Page last updated: 2024-10-21

n-methyl-3,4-methylenedioxyamphetamine and Fever

n-methyl-3,4-methylenedioxyamphetamine has been researched along with Fever in 171 studies

N-Methyl-3,4-methylenedioxyamphetamine: An N-substituted amphetamine analog. It is a widely abused drug classified as a hallucinogen and causes marked, long-lasting changes in brain serotonergic systems. It is commonly referred to as MDMA or ecstasy.
3,4-methylenedioxymethamphetamine : A member of the class of benzodioxoles that is 1,3-benzodioxole substituted by a 2-(methylamino)propyl group at position 5.

Fever: An abnormal elevation of body temperature, usually as a result of a pathologic process.

Research Excerpts

ExcerptRelevanceReference
"The use of dantrolene in the treatment of hyperpyrexia related to MDMA (3,4-methylenedioxymethamphetamine) is controversial, with little data available to guide clinical decision-making."8.86Dantrolene in the treatment of MDMA-related hyperpyrexia: a systematic review. ( Brubacher, JR; Grunau, BE; Wiens, MO, 2010)
"We describe two cases of hyperthermia and rhabdomyolysis related to cocaine and/or ecstasy consumption."8.81[Rhabdomyolysis syndrome and hyperthermia secondary to cocaine and/or ecstasy consumption. Report of 2 new cases and review of the problem]. ( Arribas Castrillo, JM; García Diez, A; Suárez Arias, R; Vallina Alvarez, E, 2002)
" The first case was due to a deadly intoxication by ecstasy and the second one to the deadly association of methadone and a possible neuroleptic malignant syndrome."4.98Postmortem Hyperthermia: Two Case Reports and a Review of the Literature. ( Franchi, A; Gambier, N; Gauchotte, G; Martrille, L; Raul, JS, 2018)
"The use of dantrolene in the treatment of hyperpyrexia related to MDMA (3,4-methylenedioxymethamphetamine) is controversial, with little data available to guide clinical decision-making."4.86Dantrolene in the treatment of MDMA-related hyperpyrexia: a systematic review. ( Brubacher, JR; Grunau, BE; Wiens, MO, 2010)
"We describe two cases of hyperthermia and rhabdomyolysis related to cocaine and/or ecstasy consumption."4.81[Rhabdomyolysis syndrome and hyperthermia secondary to cocaine and/or ecstasy consumption. Report of 2 new cases and review of the problem]. ( Arribas Castrillo, JM; García Diez, A; Suárez Arias, R; Vallina Alvarez, E, 2002)
"Patients almost invariably present with convulsions accompanied by sympathetic signs and symptoms such as hyperthermia."2.49Ecstasy intoxication as an unusual cause of epileptic seizures in young children. ( Desmet, K; Eerdekens, K; Lemmens, F; Pauwels, S; Penders, J; Poesen, K; Vermeersch, P, 2013)
" While it is known that their abuse could result in adverse health complications, including neurotoxicity, both the environmental conditions and activity states associated with their intake could strongly enhance drug toxicity, often resulting in life-threatening health complications."2.48Environmental conditions modulate neurotoxic effects of psychomotor stimulant drugs of abuse. ( Kiyatkin, EA; Sharma, HS, 2012)
" Their abuse is associated with severe neurologic and psychiatric adverse events including the development of psychotic states."2.44Neurotoxicity of substituted amphetamines: molecular and cellular mechanisms. ( Cadet, JL; Jayanthi, S; Krasnova, IN; Lyles, J, 2007)
" Clinically important toxic effects have been reported, including fatalities."2.43Acute toxic effects of 'Ecstasy' (MDMA) and related compounds: overview of pathophysiology and clinical management. ( Hall, AP; Henry, JA, 2006)
"Adverse effects include hyperthermia, seizures, cardiac arrhythmias, hepatotoxicity, hyponatraemia and many psychiatric disorders."2.41Agony and ecstasy: a review of MDMA effects and toxicity. ( Burgess, C; Gill, M; O'Donohoe, A, 2000)
"Clinically, the case highlights how physicians should be aware of the unusual time course adverse effects of ecstasy can have."1.56Protracted hyperthermia and delayed rhabdomyolysis in ecstasy toxicity: A case report. ( Eum, KS; Ghaffari-Rafi, A; Jahanmir, J; Villanueva, J, 2020)
" Current studies focused on the effects of co- and/or postinhibition of VMAT2 on the acute and chronic effects of MDMA and on the dose-response relationship between MDMA-induced elevations in body temperature and subsequent reductions in indolamine concentrations."1.51Concurrent Inhibition of Vesicular Monoamine Transporter 2 Does Not Protect Against 3,4-Methylenedioxymethamphetamine (Ecstasy) Induced Neurotoxicity. ( Cholanians, AB; Lau, SS; Monks, TJ; Phan, AV, 2019)
"Hyperpyrexia is a well-documented adverse effect of 3,4-methylenedioxymethamphetamine (MDMA) and is associated with a poor prognosis."1.48Too Hot to Handle: A Case Report of Extreme Pyrexia After MDMA Ingestion. ( Auzinger, G; Jahns, FP; Pineau Mitchell, A, 2018)
" The present study aimed to evaluate the differential toxic effects of MDMA in adolescent and aged Wistar rats, using doses pharmacologically comparable to humans."1.48Aged rats are more vulnerable than adolescents to "ecstasy"-induced toxicity. ( Barbosa, DJ; Bastos, ML; Capela, JP; Carvalho, F; Costa, VM; Duarte, JA; Duarte-Araújo, M; Feio-Azevedo, R; Fernandes, E; Gomes, S; Marques, F; Pereira, FC; Pita, I; Teixeira-Gomes, A, 2018)
"Carvedilol was modestly effective in attenuating MDMA-induced hyperthermia by moderately inhibiting skin vasoconstriction, and labetalol was ineffective."1.43Clinically Relevant Pharmacological Strategies That Reverse MDMA-Induced Brain Hyperthermia Potentiated by Social Interaction. ( Baumann, MH; Kiyatkin, EA; Ren, S; Shaham, Y; Wakabayashi, KT, 2016)
" In conclusion, the study suggests a potentially dangerous effect of concomitant caffeine and mephedrone, and highlights the importance of taking polydrug use into consideration when investigating the acute adverse effect profile of popular recreational drugs."1.43Caffeine alters the behavioural and body temperature responses to mephedrone without causing long-term neurotoxicity in rats. ( Fone, KC; Green, AR; King, MV; Shortall, SE, 2016)
" We showed that MDMA metabolites exhibited toxicity to SH-SY5Y differentiated cells, being the GSH and NAC conjugates more toxic than their catecholic precursors and MDMA."1.40"Ecstasy"-induced toxicity in SH-SY5Y differentiated cells: role of hyperthermia and metabolites. ( Barbosa, DJ; Bastos, ML; Branco, PS; Capela, JP; Carvalho, F; Fernandes, E; Ferreira, LM; Silva, R, 2014)
"After achieving predefined malignant hyperthermia criteria, standardised therapy was initiated; dantrolene sodium suspension (5 mg kg(-1)) was administered and the injection was repeated after 24 min."1.393,4-Methylenedioxymethamphetamine induces a hyperthermic and hypermetabolic crisis in pigs with and without a genetic disposition for malignant hyperthermia. ( Becker, S; Gerbershagen, MU; Oldewurtel, C; Richard, A; Schäfer, U; Schütte, JK; Singler, P; Starosse, A; Wappler, F, 2013)
"Mirtazapine is a novel antidepressant and a potent 5-HT(2A) receptor antagonist."1.37The effects of mirtazapine and fluoxetine on hyperthermia induced by 3,4-methylenedioxymethamphetamine (MDMA) in rats. ( Iwamura, T; Kasai, M; Kato, S; Nisijima, K; Shioda, K; Yoshino, T, 2011)
"Treatment with prazosin (1mg/kg, i."1.36Role of serotonin and/or norepinephrine in the MDMA-induced increase in extracellular glucose and glycogenolysis in the rat brain. ( Bhide, N; Gudelsky, GA; Pachmerhiwala, R; Straiko, M, 2010)
" Blood samples for analysis of glucose and lactate were taken at 30-45 min intervals before and after drug dosing and body temperature was monitored by telemetry."1.34Serotonin mediates rapid changes of striatal glucose and lactate metabolism after systemic 3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") administration in awake rats. ( Cumming, P; Gramsbergen, JB, 2007)
"The purpose of the current study was to establish dose-response relationships for the effects of a number of commonly used illicit stimulants and investigate the behavioral response to increased core temperature."1.34Pharmacological and behavioral determinants of cocaine, methamphetamine, 3,4-methylenedioxymethamphetamine, and para-methoxyamphetamine-induced hyperthermia. ( Irvine, RJ; Jaehne, EJ; Salem, A, 2007)
" These results extend our recent findings of additive toxic effects when METH is combined with MDMA."1.33MDMA ('Ecstasy') and methamphetamine combined: order of administration influences hyperthermic and long-term adverse effects in female rats. ( Clemens, KJ; Cornish, JL; Hunt, GE; Li, KM; McGregor, IS, 2005)
"He presented with fever and seizures, tachycardia, hypertension, and hyperthermia."1.33Accidental ingestion of Ecstasy in a toddler. ( Chang, YJ; Chao, HC; Kong, MS; Lai, MW, 2005)
" The acute effects stemming from this association, in tandem with the final potentiation of serotonergic terminals injury, provide evidence of the potentially greater long-term adverse effects of this particular recreational drug combination."1.33Association of caffeine to MDMA does not increase antinociception but potentiates adverse effects of this recreational drug. ( Camarasa, J; Escubedo, E; Pubill, D, 2006)
"These results indicate that hyperthermia at the time of dosing with MDMA is not necessary to produce subsequent 5-HT depletion and anxiety in rats."1.32Increased anxiety and "depressive" symptoms months after MDMA ("ecstasy") in rats: drug-induced hyperthermia does not predict long-term outcomes. ( Blokland, A; Clemens, KJ; Cornish, JL; Gurtman, CG; Hunt, GE; Li, KM; McGregor, IS; Morley, KC, 2003)
" "Poisoned ecstasy" was widely reported by the media as being responsible for the adverse effects observed."1.32Multiple toxicity from 3,4-methylenedioxymethamphetamine ("ecstasy"). ( Dargan, PI; Greene, SL; Jones, AL; Kerins, M; O'connor, N, 2003)
"Nantenine functions as an effective antagonist against a wide range of MDMA-induced effects in mice."1.32Nantenine: an antagonist of the behavioral and physiological effects of MDMA in mice. ( Chen, X; Fantegrossi, WE; Karabenick, RL; Kiessel, CL; Leach, PT; Ohizumi, Y; Rice, KC; Ullrich, T; Van Martin, C; Woods, JH, 2004)
"The consumption of 3,4-methylenedioxymethamphetamine (ecstasy; MDMA) may cause hepatocellular damage in humans, a toxic effect that has been increasing in frequency in the last few years, although the underlying mechanisms are still unknown."1.31Is hyperthermia the triggering factor for hepatotoxicity induced by 3,4-methylenedioxymethamphetamine (ecstasy)? An in vitro study using freshly isolated mouse hepatocytes. ( Bastos, ML; Carvalho, F; Carvalho, M, 2001)
" After repeated dosing (8 x 20 mg/kg, i."1.31Behavioural, hyperthermic and neurotoxic effects of 3,4-methylenedioxymethamphetamine analogues in the Wistar rat. ( Boland, G; Kelly, JP; O'Boyle, KM; O'Loinsigh, ED, 2001)
"He subsequently developed acute respiratory distress syndrome (ARDS), disseminated intravascular coagulopathy (DIC) and acute renal failure."1.30Fatal multi-organ failure after suicidal overdose with MDMA, 'ecstasy': case report and review of the literature. ( Seger, D; Walubo, A, 1999)
"[3H]-paroxetine binding was also decreased by 27% in the cortex, indicating that the amine loss reflected a neurodegenerative change."1.29The hyperthermic and neurotoxic effects of 'Ecstasy' (MDMA) and 3,4 methylenedioxyamphetamine (MDA) in the Dark Agouti (DA) rat, a model of the CYP2D6 poor metabolizer phenotype. ( Colado, MI; Green, AR; Williams, JL, 1995)
" At each Ta drinking water was freely available following dosing on one session and temporarily unavailable on a second."1.29Hyperthermia following MDMA administration in rats: effects of ambient temperature, water consumption, and chronic dosing. ( Dafters, RI, 1995)
"Four patients presented with acute liver failure without hyperthermia."1.29Acute liver damage and ecstasy ingestion. ( Ellis, AJ; Portmann, B; Wendon, JA; Williams, R, 1996)

