-Methylaspartate; Rats; Rats, Wistar | 1996 |
Different responses of gonadotropin-releasing hormone (GnRH) release to glutamate receptor agonists during aging.
Topics: Age Factors; Aging; Animals; Gonadotropin-Releasing Hormone; Male; N-Methylaspartate; Rats; Rats, Inbred WKY; Receptors, Glutamate | 1996 |
Serotonergic function of aging hippocampal CA3 pyramidal neurons: electrophysiological assessment following administration of 5,7-dihydroxytryptamine in the fimbria-fornix and cingulum bundle.
Topics: 5,7-Dihydroxytryptamine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Anesthetics, Intravenous; Animals; Chloral Hydrate; Electrophysiology; Excitatory Amino Acid Agonists; Female; Gyrus Cinguli; Iontophoresis; N-Methylaspartate; Piperazines; Pyramidal Cells; Rats; Rats, Inbred F344; Serotonin; Serotonin Agents; Serotonin Antagonists; Serotonin Receptor Agonists | 1997 |
Developmental study of N-methyl-D-aspartate-induced firing activity and whole-cell currents in nucleus tractus solitarii neurons.
Topics: Aging; Animals; Animals, Newborn; Electric Conductivity; In Vitro Techniques; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Rats; Solitary Nucleus | 1996 |
N-methyl-D-aspartate-mediated glutamate toxicity in the developing rabbit retina.
Topics: 2-Amino-5-phosphonovalerate; Aging; Animals; Animals, Newborn; Cell Death; Cyclic GMP; Dextromethorphan; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glutamic Acid; N-Methylaspartate; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Rabbits; Receptors, N-Methyl-D-Aspartate; Retina | 1997 |
Hippocampal N-methyl-D-aspartate and kainate binding in response to entorhinal cortex aspiration or 192 IgG-saporin lesions of the basal forebrain.
Topics: Acetylcholinesterase; Aging; Animals; Antibodies, Monoclonal; Cholinergic Agents; Entorhinal Cortex; Glutamic Acid; Hippocampus; Immunotoxins; Kainic Acid; Kinetics; Male; N-Glycosyl Hydrolases; N-Methylaspartate; Neurons; Prosencephalon; Pyramidal Tracts; Radioligand Assay; Rats; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Ribosome Inactivating Proteins, Type 1; Saporins; Tritium | 1997 |
Specific [3H]glutamate binding in the cerebral cortex and hippocampus of rats during development: effect of homocysteine-induced seizures.
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analysis of Variance; Animals; Binding Sites; Cerebral Cortex; Glutamic Acid; Hippocampus; Homocysteine; Kainic Acid; Male; N-Methylaspartate; Quisqualic Acid; Rats; Rats, Wistar; Reference Values; Seizures; Synaptic Membranes; Tritium | 1997 |
Development in neonatal rats of the sensory resetting of the locomotor rhythm induced by NMDA and 5-HT.
Topics: Aging; Animals; Animals, Newborn; Electric Stimulation; Electromyography; Models, Neurological; Motor Activity; Muscle Contraction; Muscle Development; Muscle, Skeletal; N-Methylaspartate; Nerve Fibers; Neurons, Afferent; Peripheral Nerves; Rats; Rats, Wistar; Reflex; Serotonin; Synapses | 1997 |
Age dependent sensitivity of the rat retina to the excitotoxic action of N-methyl-D-aspartate.
Topics: Age Factors; Aging; Animals; Excitatory Amino Acid Agonists; Glutamic Acid; In Vitro Techniques; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Retina | 1995 |
Interactions between N-methyl-D-aspartate, nitric oxide and serotonin in the control of prolactin secretion in prepubertal male rats.
Topics: Aging; Animals; Dizocilpine Maleate; Drug Interactions; Enzyme Inhibitors; Male; N-Methylaspartate; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Orchiectomy; Prolactin; Rats; Rats, Wistar; Serotonin; Serotonin Receptor Agonists; Sexual Maturation; Testosterone | 1997 |
Dopamine modulation of responses mediated by excitatory amino acids in the neostriatum.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Animals; Brain; Dopamine; Dopamine Agonists; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; In Vitro Techniques; N-Methylaspartate; Neostriatum; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Synaptic Transmission | 1998 |
Effects of paraventricular lesions on sex behavior and seminal emission in male rats.
Topics: Aging; Animals; Body Temperature Regulation; Copulation; Ejaculation; Female; Immunohistochemistry; Male; N-Methylaspartate; Organ Size; Paraventricular Hypothalamic Nucleus; Rats; Sexual Behavior, Animal | 1997 |
Taurine release from the developing and ageing hippocampus: stimulation by agonists of ionotropic glutamate receptors.
