n-methyl-3,4-methylenedioxyamphetamine has been researched along with Encephalopathy, Toxic in 144 studies
N-Methyl-3,4-methylenedioxyamphetamine: An N-substituted amphetamine analog. It is a widely abused drug classified as a hallucinogen and causes marked, long-lasting changes in brain serotonergic systems. It is commonly referred to as MDMA or ecstasy.
3,4-methylenedioxymethamphetamine : A member of the class of benzodioxoles that is 1,3-benzodioxole substituted by a 2-(methylamino)propyl group at position 5.
| Excerpt | Relevance | Reference |
|---|---|---|
| " One of such drugs is MDMA (3,4-methylenedioxymethamphetamine) or ecstasy due to its high consumption in relevant age and sex groups and its adverse effects on human and rodent developing brains." | 2.66 | Developmental neurotoxicity of MDMA. A systematic literature review summarized in a putative adverse outcome pathway. ( Barenys, M; Fritsche, E; Gómez-Catalán, J; Masjosthusmann, S; Reverte, I, 2020) |
| "3,4-Methylenedioxymethamphetamine (MDMA) induces both acute adverse effects and long-term neurotoxic loss of brain 5-HT neurones in laboratory animals." | 2.48 | Lost in translation: preclinical studies on 3,4-methylenedioxymethamphetamine provide information on mechanisms of action, but do not allow accurate prediction of adverse events in humans. ( Fone, KC; Green, AR; King, MV; Shortall, SE, 2012) |
| " Their abuse is associated with severe neurologic and psychiatric adverse events including the development of psychotic states." | 2.44 | Neurotoxicity of substituted amphetamines: molecular and cellular mechanisms. ( Cadet, JL; Jayanthi, S; Krasnova, IN; Lyles, J, 2007) |
| "This review of chronic tolerance to MDMA (3,4-methylenedioxymetamphetamine) covers the empirical data on dosage escalation, reduced subjective efficacy and bingeing in recreational Ecstasy users." | 2.43 | Chronic tolerance to recreational MDMA (3,4-methylenedioxymethamphetamine) or Ecstasy. ( Parrott, AC, 2005) |
| " A mistaken belief that it is a safe drug of low toxicity and a long duration of action has led to its widespread popularity among teenagers and young adults in recent years." | 2.43 | [Ecstasy toxicity]. ( Reingardiene, D, 2006) |
| " Although generally regarded as relatively safe, several studies have suggested a toxic effect on brain neurons in animals and possibly in humans." | 2.42 | [Plusridisciplinary approaches to understand the neutoxic effects of Ecstasy]. ( Noble, F; Roques, BP, 2003) |
| " These adverse events might be related to the neurotoxic effects of the drug." | 2.42 | Methylenedioxymethamphetamine (MDMA, Ecstasy) neurotoxicity: cellular and molecular mechanisms. ( Cadet, JL; Lyles, J, 2003) |
| " In the present paper, we review the extensive body of data demonstrating that MDMA produced toxic effects on brain 5-HT neurons in animals and present new data indicating that levels of the type 2 vesicular monoamine transporter are reduced in MDMA-treated animals, providing further indication of MDMA's 5-HT neurotoxic potential." | 2.41 | (+/-)3,4-Methylenedioxymethamphetamine ('Ecstasy')-induced serotonin neurotoxicity: studies in animals. ( McCann, UD; Ricaurte, GA; Yuan, J, 2000) |
| " There are many methodological problems and uncertainties with research in this field: non-random allocation of subjects to drug conditions, the deleterious effects of other psychoactive drugs, and the possibility that these adverse profiles reflect pre-existing personality characteristics in Ecstasy users." | 2.41 | Human research on MDMA (3,4-methylene- dioxymethamphetamine) neurotoxicity: cognitive and behavioural indices of change. ( Parrott, AC, 2000) |
| "The recreational use of MDMA (ecstasy) by pregnant women is associated with impaired neuromotor function in infants, but the Adverse Outcome Pathway behind this effect is not clear yet." | 1.72 | Developmental exposure to MDMA (ecstasy) in zebrafish embryos reproduces the neurotoxicity adverse outcome 'lower motor activity' described in humans. ( Álvarez, S; Barenys, M; Gómez-Catalán, J; Santamaria, A; Teixidó, E, 2022) |
| "Methylenedioxymethamphetamine (MDMA) and methcathinone (MCAT) are abused psychostimulant drugs that produce adverse effects in human users that include hepatotoxicity and death." | 1.56 | High ambient temperature increases the toxicity and lethality of 3,4-methylenedioxymethamphetamine and methcathinone. ( Chen, Y; Hall, FS; Saber, YH; Tran, HTN, 2020) |
| " Current studies focused on the effects of co- and/or postinhibition of VMAT2 on the acute and chronic effects of MDMA and on the dose-response relationship between MDMA-induced elevations in body temperature and subsequent reductions in indolamine concentrations." | 1.51 | Concurrent Inhibition of Vesicular Monoamine Transporter 2 Does Not Protect Against 3,4-Methylenedioxymethamphetamine (Ecstasy) Induced Neurotoxicity. ( Cholanians, AB; Lau, SS; Monks, TJ; Phan, AV, 2019) |
| " It is concluded that the two adverse events utilize distinctly different mediating molecules during the toxic initiation and intensification." | 1.51 | Differential role of dose and environment in initiating and intensifying neurotoxicity caused by MDMA in rats. ( Callanan, JJ; Ma, Z; Shields, CJ; Shokry, IM; Tao, R, 2019) |
| " However, its potential for adverse effects such as hyperthermia and neurotoxicity may limit its clinical viability." | 1.48 | Separating the agony from ecstasy: R(-)-3,4-methylenedioxymethamphetamine has prosocial and therapeutic-like effects without signs of neurotoxicity in mice. ( Curry, DW; Daoud, GE; Howell, LL; Tran, AN; Young, MB, 2018) |
| " The present study aimed to evaluate the differential toxic effects of MDMA in adolescent and aged Wistar rats, using doses pharmacologically comparable to humans." | 1.48 | Aged rats are more vulnerable than adolescents to "ecstasy"-induced toxicity. ( Barbosa, DJ; Bastos, ML; Capela, JP; Carvalho, F; Costa, VM; Duarte, JA; Duarte-Araújo, M; Feio-Azevedo, R; Fernandes, E; Gomes, S; Marques, F; Pereira, FC; Pita, I; Teixeira-Gomes, A, 2018) |
| " In conclusion, the study suggests a potentially dangerous effect of concomitant caffeine and mephedrone, and highlights the importance of taking polydrug use into consideration when investigating the acute adverse effect profile of popular recreational drugs." | 1.43 | Caffeine alters the behavioural and body temperature responses to mephedrone without causing long-term neurotoxicity in rats. ( Fone, KC; Green, AR; King, MV; Shortall, SE, 2016) |
