n-methyl-3,4-methylenedioxyamphetamine has been researched along with Nerve Degeneration in 31 studies
N-Methyl-3,4-methylenedioxyamphetamine: An N-substituted amphetamine analog. It is a widely abused drug classified as a hallucinogen and causes marked, long-lasting changes in brain serotonergic systems. It is commonly referred to as MDMA or ecstasy.
3,4-methylenedioxymethamphetamine : A member of the class of benzodioxoles that is 1,3-benzodioxole substituted by a 2-(methylamino)propyl group at position 5.
Nerve Degeneration: Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.
| Excerpt | Relevance | Reference |
|---|---|---|
| " While it is known that their abuse could result in adverse health complications, including neurotoxicity, both the environmental conditions and activity states associated with their intake could strongly enhance drug toxicity, often resulting in life-threatening health complications." | 2.48 | Environmental conditions modulate neurotoxic effects of psychomotor stimulant drugs of abuse. ( Kiyatkin, EA; Sharma, HS, 2012) |
| " Little is known about toxic effects of MDMA and potential underlying molecular mechanisms in the developing brain." | 1.36 | Neurotoxic effects of MDMA (ecstasy) on the developing rodent brain. ( Bendix, I; Brait, D; Dzietko, M; Endesfelder, S; Felderhoff-Mueser, U; Hansen, HH; Klaus, J; Sifringer, M, 2010) |
| "Pretreatment with fluoxetine (10 mg kg(-1), x2) failed to alter cerebral MDMA accumulation compared to saline pretreated controls." | 1.31 | The mechanisms involved in the long-lasting neuroprotective effect of fluoxetine against MDMA ('ecstasy')-induced degeneration of 5-HT nerve endings in rat brain. ( Camarero, J; Colado, MI; Esteban, B; Green, AR; Peter, MJ; Sanchez, V, 2001) |
| "Pretreatment with chlormethiazole (100 mg/kg i." | 1.29 | Chlormethiazole, dizocilpine and haloperidol prevent the degeneration of serotonergic nerve terminals induced by administration of MDMA ('Ecstasy') to rats. ( Green, AR; Hewitt, KE, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (12.90) | 18.7374 |
| 1990's | 12 (38.71) | 18.2507 |
| 2000's | 9 (29.03) | 29.6817 |
| 2010's | 5 (16.13) | 24.3611 |
| 2020's | 1 (3.23) | 2.80 |
| Authors | Studies |
|---|---|
| Costa, G | 2 |
| Spulber, S | 1 |
| Paci, E | 1 |
| Casu, MA | 1 |
| Ceccatelli, S | 1 |
| Simola, N | 1 |
| Morelli, M | 2 |
| Frau, L | 1 |
| Porceddu, PF | 1 |
| Khairnar, A | 1 |
| Castelli, MP | 1 |
| Ennas, MG | 1 |
| Madeddu, C | 1 |
| Wardas, J | 1 |
| Li, IH | 1 |
| Ma, KH | 1 |
| Kao, TJ | 1 |
| Lin, YY | 1 |
| Weng, SJ | 1 |
| Yen, TY | 1 |
| Chen, LC | 1 |
| Huang, YS | 1 |
| Capela, JP | 1 |
| Lautenschlager, M | 1 |
| Dirnagl, U | 1 |
| Bastos, ML | 1 |
| Carvalho, F | 1 |
| Meisel, A | 1 |
| Dzietko, M | 1 |
| Sifringer, M | 1 |
| Klaus, J | 1 |
| Endesfelder, S | 1 |
| Brait, D | 1 |
| Hansen, HH | 1 |
| Bendix, I | 1 |
| Felderhoff-Mueser, U | 1 |
| Kiyatkin, EA | 1 |
| Sharma, HS | 1 |
| Jeng, W | 1 |
| Wells, PG | 1 |
| Ricaurte, GA | 3 |
| Yuan, J | 2 |
| Hatzidimitriou, G | 1 |
| Cord, BJ | 2 |
| McCann, UD | 3 |
| Callahan, BT | 1 |
| Heilig, M | 1 |
| Schmued, LC | 1 |
| Wang, X | 1 |
| Baumann, MH | 1 |
| Dersch, CM | 1 |
| Rothman, RB | 1 |
| Hewitt, KE | 1 |
| Green, AR | 9 |
| Kramer, HK | 1 |
| Poblete, JC | 1 |
| Azmitia, EC | 1 |
| Colado, MI | 7 |
| Goodwin, GM | 1 |
| O'Shea, E | 4 |
| Granados, R | 4 |
| Murray, TK | 1 |
| Huether, G | 1 |
| Zhou, D | 1 |
| Rüther, E | 1 |
| Zheng, Y | 1 |
| Laverty, R | 1 |
| Esteban, B | 5 |
| Vollenweider, FX | 1 |
| Gamma, A | 1 |
| Liechti, M | 1 |
| Huber, T | 1 |
| Sanchez, V | 2 |
| Camarero, J | 2 |
| Peter, MJ | 1 |
| Mechan, AO | 1 |
| Elliott, JM | 1 |
| Schmidt, CJ | 1 |
| Black, CK | 1 |
| Taylor, VL | 1 |
| Battaglia, G | 2 |
| Yeh, SY | 1 |
| De Souza, EB | 2 |
| O'Hearn, E | 1 |
| Kuhar, MJ | 1 |
| Molliver, ME | 1 |
| Gibb, JW | 1 |
| Johnson, M | 1 |
| Hanson, GR | 1 |
| Scallet, AC | 1 |
| Lipe, GW | 1 |
| Ali, SF | 1 |
| Holson, RR | 1 |
| Frith, CH | 1 |
| Slikker, W | 1 |
2 reviews available for n-methyl-3,4-methylenedioxyamphetamine and Nerve Degeneration
| Article | Year |
|---|---|
Environmental conditions modulate neurotoxic effects of psychomotor stimulant drugs of abuse.