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Excitatory Amino Acid Agonists; Female; Hippocampus; In Vitro Techniques; Kainic Acid; Male; Mice; N-Methylaspartate; Receptors, Glutamate; Taurine | 1997 |
Aging results in attenuated gonadotropin releasing hormone-luteinizing hormone axis responsiveness to glutamate receptor agonist N-methyl-D-aspartate.
Topics: Aging; Animals; Excitatory Amino Acid Agonists; Follicle Stimulating Hormone; Gonadotropin-Releasing Hormone; Gonadotropins; Luteinizing Hormone; Male; N-Methylaspartate; Pituitary Gland; Prolactin; Rats; Rats, Inbred BN; Receptors, Glutamate | 1998 |
Hypoxia-tolerant neonatal CA1 neurons: relationship of survival to evoked glutamate release and glutamate receptor-mediated calcium changes in hippocampal slices.
Topics: Aging; Animals; Animals, Newborn; Calcium; Cell Hypoxia; Cell Survival; Cytosol; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; In Vitro Techniques; Membrane Potentials; N-Methylaspartate; Neurons; Rats; Rats, Sprague-Dawley | 1998 |
Dopaminergic control of kynurenate levels and N-methyl-D-aspartate toxicity in the developing rat striatum.
Topics: Aging; Animals; Animals, Newborn; Corpus Striatum; Dextroamphetamine; Dopamine; Dopamine Agents; Dopamine Antagonists; Excitatory Amino Acid Agonists; Haloperidol; Injections; Kynurenic Acid; Ligands; Male; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2 | 1998 |
Experience-dependent changes in the importance of N-methyl-D-aspartate (NMDA) receptors for visual transmission in superior colliculus.
Topics: 2-Amino-5-phosphonovalerate; Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Darkness; Gene Expression Regulation, Developmental; N-Methylaspartate; Neurons; Rats; Receptors, N-Methyl-D-Aspartate; Sensory Deprivation; Superior Colliculi; Visual Perception | 1998 |
Excitatory amino acid regulation of gonadotropin secretion in prepubertal heifer calves.
Topics: Aging; Animals; Cattle; Excitatory Amino Acids; Female; Follicle Stimulating Hormone; Luteinizing Hormone; N-Methylaspartate; Periodicity; Receptors, N-Methyl-D-Aspartate; Sexual Maturation | 1998 |
Differential blood-brain barrier breakdown and leucocyte recruitment following excitotoxic lesions in juvenile and adult rats.
Topics: Aging; Animals; Astrocytes; Biomarkers; Blood-Brain Barrier; Brain; Excitatory Amino Acid Agonists; Immunoenzyme Techniques; Inflammation; Kainic Acid; Leukocytes; Male; Microglia; N-Methylaspartate; Nerve Degeneration; Permeability; Rats; Rats, Wistar; Time Factors | 1998 |
Gonadal and age-related influences on NMDA-induced growth hormone secretion in male rats.
Topics: 2-Amino-5-phosphonovalerate; Aging; Animals; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Growth Hormone; Growth Hormone-Releasing Hormone; Male; N-Methylaspartate; Orchiectomy; Periodicity; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Sodium Glutamate; Testis; Testosterone | 1999 |
Low resting potential and postnatal upregulation of NMDA receptors may cause Cajal-Retzius cell death.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Adenosine Triphosphate; Aging; Animals; Cell Death; Cerebral Cortex; Dizocilpine Maleate; Embryo, Mammalian; Excitatory Amino Acid Antagonists; Immunohistochemistry; In Vitro Techniques; Meglumine; Membrane Potentials; N-Methylaspartate; Neurons; Neuroprotective Agents; Patch-Clamp Techniques; Piperazines; Rats; Rats, Inbred F344; Receptors, N-Methyl-D-Aspartate; Tetrodotoxin; Up-Regulation | 1999 |
Age-dependent differences in glutamate-induced phosphorylation systems in rat hippocampal slices.
Topics: Aging; Animals; Brain Chemistry; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin-Binding Proteins; Casein Kinase II; Cyclic AMP-Dependent Protein Kinases; Dynamins; Excitatory Amino Acid Agonists; Glutamic Acid; GTP Phosphohydrolases; Hippocampus; Intramolecular Oxidoreductases; Lipocalins; Male; Methoxyhydroxyphenylglycol; N-Methylaspartate; Nerve Tissue Proteins; Neurogranin; Organ Culture Techniques; Perchlorates; Phosphoproteins; Phosphorylation; Protein Kinase C; Protein Serine-Threonine Kinases; Rats; Rats, Wistar; Signal Transduction; Solubility; Subcellular Fractions; tau Proteins | 1999 |
Taurine release modified by nitric oxide-generating compounds in the developing and adult mouse hippocampus.
