n-methyl-3,4-methylenedioxyamphetamine has been researched along with Hypothermia in 20 studies
N-Methyl-3,4-methylenedioxyamphetamine: An N-substituted amphetamine analog. It is a widely abused drug classified as a hallucinogen and causes marked, long-lasting changes in brain serotonergic systems. It is commonly referred to as MDMA or ecstasy.
3,4-methylenedioxymethamphetamine : A member of the class of benzodioxoles that is 1,3-benzodioxole substituted by a 2-(methylamino)propyl group at position 5.
Hypothermia: Lower than normal body temperature, especially in warm-blooded animals.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In conclusion, the study suggests a potentially dangerous effect of concomitant caffeine and mephedrone, and highlights the importance of taking polydrug use into consideration when investigating the acute adverse effect profile of popular recreational drugs." | 1.43 | Caffeine alters the behavioural and body temperature responses to mephedrone without causing long-term neurotoxicity in rats. ( Fone, KC; Green, AR; King, MV; Shortall, SE, 2016) |
| " GHB is frequently combined with other recreational drugs although these interactions are not well characterised." | 1.35 | Sedative and hypothermic effects of gamma-hydroxybutyrate (GHB) in rats alone and in combination with other drugs: assessment using biotelemetry. ( McGregor, IS; van Nieuwenhuijzen, PS, 2009) |
| " Binge dosing produces a higher final peak response than a similar non-divided dose." | 1.32 | Effect of ambient temperature and a prior neurotoxic dose of 3,4-methylenedioxymethamphetamine (MDMA) on the hyperthermic response of rats to a single or repeated ('binge' ingestion) low dose of MDMA. ( Colado, MI; Elliott, JM; Green, AR; O'Shea, E; Saadat, KS; Sanchez, V, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (10.00) | 18.2507 |
| 2000's | 11 (55.00) | 29.6817 |
| 2010's | 5 (25.00) | 24.3611 |
| 2020's | 2 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mootz, JRK | 1 |
| Miner, NB | 1 |
| Phillips, TJ | 1 |
| Muskiewicz, DE | 1 |
| Resendiz-Gutierrez, F | 1 |
| Issa, O | 1 |
| Hall, FS | 1 |
| Shortall, SE | 2 |
| Green, AR | 6 |
| Fone, KC | 3 |
| King, MV | 2 |
| Rusyniak, DE | 1 |
| Ootsuka, Y | 1 |
| Blessing, WW | 1 |
| van Nieuwenhuijzen, PS | 1 |
| McGregor, IS | 1 |
| Izco, M | 1 |
| Gutierrez-Lopez, MD | 1 |
| Marchant, I | 1 |
| O'Shea, E | 4 |
| Colado, MI | 4 |
| Docherty, JR | 1 |
| Milroy, CM | 1 |
| Swift, KM | 1 |
| Bull, EJ | 1 |
| Hutson, PH | 1 |
| Sanchez, V | 1 |
| Saadat, KS | 2 |
| Elliott, JM | 2 |
| Johnson, EA | 1 |
| O'Callaghan, JP | 1 |
| Miller, DB | 1 |
| Jones, DC | 1 |
| Duvauchelle, C | 1 |
| Ikegami, A | 1 |
| Olsen, CM | 1 |
| Lau, SS | 1 |
| de la Torre, R | 1 |
| Monks, TJ | 1 |
| Aguirre, N | 3 |
| Ballaz, S | 1 |
| Lasheras, B | 3 |
| Del Río, J | 2 |
| Barrionuevo, M | 1 |
| Ramírez, MJ | 1 |
| Hervías, I | 1 |
| Daws, LC | 1 |
| Irvine, RJ | 1 |
| Callaghan, PD | 1 |
| Toop, NP | 1 |
| White, JM | 1 |
| Bochner, F | 1 |
| Yuan, J | 1 |
| Cord, BJ | 1 |
| McCann, UD | 1 |
| Callahan, BT | 1 |
| Ricaurte, GA | 1 |
2 reviews available for n-methyl-3,4-methylenedioxyamphetamine and Hypothermia
| Article | Year |
|---|---|
The role of monoamines in the changes in body temperature induced by 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) and its derivatives.
Topics: Animals; Biogenic Monoamines; Body Temperature; Dose-Response Relationship, Drug; Fever; Humans; Hyp | 2010 |
A review of the mechanisms involved in the acute MDMA (ecstasy)-induced hyperthermic response.
Topics: Animals; Body Temperature; Cytokines; Dose-Response Relationship, Drug; Hallucinogens; Humans; Hypot | 2004 |
18 other studies available for n-methyl-3,4-methylenedioxyamphetamine and Hypothermia
| Article | Year |
|---|---|
Differential genetic risk for methamphetamine intake confers differential sensitivity to the temperature-altering effects of other addictive drugs.
