n-methyl-3,4-methylenedioxyamphetamine has been researched along with Substance Withdrawal Syndrome in 47 studies
N-Methyl-3,4-methylenedioxyamphetamine: An N-substituted amphetamine analog. It is a widely abused drug classified as a hallucinogen and causes marked, long-lasting changes in brain serotonergic systems. It is commonly referred to as MDMA or ecstasy.
3,4-methylenedioxymethamphetamine : A member of the class of benzodioxoles that is 1,3-benzodioxole substituted by a 2-(methylamino)propyl group at position 5.
Substance Withdrawal Syndrome: Physiological and psychological symptoms associated with withdrawal from the use of a drug after prolonged administration or habituation. The concept includes withdrawal from smoking or drinking, as well as withdrawal from an administered drug.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Oxytocin therefore has fascinating potential to reverse the corrosive effects of long-term drugs abuse on social behavior and to perhaps inoculate against future vulnerability to addictive disorders." | 2.48 | Breaking the loop: oxytocin as a potential treatment for drug addiction. ( Bowen, MT; McGregor, IS, 2012) |
| " Locomotor activity and body weight were assessed during the dosing period and withdrawal-related anxiety was assessed 24 h after drug cessation." | 1.36 | Residual social, memory and oxytocin-related changes in rats following repeated exposure to γ-hydroxybutyrate (GHB), 3,4-methylenedioxymethamphetamine (MDMA) or their combination. ( Arnold, JC; Hunt, GE; Long, LE; McGregor, IS; van Nieuwenhuijzen, PS, 2010) |
| "The computerized Substance Abuse Module for Club Drug (CD-SAM) was used to assess MDMA abuse and dependence." | 1.35 | Test-re-test reliability of DSM-IV adopted criteria for 3,4-methylenedioxymethamphetamine (MDMA) abuse and dependence: a cross-national study. ( Abdallah, AB; Cottler, LB; Leung, KS, 2009) |
| "The aim of this study was the assessment of disorders after chronic intake of psychoactive drugs, like marijuana, amphetamine, ecstasy, cocaine and opiates." | 1.32 | [Assessment of disorders after chronic psychoactive drug abuse in patients hospitalized in detoxification units]. ( Chrostek Maj, J; Kamenczak, A; Kroch, S; Polewka, A; Szerszeń-Motyka, J, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (4.26) | 18.2507 |
| 2000's | 32 (68.09) | 29.6817 |
| 2010's | 10 (21.28) | 24.3611 |
| 2020's | 3 (6.38) | 2.80 |
| Authors | Studies |
|---|---|
| Belouin, SJ | 1 |
| Averill, LA | 1 |
| Henningfield, JE | 1 |
| Xenakis, SN | 1 |
| Donato, I | 1 |
| Grob, CS | 1 |
| Berger, A | 1 |
| Magar, V | 1 |
| Danforth, AL | 1 |
| Anderson, BT | 1 |
| Jones, G | 1 |
| Lipson, J | 1 |
| Wang, E | 1 |
| Ponzoni, L | 1 |
| Teh, MT | 1 |
| Torres-Perez, JV | 1 |
| Brennan, CH | 1 |
| Braida, D | 1 |
| Sala, M | 1 |
| Highgate, Q | 1 |
| Schenk, S | 1 |
| Downey, LA | 1 |
| Loftis, JM | 1 |
| McKetin, R | 1 |
| Copeland, J | 1 |
| Norberg, MM | 1 |
| Bruno, R | 1 |
| Hides, L | 1 |
| Khawar, L | 1 |
| Carhart-Harris, RL | 1 |
| Nutt, DJ | 1 |
| Munafò, M | 1 |
| Wilson, SJ | 1 |
| Orejarena, MJ | 1 |
| Berrendero, F | 1 |
| Maldonado, R | 2 |
| Robledo, P | 1 |
| Cottler, LB | 1 |
| Leung, KS | 1 |
| Abdallah, AB | 1 |
| Nawata, Y | 1 |
| Hiranita, T | 1 |
