Page last updated: 2024-10-21

n-methyl-3,4-methylenedioxyamphetamine and Depression

n-methyl-3,4-methylenedioxyamphetamine has been researched along with Depression in 63 studies

N-Methyl-3,4-methylenedioxyamphetamine: An N-substituted amphetamine analog. It is a widely abused drug classified as a hallucinogen and causes marked, long-lasting changes in brain serotonergic systems. It is commonly referred to as MDMA or ecstasy.
3,4-methylenedioxymethamphetamine : A member of the class of benzodioxoles that is 1,3-benzodioxole substituted by a 2-(methylamino)propyl group at position 5.

Depression: Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders.

Research Excerpts

ExcerptRelevanceReference
"Fluoxetine treatment reversed MDMA-induced anxiety in the emergence test and depressive-like effects in the forced swim test, yet exhibited no effects on the social interaction test."5.32Chronic fluoxetine treatment partly attenuates the long-term anxiety and depressive symptoms induced by MDMA ('Ecstasy') in rats. ( Clemens, KJ; Cornish, JL; Gurtman, CG; Hunt, GE; Li, KM; McGregor, IS; Thompson, MR, 2004)
" Our experiments were designed to examine the effects of a concomitant administration of 3,4-methylenedioxy-methamphetamine (MDMA) and mephedrone on depression- and anxiety-like behaviors and cognitive processes in Swiss mice."3.85Acute behavioral effects of co-administration of mephedrone and MDMA in mice. ( Biała, G; Budzynska, B; Frankowska, M; Kaszubska, K; Michalak, A, 2017)
"Examine the severity of club drug dependence and perceived need for treatment, and further identify their determinants among a sample of club drug users in Shanghai, China."1.40Severity of club drug dependence and perceived need for treatment among a sample of adult club drug users in Shanghai, China. ( Detels, R; Ding, Y; Gao, M; He, N; Shoptaw, S, 2014)
"These results indicate that hyperthermia at the time of dosing with MDMA is not necessary to produce subsequent 5-HT depletion and anxiety in rats."1.32Increased anxiety and "depressive" symptoms months after MDMA ("ecstasy") in rats: drug-induced hyperthermia does not predict long-term outcomes. ( Blokland, A; Clemens, KJ; Cornish, JL; Gurtman, CG; Hunt, GE; Li, KM; McGregor, IS; Morley, KC, 2003)
"Fluoxetine treatment reversed MDMA-induced anxiety in the emergence test and depressive-like effects in the forced swim test, yet exhibited no effects on the social interaction test."1.32Chronic fluoxetine treatment partly attenuates the long-term anxiety and depressive symptoms induced by MDMA ('Ecstasy') in rats. ( Clemens, KJ; Cornish, JL; Gurtman, CG; Hunt, GE; Li, KM; McGregor, IS; Thompson, MR, 2004)
"Additionally, users that met DSM-IV substance use disorder criteria for lifetime MDMA abuse or dependence exhibited a number of additional deficits relative to those who did not meet these criteria."1.32Neurocognitive function in users of MDMA: the importance of clinically significant patterns of use. ( Hanson, KL; Luciana, M, 2004)
"The long-term use of the serotonin-releaser and uptake-inhibitor 3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") has been associated with memory impairments and increased liability to depressive mood and anxiety attacks."1.31No difference in brain activation during cognitive performance between ecstasy (3,4-methylenedioxymethamphetamine) users and control subjects: a [H2(15)O]-positron emission tomography study. ( Berthold, T; Buck, A; Gamma, A; Vollenweider, FX, 2001)

Research

Studies (63)

TimeframeStudies, this research(%)All Research%
pre-19901 (1.59)18.7374
1990's3 (4.76)18.2507
2000's33 (52.38)29.6817
2010's20 (31.75)24.3611
2020's6 (9.52)2.80

