Page last updated: 2024-10-21

n-methyl-3,4-methylenedioxyamphetamine and Cognition Disorders

n-methyl-3,4-methylenedioxyamphetamine has been researched along with Cognition Disorders in 95 studies

N-Methyl-3,4-methylenedioxyamphetamine: An N-substituted amphetamine analog. It is a widely abused drug classified as a hallucinogen and causes marked, long-lasting changes in brain serotonergic systems. It is commonly referred to as MDMA or ecstasy.
3,4-methylenedioxymethamphetamine : A member of the class of benzodioxoles that is 1,3-benzodioxole substituted by a 2-(methylamino)propyl group at position 5.

Cognition Disorders: Disorders characterized by disturbances in mental processes related to learning, thinking, reasoning, and judgment.

Research Excerpts

ExcerptRelevanceReference
"Little is known about the effect of stimulant use (amphetamines, cocaine, ecstasy) on cognitive functioning in schizophrenia patients."3.80Cognitive functioning associated with stimulant use in patients with non-affective psychosis, their unaffected siblings and healthy controls. ( Meijer, CJ; Meijer, JH; van den Brink, W; van der Meer, FJ; Velthorst, E, 2014)
" Thus, the current state of research does not allow for the conclusion that long-term use of MDMA affects decision-making behavior in general."2.55Decision-making in chronic ecstasy users: a systematic review. ( Betzler, F; Romanczuk-Seiferth, N; Viohl, L, 2017)
"There is a higher frequency of both psychiatric illness and cognitive impairment among ecstasy users."2.43[Psychiatric and cognitive long-term effects of ecstasy]. ( Bachs, L; Bramness, JG; Høiseth, G; Løvåsdal, Ø; Titze, TK, 2006)
"Conventional wisdom, and even well-reasoned theoretical mechanisms, suggests that the chronic use of psychoactive substances would impair cognitive functioning of individuals."2.42Cognitive impairment in substance abuse. ( Cellucci, T; Hedt, J; Jarchow, A; Vik, PW, 2004)
" The possibility that some of these psychological problems are caused by ecstasy-induced neurotoxicity is supported by preclinical evidence of MDMA-induced neurotoxicity and behavioural deficits, evidence of depleted serotonin in heavy ecstasy users, and by dose-response relationships between the extent of exposure to ecstasy and the severity of cognitive impairments."2.41Ecstasy (MDMA): a review of its possible persistent psychological effects. ( Morgan, MJ, 2000)
" This case report indicates that even non-chronic MDMA use may cause subacute toxic encephalopathy in which the clinical evolution is paralleled by neuroimaging changes in specific cerebral areas."1.35Hippocampal remodelling after MDMA neurotoxicity: a single case study. ( Amistà, P; Battaglia, M; Bertagnoni, GE; Carollo, C; Costanzo, R; Lupi, A; Martinuzzi, A; Nifosì, F; Perini, G; Toffanin, T; Vestri, A, 2009)
"During sleep deprivation, MDMA users, but not controls, became increasingly impulsive, performing more rapidly at the expense of accuracy on tasks of working and short-term memory."1.35Sleep deprivation differentially impairs cognitive performance in abstinent methylenedioxymethamphetamine ("Ecstasy") users. ( McCann, UD; Ricaurte, GA; Sgambati, FP; Wilson, MJ, 2009)
"Additionally, users that met DSM-IV substance use disorder criteria for lifetime MDMA abuse or dependence exhibited a number of additional deficits relative to those who did not meet these criteria."1.32Neurocognitive function in users of MDMA: the importance of clinically significant patterns of use. ( Hanson, KL; Luciana, M, 2004)
" To test for a possible dose-response effect, we also performed a median split of 12 moderate MDMA users (22-50 lifetime uses) and 11 heavy users (60-450 uses), and compared these subgroups with non-users."1.32Residual neuropsychological effects of illicit 3,4-methylenedioxymethamphetamine (MDMA) in individuals with minimal exposure to other drugs. ( Barry, S; Halpern, JH; Hudson, JI; Pope, HG; Sherwood, AR; Yurgelun-Todd, D, 2004)

