Compounds > n-methyl-3,4-methylenedioxyamphetamine
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n-methyl-3,4-methylenedioxyamphetamine and Depression, Endogenous

n-methyl-3,4-methylenedioxyamphetamine has been researched along with Depression, Endogenous in 31 studies

N-Methyl-3,4-methylenedioxyamphetamine: An N-substituted amphetamine analog. It is a widely abused drug classified as a hallucinogen and causes marked, long-lasting changes in brain serotonergic systems. It is commonly referred to as MDMA or ecstasy.
3,4-methylenedioxymethamphetamine : A member of the class of benzodioxoles that is 1,3-benzodioxole substituted by a 2-(methylamino)propyl group at position 5.

Research Excerpts

ExcerptRelevanceReference
"Ecstasy and cocaine abusers exhibited higher TAS-20 and BDI-13 scores and lower levels of emotional awareness than non-drug users."1.38[Emotion regulation among psychostimulants drug users at techno parties]. ( Lillaz, C; Varescon, I, 2012)
" Problematic ecstasy users reported significantly higher levels of ecstasy use, including lifetime consumption, average dosage and binge consumption compared to non-problematic ecstasy users."1.33Problematic versus non-problematic ecstasy/MDMA use: the influence of drug usage patterns and pre-existing psychiatric factors. ( Parrott, AC; Soar, K; Turner, JJ, 2006)

Research

Studies (31)

TimeframeStudies, this research(%)All Research%
pre-19901 (3.23)18.7374
1990's5 (16.13)18.2507
2000's16 (51.61)29.6817
2010's9 (29.03)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Hanck, L1
Schellekens, AF1
McCann, M1
Higgins, K1
Perra, O1
McCartan, C1
McLaughlin, A1
Shih, JH1
Ma, KH1
Chen, CF1
Cheng, CY1
Pao, LH1
Weng, SJ1
Huang, YS1
Shiue, CY1
Yeh, MK1
Li, IH1
Chen, CY1
Lin, KM1
Leung, KS1
Ben Abdallah, A1
Copeland, J1
Cottler, LB1
van Donkelaar, EL1
Kelly, PA1
Dawson, N1
Blokland, A1
Prickaerts, J1
Steinbusch, HW1
Ferrington, L1
Ayala, ME1
Fogger, SA1
Majumder, I2
White, JM2
Irvine, RJ2
Lillaz, C1
Varescon, I1
Gerra, G1
Zaimovic, A1
Moi, G1
Giusti, F1
Gardini, S1
Delsignore, R1
Laviola, G1
Macchia, T1
Brambilla, F1
Harley, CW1
Milani, RM1
Parrott, AC3
Turner, JJ2
Fox, HC2
Soar, K2
Sumnall, HR1
Cole, JC1
Roiser, JP1
Cook, LJ1
Cooper, JD1
Rubinsztein, DC1
Sahakian, BJ1
Falck, RS2
Wang, J2
Carlson, RG2
Siegal, HA2
Huizink, AC1
Ferdinand, RF1
van der Ende, J1
Verhulst, FC1
de Win, MM1
Schilt, T1
Reneman, L1
Vervaeke, H1
Jager, G1
Dijkink, S1
Booij, J1
van den Brink, W1
Guillot, C1
Greenway, D1
Poikolainen, K1
Alati, R1
Kinner, SA1
Hayatbakhsh, MR1
Mamun, AA1
Najman, JM1
Williams, GM1
Cohen, RS1
Teggin, AF1
Krystal, JH1
Price, LH1
Opsahl, C1
Ricaurte, GA2
Heninger, GR1
Benazzi, F1
Mazzoli, M1
McCann, UD1
Whitaker-Azmitia, PM1
Aronson, TA1

Reviews

2 reviews available for n-methyl-3,4-methylenedioxyamphetamine and Depression, Endogenous

ArticleYear
Health consequences of illegal drug use.
    Current opinion in psychiatry, 2009, Volume: 22, Issue:3

    Topics: Amphetamine; Depressive Disorder; Health Status; Hepatitis C; Humans; Illicit Drugs; Marijuana Abuse

2009
Self-reported depressive symptomatology in community samples of polysubstance misusers who report Ecstasy use: a meta-analysis.
    Journal of psychopharmacology (Oxford, England), 2005, Volume: 19, Issue:1

    Topics: Depressive Disorder; Humans; N-Methyl-3,4-methylenedioxyamphetamine; Population Surveillance; Psychi

2005

Trials

1 trial available for n-methyl-3,4-methylenedioxyamphetamine and Depression, Endogenous