Research

Studies (171)

TimeframeStudies, this research(%)All Research%
pre-19901 (0.58)18.7374
1990's31 (18.13)18.2507
2000's90 (52.63)29.6817
2010's46 (26.90)24.3611
2020's3 (1.75)2.80

Authors

AuthorsStudies
Stilmant, AC1
Zhu, L1
Gorur, Y1
Cardos, B1
Yerna, M1
Ali, D1
Lemoine, C1
Bréhin, C1
Micheau, P1
Lavit, M1
Claudet, I1
Ghaffari-Rafi, A1
Eum, KS1
Villanueva, J1
Jahanmir, J1
Haaland, A1
Warman, E1
Pushkar, I1
Likourezos, A1
Friedman, MS1
Jahns, FP1
Pineau Mitchell, A1
Auzinger, G1
Feio-Azevedo, R2
Costa, VM2
Barbosa, DJ2
Teixeira-Gomes, A2
Pita, I1
Gomes, S1
Pereira, FC1
Duarte-Araújo, M2
Duarte, JA5
Marques, F1
Fernandes, E7
Bastos, ML7
Carvalho, F10
Capela, JP4
Franchi, A1
Gauchotte, G1
Gambier, N1
Raul, JS1
Martrille, L1
Ridge, EA1
Pachhain, S1
Choudhury, SR1
Bodnar, SR1
Larsen, RA1
Phuntumart, V1
Sprague, JE12
Cholanians, AB2
Phan, AV2
Lau, SS2
Monks, TJ3
Musolino, ST1
Schartner, EP1
Hutchinson, MR1
Salem, A3
Pauwels, S1
Lemmens, F1
Eerdekens, K1
Penders, J1
Poesen, K1
Desmet, K1
Vermeersch, P1
Docherty, JR5
Bexis, S4
Silva, R2
Ferreira, LM3
Branco, PS3
Granado, N2
Ares-Santos, S1
Moratalla, R2
Pázmány, P1
Petschner, P1
Ádori, C1
Kirilly, E1
Andó, DR1
Balogh, B1
Gyöngyösi, N1
Bagdy, G1
Kiyatkin, EA5
Kim, AH1
Wakabayashi, KT2
Baumann, MH3
Shaham, Y2
Lizarraga, LE1
Herndon, JM1
Zaretsky, DV1
Zaretskaia, MV1
Durant, PJ1
Rusyniak, DE5
Ren, S1
Coman, D1
Sanganahalli, BG1
Jiang, L1
Hyder, F1
Behar, KL1
Shortall, SE1
Green, AR16
Fone, KC3
King, MV1
Bastos, Mde L1
Ren, SE1
Fonseca, DA1
Guerra, AF1
Antunes, PE1
Antunes, MJ1
Cotrim, MD1
Shioda, K3
Nisijima, K3
Yoshino, T3
Kuboshima, K2
Iwamura, T3
Yui, K1
Kato, S3
Pontes, H2
de Pinho, PG1
Soares, ME1
Dinis-Oliveira, RJ1
Sousa, C1
Carmo, H1
Casal, S1
Remião, F3
O'Shea, E10
Bove, J1
Vila, M1
Colado, MI12
Sharma, HS2
Ali, SF3
Alves, E1
Binienda, Z1
Alves, CJ1
de Lourdes Bastos, M1
Tavares, MA1
Summavielle, T1
Wyeth, RP1
Mills, EM8
Ullman, A1
Kenaston, MA1
Burwell, J1
Tóth, AR1
Varga, T1
Johnson, BN1
Yamamoto, BK5
Bhide, NS1
Lipton, JW1
Cunningham, JI1
Gudelsky, GA6
Orio, L4
Llopis, N1
Torres, E1
Izco, M2
Rodsiri, R2
Marsden, CA3
Piper, BJ1
Daniels, LG1
Meyer, JS2
Touriño, C1
Zimmer, A1
Valverde, O1
Jaehne, EJ2
Majumder, I1
Irvine, RJ3
Vanattou-Saïfoudine, N1
McNamara, R2
Harkin, A2
Pachmerhiwala, R1
Bhide, N1
Straiko, M1
Spicer, C1
Stanich, PP1
Mueller, PS1
Grunau, BE1
Wiens, MO1
Brubacher, JR1
Gilpin, NW1
Wright, MJ1
Dickinson, G1
Vandewater, SA1
Price, JU1
Taffe, MA3
Wallinga, AE1
Grahlmann, C1
Granneman, RA1
Koolhaas, JM1
Buwalda, B1
Kasai, M1
Shen, EY1
Hrometz, SL1
Thatcher, KE1
Ebert, JA1
Parrott, AC2
Papaseit, E1
Vázquez, A1
Pérez-Mañá, C1
Pujadas, M1
de la Torre, R2
Farré, M1
Nolla, J1
Muzzi, M1
Blasi, F1
Masi, A1
Coppi, E1
Traini, C1
Felici, R1
Pittelli, M1
Cavone, L1
Pugliese, AM1
Moroni, F1
Chiarugi, A1
Schütte, JK1
Schäfer, U1
Becker, S1
Oldewurtel, C1
Starosse, A1
Singler, P1
Richard, A1
Wappler, F1
Gerbershagen, MU1
Hare, BD1
D'Onfro, KC1
Hammack, SE1
Falls, WA1
Angoa-Pérez, M1
Kane, MJ1
Briggs, DI1
Francescutti, DM1
Sykes, CE1
Shah, MM1
Thomas, DM1
Kuhn, DM1
Gowing, LR1
Henry-Edwards, SM1
Ali, RL1
Núñez, O1
Bañares, R1
Barrio, J1
Menchén, L1
Diego, Ad1
Salinero, E1
Clemente, G1
Kanthasamy, A1
Shotwell, JR1
Nichols, DE2
Banks, ML2
Cook, VJ1
Blessing, WW4
Seaman, B2
Greene, SL1
Dargan, PI1
O'connor, N1
Jones, AL1
Kerins, M1
Pubill, D2
Canudas, AM1
Pallàs, M1
Camins, A1
Camarasa, J2
Escubedo, E2
McGregor, IS5
Gurtman, CG1
Morley, KC2
Clemens, KJ3
Blokland, A1
Li, KM4
Cornish, JL4
Hunt, GE5
Kunitz, O1
Ince, A1
Kuhlen, R1
Rossaint, R1
Pedersen, NP2
Ootsuka, Y1
Dafters, RI2
Biello, SM1
Dundes, L1
Finkel, T1
Saadat, KS2
Elliott, JM5
Beveridge, TJ1
Mechan, AO3
Sprakes, M1
Pei, Q1
Zetterstrom, TS1
Fantegrossi, WE1
Kiessel, CL1
Leach, PT1
Van Martin, C1
Karabenick, RL1
Chen, X1
Ohizumi, Y1
Ullrich, T2
Rice, KC2
Woods, JH1
Van Nieuwenhuyzen, PS1
Baucum, AJ1
Rau, KS1
Riddle, EL1
Hanson, GR1
Fleckenstein, AE1
Mallet, PE1
Brutcher, RE1
Caden, D2
Sanchez, V3
Pradillo, JM1
Escobedo, I2
Camarero, J2
Moro, MA1
Brown, PL1
Rosa-Neto, P1
Olsen, AK1
Gjedde, A1
Watanabe, H1
Cumming, P2
Gamma, A1
Melian, AM1
Burillo-Putze, G1
Campo, CG1
Padron, AG1
Ramos, CO1
Darvesh, AS2
Leão, A1
Magalhães, J1
Ascensão, A1
Amado, FL1
Vilarinho, L1
Quelhas, D1
Appell, HJ1
Salzmann, J1
Marie-Claire, C1
Noble, F1
Tandy, SL1
Hekmatyar, SK1
Mills, E1
Smith, DJ1
Bansal, N1
MacLellan, D1
Harper, ME1
Morton, J1
Herin, DV1
Liu, S1
Cunningham, KA1
Moze, P1
Holmes, C1
Goldstein, DS1
Jackson, WL1
Reveron, ME1
Duvauchelle, CL1
Meisel, A1
Abreu, AR1
Lobo, AM1
Kerans, A1
O'Neill, B1
Patel, MM1
Belson, MG1
Longwater, AB1
Olson, KR1
Miller, MA1
van Rijswijk, CW1
Kneyber, MC1
Plötz, FB1
Hall, AP2
Henry, JA2
Chang, YJ1
Lai, MW1
Kong, MS1
Chao, HC1
Von Huben, SN1
Lay, CC1
Crean, RD1
Davis, SA1
Katner, SN1
Hamida, SB1
Bach, S1
Plute, E1
Jones, BC3
Kelche, C1
Cassel, JC3
Hargreaves, GA1
Goñi-Allo, B2
Puerta, E2
Hervias, I1
Di Palma, R1
Ramos, M1
Lasheras, B3
Aguirre, N3
Cadet, JL2
Krasnova, IN1
Jayanthi, S1
Lyles, J1
Gramsbergen, JB1
Milani, RM1
Gouzoulis-Mayfrank, E1
Daumann, J1
Martin, TL1
Chiasson, DA1
Kish, SJ1
Weaver, KL1
Abramson, E1
Pfeiffer, M1
Moon, J1
Cros, J1
Ben Hamida, S1
Gordon, CJ1
Strobbe, L1
de Jaer, CP1
Louwerse, ES1
Rozendaal, FW1
O Mathúna, B1
Segura, M1
Clark, RD1
Franken, FH1
Rutter, JJ1
Rothman, RB1
Santos-Marques, MJ1
Williams, JL1
Cross, AJ1
Goodwin, GM1
Watson, JD1
Ferguson, C1
Hinds, CJ1
Skinner, R1
Coakley, JH1
Larner, AJ1
Webb, C1
Williams, V1
McCauley, JC1
Dowsett, RP1
Ellis, AJ1
Wendon, JA1
Portmann, B1
Williams, R1
Coore, JR1
Bodenham, AR2
Mallick, A2
White, SR1
Obradovic, T1
Imel, KM1
Wheaton, MJ1
Dar, KJ1
McBrien, ME1
Johnson, MP1
Schmidt, CJ1
Burnat, P1
Le Brumant-Payen, C1
Huart, B1
Ceppa, F1
Pailler, FM1
Montgomery, H1
Myerson, S1
Cooper, AJ1
Egleston, CV1
Gillman, PK1
Malberg, JE1
Seiden, LS1
Granados, R2
Esteban, B4
Mueller, PD1
Korey, WS1
Byard, RW1
Gilbert, J1
James, R1
Lokan, RJ1
Pennings, EJ1
Konijn, KZ1
de Wolff, FA1
Walubo, A1
Seger, D1
Yeh, SY1
Dersch, C1
Rothman, R1
Barrionuevo, M1
Ramírez, MJ1
Del Río, J1
Ferrie, R1
Loveland, RC1
Burgess, C1
O'Donohoe, A1
Gill, M1
Shankaran, M2
Carvalho, M1
O'Loinsigh, ED1
Boland, G1
Kelly, JP1
O'Boyle, KM1
Vallina Alvarez, E1
Suárez Arias, R1
García Diez, A1
Arribas Castrillo, JM1
Easton, N1
Fry, JR1
Screaton, GR1
Singer, M1
Cairns, HS1
Thrasher, A1
Sarner, M1
Cohen, SL1
Chadwick, IS1
Curry, PD1
Linsley, A1
Freemont, AJ1
Doran, B1
Brown, C1
Osterloh, J1

