n-methyl-3,4-methylenedioxyamphetamine has been researched along with Chemical and Drug Induced Liver Injury in 37 studies
N-Methyl-3,4-methylenedioxyamphetamine: An N-substituted amphetamine analog. It is a widely abused drug classified as a hallucinogen and causes marked, long-lasting changes in brain serotonergic systems. It is commonly referred to as MDMA or ecstasy.
3,4-methylenedioxymethamphetamine : A member of the class of benzodioxoles that is 1,3-benzodioxole substituted by a 2-(methylamino)propyl group at position 5.
Chemical and Drug Induced Liver Injury: A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Jaundice, hepatomegaly, centrilobular necrosis, hepatitis and fibrosis represent some of the adverse effects caused by MDMA in the liver." | 2.46 | Mechanisms underlying the hepatotoxic effects of ecstasy. ( Bastos, ML; Carvalho, F; Carvalho, M; Pontes, H; Remião, F, 2010) |
| "3,4-Methylenedioxymethamphetamine (MDMA, ecstasy) has become a popular recreational drug of abuse among young adults, partly because of the belief that it is relatively safe compared with other drugs with the same stimulant and hallucinogenic effects." | 1.51 | MDMA-Associated Liver Toxicity: Pathophysiology, Management, and Current State of Knowledge. ( Cajanding, RJM, 2019) |
| " These outcomes suggest that MDMA metabolism has hazard implications to liver cells even when metabolites are found in low concentrations, as they contribute additively to the overall toxic effect of MDMA." | 1.40 | Mixtures of 3,4-methylenedioxymethamphetamine (ecstasy) and its major human metabolites act additively to induce significant toxicity to liver cells when combined at low, non-cytotoxic concentrations. ( Carmo, H; Carvalho, F; da Silva, DD; Silva, E, 2014) |
| " We finally concluded that hyperthermia could potentiate MDMA induced liver toxicity probably through a mitochondrial/lysosomal toxic cross-talk in freshly isolated rat hepatocytes." | 1.36 | Involvement of mitochondrial/lysosomal toxic cross-talk in ecstasy induced liver toxicity under hyperthermic condition. ( Eskandari, MR; Khajeamiri, AR; Kobarfard, F; Nosrati, M; Pourahmad, J, 2010) |
| "Within 10 days the patient developed acute liver failure." | 1.31 | [Acute liver failure following the use of ecstasy (MDMA)]. ( Berg, T; Fliege, H; Klapp, BF; Lange-Brock, N; Mönnikes, H; Müller, AR; Neuhaus, P; Wiedenmann, B, 2002) |
| " The toxic effect of MDMA was also observed in other hepatic processes." | 1.31 | Ecstasy-induced toxicity in rat liver. ( Beitia, G; Cenarruzabeitia, E; Cobreros, A; Sainz, L, 2000) |
| "An idiosyncratic toxic hepatitis might be due to either 3,4-methylenedioxymethylamphetamine or a metabolite, a contaminant in 3,4-methylenedioxymethylamphetamine manufacture, or to an additive in tablet or capsule formulation." | 1.29 | [Acute hepatitis due to ingestion of Ecstasy]. ( Huarte Muniesa, MP; Pueyo Royo, AM, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 15 (40.54) | 18.2507 |
| 2000's | 16 (43.24) | 29.6817 |
| 2010's | 5 (13.51) | 24.3611 |
| 2020's | 1 (2.70) | 2.80 |
| Authors | Studies |
|---|---|
| Cajanding, RJM | 1 |
| Araújo, AM | 1 |
| Enea, M | 1 |
