n-methyl-3,4-methylenedioxyamphetamine has been researched along with Serotonin Syndrome in 20 studies
N-Methyl-3,4-methylenedioxyamphetamine: An N-substituted amphetamine analog. It is a widely abused drug classified as a hallucinogen and causes marked, long-lasting changes in brain serotonergic systems. It is commonly referred to as MDMA or ecstasy.
3,4-methylenedioxymethamphetamine : A member of the class of benzodioxoles that is 1,3-benzodioxole substituted by a 2-(methylamino)propyl group at position 5.
Serotonin Syndrome: An adverse drug interaction characterized by altered mental status, autonomic dysfunction, and neuromuscular abnormalities. It is most frequently caused by use of both serotonin reuptake inhibitors and monoamine oxidase inhibitors, leading to excess serotonin availability in the CNS at the serotonin 1A receptor.
| Excerpt | Relevance | Reference |
|---|---|---|
| " blood pressure, heart rate, body temperature) can be reduced, possibly due to a pharmacodynamic interaction at the serotonin reuptake transporter (SERT)." | 2.48 | Pharmacokinetics and pharmacodynamics of 3,4-methylenedioxymethamphetamine (MDMA): interindividual differences due to polymorphisms and drug-drug interactions. ( Hondebrink, L; Meulenbelt, J; Rietjens, SJ; Westerink, RH, 2012) |
| " A mistaken belief that it is a safe drug of low toxicity and a long duration of action has led to its widespread popularity among teenagers and young adults in recent years." | 2.43 | [Ecstasy toxicity]. ( Reingardiene, D, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (10.00) | 18.2507 |
| 2000's | 10 (50.00) | 29.6817 |
| 2010's | 7 (35.00) | 24.3611 |
| 2020's | 1 (5.00) | 2.80 |
| Authors | Studies |
|---|---|
| Stilmant, AC | 1 |
| Zhu, L | 1 |
| Gorur, Y | 1 |
| Cardos, B | 1 |
| Yerna, M | 1 |
| Ali, D | 1 |
| Dobry, Y | 1 |
| Rice, T | 1 |
| Sher, L | 1 |
| Tao, R | 3 |
| Shokry, IM | 3 |
| Callanan, JJ | 3 |
| Adams, HD | 1 |
| Ma, Z | 1 |
| Sousa, J | 2 |
| Pilgrim, JL | 1 |
| Gerostamoulos, D | 1 |
| Woodford, N | 1 |
| Drummer, OH | 1 |
| Warrick, BJ | 1 |
| Wilson, J | 1 |
| Hedge, M | 1 |
| Freeman, S | 1 |
| Leonard, K | 1 |
| Aaron, C | 1 |
| Rietjens, SJ | 1 |
| Hondebrink, L | 1 |
| Westerink, RH | 1 |
| Meulenbelt, J | 1 |
| Arnold, DH | 1 |
| Vuori, E | 1 |
| Henry, JA | 1 |
| Ojanperä, I | 1 |
| Nieminen, R | 1 |
| Savolainen, T | 1 |
| Wahlsten, P | 1 |
| Jäntti, M | 1 |
| Bryant, SM | 1 |
| Kolodchak, J | 1 |
| Campbell, S | 1 |
| Qureshi, T | 1 |
| Morley, KC | 1 |
| Arnold, JC | 1 |
| McGregor, IS | 1 |
| Reingardiene, D | 1 |
| Izco, M | 1 |
| Orio, L | 1 |
| O'Shea, E | 1 |
| Colado, MI | 1 |
| Silins, E | 1 |
| Copeland, J | 1 |
| Dillon, P | 1 |
| Ozkardesler, S | 1 |
| Gurpinar, T | 1 |
| Akan, M | 1 |
| Koca, U | 1 |
| Sarikaya, H | 1 |
| Olmez, T | 1 |
| Elar, Z | 1 |
| Felgenhauer, N | 1 |
| Zilker, T | 1 |
| Shankaran, M | 1 |
| Gudelsky, GA | 1 |
| Parrott, AC | 1 |
6 reviews available for n-methyl-3,4-methylenedioxyamphetamine and Serotonin Syndrome
| Article | Year |
|---|---|
Ecstasy use and serotonin syndrome: a neglected danger to adolescents and young adults prescribed selective serotonin reuptake inhibitors.
Topics: Adolescent; Drug Interactions; Humans; Inappropriate Prescribing; Mental Disorders; N-Methyl-3,4-met | 2013 |
Pharmacokinetics and pharmacodynamics of 3,4-methylenedioxymethamphetamine (MDMA): interindividual differences due to polymorphisms and drug-drug interactions.