Reviews

26 reviews available for n-methyl-3,4-methylenedioxyamphetamine and Fever

ArticleYear
Postmortem Hyperthermia: Two Case Reports and a Review of the Literature.
    The American journal of forensic medicine and pathology, 2018, Volume: 39, Issue:4

    Topics: Adult; Drug Overdose; Female; Fever; Humans; Male; Methadone; N-Methyl-3,4-methylenedioxyamphetamine

2018
Ecstasy intoxication as an unusual cause of epileptic seizures in young children.
    European journal of pediatrics, 2013, Volume: 172, Issue:11

    Topics: Female; Fever; Humans; Illicit Drugs; Infant; Male; N-Methyl-3,4-methylenedioxyamphetamine; Seizures

2013
[The cognitive effects of ecstasy].
    Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology, 2013, Volume: 15, Issue:4

    Topics: Cerebrovascular Circulation; Circadian Rhythm; Cognition; Cognition Disorders; Endocannabinoids; Fev

2013
The role of monoamines in the changes in body temperature induced by 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) and its derivatives.
    British journal of pharmacology, 2010, Volume: 160, Issue:5

    Topics: Animals; Biogenic Monoamines; Body Temperature; Dose-Response Relationship, Drug; Fever; Humans; Hyp

2010
Dantrolene in the treatment of MDMA-related hyperpyrexia: a systematic review.
    CJEM, 2010, Volume: 12, Issue:5

    Topics: Clinical Trials as Topic; Dantrolene; Fever; Humans; Muscle Relaxants, Central; N-Methyl-3,4-methyle

2010
MDMA and temperature: a review of the thermal effects of 'Ecstasy' in humans.
    Drug and alcohol dependence, 2012, Feb-01, Volume: 121, Issue:1-2

    Topics: Body Temperature; Body Temperature Regulation; Dancing; Fever; Hallucinogens; Humans; N-Methyl-3,4-m

2012
Environmental conditions modulate neurotoxic effects of psychomotor stimulant drugs of abuse.
    International review of neurobiology, 2012, Volume: 102

    Topics: Animals; Blood-Brain Barrier; Body Temperature; Brain; Brain Edema; Environment; Fever; Hot Temperat

2012
The health effects of ecstasy: a literature review.
    Drug and alcohol review, 2002, Volume: 21, Issue:1

    Topics: Animals; Fever; Humans; Illicit Drugs; N-Methyl-3,4-methylenedioxyamphetamine; Seizures; Substance-R

2002
Neuropharmacology and neurotoxicity of 3,4-methylenedioxymethamphetamine.
    Methods in molecular medicine, 2003, Volume: 79

    Topics: Animals; Brain; Calcium; Dopamine; Fever; Free Radical Scavengers; N-Methyl-3,4-methylenedioxyamphet

2003
The role of the sympathetic nervous system and uncoupling proteins in the thermogenesis induced by 3,4-methylenedioxymethamphetamine.
    Journal of molecular medicine (Berlin, Germany), 2004, Volume: 82, Issue:12

    Topics: Animals; Body Temperature; Carrier Proteins; Fever; Hallucinogens; Humans; Ion Channels; Mitochondri

2004
[Acute and long-term effects of ecstasy].
    Presse medicale (Paris, France : 1983), 2004, Oct-23, Volume: 33, Issue:18 Suppl

    Topics: Animals; Brain Diseases; Chemical and Drug Induced Liver Injury; Fever; Hallucinogens; Humans; N-Met

2004
Ecstasy: pharmacology and neurotoxicity.
    Current opinion in pharmacology, 2005, Volume: 5, Issue:1

    Topics: Affect; Animals; Binding Sites; Brain; Fever; Hallucinogens; Humans; N-Methyl-3,4-methylenedioxyamph

2005
Acute toxic effects of 'Ecstasy' (MDMA) and related compounds: overview of pathophysiology and clinical management.
    British journal of anaesthesia, 2006, Volume: 96, Issue:6

    Topics: Adolescent; Adult; Death, Sudden; Fever; Hallucinogens; Humans; Hyponatremia; Multiple Organ Failure

2006
Neurotoxicity of substituted amphetamines: molecular and cellular mechanisms.
    Neurotoxicity research, 2007, Volume: 11, Issue:3-4

    Topics: Amphetamines; Animals; Apoptosis; Central Nervous System Stimulants; Dopamine; Fever; Humans; Metham

2007
Cannabis and Ecstasy/MDMA (3,4-methylenedioxymethamphetamine): an analysis of their neuropsychobiological interactions in recreational users.
    Journal of neural transmission (Vienna, Austria : 1996), 2007, Volume: 114, Issue:8

    Topics: Animals; Cannabis; Cytoprotection; Drug Interactions; Fever; Hallucinogens; Humans; Marijuana Abuse;

2007
Thermophysiological responses to hyperthermic drugs: extrapolating from rodent to human.
    Progress in brain research, 2007, Volume: 162

    Topics: Adrenergic Uptake Inhibitors; Animals; Body Temperature Regulation; Fever; Humans; N-Methyl-3,4-meth

2007
Review of the pharmacology and clinical pharmacology of 3,4-methylenedioxymethamphetamine (MDMA or "Ecstasy").
    Psychopharmacology, 1995, Volume: 119, Issue:3

    Topics: Animals; Behavior, Animal; Fever; Humans; N-Methyl-3,4-methylenedioxyamphetamine; Serotonin; Tryptop

1995
Exertional heat stroke induced by amphetamine analogues. Does dantrolene have a place?
    Anaesthesia, 1993, Volume: 48, Issue:12

    Topics: 3,4-Methylenedioxyamphetamine; Adolescent; Adult; Blood Coagulation Disorders; Dancing; Dantrolene;

1993
New dimensions in toxicology: hyperthermic syndrome following amphetamine derivatives.
    Intensive care medicine, 1996, Volume: 22, Issue:7