Topics: Aging; Animals; Hippocampus; Hydroxylamine; In Vitro Techniques; Indazoles; Mice; Mice, Inbred Strains; N-Methylaspartate; Nitric Oxide Donors; Nitroarginine; Nitroprusside; Penicillamine; Potassium; S-Nitroso-N-Acetylpenicillamine; Taurine | 1999 |
Effects of choline and other nicotinic agonists on the tectum of juvenile and adult Xenopus frogs: a patch-clamp study.
Topics: Aging; Alkaloids; Animals; Axons; Azocines; Carbachol; Choline; Excitatory Postsynaptic Potentials; Mecamylamine; Metamorphosis, Biological; Models, Neurological; N-Methylaspartate; Nerve Regeneration; Neurons; Nicotine; Nicotinic Agonists; Patch-Clamp Techniques; Quinolizines; Receptors, Cholinergic; Receptors, Nicotinic; Superior Colliculi; Vision, Binocular; Visual Pathways; Xenopus laevis | 1999 |
Developmental regulation of intracellular calcium by N-methyl-D-aspartate and noradrenaline in rat visual cortex.
Topics: Adrenergic alpha-Agonists; Aging; Animals; Calcium; Excitatory Amino Acid Agonists; Fluorescent Dyes; Fura-2; Glial Fibrillary Acidic Protein; Image Processing, Computer-Assisted; In Vitro Techniques; Intracellular Membranes; N-Methylaspartate; Norepinephrine; Rats; Rats, Long-Evans; Visual Cortex | 1999 |
Subpopulations of GABAergic and non-GABAergic rat dorsal horn neurons express Ca2+-permeable AMPA receptors.
Topics: Aging; Animals; Calcium; Calcium-Binding Proteins; Cobalt; gamma-Aminobutyric Acid; Glycine; Immunohistochemistry; N-Methylaspartate; Neurons; Neurotoxins; Permeability; Rats; Receptors, AMPA; Receptors, Neurokinin-1; Spinal Cord; Tyrosine 3-Monooxygenase | 1999 |
Early prepubertal ontogeny of pulsatile gonadotropin-releasing hormone (GnRH) secretion: I. Inhibitory autofeedback control through prolyl endopeptidase degradation of GnRH.
Topics: Aging; Animals; Animals, Newborn; Enzyme Inhibitors; Feedback; Fetus; Gonadotropin-Releasing Hormone; Hypothalamus; Male; N-Methylaspartate; Prolyl Oligopeptidases; Pulsatile Flow; Rats; Rats, Wistar; RNA, Messenger; Serine Endopeptidases | 1999 |
Differential bicuculline-induced epileptogenesis in rat neonatal, juvenile and adult CA3 pyramidal neurons in vitro.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Aging; Animals; Animals, Newborn; Bicuculline; Epilepsy; Excitatory Amino Acid Antagonists; GABA Antagonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; N-Methylaspartate; Piperazines; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate | 1999 |
The ontogeny of glutamate receptors and D-aspartate binding sites in the ovine CNS.
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Aspartic Acid; Autoradiography; Binding Sites; Brain; Embryonic and Fetal Development; Fetus; Glutamic Acid; Kainic Acid; N-Methylaspartate; Receptors, Glutamate; Sheep | 1999 |
Chronic NMDA exposure accelerates development of GABAergic inhibition in the superior colliculus.
Topics: Aging; Animals; Carrier Proteins; Coloring Agents; Electrophysiology; Female; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Immunohistochemistry; Lysine; Membrane Potentials; Membrane Proteins; Membrane Transport Proteins; N-Methylaspartate; Neurons; Organic Anion Transporters; Patch-Clamp Techniques; Pregnancy; Rats; Rats, Sprague-Dawley; Superior Colliculi | 2000 |
Modulation and function of kynurenic acid in the immature rat brain.
Topics: 2-Amino-5-phosphonovalerate; Aging; Alanine; Animals; Brain; Dextroamphetamine; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glucose; Kynurenic Acid; Kynurenine 3-Monooxygenase; Male; Microdialysis; Mixed Function Oxygenases; N-Methylaspartate; Neurons; Pyruvates; Rats; Rats, Sprague-Dawley | 1999 |
Slow NMDA-EPSCs at synapses critical for song development are not required for song learning in zebra finches.
Topics: Acoustic Stimulation; Aging; Animals; Electrophysiology; Excitatory Postsynaptic Potentials; Hearing Loss, Noise-Induced; In Vitro Techniques; Kinetics; Learning; Male; N-Methylaspartate; Prosencephalon; Social Isolation; Songbirds; Synapses; Testosterone; Time Factors; Vocalization, Animal | 2000 |
Age-related decline in the functional response of striatal group I mGlu receptors.
Topics: Aging; Animals; Dopamine; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glycine; Hydrolysis; Male; Microdialysis; N-Methylaspartate; Neostriatum; Neurons; Phosphatidylinositols; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Resorcinols | 2000 |
Glutamatergic regulation of gonadotropin releasing hormone mRNA levels during development in the mouse.
