n-methyl-3,4-methylenedioxyamphetamine has been researched along with Fever in 171 studies
N-Methyl-3,4-methylenedioxyamphetamine: An N-substituted amphetamine analog. It is a widely abused drug classified as a hallucinogen and causes marked, long-lasting changes in brain serotonergic systems. It is commonly referred to as MDMA or ecstasy.
3,4-methylenedioxymethamphetamine : A member of the class of benzodioxoles that is 1,3-benzodioxole substituted by a 2-(methylamino)propyl group at position 5.
Fever: An abnormal elevation of body temperature, usually as a result of a pathologic process.
Excerpt | Relevance | Reference |
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"The use of dantrolene in the treatment of hyperpyrexia related to MDMA (3,4-methylenedioxymethamphetamine) is controversial, with little data available to guide clinical decision-making." | 8.86 | Dantrolene in the treatment of MDMA-related hyperpyrexia: a systematic review. ( Brubacher, JR; Grunau, BE; Wiens, MO, 2010) |
"We describe two cases of hyperthermia and rhabdomyolysis related to cocaine and/or ecstasy consumption." | 8.81 | [Rhabdomyolysis syndrome and hyperthermia secondary to cocaine and/or ecstasy consumption. Report of 2 new cases and review of the problem]. ( Arribas Castrillo, JM; García Diez, A; Suárez Arias, R; Vallina Alvarez, E, 2002) |
" The first case was due to a deadly intoxication by ecstasy and the second one to the deadly association of methadone and a possible neuroleptic malignant syndrome." | 4.98 | Postmortem Hyperthermia: Two Case Reports and a Review of the Literature. ( Franchi, A; Gambier, N; Gauchotte, G; Martrille, L; Raul, JS, 2018) |
"The use of dantrolene in the treatment of hyperpyrexia related to MDMA (3,4-methylenedioxymethamphetamine) is controversial, with little data available to guide clinical decision-making." | 4.86 | Dantrolene in the treatment of MDMA-related hyperpyrexia: a systematic review. ( Brubacher, JR; Grunau, BE; Wiens, MO, 2010) |
"We describe two cases of hyperthermia and rhabdomyolysis related to cocaine and/or ecstasy consumption." | 4.81 | [Rhabdomyolysis syndrome and hyperthermia secondary to cocaine and/or ecstasy consumption. Report of 2 new cases and review of the problem]. ( Arribas Castrillo, JM; García Diez, A; Suárez Arias, R; Vallina Alvarez, E, 2002) |
"Patients almost invariably present with convulsions accompanied by sympathetic signs and symptoms such as hyperthermia." | 2.49 | Ecstasy intoxication as an unusual cause of epileptic seizures in young children. ( Desmet, K; Eerdekens, K; Lemmens, F; Pauwels, S; Penders, J; Poesen, K; Vermeersch, P, 2013) |
" While it is known that their abuse could result in adverse health complications, including neurotoxicity, both the environmental conditions and activity states associated with their intake could strongly enhance drug toxicity, often resulting in life-threatening health complications." | 2.48 | Environmental conditions modulate neurotoxic effects of psychomotor stimulant drugs of abuse. ( Kiyatkin, EA; Sharma, HS, 2012) |
" Their abuse is associated with severe neurologic and psychiatric adverse events including the development of psychotic states." | 2.44 | Neurotoxicity of substituted amphetamines: molecular and cellular mechanisms. ( Cadet, JL; Jayanthi, S; Krasnova, IN; Lyles, J, 2007) |
" Clinically important toxic effects have been reported, including fatalities." | 2.43 | Acute toxic effects of 'Ecstasy' (MDMA) and related compounds: overview of pathophysiology and clinical management. ( Hall, AP; Henry, JA, 2006) |
"Adverse effects include hyperthermia, seizures, cardiac arrhythmias, hepatotoxicity, hyponatraemia and many psychiatric disorders." | 2.41 | Agony and ecstasy: a review of MDMA effects and toxicity. ( Burgess, C; Gill, M; O'Donohoe, A, 2000) |
"Clinically, the case highlights how physicians should be aware of the unusual time course adverse effects of ecstasy can have." | 1.56 | Protracted hyperthermia and delayed rhabdomyolysis in ecstasy toxicity: A case report. ( Eum, KS; Ghaffari-Rafi, A; Jahanmir, J; Villanueva, J, 2020) |
" Current studies focused on the effects of co- and/or postinhibition of VMAT2 on the acute and chronic effects of MDMA and on the dose-response relationship between MDMA-induced elevations in body temperature and subsequent reductions in indolamine concentrations." | 1.51 | Concurrent Inhibition of Vesicular Monoamine Transporter 2 Does Not Protect Against 3,4-Methylenedioxymethamphetamine (Ecstasy) Induced Neurotoxicity. ( Cholanians, AB; Lau, SS; Monks, TJ; Phan, AV, 2019) |
"Hyperpyrexia is a well-documented adverse effect of 3,4-methylenedioxymethamphetamine (MDMA) and is associated with a poor prognosis." | 1.48 | Too Hot to Handle: A Case Report of Extreme Pyrexia After MDMA Ingestion. ( Auzinger, G; Jahns, FP; Pineau Mitchell, A, 2018) |
" The present study aimed to evaluate the differential toxic effects of MDMA in adolescent and aged Wistar rats, using doses pharmacologically comparable to humans." | 1.48 | Aged rats are more vulnerable than adolescents to "ecstasy"-induced toxicity. ( Barbosa, DJ; Bastos, ML; Capela, JP; Carvalho, F; Costa, VM; Duarte, JA; Duarte-Araújo, M; Feio-Azevedo, R; Fernandes, E; Gomes, S; Marques, F; Pereira, FC; Pita, I; Teixeira-Gomes, A, 2018) |
"Carvedilol was modestly effective in attenuating MDMA-induced hyperthermia by moderately inhibiting skin vasoconstriction, and labetalol was ineffective." | 1.43 | Clinically Relevant Pharmacological Strategies That Reverse MDMA-Induced Brain Hyperthermia Potentiated by Social Interaction. ( Baumann, MH; Kiyatkin, EA; Ren, S; Shaham, Y; Wakabayashi, KT, 2016) |
" In conclusion, the study suggests a potentially dangerous effect of concomitant caffeine and mephedrone, and highlights the importance of taking polydrug use into consideration when investigating the acute adverse effect profile of popular recreational drugs." | 1.43 | Caffeine alters the behavioural and body temperature responses to mephedrone without causing long-term neurotoxicity in rats. ( Fone, KC; Green, AR; King, MV; Shortall, SE, 2016) |
" We showed that MDMA metabolites exhibited toxicity to SH-SY5Y differentiated cells, being the GSH and NAC conjugates more toxic than their catecholic precursors and MDMA." | 1.40 | "Ecstasy"-induced toxicity in SH-SY5Y differentiated cells: role of hyperthermia and metabolites. ( Barbosa, DJ; Bastos, ML; Branco, PS; Capela, JP; Carvalho, F; Fernandes, E; Ferreira, LM; Silva, R, 2014) |
"After achieving predefined malignant hyperthermia criteria, standardised therapy was initiated; dantrolene sodium suspension (5 mg kg(-1)) was administered and the injection was repeated after 24 min." | 1.39 | 3,4-Methylenedioxymethamphetamine induces a hyperthermic and hypermetabolic crisis in pigs with and without a genetic disposition for malignant hyperthermia. ( Becker, S; Gerbershagen, MU; Oldewurtel, C; Richard, A; Schäfer, U; Schütte, JK; Singler, P; Starosse, A; Wappler, F, 2013) |