Research

Studies (95)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (2.11)18.2507
2000's66 (69.47)29.6817
2010's27 (28.42)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Roberts, CA4
Quednow, BB3
Montgomery, C8
Parrott, AC10
Valverde, O1
Rodríguez-Árias, M2
Fairclough, SH1
McGlone, FP1
Fisk, JE6
van der Meer, FJ1
Meijer, JH1
Meijer, CJ1
van den Brink, W3
Velthorst, E1
Pázmány, P1
Petschner, P1
Ádori, C1
Kirilly, E1
Andó, DR1
Balogh, B1
Gyöngyösi, N1
Bagdy, G1
Ruis, C1
Postma, A1
Bouvy, W1
van der Ham, I1
Costa, G1
Simola, N1
Morelli, M1
Wetherell, MA1
Garg, A1
Kapoor, S1
Goel, M1
Chopra, S1
Chopra, M1
Kapoor, A1
McCann, UD2
Behera, C1
Downey, LA1
Sands, H1
Jones, L1
Clow, A1
Evans, P1
Stalder, T1
García-Pardo, MP1
Roger-Sánchez, C1
Miñarro, J1
Aguilar, MA1
Betzler, F1
Viohl, L1
Romanczuk-Seiferth, N1
Nifosì, F1
Martinuzzi, A1
Toffanin, T1
Costanzo, R1
Vestri, A1
Battaglia, M1
Bertagnoni, GE1
Lupi, A1
Amistà, P1
Carollo, C1
Perini, G1
Krebs, TS1
Johansen, PØ1
Jerome, L1
Halpern, JH3
Pompili, M1
Lester, D1
Girardi, P1
Tatarelli, R1
Wilson, MJ1
Sgambati, FP1
Ricaurte, GA2
Piechatzek, M1
Indlekofer, F1
Daamen, M1
Glasmacher, C1
Lieb, R1
Pfister, H1
Tucha, O1
Lange, KW1
Wittchen, HU1
Schütz, CG1
Ayala, ME1
Plaza-Zabala, A1
Berrendero, F1
Suarez, J1
Bermudez-Silva, FJ1
Fernandez-Espejo, E1
Serrano, A1
Pavon, FJ1
Parsons, LH1
De Fonseca, FR1
Maldonado, R1
Robledo, P1
Hadjiefthyvoulou, F2
Bridges, N2
Dastrup, E1
Lees, MN1
Bechara, A2
Dawson, JD1
Rizzo, M2
Hanson, KL3
Luciana, M3
Blagrove, M1
Seddon, J1
George, S1
Stickgold, R1
Walker, MP1
Jones, KA1
Morgan, MJ3
Sherwood, AR2
Hudson, JI2
Gruber, S1
Kozin, D1
Pope, HG2
Kay, C1
Harper, DN1
Hunt, M1
Fogger, SA1
Rodgers, J1
Buchanan, T1
Heffernan, T1
Ling, J1
Scholey, A1
Cheng, L1
Wang, SH1
Chen, QC1
Liao, XM1
Hulka, LM1
Wagner, M2
Preller, KH1
Jenni, D1
Schaefer, TL1
Grace, CE1
Braun, AA1
Amos-Kroohs, RM1
Graham, DL1
Skelton, MR1
Williams, MT1
Vorhees, CV1
Fox, HC3
McLean, A1
Turner, JJ3
Rogers, R1
Sahakian, BJ2
Parrott, A1
Cole, JC2
Sumnall, HR2
Gouzoulis-Mayfrank, E4
Thimm, B1
Rezk, M1
Hensen, G1
Daumann, J4
Riedel, WJ1
Vik, PW1
Cellucci, T1
Jarchow, A1
Hedt, J1
Barry, S1
Yurgelun-Todd, D1
Lyvers, M2
Hasking, P1
Murphy, P1
Wareing, M1
Verdejo-García, AJ1
López-Torrecillas, F1
Aguilar de Arcos, F1
Pérez-García, M1
Milani, RM1
Schifano, F1
Newman, RG1
Degenhardt, L1
Copeland, J1
Dillon, P1
Thomasius, R2
Petersen, KU1
Zapletalova, P2
Wartberg, L2
Zeichner, D1
Schmoldt, A2
Roiser, JP1
Rogers, RD2
Casco, C1
Forcella, M1
Beretta, G1
Grieco, A1
Campana, G1
Dafters, RI2
Medina, KL1
Shear, PK1
Corcoran, K1
Kühn, KU1
Hoppe, C1
Westheide, J1
Maier, W1
Daum, I1
Høiseth, G1
Løvåsdal, Ø1
Titze, TK1
Bramness, JG1
Bachs, L1
Petersen, K1
Buchert, R1
Andresen, B1
Nebeling, B1
Lamers, CT1
Ramaekers, JG1
Reay, JL1
Hamilton, C1
Kennedy, DO1
Scholey, AB1
Baylen, CA1
Rosenberg, H1
Smith, RM1
Tivarus, M1
Campbell, HL1
Hillier, A1
Beversdorf, DQ1
Dalley, JW1
Lääne, K1
Theobald, DE1
Peña, Y1
Bruce, CC1
Huszar, AC1
Wojcieszek, M1
Everitt, BJ1
Robbins, TW2
Kalechstein, AD1
De La Garza, R1
Mahoney, JJ1
Fantegrossi, WE1
Newton, TF1
Fischer, RB1
Golding, JF1
Groome, DH1
Rycroft, N1
Denton, Z1
Schilt, T2
de Win, MM2
Koeter, M1
Jager, G2
Korf, DJ1
Schmand, B2
Hoshi, R1
Mullins, K1
Boundy, C1
Brignell, C1
Piccini, P1
Curran, HV1
Frenzilli, G1
Ferrucci, M1
Giorgi, FS1
Blandini, F1
Nigro, M1
Ruggieri, S1
Murri, L1
Paparelli, A1
Fornai, F1
Zakzanis, KK1
Campbell, Z1
Jovanovski, D1
Koeter, MW1
Ramsey, NF1
Yücel, M1
Lubman, DI1
Solowij, N1
Brewer, WJ1
Peters, GJ1
Kok, G1
Abraham, C1
Karlsen, SN1
Spigset, O1
Slørdal, L1
de Sola Llopis, S1
Miguelez-Pan, M1
Peña-Casanova, J1
Poudevida, S1
Farré, M1
Pacifici, R1
Böhm, P1
Abanades, S1
Verdejo García, A1
Langohr, K1
Zuccaro, P1
de la Torre, R1
Bedi, G1
Redman, J1
Sullwold, K1
Mueller, PD1
Korey, WS1
McGuire, P1
Kelly, PA2
Tuchtenhagen, F1
Pelz, S1
Becker, S1
Kunert, HJ1
Fimm, B1
Sass, H1
Croft, RJ1
Mackay, AJ1
Mills, AT1
Gruzelier, JG1
Bhattachary, S1
Powell, JH1
McFie, L1
Fleetwood, H1
Robinson, JA1
Wagstaff, GF1
Krystal, JH1
Price, LH1
Opsahl, C1
Heninger, GR1