| Fernandes, E | 2 |
| Carvalho, F | 4 |
| de Lourdes Bastos, M | 1 |
| Carvalho, M | 2 |
| Guedes de Pinho, P | 1 |
| da Silva, DD | 1 |
| Silva, E | 1 |
| Carmo, H | 2 |
| Pontes, H | 2 |
| Duarte, JA | 1 |
| de Pinho, PG | 1 |
| Soares, ME | 1 |
| Dinis-Oliveira, RJ | 1 |
| Sousa, C | 1 |
| Silva, R | 1 |
| Casal, S | 1 |
| Remião, F | 2 |
| Bastos, ML | 2 |
| Upreti, VV | 1 |
| Eddington, ND | 1 |
| Moon, KH | 1 |
| Song, BJ | 1 |
| Lee, IJ | 1 |
| Pourahmad, J | 1 |
| Eskandari, MR | 1 |
| Nosrati, M | 1 |
| Kobarfard, F | 1 |
| Khajeamiri, AR | 1 |
| Colak, Y | 1 |
| Tuncer, I | 1 |
| Enc, FY | 1 |
| Ozturk, O | 1 |
| Kiziltas, S | 1 |
| Ulasoglu, C | 1 |
| Lange-Brock, N | 1 |
| Berg, T | 1 |
| Müller, AR | 1 |
| Fliege, H | 1 |
| Neuhaus, P | 1 |
| Wiedenmann, B | 1 |
| Klapp, BF | 1 |
| Mönnikes, H | 1 |
| Núñez, O | 1 |
| Bañares, R | 1 |
| Barrio, J | 1 |
| Menchén, L | 1 |
| Diego, Ad | 1 |
| Salinero, E | 1 |
| Clemente, G | 1 |
| Nosari, A | 1 |
| Marbello, L | 1 |
| De Carlis, LG | 1 |
| De Gasperi, A | 1 |
| Muti, G | 1 |
| Mancini, V | 1 |
| Morra, E | 1 |
| Aknine, X | 1 |
| Salzmann, J | 1 |
| Marie-Claire, C | 1 |
| Noble, F | 1 |
| Muñoz, P | 1 |
| Drobinska, A | 1 |
| Bianchi, L | 1 |
| Züger, Ch | 1 |
| Pirovino, M | 1 |
| Caudevilla Gálligo, F | 1 |
| Bouso Saiz, JC | 1 |
| Brncić, N | 1 |
| Kraus, I | 1 |
| Visković, I | 1 |
| Mijandrusić-Sincić, B | 1 |
| Vlahović-Palcevski, V | 1 |
| Kis, L | 1 |
| Pfaffenberger, M | 1 |
| Huarte Muniesa, MP | 1 |
| Pueyo Royo, AM | 1 |
| Dykhuizen, RS | 1 |
| Brunt, PW | 1 |
| Atkinson, P | 1 |
| Simpson, JG | 1 |
| Smith, CC | 1 |
| Skopp, G | 1 |
| Aderjan, R | 1 |
| Koster, J | 1 |
| Khakoo, SI | 1 |
| Coles, CJ | 1 |
| Armstrong, JS | 1 |
| Barry, RE | 1 |
| Oranje, WA | 1 |
| von Pol, P | 1 |
| vd Wurff, A | 1 |
| Zeijen, RN | 1 |
| Stockbrügger, RW | 1 |
| Arends, JW | 1 |
| de Man, RA | 2 |
| Wilson, JH | 1 |
| Tjen, HS | 1 |
| Pascual Bartolomé, S | 1 |
| Sarrión Martínez, JV | 1 |
| García Herola, A | 1 |
| Berenguer Lapuerta, J | 1 |
| Giner Durán, R | 1 |
| Flors, H | 1 |
| Millán, M | 1 |
| Manzanera, R | 1 |
| Roques, V | 1 |
| Perney, P | 1 |
| Beaufort, P | 1 |
| Hanslik, B | 1 |
| Ramos, J | 1 |
| Durand, L | 1 |
| Le Bricquir, Y | 1 |
| Blanc, F | 1 |
| Friebe, M | 1 |
| Kindler, U | 1 |
| Indart Pérez, A | 1 |
| Mendia Gorostidi, A | 1 |
| Barrio Andrés, J | 1 |
| Arens Miravé, I | 1 |
| Beitia, G | 1 |
| Cobreros, A | 1 |
| Sainz, L | 1 |
| Cenarruzabeitia, E | 1 |
| Shiloach, E | 1 |
| Zecler, E | 1 |
| Horowiz, M | 1 |
| Scapa, E | 1 |
| Shibolet, O | 1 |
| Kalish, Y | 1 |
| Gillis, S | 1 |
| Ilan, Y | 1 |
| Hwang, I | 1 |
| Daniels, AM | 1 |
| Holtzmuller, KC | 1 |
| Chaudier, B | 1 |
| Oliver, M | 1 |
| Coton, T | 1 |
| Civatte, M | 1 |
| Guisset, M | 1 |
| Carré, D | 1 |
| Debonne, JM | 1 |
| Delpy, R | 1 |
| Gorard, DA | 1 |
| Davies, SE | 1 |
| Clark, ML | 1 |
| Shearman, JD | 1 |
| Chapman, RW | 1 |
| Satsangi, J | 1 |
| Ryley, NG | 1 |
| Weatherhead, S | 1 |
5 reviews available for n-methyl-3,4-methylenedioxyamphetamine and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
Mechanisms underlying the hepatotoxic effects of ecstasy.
