n-methyl-3,4-methylenedioxyamphetamine has been researched along with Disease Models, Animal in 79 studies
N-Methyl-3,4-methylenedioxyamphetamine: An N-substituted amphetamine analog. It is a widely abused drug classified as a hallucinogen and causes marked, long-lasting changes in brain serotonergic systems. It is commonly referred to as MDMA or ecstasy.
3,4-methylenedioxymethamphetamine : A member of the class of benzodioxoles that is 1,3-benzodioxole substituted by a 2-(methylamino)propyl group at position 5.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Our experiments were designed to examine the effects of a concomitant administration of 3,4-methylenedioxy-methamphetamine (MDMA) and mephedrone on depression- and anxiety-like behaviors and cognitive processes in Swiss mice." | 3.85 | Acute behavioral effects of co-administration of mephedrone and MDMA in mice. ( Biała, G; Budzynska, B; Frankowska, M; Kaszubska, K; Michalak, A, 2017) |
| " Repeated exposure to MDMA (3×10mg/kg, ip) resulted in a reduction of 37-58% of GAD67-IR cells in the dentate gyrus (DG), CA1, and CA3 regions, as well as an increased susceptibility to kainic acid-induced seizures, both of which persisted for at least 30days following MDMA treatment." | 3.83 | MDMA decreases glutamic acid decarboxylase (GAD) 67-immunoreactive neurons in the hippocampus and increases seizure susceptibility: Role for glutamate. ( Gudelsky, GA; Herman, JP; Huff, CL; Morano, RL; Yamamoto, BK, 2016) |
| "Drug abuse is a global problem of considerable concern to health." | 2.42 | Methylenedioxymethamphetamine (MDMA, 'Ecstasy'): a stressor on the immune system. ( Connor, TJ, 2004) |
| "Locomotor activity and conditioned place preference dose-response curves were generated at 20±2°C for two amphetamine analogues (MDMA and methamphetamine [METH]) and two cathinone analogues (MDPV and α-pyrrolidinopentiophenone [αPVP]) in mice." | 1.91 | Effects of ambient temperature on locomotor activity and place conditioning elicited by abused psychostimulants in mice: Role of 3,4-methylenedioxy moiety. ( Fantegrossi, WE; Fitzgerald, LR; Gannon, BM; Godwin, CO; Hughes-Meredith, HD; Rice, KC, 2023) |
| "Methylenedioxymethamphetamine (MDMA) and methcathinone (MCAT) are abused psychostimulant drugs that produce adverse effects in human users that include hepatotoxicity and death." | 1.56 | High ambient temperature increases the toxicity and lethality of 3,4-methylenedioxymethamphetamine and methcathinone. ( Chen, Y; Hall, FS; Saber, YH; Tran, HTN, 2020) |
| "In turn, new hypotheses suggest that Alzheimer's disease (AD) may be promoted by neural stressors." | 1.51 | Effects of MDMA on neuroplasticity, amyloid burden and phospho-tau expression in APPswe/PS1dE9 mice. ( Abad, S; Camarasa, J; Camins, A; Escubedo, E; Folch, J; López-Arnau, R; Pubill, D; Ramon-Duaso, C, 2019) |
| " The results demonstrate that chronic administration of MDMA during late adolescence in mice exacerbates the neurodegeneration and neuroinflammation caused by MPTP, suggesting that MDMA may constitute a risk factor for dopaminergic neuron degeneration." | 1.39 | MPTP-induced dopamine neuron degeneration and glia activation is potentiated in MDMA-pretreated mice. ( Costa, G; Frau, L; Morelli, M; Pinna, A; Plumitallo, A; Wardas, J, 2013) |