Reviews

26 reviews available for n-methyl-3,4-methylenedioxyamphetamine and Cognition Disorders

ArticleYear
MDMA and brain activity during neurocognitive performance: An overview of neuroimaging studies with abstinent 'Ecstasy' users.
    Neuroscience and biobehavioral reviews, 2018, Volume: 84

    Topics: Brain; Cognition Disorders; Electroencephalography; Functional Neuroimaging; Humans; N-Methyl-3,4-me

2018
Modulation of 3,4-methylenedioxymethamphetamine effects by endocannabinoid system.
    Current pharmaceutical design, 2013, Volume: 19, Issue:40

    Topics: Amphetamine-Related Disorders; Animals; Cannabinoids; Cannabis; Cognition Disorders; Endocannabinoid

2013
MDMA, serotonergic neurotoxicity, and the diverse functional deficits of recreational 'Ecstasy' users.
    Neuroscience and biobehavioral reviews, 2013, Volume: 37, Issue:8

    Topics: Amphetamine-Related Disorders; Cognition; Cognition Disorders; Humans; Illicit Drugs; Memory; N-Meth

2013
[The cognitive effects of ecstasy].
    Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology, 2013, Volume: 15, Issue:4

    Topics: Cerebrovascular Circulation; Circadian Rhythm; Cognition; Cognition Disorders; Endocannabinoids; Fev

2013
Functional Magnetic Resonance Imaging in Abstinent MDMA Users: A Review.
    Current drug abuse reviews, 2015, Volume: 8, Issue:1

    Topics: Amphetamine-Related Disorders; Animals; Brain; Cognition; Cognition Disorders; Hallucinogens; Humans

2015
Decision-making in chronic ecstasy users: a systematic review.
    The European journal of neuroscience, 2017, Volume: 45, Issue:1

    Topics: Animals; Cognition Disorders; Decision Making; Humans; Memory Disorders; N-Methyl-3,4-methylenedioxy

2017
Altered states: the clinical effects of Ecstasy.
    Pharmacology & therapeutics, 2003, Volume: 98, Issue:1

    Topics: 3,4-Methylenedioxyamphetamine; Brain; Clinical Trials as Topic; Cognition Disorders; Hallucinogens;

2003
Cognitive impairment in substance abuse.
    The Psychiatric clinics of North America, 2004, Volume: 27, Issue:1

    Topics: Alcohol Amnestic Disorder; Amphetamines; Central Nervous System Stimulants; Cognition Disorders; Eth

2004
Have Halpern et al. (2004) detected 'residual neuropsychological effects' of MDMA? Not likely.
    Drug and alcohol dependence, 2004, Aug-16, Volume: 75, Issue:2

    Topics: Cognition Disorders; Humans; N-Methyl-3,4-methylenedioxyamphetamine; Neuropsychological Tests

2004
Recent trends in the use of "club drugs": an Australian review.
    Substance use & misuse, 2005, Volume: 40, Issue:9-10

    Topics: Adjuvants, Anesthesia; Adolescent; Adult; Anesthetics, Dissociative; Australia; Cognition Disorders;

2005
Neurotoxicity of methylenedioxyamphetamines (MDMA; ecstasy) in humans: how strong is the evidence for persistent brain damage?
    Addiction (Abingdon, England), 2006, Volume: 101, Issue:3

    Topics: Animals; Brain Diseases; Cognition Disorders; Hallucinogens; Humans; Memory Disorders; Mental Disord

2006
[Psychiatric and cognitive long-term effects of ecstasy].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 2006, Feb-23, Volume: 126, Issue:5

    Topics: Animals; Brain; Cognition Disorders; Cross-Sectional Studies; Hallucinogens; Humans; Longitudinal St

2006
MDMA in humans: factors which affect the neuropsychobiological profiles of recreational ecstasy users, the integrative role of bioenergetic stress.
    Journal of psychopharmacology (Oxford, England), 2006, Volume: 20, Issue:2

    Topics: Affect; Amphetamine-Related Disorders; Brain; Cannabinoids; Cognition Disorders; Drug Interactions;

2006
The confounding problem of polydrug use in recreational ecstasy/MDMA users: a brief overview.
    Journal of psychopharmacology (Oxford, England), 2006, Volume: 20, Issue:2