| Yamamoto, T | 1 |
| Naito, H | 1 |
| van Nieuwenhuijzen, PS | 1 |
| Long, LE | 1 |
| Hunt, GE | 2 |
| Arnold, JC | 1 |
| McGregor, IS | 3 |
| Bousman, CA | 1 |
| Cherner, M | 1 |
| Emory, KT | 1 |
| Barron, D | 1 |
| Grebenstein, P | 1 |
| Atkinson, JH | 1 |
| Heaton, RK | 1 |
| Grant, I | 1 |
| Fogger, SA | 1 |
| McCann, UD | 2 |
| Edwards, RR | 1 |
| Smith, MT | 1 |
| Kelley, K | 1 |
| Wilson, M | 1 |
| Sgambati, F | 1 |
| Ricaurte, G | 1 |
| Bowen, MT | 1 |
| MacInnes, N | 2 |
| Handley, SL | 2 |
| Harding, GF | 2 |
| Lingford-Hughes, A | 1 |
| Nutt, D | 1 |
| Satsumi, YN | 1 |
| Bull, EJ | 1 |
| Hutson, PH | 1 |
| Fone, KC | 1 |
| Achat-Mendes, C | 1 |
| Anderson, KL | 1 |
| Itzhak, Y | 1 |
| Soar, K | 1 |
| Parrott, AC | 1 |
| Fox, HC | 1 |
| Chrostek Maj, J | 1 |
| Kroch, S | 1 |
| Kamenczak, A | 1 |
| Polewka, A | 1 |
| Szerszeń-Motyka, J | 1 |
| Bryant, SM | 1 |
| Kolodchak, J | 1 |
| Kuypers, KP | 1 |
| Ramaekers, JG | 1 |
| Carmondy, J | 1 |
| Delanty, N | 1 |
| Thomasius, R | 1 |
| Zapletalova, P | 1 |
| Petersen, K | 1 |
| Buchert, R | 1 |
| Andresen, B | 1 |
| Wartberg, L | 1 |
| Nebeling, B | 1 |
| Schmoldt, A | 1 |
| Huxster, JK | 1 |
| Pirona, A | 1 |
| Morgan, MJ | 2 |
| Hoshi, R | 3 |
| Pratt, H | 1 |
| Mehta, S | 1 |
| Bond, AJ | 1 |
| Curran, HV | 3 |
| Quednow, BB | 1 |
| Jessen, F | 1 |
| Kuhn, KU | 1 |
| Maier, W | 1 |
| Daum, I | 1 |
| Wagner, M | 1 |
| Reneman, L | 1 |
| Schilt, T | 1 |
| de Win, MM | 1 |
| Booij, J | 1 |
| Schmand, B | 1 |
| van den Brink, W | 1 |
| Bakker, O | 1 |
| Ward, J | 1 |
| Hall, K | 1 |
| Haslam, C | 1 |
| Dalley, JW | 1 |
| Lääne, K | 1 |
| Theobald, DE | 1 |
| Peña, Y | 1 |
| Bruce, CC | 1 |
| Huszar, AC | 1 |
| Wojcieszek, M | 1 |
| Everitt, BJ | 1 |
| Robbins, TW | 1 |
| Peterson, SC | 1 |
| Ricaurte, GA | 1 |
| Touriño, C | 1 |
| Valverde, O | 1 |
| Groth-Marnat, G | 1 |
| Howchar, H | 1 |
| Marsh, A | 1 |
| Mullins, K | 1 |
| Boundy, C | 1 |
| Brignell, C | 1 |
| Piccini, P | 2 |
| Cohen, L | 1 |
| Lemanski, L | 1 |
| Bond, A | 1 |
| Marchesi, C | 1 |
| Tonna, M | 1 |
| Maggini, C | 1 |
| Schierenbeck, T | 1 |
| Riemann, D | 1 |
| Berger, M | 1 |
| Hornyak, M | 1 |
| Callaghan, PD | 1 |
| Gouzoulis-Mayfrank, E | 2 |
| Hermle, L | 1 |
| Kovar, KA | 1 |
| Sass, H | 2 |
| Daumann, J | 1 |
| Tuchtenhagen, F | 1 |
| Pelz, S | 1 |
| Becker, S | 1 |
| Kunert, HJ | 1 |
| Fimm, B | 1 |
| Gervin, M | 1 |
| Hughes, R | 1 |
| Bamford, L | 1 |
| Smyth, BP | 1 |
| Keenan, E | 1 |
| McFie, L | 1 |
| Fleetwood, H | 1 |
| Robinson, JA | 1 |
| Pallanti, S | 1 |
| Mazzi, D | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Oxytocin in Alcohol Use Disorder: A Novel and Translational Approach[NCT02711189] | Phase 1 | 0 participants (Actual) | Interventional | 2016-03-08 | Withdrawn | ||
| The Effects of MDMA on Prefrontal and Amygdala Activation in Posttraumatic Stress Disorder[NCT03752918] | Phase 1 | 20 participants (Anticipated) | Interventional | 2024-01-31 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
10 reviews available for n-methyl-3,4-methylenedioxyamphetamine and Substance Withdrawal Syndrome
| Article | Year |
|---|---|
Policy considerations that support equitable access to responsible, accountable, safe, and ethical uses of psychedelic medicines.