Authors

AuthorsStudies
Pantoni, MM1
Kim, JL1
Van Alstyne, KR1
Anagnostaras, SG1
Yang, KH1
Han, BH1
Palamar, JJ1
Haridy, R1
Nogrady, B1
Reardon, S1
Tullis, P1
Kuypers, KPC1
de la Torre, R1
Farre, M1
Xicota, L1
de Sousa Fernandes Perna, EB1
Theunissen, EL1
Ramaekers, JG2
Shih, JH1
Chiu, CH1
Ma, KH1
Huang, YS1
Shiue, CY1
Yeh, TY1
Kao, LT1
Lin, YY1
Li, IH1
George, AM1
Olesen, S1
Tait, RJ1
Ding, Y1
He, N1
Shoptaw, S1
Gao, M1
Detels, R1
Scott, RM3
Hides, L3
Allen, JS3
Lubman, DI3
Taurah, L1
Chandler, C1
Sanders, G1
Wetherell, MA1
Montgomery, C1
Turner, JJ1
Parrott, AC2
Goodwin, J1
Moore, DG1
Fulton, S1
Min, MO1
Singer, LT1
Fulde, GW1
Forster, SL1
Budzynska, B1
Michalak, A1
Frankowska, M1
Kaszubska, K1
Biała, G1
Green, A1
Marsden, C1
Fone, K1
Scheier, LM1
Ben Abdallah, A1
Inciardi, JA1
Copeland, J1
Cottler, LB1
Bedi, G1
Van Dam, NT1
Redman, J1
Daniulaityte, R1
Falck, RS2
Wang, J2
Carlson, RG2
Kelly, BC2
León, LA1
Landeira-Fernandez, J1
Cardenas, FP1
Bissette, G1
Schilt, T1
Koeter, MW1
Smal, JP1
Gouwetor, MN1
van den Brink, W2
Schmand, B1
Burke, R1
Jaehne, EJ1
Majumder, I1
Salem, A1
Irvine, RJ1
Matthews, AJ1
Bruno, R1
Nichols, D1
Fernando, T1
Gilbert, JD1
Carroll, CM1
Byard, RW1
Brière, FN1
Fallu, JS1
Janosz, M1
Pagani, LS1
Potter, A1
Downey, L1
Stough, C2
MacInnes, N2
Handley, SL2
Harding, GF2
Buchanan, T1
Scholey, AB1
Heffernan, T1
Ling, J1
Rodgers, J1
McGregor, IS2
Gurtman, CG2
Morley, KC1
Clemens, KJ2
Blokland, A1
Li, KM2
Cornish, JL2
Hunt, GE2
Verheyden, SL2
Henry, JA2
Curran, HV3
Thompson, MR1
Roiser, JP1
Sahakian, BJ1
Hanson, KL1
Luciana, M1
McCardle, K1
Luebbers, S1
Carter, JD1
Croft, RJ1
De Almeida, SP1
Silva, MT1
Diamond, GM1
Izzard, MC1
Kedar, T1
Hutlzer, A1
Mell, H1
Uys, JD1
Niesink, RJ1
Hoshi, R1
Pratt, H1
Mehta, S1
Bond, AJ1
Lamers, CT1
Bechara, A1
Rizzo, M1
Medina, KL1
Shear, PK1
Reid, LW1
Elifson, KW1
Sterk, CE1
Guillot, C1
Sessa, B1
Nutt, DJ1
Cohen, RS1
Pennings, EJ1
Konijn, KZ1
de Wolff, FA2
Gamma, A1
Buck, A1
Berthold, T1
Vollenweider, FX1
O'Leary, G1
Nargiso, J1
Weiss, RD1
Reneman, L1
Booij, J1
de Bruin, K1
Reitsma, JB1
Gunning, WB1
den Heeten, GJ1
Cole, JC1
Sumnall, HR1
Hadfield, J1
Calin, T1
Haddad, PM1
Strickland, P1
Anderson, I1
Deakin, JF1
Dursun, SM1
Ratzenböck, E1
Whitaker-Azmitia, PM1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Neurotoxicity of Ecstasy: Causality, Course and Clinical Relevance[NCT00235768]225 participants Observational2002-04-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