    Topics: Cause of Death; Diagnosis, Differential; Emergencies; Fever; Humans; N-Methyl-3,4-methylenedioxyamph

1996
The effects of methylenedioxymethamphetamine (MDMA, "Ecstasy") on monoaminergic neurotransmission in the central nervous system.
    Progress in neurobiology, 1996, Volume: 49, Issue:5

    Topics: Action Potentials; Animals; Brain; Brain Damage, Chronic; Dopamine; Fever; Guinea Pigs; Haplorhini;

1996
MDMA induced hyperthermia: report of a fatality and review of current therapy.
    Intensive care medicine, 1996, Volume: 22, Issue:9

    Topics: Acute Kidney Injury; Adolescent; Blood Coagulation Disorders; Dantrolene; Fatal Outcome; Fever; Hall

1996
[Ecstasy: psychostimulant, hallucinogen and toxic substance].
    Presse medicale (Paris, France : 1983), 1996, Sep-14, Volume: 25, Issue:26

    Topics: Animals; Central Nervous System; Fever; Hallucinogens; Humans; N-Methyl-3,4-methylenedioxyamphetamin

1996
[Clinical and toxicologic aspects of the use of Ecstasy].
    Nederlands tijdschrift voor geneeskunde, 1998, Aug-29, Volume: 142, Issue:35

    Topics: Animals; Axons; Brain Chemistry; Depression; Female; Fever; Humans; Impulsive Behavior; Inappropriat

1998
Metabolic consequences of drug misuse.
    British journal of anaesthesia, 2000, Volume: 85, Issue:1

    Topics: Cocaine-Related Disorders; Delirium; Fever; Heroin Dependence; Humans; Hyponatremia; N-Methyl-3,4-me

2000
Agony and ecstasy: a review of MDMA effects and toxicity.
    European psychiatry : the journal of the Association of European Psychiatrists, 2000, Volume: 15, Issue:5

    Topics: Acute Disease; Animals; Arrhythmias, Cardiac; Chronic Disease; Fever; Hallucinogens; Humans; Hyponat

2000
[Rhabdomyolysis syndrome and hyperthermia secondary to cocaine and/or ecstasy consumption. Report of 2 new cases and review of the problem].
    Anales de medicina interna (Madrid, Spain : 1984), 2002, Volume: 19, Issue:2

    Topics: Adult; Cocaine; Fever; Humans; Male; N-Methyl-3,4-methylenedioxyamphetamine; Rhabdomyolysis; Syndrom

2002

Other Studies

145 other studies available for n-methyl-3,4-methylenedioxyamphetamine and Fever

ArticleYear
[Fatal serotonin syndrome induced by ecstasy consumption].
    Revue medicale de Liege, 2022, Volume: 77, Issue:1

    Topics: Adult; Emergency Service, Hospital; Fever; Humans; Male; N-Methyl-3,4-methylenedioxyamphetamine; Ser

2022
An unusual route of non-intentional intoxication by ecstasy in a toddler.
    Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 2023, Volume: 30, Issue:4

    Topics: Child; Child, Preschool; Female; Fever; Humans; Hypertension; Mydriasis; N-Methyl-3,4-methylenedioxy

2023
Protracted hyperthermia and delayed rhabdomyolysis in ecstasy toxicity: A case report.
    Medicine, 2020, Oct-09, Volume: 99, Issue:41

    Topics: Drug Overdose; Fever; Fluid Therapy; Humans; Male; N-Methyl-3,4-methylenedioxyamphetamine; Rhabdomyo

2020
Isolated non-cardiogenic pulmonary edema - A rare complication of MDMA toxicity.
    The American journal of emergency medicine, 2017, Volume: 35, Issue:9

    Topics: Fever; Holidays; Humans; Intubation, Intratracheal; Male; N-Methyl-3,4-methylenedioxyamphetamine; Pu

2017
Too Hot to Handle: A Case Report of Extreme Pyrexia After MDMA Ingestion.
    Therapeutic hypothermia and temperature management, 2018, Volume: 8, Issue:3

    Topics: Adolescent; Fever; Hallucinogens; Humans; Hypothermia, Induced; Male; N-Methyl-3,4-methylenedioxyamp

2018
Aged rats are more vulnerable than adolescents to "ecstasy"-induced toxicity.
    Archives of toxicology, 2018, Volume: 92, Issue:7

    Topics: Aging; Animals; Brain; Dopamine; Fever; Heart; Liver; Male; N-Methyl-3,4-methylenedioxyamphetamine;

2018
The influence of the host microbiome on 3,4-methylenedioxymethamphetamine (MDMA)-induced hyperthermia and vice versa.
    Scientific reports, 2019, 03-13, Volume: 9, Issue:1

    Topics: Animals; Fever; Hyperthermia, Induced; Male; Microbiota; N-Methyl-3,4-methylenedioxyamphetamine; Pro

2019
Concurrent Inhibition of Vesicular Monoamine Transporter 2 Does Not Protect Against 3,4-Methylenedioxymethamphetamine (Ecstasy) Induced Neurotoxicity.
    Toxicological sciences : an official journal of the Society of Toxicology, 2019, 07-01, Volume: 170, Issue:1

    Topics: 2H-Benzo(a)quinolizin-2-ol, 2-Ethyl-1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy-; Animals; Bod

2019
Minocycline attenuates 3,4-methylenedioxymethamphetamine-induced hyperthermia in the rat brain.
    European journal of pharmacology, 2019, Sep-05, Volume: 858

    Topics: Animals; Body Temperature; Brain; Fever; Heart Rate; Locomotion; Male; Minocycline; N-Methyl-3,4-met

2019
Influence of ketanserin on the effects of methylenedioxymethamphetamine on body temperature in the mouse.
    Autonomic & autacoid pharmacology, 2013, Volume: 33, Issue:3-4

    Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic Uptake Inhibitors; Animals; Aorta; Body Temperat

2013
"Ecstasy"-induced toxicity in SH-SY5Y differentiated cells: role of hyperthermia and metabolites.
    Archives of toxicology, 2014, Volume: 88, Issue:2

    Topics: 3,4-Methylenedioxyamphetamine; Acetylcysteine; Caspase 3; Cell Death; Cell Differentiation; Cell Lin

2014
D1 but not D4 dopamine receptors are critical for MDMA-induced neurotoxicity in mice.
    Neurotoxicity research, 2014, Volume: 25, Issue:1

    Topics: Animals; Corpus Striatum; Dopamine; Female; Fever; Male; Mice; Mice, Knockout; N-Methyl-3,4-methylen

2014
Critical role of peripheral vasoconstriction in fatal brain hyperthermia induced by MDMA (Ecstasy) under conditions that mimic human drug use.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014, Jun-04, Volume: 34, Issue:23

    Topics: Animals; Body Temperature; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Fever; H

2014
Vesicular monoamine transporter 2 and the acute and long-term response to 3,4-(±)-methylenedioxymethamphetamine.
    Toxicological sciences : an official journal of the Society of Toxicology, 2015, Volume: 143, Issue:1

    Topics: 2H-Benzo(a)quinolizin-2-ol, 2-Ethyl-1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy-; Animals; Beh

2015
Treadmill running restores MDMA-mediated hyperthermia prevented by inhibition of the dorsomedial hypothalamus.
    Brain research, 2015, May-22, Volume: 1608

    Topics: Analysis of Variance; Animals; Body Temperature; Exercise Test; Fever; GABA-A Receptor Agonists; Hal

2015
Clinically Relevant Pharmacological Strategies That Reverse MDMA-Induced Brain Hyperthermia Potentiated by Social Interaction.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2016, Volume: 41, Issue:2

    Topics: Animals; Antipsychotic Agents; Body Temperature; Brain; Carbazoles; Carvedilol; Clozapine; Fever; Ha

2016
Distribution of temperature changes and neurovascular coupling in rat brain following 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") exposure.
    NMR in biomedicine, 2015, Volume: 28, Issue:10

    Topics: Anesthesia, General; Animals; Body Temperature; Brain; Cerebral Cortex; Fever; Magnetic Resonance Sp

2015
Caffeine alters the behavioural and body temperature responses to mephedrone without causing long-term neurotoxicity in rats.
    Journal of psychopharmacology (Oxford, England), 2016, Volume: 30, Issue:7

    Topics: Animals; Behavior, Animal; Body Temperature; Brain; Caffeine; Discrimination, Psychological; Dopamin

2016
"Ecstasy" toxicity to adolescent rats following an acute low binge dose.
    BMC pharmacology & toxicology, 2016, 06-28, Volume: 17, Issue:1

    Topics: Adenosine Triphosphate; Age Factors; Animals; Brain; Dose-Response Relationship, Drug; Fever; Halluc

2016
MDMA, Methylone, and MDPV: Drug-Induced Brain Hyperthermia and Its Modulation by Activity State and Environment.
    Current topics in behavioral neurosciences, 2017, Volume: 32

    Topics: Animals; Antipsychotic Agents; Benzodioxoles; Body Temperature; Brain; Carbazoles; Carvedilol; Centr

2017
Hyperthermia Severely Affects the Vascular Effects of MDMA and Metabolites in the Human Internal Mammary Artery In Vitro.
    Cardiovascular toxicology, 2017, Volume: 17, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Dose-Response Relationship, Drug; Female; Fever; Humans; Male; Mamma

2017
Risperidone attenuates and reverses hyperthermia induced by 3,4-methylenedioxymethamphetamine (MDMA) in rats.
    Neurotoxicology, 2008, Volume: 29, Issue:6

    Topics: Analysis of Variance; Animals; Body Temperature; Disease Models, Animal; Dopamine; Dopamine Antagoni

2008
Chronic exposure to ethanol exacerbates MDMA-induced hyperthermia and exposes liver to severe MDMA-induced toxicity in CD1 mice.
    Toxicology, 2008, Oct-30, Volume: 252, Issue:1-3

    Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Body Temperature; Central

2008
Persistent MDMA-induced dopaminergic neurotoxicity in the striatum and substantia nigra of mice.
    Journal of neurochemistry, 2008, Volume: 107, Issue:4