Topics: 2-Amino-5-phosphonovalerate; Aging; Animals; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamates; Gonadotropin-Releasing Hormone; Male; Mice; Mice, Inbred C3H; N-Methylaspartate; Neurons; Prosencephalon; RNA, Messenger | 2000 |
NOC/oFQ contributes to age-dependent impairment of NMDA-induced cerebrovasodilation after brain injury.
Topics: Aging; Animals; Animals, Newborn; Arterioles; Blood Pressure; Brain Injuries; Cerebrovascular Circulation; Disease Models, Animal; Excitatory Amino Acids; Female; Glutamic Acid; Male; N-Methylaspartate; Narcotic Antagonists; Nociceptin; Nociceptin Receptor; Opioid Peptides; Peptide Fragments; Pia Mater; Receptors, Opioid; Swine; Vasoconstriction; Vasodilation; Wounds, Nonpenetrating | 2000 |
Neuroendocrine aging in the female rat: the changing relationship of hypothalamic gonadotropin-releasing hormone neurons and N-methyl-D-aspartate receptors.
Topics: Aging; Animals; Estradiol; Female; Gene Expression; Gonadotropin-Releasing Hormone; Hypothalamus; Hypothalamus, Anterior; Hypothalamus, Middle; N-Methylaspartate; Neurons; Preoptic Area; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reproduction; RNA, Messenger | 2000 |
Maturation of vulnerability to excitotoxicity: intracellular mechanisms in cultured postnatal hippocampal neurons.
Topics: Aging; Animals; Animals, Newborn; Biomarkers; Calcium; Cell Survival; Cells, Cultured; Drug Resistance; Electrophysiology; Excitatory Amino Acid Agonists; Hippocampus; Homeostasis; Intracellular Membranes; Membrane Potentials; Mitochondria; N-Methylaspartate; Neurons; Neurotoxins; Osmolar Concentration; Oxygen; Pyramidal Cells; Rats; Rats, Sprague-Dawley | 2000 |
NMDA receptor activation in the aged rat hippocampus.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; Animals; Electrophysiology; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Hippocampus; In Vitro Techniques; Magnesium; Male; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synapses; Time Factors | 2000 |
Delayed and isoform-specific effect of NMDA exposure on neural cell adhesion molecules in hippocampus.
Topics: Aging; Animals; Hippocampus; N-Methylaspartate; Neural Cell Adhesion Molecules; Organ Culture Techniques; Protein Isoforms; Rats; Time Factors | 2001 |
Altered responsiveness to stress and NMDA following prenatal exposure to cocaine.
Topics: Aging; Animals; Behavior, Animal; Cocaine; Cold Temperature; Corticosterone; Dopamine Uptake Inhibitors; Excitatory Amino Acid Agonists; Female; Immobilization; Male; N-Methylaspartate; Pain Measurement; Physical Endurance; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Stress, Psychological; Swimming | 2001 |
Effect of amyloid beta peptide on poly(ADP-ribose) polymerase activity in adult and aged rat hippocampus.
Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Animals; Cerebral Cortex; DNA Damage; Free Radicals; Hippocampus; Humans; N-Methylaspartate; Nerve Degeneration; Nitric Oxide; Peptide Fragments; Poly(ADP-ribose) Polymerases; Rats; Rats, Wistar | 2000 |
MAP2 phosphorylation and visual plasticity in Xenopus.
Topics: Aging; Animals; Dendrites; Dose-Response Relationship, Drug; Drug Administration Schedule; Excitatory Amino Acid Agonists; Glutamic Acid; Immunoblotting; Microtubule-Associated Proteins; N-Methylaspartate; Neuronal Plasticity; Phosphorylation; Receptors, N-Methyl-D-Aspartate; Superior Colliculi; Valine; Vision, Binocular; Visual Pathways; Xenopus laevis | 2001 |
Glutamate inhibition of NMDA-induced hydroxyl radical release: an ontogenic study in rat.
Topics: Aging; Animals; Animals, Newborn; Brain; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Hydroxyl Radical; Microdialysis; N-Methylaspartate; Neurons; Neurotoxins; Oxidative Stress; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Resorcinols; Salicylates | 2001 |
Age-Dependent vasopressinergic modulation of Noc/oFQ-induced impairment of NMDA cerebrovasodilation after brain injury.
Topics: Aging; Animals; Animals, Newborn; Blood Gas Analysis; Blood Pressure; Brain Injuries; Cerebrovascular Circulation; Excitatory Amino Acid Agonists; Female; Male; N-Methylaspartate; Nociceptin; Opioid Peptides; Receptors, N-Methyl-D-Aspartate; Swine; Vasodilation; Vasodilator Agents; Vasopressins | 2001 |
Developmental depression of glutamate neurotransmission by chronic low-level activation of NMDA receptors.