    Topics: Amphetamine-Related Disorders; Brain; Cannabinoids; Cell Survival; Cognition Disorders; Hallucinogen

2006
Mood, cognition and serotonin transporter availability in current and former ecstasy (MDMA) users: the longitudinal perspective.
    Journal of psychopharmacology (Oxford, England), 2006, Volume: 20, Issue:2

    Topics: Affect; Amphetamine-Related Disorders; Brain; Cognition Disorders; Cross-Sectional Studies; Dose-Res

2006
Recreational ecstasy use and the neurotoxic potential of MDMA: current status of the controversy and methodological issues.
    Drug and alcohol review, 2006, Volume: 25, Issue:3

    Topics: Amphetamine-Related Disorders; Animals; Brain; Cognition Disorders; Diagnostic Imaging; Disease Mode

2006
A review of the acute subjective effects of MDMA/ecstasy.
    Addiction (Abingdon, England), 2006, Volume: 101, Issue:7

    Topics: Adolescent; Adult; Aged; Cognition; Cognition Disorders; Emotions; Female; Hallucinogens; Humans; Il

2006
MDMA use and neurocognition: a meta-analytic review.
    Psychopharmacology, 2007, Volume: 189, Issue:4

    Topics: Amphetamine-Related Disorders; Attention; Cognition; Cognition Disorders; Hallucinogens; Humans; Lea

2007
The neuropsychology of ecstasy (MDMA) use: a quantitative review.
    Human psychopharmacology, 2007, Volume: 22, Issue:7

    Topics: Attention; Cognition Disorders; Hallucinogens; Humans; Learning; Memory; N-Methyl-3,4-methylenedioxy

2007
Understanding drug addiction: a neuropsychological perspective.
    The Australian and New Zealand journal of psychiatry, 2007, Volume: 41, Issue:12

    Topics: Adolescent; Adult; Age Factors; Alcoholism; Analgesics, Opioid; Behavior, Addictive; Central Nervous

2007
Social cognitive determinants of ecstasy use to target in evidence-based interventions: a meta-analytical review.
    Addiction (Abingdon, England), 2008, Volume: 103, Issue:1

    Topics: Adaptation, Psychological; Amphetamine-Related Disorders; Cognition Disorders; Evidence-Based Medici

2008
The dark side of ecstasy: neuropsychiatric symptoms after exposure to 3,4-methylenedioxymethamphetamine.
    Basic & clinical pharmacology & toxicology, 2008, Volume: 102, Issue:1

    Topics: Animals; Cognition Disorders; Dose-Response Relationship, Drug; Half-Life; Hallucinogens; Humans; Il

2008
Long term psychiatric and cognitive effects of MDMA use.
    Toxicology letters, 2000, Mar-15, Volume: 112-113

    Topics: Chronic Disease; Cognition Disorders; Hallucinogens; Humans; Memory Disorders; Mental Recall; N-Meth

2000
Ecstasy (MDMA): a review of its possible persistent psychological effects.
    Psychopharmacology, 2000, Volume: 152, Issue:3

    Topics: Affect; Aggression; Animals; Anxiety; Brain; Cognition Disorders; Humans; Memory; N-Methyl-3,4-methy

2000
Investigating the neurocognitive deficits associated with chronic drug misuse.
    Current opinion in neurobiology, 2001, Volume: 11, Issue:2

    Topics: Animals; Chronic Disease; Cocaine-Related Disorders; Cognition Disorders; Humans; Marijuana Abuse; N

2001
Recreational Ecstasy/MDMA, the serotonin syndrome, and serotonergic neurotoxicity.
    Pharmacology, biochemistry, and behavior, 2002, Volume: 71, Issue:4

    Topics: Animals; Cognition Disorders; Humans; Memory Disorders; N-Methyl-3,4-methylenedioxyamphetamine; Neur

2002

Trials

4 trials available for n-methyl-3,4-methylenedioxyamphetamine and Cognition Disorders

ArticleYear
Electrophysiological evidence of atypical processing underlying mental set shifting in ecstasy polydrug and polydrug users.
    Experimental and clinical psychopharmacology, 2013, Volume: 21, Issue:6

    Topics: Adult; Analysis of Variance; Attention; Central Nervous System Stimulants; Cognition Disorders; Elec

2013
Pattern of cannabis use in ecstasy polydrug users: moderate cannabis use may compensate for self-rated aggression and somatic symptoms.
    Human psychopharmacology, 2005, Volume: 20, Issue:4

    Topics: Adult; Aggression; Alcohol Drinking; Cognition Disorders; Drug Interactions; Family; Female; Humans;

2005
Cognitive function and mood in MDMA/THC users, THC users and non-drug using controls.
    Journal of psychopharmacology (Oxford, England), 2006, Volume: 20, Issue:2

    Topics: Adult; Amphetamine-Related Disorders; Anxiety; Cognition Disorders; Decision Making; Depression; Dis

2006
Ecstasy use: cognitive deficits related to dosage rather than self-reported problematic use of the drug.
    Journal of psychopharmacology (Oxford, England), 2001, Volume: 15, Issue:4