    Topics: Animals; Cell Death; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dose-Re

2008
Acute administration of 3,4-methylenedioxymethamphetamine induces profound hyperthermia, blood-brain barrier disruption, brain edema formation, and cell injury.
    Annals of the New York Academy of Sciences, 2008, Volume: 1139

    Topics: Albumins; Animals; Astrocytes; Behavior, Animal; Blood-Brain Barrier; Body Temperature; Brain Edema;

2008
Acetyl-L-carnitine provides effective in vivo neuroprotection over 3,4-methylenedioximethamphetamine-induced mitochondrial neurotoxicity in the adolescent rat brain.
    Neuroscience, 2009, Jan-23, Volume: 158, Issue:2

    Topics: Acetylcarnitine; Animals; Body Weight; Brain; Cyclooxygenase 1; DNA, Mitochondrial; Fever; Hallucino

2009
The hyperthermia mediated by 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy) is sensitive to sex differences.
    Toxicology and applied pharmacology, 2009, Feb-15, Volume: 235, Issue:1

    Topics: Adrenergic alpha-1 Receptor Agonists; Animals; Aorta; Female; Fever; Gene Expression Regulation; Hal

2009
Myocardium and striated muscle damage caused by licit or illicit drugs.
    Legal medicine (Tokyo, Japan), 2009, Volume: 11 Suppl 1

    Topics: Adolescent; Adult; Alprazolam; Anticonvulsants; Brain Edema; Clonazepam; Creatine Kinase; Female; Fe

2009
Chronic unpredictable stress augments +3,4-methylenedioxymethamphetamine-induced monoamine depletions: the role of corticosterone.
    Neuroscience, 2009, Apr-10, Volume: 159, Issue:4

    Topics: Animals; Body Temperature; Brain; Corpus Striatum; Corticosterone; Dopamine; Enzyme Inhibitors; Feve

2009
Role of alpha 1- and beta 3-adrenoceptors in the modulation by SR59230A of the effects of MDMA on body temperature in the mouse.
    British journal of pharmacology, 2009, Volume: 158, Issue:1

    Topics: Adrenergic beta-3 Receptor Antagonists; Animals; Body Temperature; Fever; In Vitro Techniques; Male;

2009
Repeated exposure to MDMA provides neuroprotection against subsequent MDMA-induced serotonin depletion in brain.
    Brain research, 2009, Aug-25, Volume: 1286

    Topics: Adrenergic Uptake Inhibitors; Animals; Blotting, Western; Brain; Dopamine; Drug Tolerance; Fever; Me

2009
A study on the mechanisms by which minocycline protects against MDMA ('ecstasy')-induced neurotoxicity of 5-HT cortical neurons.
    Neurotoxicity research, 2010, Volume: 18, Issue:2

    Topics: Animals; Drug Administration Schedule; Fever; Frontal Lobe; Hypothalamus; Inflammation; Interleukin-

2010
Effect of acute brain tyrosine depletion on MDMA-induced changes in brain 5-HT.
    Journal of psychopharmacology (Oxford, England), 2010, Volume: 24, Issue:2

    Topics: Animals; Corpus Striatum; Dopamine; Fever; Hippocampus; Male; N-Methyl-3,4-methylenedioxyamphetamine

2010
Repeated intermittent methylenedioxymethamphetamine exposure protects against the behavioral and neurotoxic, but not hyperthermic, effects of an MDMA binge in adult rats.
    Synapse (New York, N.Y.), 2010, Volume: 64, Issue:6

    Topics: Age Factors; Animals; Binding, Competitive; Body Temperature; Cerebral Cortex; Citalopram; Dose-Resp

2010
THC Prevents MDMA Neurotoxicity in Mice.
    PloS one, 2010, Feb-10, Volume: 5, Issue:2

    Topics: Animals; Astrocytes; Body Temperature; Dronabinol; Fever; Hallucinogens; Indoles; Mice; Mice, Inbred

2010
Increased effects of 3,4-methylenedioxymethamphetamine (ecstasy) in a rat model of depression.
    Addiction biology, 2011, Volume: 16, Issue:1

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Arousal; Body Temperature Regulation; Brain; Cerebral Corte

2011
Mechanisms mediating the ability of caffeine to influence MDMA ('Ecstasy')-induced hyperthermia in rats.
    British journal of pharmacology, 2010, Volume: 160, Issue:4

    Topics: Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Adrenergic alpha-Antagonists;

2010
Role of serotonin and/or norepinephrine in the MDMA-induced increase in extracellular glucose and glycogenolysis in the rat brain.
    European journal of pharmacology, 2010, Oct-10, Volume: 644, Issue:1-3

    Topics: Animals; Brain; Fever; Fluoxetine; Glucose; Glycogenolysis; Male; N-Methyl-3,4-methylenedioxyampheta

2010
Acute concomitant effects of MDMA binge dosing on extracellular 5-HT, locomotion and body temperature and the long-term effect on novel object discrimination in rats.
    Psychopharmacology, 2011, Volume: 213, Issue:2-3

    Topics: Animals; Body Temperature; Discrimination Learning; Dose-Response Relationship, Drug; Drug Administr

2011
21-year-old woman with palpitations and vomiting.
    Mayo Clinic proceedings, 2010, Volume: 85, Issue:9

    Topics: Diagnosis, Differential; Female; Fever; Humans; Illicit Drugs; N-Methyl-3,4-methylenedioxyamphetamin

2010
Influences of activity wheel access on the body temperature response to MDMA and methamphetamine.
    Pharmacology, biochemistry, and behavior, 2011, Volume: 99, Issue:3

    Topics: Animals; Behavior, Animal; Body Temperature; Dose-Response Relationship, Drug; Fever; Male; Methamph

2011
Gender differences in hyperthermia and regional 5-HT and 5-HIAA depletion in the brain following MDMA administration in rats.
    Brain research, 2011, Jun-29, Volume: 1398

    Topics: Animals; Brain; Disease Models, Animal; Female; Fever; Hydroxyindoleacetic Acid; Male; N-Methyl-3,4-

2011
The effects of mirtazapine and fluoxetine on hyperthermia induced by 3,4-methylenedioxymethamphetamine (MDMA) in rats.
    Neuroscience letters, 2011, Jul-15, Volume: 499, Issue:1

    Topics: Animals; Antidepressive Agents, Tricyclic; Disease Models, Animal; Fever; Fluoxetine; Male; Mianseri

2011
Chronic administration of THC prevents the behavioral effects of intermittent adolescent MDMA administration and attenuates MDMA-induced hyperthermia and neurotoxicity in rats.
    Neuropharmacology, 2011, Volume: 61, Issue:8

    Topics: Adrenergic Uptake Inhibitors; Age Factors; Analysis of Variance; Animals; Animals, Newborn; Behavior

2011
Identification of a possible role for atrial natriuretic peptide in MDMA-induced hyperthermia.
    Toxicology letters, 2011, Oct-10, Volume: 206, Issue:2

    Topics: Animals; Antipyretics; Atrial Natriuretic Factor; Body Temperature Regulation; Fever; Hallucinogens;

2011
Δ9-Tetrahydrocannabinol attenuates MDMA-induced hyperthermia in rhesus monkeys.
    Neuroscience, 2012, Jan-10, Volume: 201

    Topics: Analgesics, Non-Narcotic; Analysis of Variance; Animals; Body Temperature; Cannabinoid Receptor Anta

2012
Surviving life-threatening MDMA (3,4-methylenedioxymethamphetamine, ecstasy) toxicity caused by ritonavir (RTV).
    Intensive care medicine, 2012, Volume: 38, Issue:7

    Topics: Blood Component Transfusion; Contraindications; Drug Interactions; Fever; Fluid Therapy; Hallucinoge

2012
Neurological basis of AMP-dependent thermoregulation and its relevance to central and peripheral hyperthermia.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2013, Volume: 33, Issue:2

    Topics: 5'-Nucleotidase; Adenosine Monophosphate; Adrenergic Uptake Inhibitors; Animals; Body Temperature Re

2013
3,4-Methylenedioxymethamphetamine induces a hyperthermic and hypermetabolic crisis in pigs with and without a genetic disposition for malignant hyperthermia.
    European journal of anaesthesiology, 2013, Volume: 30, Issue:1

    Topics: Acidosis; Animals; Dantrolene; Fatty Acids, Nonesterified; Fever; Genetic Predisposition to Disease;

2013
Memantine attenuates 3,4-methylenedioxymethamphetamine-induced hyperthermia in rats.
    Neuroscience letters, 2012, Dec-07, Volume: 531, Issue:2

    Topics: Animals; Brain Chemistry; Chromatography, High Pressure Liquid; Dopamine; Dopamine Agents; Fever; Ha

2012
Prior stress interferes with the anxiolytic effect of exercise in C57BL/6J mice.
    Behavioral neuroscience, 2012, Volume: 126, Issue:6

    Topics: Animals; Anti-Anxiety Agents; Anxiety; Fever; Male; Mice; Mice, Inbred C57BL; Motor Activity; N-Meth

2012
Mephedrone does not damage dopamine nerve endings of the striatum, but enhances the neurotoxicity of methamphetamine, amphetamine, and MDMA.
    Journal of neurochemistry, 2013, Volume: 125, Issue:1

    Topics: Amphetamine; Animals; Corpus Striatum; Dopamine; Drug Synergism; Female; Fever; Methamphetamine; Mic

2013
[Variability of the clinical expression of Ecstasy-induced hepatotoxicity].
    Gastroenterologia y hepatologia, 2002, Volume: 25, Issue:8

    Topics: Abdominal Pain; Adolescent; Adult; Biopsy; Chemical and Drug Induced Liver Injury; Cholestasis, Intr

2002
Unilateral infusion of a dopamine transporter antisense into the substantia nigra protects against MDMA-induced serotonergic deficits in the ipsilateral striatum.
    Neuroscience, 2002, Volume: 114, Issue:4

    Topics: Animals; Carrier Proteins; Corpus Striatum; Dopamine Plasma Membrane Transport Proteins; Dopamine Up