"Mirtazapine is a novel antidepressant and a potent 5-HT(2A) receptor antagonist." | 1.37 | The effects of mirtazapine and fluoxetine on hyperthermia induced by 3,4-methylenedioxymethamphetamine (MDMA) in rats. ( Iwamura, T; Kasai, M; Kato, S; Nisijima, K; Shioda, K; Yoshino, T, 2011) |
"Treatment with prazosin (1mg/kg, i." | 1.36 | Role of serotonin and/or norepinephrine in the MDMA-induced increase in extracellular glucose and glycogenolysis in the rat brain. ( Bhide, N; Gudelsky, GA; Pachmerhiwala, R; Straiko, M, 2010) |
" Blood samples for analysis of glucose and lactate were taken at 30-45 min intervals before and after drug dosing and body temperature was monitored by telemetry." | 1.34 | Serotonin mediates rapid changes of striatal glucose and lactate metabolism after systemic 3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") administration in awake rats. ( Cumming, P; Gramsbergen, JB, 2007) |
"The purpose of the current study was to establish dose-response relationships for the effects of a number of commonly used illicit stimulants and investigate the behavioral response to increased core temperature." | 1.34 | Pharmacological and behavioral determinants of cocaine, methamphetamine, 3,4-methylenedioxymethamphetamine, and para-methoxyamphetamine-induced hyperthermia. ( Irvine, RJ; Jaehne, EJ; Salem, A, 2007) |
" These results extend our recent findings of additive toxic effects when METH is combined with MDMA." | 1.33 | MDMA ('Ecstasy') and methamphetamine combined: order of administration influences hyperthermic and long-term adverse effects in female rats. ( Clemens, KJ; Cornish, JL; Hunt, GE; Li, KM; McGregor, IS, 2005) |
"He presented with fever and seizures, tachycardia, hypertension, and hyperthermia." | 1.33 | Accidental ingestion of Ecstasy in a toddler. ( Chang, YJ; Chao, HC; Kong, MS; Lai, MW, 2005) |
" The acute effects stemming from this association, in tandem with the final potentiation of serotonergic terminals injury, provide evidence of the potentially greater long-term adverse effects of this particular recreational drug combination." | 1.33 | Association of caffeine to MDMA does not increase antinociception but potentiates adverse effects of this recreational drug. ( Camarasa, J; Escubedo, E; Pubill, D, 2006) |
"These results indicate that hyperthermia at the time of dosing with MDMA is not necessary to produce subsequent 5-HT depletion and anxiety in rats." | 1.32 | Increased anxiety and "depressive" symptoms months after MDMA ("ecstasy") in rats: drug-induced hyperthermia does not predict long-term outcomes. ( Blokland, A; Clemens, KJ; Cornish, JL; Gurtman, CG; Hunt, GE; Li, KM; McGregor, IS; Morley, KC, 2003) |
" "Poisoned ecstasy" was widely reported by the media as being responsible for the adverse effects observed." | 1.32 | Multiple toxicity from 3,4-methylenedioxymethamphetamine ("ecstasy"). ( Dargan, PI; Greene, SL; Jones, AL; Kerins, M; O'connor, N, 2003) |
"Nantenine functions as an effective antagonist against a wide range of MDMA-induced effects in mice." | 1.32 | Nantenine: an antagonist of the behavioral and physiological effects of MDMA in mice. ( Chen, X; Fantegrossi, WE; Karabenick, RL; Kiessel, CL; Leach, PT; Ohizumi, Y; Rice, KC; Ullrich, T; Van Martin, C; Woods, JH, 2004) |
"The consumption of 3,4-methylenedioxymethamphetamine (ecstasy; MDMA) may cause hepatocellular damage in humans, a toxic effect that has been increasing in frequency in the last few years, although the underlying mechanisms are still unknown." | 1.31 | Is hyperthermia the triggering factor for hepatotoxicity induced by 3,4-methylenedioxymethamphetamine (ecstasy)? An in vitro study using freshly isolated mouse hepatocytes. ( Bastos, ML; Carvalho, F; Carvalho, M, 2001) |
" After repeated dosing (8 x 20 mg/kg, i." | 1.31 | Behavioural, hyperthermic and neurotoxic effects of 3,4-methylenedioxymethamphetamine analogues in the Wistar rat. ( Boland, G; Kelly, JP; O'Boyle, KM; O'Loinsigh, ED, 2001) |
"He subsequently developed acute respiratory distress syndrome (ARDS), disseminated intravascular coagulopathy (DIC) and acute renal failure." | 1.30 | Fatal multi-organ failure after suicidal overdose with MDMA, 'ecstasy': case report and review of the literature. ( Seger, D; Walubo, A, 1999) |
"[3H]-paroxetine binding was also decreased by 27% in the cortex, indicating that the amine loss reflected a neurodegenerative change." | 1.29 | The hyperthermic and neurotoxic effects of 'Ecstasy' (MDMA) and 3,4 methylenedioxyamphetamine (MDA) in the Dark Agouti (DA) rat, a model of the CYP2D6 poor metabolizer phenotype. ( Colado, MI; Green, AR; Williams, JL, 1995) |
" At each Ta drinking water was freely available following dosing on one session and temporarily unavailable on a second." | 1.29 | Hyperthermia following MDMA administration in rats: effects of ambient temperature, water consumption, and chronic dosing. ( Dafters, RI, 1995) |
"Four patients presented with acute liver failure without hyperthermia." | 1.29 | Acute liver damage and ecstasy ingestion. ( Ellis, AJ; Portmann, B; Wendon, JA; Williams, R, 1996) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 1 (0.58) | 18.7374 |
1990's | 31 (18.13) | 18.2507 |
2000's | 90 (52.63) | 29.6817 |
2010's | 46 (26.90) | 24.3611 |
2020's | 3 (1.75) | 2.80 |
Authors | Studies |
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Stilmant, AC | 1 |
Zhu, L | 1 |
Gorur, Y | 1 |
Cardos, B | 1 |
Yerna, M | 1 |
Ali, D | 1 |
Lemoine, C | 1 |
Bréhin, C | 1 |
Micheau, P | 1 |
Lavit, M | 1 |
Claudet, I | 1 |
Ghaffari-Rafi, A | 1 |
Eum, KS | 1 |
Villanueva, J | 1 |
Jahanmir, J | 1 |
Haaland, A | 1 |
Warman, E | 1 |
Pushkar, I | 1 |
Likourezos, A | 1 |
Friedman, MS | 1 |
Jahns, FP | 1 |
Pineau Mitchell, A | 1 |
Auzinger, G | 1 |
Feio-Azevedo, R | 2 |
Costa, VM | 2 |
Barbosa, DJ | 2 |
Teixeira-Gomes, A | 2 |
Pita, I | 1 |
Gomes, S | 1 |
Pereira, FC | 1 |
Duarte-Araújo, M | 2 |
Duarte, JA | 5 |
Marques, F | 1 |
Fernandes, E | 7 |
Bastos, ML | 7 |
Carvalho, F | 10 |
Capela, JP | 4 |
Franchi, A | 1 |
Gauchotte, G | 1 |
Gambier, N | 1 |
Raul, JS | 1 |
Martrille, L | 1 |
Ridge, EA | 1 |
Pachhain, S | 1 |
Choudhury, SR | 1 |
Bodnar, SR | 1 |
Larsen, RA | 1 |
Phuntumart, V | 1 |
Sprague, JE | 12 |
Cholanians, AB | 2 |
Phan, AV | 2 |
Lau, SS | 2 |
Monks, TJ | 3 |
Musolino, ST | 1 |
Schartner, EP | 1 |
Hutchinson, MR | 1 |
Salem, A | 3 |
Pauwels, S | 1 |
Lemmens, F | 1 |
Eerdekens, K | 1 |
Penders, J | 1 |
Poesen, K | 1 |
Desmet, K | 1 |
Vermeersch, P | 1 |
Docherty, JR | 5 |
Bexis, S | 4 |
Silva, R | 2 |
Ferreira, LM | 3 |
Branco, PS | 3 |
Granado, N | 2 |
Ares-Santos, S | 1 |
Moratalla, R | 2 |
Pázmány, P | 1 |
Petschner, P | 1 |
Ádori, C | 1 |
Kirilly, E | 1 |
Andó, DR | 1 |
Balogh, B | 1 |
Gyöngyösi, N | 1 |
Bagdy, G | 1 |
Kiyatkin, EA | 5 |
Kim, AH | 1 |
Wakabayashi, KT | 2 |
Baumann, MH | 3 |
Shaham, Y | 2 |
Lizarraga, LE | 1 |
Herndon, JM | 1 |
Zaretsky, DV | 1 |
Zaretskaia, MV | 1 |
Durant, PJ | 1 |
Rusyniak, DE | 5 |
Ren, S | 1 |
Coman, D | 1 |
Sanganahalli, BG | 1 |
Jiang, L | 1 |
Hyder, F | 1 |
Behar, KL | 1 |
Shortall, SE | 1 |
Green, AR | 16 |
Fone, KC | 3 |
King, MV | 1 |
Bastos, Mde L | 1 |
Ren, SE | 1 |
Fonseca, DA | 1 |