    Topics: Adult; Cognition Disorders; Female; Hallucinogens; Humans; Male; Memory, Short-Term; Mental Disorder

2001

Other Studies

65 other studies available for n-methyl-3,4-methylenedioxyamphetamine and Cognition Disorders

ArticleYear
Cognitive functioning associated with stimulant use in patients with non-affective psychosis, their unaffected siblings and healthy controls.
    Psychological medicine, 2014, Volume: 44, Issue:9

    Topics: Adrenergic Uptake Inhibitors; Adult; Amphetamines; Central Nervous System Stimulants; Cocaine; Cogni

2014
Cognitive disorders after sporadic ecstasy use? A case report.
    Neurocase, 2015, Volume: 21, Issue:3

    Topics: Adult; Atrophy; Cognition Disorders; Hippocampus; Humans; Magnetic Resonance Imaging; Male; Memory;

2015
MDMA administration during adolescence exacerbates MPTP-induced cognitive impairment and neuroinflammation in the hippocampus and prefrontal cortex.
    Psychopharmacology, 2014, Volume: 231, Issue:20

    Topics: Animals; Astrocytes; CD11b Antigen; Cognition; Cognition Disorders; Glial Fibrillary Acidic Protein;

2014
Differences in prefrontal blood oxygenation during an acute multitasking stressor in ecstasy polydrug users.
    Psychological medicine, 2015, Volume: 45, Issue:2

    Topics: Adolescent; Adult; Case-Control Studies; Cognition Disorders; Drug Users; Female; Hallucinogens; Hum

2015
Reduced memory skills and increased hair cortisol levels in recent Ecstasy/MDMA users: significant but independent neurocognitive and neurohormonal deficits.
    Human psychopharmacology, 2015, Volume: 30, Issue:3

    Topics: Adolescent; Adult; Amphetamine-Related Disorders; Cognition Disorders; Female; Hair; Hallucinogens;

2015
Cortical oxygenation suggests increased effort during cognitive inhibition in ecstasy polydrug users.
    Journal of psychopharmacology (Oxford, England), 2015, Volume: 29, Issue:11

    Topics: Adult; Case-Control Studies; Cognition Disorders; Drug Users; Female; Functional Neuroimaging; Human

2015
Cognitive and behavioural effects induced by social stress plus MDMA administration in mice.
    Behavioural brain research, 2017, 02-15, Volume: 319

    Topics: Analysis of Variance; Animals; Avoidance Learning; Behavioral Symptoms; Body Temperature; Cognition

2017
Hippocampal remodelling after MDMA neurotoxicity: a single case study.
    The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry, 2009, Volume: 10, Issue:4 Pt 3

    Topics: Adolescent; Anticonvulsants; Body Temperature Regulation; Cognition Disorders; Electroencephalograph

2009
Importance of psychiatric confounding in non-randomized studies of heavy ecstasy users.
    Psychological medicine, 2009, Volume: 39, Issue:5

    Topics: Alcohol Drinking; Alcoholism; Amphetamine-Related Disorders; Bias; Cognition Disorders; Comorbidity;

2009
High suicide risk after the development of cognitive and working memory deficits caused by cannabis, cocaine and ecstasy use.
    Substance abuse, 2007, Volume: 28, Issue:1

    Topics: Adult; Cocaine-Related Disorders; Cognition Disorders; Humans; Male; Marijuana Abuse; Memory Disorde

2007
Sleep deprivation differentially impairs cognitive performance in abstinent methylenedioxymethamphetamine ("Ecstasy") users.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009, Nov-04, Volume: 29, Issue:44

    Topics: Adult; Cognition; Cognition Disorders; Female; Humans; Male; N-Methyl-3,4-methylenedioxyamphetamine;

2009
Is moderate substance use associated with altered executive functioning in a population-based sample of young adults?
    Human psychopharmacology, 2009, Volume: 24, Issue:8

    Topics: Adult; Alcohol Drinking; Cognition Disorders; Databases, Factual; Executive Function; Female; Humans

2009
Brain serotonin, psychoactive drugs, and effects on reproduction.
    Central nervous system agents in medicinal chemistry, 2009, Volume: 9, Issue:4

    Topics: Affect; Amphetamine-Related Disorders; Animals; Biological Clocks; Brain; Cognition Disorders; Depre

2009
Effects of the endogenous PPAR-alpha agonist, oleoylethanolamide on MDMA-induced cognitive deficits in mice.
    Synapse (New York, N.Y.), 2010, Volume: 64, Issue:5

    Topics: Animals; Avoidance Learning; Cognition Disorders; Corpus Striatum; Dopamine Plasma Membrane Transpor

2010
Everyday and prospective memory deficits in ecstasy/polydrug users.
    Journal of psychopharmacology (Oxford, England), 2011, Volume: 25, Issue:4

    Topics: Cognition; Cognition Disorders; Comprehension; Female; Humans; Illicit Drugs; Male; Memory; Memory D

2011
Risky car following in abstinent users of MDMA.
    Accident; analysis and prevention, 2010, Volume: 42, Issue:3

    Topics: Adrenergic Uptake Inhibitors; Adult; Attention; Automobile Driving; Automobiles; Cognition; Cognitio