Topics: Animals; Blood Pressure; Body Temperature; Brain; Carbazoles; Carvedilol; Cytochrome P-450 CYP2D6; D | 2012 |
[Ecstasy toxicity].
Topics: Adolescent; Adult; Age Factors; Cardiovascular Diseases; Emergencies; Hallucinogens; Hospitalization | 2006 |
Qualitative review of serotonin syndrome, ecstasy (MDMA) and the use of other serotonergic substances: hierarchy of risk.
Topics: Humans; N-Methyl-3,4-methylenedioxyamphetamine; Risk Factors; Serotonin Agents; Serotonin Syndrome; | 2007 |
[Poisoning with amphetamines and designer drugs].
Topics: 3,4-Methylenedioxyamphetamine; Amphetamines; Designer Drugs; Drug Overdose; Humans; Illicit Drugs; I | 1999 |
Recreational Ecstasy/MDMA, the serotonin syndrome, and serotonergic neurotoxicity.
Topics: Animals; Cognition Disorders; Humans; Memory Disorders; N-Methyl-3,4-methylenedioxyamphetamine; Neur | 2002 |
14 other studies available for n-methyl-3,4-methylenedioxyamphetamine and Serotonin Syndrome
| Article | Year |
|---|---|
[Fatal serotonin syndrome induced by ecstasy consumption].
Topics: Adult; Emergency Service, Hospital; Fever; Humans; Male; N-Methyl-3,4-methylenedioxyamphetamine; Ser | 2022 |
Mechanisms and environmental factors that underlying the intensification of 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy)-induced serotonin syndrome in rats.
Topics: Animals; Dose-Response Relationship, Drug; Environment; Hot Temperature; Male; Maze Learning; Motor | 2015 |
Rapid In Situ Hybridization using Oligonucleotide Probes on Paraformaldehyde-prefixed Brain of Rats with Serotonin Syndrome.
Topics: Animals; Brain Chemistry; Cyclophilins; Dihydrodipicolinate Reductase; Fixatives; Formaldehyde; In S | 2015 |
New Insights on Different Response of MDMA-Elicited Serotonin Syndrome to Systemic and Intracranial Administrations in the Rat Brain.
Topics: Animals; Body Temperature; Brain; Drug Administration Routes; Male; Microdialysis; N-Methyl-3,4-meth | 2016 |
Serotonin toxicity involving MDMA (ecstasy) and moclobemide.
Topics: Adult; Coronary Artery Disease; Forensic Toxicology; Hallucinogens; Humans; Liver; Lung; Male; Middl | 2012 |
Lethal serotonin syndrome after methylone and butylone ingestion.
Topics: 3,4-Methylenedioxyamphetamine; Adult; Fatal Outcome; Female; Humans; Methamphetamine; N-Methyl-3,4-m | 2012 |
Consultation with the specialist: the central serotonin syndrome: paradigm for psychotherapeutic misadventure.
Topics: Adolescent; Amphetamine-Related Disorders; Antidepressive Agents; Antitussive Agents; Anxiety Disord | 2002 |
Death following ingestion of MDMA (ecstasy) and moclobemide.
Topics: Adolescent; Adult; Drug Interactions; Drug Overdose; Fatal Outcome; Female; Hallucinogens; Humans; M | 2003 |
Serotonin syndrome resulting from an herbal detox cocktail.
Topics: Adult; Antidepressive Agents, Second-Generation; Humans; Hypericum; Male; N-Methyl-3,4-methylenediox | 2004 |
Taking Ecstasy... it's child's play!
Topics: Anticonvulsants; Critical Illness; Exanthema; Female; Hallucinogens; Hemodynamics; Humans; Hyponatre | 2005 |
Serotonin (1A) receptor involvement in acute 3,4-methylenedioxymethamphetamine (MDMA) facilitation of social interaction in the rat.
Topics: Animals; Hallucinogens; Indoles; Interpersonal Relations; Ketanserin; Male; N-Methyl-3,4-methylenedi | 2005 |
Binge ethanol administration enhances the MDMA-induced long-term 5-HT neurotoxicity in rat brain.
Topics: Acetaldehyde; Alcoholic Intoxication; Aldehyde Dehydrogenase; Animals; Body Temperature; Brain; Cent | 2007 |
A possible perianesthetic serotonin syndrome related to intrathecal fentanyl.
Topics: Adult; Analgesics, Opioid; Ephedrine; Ergot Alkaloids; Fentanyl; Humans; Injections, Spinal; Male; M | 2008 |
A neurotoxic regimen of MDMA suppresses behavioral, thermal and neurochemical responses to subsequent MDMA administration.
Topics: Animals; Behavior, Animal; Body Temperature; Brain Chemistry; Dopamine; Dose-Response Relationship, | 1999 |