Guerra, AF | 1 |
Antunes, PE | 1 |
Antunes, MJ | 1 |
Cotrim, MD | 1 |
Shioda, K | 3 |
Nisijima, K | 3 |
Yoshino, T | 3 |
Kuboshima, K | 2 |
Iwamura, T | 3 |
Yui, K | 1 |
Kato, S | 3 |
Pontes, H | 2 |
de Pinho, PG | 1 |
Soares, ME | 1 |
Dinis-Oliveira, RJ | 1 |
Sousa, C | 1 |
Carmo, H | 1 |
Casal, S | 1 |
Remião, F | 3 |
O'Shea, E | 10 |
Bove, J | 1 |
Vila, M | 1 |
Colado, MI | 12 |
Sharma, HS | 2 |
Ali, SF | 3 |
Alves, E | 1 |
Binienda, Z | 1 |
Alves, CJ | 1 |
de Lourdes Bastos, M | 1 |
Tavares, MA | 1 |
Summavielle, T | 1 |
Wyeth, RP | 1 |
Mills, EM | 8 |
Ullman, A | 1 |
Kenaston, MA | 1 |
Burwell, J | 1 |
Tóth, AR | 1 |
Varga, T | 1 |
Johnson, BN | 1 |
Yamamoto, BK | 5 |
Bhide, NS | 1 |
Lipton, JW | 1 |
Cunningham, JI | 1 |
Gudelsky, GA | 6 |
Orio, L | 4 |
Llopis, N | 1 |
Torres, E | 1 |
Izco, M | 2 |
Rodsiri, R | 2 |
Marsden, CA | 3 |
Piper, BJ | 1 |
Daniels, LG | 1 |
Meyer, JS | 2 |
Touriño, C | 1 |
Zimmer, A | 1 |
Valverde, O | 1 |
Jaehne, EJ | 2 |
Majumder, I | 1 |
Irvine, RJ | 3 |
Vanattou-Saïfoudine, N | 1 |
McNamara, R | 2 |
Harkin, A | 2 |
Pachmerhiwala, R | 1 |
Bhide, N | 1 |
Straiko, M | 1 |
Spicer, C | 1 |
Stanich, PP | 1 |
Mueller, PS | 1 |
Grunau, BE | 1 |
Wiens, MO | 1 |
Brubacher, JR | 1 |
Gilpin, NW | 1 |
Wright, MJ | 1 |
Dickinson, G | 1 |
Vandewater, SA | 1 |
Price, JU | 1 |
Taffe, MA | 3 |
Wallinga, AE | 1 |
Grahlmann, C | 1 |
Granneman, RA | 1 |
Koolhaas, JM | 1 |
Buwalda, B | 1 |
Kasai, M | 1 |
Shen, EY | 1 |
Hrometz, SL | 1 |
Thatcher, KE | 1 |
Ebert, JA | 1 |
Parrott, AC | 2 |
Papaseit, E | 1 |
Vázquez, A | 1 |
Pérez-Mañá, C | 1 |
Pujadas, M | 1 |
de la Torre, R | 2 |
Farré, M | 1 |
Nolla, J | 1 |
Muzzi, M | 1 |
Blasi, F | 1 |
Masi, A | 1 |
Coppi, E | 1 |
Traini, C | 1 |
Felici, R | 1 |
Pittelli, M | 1 |
Cavone, L | 1 |
Pugliese, AM | 1 |
Moroni, F | 1 |
Chiarugi, A | 1 |
Schütte, JK | 1 |
Schäfer, U | 1 |
Becker, S | 1 |
Oldewurtel, C | 1 |
Starosse, A | 1 |
Singler, P | 1 |
Richard, A | 1 |
Wappler, F | 1 |
Gerbershagen, MU | 1 |
Hare, BD | 1 |
D'Onfro, KC | 1 |
Hammack, SE | 1 |
Falls, WA | 1 |
Angoa-Pérez, M | 1 |
Kane, MJ | 1 |
Briggs, DI | 1 |
Francescutti, DM | 1 |
Sykes, CE | 1 |
Shah, MM | 1 |
Thomas, DM | 1 |
Kuhn, DM | 1 |
Gowing, LR | 1 |
Henry-Edwards, SM | 1 |
Ali, RL | 1 |
Núñez, O | 1 |
Bañares, R | 1 |
Barrio, J | 1 |
Menchén, L | 1 |
Diego, Ad | 1 |
Salinero, E | 1 |
Clemente, G | 1 |
Kanthasamy, A | 1 |
Shotwell, JR | 1 |
Nichols, DE | 2 |
Banks, ML | 2 |
Cook, VJ | 1 |
Blessing, WW | 4 |
Seaman, B | 2 |
Greene, SL | 1 |
Dargan, PI | 1 |
O'connor, N | 1 |
Jones, AL | 1 |
Kerins, M | 1 |
Pubill, D | 2 |
Canudas, AM | 1 |
Pallàs, M | 1 |
Camins, A | 1 |
Camarasa, J | 2 |
Escubedo, E | 2 |
McGregor, IS | 5 |
Gurtman, CG | 1 |
Morley, KC | 2 |
Clemens, KJ | 3 |
Blokland, A | 1 |
Li, KM | 4 |
Cornish, JL | 4 |
Hunt, GE | 5 |
Kunitz, O | 1 |
Ince, A | 1 |
Kuhlen, R | 1 |
Rossaint, R | 1 |
Pedersen, NP | 2 |
Ootsuka, Y | 1 |
Dafters, RI | 2 |
Biello, SM | 1 |
Dundes, L | 1 |
Finkel, T | 1 |
Saadat, KS | 2 |
Elliott, JM | 5 |
Beveridge, TJ | 1 |
Mechan, AO | 3 |
Sprakes, M | 1 |
Pei, Q | 1 |
Zetterstrom, TS | 1 |
Fantegrossi, WE | 1 |
Kiessel, CL | 1 |
Leach, PT | 1 |
Van Martin, C | 1 |
Karabenick, RL | 1 |
Chen, X | 1 |
Ohizumi, Y | 1 |
Ullrich, T | 2 |
Rice, KC | 2 |
Woods, JH | 1 |
Van Nieuwenhuyzen, PS | 1 |
Baucum, AJ | 1 |
Rau, KS | 1 |
Riddle, EL | 1 |
Hanson, GR | 1 |
Fleckenstein, AE | 1 |
Mallet, PE | 1 |
Brutcher, RE | 1 |
Caden, D | 2 |
Sanchez, V | 3 |
Pradillo, JM | 1 |
Escobedo, I | 2 |
Camarero, J | 2 |
Moro, MA | 1 |
Brown, PL | 1 |
Rosa-Neto, P | 1 |
Olsen, AK | 1 |
Gjedde, A | 1 |
Watanabe, H | 1 |
Cumming, P | 2 |
Gamma, A | 1 |
Melian, AM | 1 |
Burillo-Putze, G | 1 |
Campo, CG | 1 |
Padron, AG | 1 |
Ramos, CO | 1 |
Darvesh, AS | 2 |
Leão, A | 1 |
Magalhães, J | 1 |
Ascensão, A | 1 |
Amado, FL | 1 |
Vilarinho, L | 1 |
Quelhas, D | 1 |
Appell, HJ | 1 |
Salzmann, J | 1 |
Marie-Claire, C | 1 |
Noble, F | 1 |
Tandy, SL | 1 |
Hekmatyar, SK | 1 |
Mills, E | 1 |
Smith, DJ | 1 |
Bansal, N | 1 |
MacLellan, D | 1 |
Harper, ME | 1 |
Morton, J | 1 |
Herin, DV | 1 |
Liu, S | 1 |
Cunningham, KA | 1 |
Moze, P | 1 |
Holmes, C | 1 |
Goldstein, DS | 1 |
Jackson, WL | 1 |
Reveron, ME | 1 |
Duvauchelle, CL | 1 |
Meisel, A | 1 |
Abreu, AR | 1 |
Lobo, AM | 1 |
Kerans, A | 1 |
O'Neill, B | 1 |
Patel, MM | 1 |
Belson, MG | 1 |
Longwater, AB | 1 |
Olson, KR | 1 |
Miller, MA | 1 |
van Rijswijk, CW | 1 |
Kneyber, MC | 1 |
Plötz, FB | 1 |
Hall, AP | 2 |
Henry, JA | 2 |
Chang, YJ | 1 |
Lai, MW | 1 |
Kong, MS | 1 |
Chao, HC | 1 |
Von Huben, SN | 1 |
Lay, CC | 1 |
Crean, RD | 1 |
Davis, SA | 1 |
Katner, SN | 1 |
Hamida, SB | 1 |
Bach, S | 1 |
Plute, E | 1 |
Jones, BC | 3 |
Kelche, C | 1 |
Cassel, JC | 3 |
Hargreaves, GA | 1 |
Goñi-Allo, B | 2 |
Puerta, E | 2 |
Hervias, I | 1 |
Di Palma, R | 1 |
Ramos, M | 1 |
Lasheras, B | 3 |
Aguirre, N | 3 |
Cadet, JL | 2 |
Krasnova, IN | 1 |
Jayanthi, S | 1 |
Lyles, J | 1 |
Gramsbergen, JB | 1 |
Milani, RM | 1 |
Gouzoulis-Mayfrank, E | 1 |
Daumann, J | 1 |
Martin, TL | 1 |
Chiasson, DA | 1 |
Kish, SJ | 1 |
Weaver, KL | 1 |
Abramson, E | 1 |
Pfeiffer, M | 1 |
Moon, J | 1 |
Cros, J | 1 |
Ben Hamida, S | 1 |
Gordon, CJ | 1 |
Strobbe, L | 1 |
de Jaer, CP | 1 |
Louwerse, ES | 1 |
Rozendaal, FW | 1 |
O Mathúna, B | 1 |
Segura, M | 1 |
Clark, RD | 1 |
Franken, FH | 1 |
Rutter, JJ | 1 |
Rothman, RB | 1 |
Santos-Marques, MJ | 1 |
Williams, JL | 1 |
Cross, AJ | 1 |
Goodwin, GM | 1 |
Watson, JD | 1 |
Ferguson, C | 1 |
Hinds, CJ | 1 |
Skinner, R | 1 |
Coakley, JH | 1 |
Larner, AJ | 1 |
Webb, C | 1 |
Williams, V | 1 |
McCauley, JC | 1 |
Dowsett, RP | 1 |
Ellis, AJ | 1 |
Wendon, JA | 1 |
Portmann, B | 1 |
Williams, R | 1 |
Coore, JR | 1 |
Bodenham, AR | 2 |
Mallick, A | 2 |
White, SR | 1 |
Obradovic, T | 1 |
Imel, KM | 1 |
Wheaton, MJ | 1 |
Dar, KJ | 1 |
McBrien, ME | 1 |
Johnson, MP | 1 |
Schmidt, CJ | 1 |
Burnat, P | 1 |
Le Brumant-Payen, C | 1 |
Huart, B | 1 |
Ceppa, F | 1 |
Pailler, FM | 1 |
Montgomery, H | 1 |
Myerson, S | 1 |
Cooper, AJ | 1 |
Egleston, CV | 1 |
Gillman, PK | 1 |
Malberg, JE | 1 |
Seiden, LS | 1 |
Granados, R | 2 |
Esteban, B | 4 |
Mueller, PD | 1 |
Korey, WS | 1 |
Byard, RW | 1 |
Gilbert, J | 1 |
James, R | 1 |
Lokan, RJ | 1 |
Pennings, EJ | 1 |
Konijn, KZ | 1 |
de Wolff, FA | 1 |
Walubo, A | 1 |
Seger, D | 1 |
Yeh, SY | 1 |
Dersch, C | 1 |
Rothman, R | 1 |
Barrionuevo, M | 1 |
Ramírez, MJ | 1 |
Del Río, J | 1 |
Ferrie, R | 1 |
Loveland, RC | 1 |
Burgess, C | 1 |
O'Donohoe, A | 1 |
Gill, M | 1 |
Shankaran, M | 2 |
Carvalho, M | 1 |
O'Loinsigh, ED | 1 |
Boland, G | 1 |
Kelly, JP | 1 |
O'Boyle, KM | 1 |
Vallina Alvarez, E | 1 |
Suárez Arias, R | 1 |
García Diez, A | 1 |
Arribas Castrillo, JM | 1 |
Easton, N | 1 |
Fry, JR | 1 |
Screaton, GR | 1 |
Singer, M | 1 |
Cairns, HS | 1 |
Thrasher, A | 1 |
Sarner, M | 1 |
Cohen, SL | 1 |
Chadwick, IS | 1 |
Curry, PD | 1 |
Linsley, A | 1 |
Freemont, AJ | 1 |
Doran, B | 1 |
Brown, C | 1 |
Osterloh, J | 1 |
26 reviews available for n-methyl-3,4-methylenedioxyamphetamine and Fever
Article | Year |
---|---|
Postmortem Hyperthermia: Two Case Reports and a Review of the Literature.