Topics: Hallucinogens; Humans; N-Methyl-3,4-methylenedioxyamphetamine; Policy; Psilocybin; Substance Withdra | 2022 |
Altered energy production, lowered antioxidant potential, and inflammatory processes mediate CNS damage associated with abuse of the psychostimulants MDMA and methamphetamine.
Topics: Amphetamine-Related Disorders; Animals; Brain; Central Nervous System Stimulants; Energy Metabolism; | 2014 |
[Entactogen and designer drugs (2)].
Topics: Animals; Central Nervous System Stimulants; Designer Drugs; Drug Interactions; Humans; Mental Disord | 2010 |
Breaking the loop: oxytocin as a potential treatment for drug addiction.
Topics: Adaptation, Psychological; Alcoholism; Animals; Drug Tolerance; Hallucinogens; Humans; N-Methyl-3,4- | 2012 |
Neurobiology of addiction and implications for treatment.
Topics: Behavior, Addictive; Dopamine; Heroin Dependence; Humans; N-Methyl-3,4-methylenedioxyamphetamine; Ne | 2003 |
[Recent abuse of 3,4-methylenedioxymethamphetamine ("yaoto-wang", "ecstasy")].
Topics: Adolescent; Adult; Age Factors; Animals; Central Nervous System; Humans; Japan; N-Methyl-3,4-methyle | 2002 |
Mood, cognition and serotonin transporter availability in current and former ecstasy (MDMA) users: the longitudinal perspective.
Topics: Affect; Amphetamine-Related Disorders; Brain; Cognition Disorders; Cross-Sectional Studies; Dose-Res | 2006 |
Effect of illicit recreational drugs upon sleep: cocaine, ecstasy and marijuana.
Topics: Animals; Brain; Cocaine; Disease Models, Animal; Dronabinol; Humans; Illicit Drugs; N-Methyl-3,4-met | 2008 |
From ultrasocial to antisocial: a role for oxytocin in the acute reinforcing effects and long-term adverse consequences of drug use?
Topics: Adaptation, Physiological; Adaptation, Psychological; Amphetamine-Related Disorders; Animals; Behavi | 2008 |
[Entactogenic drugs "ecstasy" (MDMA), "eve" (MDE) and other ring-substituted methamphetamine derivatives. A new class of substances among illegal designer drugs?].
Topics: 3,4-Methylenedioxyamphetamine; Animals; Designer Drugs; Humans; N-Methyl-3,4-methylenedioxyamphetami | 1996 |
4 trials available for n-methyl-3,4-methylenedioxyamphetamine and Substance Withdrawal Syndrome
| Article | Year |
|---|---|
Altered pain responses in abstinent (±)3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") users.
Topics: Adult; Brain; Female; Humans; Male; N-Methyl-3,4-methylenedioxyamphetamine; Neuropsychological Tests | 2011 |
Transient memory impairment after acute dose of 75mg 3.4-Methylene-dioxymethamphetamine.
Topics: Adult; Affect; Amphetamine-Related Disorders; Cross-Over Studies; Discrimination Learning; Double-Bl | 2005 |
The sub-acute effects of recreational ecstasy (MDMA) use: a controlled study in humans.
Topics: Adolescent; Adult; Affect; Amphetamine-Related Disorders; Cognition; Drug Interactions; Female; Hall | 2006 |
An investigation into the sub-acute effects of ecstasy on aggressive interpretative bias and aggressive mood - are there gender differences?