Topics: Aging; Animals; Animals, Newborn; Down-Regulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; GABA-A Receptor Antagonists; Glutamic Acid; In Vitro Techniques; Magnesium; N-Methylaspartate; Neural Inhibition; Neurons; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, GABA-A; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Superior Colliculi; Synapses; Synaptic Transmission | 2001 |
Age-related differences in NMDA responses in cultured rat hippocampal neurons.
Topics: Aging; Animals; Calcium; Cell Differentiation; Cell Membrane; Cells, Cultured; Female; Fetus; Hippocampus; Intracellular Fluid; Ion Channels; Membrane Potentials; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Pregnancy; Rats; Rats, Inbred F344; Reaction Time; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 2001 |
Characterization of the single-channel properties of NMDA receptors in laminae I and II of the dorsal horn of neonatal rat spinal cord.
Topics: Aging; Animals; Excitatory Amino Acid Antagonists; Ion Channels; Magnesium; Membrane Potentials; N-Methylaspartate; Nociceptors; Pain; Patch-Clamp Techniques; Piperidines; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 2001 |
Glial expression of small heat shock proteins following an excitotoxic lesion in the immature rat brain.
Topics: Aging; Animals; Astrocytes; Brain; Brain Injuries; Cerebral Cortex; Female; Glial Fibrillary Acidic Protein; Gliosis; Heat-Shock Proteins; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; HSP27 Heat-Shock Proteins; HSP47 Heat-Shock Proteins; Macrophages; Male; Microglia; N-Methylaspartate; Neoplasm Proteins; Nerve Degeneration; Neuroglia; Rats; Rats, Long-Evans; Stress, Physiological; Thalamus; Up-Regulation | 2002 |
Electrophysiological characterization of retinal Müller glial cells from mouse during postnatal development: comparison with rabbit cells.
Topics: Aging; Animals; Animals, Newborn; Barium; Cell Differentiation; Cell Membrane; Electric Stimulation; Excitatory Amino Acid Transporter 2; Female; Glutamic Acid; Ion Channels; Male; Membrane Potentials; Mice; N-Methylaspartate; Neuroglia; Potassium Channels; Rabbits; Receptors, N-Methyl-D-Aspartate; Retina; Sodium Channels | 2002 |
Single-electrode voltage-clamp analysis of the N-methyl-D-aspartate component of synaptic responses in neocortical slices from children with intractable epilepsy.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Adolescent; Aging; Bicuculline; Cerebral Cortex; Child; Child, Preschool; Electric Stimulation; Electrophysiology; Epilepsy; Evoked Potentials; Female; Humans; Infant; Male; Membrane Potentials; Microelectrodes; N-Methylaspartate; Neurons; Quinoxalines; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission | 1992 |
The effect of visual experience on development of NMDA receptor synaptic transmission in kitten visual cortex.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; Animals; Cats; Darkness; Evoked Potentials; Iontophoresis; Light; N-Methylaspartate; Photic Stimulation; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission; Vision, Ocular; Visual Cortex; Visual Perception | 1992 |
Cortical AMPA receptors: age-dependent regulation by cellular depolarization and agonist stimulation.
Topics: Aging; Animals; Cerebral Cortex; Glutamates; Glutamic Acid; Kainic Acid; Male; Membrane Potentials; Muscimol; N-Methylaspartate; Neuronal Plasticity; Quisqualic Acid; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Amino Acid; Receptors, AMPA; Receptors, Neurotransmitter; Veratridine | 1992 |
Kindling enhances sensitivity of CA3 hippocampal pyramidal cells to NMDA.
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Glutamates; Glutamic Acid; Hippocampus; Ibotenic Acid; In Vitro Techniques; Kindling, Neurologic; Magnesium; Male; N-Methylaspartate; Neurons; Rats; Rats, Inbred Strains | 1992 |
Susceptibility of brain to AMPA induced excitotoxicity transiently peaks during early postnatal development.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analysis of Variance; Animals; Brain; Brain Injuries; Diazepam; Dizocilpine Maleate; Female; Ibotenic Acid; Male; N-Methylaspartate; Neurotoxins; Organ Specificity; Phenytoin; Quinoxalines; Quisqualic Acid; Rats; Rats, Inbred Strains; Seizures | 1992 |
Modulation of NMDA receptors by ACh in the central nervous system.
Topics: Acetylcholine; Aging; Animals; Central Nervous System; Electrophysiology; In Vitro Techniques; Ion Channels; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Substantia Innominata | 1992 |
Effects of the N-methyl-D-aspartate antagonists on the rise in [Ca2+]i following depolarization in aged rat brain synaptosomes.