| "Mephedrone is a stimulant drug of abuse with close structural and mechanistic similarities to methamphetamine and 3,4-methylenedioxymethamphetamine (MDMA)." | 1.40 | Effects of combined treatment with mephedrone and methamphetamine or 3,4-methylenedioxymethamphetamine on serotonin nerve endings of the hippocampus. ( Angoa-Pérez, M; Francescutti, DM; Herrera-Mundo, N; Kane, MJ; Kuhn, DM, 2014) |
| " We showed that MDMA metabolites exhibited toxicity to SH-SY5Y differentiated cells, being the GSH and NAC conjugates more toxic than their catecholic precursors and MDMA." | 1.40 | "Ecstasy"-induced toxicity in SH-SY5Y differentiated cells: role of hyperthermia and metabolites. ( Barbosa, DJ; Bastos, ML; Branco, PS; Capela, JP; Carvalho, F; Fernandes, E; Ferreira, LM; Silva, R, 2014) |
| " In conclusion, MDMA catechol metabolites promote differential toxic effects to differentiated dopaminergic human SH-SY5Y cells." | 1.39 | Neurotoxicity of "ecstasy" and its metabolites in human dopaminergic differentiated SH-SY5Y cells. ( Bastos, ML; Branco, PS; Capela, JP; Carvalho, F; Costa, VM; Fernandes, E; Ferreira, LM; Ferreira, PS; Meisel, A; Nogueira, TB, 2013) |
| " These associations suggest that chronic use of MDMA may lead to HPA axis dysregulation and that the magnitude of this may be moderated by genetic polymorphism, and warrant further investigation in a larger sample of those who consume the drug on a regular basis." | 1.38 | Pharmacogenetic studies of change in cortisol on ecstasy (MDMA) consumption. ( Aitchison, KJ; Forsling, ML; Kerwin, RW; Pariante, CM; Tsapakis, EM; Wolff, K, 2012) |
| " suggest that animal data could not be used to predict the adverse effects of 3,4-methylenedioxymethamphetamine (MDMA) in humans and that MDMA did not produce 5-HT neurotoxicity in the human brain." | 1.38 | MDMA and 5-HT neurotoxicity: the empirical evidence for its adverse effects in humans - no need for translation. ( Parrott, AC, 2012) |
| " This case report indicates that even non-chronic MDMA use may cause subacute toxic encephalopathy in which the clinical evolution is paralleled by neuroimaging changes in specific cerebral areas." | 1.35 | Hippocampal remodelling after MDMA neurotoxicity: a single case study. ( Amistà, P; Battaglia, M; Bertagnoni, GE; Carollo, C; Costanzo, R; Lupi, A; Martinuzzi, A; Nifosì, F; Perini, G; Toffanin, T; Vestri, A, 2009) |
| "Converging evidence was found for a specific toxic effect of ecstasy on serotonergic axons in the thalamus." | 1.35 | Neurotoxic effects of ecstasy on the thalamus. ( Booij, J; de Win, MM; Heeten, GJ; Jager, G; Lavini, C; Olabarriaga, SD; Ramsey, NF; Reneman, L; Schilt, T; van den Brink, W, 2008) |
| "Citalopram pretreatment blocked MDMA-related reductions in aggressive and exploratory behavior measured in the social interaction and hole-board tests respectively." | 1.35 | Dissociation of the neurochemical and behavioral toxicology of MDMA ('Ecstasy') by citalopram. ( Ali, SF; Fraiman, JB; Meyer, JS; Owens, CB; Piper, BJ, 2008) |
| " Acute hyperthermia, plasma tyrosine levels and concentrations of MDMA and its main metabolites were higher after a toxic (15 mg/kg i." | 1.35 | On the role of tyrosine and peripheral metabolism in 3,4-methylenedioxymethamphetamine-induced serotonin neurotoxicity in rats. ( Aguirre, N; de la Torre, R; Goñi-Allo, B; Hervias, I; Lasheras, B; Mathúna, BO; Puerta, E, 2008) |
| "3,4-Methylenedioxymethamphetamine (MDMA, designated as "Ecstasy" if illicitly marketed in tablet form) induces significant decrements in neuronal serotonin (5-HT) markers in humans, nonhuman primates, and rats as a function of dosing and dosing regimen." | 1.34 | MDMA (Ecstasy) and human dopamine, norepinephrine, and serotonin transporters: implications for MDMA-induced neurotoxicity and treatment. ( Madras, BK; Miller, GM; Verrico, CD, 2007) |
| ") 30 min before the same dosing of MDMA, and (4) treated with selegiline (2 mg/kg, i." | 1.34 | Monoamine oxidase-B mediates ecstasy-induced neurotoxic effects to adolescent rat brain mitochondria. ( Alves, CJ; Alves, E; Barata, JC; Bastos, Mde L; Carvalho, F; Fernandes, E; Gomes-da-Silva, J; Summavielle, T; Tavares, MA, 2007) |
| " Administration of MDMA leads to the formation of metabolites responsible for its toxic effects on serotonergic neurons in rats and non-human primates and on dopaminergic neurons in mice." | 1.31 | Involvement of free radicals in MDMA-induced neurotoxicity in mice. ( Cadet, JL; Jayanthi, S; Thiriet, N, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (0.69) | 18.2507 |
| 2000's | 77 (53.47) | 29.6817 |
| 2010's | 55 (38.19) | 24.3611 |
| 2020's | 11 (7.64) | 2.80 |
| Authors | Studies |
|---|---|
| Costa, G | 5 |
| Gołembiowska, K | 2 |
| Barenys, M | 2 |
| Álvarez, S | 1 |
| Santamaria, A | 1 |
| Teixidó, E | 1 |
| Gómez-Catalán, J | 2 |
| Eslami, SM | 1 |
| Khorshidi, L | 1 |
| Ghasemi, M | 1 |
| Rashidian, A | 1 |
| Mirghazanfari, M | 1 |
| Nezhadi, A | 1 |
| Chamanara, M | 1 |
| Mirjani, R | 1 |
| Bavato, F | 1 |
| Stamatakos, S | 1 |
| Ohki, CMY | 1 |
| Seifritz, E | 1 |
| Romualdi, P | 1 |
| Grünblatt, E | 1 |
| Quednow, BB | 1 |
| Serra, M | 1 |
| Maccioni, R | 1 |
| Casu, MA | 2 |
| Kasture, SB | 1 |
| Acquas, E | 1 |
| Morelli, M | 5 |
| Li, IH | 1 |
| Liu, TT | 1 |
| Chen, YC | 1 |
| Hsiao, SH | 1 |
| Hung, HY | 1 |
| Fann, LY | 1 |
| Shih, JH | 1 |
| Reverte, I | 1 |
| Masjosthusmann, S | 1 |
| Fritsche, E | 1 |
| Mead, J | 1 |
| Parrott, A | 2 |
| Chen, Y | 1 |
| Tran, HTN | 1 |
| Saber, YH | 1 |
| Hall, FS | 1 |
| Spulber, S | 1 |
| Paci, E | 1 |
| Ceccatelli, S | 1 |
| Simola, N | 4 |
| Abuin-Martínez, C | 1 |
| Vidal, R | 1 |
| Gutiérrez-López, MD | 2 |
| Pérez-Hernández, M | 1 |
| Giménez-Gómez, P | 1 |
| Morales-Puerto, N | 1 |
| O'Shea, E | 12 |
| Colado, MI | 13 |
| Curry, DW | 1 |
| Young, MB | 1 |
| Tran, AN | 1 |
| Daoud, GE | 1 |
| Howell, LL | 1 |
| Feio-Azevedo, R | 1 |
| Costa, VM | 3 |
| Barbosa, DJ | 4 |
| Teixeira-Gomes, A | 1 |
| Pita, I | 1 |
| Gomes, S | 1 |
| Pereira, FC | 1 |
| Duarte-Araújo, M | 1 |
| Duarte, JA | 1 |
| Marques, F | 1 |
| Fernandes, E | 8 |
| Bastos, ML | 4 |
| Carvalho, F | 9 |
| Capela, JP | 7 |
| Cholanians, AB | 4 |
| Phan, AV | 3 |
| Lau, SS | 6 |
| Monks, TJ | 6 |