Topics: Adult; Drug Overdose; Female; Fever; Humans; Male; Methadone; N-Methyl-3,4-methylenedioxyamphetamine | 2018 |
Ecstasy intoxication as an unusual cause of epileptic seizures in young children.
Topics: Female; Fever; Humans; Illicit Drugs; Infant; Male; N-Methyl-3,4-methylenedioxyamphetamine; Seizures | 2013 |
[The cognitive effects of ecstasy].
Topics: Cerebrovascular Circulation; Circadian Rhythm; Cognition; Cognition Disorders; Endocannabinoids; Fev | 2013 |
The role of monoamines in the changes in body temperature induced by 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) and its derivatives.
Topics: Animals; Biogenic Monoamines; Body Temperature; Dose-Response Relationship, Drug; Fever; Humans; Hyp | 2010 |
Dantrolene in the treatment of MDMA-related hyperpyrexia: a systematic review.
Topics: Clinical Trials as Topic; Dantrolene; Fever; Humans; Muscle Relaxants, Central; N-Methyl-3,4-methyle | 2010 |
MDMA and temperature: a review of the thermal effects of 'Ecstasy' in humans.
Topics: Body Temperature; Body Temperature Regulation; Dancing; Fever; Hallucinogens; Humans; N-Methyl-3,4-m | 2012 |
Environmental conditions modulate neurotoxic effects of psychomotor stimulant drugs of abuse.
Topics: Animals; Blood-Brain Barrier; Body Temperature; Brain; Brain Edema; Environment; Fever; Hot Temperat | 2012 |
The health effects of ecstasy: a literature review.
Topics: Animals; Fever; Humans; Illicit Drugs; N-Methyl-3,4-methylenedioxyamphetamine; Seizures; Substance-R | 2002 |
Neuropharmacology and neurotoxicity of 3,4-methylenedioxymethamphetamine.
Topics: Animals; Brain; Calcium; Dopamine; Fever; Free Radical Scavengers; N-Methyl-3,4-methylenedioxyamphet | 2003 |
The role of the sympathetic nervous system and uncoupling proteins in the thermogenesis induced by 3,4-methylenedioxymethamphetamine.
Topics: Animals; Body Temperature; Carrier Proteins; Fever; Hallucinogens; Humans; Ion Channels; Mitochondri | 2004 |
[Acute and long-term effects of ecstasy].
Topics: Animals; Brain Diseases; Chemical and Drug Induced Liver Injury; Fever; Hallucinogens; Humans; N-Met | 2004 |
Ecstasy: pharmacology and neurotoxicity.
Topics: Affect; Animals; Binding Sites; Brain; Fever; Hallucinogens; Humans; N-Methyl-3,4-methylenedioxyamph | 2005 |
Acute toxic effects of 'Ecstasy' (MDMA) and related compounds: overview of pathophysiology and clinical management.
Topics: Adolescent; Adult; Death, Sudden; Fever; Hallucinogens; Humans; Hyponatremia; Multiple Organ Failure | 2006 |
Neurotoxicity of substituted amphetamines: molecular and cellular mechanisms.
Topics: Amphetamines; Animals; Apoptosis; Central Nervous System Stimulants; Dopamine; Fever; Humans; Metham | 2007 |
Cannabis and Ecstasy/MDMA (3,4-methylenedioxymethamphetamine): an analysis of their neuropsychobiological interactions in recreational users.
Topics: Animals; Cannabis; Cytoprotection; Drug Interactions; Fever; Hallucinogens; Humans; Marijuana Abuse; | 2007 |
Thermophysiological responses to hyperthermic drugs: extrapolating from rodent to human.
Topics: Adrenergic Uptake Inhibitors; Animals; Body Temperature Regulation; Fever; Humans; N-Methyl-3,4-meth | 2007 |
Review of the pharmacology and clinical pharmacology of 3,4-methylenedioxymethamphetamine (MDMA or "Ecstasy").
Topics: Animals; Behavior, Animal; Fever; Humans; N-Methyl-3,4-methylenedioxyamphetamine; Serotonin; Tryptop | 1995 |
Exertional heat stroke induced by amphetamine analogues. Does dantrolene have a place?
Topics: 3,4-Methylenedioxyamphetamine; Adolescent; Adult; Blood Coagulation Disorders; Dancing; Dantrolene; | 1993 |
New dimensions in toxicology: hyperthermic syndrome following amphetamine derivatives.
Topics: Cause of Death; Diagnosis, Differential; Emergencies; Fever; Humans; N-Methyl-3,4-methylenedioxyamph | 1996 |
The effects of methylenedioxymethamphetamine (MDMA, "Ecstasy") on monoaminergic neurotransmission in the central nervous system.
Topics: Action Potentials; Animals; Brain; Brain Damage, Chronic; Dopamine; Fever; Guinea Pigs; Haplorhini; | 1996 |
MDMA induced hyperthermia: report of a fatality and review of current therapy.
Topics: Acute Kidney Injury; Adolescent; Blood Coagulation Disorders; Dantrolene; Fatal Outcome; Fever; Hall | 1996 |
[Ecstasy: psychostimulant, hallucinogen and toxic substance].
Topics: Animals; Central Nervous System; Fever; Hallucinogens; Humans; N-Methyl-3,4-methylenedioxyamphetamin | 1996 |
[Clinical and toxicologic aspects of the use of Ecstasy].
Topics: Animals; Axons; Brain Chemistry; Depression; Female; Fever; Humans; Impulsive Behavior; Inappropriat | 1998 |
Metabolic consequences of drug misuse.
Topics: Cocaine-Related Disorders; Delirium; Fever; Heroin Dependence; Humans; Hyponatremia; N-Methyl-3,4-me | 2000 |
Agony and ecstasy: a review of MDMA effects and toxicity.
Topics: Acute Disease; Animals; Arrhythmias, Cardiac; Chronic Disease; Fever; Hallucinogens; Humans; Hyponat | 2000 |
[Rhabdomyolysis syndrome and hyperthermia secondary to cocaine and/or ecstasy consumption. Report of 2 new cases and review of the problem].
Topics: Adult; Cocaine; Fever; Humans; Male; N-Methyl-3,4-methylenedioxyamphetamine; Rhabdomyolysis; Syndrom | 2002 |
145 other studies available for n-methyl-3,4-methylenedioxyamphetamine and Fever
Article | Year |
---|---|
[Fatal serotonin syndrome induced by ecstasy consumption].
Topics: Adult; Emergency Service, Hospital; Fever; Humans; Male; N-Methyl-3,4-methylenedioxyamphetamine; Ser | 2022 |
An unusual route of non-intentional intoxication by ecstasy in a toddler.
Topics: Child; Child, Preschool; Female; Fever; Humans; Hypertension; Mydriasis; N-Methyl-3,4-methylenedioxy | 2023 |
Protracted hyperthermia and delayed rhabdomyolysis in ecstasy toxicity: A case report.
Topics: Drug Overdose; Fever; Fluid Therapy; Humans; Male; N-Methyl-3,4-methylenedioxyamphetamine; Rhabdomyo | 2020 |
Isolated non-cardiogenic pulmonary edema - A rare complication of MDMA toxicity.