7 reviews available for n-methyl-3,4-methylenedioxyamphetamine and Depression

ArticleYear
MDMA and memory, addiction, and depression: dose-effect analysis.
    Psychopharmacology, 2022, Volume: 239, Issue:3

    Topics: Amnesia; Animals; Conditioning, Classical; Depression; Dose-Response Relationship, Drug; Fear; Mice;

2022
The impact of amphetamine-type stimulants on emergency services.
    Current opinion in psychiatry, 2015, Volume: 28, Issue:4

    Topics: Acute Disease; Aggression; Amphetamine; Amphetamine-Related Disorders; Anxiety; Central Nervous Syst

2015
Does Alzheimer's disease result from attempts at repair or protection after transient stress?
    Journal of Alzheimer's disease : JAD, 2009, Volume: 18, Issue:2

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Craniocerebral Tr

2009
Pharmacological aspects of the combined use of 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) and gamma-hydroxybutyric acid (GHB): a review of the literature.
    Drug and alcohol review, 2005, Volume: 24, Issue:4

    Topics: Anxiety; Body Temperature; Depression; Dopamine; Hallucinogens; Humans; Hydroxybutyrates; N-Methyl-3

2005
Is recreational ecstasy (MDMA) use associated with higher levels of depressive symptoms?
    Journal of psychoactive drugs, 2007, Volume: 39, Issue:1

    Topics: Affect; Depression; Humans; Illicit Drugs; N-Methyl-3,4-methylenedioxyamphetamine; Psychiatric Statu

2007
[Clinical and toxicologic aspects of the use of Ecstasy].
    Nederlands tijdschrift voor geneeskunde, 1998, Aug-29, Volume: 142, Issue:35

    Topics: Animals; Axons; Brain Chemistry; Depression; Female; Fever; Humans; Impulsive Behavior; Inappropriat

1998
3,4-methylenedioxymethamphetamine (MDMA): a review.
    Current psychiatry reports, 2001, Volume: 3, Issue:6

    Topics: Brain; Depression; Hallucinogens; Humans; Malignant Hyperthermia; N-Methyl-3,4-methylenedioxyampheta

2001

Trials

2 trials available for n-methyl-3,4-methylenedioxyamphetamine and Depression

ArticleYear
An investigation into the sub-acute effects of ecstasy on aggressive interpretative bias and aggressive mood - are there gender differences?
    Journal of psychopharmacology (Oxford, England), 2006, Volume: 20, Issue:2

    Topics: Adult; Affect; Aggression; Alcoholic Intoxication; Amphetamine-Related Disorders; Anxiety; Attention

2006
Cognitive function and mood in MDMA/THC users, THC users and non-drug using controls.
    Journal of psychopharmacology (Oxford, England), 2006, Volume: 20, Issue:2

    Topics: Adult; Amphetamine-Related Disorders; Anxiety; Cognition Disorders; Decision Making; Depression; Dis

2006

Other Studies

54 other studies available for n-methyl-3,4-methylenedioxyamphetamine and Depression

ArticleYear
Past-year hallucinogen use in relation to psychological distress, depression, and suicidality among US adults.
    Addictive behaviors, 2022, Volume: 132

    Topics: Adult; Depression; Depressive Disorder, Major; Hallucinogens; Humans; Lysergic Acid Diethylamide; N-

2022
Australia to prescribe MDMA and psilocybin for PTSD and depression in world first.
    Nature, 2023, Volume: 619, Issue:7969

    Topics: Australia; Depression; Drug Approval; Humans; N-Methyl-3,4-methylenedioxyamphetamine; Psilocybin; St

2023
Australia's approval of MDMA and psilocybin for PTSD and depression is premature, say critics.
    BMJ (Clinical research ed.), 2023, 07-11, Volume: 382

    Topics: Australia; Depression; Humans; N-Methyl-3,4-methylenedioxyamphetamine; Psilocybin; Stress Disorders,

2023
Psychedelic treatments are speeding towards approval - but no one knows how they work.
    Nature, 2023, Volume: 623, Issue:7985