Topics: Amphetamine-Related Disorders; Analgesics, Opioid; Animals; Cocaine; Dopamine Agents; Female; Genoty | 2020 |
Synthetic psychoactive cathinones: hypothermia and reduced lethality compared to methamphetamine and methylenedioxymethamphetamine.
Topics: Alkaloids; Animals; Behavior, Animal; Body Temperature Regulation; Central Nervous System Stimulants | 2020 |
Caffeine alters the behavioural and body temperature responses to mephedrone without causing long-term neurotoxicity in rats.
Topics: Animals; Behavior, Animal; Body Temperature; Brain; Caffeine; Discrimination, Psychological; Dopamin | 2016 |
When administered to rats in a cold environment, 3,4-methylenedioxymethamphetamine reduces brown adipose tissue thermogenesis and increases tail blood flow: effects of pretreatment with 5-HT1A and dopamine D2 antagonists.
Topics: Adipose Tissue, Brown; Animals; Cold Temperature; Dopamine Antagonists; Dopamine D2 Receptor Antagon | 2008 |
Sedative and hypothermic effects of gamma-hydroxybutyrate (GHB) in rats alone and in combination with other drugs: assessment using biotelemetry.
Topics: Animals; Baclofen; Benzazepines; Dose-Response Relationship, Drug; Drug Interactions; Drug Tolerance | 2009 |
Administration of neurotoxic doses of MDMA reduces sensitivity to ethanol and increases GAT-1 immunoreactivity in mice striatum.
Topics: Alcohol Drinking; Animals; Corpus Striatum; Dopamine; Drug Tolerance; Ethanol; GABA Plasma Membrane | 2010 |
"Ecstasy" associated deaths: what is a fatal concentration ? Analysis of a case series.
Topics: Accidental Falls; Accidents, Traffic; Central Nervous System Depressants; Drowning; Ethanol; Forensi | 2011 |
Differential effects of cathinone compounds and MDMA on body temperature in the rat, and pharmacological characterization of mephedrone-induced hypothermia.
Topics: Adrenergic Antagonists; Alkaloids; Animals; Body Temperature; Body Temperature Regulation; Brain; Ca | 2013 |
Reduced social interaction following 3,4-methylenedioxymethamphetamine is not associated with enhanced 5-HT 2C receptor responsivity.
Topics: Animals; Brain; Corticosterone; Exploratory Behavior; Hydroxyindoleacetic Acid; Hypothermia; In Vitr | 2003 |
Effect of ambient temperature and a prior neurotoxic dose of 3,4-methylenedioxymethamphetamine (MDMA) on the hyperthermic response of rats to a single or repeated ('binge' ingestion) low dose of MDMA.
Topics: Animals; Body Temperature; Dose-Response Relationship, Drug; Heating; Hypothermia; Male; N-Methyl-3, | 2004 |
Brain concentrations of d-MDMA are increased after stress.
Topics: Animals; Body Temperature; Cold Temperature; Corpus Striatum; Dopamine; Female; Hypothermia; Mice; M | 2004 |
Serotonergic neurotoxic metabolites of ecstasy identified in rat brain.
Topics: Acetylcysteine; Animals; Biotransformation; Brain; Calibration; Chromatography, High Pressure Liquid | 2005 |
Studies on the effect of MDMA ('ecstasy') on the body temperature of rats housed at different ambient room temperatures.
Topics: Animals; Body Temperature; Brain Chemistry; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; | 2005 |
MDMA ('Ecstasy') enhances 5-HT1A receptor density and 8-OH-DPAT-induced hypothermia: blockade by drugs preventing 5-hydroxytryptamine depletion.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Body Temperature; Hydroxyindoleacetic Acid; Hypotha | 1998 |
Alpha-lipoic acid prevents 3,4-methylenedioxy-methamphetamine (MDMA)-induced neurotoxicity.
Topics: Animals; Antioxidants; Astrocytes; Binding Sites; Carrier Proteins; Fever; Frontal Lobe; Glial Fibri | 1999 |
2-Deoxy-D-glucose prevents and nicotinamide potentiates 3, 4-methylenedioxymethamphetamine-induced serotonin neurotoxicity.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adenosine Triphosphate; Animals; Body Temperature; Brain; Carrier Pr | 2000 |
Differential behavioural and neurochemical effects of para-methoxyamphetamine and 3,4-methylenedioxymethamphetamine in the rat.
Topics: Amphetamines; Animals; Behavior, Animal; Body Temperature; Hallucinogens; Hypothermia; Motor Activit | 2000 |
Effect of depleting vesicular and cytoplasmic dopamine on methylenedioxymethamphetamine neurotoxicity.
Topics: Adrenergic Uptake Inhibitors; alpha-Methyltyrosine; Animals; Corpus Striatum; Cytoplasm; Cytoplasmic | 2002 |