| Shokry, IM | 1 |
| Shields, CJ | 1 |
| Callanan, JJ | 1 |
| Ma, Z | 1 |
| Tao, R | 1 |
| Parrott, AC | 9 |
| Peraile, I | 3 |
| Granado, N | 3 |
| Torres, E | 3 |
| Moratalla, R | 3 |
| Angoa-Pérez, M | 1 |
| Kane, MJ | 1 |
| Herrera-Mundo, N | 1 |
| Francescutti, DM | 1 |
| Kuhn, DM | 1 |
| Halpin, LE | 1 |
| Collins, SA | 1 |
| Yamamoto, BK | 2 |
| Soleimani Asl, S | 1 |
| Mousavizadeh, K | 1 |
| Mousavizedeh, K | 1 |
| Pourheydar, B | 1 |
| Soleimani, M | 1 |
| Rahbar, E | 1 |
| Mehdizadeh, M | 1 |
| Silva, R | 2 |
| Vilas-Boas, V | 1 |
| Ferreira, LM | 4 |
| Branco, PS | 4 |
| Bastos, Mde L | 3 |
| Herndon, JM | 3 |
| Serrat, R | 1 |
| Mirra, S | 1 |
| Quevedo, M | 1 |
| de Barreda, EG | 1 |
| Àvila, J | 1 |
| Lourdes Bastos, Md | 1 |
| Soriano, E | 1 |
| Lizarraga, LE | 2 |
| Górska, AM | 1 |
| Noworyta-Sokołowska, K | 1 |
| Ginat, DT | 1 |
| Garg, A | 1 |
| Kapoor, S | 1 |
| Goel, M | 1 |
| Chopra, S | 1 |
| Chopra, M | 1 |
| Kapoor, A | 1 |
| McCann, UD | 9 |
| Behera, C | 1 |
| Chiu, CH | 1 |
| Siow, TY | 1 |
| Weng, SJ | 1 |
| Hsu, YH | 1 |
| Huang, YS | 1 |
| Chang, KW | 1 |
| Cheng, CY | 1 |
| Ma, KH | 1 |
| Khairnar, A | 1 |
| García-Montes, JR | 1 |
| Porceddu, PF | 2 |
| Tizabi, Y | 1 |
| Shortall, SE | 2 |
| Green, AR | 7 |
| Fone, KC | 3 |
| King, MV | 2 |
| Frau, L | 1 |
| Vegting, Y | 1 |
| Reneman, L | 5 |
| Booij, J | 5 |
| Clark, L | 1 |
| Roiser, JP | 1 |
| Robbins, TW | 1 |
| Sahakian, BJ | 1 |
| Nifosì, F | 1 |
| Martinuzzi, A | 1 |
| Toffanin, T | 1 |
| Costanzo, R | 1 |
| Vestri, A | 1 |
| Battaglia, M | 1 |
| Bertagnoni, GE | 1 |
| Lupi, A | 1 |
| Amistà, P | 1 |
| Carollo, C | 1 |
| Perini, G | 1 |
| de Win, MM | 1 |
| Jager, G | 1 |
| Schilt, T | 1 |
| Lavini, C | 1 |
| Olabarriaga, SD | 1 |
| Ramsey, NF | 1 |
| Heeten, GJ | 1 |
| van den Brink, W | 2 |
| Cowan, RL | 2 |
| Joers, JM | 1 |
| Dietrich, MS | 1 |
| Alves, E | 2 |
| Summavielle, T | 2 |
| Alves, CJ | 2 |
| Custódio, JB | 1 |
| de Lourdes Bastos, M | 1 |
| Tavares, MA | 2 |
| Piper, BJ | 3 |
| Farelli, JD | 1 |
| Meyer, JS | 5 |
| Carmo, H | 1 |
| Remião, F | 1 |
| Meisel, A | 3 |
| Mueller, M | 4 |
| Kolbrich, EA | 1 |
| Peters, FT | 2 |
| Maurer, HH | 2 |
| Huestis, MA | 2 |
| Ricaurte, GA | 9 |
| Yuan, J | 4 |
| Felim, A | 1 |
| Neudörffer, A | 3 |
| Largeron, M | 3 |
| Orio, L | 3 |
| Llopis, N | 1 |
| Izco, M | 3 |
| Riezzo, I | 1 |
| Cerretani, D | 1 |
| Fiore, C | 1 |
| Bello, S | 1 |
| Centini, F | 1 |
| D'Errico, S | 1 |
| Fiaschi, AI | 1 |
| Giorgi, G | 1 |
| Neri, M | 1 |
| Pomara, C | 1 |
| Turillazzi, E | 1 |
| Fineschi, V | 1 |
| Escubedo, E | 4 |
| Camarasa, J | 4 |
| Chipana, C | 3 |
| García-Ratés, S | 1 |
| Pubill, D | 4 |
| Baumann, MH | 2 |
| Rothman, RB | 2 |
| Rodsiri, R | 1 |
| Marsden, CA | 1 |
| Biezonski, DK | 1 |
| Mayado, A | 1 |
| Lopez-Jimenez, A | 1 |
| Lopez-Moreno, JA | 1 |
| Touriño, C | 1 |
| Zimmer, A | 1 |
| Valverde, O | 4 |
| Puerta, E | 3 |
| Hervias, I | 2 |
| Goñi-Allo, B | 3 |
| Zhang, SF | 1 |
| Jordán, J | 1 |
| Starkov, AA | 1 |
| Aguirre, N | 3 |
| Johnson, BN | 1 |
| Abad, S | 1 |
| Torres, I | 2 |
| Adamaszek, M | 1 |
| Khaw, AV | 1 |
| Buck, U | 1 |
| Andresen, B | 1 |
| Thomasius, R | 1 |
| Ruiz-Medina, J | 3 |
| Ledent, C | 1 |
| Carretón, O | 1 |
| Ares-Santos, S | 1 |
| Oliva, I | 1 |
| Martin, ED | 1 |
| Lyvers, M | 2 |
| Martinez, CM | 1 |
| Mechan, A | 1 |
| McCann, U | 1 |
| Edwards, RR | 1 |
| Smith, MT | 1 |
| Kelley, K | 1 |
| Wilson, M | 1 |
| Sgambati, F | 1 |
| Ricaurte, G | 1 |
| Wallinga, AE | 1 |
| Grahlmann, C | 1 |
| Granneman, RA | 1 |
| Koolhaas, JM | 1 |
| Buwalda, B | 1 |
| Shen, EY | 1 |
| Ali, SF | 5 |
| Scheidweiler, KB | 1 |
| Ladenheim, B | 1 |
| Barnes, AJ | 1 |
| Cadet, JL | 4 |
| Wolff, K | 2 |
| Tsapakis, EM | 1 |
| Pariante, CM | 1 |
| Kerwin, RW | 1 |
| Forsling, ML | 1 |
| Aitchison, KJ | 1 |
| Ros-Simó, C | 1 |
| Schouw, ML | 1 |
| Gevers, S | 1 |
| Caan, MW | 1 |
| Majoie, CB | 1 |
| Nederveen, AJ | 1 |
| da Costa Araújo, S | 1 |
| Ruscher, K | 1 |
| Dirnagl, U | 1 |
| Benningfield, MM | 1 |
| Pinto-Xavier, A | 1 |
| Rodríguez-Arias, M | 1 |
| Miñarro, J | 1 |
| Ferreira, PS | 1 |
| Nogueira, TB | 1 |
| Maldonado-Adrian, C | 1 |
| Lock, J | 1 |
| Adnum, L | 1 |
| Thome, J | 1 |
| Aitchison, K | 1 |
| Habraken, JB | 1 |
| De Bruin, K | 1 |
| Hatzidimitriou, G | 2 |
| Den Heeten, GJ | 2 |
| Gamma, A | 1 |
| Itzhak, Y | 3 |
| Achat, CN | 1 |
| Anderson, KL | 2 |
| Sprague, JE | 2 |
| Banks, ML | 1 |
| Cook, VJ | 1 |
| Mills, EM | 1 |
| Boulu, R | 1 |
| Roques, BP | 1 |
| Noble, F | 1 |
| Gramond, JP | 1 |
| Fleury, MB | 1 |
| Lyles, J | 2 |
| Verbaten, MN | 1 |
| Cord, BJ | 1 |
| Domínguez Carmona, M | 1 |
| Rebato, AM | 1 |
| Sumnall, HR | 1 |
| Jerome, L | 1 |
| Doblin, R | 1 |
| Mithoefer, MC | 1 |
| Warburton, DM | 1 |
| Achat-Mendes, CN | 1 |
| Saadat, KS | 2 |
| Elliott, JM | 3 |
| Johnson, EA | 1 |
| O'Callaghan, JP | 1 |
| Miller, DB | 1 |
| Jones, DC | 2 |
| Bai, F | 2 |
| Gouzoulis-Meyfrank, E | 1 |
| Rodgers, J | 1 |
| Solowij, N | 1 |
| Nichols, DE | 1 |
| Achat-Mendes, C | 1 |
| Campbell, S | 1 |
| Qureshi, T | 1 |
| Sala, M | 1 |
| Braida, D | 1 |
| Verrico, CD | 1 |
| Miller, GM | 1 |
| Madras, BK | 1 |
| Schreckenberger, M | 1 |
| Vu, HL | 1 |
| Safain, MG | 1 |
| Oliver, AJ | 1 |
| Guillot, C | 1 |
| Li, SX | 1 |
| Li, J | 1 |
| Wang, X | 2 |
| Peng, ZG | 1 |
| Kuang, WH | 1 |
| Huang, MS | 1 |
| Fantegrossi, WE | 1 |
| Reingardiene, D | 1 |
| Jones, BC | 1 |
| Cassel, JC | 1 |
| Escobedo, I | 1 |
| Sessa, B | 1 |
| Krasnova, IN | 1 |
| Jayanthi, S | 2 |
| Fraiman, JB | 1 |
| Owens, CB | 1 |
| Gomes-da-Silva, J | 1 |
| Barata, JC | 1 |
| O Mathúna, B | 1 |
| Segura, M | 1 |
| Lasheras, B | 2 |
| de la Torre, R | 2 |
| Nakagawa, T | 1 |
| Kaneko, S | 1 |
| Mathúna, BO | 1 |
| Shankaran, M | 1 |
| Gudelsky, GA | 1 |
| Boot, BP | 1 |
| McGregor, IS | 1 |
| Hall, W | 1 |
| Eligulashvili, V | 1 |
| Schifano, F | 1 |
| Curran, HV | 1 |
| Turner, JJ | 1 |
| Kelly, PA | 1 |
| Russell, BR | 1 |
| Laverty, R | 1 |
| Thiriet, N | 1 |
| Mechan, AO | 1 |
| Lavalaye, J | 1 |
| Schmand, B | 1 |
| de Wolff, FA | 1 |
| Molliver, ME | 1 |
| Croft, RJ | 1 |
| Klugman, A | 1 |
| Baldeweg, T | 1 |
| Gruzelier, JH | 1 |
| Kalant, H | 1 |
35 reviews available for n-methyl-3,4-methylenedioxyamphetamine and Encephalopathy, Toxic
| Article | Year |
|---|---|
Neurotoxicity of MDMA: Main effects and mechanisms.