    Topics: Depression; Hallucinogens; Humans; N-Methyl-3,4-methylenedioxyamphetamine; Psilocybin; Psychological

2023
How ecstasy and psilocybin are shaking up psychiatry.
    Nature, 2021, Volume: 589, Issue:7843

    Topics: Animals; Certification; Clinical Trials as Topic; Depression; Depressive Disorder, Treatment-Resista

2021
Depressive mood ratings are reduced by MDMA in female polydrug ecstasy users homozygous for the l-allele of the serotonin transporter.
    Scientific reports, 2018, 01-18, Volume: 8, Issue:1

    Topics: Adolescent; Adult; Affect; Alleles; Depression; Drug Users; Female; Genetic Predisposition to Diseas

2018
Autophagy inhibition plays a protective role against 3, 4-methylenedioxymethamphetamine (MDMA)-induced loss of serotonin transporters and depressive-like behaviors in rats.
    Pharmacological research, 2019, Volume: 142

    Topics: Adenine; Animals; Autophagy; Behavior, Animal; Brain; Depression; Male; N-Methyl-3,4-methylenedioxya

2019
Ecstasy use and depression: a 4-year longitudinal study among an Australian general community sample.
    Psychopharmacology, 2013, Volume: 229, Issue:4

    Topics: Adult; Australia; Depression; Female; Humans; Longitudinal Studies; Male; Multivariate Analysis; N-M

2013
Severity of club drug dependence and perceived need for treatment among a sample of adult club drug users in Shanghai, China.
    Social psychiatry and psychiatric epidemiology, 2014, Volume: 49, Issue:3

    Topics: Adolescent; Adult; China; Depression; Drug Users; Female; Humans; Illicit Drugs; Male; Motivation; N

2014
Coping style and ecstasy use motives as predictors of current mood symptoms in ecstasy users.
    Addictive behaviors, 2013, Volume: 38, Issue:10

    Topics: Adaptation, Psychological; Adolescent; Adult; Affective Symptoms; Anxiety; Australia; Child; Cross-S

2013
Depression, impulsiveness, sleep, and memory in past and present polydrug users of 3,4-methylenedioxymethamphetamine (MDMA, ecstasy).
    Psychopharmacology, 2014, Volume: 231, Issue:4

    Topics: Adolescent; Adult; Alcohol-Related Disorders; Amphetamine-Related Disorders; Attitude to Health; Dep

2014
Basal functioning of the hypothalamic-pituitary-adrenal (HPA) axis and psychological distress in recreational ecstasy polydrug users.
    Psychopharmacology, 2014, Volume: 231, Issue:7

    Topics: Anxiety; Case-Control Studies; Circadian Rhythm; Depression; Drug Users; Female; Humans; Hydrocortis

2014
Psychiatric profiles of mothers who take Ecstasy/MDMA during pregnancy: reduced depression 1 year after giving birth and quitting Ecstasy.
    Journal of psychopharmacology (Oxford, England), 2014, Volume: 28, Issue:1

    Topics: Adult; Case-Control Studies; Depression; Drug Users; Female; Health Status; Humans; Illicit Drugs; M

2014
Acute behavioral effects of co-administration of mephedrone and MDMA in mice.
    Pharmacological reports : PR, 2017, Volume: 69, Issue:2

    Topics: Animals; Antidepressive Agents; Anxiety; Cognition; Depression; Disease Models, Animal; Drug Interac

2017
MDMA as a clinical tool: a note of caution. A response to Sessa and Nutt.
    Journal of psychopharmacology (Oxford, England), 2008, Volume: 22, Issue:8

    Topics: Animals; Depression; Dopamine; Electroconvulsive Therapy; Humans; N-Methyl-3,4-methylenedioxyampheta

2008
Tri-city study of Ecstasy use problems: a latent class analysis.
    Drug and alcohol dependence, 2008, Dec-01, Volume: 98, Issue:3