Topics: Animals; Blood-Brain Barrier; Body Temperature; Brain; Brain Edema; Environment; Fever; Hot Temperat | 2012 |
Causes and consequences of the loss of serotonergic presynapses elicited by the consumption of 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") and its congeners.
Topics: Amphetamine-Related Disorders; Animals; Energy Metabolism; Hallucinogens; Humans; N-Methyl-3,4-methy | 1997 |
29 other studies available for n-methyl-3,4-methylenedioxyamphetamine and Nerve Degeneration
| Article | Year |
|---|---|
In utero exposure to dexamethasone causes a persistent and age-dependent exacerbation of the neurotoxic effects and glia activation induced by MDMA in dopaminergic brain regions of C57BL/6J mice.
Topics: Age Factors; Animals; Brain; Calcium-Binding Proteins; Dexamethasone; Disease Models, Animal; Diseas | 2021 |
Influence of caffeine on 3,4-methylenedioxymethamphetamine-induced dopaminergic neuron degeneration and neuroinflammation is age-dependent.
Topics: Age Factors; Aging; Animals; Caffeine; Dopaminergic Neurons; Drug Synergism; Inflammation; Male; Mic | 2016 |
Involvement of autophagy upregulation in 3,4-methylenedioxymethamphetamine ('ecstasy')-induced serotonergic neurotoxicity.
Topics: Adenine; Animals; Autophagy; Benzylamines; Brain Stem; Cells, Cultured; Citalopram; Dose-Response Re | 2016 |
5,7-Dihydroxitryptamine toxicity to serotonergic neurons in serum free raphe cultures.
Topics: 5,7-Dihydroxytryptamine; Animals; Cells, Cultured; Culture Media, Serum-Free; Dose-Response Relation | 2008 |
Neurotoxic effects of MDMA (ecstasy) on the developing rodent brain.
Topics: Adolescent; Animals; Animals, Newborn; Brain; Brain-Derived Neurotrophic Factor; Female; Humans; Mal | 2010 |
Reduced 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy)-initiated oxidative DNA damage and neurodegeneration in prostaglandin H synthase-1 knockout mice.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Behavior, Animal; Blotting, Western; Brain Chemistry; Cyclooxy | 2010 |
RETRACTED: Severe dopaminergic neurotoxicity in primates after a common recreational dose regimen of MDMA ("ecstasy").
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Autoradiography; Axons; Brain; Carrier Proteins; Corpus Str | 2002 |
Effect of glucoprivation on serotonin neurotoxicity induced by substituted amphetamines.
Topics: Amphetamines; Animals; Antimetabolites; Biogenic Monoamines; Body Temperature; Carrier Proteins; Deo | 2002 |
[Ecstasy is a dangerous drug the society chooses to ignore].
Topics: Animals; Brain; Hallucinogens; Humans; N-Methyl-3,4-methylenedioxyamphetamine; Nerve Degeneration; N | 2003 |
Demonstration and localization of neuronal degeneration in the rat forebrain following a single exposure to MDMA.
Topics: Animals; Cell Count; Fluorescent Dyes; Hallucinogens; Male; N-Methyl-3,4-methylenedioxyamphetamine; | 2003 |
Restoration of 3,4-methylenedioxymethamphetamine-induced 5-HT depletion by the administration of L-5-hydroxytryptophan.
Topics: 5-Hydroxytryptophan; Animals; Antidepressive Agents, Second-Generation; Binding, Competitive; Brain; | 2007 |
Chlormethiazole, dizocilpine and haloperidol prevent the degeneration of serotonergic nerve terminals induced by administration of MDMA ('Ecstasy') to rats.
Topics: Animals; Chlormethiazole; Dizocilpine Maleate; Haloperidol; Hydroxyindoleacetic Acid; Male; N-Methyl | 1994 |
3,4-Methylenedioxymethamphetamine ('Ecstasy') promotes the translocation of protein kinase C (PKC): requirement of viable serotonin nerve terminals.