2002
Hypothalamic-pituitary-thyroid axis and sympathetic nervous system involvement in hyperthermia induced by 3,4-methylenedioxymethamphetamine (Ecstasy).
    The Journal of pharmacology and experimental therapeutics, 2003, Volume: 305, Issue:1

    Topics: 3,4-Methylenedioxyamphetamine; Adrenergic alpha-Antagonists; Animals; Drug Interactions; Fever; Hypo

2003
5-hydroxytryptamine(2A) receptors regulate sympathetic nerves constricting the cutaneous vascular bed in rabbits and rats.
    Neuroscience, 2003, Volume: 117, Issue:4

    Topics: Animals; Blood Pressure; Blood Vessels; Body Temperature; Dose-Response Relationship, Drug; Fever; H

2003
Multiple toxicity from 3,4-methylenedioxymethamphetamine ("ecstasy").
    The American journal of emergency medicine, 2003, Volume: 21, Issue:2

    Topics: Adolescent; Adult; Fatal Outcome; Female; Fever; Humans; Liver Failure; Male; N-Methyl-3,4-methylene

2003
Different glial response to methamphetamine- and methylenedioxymethamphetamine-induced neurotoxicity.
    Naunyn-Schmiedeberg's archives of pharmacology, 2003, Volume: 367, Issue:5

    Topics: Animals; Binding Sites; Body Weight; Brain; Carrier Proteins; Central Nervous System Diseases; Dopam

2003
Increased anxiety and "depressive" symptoms months after MDMA ("ecstasy") in rats: drug-induced hyperthermia does not predict long-term outcomes.
    Psychopharmacology, 2003, Volume: 168, Issue:4

    Topics: Amygdala; Animals; Anxiety; Biogenic Monoamines; Cognition; Corpus Striatum; Depression; Fever; Hipp

2003
[Hyperpyrexia and rhabdomyolysis after ecstasy (MDMA) intoxication].
    Der Anaesthesist, 2003, Volume: 52, Issue:6

    Topics: Acute Kidney Injury; Adult; Disseminated Intravascular Coagulation; Diuresis; Fever; Hallucinogens;

2003
Clozapine reverses hyperthermia and sympathetically mediated cutaneous vasoconstriction induced by 3,4-methylenedioxymethamphetamine (ecstasy) in rabbits and rats.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003, Jul-16, Volume: 23, Issue:15

    Topics: Anesthesia; Animals; Antipsychotic Agents; Benzodiazepines; Body Temperature; Clozapine; Disease Mod

2003
The effect of 3,4-methylenedioxymethamphetamine ('Ecstasy') on serotonergic regulation of the mammalian circadian clock mechanism in rats: the role of dopamine and hyperthermia.
    Neuroscience letters, 2003, Oct-23, Volume: 350, Issue:2

    Topics: Animals; Body Temperature; Circadian Rhythm; Dopamine; Dopamine Antagonists; Fever; Male; N-Methyl-3

2003
DanceSafe and ecstasy: protection or promotion?
    Journal of health & social policy, 2003, Volume: 17, Issue:1

    Topics: Adolescent; Adult; Fear; Female; Fever; Harm Reduction; Health Behavior; Humans; Male; N-Methyl-3,4-

2003
Pharmacology: uncoupling the agony from ecstasy.
    Nature, 2003, Nov-27, Volume: 426, Issue:6965

    Topics: Animals; Body Temperature; Body Temperature Regulation; Carrier Proteins; Fever; Gene Deletion; Ion

2003
New treatment for Ecstasy-related hyperthermia.
    Internal medicine journal, 2003, Volume: 33, Issue:12

    Topics: Animals; Antipsychotic Agents; Benzodiazepines; Clozapine; Disease Models, Animal; Fever; Humans; N-

2003
Hyperthermic and neurotoxic effect of 3,4-methylenedioxymethamphetamine (MDMA) in guinea pigs.
    Psychopharmacology, 2004, Volume: 173, Issue:3-4

    Topics: Animals; Corpus Striatum; Dopamine; Dopamine Agents; Fever; Guinea Pigs; Male; N-Methyl-3,4-methylen

2004
Effect of 5-HT depletion by MDMA on hyperthermia and Arc mRNA induction in rat brain.
    Psychopharmacology, 2004, Volume: 173, Issue:3-4

    Topics: Animals; Brain; Cytoskeletal Proteins; Fever; Immediate-Early Proteins; In Situ Hybridization; Male;

2004
Nantenine: an antagonist of the behavioral and physiological effects of MDMA in mice.
    Psychopharmacology, 2004, Volume: 173, Issue:3-4

    Topics: Adrenergic alpha-Antagonists; Animals; Aporphines; Behavior, Animal; Crowding; Dose-Response Relatio

2004
MDMA ("ecstasy"), methamphetamine and their combination: long-term changes in social interaction and neurochemistry in the rat.
    Psychopharmacology, 2004, Volume: 173, Issue:3-4

    Topics: Animals; Anxiety; Behavior, Animal; Body Temperature; Corpus Striatum; Dopamine; Dopamine Agents; Dr

2004
Methamphetamine increases dopamine transporter higher molecular weight complex formation via a dopamine- and hyperthermia-associated mechanism.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004, Mar-31, Volume: 24, Issue:13

    Topics: Adrenergic Uptake Inhibitors; Amphetamine-Related Disorders; Animals; Blotting, Western; Dopamine; D

2004
Cannabinoids prevent the acute hyperthermia and partially protect against the 5-HT depleting effects of MDMA ("Ecstasy") in rats.
    Neuropharmacology, 2004, Volume: 46, Issue:7

    Topics: Animals; Cannabinoids; Cyclohexanols; Fever; Male; Motor Activity; N-Methyl-3,4-methylenedioxyamphet

2004
Attenuation of 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy)-induced rhabdomyolysis with alpha1- plus beta3-adrenoreceptor antagonists.
    British journal of pharmacology, 2004, Volume: 142, Issue:4

    Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic beta-3 Receptor Antagonists; Animals; Blood Urea

2004
3,4-Methylenedioxymethamphetamine increases interleukin-1beta levels and activates microglia in rat brain: studies on the relationship with acute hyperthermia and 5-HT depletion.
    Journal of neurochemistry, 2004, Volume: 89, Issue:6

    Topics: Acute Disease; Animals; Astrocytes; Binding, Competitive; Body Temperature; Brain; Cerebral Cortex;

2004
Brain hyperthermia induced by MDMA (ecstasy): modulation by environmental conditions.
    The European journal of neuroscience, 2004, Volume: 20, Issue:1

    Topics: Animals; Body Temperature; Body Temperature Regulation; Brain; Environment; Female; Fever; Hallucino

2004
MDMA-evoked changes in cerebral blood flow in living porcine brain: correlation with hyperthermia.
    Synapse (New York, N.Y.), 2004, Sep-15, Volume: 53, Issue:4

    Topics: Animals; Brain; Cerebral Arteries; Cerebrovascular Circulation; Disease Models, Animal; Female; Feve

2004
Keeping a clear head on effects of illicit drugs.
    Nature, 2004, Jul-22, Volume: 430, Issue:6998

    Topics: Bias; Clinical Trials, Phase I as Topic; Controlled Clinical Trials as Topic; Fever; Humans; Illicit

2004
Accidental ecstasy poisoning in a toddler.
    Pediatric emergency care, 2004, Volume: 20, Issue:8

    Topics: Accidents, Home; Benzodiazepines; Cardiac Complexes, Premature; Combined Modality Therapy; Fever; Hu

2004
Evidence for the involvement of nitric oxide in 3,4-methylenedioxymethamphetamine-induced serotonin depletion in the rat brain.
    The Journal of pharmacology and experimental therapeutics, 2005, Volume: 312, Issue:2

    Topics: Animals; Brain Chemistry; Citrulline; Dopamine; Enzyme Inhibitors; Fever; Male; Malonates; Microdial

2005
Strenuous exercise aggravates MDMA-induced skeletal muscle damage in mice.
    Toxicology, 2005, Jan-31, Volume: 206, Issue:3

    Topics: Animals; Body Temperature; Fever; Hallucinogens; Male; Mice; Microscopy, Electron, Transmission; Mot

2005
The role of mitochondrial uncoupling in 3,4-methylenedioxymethamphetamine-mediated skeletal muscle hyperthermia and rhabdomyolysis.
    The Journal of pharmacology and experimental therapeutics, 2005, Volume: 313, Issue:2

    Topics: Animals; Carrier Proteins; Dose-Response Relationship, Drug; Fever; Ion Channels; Male; Membrane Pro

2005
The role of 5-HT in the impairment of thermoregulation observed in rats administered MDMA ('ecstasy') when housed at high ambient temperature.
    Psychopharmacology, 2005, Volume: 179, Issue:4

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Biogenic Monoamines; Body Temperature Regulation; B

2005
Role of the serotonin 5-HT2A receptor in the hyperlocomotive and hyperthermic effects of (+)-3,4-methylenedioxymethamphetamine.
    Psychopharmacology, 2005, Volume: 178, Issue:4

    Topics: Animals; Dose-Response Relationship, Drug; Drug Antagonism; Drug Therapy, Combination; Fever; Fluoro

2005
Carvedilol reverses hyperthermia and attenuates rhabdomyolysis induced by 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy) in an animal model.
    Critical care medicine, 2005, Volume: 33, Issue:6

    Topics: Adrenergic beta-Antagonists; Analysis of Variance; Animals; Carbazoles; Carvedilol; Catecholamines;

2005
Toward directed therapy for amphetamine-mediated hyperthermia: is carvedilol worth raving about?
    Critical care medicine, 2005, Volume: 33, Issue:6

    Topics: Adrenergic beta-Antagonists; Amphetamines; Animals; Carbazoles; Carvedilol; Fever; Humans; N-Methyl-

2005
MDMA ('Ecstasy') and methamphetamine combined: order of administration influences hyperthermic and long-term adverse effects in female rats.
    Neuropharmacology, 2005, Volume: 49, Issue:2