    Topics: Adult; Amphetamine-Related Disorders; Depression; Family; Female; Hallucinogens; Humans; Logistic Mo

2008
Ecstasy (MDMA) and high prevalence psychiatric symptomatology: somatic anxiety symptoms are associated with polydrug, not ecstasy, use.
    Journal of psychopharmacology (Oxford, England), 2010, Volume: 24, Issue:2

    Topics: Adolescent; Adult; Anxiety; Depression; Female; Hallucinogens; Humans; Male; Marijuana Abuse; Multiv

2010
Illicit use of pharmaceutical opioids among young polydrug users in Ohio.
    Addictive behaviors, 2009, Volume: 34, Issue:8

    Topics: Adolescent; Adult; Amphetamine-Related Disorders; Analgesics, Opioid; Depression; Diagnosis, Dual (P

2009
Mediating MDMA-related harm: preloading and post-loading among Ecstasy-using youth.
    Journal of psychoactive drugs, 2009, Volume: 41, Issue:1

    Topics: Adolescent; Adult; Amphetamine-Related Disorders; Antidepressive Agents; Antidepressive Agents, Seco

2009
Effects of chronic intracerebroventricular 3,4-methylenedioxy-N-methamphetamine (MDMA) or fluoxetine on the active avoidance test in rats with or without exposure to mild chronic stress.
    Behavioural brain research, 2009, Dec-14, Volume: 205, Issue:1

    Topics: Analysis of Variance; Animals; Avoidance Learning; Chronic Disease; Depression; Disease Models, Anim

2009
Long-term neuropsychological effects of ecstasy in middle-aged ecstasy/polydrug users.
    Psychopharmacology, 2010, Volume: 207, Issue:4

    Topics: Adult; Age Factors; Attention; Cross-Sectional Studies; Depression; Female; Hallucinogens; Humans; I

2010
Depressive and anxiety symptomatology in ecstasy users: the relative contribution of genes, trauma, life stress and drug use.
    Psychopharmacology, 2010, Volume: 209, Issue:1

    Topics: Adolescent; Adult; Affect; Anxiety; Depression; Female; Hallucinogens; Humans; Male; N-Methyl-3,4-me

2010
Increased effects of 3,4-methylenedioxymethamphetamine (ecstasy) in a rat model of depression.
    Addiction biology, 2011, Volume: 16, Issue:1

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Arousal; Body Temperature Regulation; Brain; Cerebral Corte

2011
An investigation of factors associated with depressive symptoms among a sample of regular ecstasy consumers.
    Neuropsychobiology, 2010, Volume: 61, Issue:4

    Topics: Adolescent; Adult; Chi-Square Distribution; Depression; Female; Humans; Male; N-Methyl-3,4-methylene

2010
Legal highs: the dark side of medicinal chemistry.
    Nature, 2011, Jan-06, Volume: 469, Issue:7328

    Topics: Amphetamines; Animals; Depression; Designer Drugs; Drug Design; Electronic Mail; Hallucinogens; Huma

2011
Ecstasy and suicide.
    Journal of forensic sciences, 2012, Volume: 57, Issue:4

    Topics: Adolescent; Depression; Female; Forensic Pathology; Forensic Toxicology; Hallucinogens; Humans; Live

2012
Prospective associations between meth/amphetamine (speed) and MDMA (ecstasy) use and depressive symptoms in secondary school students.
    Journal of epidemiology and community health, 2012, Volume: 66, Issue:11

    Topics: Adolescent; Amphetamine-Related Disorders; Central Nervous System Stimulants; Depression; Female; Hu

2012
Subacute effects of ecstasy on mood: an exploration of associated risk factors.
    Journal of psychopharmacology (Oxford, England), 2013, Volume: 27, Issue:1

    Topics: Adult; Affect; Anxiety; Depression; Female; Follow-Up Studies; Humans; Male; Mental Disorders; N-Met

2013
Cognitive function in ecstasy naive abstinent drug dependants and MDMA users.
    Current drug abuse reviews, 2013, Volume: 6, Issue:1