Topics: Animals; Binding Sites; Biological Transport; Cerebral Cortex; Male; N-Methyl-3,4-methylenedioxyamph | 1995 |
The spin trap reagent alpha-phenyl-N-tert-butyl nitrone prevents 'ecstasy'-induced neurodegeneration of 5-hydroxytryptamine neurones.
Topics: Analysis of Variance; Animals; Binding, Competitive; Cerebral Cortex; Cyclic N-Oxides; Free Radicals | 1995 |
Ecstasy and neurodegeneration.
Topics: Brain Diseases; Chronic Disease; Hallucinogens; Humans; N-Methyl-3,4-methylenedioxyamphetamine; Nerv | 1996 |
In vivo evidence for free radical involvement in the degeneration of rat brain 5-HT following administration of MDMA ('ecstasy') and p-chloroamphetamine but not the degeneration following fenfluramine.
Topics: Animals; Biogenic Monoamines; Body Temperature; Brain Chemistry; Fenfluramine; Free Radical Scavenge | 1997 |
Role of brain nitric oxide in (+/-)3,4-methylenedioxymethamphetamine (MDMA)-induced neurotoxicity in rats.
Topics: Animals; Body Temperature; Enzyme Activation; Enzyme Inhibitors; Hydroxyindoleacetic Acid; Indazoles | 1998 |
Role of hyperthermia in the protective action of clomethiazole against MDMA ('ecstasy')-induced neurodegeneration, comparison with the novel NMDA channel blocker AR-R15896AR.
Topics: Animals; Body Temperature; Brain Chemistry; Chlormethiazole; Excitatory Amino Acid Antagonists; Feve | 1998 |
The relationship between the degree of neurodegeneration of rat brain 5-HT nerve terminals and the dose and frequency of administration of MDMA ('ecstasy').
Topics: Animals; Body Temperature; Brain; Cerebral Cortex; Corpus Striatum; Dose-Response Relationship, Drug | 1998 |
In vivo evidence against clomethiazole being neuroprotective against MDMA ('ecstasy')-induced degeneration of rat brain 5-HT nerve terminals by a free radical scavenging mechanism.
Topics: Animals; Biotransformation; Body Temperature; Brain; Cerebral Cortex; Chlormethiazole; Corpus Striat | 1999 |
Is a single dose of MDMA harmless?
Topics: Animals; Clinical Trials as Topic; Ethics, Medical; Hallucinogens; Humans; Hydroxyindoleacetic Acid; | 1999 |
Caveat emptor: editors beware.
Topics: Animals; Brain; Clinical Trials as Topic; Hallucinogens; Humans; N-Methyl-3,4-methylenedioxyamphetam | 2001 |
The mechanisms involved in the long-lasting neuroprotective effect of fluoxetine against MDMA ('ecstasy')-induced degeneration of 5-HT nerve endings in rat brain.
Topics: Animals; Binding, Competitive; Body Temperature; Brain; Cerebral Cortex; Fluoxetine; Fluvoxamine; In | 2001 |
A study of the mechanisms involved in the neurotoxic action of 3,4-methylenedioxymethamphetamine (MDMA, 'ecstasy') on dopamine neurones in mouse brain.
Topics: Animals; Chlormethiazole; Corpus Striatum; Cyclic N-Oxides; Dizocilpine Maleate; Dopamine; Dose-Resp | 2001 |
L-DOPA potentiation of the serotonergic deficits due to a single administration of 3,4-methylenedioxymethamphetamine, p-chloroamphetamine or methamphetamine to rats.
Topics: 3,4-Methylenedioxyamphetamine; Animals; Brain Chemistry; Cerebral Cortex; Corpus Striatum; Dopamine; | 1991 |
MDMA-induced neurotoxicity: parameters of degeneration and recovery of brain serotonin neurons.
Topics: 3,4-Methylenedioxyamphetamine; Amphetamines; Animals; Biological Transport, Active; Brain; Dose-Resp | 1988 |
Methylenedioxyamphetamine (MDA) and methylenedioxymethamphetamine (MDMA) cause selective ablation of serotonergic axon terminals in forebrain: immunocytochemical evidence for neurotoxicity.
Topics: 3,4-Methylenedioxyamphetamine; Amphetamines; Animals; Axons; Catecholamines; Cell Survival; Dienceph | 1988 |
MK-801 attenuates the methamphetamine induced decreased in tryptophan hydroxylase activity.
Topics: 3,4-Methylenedioxyamphetamine; Animals; Anticonvulsants; Brain; Corpus Striatum; Dibenzocycloheptene | 1989 |
Neuropathological evaluation by combined immunohistochemistry and degeneration-specific methods: application to methylenedioxymethamphetamine.
Topics: 3,4-Methylenedioxyamphetamine; Amphetamines; Animals; Axons; Caudate Nucleus; Immunohistochemistry; | 1988 |