| "Mirtazapine is a novel antidepressant and a potent 5-HT(2A) receptor antagonist." | 1.37 | The effects of mirtazapine and fluoxetine on hyperthermia induced by 3,4-methylenedioxymethamphetamine (MDMA) in rats. ( Iwamura, T; Kasai, M; Kato, S; Nisijima, K; Shioda, K; Yoshino, T, 2011) |
| " THC unexpectedly produced a modest hyperthermic effect when administered alone, but in animals co-treated with both THC and MDMA, there was an attenuation of MDMA-induced hyperthermia on dosing days." | 1.37 | Chronic administration of THC prevents the behavioral effects of intermittent adolescent MDMA administration and attenuates MDMA-induced hyperthermia and neurotoxicity in rats. ( Ali, SF; Meyer, JS; Shen, EY, 2011) |
| " Acute hyperthermia, plasma tyrosine levels and concentrations of MDMA and its main metabolites were higher after a toxic (15 mg/kg i." | 1.35 | On the role of tyrosine and peripheral metabolism in 3,4-methylenedioxymethamphetamine-induced serotonin neurotoxicity in rats. ( Aguirre, N; de la Torre, R; Goñi-Allo, B; Hervias, I; Lasheras, B; Mathúna, BO; Puerta, E, 2008) |
| "When caffeine was administered prior to MDMA, a potentiation of locomotor activity was observed, which consisted in an increase in maximal values and in a prolonged time of activity." | 1.33 | Association of caffeine to MDMA does not increase antinociception but potentiates adverse effects of this recreational drug. ( Camarasa, J; Escubedo, E; Pubill, D, 2006) |
| " Administration of MDMA leads to the formation of metabolites responsible for its toxic effects on serotonergic neurons in rats and non-human primates and on dopaminergic neurons in mice." | 1.31 | Involvement of free radicals in MDMA-induced neurotoxicity in mice. ( Cadet, JL; Jayanthi, S; Thiriet, N, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (2.53) | 18.2507 |
| 2000's | 33 (41.77) | 29.6817 |
| 2010's | 36 (45.57) | 24.3611 |
| 2020's | 8 (10.13) | 2.80 |
| Authors | Studies |
|---|---|
| Arluk, S | 1 |
| Matar, MA | 1 |
| Carmi, L | 1 |
| Arbel, O | 1 |
| Zohar, J | 1 |
| Todder, D | 1 |
| Cohen, H | 1 |
| Gannon, BM | 1 |
| Fitzgerald, LR | 1 |
| Godwin, CO | 1 |
| Hughes-Meredith, HD | 1 |
| Rice, KC | 1 |
| Fantegrossi, WE | 1 |
| Chen, Y | 1 |
| Tran, HTN | 1 |
| Saber, YH | 1 |
| Hall, FS | 1 |
| Costa, G | 2 |
| Spulber, S | 1 |
| Paci, E | 1 |
| Casu, MA | 1 |
| Ceccatelli, S | 1 |
| Simola, N | 2 |
| Morelli, M | 3 |
| Chaliha, D | 1 |
| Mamo, JC | 1 |
| Albrecht, M | 1 |
| Lam, V | 1 |
| Takechi, R | 1 |
| Vaccarezza, M | 1 |
| Sgambato, V | 2 |
| García-Pardo, MP | 2 |
| De la Rubia Ortí, JE | 1 |
| Calpe-López, C | 1 |
| Aguilar, MA | 4 |
| Pérez-Hernández, M | 1 |
| Fernández-Valle, ME | 1 |
| Rubio-Araiz, A | 1 |
| Vidal, R | 1 |
| Gutiérrez-López, MD | 1 |
| O'Shea, E | 1 |
| Colado, MI | 1 |
| Météreau, E | 3 |
| Beaudoin-Gobert, M | 3 |
| Duperrier, S | 3 |
| Thobois, S | 3 |
| Tremblay, L | 3 |
| Sgambato-Faure, V | 2 |
| Dolan, SB | 1 |
| Chen, Z | 1 |
| Huang, R | 1 |
| Gatch, MB | 1 |
| Abad, S | 1 |
| Ramon-Duaso, C | 1 |
| López-Arnau, R | 1 |
| Folch, J | 1 |
| Pubill, D | 4 |
| Camarasa, J | 4 |
| Camins, A | 1 |
| Escubedo, E | 4 |
| van de Wetering, R | 1 |
| Schenk, S | 3 |
| Ciudad-Roberts, A | 1 |
| Rodríguez-Arias, M | 3 |
| Valverde, O | 1 |
| Daza-Losada, M | 2 |
| Blanco-Gandía, MC | 1 |
| Miñarro, J | 3 |