Topics: Animals; Chemical and Drug Induced Liver Injury; Hallucinogens; Humans; Liver; Models, Biological; N | 2010 |
[Acute and long-term effects of ecstasy].
Topics: Animals; Brain Diseases; Chemical and Drug Induced Liver Injury; Fever; Hallucinogens; Humans; N-Met | 2004 |
XTC-induced hepatitis.
Topics: 3,4-Methylenedioxyamphetamine; Acute Disease; Adult; Biopsy; Chemical and Drug Induced Liver Injury; | 1994 |
[Morbidity and mortality caused by use of ecstasy].
Topics: Chemical and Drug Induced Liver Injury; Humans; Multiple Organ Failure; N-Methyl-3,4-methylenedioxya | 1994 |
[Acute liver damage after using ecstasy].
Topics: Adult; Chemical and Drug Induced Liver Injury; Female; Hallucinogens; Humans; Liver; N-Methyl-3,4-me | 1998 |
32 other studies available for n-methyl-3,4-methylenedioxyamphetamine and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
MDMA-Associated Liver Toxicity: Pathophysiology, Management, and Current State of Knowledge.
Topics: Adolescent; Adult; Chemical and Drug Induced Liver Injury; Critical Care Nursing; Education, Nursing | 2019 |
3,4-Methylenedioxymethamphetamine Hepatotoxicity under the Heat Stress Condition: Novel Insights from in Vitro Metabolomic Studies.
Topics: Animals; Chemical and Drug Induced Liver Injury; Heat-Shock Response; Hepatocytes; Metabolomics; Mic | 2020 |
Mixtures of 3,4-methylenedioxymethamphetamine (ecstasy) and its major human metabolites act additively to induce significant toxicity to liver cells when combined at low, non-cytotoxic concentrations.
Topics: 3,4-Methylenedioxyamphetamine; Biotransformation; Cell Survival; Chemical and Drug Induced Liver Inj | 2014 |
Chronic exposure to ethanol exacerbates MDMA-induced hyperthermia and exposes liver to severe MDMA-induced toxicity in CD1 mice.
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Body Temperature; Central | 2008 |
Drug interaction between ethanol and 3,4-methylenedioxymethamphetamine ("ecstasy").
Topics: Acetaldehyde; Aldehyde Dehydrogenase; Aldehyde Dehydrogenase 1 Family; Aldehyde Dehydrogenase, Mitoc | 2009 |
Involvement of mitochondrial/lysosomal toxic cross-talk in ecstasy induced liver toxicity under hyperthermic condition.
Topics: Animals; Cell Survival; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2D6 Inhibitors; | 2010 |
Ecstasy induced fatal hepatic failure.
Topics: Chemical and Drug Induced Liver Injury; Fatal Outcome; Hallucinogens; Humans; Liver Failure, Acute; | 2011 |
[Acute liver failure following the use of ecstasy (MDMA)].
Topics: Adolescent; Biopsy; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Female; Humans; | 2002 |
[Variability of the clinical expression of Ecstasy-induced hepatotoxicity].
Topics: Abdominal Pain; Adolescent; Adult; Biopsy; Chemical and Drug Induced Liver Injury; Cholestasis, Intr | 2002 |
Bone marrow hypoplasia complicating tacrolimus (FK506) therapy.
Topics: Adolescent; Bone Marrow Diseases; Chemical and Drug Induced Liver Injury; Cyclosporine; Female; Huma | 2004 |
[Ecstasy-induced toxic hepatitis].