2010
Neurocognitive impairments in MDMA and other drug users: MDMA alone may not be a cognitive risk factor.
    Journal of clinical and experimental neuropsychology, 2010, Volume: 32, Issue:4

    Topics: Adolescent; Adult; Cognition Disorders; Female; Hallucinogens; Humans; Inhibition, Psychological; Lo

2010
Procedural and declarative memory task performance, and the memory consolidation function of sleep, in recent and abstinent ecstasy/MDMA users.
    Journal of psychopharmacology (Oxford, England), 2011, Volume: 25, Issue:4

    Topics: Adult; Amphetamine-Related Disorders; Cognition; Cognition Disorders; Female; Humans; Illicit Drugs;

2011
Residual neurocognitive features of long-term ecstasy users with minimal exposure to other drugs.
    Addiction (Abingdon, England), 2011, Volume: 106, Issue:4

    Topics: Adolescent; Adult; Case-Control Studies; Chronic Disease; Cognition; Cognition Disorders; Confoundin

2011
The effects of binge MDMA on acquisition and reversal learning in a radial-arm maze task.
    Neurobiology of learning and memory, 2011, Volume: 95, Issue:4

    Topics: Adaptation, Psychological; Analysis of Variance; Animals; Behavior, Animal; Cognition Disorders; Dis

2011
Update on ecstasy.
    Journal of psychosocial nursing and mental health services, 2011, Volume: 49, Issue:4

    Topics: Adolescent; Adrenergic Uptake Inhibitors; Amphetamine-Related Disorders; Anxiety Disorders; Cognitio

2011
'Ecstasy use, by itself, does not result in residual neurotoxicity'- a powerful argument?
    Addiction (Abingdon, England), 2011, Volume: 106, Issue:7

    Topics: Cognition Disorders; Epidemiologic Factors; Humans; N-Methyl-3,4-methylenedioxyamphetamine; Substanc

2011
Moderate noise induced cognition impairment of mice and its underlying mechanisms.
    Physiology & behavior, 2011, Oct-24, Volume: 104, Issue:5

    Topics: Acoustic Stimulation; Animals; Auditory Cortex; Avoidance Learning; Behavior, Animal; Cognition Diso

2011
Blue-yellow colour vision impairment and cognitive deficits in occasional and dependent stimulant users.
    The international journal of neuropsychopharmacology, 2013, Volume: 16, Issue:3

    Topics: Adolescent; Adult; Amphetamine-Related Disorders; Central Nervous System Stimulants; Cocaine-Related

2013
Self-reports of executive dysfunction in current ecstasy/polydrug Users.
    Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology, 2012, Volume: 25, Issue:3

    Topics: Adolescent; Adult; Cognition Disorders; Diagnostic Self Evaluation; Drug Users; Executive Function;

2012
Cognitive impairments from developmental exposure to serotonergic drugs: citalopram and MDMA.
    The international journal of neuropsychopharmacology, 2013, Volume: 16, Issue:6

    Topics: Animals; Animals, Newborn; Body Weight; Citalopram; Cognition Disorders; Disease Models, Animal; Fem

2013
Neuropsychological evidence of a relatively selective profile of temporal dysfunction in drug-free MDMA ("ecstasy") polydrug users.
    Psychopharmacology, 2002, Volume: 162, Issue:2

    Topics: Adolescent; Adult; Association Learning; Attention; Cognition Disorders; Decision Making; Female; Ha

2002
Cognitive deficits and cognitive normality in recreational cannabis and Ecstasy/MDMA users.
    Human psychopharmacology, 2003, Volume: 18, Issue:2

    Topics: Cannabis; Cognition; Cognition Disorders; Hallucinogens; Humans; Illicit Drugs; N-Methyl-3,4-methyle

2003
Selective neurocognitive deficits associated with multiple doses of ecstasy/MDMA: a reply to Cole.
    Journal of psychopharmacology (Oxford, England), 2003, Volume: 17, Issue:2

    Topics: Clinical Trials as Topic; Cognition Disorders; Dose-Response Relationship, Drug; Hallucinogens; Huma

2003
Memory impairment suggests hippocampal dysfunction in abstinent ecstasy users.
    Progress in neuro-psychopharmacology & biological psychiatry, 2003, Volume: 27, Issue:5

    Topics: Adult; Analysis of Variance; Cognition Disorders; Female; Hippocampus; Humans; Male; Memory Disorder

2003
Cognitive changes after acute tryptophan depletion: what can they tell us?
    Psychological medicine, 2004, Volume: 34, Issue:1

    Topics: Alzheimer Disease; Cognition Disorders; Depressive Disorder, Major; Human Experimentation; Humans; N

2004
Neurocognitive function in users of MDMA: the importance of clinically significant patterns of use.
    Psychological medicine, 2004, Volume: 34, Issue:2

    Topics: Adolescent; Adult; Brain; Cognition Disorders; Depression; Diagnostic and Statistical Manual of Ment