    Topics: Adult; Affect; Case-Control Studies; Cognition; Depression; Drug Users; Female; Humans; Illicit Drug

2013
The BDI of the beholder: an eye to experimental design.
    Journal of psychopharmacology (Oxford, England), 2002, Volume: 16, Issue:3

    Topics: Depression; Humans; N-Methyl-3,4-methylenedioxyamphetamine; Personality Inventory; Psychometrics; Ra

2002
Ecstasy/MDMA attributed problems reported by novice, moderate and heavy recreational users.
    Human psychopharmacology, 2002, Volume: 17, Issue:6

    Topics: Anxiety; Depression; Humans; Illicit Drugs; Internet; Memory Disorders; N-Methyl-3,4-methylenedioxya

2002
Increased anxiety and "depressive" symptoms months after MDMA ("ecstasy") in rats: drug-induced hyperthermia does not predict long-term outcomes.
    Psychopharmacology, 2003, Volume: 168, Issue:4

    Topics: Amygdala; Animals; Anxiety; Biogenic Monoamines; Cognition; Corpus Striatum; Depression; Fever; Hipp

2003
Acute, sub-acute and long-term subjective consequences of 'ecstasy' (MDMA) consumption in 430 regular users.
    Human psychopharmacology, 2003, Volume: 18, Issue:7

    Topics: Adolescent; Adult; Amphetamine-Related Disorders; Attention; Depression; England; Female; Hallucinog

2003
Chronic fluoxetine treatment partly attenuates the long-term anxiety and depressive symptoms induced by MDMA ('Ecstasy') in rats.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2004, Volume: 29, Issue:4

    Topics: Animals; Antidepressive Agents, Second-Generation; Anxiety; Body Fluids; Body Temperature; Body Weig

2004
Relationship between ecstasy use and depression: a study controlling for poly-drug use.
    Psychopharmacology, 2004, Volume: 173, Issue:3-4

    Topics: Adult; Attention; Bias; Depression; Emotions; Female; Humans; Illicit Drugs; Male; N-Methyl-3,4-meth

2004
Neurocognitive function in users of MDMA: the importance of clinically significant patterns of use.
    Psychological medicine, 2004, Volume: 34, Issue:2

    Topics: Adolescent; Adult; Brain; Cognition Disorders; Depression; Diagnostic and Statistical Manual of Ment

2004
Chronic MDMA (ecstasy) use, cognition and mood.
    Psychopharmacology, 2004, Volume: 173, Issue:3-4

    Topics: Adult; Affect; Cognition; Depression; Female; Humans; Male; N-Methyl-3,4-methylenedioxyamphetamine;

2004
Characteristics of ecstasy users in Sãio Paulo, Brazil.
    Substance use & misuse, 2005, Volume: 40, Issue:3

    Topics: Adult; Anxiety; Brazil; Catchment Area, Health; Depression; Disruptive, Impulse Control, and Conduct

2005
Psychological symptoms and drug use severity among Israeli adolescents presenting for outpatient drug abuse treatment.
    Journal of adolescence, 2005, Volume: 28, Issue:4

    Topics: Adolescent; Ambulatory Care; Attention Deficit and Disruptive Behavior Disorders; Depression; Female

2005
Conceptions of risk in the lives of club drug-using youth.
    Substance use & misuse, 2005, Volume: 40, Issue:9-10

    Topics: Adolescent; Adult; Anthropology, Cultural; Attitude to Health; Depression; Female; Hallucinogens; He

2005
Anxiety, depression, and behavioral symptoms of executive dysfunction in ecstasy users: contributions of polydrug use.
    Drug and alcohol dependence, 2007, Mar-16, Volume: 87, Issue:2-3

    Topics: Affect; Anxiety; Behavioral Symptoms; Depression; Female; Humans; Male; N-Methyl-3,4-methylenedioxya

2007
Hug drug or thug drug? Ecstasy use and aggressive behavior.
    Violence and victims, 2007, Volume: 22, Issue:1

    Topics: Adult; Affect; Aggression; Amphetamine-Related Disorders; Anxiety; Attention; Concept Formation; Dep