Topics: Fever; Holidays; Humans; Intubation, Intratracheal; Male; N-Methyl-3,4-methylenedioxyamphetamine; Pu | 2017 |
Too Hot to Handle: A Case Report of Extreme Pyrexia After MDMA Ingestion.
Topics: Adolescent; Fever; Hallucinogens; Humans; Hypothermia, Induced; Male; N-Methyl-3,4-methylenedioxyamp | 2018 |
Aged rats are more vulnerable than adolescents to "ecstasy"-induced toxicity.
Topics: Aging; Animals; Brain; Dopamine; Fever; Heart; Liver; Male; N-Methyl-3,4-methylenedioxyamphetamine; | 2018 |
The influence of the host microbiome on 3,4-methylenedioxymethamphetamine (MDMA)-induced hyperthermia and vice versa.
Topics: Animals; Fever; Hyperthermia, Induced; Male; Microbiota; N-Methyl-3,4-methylenedioxyamphetamine; Pro | 2019 |
Concurrent Inhibition of Vesicular Monoamine Transporter 2 Does Not Protect Against 3,4-Methylenedioxymethamphetamine (Ecstasy) Induced Neurotoxicity.
Topics: 2H-Benzo(a)quinolizin-2-ol, 2-Ethyl-1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy-; Animals; Bod | 2019 |
Minocycline attenuates 3,4-methylenedioxymethamphetamine-induced hyperthermia in the rat brain.
Topics: Animals; Body Temperature; Brain; Fever; Heart Rate; Locomotion; Male; Minocycline; N-Methyl-3,4-met | 2019 |
Influence of ketanserin on the effects of methylenedioxymethamphetamine on body temperature in the mouse.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic Uptake Inhibitors; Animals; Aorta; Body Temperat | 2013 |
"Ecstasy"-induced toxicity in SH-SY5Y differentiated cells: role of hyperthermia and metabolites.
Topics: 3,4-Methylenedioxyamphetamine; Acetylcysteine; Caspase 3; Cell Death; Cell Differentiation; Cell Lin | 2014 |
D1 but not D4 dopamine receptors are critical for MDMA-induced neurotoxicity in mice.
Topics: Animals; Corpus Striatum; Dopamine; Female; Fever; Male; Mice; Mice, Knockout; N-Methyl-3,4-methylen | 2014 |
Critical role of peripheral vasoconstriction in fatal brain hyperthermia induced by MDMA (Ecstasy) under conditions that mimic human drug use.
Topics: Animals; Body Temperature; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Fever; H | 2014 |
Vesicular monoamine transporter 2 and the acute and long-term response to 3,4-(±)-methylenedioxymethamphetamine.
Topics: 2H-Benzo(a)quinolizin-2-ol, 2-Ethyl-1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy-; Animals; Beh | 2015 |
Treadmill running restores MDMA-mediated hyperthermia prevented by inhibition of the dorsomedial hypothalamus.
Topics: Analysis of Variance; Animals; Body Temperature; Exercise Test; Fever; GABA-A Receptor Agonists; Hal | 2015 |
Clinically Relevant Pharmacological Strategies That Reverse MDMA-Induced Brain Hyperthermia Potentiated by Social Interaction.
Topics: Animals; Antipsychotic Agents; Body Temperature; Brain; Carbazoles; Carvedilol; Clozapine; Fever; Ha | 2016 |
Distribution of temperature changes and neurovascular coupling in rat brain following 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") exposure.
Topics: Anesthesia, General; Animals; Body Temperature; Brain; Cerebral Cortex; Fever; Magnetic Resonance Sp | 2015 |
Caffeine alters the behavioural and body temperature responses to mephedrone without causing long-term neurotoxicity in rats.
Topics: Animals; Behavior, Animal; Body Temperature; Brain; Caffeine; Discrimination, Psychological; Dopamin | 2016 |
"Ecstasy" toxicity to adolescent rats following an acute low binge dose.
Topics: Adenosine Triphosphate; Age Factors; Animals; Brain; Dose-Response Relationship, Drug; Fever; Halluc | 2016 |
MDMA, Methylone, and MDPV: Drug-Induced Brain Hyperthermia and Its Modulation by Activity State and Environment.
Topics: Animals; Antipsychotic Agents; Benzodioxoles; Body Temperature; Brain; Carbazoles; Carvedilol; Centr | 2017 |
Hyperthermia Severely Affects the Vascular Effects of MDMA and Metabolites in the Human Internal Mammary Artery In Vitro.
Topics: Adult; Aged; Aged, 80 and over; Dose-Response Relationship, Drug; Female; Fever; Humans; Male; Mamma | 2017 |
Risperidone attenuates and reverses hyperthermia induced by 3,4-methylenedioxymethamphetamine (MDMA) in rats.
Topics: Analysis of Variance; Animals; Body Temperature; Disease Models, Animal; Dopamine; Dopamine Antagoni | 2008 |
Chronic exposure to ethanol exacerbates MDMA-induced hyperthermia and exposes liver to severe MDMA-induced toxicity in CD1 mice.
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Body Temperature; Central | 2008 |
Persistent MDMA-induced dopaminergic neurotoxicity in the striatum and substantia nigra of mice.
Topics: Animals; Cell Death; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dose-Re | 2008 |
Acute administration of 3,4-methylenedioxymethamphetamine induces profound hyperthermia, blood-brain barrier disruption, brain edema formation, and cell injury.
Topics: Albumins; Animals; Astrocytes; Behavior, Animal; Blood-Brain Barrier; Body Temperature; Brain Edema; | 2008 |
Acetyl-L-carnitine provides effective in vivo neuroprotection over 3,4-methylenedioximethamphetamine-induced mitochondrial neurotoxicity in the adolescent rat brain.
Topics: Acetylcarnitine; Animals; Body Weight; Brain; Cyclooxygenase 1; DNA, Mitochondrial; Fever; Hallucino | 2009 |
The hyperthermia mediated by 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy) is sensitive to sex differences.
Topics: Adrenergic alpha-1 Receptor Agonists; Animals; Aorta; Female; Fever; Gene Expression Regulation; Hal | 2009 |
Myocardium and striated muscle damage caused by licit or illicit drugs.
Topics: Adolescent; Adult; Alprazolam; Anticonvulsants; Brain Edema; Clonazepam; Creatine Kinase; Female; Fe | 2009 |
Chronic unpredictable stress augments +3,4-methylenedioxymethamphetamine-induced monoamine depletions: the role of corticosterone.
Topics: Animals; Body Temperature; Brain; Corpus Striatum; Corticosterone; Dopamine; Enzyme Inhibitors; Feve | 2009 |
Role of alpha 1- and beta 3-adrenoceptors in the modulation by SR59230A of the effects of MDMA on body temperature in the mouse.
Topics: Adrenergic beta-3 Receptor Antagonists; Animals; Body Temperature; Fever; In Vitro Techniques; Male; | 2009 |
Repeated exposure to MDMA provides neuroprotection against subsequent MDMA-induced serotonin depletion in brain.
Topics: Adrenergic Uptake Inhibitors; Animals; Blotting, Western; Brain; Dopamine; Drug Tolerance; Fever; Me | 2009 |
A study on the mechanisms by which minocycline protects against MDMA ('ecstasy')-induced neurotoxicity of 5-HT cortical neurons.
Topics: Animals; Drug Administration Schedule; Fever; Frontal Lobe; Hypothalamus; Inflammation; Interleukin- | 2010 |
Effect of acute brain tyrosine depletion on MDMA-induced changes in brain 5-HT.
Topics: Animals; Corpus Striatum; Dopamine; Fever; Hippocampus; Male; N-Methyl-3,4-methylenedioxyamphetamine | 2010 |
Repeated intermittent methylenedioxymethamphetamine exposure protects against the behavioral and neurotoxic, but not hyperthermic, effects of an MDMA binge in adult rats.
Topics: Age Factors; Animals; Binding, Competitive; Body Temperature; Cerebral Cortex; Citalopram; Dose-Resp | 2010 |
THC Prevents MDMA Neurotoxicity in Mice.
Topics: Animals; Astrocytes; Body Temperature; Dronabinol; Fever; Hallucinogens; Indoles; Mice; Mice, Inbred | 2010 |
Increased effects of 3,4-methylenedioxymethamphetamine (ecstasy) in a rat model of depression.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Arousal; Body Temperature Regulation; Brain; Cerebral Corte | 2011 |
Mechanisms mediating the ability of caffeine to influence MDMA ('Ecstasy')-induced hyperthermia in rats.
Topics: Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Adrenergic alpha-Antagonists; | 2010 |
Role of serotonin and/or norepinephrine in the MDMA-induced increase in extracellular glucose and glycogenolysis in the rat brain.
Topics: Animals; Brain; Fever; Fluoxetine; Glucose; Glycogenolysis; Male; N-Methyl-3,4-methylenedioxyampheta | 2010 |
Acute concomitant effects of MDMA binge dosing on extracellular 5-HT, locomotion and body temperature and the long-term effect on novel object discrimination in rats.
Topics: Animals; Body Temperature; Discrimination Learning; Dose-Response Relationship, Drug; Drug Administr | 2011 |
21-year-old woman with palpitations and vomiting.