2004
Residual neuropsychological effects of illicit 3,4-methylenedioxymethamphetamine (MDMA) in individuals with minimal exposure to other drugs.
    Drug and alcohol dependence, 2004, Aug-16, Volume: 75, Issue:2

    Topics: Adolescent; Adult; Cognition Disorders; Female; Humans; Male; Middle Aged; N-Methyl-3,4-methylenedio

2004
Evidence for executive deficits among users of MDMA (Ecstasy).
    British journal of psychology (London, England : 1953), 2004, Volume: 95, Issue:Pt 4

    Topics: Adult; Cognition; Cognition Disorders; Female; Hallucinogens; Humans; Male; N-Methyl-3,4-methylenedi

2004
Differential effects of MDMA, cocaine, and cannabis use severity on distinctive components of the executive functions in polysubstance users: a multiple regression analysis.
    Addictive behaviors, 2005, Volume: 30, Issue:1

    Topics: Adult; Alcoholism; Cocaine-Related Disorders; Cognition Disorders; Female; Humans; Male; Marijuana A

2005
Comment on Soar, et al.'s case study of problems and use of Ecstasy.
    Psychological reports, 2005, Volume: 96, Issue:2

    Topics: Cognition Disorders; Humans; N-Methyl-3,4-methylenedioxyamphetamine; Substance-Related Disorders; Ti

2005
Mental disorders in current and former heavy ecstasy (MDMA) users.
    Addiction (Abingdon, England), 2005, Volume: 100, Issue:9

    Topics: Adult; Amphetamine-Related Disorders; Anxiety Disorders; Cognition Disorders; Cross-Sectional Studie

2005
Neuropsychological function in ecstasy users: a study controlling for polydrug use.
    Psychopharmacology, 2007, Volume: 189, Issue:4

    Topics: Amphetamine-Related Disorders; Cognition; Cognition Disorders; Cross-Sectional Studies; Decision Mak

2007
Long-term effects of MDMA (Ecstasy) on the human central nervous system revealed by visual evoked potentials.
    Addiction biology, 2005, Volume: 10, Issue:2

    Topics: Adult; Amphetamine-Related Disorders; Central Nervous System; Cognition Disorders; Electroencephalog

2005
Impulsivity, inhibition and negative priming in ecstasy users.
    Addictive behaviors, 2006, Volume: 31, Issue:8

    Topics: Adult; Cannabis; Cognition Disorders; Female; Humans; Impulsive Behavior; Inhibition, Psychological;

2006
Ecstasy (MDMA) exposure and neuropsychological functioning: a polydrug perspective.
    Journal of the International Neuropsychological Society : JINS, 2005, Volume: 11, Issue:6

    Topics: Adolescent; Adult; Analysis of Variance; Chi-Square Distribution; Cognition; Cognition Disorders; De

2005
Chronic ecstasy (MDMA) use is associated with deficits in task-switching but not inhibition or memory updating executive functions.
    Drug and alcohol dependence, 2006, Jun-28, Volume: 83, Issue:2

    Topics: Adult; Chronic Disease; Cognition Disorders; Female; Humans; Inhibition, Psychological; Male; Memory

2006
Elevated impulsivity and impaired decision-making cognition in heavy users of MDMA ("Ecstasy").
    Psychopharmacology, 2007, Volume: 189, Issue:4

    Topics: Adult; Amphetamine-Related Disorders; Case-Control Studies; Cognition; Cognition Disorders; Decision

2007
MDMA polydrug users show process-specific central executive impairments coupled with impaired social and emotional judgement processes.
    Journal of psychopharmacology (Oxford, England), 2006, Volume: 20, Issue:3

    Topics: Adolescent; Adult; Alcoholism; Amphetamine-Related Disorders; Attention; Cocaine-Related Disorders;

2006
Apparent transient effects of recent "ecstasy" use on cognitive performance and extrapyramidal signs in human subjects.
    Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology, 2006, Volume: 19, Issue:3

    Topics: Adult; Analysis of Variance; Basal Ganglia Diseases; Blinking; Cognition; Cognition Disorders; Extra

2006
Enduring deficits in sustained visual attention during withdrawal of intravenous methylenedioxymethamphetamine self-administration in rats: results from a comparative study with d-amphetamine and methamphetamine.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2007, Volume: 32, Issue:5

    Topics: Amphetamine-Related Disorders; Amphetamines; Animals; Attention; Attention Deficit Disorder with Hyp

2007
[Psychiatric illness associated with amphetamines and other stimulants].
    Psychiatrische Praxis, 2000, Volume: 27, Issue:4

    Topics: Adult; Amnesia; Amphetamines; Central Nervous System Stimulants; Cognition Disorders; Designer Drugs

2000
Cognitive performance in light current users and ex-users of ecstasy (MDMA) and controls.
    The American journal of drug and alcohol abuse, 2007, Volume: 33, Issue:2

    Topics: Adult; Analysis of Variance; Case-Control Studies; Cognition Disorders; Female; Humans; Male; Memory

2007
Cognition in novice ecstasy users with minimal exposure to other drugs: a prospective cohort study.
    Archives of general psychiatry, 2007, Volume: 64, Issue:6