Topics: Adult; Affect; Aggression; Alcoholic Intoxication; Amphetamine-Related Disorders; Anxiety; Attention | 2006 |
33 other studies available for n-methyl-3,4-methylenedioxyamphetamine and Substance Withdrawal Syndrome
| Article | Year |
|---|---|
Examining associations between MDMA/ecstasy and classic psychedelic use and impairments in social functioning in a U.S. adult sample.
Topics: Adult; Hallucinogens; Humans; Mescaline; N-Methyl-3,4-methylenedioxyamphetamine; Psilocybin; Social | 2023 |
Increased Response to 3,4-Methylenedioxymethamphetamine (MDMA) Reward and Altered Gene Expression in Zebrafish During Short- and Long-Term Nicotine Withdrawal.
Topics: Animals; Conditioning, Classical; Female; Gene Expression Regulation; Male; N-Methyl-3,4-methylenedi | 2021 |
Comparison of the effects of abstinence on MDMA and cocaine self-administration in rats.
Topics: Adrenergic Uptake Inhibitors; Animals; Behavior, Addictive; Cocaine; Dopamine Uptake Inhibitors; Mal | 2018 |
The effect of the ecstasy 'come-down' on the diagnosis of ecstasy dependence.
Topics: Adolescent; Adult; Factor Analysis, Statistical; Female; Humans; Illicit Drugs; Interviews as Topic; | 2014 |
Current and former ecstasy users report different sleep to matched controls: a web-based questionnaire study.
Topics: Adolescent; Adult; Female; Hallucinogens; Humans; Illicit Drugs; Internet; Male; Middle Aged; N-Meth | 2009 |
Differential changes in mesolimbic dopamine following contingent and non-contingent MDMA self-administration in mice.
Topics: Amphetamine-Related Disorders; Animals; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dose- | 2009 |
Test-re-test reliability of DSM-IV adopted criteria for 3,4-methylenedioxymethamphetamine (MDMA) abuse and dependence: a cross-national study.
Topics: Adolescent; Adult; Australia; Diagnosis, Differential; Diagnostic and Statistical Manual of Mental D | 2009 |
A cannabinoid CB(1) receptor antagonist ameliorates impairment of recognition memory on withdrawal from MDMA (Ecstasy).
Topics: Analysis of Variance; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Admini | 2010 |
Residual social, memory and oxytocin-related changes in rats following repeated exposure to γ-hydroxybutyrate (GHB), 3,4-methylenedioxymethamphetamine (MDMA) or their combination.
Topics: Animals; Anxiety; Behavior, Animal; Biogenic Monoamines; Body Weight; Brain; Chromatography, High Pr | 2010 |
Preliminary evidence of motor impairment among polysubstance 3,4-methylenedioxymethamphetamine users with intact neuropsychological functioning.
Topics: Adult; Amphetamine-Related Disorders; Case-Control Studies; Female; Humans; Male; Movement Disorders | 2010 |
Update on ecstasy.
Topics: Adolescent; Adrenergic Uptake Inhibitors; Amphetamine-Related Disorders; Anxiety Disorders; Cognitio | 2011 |
The BDI of the beholder: an eye to experimental design.
Topics: Depression; Humans; N-Methyl-3,4-methylenedioxyamphetamine; Personality Inventory; Psychometrics; Ra | 2002 |
Reduced social interaction following 3,4-methylenedioxymethamphetamine is not associated with enhanced 5-HT 2C receptor responsivity.
Topics: Animals; Brain; Corticosterone; Exploratory Behavior; Hydroxyindoleacetic Acid; Hypothermia; In Vitr | 2003 |
Methylphenidate and MDMA adolescent exposure in mice: long-lasting consequences on cocaine-induced reward and psychomotor stimulation in adulthood.
Topics: Age Factors; Animals; Central Nervous System Stimulants; Cocaine; Conditioning, Psychological; Male; | 2003 |
Persistent neuropsychological problems after 7 years of abstinence from recreational Ecstasy (MDMA): a case study.
Topics: Adrenergic Uptake Inhibitors; Adult; Depressive Disorder; Erectile Dysfunction; Follow-Up Studies; H | 2004 |
[Assessment of disorders after chronic psychoactive drug abuse in patients hospitalized in detoxification units].