    Topics: Animals; Behavior, Animal; Body Temperature; Brain; Brain Chemistry; Central Nervous System Stimulan

2005
Age-dependent (+)MDMA-mediated neurotoxicity in mice.
    Neurotoxicology, 2005, Volume: 26, Issue:6

    Topics: Aging; Animals; Body Temperature; Brain; Dopamine Plasma Membrane Transport Proteins; Fever; Halluci

2005
Role of alpha2A-adrenoceptors in the effects of MDMA on body temperature in the mouse.
    British journal of pharmacology, 2005, Volume: 146, Issue:1

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Animals; Body

2005
3,4-Methylenedioxymethamphetamine increases pro-interleukin-1beta production and caspase-1 protease activity in frontal cortex, but not in hypothalamus, of Dark Agouti rats: role of interleukin-1beta in neurotoxicity.
    Neuroscience, 2005, Volume: 135, Issue:4

    Topics: Animals; Blotting, Western; Caspase 1; Chromatography, High Pressure Liquid; Fever; Frontal Lobe; Ha

2005
Neurotoxicity of Ecstasy metabolites in rat cortical neurons, and influence of hyperthermia.
    The Journal of pharmacology and experimental therapeutics, 2006, Volume: 316, Issue:1

    Topics: Acetylcysteine; Acridine Orange; Animals; Cell Death; Cells, Cultured; Cerebral Cortex; Culture Medi

2006
Caffeine promotes hyperthermia and serotonergic loss following co-administration of the substituted amphetamines, MDMA ("Ecstasy") and MDA ("Love").
    Neuropharmacology, 2006, Volume: 50, Issue:1

    Topics: 3,4-Methylenedioxyamphetamine; Animals; Area Under Curve; Behavior, Animal; Body Temperature; Brain

2006
Methylenedioxymethamphetamine (ecstasy)-related hyperthermia.
    The Journal of emergency medicine, 2005, Volume: 29, Issue:4

    Topics: Adolescent; Adrenergic Uptake Inhibitors; Adult; Fatal Outcome; Female; Fever; Hallucinogens; Humans

2005
Accidental ecstasy intoxication in an 8-month-old infant.
    Intensive care medicine, 2006, Volume: 32, Issue:4

    Topics: Drug Overdose; Fever; Humans; Hypertension; Infant; N-Methyl-3,4-methylenedioxyamphetamine; Netherla

2006
Accidental ingestion of Ecstasy in a toddler.
    Journal of the Formosan Medical Association = Taiwan yi zhi, 2005, Volume: 104, Issue:12

    Topics: Diagnosis, Differential; Fever; Humans; Hypertension; Infant; Male; N-Methyl-3,4-methylenedioxyamphe

2005
Impact of ambient temperature on hyperthermia induced by (+/-)3,4-methylenedioxymethamphetamine in rhesus macaques.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2007, Volume: 32, Issue:3

    Topics: Animals; Body Temperature; Body Temperature Regulation; Dose-Response Relationship, Drug; Drug Deliv

2007
Ethanol-ecstasy (MDMA) interactions in rats: preserved attenuation of hyperthermia and potentiation of hyperactivity by ethanol despite prior ethanol treatment.
    Pharmacology, biochemistry, and behavior, 2006, Volume: 84, Issue:1

    Topics: Animals; Body Temperature; Ethanol; Fever; Male; Motor Activity; N-Methyl-3,4-methylenedioxyamphetam

2006
Association of caffeine to MDMA does not increase antinociception but potentiates adverse effects of this recreational drug.
    Brain research, 2006, Sep-21, Volume: 1111, Issue:1

    Topics: Analgesics; Animals; Body Temperature; Brain; Caffeine; Central Nervous System Stimulants; Disease M

2006
Binge ethanol administration enhances the MDMA-induced long-term 5-HT neurotoxicity in rat brain.
    Psychopharmacology, 2007, Volume: 189, Issue:4

    Topics: Acetaldehyde; Alcoholic Intoxication; Aldehyde Dehydrogenase; Animals; Body Temperature; Brain; Cent

2007
Ethanol and MDMA: a comment on the paper by Izco et al.
    Psychopharmacology, 2007, Volume: 191, Issue:2

    Topics: Alcoholic Intoxication; Animals; Body Temperature; Brain; Central Nervous System Depressants; Drug S

2007
High ambient temperature increases 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy")-induced Fos expression in a region-specific manner.
    Neuroscience, 2007, Mar-16, Volume: 145, Issue:2

    Topics: Adrenergic Uptake Inhibitors; Animals; Biomarkers; Body Temperature; Body Temperature Regulation; Br

2007
Studies on the mechanisms underlying amiloride enhancement of 3,4-methylenedioxymethamphetamine-induced serotonin depletion in rats.
    European journal of pharmacology, 2007, May-21, Volume: 562, Issue:3

    Topics: Amiloride; Animals; Body Temperature; Corpus Striatum; Drug Synergism; Fever; Hallucinogens; Male; N

2007
Serotonin mediates rapid changes of striatal glucose and lactate metabolism after systemic 3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") administration in awake rats.
    Neurochemistry international, 2007, Volume: 51, Issue:1

    Topics: Animals; Body Temperature; Corpus Striatum; Dose-Response Relationship, Drug; Energy Metabolism; Ext

2007
Does hyperthyroidism increase risk of death due to the ingestion of ecstasy?
    Journal of forensic sciences, 2007, Volume: 52, Issue:4

    Topics: Adult; Fatal Outcome; Female; Fever; Forensic Toxicology; Hallucinogens; Humans; Hyperthyroidism; N-

2007
Pharmacological and behavioral determinants of cocaine, methamphetamine, 3,4-methylenedioxymethamphetamine, and para-methoxyamphetamine-induced hyperthermia.
    Psychopharmacology, 2007, Volume: 194, Issue:1

    Topics: Amphetamines; Animals; Behavior, Animal; Body Temperature Regulation; Central Nervous System Stimula

2007
Influence of dietary fats on Ecstasy-induced hyperthermia.
    British journal of pharmacology, 2007, Volume: 151, Issue:7

    Topics: Adipose Tissue, Brown; Analysis of Variance; Animals; Blotting, Western; Body Temperature; Diet, Fat

2007
Role of dantrolene in the management of the acute toxic effects of Ecstasy (MDMA).
    British journal of anaesthesia, 2007, Volume: 99, Issue:1

    Topics: Acute Disease; Adult; Dantrolene; Fever; Hallucinogens; Humans; Male; Muscle Relaxants, Central; N-M

2007
Attenuation of MDMA-induced hyperthermia by ethanol in rats depends on ambient temperature.
    European journal of pharmacology, 2007, Oct-01, Volume: 571, Issue:2-3

    Topics: Analgesics, Non-Narcotic; Animals; Body Temperature; Disease Models, Animal; Ethanol; Fever; Male; N

2007
[Fatal ecstasy intoxication in a 22-year-old man].
    Nederlands tijdschrift voor geneeskunde, 2007, Jul-28, Volume: 151, Issue:30

    Topics: Adult; Fatal Outcome; Fever; Hallucinogens; Humans; Male; Multiple Organ Failure; N-Methyl-3,4-methy

2007
Role of alpha1-adrenoceptor subtypes in the effects of methylenedioxy methamphetamine (MDMA) on body temperature in the mouse.
    British journal of pharmacology, 2008, Volume: 153, Issue:3

    Topics: Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Animals; Body Temperature; Fever; Male;

2008
The relationship between core body temperature and 3,4-methylenedioxymethamphetamine metabolism in rats: implications for neurotoxicity.
    Psychopharmacology, 2008, Volume: 197, Issue:2

    Topics: Animals; Body Temperature; Brain Chemistry; Catechol O-Methyltransferase; Catechol O-Methyltransfera

2008
Tolerance to 3,4-methylenedioxymethamphetamine in rats exposed to single high-dose binges.
    Neuroscience, 2008, Mar-27, Volume: 152, Issue:3

    Topics: Animals; Body Temperature; Brain; Dopamine; Dose-Response Relationship, Drug; Down-Regulation; Drug

2008
Effect of chronic ethanol exposure on the hepatotoxicity of ecstasy in mice: an ex vivo study.
    Toxicology in vitro : an international journal published in association with BIBRA, 2008, Volume: 22, Issue:4

    Topics: Adenosine Triphosphate; Alcohol Drinking; Animals; Cell Survival; Collagen; Dose-Response Relationsh

2008
The hyperthermic and neurotoxic effects of 'Ecstasy' (MDMA) and 3,4 methylenedioxyamphetamine (MDA) in the Dark Agouti (DA) rat, a model of the CYP2D6 poor metabolizer phenotype.
    British journal of pharmacology, 1995, Volume: 115, Issue:7

    Topics: 3,4-Methylenedioxyamphetamine; Animals; Body Temperature Regulation; Brain; Cytochrome P-450 CYP2D6;

1995
Dantrolene and 'ecstasy' overdose.
    Anaesthesia, 1993, Volume: 48, Issue:2

    Topics: 3,4-Methylenedioxyamphetamine; Dantrolene; Designer Drugs; Fever; Humans; N-Methyl-3,4-methylenediox

1993
Ecstasy intoxication: appreciation of complications and the role of dantrolene.
    Anaesthesia, 1993, Volume: 48, Issue:6

    Topics: 3,4-Methylenedioxyamphetamine; Adult; Dantrolene; Designer Drugs; Fever; Humans; Male; N-Methyl-3,4-

1993
Deaths attributed to an "ecstasy" overdose.
    The Medical journal of Australia, 1996, Jan-01, Volume: 164, Issue:1

    Topics: Dantrolene; Drug Overdose; Female; Fever; Hallucinogens; Humans; N-Methyl-3,4-methylenedioxyamphetam

1996
Hyperthermia following MDMA administration in rats: effects of ambient temperature, water consumption, and chronic dosing.
    Physiology & behavior, 1995, Volume: 58, Issue:5

    Topics: Animals; Body Temperature; Drinking; Fever; Hyperkinesis; Male; Motor Activity; N-Methyl-3,4-methyle