Topics: Aging; Animals; Brain; Calcium; Dextrorphan; Dizocilpine Maleate; Fluorescent Dyes; Heterocyclic Compounds, 3-Ring; Magnesium; Male; Membrane Potentials; N-Methylaspartate; Potassium; Rats; Rats, Inbred F344; Receptors, N-Methyl-D-Aspartate; Spectrometry, Fluorescence; Synaptosomes; Time Factors | 1992 |
Age-related anticonvulsant activity of NMDA in the rat caudate-putamen.
Topics: Aging; Animals; Anticonvulsants; Bicuculline; Caudate Nucleus; Female; Male; N-Methylaspartate; Putamen; Rats; Rats, Inbred Strains; Seizures; Stereotaxic Techniques | 1992 |
Evaluation of learning and memory mechanisms employing elevated plus-maze in rats and mice.
Topics: Aging; Animals; Dizocilpine Maleate; Electroshock; Female; Learning; Male; Memory; Mice; N-Methylaspartate; Physostigmine; Rats; Rats, Inbred Strains; Scopolamine | 1992 |
N-methyl-D-aspartate (NMDA)-induced seizures in developing rats.
Topics: Aging; Animals; Electroencephalography; Injections, Intraperitoneal; Male; Motor Activity; N-Methylaspartate; Rats; Seizures | 1992 |
The effects of N-methyl-D-aspartate antagonism on the inspiratory activities of developing animals.
Topics: Aging; Animals; Cats; Decerebrate State; Dizocilpine Maleate; Female; Hypoglossal Nerve; Male; N-Methylaspartate; Phrenic Nerve; Respiration; Stereotaxic Techniques | 1992 |
Age-related changes in NMDA-induced [3H]acetylcholine release from brain slices of senescence-accelerated mouse.
Topics: Acetylcholine; Aging; Animals; Brain Chemistry; Calcium; Choline; Hemicholinium 3; In Vitro Techniques; Magnesium; Mice; Mice, Inbred Strains; N-Methylaspartate; Potassium Chloride | 1992 |
Transient postnatal increases in excitatory amino acid binding sites in rat ventral mesencephalon.
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cell Membrane; Corpus Striatum; Glutamates; Ibotenic Acid; Kainic Acid; Mesencephalon; N-Methylaspartate; Organ Specificity; Rats; Rats, Inbred Strains; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1991 |
N-methyl-D-aspartate and aspartate raise the cytosolic free calcium concentration by acting upon receptors transiently expressed on immature cerebellar Purkinje cells.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; Animals; Animals, Newborn; Aspartic Acid; Calcium; Cerebellum; Cytosol; Gallopamil; gamma-Aminobutyric Acid; Glycine; In Vitro Techniques; Magnesium; N-Methylaspartate; Organophosphorus Compounds; Piperazines; Purkinje Cells; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 1991 |
Development of intracellular calcium responses to depolarization and to kainate and N-methyl-D-aspartate in cultured mouse hippocampal neurons.
Topics: Aging; Animals; Calcium; Cells, Cultured; Hippocampus; Image Processing, Computer-Assisted; Kainic Acid; Magnesium; Membrane Potentials; Mice; Microscopy, Fluorescence; N-Methylaspartate; Neurons; Video Recording | 1991 |
The action of clonazepam against seizures induced by N-methyl-D-aspartate in rats during ontogenesis.
Topics: Aging; Animals; Clonazepam; Epilepsy; Male; N-Methylaspartate; Rats; Rats, Inbred Strains | 1991 |
Initial expression and endogenous activation of NMDA channels in early neocortical development.
Topics: Aging; Animals; Animals, Newborn; Cerebral Cortex; Gestational Age; Glycine; Magnesium; N-Methylaspartate; Neurons; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 1991 |
Rapid alteration of synaptic number and postsynaptic thickening length by NMDA: an electron microscopic study in the occipital cortex of postnatal rats.
Topics: Aging; Animals; Lethal Dose 50; Male; Microscopy, Electron; N-Methylaspartate; Neuronal Plasticity; Neurons; Occipital Lobe; Rats; Receptors, N-Methyl-D-Aspartate; Synapses | 1991 |
NMDA induces protein kinase C translocation in hippocampal slices of immature rat brain.
Topics: Aging; Animals; Animals, Newborn; Biological Transport; Cell Membrane; Chemical Fractionation; Cytosol; Hippocampus; Immunoblotting; In Vitro Techniques; N-Methylaspartate; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats | 1991 |
Iontophoretic application of NMDA produces different types of excitatory responses in developing human cortical and caudate neurons.
Topics: Adolescent; Aging; Caudate Nucleus; Cerebral Cortex; Child; Child, Preschool; Electrophysiology; Humans; In Vitro Techniques; Infant; Iontophoresis; N-Methylaspartate; Neurons | 1991 |
Influence of age on N-methyl-D-aspartate antagonist binding sites in the rat brain studied by in vitro autoradiography.