Topics: Diagnosis, Differential; Female; Fever; Humans; Illicit Drugs; N-Methyl-3,4-methylenedioxyamphetamin | 2010 |
Influences of activity wheel access on the body temperature response to MDMA and methamphetamine.
Topics: Animals; Behavior, Animal; Body Temperature; Dose-Response Relationship, Drug; Fever; Male; Methamph | 2011 |
Gender differences in hyperthermia and regional 5-HT and 5-HIAA depletion in the brain following MDMA administration in rats.
Topics: Animals; Brain; Disease Models, Animal; Female; Fever; Hydroxyindoleacetic Acid; Male; N-Methyl-3,4- | 2011 |
The effects of mirtazapine and fluoxetine on hyperthermia induced by 3,4-methylenedioxymethamphetamine (MDMA) in rats.
Topics: Animals; Antidepressive Agents, Tricyclic; Disease Models, Animal; Fever; Fluoxetine; Male; Mianseri | 2011 |
Chronic administration of THC prevents the behavioral effects of intermittent adolescent MDMA administration and attenuates MDMA-induced hyperthermia and neurotoxicity in rats.
Topics: Adrenergic Uptake Inhibitors; Age Factors; Analysis of Variance; Animals; Animals, Newborn; Behavior | 2011 |
Identification of a possible role for atrial natriuretic peptide in MDMA-induced hyperthermia.
Topics: Animals; Antipyretics; Atrial Natriuretic Factor; Body Temperature Regulation; Fever; Hallucinogens; | 2011 |
Δ9-Tetrahydrocannabinol attenuates MDMA-induced hyperthermia in rhesus monkeys.
Topics: Analgesics, Non-Narcotic; Analysis of Variance; Animals; Body Temperature; Cannabinoid Receptor Anta | 2012 |
Surviving life-threatening MDMA (3,4-methylenedioxymethamphetamine, ecstasy) toxicity caused by ritonavir (RTV).
Topics: Blood Component Transfusion; Contraindications; Drug Interactions; Fever; Fluid Therapy; Hallucinoge | 2012 |
Neurological basis of AMP-dependent thermoregulation and its relevance to central and peripheral hyperthermia.
Topics: 5'-Nucleotidase; Adenosine Monophosphate; Adrenergic Uptake Inhibitors; Animals; Body Temperature Re | 2013 |
3,4-Methylenedioxymethamphetamine induces a hyperthermic and hypermetabolic crisis in pigs with and without a genetic disposition for malignant hyperthermia.
Topics: Acidosis; Animals; Dantrolene; Fatty Acids, Nonesterified; Fever; Genetic Predisposition to Disease; | 2013 |
Memantine attenuates 3,4-methylenedioxymethamphetamine-induced hyperthermia in rats.
Topics: Animals; Brain Chemistry; Chromatography, High Pressure Liquid; Dopamine; Dopamine Agents; Fever; Ha | 2012 |
Prior stress interferes with the anxiolytic effect of exercise in C57BL/6J mice.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Fever; Male; Mice; Mice, Inbred C57BL; Motor Activity; N-Meth | 2012 |
Mephedrone does not damage dopamine nerve endings of the striatum, but enhances the neurotoxicity of methamphetamine, amphetamine, and MDMA.
Topics: Amphetamine; Animals; Corpus Striatum; Dopamine; Drug Synergism; Female; Fever; Methamphetamine; Mic | 2013 |
[Variability of the clinical expression of Ecstasy-induced hepatotoxicity].
Topics: Abdominal Pain; Adolescent; Adult; Biopsy; Chemical and Drug Induced Liver Injury; Cholestasis, Intr | 2002 |
Unilateral infusion of a dopamine transporter antisense into the substantia nigra protects against MDMA-induced serotonergic deficits in the ipsilateral striatum.
Topics: Animals; Carrier Proteins; Corpus Striatum; Dopamine Plasma Membrane Transport Proteins; Dopamine Up | 2002 |
Hypothalamic-pituitary-thyroid axis and sympathetic nervous system involvement in hyperthermia induced by 3,4-methylenedioxymethamphetamine (Ecstasy).
Topics: 3,4-Methylenedioxyamphetamine; Adrenergic alpha-Antagonists; Animals; Drug Interactions; Fever; Hypo | 2003 |
5-hydroxytryptamine(2A) receptors regulate sympathetic nerves constricting the cutaneous vascular bed in rabbits and rats.
Topics: Animals; Blood Pressure; Blood Vessels; Body Temperature; Dose-Response Relationship, Drug; Fever; H | 2003 |
Multiple toxicity from 3,4-methylenedioxymethamphetamine ("ecstasy").
Topics: Adolescent; Adult; Fatal Outcome; Female; Fever; Humans; Liver Failure; Male; N-Methyl-3,4-methylene | 2003 |
Different glial response to methamphetamine- and methylenedioxymethamphetamine-induced neurotoxicity.
Topics: Animals; Binding Sites; Body Weight; Brain; Carrier Proteins; Central Nervous System Diseases; Dopam | 2003 |
Increased anxiety and "depressive" symptoms months after MDMA ("ecstasy") in rats: drug-induced hyperthermia does not predict long-term outcomes.
Topics: Amygdala; Animals; Anxiety; Biogenic Monoamines; Cognition; Corpus Striatum; Depression; Fever; Hipp | 2003 |
[Hyperpyrexia and rhabdomyolysis after ecstasy (MDMA) intoxication].
Topics: Acute Kidney Injury; Adult; Disseminated Intravascular Coagulation; Diuresis; Fever; Hallucinogens; | 2003 |
Clozapine reverses hyperthermia and sympathetically mediated cutaneous vasoconstriction induced by 3,4-methylenedioxymethamphetamine (ecstasy) in rabbits and rats.
Topics: Anesthesia; Animals; Antipsychotic Agents; Benzodiazepines; Body Temperature; Clozapine; Disease Mod | 2003 |
The effect of 3,4-methylenedioxymethamphetamine ('Ecstasy') on serotonergic regulation of the mammalian circadian clock mechanism in rats: the role of dopamine and hyperthermia.
Topics: Animals; Body Temperature; Circadian Rhythm; Dopamine; Dopamine Antagonists; Fever; Male; N-Methyl-3 | 2003 |
DanceSafe and ecstasy: protection or promotion?
Topics: Adolescent; Adult; Fear; Female; Fever; Harm Reduction; Health Behavior; Humans; Male; N-Methyl-3,4- | 2003 |
Pharmacology: uncoupling the agony from ecstasy.
Topics: Animals; Body Temperature; Body Temperature Regulation; Carrier Proteins; Fever; Gene Deletion; Ion | 2003 |
New treatment for Ecstasy-related hyperthermia.
Topics: Animals; Antipsychotic Agents; Benzodiazepines; Clozapine; Disease Models, Animal; Fever; Humans; N- | 2003 |
Hyperthermic and neurotoxic effect of 3,4-methylenedioxymethamphetamine (MDMA) in guinea pigs.
Topics: Animals; Corpus Striatum; Dopamine; Dopamine Agents; Fever; Guinea Pigs; Male; N-Methyl-3,4-methylen | 2004 |
Effect of 5-HT depletion by MDMA on hyperthermia and Arc mRNA induction in rat brain.
Topics: Animals; Brain; Cytoskeletal Proteins; Fever; Immediate-Early Proteins; In Situ Hybridization; Male; | 2004 |
Nantenine: an antagonist of the behavioral and physiological effects of MDMA in mice.
Topics: Adrenergic alpha-Antagonists; Animals; Aporphines; Behavior, Animal; Crowding; Dose-Response Relatio | 2004 |
MDMA ("ecstasy"), methamphetamine and their combination: long-term changes in social interaction and neurochemistry in the rat.
Topics: Animals; Anxiety; Behavior, Animal; Body Temperature; Corpus Striatum; Dopamine; Dopamine Agents; Dr | 2004 |
Methamphetamine increases dopamine transporter higher molecular weight complex formation via a dopamine- and hyperthermia-associated mechanism.
Topics: Adrenergic Uptake Inhibitors; Amphetamine-Related Disorders; Animals; Blotting, Western; Dopamine; D | 2004 |
Cannabinoids prevent the acute hyperthermia and partially protect against the 5-HT depleting effects of MDMA ("Ecstasy") in rats.
Topics: Animals; Cannabinoids; Cyclohexanols; Fever; Male; Motor Activity; N-Methyl-3,4-methylenedioxyamphet | 2004 |
Attenuation of 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy)-induced rhabdomyolysis with alpha1- plus beta3-adrenoreceptor antagonists.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic beta-3 Receptor Antagonists; Animals; Blood Urea | 2004 |
3,4-Methylenedioxymethamphetamine increases interleukin-1beta levels and activates microglia in rat brain: studies on the relationship with acute hyperthermia and 5-HT depletion.
Topics: Acute Disease; Animals; Astrocytes; Binding, Competitive; Body Temperature; Brain; Cerebral Cortex; | 2004 |
Brain hyperthermia induced by MDMA (ecstasy): modulation by environmental conditions.
Topics: Animals; Body Temperature; Body Temperature Regulation; Brain; Environment; Female; Fever; Hallucino | 2004 |
MDMA-evoked changes in cerebral blood flow in living porcine brain: correlation with hyperthermia.