    Topics: Adult; Attention; Cannabis; Cognition; Cognition Disorders; Cohort Studies; Female; Follow-Up Studie

2007
Neurocognitive function in current and ex-users of ecstasy in comparison to both matched polydrug-using controls and drug-naïve controls.
    Psychopharmacology, 2007, Volume: 194, Issue:3

    Topics: Adult; Case-Control Studies; Cognition Disorders; Hallucinogens; Humans; Illicit Drugs; Learning; Ma

2007
Everyday memory deficits in ecstasy-polydrug users.
    Journal of psychopharmacology (Oxford, England), 2007, Volume: 21, Issue:7

    Topics: Adult; Cannabis; Cognition Disorders; Female; Hallucinogens; Humans; Illicit Drugs; Linear Models; M

2007
DNA fragmentation and oxidative stress in the hippocampal formation: a bridge between 3,4-methylenedioxymethamphetamine (ecstasy) intake and long-lasting behavioral alterations.
    Behavioural pharmacology, 2007, Volume: 18, Issue:5-6

    Topics: Animals; Behavior, Animal; Cognition Disorders; Comet Assay; Disease Models, Animal; DNA Breaks, Dou

2007
Specific effects of ecstasy and other illicit drugs on cognition in poly-substance users.
    Psychological medicine, 2008, Volume: 38, Issue:9

    Topics: Adolescent; Adult; Amphetamine; Attention; Cannabis; Central Nervous System Stimulants; Cocaine; Cog

2008
Cognitive performance in recreational ecstasy polydrug users: a two-year follow-up study.
    Journal of psychopharmacology (Oxford, England), 2008, Volume: 22, Issue:5

    Topics: Adult; Cognition Disorders; Drug Synergism; Female; Follow-Up Studies; Hallucinogens; Humans; Illici

2008
Ecstasy use and higher-level cognitive functions: weak effects of ecstasy after control for potential confounds.
    Psychological medicine, 2008, Volume: 38, Issue:9

    Topics: Adult; Affect; Attention; Cannabis; Cognition; Cognition Disorders; Cohort Studies; Cross-Sectional

2008
Reward-related decision-making deficits and elevated impulsivity among MDMA and other drug users.
    Drug and alcohol dependence, 2008, Jul-01, Volume: 96, Issue:1-2

    Topics: Adult; Alcohol Drinking; Amphetamine-Related Disorders; Cognition Disorders; Control Groups; Decisio

2008
Death by "ecstasy": the serotonin syndrome?
    Annals of emergency medicine, 1998, Volume: 32, Issue:3 Pt 1

    Topics: Adult; Arrhythmias, Cardiac; Autonomic Nervous System Diseases; Cognition Disorders; Epilepsy, Tonic

1998
Impaired cognitive performance in drug free users of recreational ecstasy (MDMA)
    Journal of neurology, neurosurgery, and psychiatry, 2000, Volume: 68, Issue:6

    Topics: Cognition Disorders; Humans; N-Methyl-3,4-methylenedioxyamphetamine; Neuropsychological Tests; Subst

2000
Impaired cognitive performance in drug free users of recreational ecstasy (MDMA)
    Journal of neurology, neurosurgery, and psychiatry, 2000, Volume: 68, Issue:6

    Topics: Adolescent; Adult; Attention; Cognition Disorders; Female; Hallucinogens; Humans; Intelligence; Lear

2000
Does recreational ecstasy use cause long-term cognitive problems?
    The Western journal of medicine, 2000, Volume: 173, Issue:2

    Topics: Animals; Cognition Disorders; Humans; Illicit Drugs; N-Methyl-3,4-methylenedioxyamphetamine; Neuroto

2000
The relative contributions of ecstasy and cannabis to cognitive impairment.
    Psychopharmacology, 2001, Volume: 153, Issue:3

    Topics: Adolescent; Adult; Analysis of Variance; Cognition; Cognition Disorders; Dronabinol; Female; Halluci

2001
Recreational use of 3,4-methylenedioxymethamphetamine (MDMA) or 'ecstasy': evidence for cognitive impairment.
    Psychological medicine, 2001, Volume: 31, Issue:4

    Topics: Adult; Cognition Disorders; Female; Hallucinogens; Humans; Intelligence Tests; Male; Mental Recall;

2001
Ecstasy (MDMA): are the psychological problems associated with its use reversed by prolonged abstinence?
    Psychopharmacology, 2002, Volume: 159, Issue:3

    Topics: Adult; Analysis of Variance; Cognition Disorders; Female; Hallucinogens; Humans; Impulsive Behavior;

2002
What is a dose of ecstasy?
    Journal of psychopharmacology (Oxford, England), 2002, Volume: 16, Issue:2

    Topics: Cognition Disorders; Dose-Response Relationship, Drug; Hallucinogens; Humans; N-Methyl-3,4-methylene

2002
Chronic 3,4-methylenedioxymethamphetamine (MDMA) use: effects on mood and neuropsychological function?
    The American journal of drug and alcohol abuse, 1992, Volume: 18, Issue:3

    Topics: 3,4-Methylenedioxyamphetamine; Adult; Cognition Disorders; Depressive Disorder; Female; Humans; Male

1992