n-methyl-3,4-methylenedioxyamphetamine has been researched along with Neuroleptic Malignant Syndrome in 7 studies
N-Methyl-3,4-methylenedioxyamphetamine: An N-substituted amphetamine analog. It is a widely abused drug classified as a hallucinogen and causes marked, long-lasting changes in brain serotonergic systems. It is commonly referred to as MDMA or ecstasy.
3,4-methylenedioxymethamphetamine : A member of the class of benzodioxoles that is 1,3-benzodioxole substituted by a 2-(methylamino)propyl group at position 5.
Neuroleptic Malignant Syndrome: A potentially fatal syndrome associated primarily with the use of neuroleptic agents (see ANTIPSYCHOTIC AGENTS) which are in turn associated with dopaminergic receptor blockade (see RECEPTORS, DOPAMINE) in the BASAL GANGLIA and HYPOTHALAMUS, and sympathetic dysregulation. Clinical features include diffuse MUSCLE RIGIDITY; TREMOR; high FEVER; diaphoresis; labile blood pressure; cognitive dysfunction; and autonomic disturbances. Serum CPK level elevation and a leukocytosis may also be present. (From Adams et al., Principles of Neurology, 6th ed, p1199; Psychiatr Serv 1998 Sep;49(9):1163-72)
| Excerpt | Relevance | Reference |
|---|---|---|
| " The first case was due to a deadly intoxication by ecstasy and the second one to the deadly association of methadone and a possible neuroleptic malignant syndrome." | 4.98 | Postmortem Hyperthermia: Two Case Reports and a Review of the Literature. ( Franchi, A; Gambier, N; Gauchotte, G; Martrille, L; Raul, JS, 2018) |
| " Following initial improvement, she developed delayed rhabdomyolysis then haloperidol-induced neuroleptic malignant syndrome, which was treated with a total of 50 mg." | 3.78 | Ecstacy-induced delayed rhabdomyolysis and neuroleptic malignant syndrome in a patient with a novel variant in the ryanodine receptor type 1 gene. ( Hawryluck, LA; Kraeva, N; Riazi, S; Russell, T; Steel, AC, 2012) |
| "Dantrolene is a skeletal muscle relaxant that depresses the excitation-contraction coupling,however, the specificity of action remains unknown." | 2.42 | [Dantrolene. Pharmacological and therapeutic aspects]. ( Agarwal, K; Fiege, M; Gerbershagen, MU; Krause, T; Wappler, F, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (42.86) | 18.2507 |
| 2000's | 2 (28.57) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Franchi, A | 1 |
| Gauchotte, G | 1 |
| Gambier, N | 1 |
| Raul, JS | 1 |
| Martrille, L | 1 |
| Russell, T | 1 |
| Riazi, S | 1 |
| Kraeva, N | 1 |
| Steel, AC | 1 |
| Hawryluck, LA | 1 |
| Gerbershagen, MU | 1 |
| Fiege, M | 1 |
| Krause, T | 1 |
| Agarwal, K | 1 |
| Wappler, F | 1 |
| Kuwahara, T | 1 |
| Nakakura, T | 1 |
| Oda, S | 1 |
| Mori, M | 1 |
| Uehira, T | 1 |
| Okamoto, G | 1 |
| Yoshino, M | 1 |
| Sasakawa, A | 1 |
| Yajima, K | 1 |
| Umemoto, A | 1 |
| Takada, K | 1 |
| Makie, T | 1 |
| Yamamoto, Y | 1 |
| Nimmo, SM | 1 |
| Kennedy, BW | 1 |
| Tullett, WM | 1 |
| Blyth, AS | 1 |
| Dougall, JR | 1 |
| Demirkiran, M | 1 |
| Jankovic, J | 1 |
| Dean, JM | 1 |
| Naito, Y | 1 |
4 reviews available for n-methyl-3,4-methylenedioxyamphetamine and Neuroleptic Malignant Syndrome
| Article | Year |
|---|---|
Postmortem Hyperthermia: Two Case Reports and a Review of the Literature.
Topics: Adult; Drug Overdose; Female; Fever; Humans; Male; Methadone; N-Methyl-3,4-methylenedioxyamphetamine | 2018 |
[Dantrolene. Pharmacological and therapeutic aspects].
Topics: Dantrolene; Drug Interactions; Hallucinogens; Humans; Malignant Hyperthermia; Muscle Relaxants, Cent | 2003 |
Ecstasy intoxication: an overlap between serotonin syndrome and neuroleptic malignant syndrome.
Topics: Adolescent; Adult; Female; Hallucinogens; Humans; Infant; Male; N-Methyl-3,4-methylenedioxyamphetami | 1996 |
[Neuroleptic malignant syndrome-dopamine-serotonin syndrome--the physiopathology, diagnosis, and therapy].
Topics: Animals; Appetite Depressants; Dantrolene; Dopamine D2 Receptor Antagonists; Fenfluramine; Humans; M | 1997 |
3 other studies available for n-methyl-3,4-methylenedioxyamphetamine and Neuroleptic Malignant Syndrome
| Article | Year |
|---|---|
Ecstacy-induced delayed rhabdomyolysis and neuroleptic malignant syndrome in a patient with a novel variant in the ryanodine receptor type 1 gene.
Topics: Anesthetics, Inhalation; Antipsychotic Agents; Body Temperature; Caffeine; Central Nervous System St | 2012 |
Problems in three Japanese drug users with Human Immunodeficiency Virus infection.
Topics: 5-Methoxytryptamine; Adult; Amyl Nitrite; Antiretroviral Therapy, Highly Active; Asian People; Drug | 2008 |
Drug-induced hyperthermia.
Topics: 3,4-Methylenedioxyamphetamine; Adult; Designer Drugs; Female; Fluoxetine; Humans; Male; Middle Aged; | 1993 |