Topics: Animals; Brain; Cerebral Arteries; Cerebrovascular Circulation; Disease Models, Animal; Female; Feve | 2004 |
Keeping a clear head on effects of illicit drugs.
Topics: Bias; Clinical Trials, Phase I as Topic; Controlled Clinical Trials as Topic; Fever; Humans; Illicit | 2004 |
Accidental ecstasy poisoning in a toddler.
Topics: Accidents, Home; Benzodiazepines; Cardiac Complexes, Premature; Combined Modality Therapy; Fever; Hu | 2004 |
Evidence for the involvement of nitric oxide in 3,4-methylenedioxymethamphetamine-induced serotonin depletion in the rat brain.
Topics: Animals; Brain Chemistry; Citrulline; Dopamine; Enzyme Inhibitors; Fever; Male; Malonates; Microdial | 2005 |
Strenuous exercise aggravates MDMA-induced skeletal muscle damage in mice.
Topics: Animals; Body Temperature; Fever; Hallucinogens; Male; Mice; Microscopy, Electron, Transmission; Mot | 2005 |
The role of mitochondrial uncoupling in 3,4-methylenedioxymethamphetamine-mediated skeletal muscle hyperthermia and rhabdomyolysis.
Topics: Animals; Carrier Proteins; Dose-Response Relationship, Drug; Fever; Ion Channels; Male; Membrane Pro | 2005 |
The role of 5-HT in the impairment of thermoregulation observed in rats administered MDMA ('ecstasy') when housed at high ambient temperature.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Biogenic Monoamines; Body Temperature Regulation; B | 2005 |
Role of the serotonin 5-HT2A receptor in the hyperlocomotive and hyperthermic effects of (+)-3,4-methylenedioxymethamphetamine.
Topics: Animals; Dose-Response Relationship, Drug; Drug Antagonism; Drug Therapy, Combination; Fever; Fluoro | 2005 |
Carvedilol reverses hyperthermia and attenuates rhabdomyolysis induced by 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy) in an animal model.
Topics: Adrenergic beta-Antagonists; Analysis of Variance; Animals; Carbazoles; Carvedilol; Catecholamines; | 2005 |
Toward directed therapy for amphetamine-mediated hyperthermia: is carvedilol worth raving about?
Topics: Adrenergic beta-Antagonists; Amphetamines; Animals; Carbazoles; Carvedilol; Fever; Humans; N-Methyl- | 2005 |
MDMA ('Ecstasy') and methamphetamine combined: order of administration influences hyperthermic and long-term adverse effects in female rats.
Topics: Animals; Behavior, Animal; Body Temperature; Brain; Brain Chemistry; Central Nervous System Stimulan | 2005 |
Age-dependent (+)MDMA-mediated neurotoxicity in mice.
Topics: Aging; Animals; Body Temperature; Brain; Dopamine Plasma Membrane Transport Proteins; Fever; Halluci | 2005 |
Role of alpha2A-adrenoceptors in the effects of MDMA on body temperature in the mouse.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Animals; Body | 2005 |
3,4-Methylenedioxymethamphetamine increases pro-interleukin-1beta production and caspase-1 protease activity in frontal cortex, but not in hypothalamus, of Dark Agouti rats: role of interleukin-1beta in neurotoxicity.
Topics: Animals; Blotting, Western; Caspase 1; Chromatography, High Pressure Liquid; Fever; Frontal Lobe; Ha | 2005 |
Neurotoxicity of Ecstasy metabolites in rat cortical neurons, and influence of hyperthermia.
Topics: Acetylcysteine; Acridine Orange; Animals; Cell Death; Cells, Cultured; Cerebral Cortex; Culture Medi | 2006 |
Caffeine promotes hyperthermia and serotonergic loss following co-administration of the substituted amphetamines, MDMA ("Ecstasy") and MDA ("Love").
Topics: 3,4-Methylenedioxyamphetamine; Animals; Area Under Curve; Behavior, Animal; Body Temperature; Brain | 2006 |
Methylenedioxymethamphetamine (ecstasy)-related hyperthermia.
Topics: Adolescent; Adrenergic Uptake Inhibitors; Adult; Fatal Outcome; Female; Fever; Hallucinogens; Humans | 2005 |
Accidental ecstasy intoxication in an 8-month-old infant.
Topics: Drug Overdose; Fever; Humans; Hypertension; Infant; N-Methyl-3,4-methylenedioxyamphetamine; Netherla | 2006 |
Accidental ingestion of Ecstasy in a toddler.
Topics: Diagnosis, Differential; Fever; Humans; Hypertension; Infant; Male; N-Methyl-3,4-methylenedioxyamphe | 2005 |
Impact of ambient temperature on hyperthermia induced by (+/-)3,4-methylenedioxymethamphetamine in rhesus macaques.
Topics: Animals; Body Temperature; Body Temperature Regulation; Dose-Response Relationship, Drug; Drug Deliv | 2007 |
Ethanol-ecstasy (MDMA) interactions in rats: preserved attenuation of hyperthermia and potentiation of hyperactivity by ethanol despite prior ethanol treatment.
Topics: Animals; Body Temperature; Ethanol; Fever; Male; Motor Activity; N-Methyl-3,4-methylenedioxyamphetam | 2006 |
Association of caffeine to MDMA does not increase antinociception but potentiates adverse effects of this recreational drug.
Topics: Analgesics; Animals; Body Temperature; Brain; Caffeine; Central Nervous System Stimulants; Disease M | 2006 |
Binge ethanol administration enhances the MDMA-induced long-term 5-HT neurotoxicity in rat brain.
Topics: Acetaldehyde; Alcoholic Intoxication; Aldehyde Dehydrogenase; Animals; Body Temperature; Brain; Cent | 2007 |
Ethanol and MDMA: a comment on the paper by Izco et al.
Topics: Alcoholic Intoxication; Animals; Body Temperature; Brain; Central Nervous System Depressants; Drug S | 2007 |
High ambient temperature increases 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy")-induced Fos expression in a region-specific manner.
Topics: Adrenergic Uptake Inhibitors; Animals; Biomarkers; Body Temperature; Body Temperature Regulation; Br | 2007 |
Studies on the mechanisms underlying amiloride enhancement of 3,4-methylenedioxymethamphetamine-induced serotonin depletion in rats.
Topics: Amiloride; Animals; Body Temperature; Corpus Striatum; Drug Synergism; Fever; Hallucinogens; Male; N | 2007 |
Serotonin mediates rapid changes of striatal glucose and lactate metabolism after systemic 3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") administration in awake rats.
Topics: Animals; Body Temperature; Corpus Striatum; Dose-Response Relationship, Drug; Energy Metabolism; Ext | 2007 |
Does hyperthyroidism increase risk of death due to the ingestion of ecstasy?
Topics: Adult; Fatal Outcome; Female; Fever; Forensic Toxicology; Hallucinogens; Humans; Hyperthyroidism; N- | 2007 |
Pharmacological and behavioral determinants of cocaine, methamphetamine, 3,4-methylenedioxymethamphetamine, and para-methoxyamphetamine-induced hyperthermia.
Topics: Amphetamines; Animals; Behavior, Animal; Body Temperature Regulation; Central Nervous System Stimula | 2007 |
Influence of dietary fats on Ecstasy-induced hyperthermia.
Topics: Adipose Tissue, Brown; Analysis of Variance; Animals; Blotting, Western; Body Temperature; Diet, Fat | 2007 |
Role of dantrolene in the management of the acute toxic effects of Ecstasy (MDMA).
Topics: Acute Disease; Adult; Dantrolene; Fever; Hallucinogens; Humans; Male; Muscle Relaxants, Central; N-M | 2007 |
Attenuation of MDMA-induced hyperthermia by ethanol in rats depends on ambient temperature.
Topics: Analgesics, Non-Narcotic; Animals; Body Temperature; Disease Models, Animal; Ethanol; Fever; Male; N | 2007 |
[Fatal ecstasy intoxication in a 22-year-old man].
Topics: Adult; Fatal Outcome; Fever; Hallucinogens; Humans; Male; Multiple Organ Failure; N-Methyl-3,4-methy | 2007 |
Role of alpha1-adrenoceptor subtypes in the effects of methylenedioxy methamphetamine (MDMA) on body temperature in the mouse.
Topics: Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Animals; Body Temperature; Fever; Male; | 2008 |
The relationship between core body temperature and 3,4-methylenedioxymethamphetamine metabolism in rats: implications for neurotoxicity.
Topics: Animals; Body Temperature; Brain Chemistry; Catechol O-Methyltransferase; Catechol O-Methyltransfera | 2008 |
Tolerance to 3,4-methylenedioxymethamphetamine in rats exposed to single high-dose binges.
Topics: Animals; Body Temperature; Brain; Dopamine; Dose-Response Relationship, Drug; Down-Regulation; Drug | 2008 |
Effect of chronic ethanol exposure on the hepatotoxicity of ecstasy in mice: an ex vivo study.