| Frau, L | 2 |
| Wardas, J | 1 |
| Pinna, A | 1 |
| Plumitallo, A | 1 |
| Kiyatkin, EA | 1 |
| Kim, AH | 1 |
| Wakabayashi, KT | 1 |
| Baumann, MH | 2 |
| Shaham, Y | 1 |
| Lizarraga, LE | 1 |
| Cholanians, AB | 1 |
| Phan, AV | 1 |
| Herndon, JM | 1 |
| Lau, SS | 1 |
| Monks, TJ | 1 |
| Macaskill, AC | 1 |
| Harrow, CC | 1 |
| Harper, DN | 2 |
| McDonnell-Dowling, K | 1 |
| Kelly, JP | 2 |
| Epinat, J | 1 |
| Neumane, S | 1 |
| Ballanger, B | 1 |
| Lavenne, F | 1 |
| Liger, F | 1 |
| Tourvielle, C | 1 |
| Bonnefoi, F | 1 |
| Costes, N | 1 |
| Bars, DL | 1 |
| Broussolle, E | 1 |
| Ball, KT | 1 |
| Jarsocrak, H | 1 |
| Hyacinthe, J | 1 |
| Lambert, J | 1 |
| Lockowitz, J | 1 |
| Schrock, J | 1 |
| Porceddu, PF | 1 |
| Huff, CL | 1 |
| Morano, RL | 1 |
| Herman, JP | 1 |
| Yamamoto, BK | 1 |
| Gudelsky, GA | 1 |
| Roger-Sánchez, C | 1 |
| Budzynska, B | 1 |
| Michalak, A | 1 |
| Frankowska, M | 1 |
| Kaszubska, K | 1 |
| Biała, G | 1 |
| Shioda, K | 2 |
| Nisijima, K | 2 |
| Yoshino, T | 2 |
| Kuboshima, K | 1 |
| Iwamura, T | 2 |
| Yui, K | 1 |
| Kato, S | 2 |
| de Paula, VF | 1 |
| Ribeiro, A | 2 |
| Pinheiro, ML | 2 |
| Sakai, M | 1 |
| Lacava, MC | 1 |
| Lapachinske, SF | 2 |
| Moreau, RL | 2 |
| Palermo-Neto, J | 2 |
| León, LA | 1 |
| Landeira-Fernandez, J | 1 |
| Cardenas, FP | 1 |
| Bissette, G | 1 |
| Mueller, M | 1 |
| Yuan, J | 1 |
| Felim, A | 1 |
| Neudörffer, A | 1 |
| Peters, FT | 1 |
| Maurer, HH | 1 |
| McCann, UD | 1 |
| Largeron, M | 1 |
| Ricaurte, GA | 1 |
| Riezzo, I | 1 |
| Cerretani, D | 1 |
| Fiore, C | 1 |
| Bello, S | 1 |
| Centini, F | 1 |
| D'Errico, S | 1 |
| Fiaschi, AI | 1 |
| Giorgi, G | 1 |
| Neri, M | 1 |
| Pomara, C | 1 |
| Turillazzi, E | 1 |
| Fineschi, V | 2 |
| Nawata, Y | 1 |
| Hiranita, T | 1 |
| Yamamoto, T | 1 |
| Gouzoulis-Mayfrank, E | 1 |
| Daumann, J | 1 |
| van Donkelaar, EL | 1 |
| Kelly, PA | 1 |
| Dawson, N | 1 |
| Blokland, A | 1 |
| Prickaerts, J | 1 |
| Steinbusch, HW | 1 |
| Ferrington, L | 1 |
| Biezonski, DK | 1 |
| Meyer, JS | 2 |
| Jaehne, EJ | 1 |
| Majumder, I | 2 |
| Salem, A | 1 |
| Irvine, RJ | 2 |
| Stove, CP | 1 |
| De Letter, EA | 1 |
| Piette, MH | 1 |
| Lambert, WE | 1 |
| Edut, S | 1 |
| Rubovitch, V | 1 |
| Schreiber, S | 1 |
| Pick, CG | 1 |
| Nelson, DA | 1 |
| Singh, SJ | 1 |
| Young, AB | 1 |
| Tolbert, MD | 1 |
| Bost, KL | 1 |
| Kay, C | 1 |
| Hunt, M | 1 |
| Wallinga, AE | 1 |
| Grahlmann, C | 1 |
| Granneman, RA | 1 |
| Koolhaas, JM | 1 |
| Buwalda, B | 1 |
| Kasai, M | 1 |
| Shen, EY | 1 |
| Ali, SF | 1 |
| White, JM | 1 |
| Stankevicius, D | 1 |
| Ferraz-de-Paula, V | 1 |
| Ligeiro de Oliveira, AP | 1 |
| Damazo, AS | 1 |
| Tavares de Lima, W | 1 |
| Bird, J | 1 |
| Schaefer, TL | 1 |
| Grace, CE | 1 |
| Braun, AA | 1 |
| Amos-Kroohs, RM | 1 |
| Graham, DL | 1 |
| Skelton, MR | 1 |
| Williams, MT | 1 |
| Vorhees, CV | 1 |
| Cole, JC | 1 |
| Sumnall, HR | 1 |
| Blessing, WW | 2 |
| Seaman, B | 1 |
| Pedersen, NP | 1 |
| Ootsuka, Y | 1 |
| Iravani, MM | 1 |
| Jackson, MJ | 1 |
| Kuoppamäki, M | 1 |
| Smith, LA | 1 |
| Jenner, P | 1 |
| Connor, TJ | 2 |
| Rusyniak, DE | 1 |
| Banks, ML | 1 |
| Mills, EM | 1 |
| Sprague, JE | 1 |
| Rosa-Neto, P | 1 |
| Olsen, AK | 1 |
| Gjedde, A | 1 |
| Watanabe, H | 1 |
| Cumming, P | 1 |
| Clark, RD | 1 |
| Budzynski, AG | 1 |
| Partilla, JS | 1 |