2007
MDMA, politics and medical research: have we thrown the baby out with the bathwater?
    Journal of psychopharmacology (Oxford, England), 2007, Volume: 21, Issue:8

    Topics: Affect; Biomedical Research; Depression; Humans; Legislation, Drug; N-Methyl-3,4-methylenedioxyamphe

2007
Depressive symptomatology in young adults with a history of MDMA use: a longitudinal analysis.
    Journal of psychopharmacology (Oxford, England), 2008, Volume: 22, Issue:1

    Topics: Adolescent; Adult; Amphetamine-Related Disorders; Depression; Female; Humans; Longitudinal Studies;

2008
Ecstasy and serotonin depletion.
    Lancet (London, England), 1996, Mar-23, Volume: 347, Issue:9004

    Topics: Animals; Depression; Hallucinogens; Humans; Illicit Drugs; N-Methyl-3,4-methylenedioxyamphetamine; T

1996
Subjective reports on the effects of the MDMA ('ecstasy') experience in humans.
    Progress in neuro-psychopharmacology & biological psychiatry, 1995, Volume: 19, Issue:7

    Topics: Adolescent; Adult; Anxiety; Behavior; Depression; Female; Humans; Male; N-Methyl-3,4-methylenedioxya

1995
No difference in brain activation during cognitive performance between ecstasy (3,4-methylenedioxymethamphetamine) users and control subjects: a [H2(15)O]-positron emission tomography study.
    Journal of clinical psychopharmacology, 2001, Volume: 21, Issue:1

    Topics: Adult; Affect; Age Factors; Arousal; Brain; Cognition; Depression; Female; Hallucinogens; Humans; Ma

2001
Former chronic methylenedioxymethamphetamine (MDMA or ecstasy) users report mild depressive symptoms.
    Journal of psychopharmacology (Oxford, England), 2001, Volume: 15, Issue:3

    Topics: Adult; Depression; Female; Humans; Internal-External Control; Life Change Events; Male; Motivation;

2001
Effects of dose, sex, and long-term abstention from use on toxic effects of MDMA (ecstasy) on brain serotonin neurons.
    Lancet (London, England), 2001, Dec-01, Volume: 358, Issue:9296

    Topics: Adult; Binding Sites; Brain; Case-Control Studies; Depression; Dose-Response Relationship, Drug; Fem

2001
The BDI of the beholder.
    Journal of psychopharmacology (Oxford, England), 2002, Volume: 16, Issue:1

    Topics: Depression; Hallucinogens; Humans; N-Methyl-3,4-methylenedioxyamphetamine; Psychiatric Status Rating

2002
Sub-acute effects of MDMA (+/-3,4-methylenedioxymethamphetamine, "ecstasy") on mood: evidence of gender differences.
    Psychopharmacology, 2002, Volume: 161, Issue:1

    Topics: Adolescent; Adult; Affect; Aggression; Depression; Female; Humans; Male; N-Methyl-3,4-methylenedioxy

2002
Effects of MDMA (ecstasy) use and abstention on serotonin neurons.
    Lancet (London, England), 2002, May-04, Volume: 359, Issue:9317

    Topics: Adult; Binding Sites; Brain; Depression; Dose-Response Relationship, Drug; Female; Humans; Male; N-M

2002
Effects of MDMA (ecstasy) use and abstention on serotonin neurons.
    Lancet (London, England), 2002, May-04, Volume: 359, Issue:9317

    Topics: Adult; Binding Sites; Brain; Depression; Dose-Response Relationship, Drug; Female; Humans; Male; N-M

2002
Depression to ecstasy. The Neuropharmacology of Serotonin sponsored by the New York Academy of Sciences, New York, NY, USA, July 10-13, 1989.
    The New biologist, 1989, Volume: 1, Issue:2

    Topics: 3,4-Methylenedioxyamphetamine; Animals; Brain Mapping; Depression; Humans; Mental Disorders; Migrain

1989