ArticleYear
Effects of (+/-) 3,4-methylene-dioxymethamphetamine (ecstasy) on dopamine system function in humans.
    Behavioural brain research, 2002, Aug-21, Volume: 134, Issue:1-2

    Topics: Adolescent; Adult; Aggression; Bromocriptine; Depressive Disorder; Dopamine; Dopamine Agonists; Dopa

2002

Other Studies

28 other studies available for n-methyl-3,4-methylenedioxyamphetamine and Depression, Endogenous

ArticleYear
[Hallucinogen persisting perception disorder after ecstasy use].
    Nederlands tijdschrift voor geneeskunde, 2013, Volume: 157, Issue:24

    Topics: Anxiety Disorders; Citalopram; Depressive Disorder; Hallucinations; Hallucinogens; Humans; Male; N-M

2013
Adolescent ecstasy use and depression: cause and effect, or two outcomes of home environment?
    European journal of public health, 2014, Volume: 24, Issue:5

    Topics: Adolescent; Adolescent Behavior; Amphetamine-Related Disorders; Causality; Cohort Studies; Depressiv

2014
Evaluation of brain SERT occupancy by resveratrol against MDMA-induced neurobiological and behavioral changes in rats: A 4-[¹⁸F]-ADAM/small-animal PET study.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2016, Volume: 26, Issue:1

    Topics: Animals; Benzylamines; Brain; Brain Mapping; Corticosterone; Depressive Disorder; Dose-Response Rela

2016
Modifiable risk factors of ecstasy use: risk perception, current dependence, perceived control, and depression.
    Addictive behaviors, 2010, Volume: 35, Issue:3

    Topics: Adolescent; Adult; Depressive Disorder; Female; Florida; Hallucinogens; Humans; Male; Middle Aged; M

2010
Acute tryptophan depletion potentiates 3,4-methylenedioxymethamphetamine-induced cerebrovascular hyperperfusion in adult male Wistar rats.
    Journal of neuroscience research, 2010, May-15, Volume: 88, Issue:7

    Topics: Animals; Binding, Competitive; Brain; Cerebral Arteries; Cerebrovascular Circulation; Cerebrovascula

2010
Brain serotonin, psychoactive drugs, and effects on reproduction.
    Central nervous system agents in medicinal chemistry, 2009, Volume: 9, Issue:4

    Topics: Affect; Amphetamine-Related Disorders; Animals; Biological Clocks; Brain; Cognition Disorders; Depre

2009
Update on ecstasy.
    Journal of psychosocial nursing and mental health services, 2011, Volume: 49, Issue:4

    Topics: Adolescent; Adrenergic Uptake Inhibitors; Amphetamine-Related Disorders; Anxiety Disorders; Cognitio

2011
Antidepressant-like effects of 3,4-methylenedioxymethamphetamine in an animal model of depression.
    Behavioural pharmacology, 2011, Volume: 22, Issue:8

    Topics: Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents; Brain; Central Nervous System Stimulan

2011
Antidepressant-like effects of ecstasy in subjects with a predisposition to depression.
    Addictive behaviors, 2012, Volume: 37, Issue:10

    Topics: Affect; Case-Control Studies; Depressive Disorder; Female; Humans; Male; N-Methyl-3,4-methylenedioxy

2012
[Emotion regulation among psychostimulants drug users at techno parties].
    L'Encephale, 2012, Volume: 38, Issue:5

    Topics: Affective Symptoms; Awareness; Central Nervous System Stimulants; Cocaine-Related Disorders; Comorbi

2012
Norepinephrine and serotonin axonal dynamics and clinical depression: a commentary on the interaction between serotonergic and noradrenergic axons during axonal regeneration.
    Experimental neurology, 2003, Volume: 184, Issue:1

    Topics: Animals; Antidepressive Agents; Axons; Depressive Disorder; Hallucinogens; Humans; N-Methyl-3,4-meth

2003
Gender differences in self-reported anxiety, depression, and somatization among ecstasy/MDMA polydrug users, alcohol/tobacco users, and nondrug users.
    Addictive behaviors, 2004, Volume: 29, Issue:5

    Topics: Adult; Amphetamine-Related Disorders; Analysis of Variance; Anxiety Disorders; Depressive Disorder;

2004
Persistent neuropsychological problems after 7 years of abstinence from recreational Ecstasy (MDMA): a case study.
    Psychological reports, 2004, Volume: 95, Issue:1

    Topics: Adrenergic Uptake Inhibitors; Adult; Depressive Disorder; Erectile Dysfunction; Follow-Up Studies; H

2004
Association of a functional polymorphism in the serotonin transporter gene with abnormal emotional processing in ecstasy users.
    The American journal of psychiatry, 2005, Volume: 162, Issue:3