| Blough, BE | 1 |
| Rothman, RB | 1 |
| Parrott, AC | 1 |
| Lebsanft, HB | 1 |
| Kohles, T | 1 |
| Kovar, KA | 1 |
| Schmidt, WJ | 1 |
| Leslie, M | 1 |
| Easton, N | 1 |
| Marsden, CA | 1 |
| Lyvers, M | 1 |
| Reinhard, C | 1 |
| Wolffgramm, J | 1 |
| Chipana, C | 1 |
| Clemens, KJ | 1 |
| McGregor, IS | 1 |
| Hunt, GE | 1 |
| Cornish, JL | 1 |
| Cassel, JC | 1 |
| Ben Hamida, S | 1 |
| Jones, BC | 1 |
| Frenzilli, G | 1 |
| Ferrucci, M | 1 |
| Giorgi, FS | 1 |
| Blandini, F | 1 |
| Nigro, M | 1 |
| Ruggieri, S | 1 |
| Murri, L | 1 |
| Paparelli, A | 1 |
| Fornai, F | 1 |
| Kobeissy, FH | 1 |
| Jeung, JA | 1 |
| Warren, MW | 1 |
| Geier, JE | 1 |
| Gold, MS | 1 |
| Schierenbeck, T | 1 |
| Riemann, D | 1 |
| Berger, M | 1 |
| Hornyak, M | 1 |
| Goñi-Allo, B | 1 |
| Puerta, E | 1 |
| Mathúna, BO | 1 |
| Hervias, I | 1 |
| Lasheras, B | 1 |
| de la Torre, R | 1 |
| Aguirre, N | 1 |
| Hashimoto, K | 1 |
| Nakahara, Y | 1 |
| Kikura, R | 1 |
| Scearce-Levie, K | 1 |
| Chen, JP | 1 |
| Gardner, E | 1 |
| Hen, R | 1 |
| Maldonado, E | 1 |
| Navarro, JF | 1 |
| Harkin, A | 1 |
| Mulrooney, J | 1 |
| Leonard, BE | 1 |
| Cadet, JL | 1 |
| Thiriet, N | 1 |
| Jayanthi, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effects of MDMA on Prefrontal and Amygdala Activation in Posttraumatic Stress Disorder[NCT03752918] | Phase 1 | 20 participants (Anticipated) | Interventional | 2024-01-31 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
14 reviews available for n-methyl-3,4-methylenedioxyamphetamine and Disease Models, Animal
| Article | Year |
|---|---|
A Systematic Review of the MDMA Model to Address Social Impairment in Autism.
Topics: Animals; Autism Spectrum Disorder; Autistic Disorder; Disease Models, Animal; Humans; N-Methyl-3,4-m | 2021 |
Sources of variation in the design of preclinical studies assessing the effects of amphetamine-type stimulants in pregnancy and lactation.
Topics: Amphetamine; Amphetamines; Animals; Animals, Newborn; Central Nervous System Stimulants; Disease Mod | 2015 |
Does Alzheimer's disease result from attempts at repair or protection after transient stress?
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Craniocerebral Tr | 2009 |
Neurotoxicity of drugs of abuse--the case of methylenedioxyamphetamines (MDMA, ecstasy), and amphetamines.
Topics: Amphetamines; Animals; Brain; Disease Models, Animal; Humans; N-Methyl-3,4-methylenedioxyamphetamine | 2009 |
Mice in ecstasy: advanced animal models in the study of MDMA.
Topics: Animals; Behavior, Animal; Brain; Disease Models, Animal; Hallucinogens; Humans; Mice; Mice, Transge | 2010 |
MDMA ("ecstasy") abuse as an example of dopamine neuroplasticity.
Topics: Animals; Central Nervous System Stimulants; Discrimination, Psychological; Disease Models, Animal; D | 2011 |
The pre-clinical behavioural pharmacology of 3,4-methylenedioxymethamphetamine (MDMA).
Topics: Animals; Behavior, Animal; Brain; Carrier Proteins; Conditioning, Psychological; Discrimination Lear | 2003 |
Methylenedioxymethamphetamine (MDMA, 'Ecstasy'): a stressor on the immune system.
Topics: Animals; Disease Models, Animal; Hallucinogens; Humans; Immune System; Immune Tolerance; N-Methyl-3, | 2004 |
MDMA (3,4-Methylenedioxymethamphetamine) or ecstasy: the neuropsychobiological implications of taking it at dances and raves.