Topics: Adult; Alanine Transaminase; Chemical and Drug Induced Liver Injury; Hallucinogens; Humans; Liver; M | 2004 |
[Acute giant cell hepatitis in a 17-year old man].
Topics: Adolescent; Chemical and Drug Induced Liver Injury; Giant Cells; Hallucinogens; Humans; Jaundice; Li | 2004 |
[Ecstasy: is it innocuous?].
Topics: Cardiovascular Diseases; Chemical and Drug Induced Liver Injury; Clinical Trials as Topic; Cognition | 2005 |
3,4-methylenedioxymethamphetamine (MDMA): an important cause of acute hepatitis.
Topics: Adult; Alanine Transaminase; Aspartate Aminotransferases; Bilirubin; Chemical and Drug Induced Liver | 2006 |
[Painless jaundice after ecstasy and alcohol consumption].
Topics: Adult; Alcohol Drinking; Biopsy; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; | 2007 |
[Acute hepatitis due to ingestion of Ecstasy].
Topics: Acute Disease; Adult; Chemical and Drug Induced Liver Injury; Follow-Up Studies; Hallucinogens; Huma | 1995 |
Ecstasy induced hepatitis mimicking viral hepatitis.
Topics: Adult; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Hepatitis, Viral, Human; Hum | 1995 |
[Hair analysis in the diagnosis of toxic hepatitis after Ecstasy abuse].
Topics: Adolescent; Chemical and Drug Induced Liver Injury; Clinical Enzyme Tests; Hair; Humans; Male; N-Met | 1995 |
Hepatotoxicity and accelerated fibrosis following 3,4-methylenedioxymetamphetamine ("ecstasy") usage.
Topics: Adult; Chemical and Drug Induced Liver Injury; Female; Humans; Liver; Liver Cirrhosis; N-Methyl-3,4- | 1995 |
[Acute liver failure caused by methylenedioxymethamphetamine ('ecstasy')].
Topics: 3,4-Methylenedioxyamphetamine; Adolescent; Chemical and Drug Induced Liver Injury; Combined Modality | 1993 |
[Hepatitis and Ecstasy].
Topics: Administration, Oral; Adolescent; Chemical and Drug Induced Liver Injury; Hallucinogens; Humans; Mal | 1997 |
[Hepatitis from ecstasy].
Topics: Adolescent; Chemical and Drug Induced Liver Injury; Female; Hallucinogens; Humans; N-Methyl-3,4-meth | 1998 |
[Acute hepatitis due to ecstasy].
Topics: Acute Disease; Adult; Chemical and Drug Induced Liver Injury; Hallucinogens; Humans; Jaundice; Liver | 1998 |
[Acute liver failure].
Topics: Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Hallucinogens; Humans; Liver Failur | 1998 |
[Acute hepatitis induced by Ecstasy].
Topics: Acute Disease; Adult; Chemical and Drug Induced Liver Injury; Hallucinogens; Humans; Male; N-Methyl- | 1998 |
Ecstasy-induced toxicity in rat liver.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Blood Glucose; Che | 2000 |
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 6-2001. A 17-year-old girl with marked jaundice and weight loss.
Topics: Adolescent; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Female; Hallucinogens; | 2001 |
[Hepatic and hematological complications following ecstasy usage].
Topics: Adult; Chemical and Drug Induced Liver Injury; Hematologic Diseases; Humans; Liver Failure; Male; N- | 2001 |
"Ecstasy"-induced hepatitis in an active duty soldier.
Topics: Adult; Chemical and Drug Induced Liver Injury; Clinical Enzyme Tests; Hallucinogens; Humans; Male; M | 2002 |
[Chronic hepatitis with an acute presentation due to Ecstasy].
Topics: Acute Disease; Adolescent; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver I | 2002 |
Misuse of ecstasy.
Topics: 3,4-Methylenedioxyamphetamine; Acute Disease; Adult; Chemical and Drug Induced Liver Injury; Designe | 1992 |
Misuse of ecstasy.
Topics: 3,4-Methylenedioxyamphetamine; Acute Disease; Adult; Chemical and Drug Induced Liver Injury; Designe | 1992 |