Topics: Animals; Brain; Hallucinogens; Humans; N-Methyl-3,4-methylenedioxyamphetamine; Neurotoxicity Syndrom | 2022 |
Developmental neurotoxicity of MDMA. A systematic literature review summarized in a putative adverse outcome pathway.
Topics: Adverse Outcome Pathways; Animals; Brain; Female; Humans; N-Methyl-3,4-methylenedioxyamphetamine; Ne | 2020 |
Mephedrone and MDMA: A comparative review.
Topics: Brain; Humans; Methamphetamine; N-Methyl-3,4-methylenedioxyamphetamine; Neurotoxicity Syndromes | 2020 |
MDMA, serotonergic neurotoxicity, and the diverse functional deficits of recreational 'Ecstasy' users.
Topics: Amphetamine-Related Disorders; Cognition; Cognition Disorders; Humans; Illicit Drugs; Memory; N-Meth | 2013 |
Neurotoxicity of methamphetamine and 3,4-methylenedioxymethamphetamine.
Topics: Animals; Central Nervous System Stimulants; Dopamine; Hallucinogens; Humans; Methamphetamine; Mitoch | 2014 |
Functional Magnetic Resonance Imaging in Abstinent MDMA Users: A Review.
Topics: Amphetamine-Related Disorders; Animals; Brain; Cognition; Cognition Disorders; Hallucinogens; Humans | 2015 |
Amphetamine-related drugs neurotoxicity in humans and in experimental animals: Main mechanisms.
Topics: Animals; Brain; Humans; Methamphetamine; N-Methyl-3,4-methylenedioxyamphetamine; Neurotoxicity Syndr | 2017 |
The effects of ecstasy on neurotransmitter systems: a review on the findings of molecular imaging studies.
Topics: Animals; Brain; Dopamine; Functional Neuroimaging; Hallucinogens; Humans; Magnetic Resonance Imaging | 2016 |
Molecular and cellular mechanisms of ecstasy-induced neurotoxicity: an overview.
Topics: Animals; Humans; N-Methyl-3,4-methylenedioxyamphetamine; Neurotoxicity Syndromes; Polymorphism, Gene | 2009 |
Involvement of nicotinic receptors in methamphetamine- and MDMA-induced neurotoxicity: pharmacological implications.
Topics: Animals; Brain; Central Nervous System Stimulants; Humans; Methamphetamine; N-Methyl-3,4-methylenedi | 2009 |
Lost in translation: preclinical studies on 3,4-methylenedioxymethamphetamine provide information on mechanisms of action, but do not allow accurate prediction of adverse events in humans.
Topics: Animals; Blood Proteins; Drug Evaluation, Preclinical; Hallucinogens; Humans; N-Methyl-3,4-methylene | 2012 |
Brain serotonin function in MDMA (ecstasy) users: evidence for persisting neurotoxicity.
Topics: Animals; Brain Chemistry; Humans; N-Methyl-3,4-methylenedioxyamphetamine; Neurotoxicity Syndromes; R | 2013 |
[Plusridisciplinary approaches to understand the neutoxic effects of Ecstasy].
Topics: Animals; Hallucinogens; Humans; N-Methyl-3,4-methylenedioxyamphetamine; Neurons; Neurotoxicity Syndr | 2003 |
[Biomimetic electrochemical synthesis of quinol-thioether conjugates: their implication in the serotonergic neurotoxicity of amphetamine derivatives].
Topics: Amphetamines; Animals; Biotransformation; Electrochemistry; Hallucinogens; Humans; Hydroquinones; Mo | 2003 |
Methylenedioxymethamphetamine (MDMA, Ecstasy) neurotoxicity: cellular and molecular mechanisms.
Topics: Animals; Brain; Embryonic and Fetal Development; Hallucinogens; Humans; Models, Animal; N-Methyl-3,4 | 2003 |
Specific memory deficits in ecstasy users? The results of a meta-analysis.
Topics: Attention; Hallucinogens; Humans; Memory Disorders; N-Methyl-3,4-methylenedioxyamphetamine; Neurotox | 2003 |
The role of metabolism in 3,4-(+)-methylenedioxyamphetamine and 3,4-(+)-methylenedioxymethamphetamine (ecstasy) toxicity.
Topics: 3,4-Methylenedioxyamphetamine; Animals; Blood-Brain Barrier; Catechols; Hallucinogens; Humans; Illic | 2004 |
A review of the mechanisms involved in the acute MDMA (ecstasy)-induced hyperthermic response.
Topics: Animals; Body Temperature; Cytokines; Dose-Response Relationship, Drug; Hallucinogens; Humans; Hypot | 2004 |
MDMA (3,4-Methylenedioxymethamphetamine) or ecstasy: the neuropsychobiological implications of taking it at dances and raves.
Topics: Animals; Dancing; Disease Models, Animal; Environment; Hallucinogens; Humans; Illicit Drugs; N-Methy | 2004 |
Chronic tolerance to recreational MDMA (3,4-methylenedioxymethamphetamine) or Ecstasy.
Topics: Drug Tolerance; Humans; N-Methyl-3,4-methylenedioxyamphetamine; Neurotoxicity Syndromes; Serotonin; | 2005 |
Endocannabinoids and 3,4-methylenedioxymethamphetamine (MDMA) interaction.
Topics: Animals; Cannabinoid Receptor Modulators; Cannabis; Drug Interactions; Endocannabinoids; Hallucinoge | 2005 |
A clinical crossroads for MDMA.
Topics: Animals; Hallucinogens; Humans; N-Methyl-3,4-methylenedioxyamphetamine; Neurotoxicity Syndromes; Ser | 2005 |
3,4-Methylenedioxymethamphetamine (MDMA) neurotoxicity in rats: a reappraisal of past and present findings.
Topics: Animals; Anxiety; Behavior, Animal; Biogenic Monoamines; Brain; Dopamine; Dose-Response Relationship | 2007 |
Reinforcing effects of methylenedioxy amphetamine congeners in rhesus monkeys: are intravenous self-administration experiments relevant to MDMA neurotoxicity?
Topics: Animals; Behavior, Animal; Biogenic Monoamines; Brain; Dose-Response Relationship, Drug; Hallucinoge | 2007 |
Recreational ecstasy use and the neurotoxic potential of MDMA: current status of the controversy and methodological issues.