Topics: Animals; Dancing; Disease Models, Animal; Environment; Hallucinogens; Humans; Illicit Drugs; N-Methy | 2004 |
Ecstasy: are animal data consistent between species and can they translate to humans?
Topics: Amphetamine-Related Disorders; Animals; Arousal; Body Temperature Regulation; Brain; Disease Models, | 2006 |
Recreational ecstasy use and the neurotoxic potential of MDMA: current status of the controversy and methodological issues.
Topics: Amphetamine-Related Disorders; Animals; Brain; Cognition Disorders; Diagnostic Imaging; Disease Mode | 2006 |
MDMA, methamphetamine and their combination: possible lessons for party drug users from recent preclinical research.
Topics: Amphetamine-Related Disorders; Animals; Behavior, Animal; Brain; Disease Models, Animal; Drug Evalua | 2007 |
Effect of illicit recreational drugs upon sleep: cocaine, ecstasy and marijuana.
Topics: Animals; Brain; Cocaine; Disease Models, Animal; Dronabinol; Humans; Illicit Drugs; N-Methyl-3,4-met | 2008 |
[Minocycline as a therapeutic drug for methamphetamine use disorders].
Topics: Animals; Anti-Bacterial Agents; Brain; Disease Models, Animal; Humans; Methamphetamine; Minocycline; | 2008 |
65 other studies available for n-methyl-3,4-methylenedioxyamphetamine and Disease Models, Animal
| Article | Year |
|---|---|
MDMA treatment paired with a trauma-cue promotes adaptive stress responses in a translational model of PTSD in rats.
Topics: Animals; Anti-Anxiety Agents; Cues; Disease Models, Animal; Hypothalamo-Hypophyseal System; N-Methyl | 2022 |
Effects of ambient temperature on locomotor activity and place conditioning elicited by abused psychostimulants in mice: Role of 3,4-methylenedioxy moiety.
Topics: Animals; Central Nervous System Stimulants; Conditioning, Operant; Disease Models, Animal; Dose-Resp | 2023 |
High ambient temperature increases the toxicity and lethality of 3,4-methylenedioxymethamphetamine and methcathinone.
Topics: Ammonia; Animals; Brain; Central Nervous System Stimulants; Disease Models, Animal; Female; Glutamic | 2020 |
In utero exposure to dexamethasone causes a persistent and age-dependent exacerbation of the neurotoxic effects and glia activation induced by MDMA in dopaminergic brain regions of C57BL/6J mice.
Topics: Age Factors; Animals; Brain; Calcium-Binding Proteins; Dexamethasone; Disease Models, Animal; Diseas | 2021 |
Breathing new life into neurotoxic-based monkey models of Parkinson's disease to study the complex biological interplay between serotonin and dopamine.
Topics: Animals; Diffusion Tensor Imaging; Disease Models, Animal; Dopamine; Haplorhini; Humans; Levodopa; N | 2021 |
Role of acute social stress in the rewarding effects of MDMA in adolescent mice.
Topics: Age Factors; Animals; Behavior, Animal; Central Nervous System Stimulants; Conditioning, Classical; | 2021 |
3,4-Methylenedioxymethamphetamine (MDMA, ecstasy) produces edema due to BBB disruption induced by MMP-9 activation in rat hippocampus.
Topics: Animals; Aquaporin 4; Blood-Brain Barrier; Brain Edema; Claudin-5; Disease Models, Animal; Enzyme In | 2017 |
Diffusion tensor imaging marks dopaminergic and serotonergic lesions in the Parkinsonian monkey.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Brain; Diffusion Tensor Imaging; Disease Mode | 2018 |
"Ecstasy" to addiction: Mechanisms and reinforcing effects of three synthetic cathinone analogs of MDMA.
Topics: Animals; Benzazepines; Central Nervous System Stimulants; Conditioning, Operant; Disease Models, Ani | 2018 |
Pathophysiology of levodopa-induced dyskinesia: Insights from multimodal imaging and immunohistochemistry in non-human primates.
Topics: Animals; Brain; Diffusion Tensor Imaging; Disease Models, Animal; Dopamine Agents; Dyskinesia, Drug- | 2018 |
Effects of MDMA on neuroplasticity, amyloid burden and phospho-tau expression in APPswe/PS1dE9 mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Cognitive Dysfunction; Disease Models, Ani | 2019 |
Regional changes in ∆FosB expression in rat brain following MDMA self-administration predict increased sensitivity to effects of locally infused MDMA.