Topics: Adenosine Triphosphate; Alcohol Drinking; Animals; Cell Survival; Collagen; Dose-Response Relationsh | 2008 |
The hyperthermic and neurotoxic effects of 'Ecstasy' (MDMA) and 3,4 methylenedioxyamphetamine (MDA) in the Dark Agouti (DA) rat, a model of the CYP2D6 poor metabolizer phenotype.
Topics: 3,4-Methylenedioxyamphetamine; Animals; Body Temperature Regulation; Brain; Cytochrome P-450 CYP2D6; | 1995 |
Dantrolene and 'ecstasy' overdose.
Topics: 3,4-Methylenedioxyamphetamine; Dantrolene; Designer Drugs; Fever; Humans; N-Methyl-3,4-methylenediox | 1993 |
Ecstasy intoxication: appreciation of complications and the role of dantrolene.
Topics: 3,4-Methylenedioxyamphetamine; Adult; Dantrolene; Designer Drugs; Fever; Humans; Male; N-Methyl-3,4- | 1993 |
Deaths attributed to an "ecstasy" overdose.
Topics: Dantrolene; Drug Overdose; Female; Fever; Hallucinogens; Humans; N-Methyl-3,4-methylenedioxyamphetam | 1996 |
Hyperthermia following MDMA administration in rats: effects of ambient temperature, water consumption, and chronic dosing.
Topics: Animals; Body Temperature; Drinking; Fever; Hyperkinesis; Male; Motor Activity; N-Methyl-3,4-methyle | 1995 |
Deaths attributed to "ecstasy" overdose.
Topics: Dantrolene; Drug Overdose; Fever; Hallucinogens; Humans; N-Methyl-3,4-methylenedioxyamphetamine | 1996 |
Acute liver damage and ecstasy ingestion.
Topics: Adolescent; Adult; Fatal Outcome; Female; Fever; Humans; Hypotension; Liver; Liver Failure, Acute; L | 1996 |
A fatal trip with ecstasy: a case of 3,4-methylenedioxymethamphetamine/3,4- methylenedioxyamphetamine toxicity.
Topics: Adolescent; Fatal Outcome; Female; Fever; Humans; N-Methyl-3,4-methylenedioxyamphetamine; Physical E | 1996 |
Studies on the mechanism of p-chloroamphetamine neurotoxicity.
Topics: Animals; Brain; Clorgyline; Dopamine; Fever; Hydroxyindoleacetic Acid; Indans; Male; Monoamine Oxida | 1996 |
3,4-methylenedioxymethamphetamine (MDMA, or "ecstasy") and associated hypoglycemia.
Topics: Acute Disease; Adult; Dantrolene; Female; Fever; Hallucinogens; Humans; Hypoglycemia; Muscle Relaxan | 1997 |
Accidental ingestion of Ecstasy by a toddler: unusual cause for convulsion in a febrile child.
Topics: Akathisia, Drug-Induced; Child, Preschool; Deglutition; Diagnosis, Differential; Female; Fever; Hall | 1997 |
Ecstasy, serotonin syndrome and the treatment of hyperpyrexia.
Topics: Drug Overdose; Fever; Humans; Mental Disorders; N-Methyl-3,4-methylenedioxyamphetamine; Serotonin; S | 1997 |
MDMA induced hyperthermia: a survivor with an initial body temperature of 42.9 degrees C.
Topics: Adult; Blood Gas Analysis; Body Temperature; Dantrolene; Emergency Service, Hospital; Fever; Halluci | 1997 |
Ecstasy: creatinine kinase.
Topics: 3,4-Methylenedioxyamphetamine; Creatine Kinase; Dantrolene; Designer Drugs; Fever; Humans; Multiple | 1997 |
Small changes in ambient temperature cause large changes in 3,4-methylenedioxymethamphetamine (MDMA)-induced serotonin neurotoxicity and core body temperature in the rat.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Body Temperature; Body Temperature Regulation; Brain Chemis | 1998 |
Role of hyperthermia in the protective action of clomethiazole against MDMA ('ecstasy')-induced neurodegeneration, comparison with the novel NMDA channel blocker AR-R15896AR.
Topics: Animals; Body Temperature; Brain Chemistry; Chlormethiazole; Excitatory Amino Acid Antagonists; Feve | 1998 |
Death by "ecstasy": the serotonin syndrome?
Topics: Adult; Arrhythmias, Cardiac; Autonomic Nervous System Diseases; Cognition Disorders; Epilepsy, Tonic | 1998 |
Amphetamine derivative fatalities in South Australia--is "Ecstasy" the culprit?
Topics: Adult; Australia; Central Nervous System Stimulants; Cerebral Hemorrhage; Drug Overdose; Fatal Outco | 1998 |
Fatal multi-organ failure after suicidal overdose with MDMA, 'ecstasy': case report and review of the literature.
Topics: Disseminated Intravascular Coagulation; Fatal Outcome; Fever; Humans; Male; Middle Aged; N-Methyl-3, | 1999 |
The acute effect in rats of 3,4-methylenedioxyethamphetamine (MDEA, "eve") on body temperature and long term degeneration of 5-HT neurones in brain: a comparison with MDMA ("ecstasy").
Topics: 3,4-Methylenedioxyamphetamine; Amphetamines; Animals; Brain; Cerebral Cortex; Dose-Response Relation | 1999 |
Effects of antihistamines on 3, 4-methylenedioxymethamphetamine-induced depletion of serotonin in rats.
Topics: Adrenergic Uptake Inhibitors; Animals; Body Temperature; Brain Chemistry; Chlorpheniramine; Fever; H | 1999 |
Alpha-lipoic acid prevents 3,4-methylenedioxy-methamphetamine (MDMA)-induced neurotoxicity.
Topics: Animals; Antioxidants; Astrocytes; Binding Sites; Carrier Proteins; Fever; Frontal Lobe; Glial Fibri | 1999 |
Bilateral gluteal compartment syndrome after 'ecstasy' hyperpyrexia.
Topics: Adult; Buttocks; Compartment Syndromes; Fever; Hallucinogens; Humans; Male; N-Methyl-3,4-methylenedi | 2000 |
Ascorbic acid prevents 3,4-methylenedioxymethamphetamine (MDMA)-induced hydroxyl radical formation and the behavioral and neurochemical consequences of the depletion of brain 5-HT.
Topics: Animals; Antioxidants; Ascorbic Acid; Behavior, Animal; Brain; Dopamine; Dose-Response Relationship, | 2001 |
Is hyperthermia the triggering factor for hepatotoxicity induced by 3,4-methylenedioxymethamphetamine (ecstasy)? An in vitro study using freshly isolated mouse hepatocytes.
Topics: Animals; Cell Survival; Dose-Response Relationship, Drug; Fever; Glutathione; Hepatocytes; Hot Tempe | 2001 |
Behavioural, hyperthermic and neurotoxic effects of 3,4-methylenedioxymethamphetamine analogues in the Wistar rat.
Topics: 3,4-Methylenedioxyamphetamine; Animals; Biogenic Monoamines; Brain; Dopamine; Fever; Locomotion; Mal | 2001 |
Cutaneous vasoconstriction contributes to hyperthermia induced by 3,4-methylenedioxymethamphetamine (ecstasy) in conscious rabbits.
Topics: Animals; Blood Flow Velocity; Blood Pressure; Body Temperature; Cold Temperature; Dose-Response Rela | 2001 |
A study of the mechanisms involved in the neurotoxic action of 3,4-methylenedioxymethamphetamine (MDMA, 'ecstasy') on dopamine neurones in mouse brain.
Topics: Animals; Chlormethiazole; Corpus Striatum; Cyclic N-Oxides; Dizocilpine Maleate; Dopamine; Dose-Resp | 2001 |
The pharmacology of the acute hyperthermic response that follows administration of 3,4-methylenedioxymethamphetamine (MDMA, 'ecstasy') to rats.
Topics: 3,4-Methylenedioxyamphetamine; Acute Disease; Animals; Benzazepines; Body Temperature; Corpus Striat | 2002 |
3,4-Methylenedioxymethamphetamine produces glycogenolysis and increases the extracellular concentration of glucose in the rat brain.
Topics: Animals; Body Temperature; Brain Chemistry; Corpus Striatum; Dose-Response Relationship, Drug; Extra | 2002 |
Protection against 3,4-methylenedioxymethamphetamine-induced neurodegeneration produced by glutathione depletion in rats is mediated by attenuation of hyperthermia.
Topics: Animals; Brain; Brain Chemistry; Buthionine Sulfoximine; Drug Therapy, Combination; Fever; Glutathio | 2002 |
Hyperpyrexia and rhabdomyolysis after MDMA ("ecstasy") abuse.
Topics: 3,4-Methylenedioxyamphetamine; Adult; Fever; Humans; Male; N-Methyl-3,4-methylenedioxyamphetamine; R | 1992 |
Ecstasy, 3-4 methylenedioxymethamphetamine (MDMA), a fatality associated with coagulopathy and hyperthermia.
Topics: 3,4-Methylenedioxyamphetamine; Adolescent; Designer Drugs; Disseminated Intravascular Coagulation; F | 1991 |
Multiple severe complications from recreational ingestion of MDMA ('Ecstasy')
Topics: 3,4-Methylenedioxyamphetamine; Adult; Amphetamines; Female; Fever; Hallucinations; Humans; N-Methyl- | 1987 |