Topics: Amphetamine-Related Disorders; Animals; Brain; Cognition Disorders; Diagnostic Imaging; Disease Mode | 2006 |
[Ecstasy toxicity].
Topics: Adolescent; Adult; Age Factors; Cardiovascular Diseases; Emergencies; Hallucinogens; Hospitalization | 2006 |
Neurotoxicity of substituted amphetamines: molecular and cellular mechanisms.
Topics: Amphetamines; Animals; Apoptosis; Central Nervous System Stimulants; Dopamine; Fever; Humans; Metham | 2007 |
Neuropsychotoxicity of abused drugs: molecular and neural mechanisms of neuropsychotoxicity induced by methamphetamine, 3,4-methylenedioxymethamphetamine (ecstasy), and 5-methoxy-N,N-diisopropyltryptamine (foxy).
Topics: 5-Methoxytryptamine; Animals; Brain; Central Nervous System Stimulants; Dopamine; Dopamine Plasma Me | 2008 |
(+/-)3,4-Methylenedioxymethamphetamine ('Ecstasy')-induced serotonin neurotoxicity: studies in animals.
Topics: Animals; N-Methyl-3,4-methylenedioxyamphetamine; Neurons; Neurotoxicity Syndromes; Serotonin Agents | 2000 |
(+/-)3,4-Methylenedioxymethamphetamine ('Ecstasy')-induced serotonin neurotoxicity: clinical studies.
Topics: Animals; Hallucinogens; Humans; N-Methyl-3,4-methylenedioxyamphetamine; Neurotoxicity Syndromes; Ser | 2000 |
Human research on MDMA (3,4-methylene- dioxymethamphetamine) neurotoxicity: cognitive and behavioural indices of change.
Topics: Behavior; Cognition; Hallucinogens; Humans; N-Methyl-3,4-methylenedioxyamphetamine; Neurotoxicity Sy | 2000 |
Potential human neurotoxicity of MDMA ('Ecstasy'): subjective self-reports, evidence from an Italian drug addiction centre and clinical case studies.
Topics: Hallucinogens; Humans; Italy; N-Methyl-3,4-methylenedioxyamphetamine; Neurotoxicity Syndromes; Serot | 2000 |
Is MDMA ('Ecstasy') neurotoxic in humans? An overview of evidence and of methodological problems in research.
Topics: Hallucinogens; Humans; N-Methyl-3,4-methylenedioxyamphetamine; Neurotoxicity Syndromes; Research; Se | 2000 |
The pharmacology and toxicology of "ecstasy" (MDMA) and related drugs.
Topics: Amphetamines; Brain; Cardiovascular System; Humans; Liver; Mental Disorders; N-Methyl-3,4-methylened | 2001 |
Recreational Ecstasy/MDMA, the serotonin syndrome, and serotonergic neurotoxicity.
Topics: Animals; Cognition Disorders; Humans; Memory Disorders; N-Methyl-3,4-methylenedioxyamphetamine; Neur | 2002 |
2 trials available for n-methyl-3,4-methylenedioxyamphetamine and Encephalopathy, Toxic
| Article | Year |
|---|---|
Disrupted 'reflection' impulsivity in cannabis users but not current or former ecstasy users.
Topics: Adult; Demography; Disruptive, Impulse Control, and Conduct Disorders; Female; Hallucinogens; Humans | 2009 |
Altered pain responses in abstinent (±)3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") users.
Topics: Adult; Brain; Female; Humans; Male; N-Methyl-3,4-methylenedioxyamphetamine; Neuropsychological Tests | 2011 |
107 other studies available for n-methyl-3,4-methylenedioxyamphetamine and Encephalopathy, Toxic
| Article | Year |
|---|---|
Developmental exposure to MDMA (ecstasy) in zebrafish embryos reproduces the neurotoxicity adverse outcome 'lower motor activity' described in humans.
Topics: Animals; Brain; Embryonic Development; Humans; Locomotion; N-Methyl-3,4-methylenedioxyamphetamine; N | 2022 |
Protective effects of atorvastatin and rosuvastatin on 3,4-methylenedioxymethamphetamine (MDMA)-induced spatial learning and memory impairment.
Topics: Animals; Apoptosis; Atorvastatin; Cognitive Dysfunction; Dose-Response Relationship, Drug; Hippocamp | 2021 |
Brain-derived neurotrophic factor protects serotonergic neurons against 3,4-methylenedioxymethamphetamine ("Ecstasy") induced cytoskeletal damage.
Topics: Animals; Brain; Brain-Derived Neurotrophic Factor; N-Methyl-3,4-methylenedioxyamphetamine; Neurotoxi | 2022 |
Withania somnifera influences MDMA-induced hyperthermic, cognitive, neurotoxic and neuroinflammatory effects in mice.
Topics: Animals; Cognition; Gliosis; Hyperthermia, Induced; Mice; N-Methyl-3,4-methylenedioxyamphetamine; Ne | 2023 |
Therapeutic effects of methimazole on 3,4-methylenedioxymethamphetamine-induced hyperthermia and serotonergic neurotoxicity.
Topics: Animals; Body Temperature; Hyperthermia, Induced; Male; Methimazole; N-Methyl-3,4-methylenedioxyamph | 2023 |
High ambient temperature increases the toxicity and lethality of 3,4-methylenedioxymethamphetamine and methcathinone.
Topics: Ammonia; Animals; Brain; Central Nervous System Stimulants; Disease Models, Animal; Female; Glutamic | 2020 |
In utero exposure to dexamethasone causes a persistent and age-dependent exacerbation of the neurotoxic effects and glia activation induced by MDMA in dopaminergic brain regions of C57BL/6J mice.
Topics: Age Factors; Animals; Brain; Calcium-Binding Proteins; Dexamethasone; Disease Models, Animal; Diseas | 2021 |
Increased kynurenine concentration attenuates serotonergic neurotoxicity induced by 3,4-methylenedioxymethamphetamine (MDMA) in rats through activation of aryl hydrocarbon receptor.
Topics: Animals; Autoradiography; Hippocampus; Kynurenine; N-Methyl-3,4-methylenedioxyamphetamine; Neurotoxi | 2021 |
Progression and Persistence of Neurotoxicity Induced by MDMA in Dopaminergic Regions of the Mouse Brain and Association with Noradrenergic, GABAergic, and Serotonergic Damage.
Topics: Adrenergic Neurons; Animals; Brain; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Pr | 2017 |
Separating the agony from ecstasy: R(-)-3,4-methylenedioxymethamphetamine has prosocial and therapeutic-like effects without signs of neurotoxicity in mice.
Topics: Animals; Body Temperature; Brain; Conditioning, Classical; Dopamine; Dopamine Plasma Membrane Transp | 2018 |
Aged rats are more vulnerable than adolescents to "ecstasy"-induced toxicity.
Topics: Aging; Animals; Brain; Dopamine; Fever; Heart; Liver; Male; N-Methyl-3,4-methylenedioxyamphetamine; | 2018 |
Concurrent Inhibition of Vesicular Monoamine Transporter 2 Does Not Protect Against 3,4-Methylenedioxymethamphetamine (Ecstasy) Induced Neurotoxicity.
Topics: 2H-Benzo(a)quinolizin-2-ol, 2-Ethyl-1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy-; Animals; Bod | 2019 |
Differential role of dose and environment in initiating and intensifying neurotoxicity caused by MDMA in rats.
Topics: Animals; Brain; Dose-Response Relationship, Drug; Environment; Male; N-Methyl-3,4-methylenedioxyamph | 2019 |
Cocaine potentiates MDMA-induced oxidative stress but not dopaminergic neurotoxicity in mice: implications for the pathogenesis of free radical-induced neurodegenerative disorders.
Topics: Animals; Cocaine; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Free Radic | 2013 |
Effects of combined treatment with mephedrone and methamphetamine or 3,4-methylenedioxymethamphetamine on serotonin nerve endings of the hippocampus.
Topics: Animals; Central Nervous System Stimulants; Chromatography, High Pressure Liquid; Designer Drugs; Fe | 2014 |
Protective effects of N-acetylcysteine on 3, 4-methylenedioxymethamphetamine-induced neurotoxicity in male Sprague-Dawley rats.