Topics: Adrenergic Uptake Inhibitors; Animals; Brain; Disease Models, Animal; Male; N-Methyl-3,4-methylenedi | 2020 |
Heteromeric nicotinic receptors are involved in the sensitization and addictive properties of MDMA in mice.
Topics: Analysis of Variance; Animals; Benzazepines; Brain; Cholinergic Agents; Conditioning, Operant; Dihyd | 2013 |
Assessment of the abuse potential of MDMA in the conditioned place preference paradigm: role of CB1 receptors.
Topics: 3,4-Dihydroxyphenylacetic Acid; Analysis of Variance; Animals; Brain; Conditioning, Operant; Disease | 2013 |
MPTP-induced dopamine neuron degeneration and glia activation is potentiated in MDMA-pretreated mice.
Topics: Adrenergic Uptake Inhibitors; Animals; Brain; CD11b Antigen; Cell Count; Disease Models, Animal; Dop | 2013 |
Critical role of peripheral vasoconstriction in fatal brain hyperthermia induced by MDMA (Ecstasy) under conditions that mimic human drug use.
Topics: Animals; Body Temperature; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Fever; H | 2014 |
Vesicular monoamine transporter 2 and the acute and long-term response to 3,4-(±)-methylenedioxymethamphetamine.
Topics: 2H-Benzo(a)quinolizin-2-ol, 2-Ethyl-1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy-; Animals; Beh | 2015 |
The disruptive effects of methamphetamine on delayed-matching-to-sample performance reflect proactive interference and are reduced by SCH23390.
Topics: Amphetamine-Related Disorders; Animals; Benzazepines; Central Nervous System Stimulants; Disease Mod | 2015 |
Behavioural impact of a double dopaminergic and serotonergic lesion in the non-human primate.
Topics: Aniline Compounds; Animals; Antiparkinson Agents; Brain; Brain Mapping; Chlorocebus aethiops; Diseas | 2015 |
Yohimbine reinstates extinguished 3,4-methylenedioxymethamphetamine (MDMA; ecstasy) seeking in rats with prior exposure to chronic yohimbine.
Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Behavior, Addictive; Benzazepines; Conditioning, O | 2015 |
Effect of crowding, temperature and age on glia activation and dopaminergic neurotoxicity induced by MDMA in the mouse brain.
Topics: Aging; Analysis of Variance; Animals; Body Temperature; CD11b Antigen; Crowding; Disease Models, Ani | 2016 |
MDMA decreases glutamic acid decarboxylase (GAD) 67-immunoreactive neurons in the hippocampus and increases seizure susceptibility: Role for glutamate.
Topics: Animals; Body Temperature; Disease Models, Animal; Dizocilpine Maleate; Excitatory Amino Acid Agonis | 2016 |
Cognitive and behavioural effects induced by social stress plus MDMA administration in mice.
Topics: Analysis of Variance; Animals; Avoidance Learning; Behavioral Symptoms; Body Temperature; Cognition | 2017 |
Acute behavioral effects of co-administration of mephedrone and MDMA in mice.
Topics: Animals; Antidepressive Agents; Anxiety; Cognition; Depression; Disease Models, Animal; Drug Interac | 2017 |
Risperidone attenuates and reverses hyperthermia induced by 3,4-methylenedioxymethamphetamine (MDMA) in rats.
Topics: Analysis of Variance; Animals; Body Temperature; Disease Models, Animal; Dopamine; Dopamine Antagoni | 2008 |
Methylenedioxymethamphetamine (Ecstasy) decreases neutrophil activity and alters leukocyte distribution in bone marrow, spleen and blood.
Topics: Animals; Bone Marrow Cells; Corticosterone; Disease Models, Animal; Hallucinogens; Hypothalamo-Hypop | 2009 |
Effects of chronic intracerebroventricular 3,4-methylenedioxy-N-methamphetamine (MDMA) or fluoxetine on the active avoidance test in rats with or without exposure to mild chronic stress.
Topics: Analysis of Variance; Animals; Avoidance Learning; Chronic Disease; Depression; Disease Models, Anim | 2009 |
Further studies on the role of metabolites in (+/-)-3,4-methylenedioxymethamphetamine-induced serotonergic neurotoxicity.
Topics: 3,4-Methylenedioxyamphetamine; Animals; Deoxyepinephrine; Disease Models, Animal; Male; N-Methyl-3,4 | 2009 |
Acquisition and reinstatement of MDMA-induced conditioned place preference in mice pre-treated with MDMA or cocaine during adolescence.
Topics: Age Factors; Animals; Choice Behavior; Cocaine; Conditioning, Psychological; Disease Models, Animal; | 2009 |
Enzymatic-nonenzymatic cellular antioxidant defense systems response and immunohistochemical detection of MDMA, VMAT2, HSP70, and apoptosis as biomarkers for MDMA (Ecstasy) neurotoxicity.