Topics: Adolescent; Adult; Amphetamine; Amphetamine-Related Disorders; Cannabis; Cocaine; Cocaine-Related Di | 2004 |
Serotonin syndrome resulting from an herbal detox cocktail.
Topics: Adult; Antidepressive Agents, Second-Generation; Humans; Hypericum; Male; N-Methyl-3,4-methylenediox | 2004 |
Juvenile myoclonic epilepsy masquerading as ecstasy withdrawal.
Topics: Adolescent; Anticonvulsants; Diagnosis, Differential; Female; Hallucinogens; Humans; Myoclonic Epile | 2005 |
Memory deficits in abstinent MDMA (ecstasy) users: neuropsychological evidence of frontal dysfunction.
Topics: Adult; Amphetamine-Related Disorders; Cannabinoids; Dose-Response Relationship, Drug; Frontal Lobe; | 2006 |
Memory function and serotonin transporter promoter gene polymorphism in ecstasy (MDMA) users.
Topics: Adult; Amphetamine-Related Disorders; Attention; Brain; Dose-Response Relationship, Drug; Female; Ge | 2006 |
Patterns of memory dysfunction in current and 2-year abstinent MDMA users.
Topics: Adult; Analysis of Variance; Demography; Female; Hallucinogens; Humans; Male; Memory Disorders; Memo | 2006 |
Enduring deficits in sustained visual attention during withdrawal of intravenous methylenedioxymethamphetamine self-administration in rats: results from a comparative study with d-amphetamine and methamphetamine.
Topics: Amphetamine-Related Disorders; Amphetamines; Animals; Attention; Attention Deficit Disorder with Hyp | 2007 |
The effect of catecholamine depletion by alpha-methyl-para-tyrosine on measures of cognitive performance and sleep in abstinent MDMA users.
Topics: Adult; alpha-Methyltyrosine; Analysis of Variance; Cognition; Computer-Assisted Instruction; Electro | 2007 |
MDMA attenuates THC withdrawal syndrome in mice.
Topics: Animals; Brain; Cannabinoid Receptor Antagonists; Dopamine; Dose-Response Relationship, Drug; Dronab | 2007 |
Memory performance in abstinent 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") users.
Topics: Adolescent; Adult; Amphetamine-Related Disorders; Cocaine; Cocaine-Related Disorders; Female; Humans | 2007 |
Neurocognitive function in current and ex-users of ecstasy in comparison to both matched polydrug-using controls and drug-naïve controls.
Topics: Adult; Case-Control Studies; Cognition Disorders; Hallucinogens; Humans; Illicit Drugs; Learning; Ma | 2007 |
Ecstasy (MDMA) does not have long-term effects on aggressive interpretative bias: a study comparing current and ex-ecstasy users with polydrug and drug-naive controls.
Topics: Adult; Affect; Aggression; Analysis of Variance; Bias; Employment; Female; Hallucinogens; Humans; Ma | 2007 |
Obsessive-compulsive disorder followed by psychotic episode in long-term ecstasy misuse.
Topics: Adolescent; Amphetamine-Related Disorders; Antidepressive Agents, Tricyclic; Antipsychotic Agents; B | 2009 |
Impaired cognitive performance in drug free users of recreational ecstasy (MDMA)
Topics: Adolescent; Adult; Attention; Cognition Disorders; Female; Hallucinogens; Humans; Intelligence; Lear | 2000 |
Former chronic methylenedioxymethamphetamine (MDMA or ecstasy) users report mild depressive symptoms.
Topics: Adult; Depression; Female; Humans; Internal-External Control; Life Change Events; Male; Motivation; | 2001 |
Heroin smoking by "chasing the dragon" in young opiate users in Ireland: stability and associations with use to "come down" off "Ecstasy".
Topics: Administration, Inhalation; Adolescent; Adult; Heroin; Heroin Dependence; Humans; Ireland; N-Methyl- | 2001 |
Ecstasy (MDMA): are the psychological problems associated with its use reversed by prolonged abstinence?
Topics: Adult; Analysis of Variance; Cognition Disorders; Female; Hallucinogens; Humans; Impulsive Behavior; | 2002 |
MDMA (Ecstasy) precipitation of panic disorder.
Topics: 3,4-Methylenedioxyamphetamine; Adult; Agoraphobia; Alcohol Drinking; Amitriptyline; Arousal; Fluvoxa | 1992 |