Topics: Acetylcysteine; Animals; bcl-2-Associated X Protein; Caspase 3; Cell Death; Down-Regulation; Hippoca | 2013 |
The mixture of "ecstasy" and its metabolites is toxic to human SH-SY5Y differentiated cells at in vivo relevant concentrations.
Topics: Acetylcysteine; Calcium; Caspase 3; Cell Differentiation; Cell Line; Deoxyepinephrine; Dopamine; Dop | 2014 |
"Ecstasy"-induced toxicity in SH-SY5Y differentiated cells: role of hyperthermia and metabolites.
Topics: 3,4-Methylenedioxyamphetamine; Acetylcysteine; Caspase 3; Cell Death; Cell Differentiation; Cell Lin | 2014 |
Glial cell response to 3,4-(+/-)-methylenedioxymethamphetamine and its metabolites.
Topics: 3,4-Methylenedioxyamphetamine; Animals; Astrocytes; Cell Proliferation; Cells, Cultured; Coculture T | 2014 |
The mixture of "ecstasy" and its metabolites impairs mitochondrial fusion/fission equilibrium and trafficking in hippocampal neurons, at in vivo relevant concentrations.
Topics: Adenosine Triphosphate; Animals; Axonal Transport; Calcium; Cell Survival; Cells, Cultured; Dose-Res | 2014 |
Serotonin reuptake transporter deficiency modulates the acute thermoregulatory and locomotor activity response to 3,4-(±)-methylenedioxymethamphetamine, and attenuates depletions in serotonin levels in SERT-KO rats.
Topics: Animals; Body Temperature; Body Temperature Regulation; Brain; Gene Knockdown Techniques; Hydroxyind | 2014 |
The effect of caffeine on MDMA-induced hydroxyl radical production in the mouse striatum.
Topics: Animals; Caffeine; Corpus Striatum; Dose-Response Relationship, Drug; Hydroxyl Radical; Male; Mice; | 2014 |
Vesicular monoamine transporter 2 and the acute and long-term response to 3,4-(±)-methylenedioxymethamphetamine.
Topics: 2H-Benzo(a)quinolizin-2-ol, 2-Ethyl-1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy-; Animals; Beh | 2015 |
MRI of toxic leukoencephalopathy syndrome associated with methylenedioxymethamphetamine.
Topics: Adolescent; Brain; Diagnosis, Differential; Humans; Leukoencephalopathies; Magnetic Resonance Imagin | 2015 |
Effect of MDMA-Induced Axotomy on the Dorsal Raphe Forebrain Tract in Rats: An In Vivo Manganese-Enhanced Magnetic Resonance Imaging Study.
Topics: Animals; Axons; Axotomy; Corpus Striatum; Dorsal Raphe Nucleus; Magnetic Resonance Imaging; Male; Ma | 2015 |
Caffeine alters the behavioural and body temperature responses to mephedrone without causing long-term neurotoxicity in rats.
Topics: Animals; Behavior, Animal; Body Temperature; Brain; Caffeine; Discrimination, Psychological; Dopamin | 2016 |
Effect of crowding, temperature and age on glia activation and dopaminergic neurotoxicity induced by MDMA in the mouse brain.
Topics: Aging; Analysis of Variance; Animals; Body Temperature; CD11b Antigen; Crowding; Disease Models, Ani | 2016 |
Hippocampal remodelling after MDMA neurotoxicity: a single case study.
Topics: Adolescent; Anticonvulsants; Body Temperature Regulation; Cognition Disorders; Electroencephalograph | 2009 |
Neurotoxic effects of ecstasy on the thalamus.
Topics: Adolescent; Adult; Amphetamine-Related Disorders; Cross-Sectional Studies; Female; Humans; Magnetic | 2008 |
N-acetylaspartate (NAA) correlates inversely with cannabis use in a frontal language processing region of neocortex in MDMA (Ecstasy) polydrug users: a 3 T magnetic resonance spectroscopy study.
Topics: Amphetamine-Related Disorders; Aspartic Acid; Biomarkers; Brain Chemistry; Female; Hallucinogens; Hu | 2009 |
Ecstasy-induced oxidative stress to adolescent rat brain mitochondria in vivo: influence of monoamine oxidase type A.
Topics: Animals; Animals, Newborn; Brain; Hallucinogens; Lipid Peroxidation; Mitochondria; Monoamine Oxidase | 2009 |
Dissociation between serotonin neurotoxicity and brain-derived neurotrophic factor induction following neonatal MDMA exposure in rats.
Topics: Aging; Animals; Animals, Newborn; Brain Chemistry; Brain-Derived Neurotrophic Factor; Cerebral Corte | 2009 |
Direct comparison of (+/-) 3,4-methylenedioxymethamphetamine ("ecstasy") disposition and metabolism in squirrel monkeys and humans.
Topics: 3,4-Methylenedioxyamphetamine; Adolescent; Animals; Brain; Chromatography, High Pressure Liquid; Dru | 2009 |
Further studies on the role of metabolites in (+/-)-3,4-methylenedioxymethamphetamine-induced serotonergic neurotoxicity.
Topics: 3,4-Methylenedioxyamphetamine; Animals; Deoxyepinephrine; Disease Models, Animal; Male; N-Methyl-3,4 | 2009 |
A study on the mechanisms by which minocycline protects against MDMA ('ecstasy')-induced neurotoxicity of 5-HT cortical neurons.
Topics: Animals; Drug Administration Schedule; Fever; Frontal Lobe; Hypothalamus; Inflammation; Interleukin- | 2010 |
Enzymatic-nonenzymatic cellular antioxidant defense systems response and immunohistochemical detection of MDMA, VMAT2, HSP70, and apoptosis as biomarkers for MDMA (Ecstasy) neurotoxicity.
Topics: Animals; Biomarkers; Brain; Chromatography, High Pressure Liquid; Disease Models, Animal; Electroche | 2010 |
Neural and cardiac toxicities associated with 3,4-methylenedioxymethamphetamine (MDMA).
Topics: Animals; Brain; Heart; Heart Valve Diseases; Humans; N-Methyl-3,4-methylenedioxyamphetamine; Neurons | 2009 |
Effect of acute brain tyrosine depletion on MDMA-induced changes in brain 5-HT.
Topics: Animals; Corpus Striatum; Dopamine; Fever; Hippocampus; Male; N-Methyl-3,4-methylenedioxyamphetamine | 2010 |
Effects of 3,4-methylenedioxymethamphetamine (MDMA) on serotonin transporter and vesicular monoamine transporter 2 protein and gene expression in rats: implications for MDMA neurotoxicity.
Topics: 5,7-Dihydroxytryptamine; Animals; Area Under Curve; Benzylamines; Brain; Central Nervous System Stim | 2010 |
Dopamine transporter down-regulation following repeated cocaine: implications for 3,4-methylenedioxymethamphetamine-induced acute effects and long-term neurotoxicity in mice.
Topics: Animals; Cell Membrane; Cocaine; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Prote | 2010 |
THC Prevents MDMA Neurotoxicity in Mice.
Topics: Animals; Astrocytes; Body Temperature; Dronabinol; Fever; Hallucinogens; Indoles; Mice; Mice, Inbred | 2010 |
Methylenedioxymethamphetamine inhibits mitochondrial complex I activity in mice: a possible mechanism underlying neurotoxicity.
Topics: Animals; Antioxidants; Corpus Striatum; Dopamine; Electron Transport Complex I; Free Radicals; Hallu | 2010 |
Chronic stress enhances the corticosterone response and neurotoxicity to +3,4-methylenedioxymethamphetamine (MDMA): the role of ambient temperature.
Topics: Animals; Body Temperature; Brain Chemistry; Chromatography, High Pressure Liquid; Corticosterone; Do | 2010 |
Comparative neurochemical profile of 3,4-methylenedioxymethamphetamine and its metabolite alpha-methyldopamine on key targets of MDMA neurotoxicity.
Topics: Animals; Cell Membrane; Cell Survival; Cocaine; Deoxyepinephrine; Dopamine; Dopamine Plasma Membrane | 2011 |
Evidence of neurotoxicity of ecstasy: sustained effects on electroencephalographic activity in polydrug users.