Topics: Animals; Biomarkers; Brain; Chromatography, High Pressure Liquid; Disease Models, Animal; Electroche | 2010 |
A cannabinoid CB(1) receptor antagonist ameliorates impairment of recognition memory on withdrawal from MDMA (Ecstasy).
Topics: Analysis of Variance; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Admini | 2010 |
Acute tryptophan depletion potentiates 3,4-methylenedioxymethamphetamine-induced cerebrovascular hyperperfusion in adult male Wistar rats.
Topics: Animals; Binding, Competitive; Brain; Cerebral Arteries; Cerebrovascular Circulation; Cerebrovascula | 2010 |
Effects of 3,4-methylenedioxymethamphetamine (MDMA) on serotonin transporter and vesicular monoamine transporter 2 protein and gene expression in rats: implications for MDMA neurotoxicity.
Topics: 5,7-Dihydroxytryptamine; Animals; Area Under Curve; Benzylamines; Brain; Central Nervous System Stim | 2010 |
Increased effects of 3,4-methylenedioxymethamphetamine (ecstasy) in a rat model of depression.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Arousal; Body Temperature Regulation; Brain; Cerebral Corte | 2011 |
MDMA (ecstasy) toxicity: pharmacolinetic, metabolism, cell response and pathological consequences.
Topics: Animals; Cell Physiological Phenomena; Disease Models, Animal; Hallucinogens; Humans; N-Methyl-3,4-m | 2010 |
The intriguing effects of ecstasy (MDMA) on cognitive function in mice subjected to a minimal traumatic brain injury (mTBI).
Topics: Animals; Behavior, Animal; Blotting, Western; Brain; Brain Injuries; Cognition; Disease Models, Anim | 2011 |
3,4-Methylenedioxymethamphetamine (MDMA) alters acute gammaherpesvirus burden and limits interleukin 27 responses in a mouse model of viral infection.
Topics: Animals; Dendritic Cells; Disease Models, Animal; Female; Gammaherpesvirinae; Hallucinogens; Herpesv | 2011 |
The effects of binge MDMA on acquisition and reversal learning in a radial-arm maze task.
Topics: Adaptation, Psychological; Analysis of Variance; Animals; Behavior, Animal; Cognition Disorders; Dis | 2011 |
Gender differences in hyperthermia and regional 5-HT and 5-HIAA depletion in the brain following MDMA administration in rats.
Topics: Animals; Brain; Disease Models, Animal; Female; Fever; Hydroxyindoleacetic Acid; Male; N-Methyl-3,4- | 2011 |
The effects of mirtazapine and fluoxetine on hyperthermia induced by 3,4-methylenedioxymethamphetamine (MDMA) in rats.
Topics: Animals; Antidepressive Agents, Tricyclic; Disease Models, Animal; Fever; Fluoxetine; Male; Mianseri | 2011 |
Chronic administration of THC prevents the behavioral effects of intermittent adolescent MDMA administration and attenuates MDMA-induced hyperthermia and neurotoxicity in rats.
Topics: Adrenergic Uptake Inhibitors; Age Factors; Analysis of Variance; Animals; Animals, Newborn; Behavior | 2011 |
Antidepressant-like effects of 3,4-methylenedioxymethamphetamine in an animal model of depression.
Topics: Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents; Brain; Central Nervous System Stimulan | 2011 |
3,4-methylenedioxymethamphetamine (ecstasy) decreases inflammation and airway reactivity in a murine model of asthma.
Topics: Animals; Asthma; Bone Marrow Cells; Bronchoalveolar Lavage Fluid; Cell Movement; Cytokines; Disease | 2012 |
Contribution of impulsivity and novelty-seeking to the acquisition and maintenance of MDMA self-administration.
Topics: Amphetamine-Related Disorders; Analysis of Variance; Animals; Disease Models, Animal; Drug-Seeking B | 2013 |
Cognitive impairments from developmental exposure to serotonergic drugs: citalopram and MDMA.
Topics: Animals; Animals, Newborn; Body Weight; Citalopram; Cognition Disorders; Disease Models, Animal; Fem | 2013 |
Clozapine reverses hyperthermia and sympathetically mediated cutaneous vasoconstriction induced by 3,4-methylenedioxymethamphetamine (ecstasy) in rabbits and rats.
Topics: Anesthesia; Animals; Antipsychotic Agents; Benzodiazepines; Body Temperature; Clozapine; Disease Mod | 2003 |
3,4-methylenedioxymethamphetamine (ecstasy) inhibits dyskinesia expression and normalizes motor activity in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated primates.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Antiparkinson Agents; Behavior, Animal; Calli | 2003 |
New treatment for Ecstasy-related hyperthermia.