Topics: Aging; Animals; Autoradiography; Brain; Brain Chemistry; In Vitro Techniques; Kinetics; Male; N-Methylaspartate; Piperazines; Rats; Rats, Inbred F344; Receptors, Drug | 1991 |
Developmental study of [3H]TCP and [3H]glycine binding sites in the rat hippocampus.
Topics: Aging; Animals; Autoradiography; Hippocampus; In Vitro Techniques; Kinetics; Magnesium; N-Methylaspartate; Nerve Tissue Proteins; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Strychnine | 1990 |
Development and regulation of excitatory amino acid receptors involved in the release of arachidonic acid in cultured hippocampal neural cells.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Arachidonic Acid; Arachidonic Acids; Astrocytes; Cells, Cultured; Female; Hippocampus; Ibotenic Acid; N-Methylaspartate; Neurons; Pregnancy; Quinoxalines; Quisqualic Acid; Rats; Receptors, Amino Acid; Receptors, Cell Surface | 1990 |
Changes in seizure activity of the neocortex during the early postnatal development of the rat: an electrophysiological study on slices in Mg(2+)-free medium.
Topics: Aging; Animals; Cerebral Cortex; Culture Media; Electrodes; Electrophysiology; In Vitro Techniques; Ketamine; Magnesium; N-Methylaspartate; Perfusion; Rats; Seizures; Somatosensory Cortex | 1991 |
Expression of c-fos protein by N-methyl-D-aspartic acid in hypothalamus of immature female rats: blockade by MK-801 or neonatal treatment with monosodium glutamate.
Topics: Aging; Animals; Animals, Newborn; Arcuate Nucleus of Hypothalamus; Dizocilpine Maleate; Female; Gene Expression; Hypothalamus; Median Eminence; N-Methylaspartate; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; Rats; Reference Values; Sodium Glutamate | 1990 |
Role of hypothalamic factors (growth-hormone-releasing hormone and gamma-aminobutyric acid) in the regulation of growth hormone secretion in the neonatal and adult rat.
Topics: Aging; Animals; Animals, Newborn; Female; gamma-Aminobutyric Acid; Growth Hormone; Growth Hormone-Releasing Hormone; Hypothalamus; Male; N-Methylaspartate; Rats; Rats, Inbred Strains | 1990 |
The allosteric glycine site of the N-methyl-D-aspartate receptor modulates GABAergic-mediated synaptic events in neonatal rat CA3 hippocampal neurons.
Topics: Aging; Allosteric Regulation; Allosteric Site; Animals; Animals, Newborn; Aspartic Acid; Electric Conductivity; Female; gamma-Aminobutyric Acid; Glycine; Hippocampus; In Vitro Techniques; Male; Membrane Potentials; N-Methylaspartate; Neurons; Pyramidal Tracts; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Serine; Synapses; Tetrodotoxin | 1990 |
Changes in excitatory amino acid modulation of phosphoinositide metabolism during development.
Topics: Aging; Animals; Aspartic Acid; Brain; Inositol Phosphates; N-Methylaspartate; Oxadiazoles; Phosphatidylinositols; Quisqualic Acid; Rats; Receptors, Amino Acid; Receptors, Cell Surface | 1990 |
Excitatory amino acid receptors on sustained retinal ganglion cells in the kitten during the critical period of development.
Topics: Action Potentials; Aging; Animals; Aspartic Acid; Cats; Kainic Acid; N-Methylaspartate; Oxadiazoles; Photic Stimulation; Quisqualic Acid; Receptors, Amino Acid; Receptors, Cell Surface; Retina; Retinal Ganglion Cells; Visual Pathways | 1990 |
Maturation of the hypothalamic control of pulsatile gonadotropin-releasing hormone secretion at onset of puberty. I. Increased activation of N-methyl-D-aspartate receptors.
Topics: Aging; Animals; Anticonvulsants; Aspartic Acid; Dibenzocycloheptenes; Dizocilpine Maleate; Gonadotropin-Releasing Hormone; Hypothalamo-Hypophyseal System; Hypothalamus; Kinetics; Magnesium; Male; N-Methylaspartate; Organ Culture Techniques; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Sexual Maturation; Spermatids; Testis | 1990 |
Excitatory amino acid-induced convulsions in neonatal rats mediated by distinct receptor subtypes.
Topics: Aging; Amino Acids; Animals; Animals, Newborn; Anticonvulsants; Convulsants; Female; Male; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Seizures | 1990 |
Age-related changes in uptake and release on L-[3H]noradrenaline in brain slices of senescence accelerated mouse.
Topics: Aging; Animals; Aspartic Acid; Biological Transport; Brain; In Vitro Techniques; Male; Mice; Mice, Inbred Strains; N-Methylaspartate; Norepinephrine; Potassium Chloride | 1990 |
NMDA depolarizations and long-term potentiation are reduced in the aged rat neocortex.