Topics: Adolescent; Adult; Alpha Rhythm; Attention Deficit Disorder with Hyperactivity; Electroencephalograp | 2010 |
The A2a adenosine receptor modulates the reinforcement efficacy and neurotoxicity of MDMA.
Topics: Animals; Anxiety; Astrocytes; Behavior, Animal; Body Temperature; Central Nervous System Stimulants; | 2011 |
Dopamine D2-receptor knockout mice are protected against dopaminergic neurotoxicity induced by methamphetamine or MDMA.
Topics: Analysis of Variance; Animals; Body Temperature; Central Nervous System Stimulants; Corpus Striatum; | 2011 |
Commentary on Halpern et al. (2011): strengthening the case against functionally significant serotonergic neurotoxicity in human MDMA (ecstasy) users.
Topics: Fenfluramine; Hallucinogens; Humans; N-Methyl-3,4-methylenedioxyamphetamine; Neurotoxicity Syndromes | 2011 |
Synthesis and neurotoxicity profile of 2,4,5-trihydroxymethamphetamine and its 6-(N-acetylcystein-S-yl) conjugate.
Topics: Acetylcysteine; Adrenergic Uptake Inhibitors; Animals; Brain; Hydroxyindoleacetic Acid; Male; Metham | 2011 |
Gender differences in hyperthermia and regional 5-HT and 5-HIAA depletion in the brain following MDMA administration in rats.
Topics: Animals; Brain; Disease Models, Animal; Female; Fever; Hydroxyindoleacetic Acid; Male; N-Methyl-3,4- | 2011 |
Residual neurocognitive features of ecstasy use: a re-interpretation of Halpern et al. (2011) consistent with serotonergic neurotoxicity.
Topics: Cognition; Humans; N-Methyl-3,4-methylenedioxyamphetamine; Neuropsychological Tests; Neurotoxicity S | 2011 |
Chronic administration of THC prevents the behavioral effects of intermittent adolescent MDMA administration and attenuates MDMA-induced hyperthermia and neurotoxicity in rats.
Topics: Adrenergic Uptake Inhibitors; Age Factors; Analysis of Variance; Animals; Animals, Newborn; Behavior | 2011 |
(±)-3,4-methylenedioxymethamphetamine and metabolite disposition in plasma and striatum of wild-type and multidrug resistance protein 1a knock-out mice.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; Biotransformation; Corpus Striatum; Data Int | 2011 |
Pharmacogenetic studies of change in cortisol on ecstasy (MDMA) consumption.
Topics: Adult; Amino Acid Substitution; Biomarkers; Biotransformation; Catechol O-Methyltransferase; Cohort | 2012 |
Behavioural and neuroinflammatory effects of the combination of binge ethanol and MDMA in mice.
Topics: Animals; Anxiety; Behavior, Animal; Body Temperature; Drug Interactions; Ethanol; Hallucinogens; Inf | 2012 |
Mapping serotonergic dysfunction in MDMA (ecstasy) users using pharmacological MRI.
Topics: Adult; Affect; Brain Mapping; Cerebrovascular Circulation; Cross-Sectional Studies; Hallucinogens; H | 2012 |
MDMA and 5-HT neurotoxicity: the empirical evidence for its adverse effects in humans - no need for translation.
Topics: Animals; Hallucinogens; Humans; N-Methyl-3,4-methylenedioxyamphetamine; Neurotoxicity Syndromes | 2012 |
The neurotoxicity of hallucinogenic amphetamines in primary cultures of hippocampal neurons.
Topics: Amphetamines; Animals; Apoptosis Inducing Factor; Biomarkers; Blotting, Western; Caspase 3; Caspase | 2013 |
Influence of chronic caffeine on MDMA-induced behavioral and neuroinflammatory response in mice.
Topics: Animals; Anxiety; Astrocytes; Behavior, Animal; Body Temperature; Caffeine; Central Nervous System S | 2013 |
Neurotoxicity of "ecstasy" and its metabolites in human dopaminergic differentiated SH-SY5Y cells.
Topics: 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt; Acetylcysteine; Buthionine Sulfoximine; Cell | 2013 |
Studies of (±)-3,4-methylenedioxymethamphetamine (MDMA) metabolism and disposition in rats and mice: relationship to neuroprotection and neurotoxicity profile.
Topics: Administration, Oral; Animals; Biotransformation; Body Temperature; Brain; Dopamine; Dose-Response R | 2013 |
MDMA can increase cortisol levels by 800% in dance clubbers.
Topics: Arginine Vasopressin; Catechol O-Methyltransferase; Cytochrome P-450 CYP2D6; Female; Humans; Hydroco | 2013 |
Reply to 'MDMA can increase cortical levels by 800% in dance clubbers' Parrott et al.
Topics: Arginine Vasopressin; Catechol O-Methyltransferase; Cytochrome P-450 CYP2D6; Female; Humans; Hydroco | 2013 |
Validity of [123I]beta-CIT SPECT in detecting MDMA-induced serotonergic neurotoxicity.
Topics: Animals; Autoradiography; Brain; Brain Mapping; Cocaine; Drug Administration Schedule; Iodine Radioi | 2002 |
"Ecstasy" and neurotoxic effects on the brain.
Topics: Brain Chemistry; Cerebrovascular Circulation; Glucose; Hallucinogens; Humans; N-Methyl-3,4-methylene | 2003 |
Relevance of MDMA ("ecstasy")-induced neurotoxicity to long-lasting psychomotor stimulation in mice.
Topics: Animals; Brain Chemistry; Carrier Proteins; Central Nervous System Stimulants; Cocaine; Dopamine; Do | 2003 |
Hypothalamic-pituitary-thyroid axis and sympathetic nervous system involvement in hyperthermia induced by 3,4-methylenedioxymethamphetamine (Ecstasy).
Topics: 3,4-Methylenedioxyamphetamine; Adrenergic alpha-Antagonists; Animals; Drug Interactions; Fever; Hypo | 2003 |
[On ecstasy].
Topics: Animals; Hallucinogens; Humans; N-Methyl-3,4-methylenedioxyamphetamine; Neurons; Neurotoxicity Syndr | 2003 |
Is frequent dosing with ecstasy a risky business for dopamine-containing neurons?
Topics: Animals; Dopamine; Dose-Response Relationship, Drug; Humans; N-Methyl-3,4-methylenedioxyamphetamine; | 2003 |
Response to O'Shea and Colado: the MDMA neurotoxicity profile might provide clues to mechanisms.
Topics: Animals; Dopamine; Dose-Response Relationship, Drug; Humans; N-Methyl-3,4-methylenedioxyamphetamine; | 2003 |
[Health problems of designer drugs].
Topics: Animals; Designer Drugs; Dopamine; Humans; N-Methyl-3,4-methylenedioxyamphetamine; Neurotoxicity Syn | 2003 |
Response to: Parrott AC, Buchanan T, Heffernan TM, Scholey A, Ling J, Rodgers J (2003) Parkinson's disorder, psychomotor problems and dopaminergic neurotoxicity in recreational ecstasy/MDMA users. Psychopharmacology 167(4):449-450.
Topics: Animals; Dopamine; Hallucinogens; Humans; Illicit Drugs; N-Methyl-3,4-methylenedioxyamphetamine; Neu | 2004 |
Editorial note: MDMA-induced dopamine neurotoxicity.
Topics: Animals; Dopamine; Hallucinogens; Humans; N-Methyl-3,4-methylenedioxyamphetamine; Neurotoxicity Synd | 2004 |
Long-lasting behavioral sensitization to psychostimulants following p-chloroamphetamine-induced neurotoxicity in mice.
Topics: Anesthetics, Local; Animals; Behavior, Animal; Binding Sites; Brain Chemistry; Carrier Proteins; Chr | 2004 |
Hyperthermic and neurotoxic effect of 3,4-methylenedioxymethamphetamine (MDMA) in guinea pigs.
Topics: Animals; Corpus Striatum; Dopamine; Dopamine Agents; Fever; Guinea Pigs; Male; N-Methyl-3,4-methylen | 2004 |
Brain concentrations of d-MDMA are increased after stress.