Topics: Animals; Antipsychotic Agents; Benzodiazepines; Clozapine; Disease Models, Animal; Fever; Humans; N- | 2003 |
Dantrolene use in 3,4-methylenedioxymethamphetamine (ecstasy)-mediated hyperthermia.
Topics: Animals; Body Temperature; Dantrolene; Disease Models, Animal; Hallucinogens; Malignant Hyperthermia | 2004 |
MDMA-evoked changes in cerebral blood flow in living porcine brain: correlation with hyperthermia.
Topics: Animals; Brain; Cerebral Arteries; Cerebrovascular Circulation; Disease Models, Animal; Female; Feve | 2004 |
N-substituted piperazines abused by humans mimic the molecular mechanism of 3,4-methylenedioxymethamphetamine (MDMA, or 'Ecstasy').
Topics: Animals; Disease Models, Animal; Dopamine; Humans; Kinetics; Male; Microdialysis; N-Methyl-3,4-methy | 2005 |
3,4-Methylenedioxymethamphetamine counteracts akinesia enantioselectively in rat rotational behavior and catalepsy.
Topics: Adrenergic Uptake Inhibitors; Animals; Antiparkinson Agents; Behavior, Animal; Catalepsy; Denervatio | 2005 |
Up to speed.
Topics: Amphetamines; Animals; Brain; Disease Models, Animal; Mice; N-Methyl-3,4-methylenedioxyamphetamine; | 2005 |
Long-term voluntary consumption of MDMA and THC in rats is modified by individual and situational factors.
Topics: Animals; Behavior, Animal; Choice Behavior; Disease Models, Animal; Dronabinol; Hallucinogens; Male; | 2006 |
Association of caffeine to MDMA does not increase antinociception but potentiates adverse effects of this recreational drug.
Topics: Analgesics; Animals; Body Temperature; Brain; Caffeine; Central Nervous System Stimulants; Disease M | 2006 |
Protection against MDMA-induced dopaminergic neurotoxicity in mice by methyllycaconitine: involvement of nicotinic receptors.
Topics: Aconitine; Analysis of Variance; Animals; Cocaine; Disease Models, Animal; Dopamine; Dopamine Uptake | 2006 |
Attenuation of MDMA-induced hyperthermia by ethanol in rats depends on ambient temperature.
Topics: Analgesics, Non-Narcotic; Animals; Body Temperature; Disease Models, Animal; Ethanol; Fever; Male; N | 2007 |
DNA fragmentation and oxidative stress in the hippocampal formation: a bridge between 3,4-methylenedioxymethamphetamine (ecstasy) intake and long-lasting behavioral alterations.
Topics: Animals; Behavior, Animal; Cognition Disorders; Comet Assay; Disease Models, Animal; DNA Breaks, Dou | 2007 |
Changes in leptin, ghrelin, growth hormone and neuropeptide-Y after an acute model of MDMA and methamphetamine exposure in rats.
Topics: Adrenergic Uptake Inhibitors; Amphetamine-Related Disorders; Animals; Appetite; Body Weight; Disease | 2008 |
On the role of tyrosine and peripheral metabolism in 3,4-methylenedioxymethamphetamine-induced serotonin neurotoxicity in rats.
Topics: Analysis of Variance; Animals; Antimetabolites; Area Under Curve; Body Temperature; Brain; Catechols | 2008 |
Hair analysis for drugs of abuse. XVIII. 3,4-Methylenedioxymethamphetamine (MDMA) disposition in hair roots and use in identification of acute MDMA poisoning.
Topics: Acute Disease; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Hair; Hallucinogen | 1997 |
5-HT receptor knockout mice: pharmacological tools or models of psychiatric disorders.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aggression; Animals; Behavior, Animal; Cocaine; Disease Models, Anim | 1999 |
Effects of 3,4-methylenedioxy-methamphetamine (MDMA) on anxiety in mice tested in the light-dark box.
Topics: Animals; Anxiety; Disease Models, Animal; Exploratory Behavior; Hallucinogens; Light; Male; Mice; Mo | 2000 |
Prior exposure to methylenedioxyamphetamine (MDA) induces serotonergic loss and changes in spontaneous exploratory and amphetamine-induced behaviors in rats.
Topics: Animals; Brain; Dextroamphetamine; Disease Models, Animal; Exploratory Behavior; Hallucinogens; Inje | 2001 |
Involvement of free radicals in MDMA-induced neurotoxicity in mice.
Topics: Animals; Brain Chemistry; Catalase; Disease Models, Animal; Free Radicals; Gene Expression Regulatio | 2001 |