1995
Deaths attributed to "ecstasy" overdose.
    The Medical journal of Australia, 1996, Jun-03, Volume: 164, Issue:11

    Topics: Dantrolene; Drug Overdose; Fever; Hallucinogens; Humans; N-Methyl-3,4-methylenedioxyamphetamine

1996
Acute liver damage and ecstasy ingestion.
    Gut, 1996, Volume: 38, Issue:3

    Topics: Adolescent; Adult; Fatal Outcome; Female; Fever; Humans; Hypotension; Liver; Liver Failure, Acute; L

1996
A fatal trip with ecstasy: a case of 3,4-methylenedioxymethamphetamine/3,4- methylenedioxyamphetamine toxicity.
    Journal of the Royal Society of Medicine, 1996, Volume: 89, Issue:1

    Topics: Adolescent; Fatal Outcome; Female; Fever; Humans; N-Methyl-3,4-methylenedioxyamphetamine; Physical E

1996
Studies on the mechanism of p-chloroamphetamine neurotoxicity.
    Biochemical pharmacology, 1996, Oct-25, Volume: 52, Issue:8

    Topics: Animals; Brain; Clorgyline; Dopamine; Fever; Hydroxyindoleacetic Acid; Indans; Male; Monoamine Oxida

1996
3,4-methylenedioxymethamphetamine (MDMA, or "ecstasy") and associated hypoglycemia.
    The American journal of emergency medicine, 1997, Volume: 15, Issue:2

    Topics: Acute Disease; Adult; Dantrolene; Female; Fever; Hallucinogens; Humans; Hypoglycemia; Muscle Relaxan

1997
Accidental ingestion of Ecstasy by a toddler: unusual cause for convulsion in a febrile child.
    Journal of accident & emergency medicine, 1997, Volume: 14, Issue:3

    Topics: Akathisia, Drug-Induced; Child, Preschool; Deglutition; Diagnosis, Differential; Female; Fever; Hall

1997
Ecstasy, serotonin syndrome and the treatment of hyperpyrexia.
    The Medical journal of Australia, 1997, Jul-21, Volume: 167, Issue:2

    Topics: Drug Overdose; Fever; Humans; Mental Disorders; N-Methyl-3,4-methylenedioxyamphetamine; Serotonin; S

1997
MDMA induced hyperthermia: a survivor with an initial body temperature of 42.9 degrees C.
    Journal of accident & emergency medicine, 1997, Volume: 14, Issue:5

    Topics: Adult; Blood Gas Analysis; Body Temperature; Dantrolene; Emergency Service, Hospital; Fever; Halluci

1997
Ecstasy: creatinine kinase.
    Anaesthesia and intensive care, 1997, Volume: 25, Issue:5

    Topics: 3,4-Methylenedioxyamphetamine; Creatine Kinase; Dantrolene; Designer Drugs; Fever; Humans; Multiple

1997
Small changes in ambient temperature cause large changes in 3,4-methylenedioxymethamphetamine (MDMA)-induced serotonin neurotoxicity and core body temperature in the rat.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998, Jul-01, Volume: 18, Issue:13

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Body Temperature; Body Temperature Regulation; Brain Chemis

1998
Role of hyperthermia in the protective action of clomethiazole against MDMA ('ecstasy')-induced neurodegeneration, comparison with the novel NMDA channel blocker AR-R15896AR.
    British journal of pharmacology, 1998, Volume: 124, Issue:3

    Topics: Animals; Body Temperature; Brain Chemistry; Chlormethiazole; Excitatory Amino Acid Antagonists; Feve

1998
Death by "ecstasy": the serotonin syndrome?
    Annals of emergency medicine, 1998, Volume: 32, Issue:3 Pt 1

    Topics: Adult; Arrhythmias, Cardiac; Autonomic Nervous System Diseases; Cognition Disorders; Epilepsy, Tonic

1998
Amphetamine derivative fatalities in South Australia--is "Ecstasy" the culprit?
    The American journal of forensic medicine and pathology, 1998, Volume: 19, Issue:3

    Topics: Adult; Australia; Central Nervous System Stimulants; Cerebral Hemorrhage; Drug Overdose; Fatal Outco

1998
Fatal multi-organ failure after suicidal overdose with MDMA, 'ecstasy': case report and review of the literature.
    Human & experimental toxicology, 1999, Volume: 18, Issue:2

    Topics: Disseminated Intravascular Coagulation; Fatal Outcome; Fever; Humans; Male; Middle Aged; N-Methyl-3,

1999
The acute effect in rats of 3,4-methylenedioxyethamphetamine (MDEA, "eve") on body temperature and long term degeneration of 5-HT neurones in brain: a comparison with MDMA ("ecstasy").
    Pharmacology & toxicology, 1999, Volume: 84, Issue:6

    Topics: 3,4-Methylenedioxyamphetamine; Amphetamines; Animals; Brain; Cerebral Cortex; Dose-Response Relation

1999
Effects of antihistamines on 3, 4-methylenedioxymethamphetamine-induced depletion of serotonin in rats.
    Synapse (New York, N.Y.), 1999, Sep-01, Volume: 33, Issue:3

    Topics: Adrenergic Uptake Inhibitors; Animals; Body Temperature; Brain Chemistry; Chlorpheniramine; Fever; H

1999
Alpha-lipoic acid prevents 3,4-methylenedioxy-methamphetamine (MDMA)-induced neurotoxicity.
    Neuroreport, 1999, Nov-26, Volume: 10, Issue:17

    Topics: Animals; Antioxidants; Astrocytes; Binding Sites; Carrier Proteins; Fever; Frontal Lobe; Glial Fibri

1999
Bilateral gluteal compartment syndrome after 'ecstasy' hyperpyrexia.
    Journal of the Royal Society of Medicine, 2000, Volume: 93, Issue:5

    Topics: Adult; Buttocks; Compartment Syndromes; Fever; Hallucinogens; Humans; Male; N-Methyl-3,4-methylenedi

2000
Ascorbic acid prevents 3,4-methylenedioxymethamphetamine (MDMA)-induced hydroxyl radical formation and the behavioral and neurochemical consequences of the depletion of brain 5-HT.
    Synapse (New York, N.Y.), 2001, Volume: 40, Issue:1

    Topics: Animals; Antioxidants; Ascorbic Acid; Behavior, Animal; Brain; Dopamine; Dose-Response Relationship,

2001
Is hyperthermia the triggering factor for hepatotoxicity induced by 3,4-methylenedioxymethamphetamine (ecstasy)? An in vitro study using freshly isolated mouse hepatocytes.
    Archives of toxicology, 2001, Volume: 74, Issue:12

    Topics: Animals; Cell Survival; Dose-Response Relationship, Drug; Fever; Glutathione; Hepatocytes; Hot Tempe

2001
Behavioural, hyperthermic and neurotoxic effects of 3,4-methylenedioxymethamphetamine analogues in the Wistar rat.
    Progress in neuro-psychopharmacology & biological psychiatry, 2001, Volume: 25, Issue:3

    Topics: 3,4-Methylenedioxyamphetamine; Animals; Biogenic Monoamines; Brain; Dopamine; Fever; Locomotion; Mal

2001
Cutaneous vasoconstriction contributes to hyperthermia induced by 3,4-methylenedioxymethamphetamine (ecstasy) in conscious rabbits.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001, Nov-01, Volume: 21, Issue:21

    Topics: Animals; Blood Flow Velocity; Blood Pressure; Body Temperature; Cold Temperature; Dose-Response Rela

2001
A study of the mechanisms involved in the neurotoxic action of 3,4-methylenedioxymethamphetamine (MDMA, 'ecstasy') on dopamine neurones in mouse brain.
    British journal of pharmacology, 2001, Volume: 134, Issue:8

    Topics: Animals; Chlormethiazole; Corpus Striatum; Cyclic N-Oxides; Dizocilpine Maleate; Dopamine; Dose-Resp

2001
The pharmacology of the acute hyperthermic response that follows administration of 3,4-methylenedioxymethamphetamine (MDMA, 'ecstasy') to rats.
    British journal of pharmacology, 2002, Volume: 135, Issue:1

    Topics: 3,4-Methylenedioxyamphetamine; Acute Disease; Animals; Benzazepines; Body Temperature; Corpus Striat

2002
3,4-Methylenedioxymethamphetamine produces glycogenolysis and increases the extracellular concentration of glucose in the rat brain.
    The Journal of pharmacology and experimental therapeutics, 2002, Volume: 301, Issue:1

    Topics: Animals; Body Temperature; Brain Chemistry; Corpus Striatum; Dose-Response Relationship, Drug; Extra

2002
Protection against 3,4-methylenedioxymethamphetamine-induced neurodegeneration produced by glutathione depletion in rats is mediated by attenuation of hyperthermia.
    Journal of neurochemistry, 2002, Volume: 81, Issue:4

    Topics: Animals; Brain; Brain Chemistry; Buthionine Sulfoximine; Drug Therapy, Combination; Fever; Glutathio

2002
Hyperpyrexia and rhabdomyolysis after MDMA ("ecstasy") abuse.
    Lancet (London, England), 1992, Mar-14, Volume: 339, Issue:8794

    Topics: 3,4-Methylenedioxyamphetamine; Adult; Fever; Humans; Male; N-Methyl-3,4-methylenedioxyamphetamine; R

1992
Ecstasy, 3-4 methylenedioxymethamphetamine (MDMA), a fatality associated with coagulopathy and hyperthermia.
    Journal of the Royal Society of Medicine, 1991, Volume: 84, Issue:6

    Topics: 3,4-Methylenedioxyamphetamine; Adolescent; Designer Drugs; Disseminated Intravascular Coagulation; F

1991
Multiple severe complications from recreational ingestion of MDMA ('Ecstasy')
    JAMA, 1987, Aug-14, Volume: 258, Issue:6

    Topics: 3,4-Methylenedioxyamphetamine; Adult; Amphetamines; Female; Fever; Hallucinations; Humans; N-Methyl-

1987