Topics: Aging; Alzheimer Disease; Animals; Cerebral Cortex; Disease Models, Animal; Electric Stimulation; In Vitro Techniques; Membrane Potentials; N-Methylaspartate; Neurons; Rats; Rats, Inbred F344; Time Factors | 1990 |
N-methyl-aspartic acid lesions of the arcuate nucleus in adult C57BL/6J mice: a new model for age-related lengthening of the estrous cycle.
Topics: Aging; Animals; Arcuate Nucleus of Hypothalamus; Aspartic Acid; Biogenic Monoamines; Body Weight; Estrogens; Estrus; Female; Hypothalamus; Injections, Subcutaneous; Mice; Mice, Inbred C57BL; Models, Biological; N-Methylaspartate | 1989 |
Anoxia on slow inward currents of immature hippocampal neurons.
Topics: Aging; Animals; Animals, Newborn; Aspartic Acid; Calcium Channels; Electric Conductivity; Hippocampus; Hypoxia; Membrane Potentials; N-Methylaspartate; Neurons; Rats; Rats, Inbred Strains | 1989 |
Transient increase of NMDA-binding sites in human hippocampus during development.
Topics: Adult; Aging; Aspartic Acid; Fetus; Glutamates; Glutamic Acid; Hippocampus; Humans; Infant; Infant, Newborn; Middle Aged; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
Developmental changes in the chemosensitivity of rat brain synaptoneurosomes to excitatory amino acids, estimated by inositol phosphate formation.
Topics: Aging; Animals; Aspartic Acid; Carbachol; Female; Frontal Lobe; Glutamates; Glutamic Acid; Inositol Phosphates; Male; N-Methylaspartate; Norepinephrine; Oxadiazoles; Quisqualic Acid; Rats; Sugar Phosphates; Synaptosomes | 1989 |
A biochemical correlate of the critical period for synaptic modification in the visual cortex.
Topics: Aging; Animals; Aspartic Acid; Carbachol; Cattle; Glutamates; Glutamic Acid; Ibotenic Acid; N-Methylaspartate; Ocular Physiological Phenomena; Phosphatidylinositols; Synapses; Vision, Ocular; Visual Cortex | 1989 |
Transient increased density of NMDA binding sites in the developing rat hippocampus.
Topics: Aging; Animals; Aspartic Acid; Autoradiography; Binding, Competitive; Glutamates; Glutamic Acid; Hippocampus; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1988 |
In vitro neurotoxicity of excitatory acid analogues during cerebellar development.
Topics: Aging; Animals; Aspartic Acid; Cerebellum; Female; In Vitro Techniques; Kainic Acid; Male; N-Methylaspartate; Neurotoxins; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Tetrodotoxin | 1986 |
Neurotoxicity of N-methyl-D-aspartate is markedly enhanced in developing rat central nervous system.
Topics: Aging; Animals; Aspartic Acid; Corpus Striatum; Hippocampus; Microinjections; N-Methylaspartate; Neurotoxins; Rats; Rats, Inbred Strains; Seizures | 1988 |
Changes in voltage dependence of NMDA currents during development.
Topics: Aging; Animals; Aspartic Acid; Electric Conductivity; Hippocampus; In Vitro Techniques; Membrane Potentials; N-Methylaspartate; Neurons; Rats; Rats, Inbred Strains | 1988 |
Developmental changes in neuronal sensitivity to excitatory amino acids in area CA1 of the rat hippocampus.
Topics: Action Potentials; Aging; Animals; Aspartic Acid; Electric Stimulation; Hippocampus; In Vitro Techniques; Male; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains | 1988 |
Characterization and possible opioid modulation of N-methyl-D-aspartic acid induced increases in serum luteinizing hormone levels in the developing male rat.
Topics: Aging; Animals; Aspartic Acid; Endorphins; Gonadotropin-Releasing Hormone; Hypothalamus; Luteinizing Hormone; Morphine; N-Methylaspartate; Naloxone; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains | 1988 |
Selective loss of Purkinje and granule cell responsiveness to N-methyl-D-aspartate in rat cerebellum during development.
Topics: Aging; Animals; Aspartic Acid; Cerebellum; Convulsants; In Vitro Techniques; Kainic Acid; Membrane Potentials; N-Methylaspartate; Neurons; Oxadiazoles; Purkinje Cells; Quisqualic Acid; Rats | 1987 |
Ketamine selectively suppresses synchronized afterdischarges in immature hippocampus.
Topics: Aging; Animals; Aspartic Acid; Evoked Potentials; Hippocampus; Iontophoresis; Ketamine; Membrane Potentials; N-Methylaspartate; Neural Inhibition; Neurons; Penicillins; Rats | 1986 |