    Topics: Adult; Affective Symptoms; Depressive Disorder; Diagnosis, Dual (Psychiatry); Female; Genotype; Huma

2005
Prevalence and correlates of current depressive symptomatology among a community sample of MDMA users in Ohio.
    Addictive behaviors, 2006, Volume: 31, Issue:1

    Topics: Adult; Cross-Sectional Studies; Depressive Disorder; Female; Hallucinogens; Humans; Logistic Models;

2006
Symptoms of anxiety and depression in childhood and use of MDMA: prospective, population based study.
    BMJ (Clinical research ed.), 2006, Apr-08, Volume: 332, Issue:7545

    Topics: Adolescent; Adult; Anxiety Disorders; Child; Child, Preschool; Depressive Disorder; Female; Hallucin

2006
Ecstasy use and self-reported depression, impulsivity, and sensation seeking: a prospective cohort study.
    Journal of psychopharmacology (Oxford, England), 2006, Volume: 20, Issue:2

    Topics: Adolescent; Adult; Amphetamine-Related Disorders; Comorbidity; Depressive Disorder; Exploratory Beha

2006
Recreational ecstasy use and depression.
    Journal of psychopharmacology (Oxford, England), 2006, Volume: 20, Issue:3

    Topics: Adolescent; Adult; Amphetamine-Related Disorders; Depressive Disorder; Female; Humans; Illicit Drugs

2006
Problematic versus non-problematic ecstasy/MDMA use: the influence of drug usage patterns and pre-existing psychiatric factors.
    Journal of psychopharmacology (Oxford, England), 2006, Volume: 20, Issue:3

    Topics: Adolescent; Adult; Amphetamine-Related Disorders; Anxiety Disorders; Comorbidity; Depressive Disorde

2006
Ecstasy and the antecedents of illicit drug use.
    BMJ (Clinical research ed.), 2006, Apr-08, Volume: 332, Issue:7545

    Topics: Anxiety Disorders; Depressive Disorder; Hallucinogens; Humans; N-Methyl-3,4-methylenedioxyamphetamin

2006
Psychiatric disorders and their correlates among young adult MDMA users in Ohio.
    Journal of psychoactive drugs, 2006, Volume: 38, Issue:1

    Topics: Adolescent; Adult; Analysis of Variance; Depressive Disorder; Female; Humans; Interviews as Topic; M

2006
Pathways to ecstasy use in young adults: anxiety, depression or behavioural deviance?
    Drug and alcohol dependence, 2008, Jan-01, Volume: 92, Issue:1-3

    Topics: Adolescent; Adolescent Behavior; Adult; Analysis of Variance; Anxiety; Child; Child Behavior Disorde

2008
Adverse symptomatology and suicide associated with the use of methylenedioxymethamphetamine (MDMA; "Ecstasy").
    Biological psychiatry, 1996, May-01, Volume: 39, Issue:9

    Topics: Adolescent; Adult; Combined Modality Therapy; Depressive Disorder; Female; Hallucinogens; Humans; Ma

1996
Ecstasy--a dangerous drug.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1992, Apr-18, Volume: 81, Issue:8

    Topics: 3,4-Methylenedioxyamphetamine; Adult; Amitriptyline; Brain Ischemia; Depressive Disorder; Designer D

1992
Chronic 3,4-methylenedioxymethamphetamine (MDMA) use: effects on mood and neuropsychological function?
    The American journal of drug and alcohol abuse, 1992, Volume: 18, Issue:3

    Topics: 3,4-Methylenedioxyamphetamine; Adult; Cognition Disorders; Depressive Disorder; Female; Humans; Male

1992
Psychiatric illness associated with "ecstasy".
    Lancet (London, England), 1991, Dec-14, Volume: 338, Issue:8781

    Topics: 3,4-Methylenedioxyamphetamine; Adult; Depressive Disorder; Humans; Infant; Male; N-Methyl-3,4-methyl

1991
Lasting neuropsychiatric sequelae of (+-)methylenedioxymethamphetamine ('ecstasy') in recreational users.
    Journal of clinical psychopharmacology, 1991, Volume: 11, Issue:5

    Topics: 3,4-Methylenedioxyamphetamine; Adolescent; Adult; Anxiety Disorders; Depressive Disorder; Female; Fo

1991
"Ecstasy" (MDMA)-induced panic.
    The American journal of psychiatry, 1989, Volume: 146, Issue:1

    Topics: 3,4-Methylenedioxyamphetamine; Adult; Amphetamines; Depressive Disorder; Fear; Female; Humans; Male;

1989