Topics: Animals; Body Temperature; Cold Temperature; Corpus Striatum; Dopamine; Female; Hypothermia; Mice; M | 2004 |
Ecstasy/MDMA and cannabis: the complexities of their interactive neuropsychobiological effects.
Topics: Cannabis; Drug Interactions; Hallucinogens; Humans; Marijuana Abuse; N-Methyl-3,4-methylenedioxyamph | 2004 |
Neurotoxicity of MDMA (ecstasy): beyond metabolism.
Topics: Animals; Mice; N-Methyl-3,4-methylenedioxyamphetamine; Neurons; Neurotoxicity Syndromes; Neurotoxins | 2005 |
Differential effects of amphetamines-induced neurotoxicity on appetitive and aversive Pavlovian conditioning in mice.
Topics: Amphetamines; Animals; Antimanic Agents; Appetitive Behavior; Avoidance Learning; Central Nervous Sy | 2005 |
Taking Ecstasy... it's child's play!
Topics: Anticonvulsants; Critical Illness; Exanthema; Female; Hallucinogens; Hemodynamics; Humans; Hyponatre | 2005 |
Studies on the effect of MDMA ('ecstasy') on the body temperature of rats housed at different ambient room temperatures.
Topics: Animals; Body Temperature; Brain Chemistry; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; | 2005 |
MDMA (Ecstasy) and human dopamine, norepinephrine, and serotonin transporters: implications for MDMA-induced neurotoxicity and treatment.
Topics: Binding, Competitive; Brain; Cell Line; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dose- | 2007 |
"Ecstasy"-induced neurotoxicity: the contribution of functional brain imaging.
Topics: Animals; Brain; Diagnostic Imaging; Humans; N-Methyl-3,4-methylenedioxyamphetamine; Neurotoxicity Sy | 2006 |
Repeated adolescent 3,4-methylenedioxymethamphetamine (MDMA) exposure in rats attenuates the effects of a subsequent challenge with MDMA or a 5-hydroxytryptamine(1A) receptor agonist.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Animals; Behavior, Animal; Body Weight; Dose-Response | 2006 |
[Long-term neurotoxic effects of MDMA result in cortical and hippocampal structural changes].
Topics: Animals; Cerebral Cortex; Diazepam Binding Inhibitor; Hippocampus; Male; N-Methyl-3,4-methylenedioxy | 2006 |
Protection against MDMA-induced dopaminergic neurotoxicity in mice by methyllycaconitine: involvement of nicotinic receptors.
Topics: Aconitine; Analysis of Variance; Animals; Cocaine; Disease Models, Animal; Dopamine; Dopamine Uptake | 2006 |
Binge ethanol administration enhances the MDMA-induced long-term 5-HT neurotoxicity in rat brain.
Topics: Acetaldehyde; Alcoholic Intoxication; Aldehyde Dehydrogenase; Animals; Body Temperature; Brain; Cent | 2007 |
Factors contributing to the enhancement of MDMA-induced 5-HT depletion by ethanol: a reply to Byron and Cassel.
Topics: Alcoholic Intoxication; Animals; Brain; Central Nervous System Depressants; Drug Interactions; Ethan | 2007 |
Ethanol and MDMA: a comment on the paper by Izco et al.
Topics: Alcoholic Intoxication; Animals; Body Temperature; Brain; Central Nervous System Depressants; Drug S | 2007 |
Evidence for a role of Hsp70 in the neuroprotection induced by heat shock pre-treatment against 3,4-methylenedioxymethamphetamine toxicity in rat brain.
Topics: Animals; Body Temperature; Brain; Brain Chemistry; Epistasis, Genetic; Fluoxetine; Gene Expression R | 2007 |
Is there a case for MDMA-assisted psychotherapy in the UK?
Topics: Hallucinogens; History, 20th Century; Humans; Illicit Drugs; N-Methyl-3,4-methylenedioxyamphetamine; | 2007 |
Dissociation of the neurochemical and behavioral toxicology of MDMA ('Ecstasy') by citalopram.
Topics: Analysis of Variance; Animals; Behavior, Animal; Body Temperature; Body Weight; Brain Chemistry; Cit | 2008 |
Monoamine oxidase-B mediates ecstasy-induced neurotoxic effects to adolescent rat brain mitochondria.
Topics: Age Factors; Animals; Brain; Lipid Peroxidation; Male; Mitochondria; Monoamine Oxidase; Monoamine Ox | 2007 |
The relationship between core body temperature and 3,4-methylenedioxymethamphetamine metabolism in rats: implications for neurotoxicity.
Topics: Animals; Body Temperature; Brain Chemistry; Catechol O-Methyltransferase; Catechol O-Methyltransfera | 2008 |
On the role of tyrosine and peripheral metabolism in 3,4-methylenedioxymethamphetamine-induced serotonin neurotoxicity in rats.
Topics: Analysis of Variance; Animals; Antimetabolites; Area Under Curve; Body Temperature; Brain; Catechols | 2008 |
Memantine protects against amphetamine derivatives-induced neurotoxic damage in rodents.
Topics: Animals; Benzamides; Body Temperature; Bridged Bicyclo Compounds; Dizocilpine Maleate; Dopamine Anta | 2008 |
A neurotoxic regimen of MDMA suppresses behavioral, thermal and neurochemical responses to subsequent MDMA administration.
Topics: Animals; Behavior, Animal; Body Temperature; Brain Chemistry; Dopamine; Dose-Response Relationship, | 1999 |
MDMA (Ecstasy) neurotoxicity: assessing and communicating the risks.
Topics: Animals; Hallucinogens; Health Education; Humans; N-Methyl-3,4-methylenedioxyamphetamine; Neurotoxic | 2000 |
'Is MDMA a human neurotoxin?': diverse views from the discussants.
Topics: Animals; Hallucinogens; Humans; N-Methyl-3,4-methylenedioxyamphetamine; Neurotoxicity Syndromes; Rat | 2000 |
Does recreational ecstasy use cause long-term cognitive problems?
Topics: Animals; Cognition Disorders; Humans; Illicit Drugs; N-Methyl-3,4-methylenedioxyamphetamine; Neuroto | 2000 |
The effect of (R)-HA966 or ACEA 1021 on dexfenfluramine or (S)-MDMA-induced changes in temperature, activity, and neurotoxicity.
Topics: Animals; Autoradiography; Body Temperature; Brain Chemistry; Carrier Proteins; Chromatography, High | 2001 |
Involvement of free radicals in MDMA-induced neurotoxicity in mice.
Topics: Animals; Brain Chemistry; Catalase; Disease Models, Animal; Free Radicals; Gene Expression Regulatio | 2001 |
A neurotoxic dose of 3,4-methylenedioxymethamphetamine (MDMA; ecstasy) to rats results in a long-term defect in thermoregulation.
Topics: Amphetamines; Animals; Body Temperature; Body Temperature Regulation; Brain Chemistry; Hallucinogens | 2001 |
Serotonergic neurotoxicity of 3,4-(+/-)-methylenedioxyamphetamine and 3,4-(+/-)-methylendioxymethamphetamine (ecstasy) is potentiated by inhibition of gamma-glutamyl transpeptidase.
Topics: 3,4-Methylenedioxyamphetamine; Administration, Cutaneous; Animals; Brain; Endothelium; Enzyme Inhibi | 2001 |
Cortical serotonin transporter density and verbal memory in individuals who stopped using 3,4-methylenedioxymethamphetamine (MDMA or "ecstasy"): preliminary findings.
Topics: Adult; Brain Chemistry; Carrier Proteins; Cerebral Cortex; Cocaine; Female; Follow-Up Studies; Human | 2001 |
"Ecstasy" and serotonin neurotoxicity: new findings raise more questions.
Topics: Brain Chemistry; Carrier Proteins; Cerebral Cortex; Cocaine; Follow-Up Studies; Humans; Membrane Gly | 2001 |
Electrophysiological evidence of serotonergic impairment in long-term MDMA ("ecstasy") users.
Topics: Acoustic Stimulation; Adult; Auditory Perception; Dose-Response Relationship, Drug; Dronabinol; Elec | 2001 |