n-methyl-3,4-methylenedioxyamphetamine has been researched along with Body Weight in 41 studies
N-Methyl-3,4-methylenedioxyamphetamine: An N-substituted amphetamine analog. It is a widely abused drug classified as a hallucinogen and causes marked, long-lasting changes in brain serotonergic systems. It is commonly referred to as MDMA or ecstasy.
3,4-methylenedioxymethamphetamine : A member of the class of benzodioxoles that is 1,3-benzodioxole substituted by a 2-(methylamino)propyl group at position 5.
Body Weight: The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fluoxetine treatment reversed MDMA-induced anxiety in the emergence test and depressive-like effects in the forced swim test, yet exhibited no effects on the social interaction test." | 5.32 | Chronic fluoxetine treatment partly attenuates the long-term anxiety and depressive symptoms induced by MDMA ('Ecstasy') in rats. ( Clemens, KJ; Cornish, JL; Gurtman, CG; Hunt, GE; Li, KM; McGregor, IS; Thompson, MR, 2004) |
| " However, evidence indicates that exposure to toxic doses of MDMA can lead to long-lasting dysregulation of brain monoaminergic neurotransmitters, primarily from studies conducted in young adult rodents." | 1.56 | The acute toxic and neurotoxic effects of 3,4-methylenedioxymethamphetamine are more pronounced in adolescent than adult mice. ( Bagwell, MS; Chitre, NM; Murnane, KS, 2020) |
| "Nicotine or MDMA treatment reduced memory function and altered hippocampal structure." | 1.43 | Neural and behavioural changes in male periadolescent mice after prolonged nicotine-MDMA treatment. ( Adeniyi, PA; Bankole, OO; Ishola, AO; Laoye, BJ; Ogundele, OM; Olatunji, BP; Shallie, PD, 2016) |
| "While hippocampus is a brain region particularly susceptible to the effects of MDMA, the cellular and molecular changes induced by MDMA are still to be fully elucidated, being the dosage regimen, the species and the developmental stage under study great variables." | 1.42 | Chronic MDMA induces neurochemical changes in the hippocampus of adolescent and young adult rats: Down-regulation of apoptotic markers. ( García-Cabrerizo, R; García-Fuster, MJ, 2015) |
| "These results suggest that MDMA treatment during pregnancy and lactation causes growth retardation and dysfunction of motor neurons in mouse pups." | 1.40 | Maternal MDMA administration in mice leads to neonatal growth delay. ( Kaizaki, A; Numazawa, S; Tanaka, S; Yoshida, T, 2014) |
| " Levels of MDMA and metabolites in plasma were measured in the same animals (n = 3) after dosing on a separate occasion." | 1.39 | Behavioral effects and pharmacokinetics of (±)-3,4-methylenedioxymethamphetamine (MDMA, Ecstasy) after intragastric administration to baboons. ( Ator, NA; Goodwin, AK; Mueller, M; Ricaurte, GA; Shell, CD, 2013) |
| " THC unexpectedly produced a modest hyperthermic effect when administered alone, but in animals co-treated with both THC and MDMA, there was an attenuation of MDMA-induced hyperthermia on dosing days." | 1.37 | Chronic administration of THC prevents the behavioral effects of intermittent adolescent MDMA administration and attenuates MDMA-induced hyperthermia and neurotoxicity in rats. ( Ali, SF; Meyer, JS; Shen, EY, 2011) |
| " Locomotor activity and body weight were assessed during the dosing period and withdrawal-related anxiety was assessed 24 h after drug cessation." | 1.36 | Residual social, memory and oxytocin-related changes in rats following repeated exposure to γ-hydroxybutyrate (GHB), 3,4-methylenedioxymethamphetamine (MDMA) or their combination. ( Arnold, JC; Hunt, GE; Long, LE; McGregor, IS; van Nieuwenhuijzen, PS, 2010) |
| " Regardless of dosing regimen, MDMA treatment produced path integration deficits as evidenced by an increase in latency to find the goal in the Cincinnati water maze." | 1.35 | (+/-)-3,4-Methylenedioxymethamphetamine treatment in adult rats impairs path integration learning: a comparison of single vs once per week treatment for 5 weeks. ( Able, JA; Grace, CE; Gudelsky, GA; Herring, NR; Schaefer, TL; Skelton, MR; Vorhees, CV; Williams, MT, 2008) |
| " The 3 highest MDMA dose groups showed reduced locomotor activity during the first 10 min (of 60 min), especially in the PD 1-5 and 6-10 dosing regimens." | 1.35 | (+/-)3,4-Methylenedioxymethamphetamine (MDMA) dose-dependently impairs spatial learning in the morris water maze after exposure of rats to different five-day intervals from birth to postnatal day twenty. ( Grace, CE; Herring, NR; Schaefer, TL; Skelton, MR; Vorhees, CV; Williams, MT, 2009) |
| "Citalopram pretreatment blocked MDMA-related reductions in aggressive and exploratory behavior measured in the social interaction and hole-board tests respectively." | 1.35 | Dissociation of the neurochemical and behavioral toxicology of MDMA ('Ecstasy') by citalopram. ( Ali, SF; Fraiman, JB; Meyer, JS; Owens, CB; Piper, BJ, 2008) |
| "Body weight was quantified immediately before each injection, and 2 h after the last injection, while core temperature and locomotor activity were continuously monitored via radiotelemetry." | 1.35 | A comparison of the physiological, behavioral, neurochemical and microglial effects of methamphetamine and 3,4-methylenedioxymethamphetamine in the mouse. ( Ciullo, JR; De La Garza, R; Fantegrossi, WE; Traynor, JR; Wakabayashi, KT; Woods, JH, 2008) |
| " The effects were seen when the drug was administered twice per day, but the optimal dosing regimen is unknown." | 1.34 | Developmental effects of +/-3,4-methylenedioxymethamphetamine on spatial versus path integration learning: effects of dose distribution. ( Schaefer, TL; Vorhees, CV; Williams, MT, 2007) |
| "Corticosterone was increased after the first dose and remained increased for at least 24 h, and returned to baseline by 30 h." | 1.33 | 3,4-Methylenedioxymethamphetamine administration on postnatal day 11 in rats increases pituitary-adrenal output and reduces striatal and hippocampal serotonin without altering SERT activity. ( Able, JA; Ehrman, LA; Gudelsky, GA; Sah, R; Schaefer, TL; Vorhees, CV; Williams, MT, 2005) |
| "Fluoxetine treatment reversed MDMA-induced anxiety in the emergence test and depressive-like effects in the forced swim test, yet exhibited no effects on the social interaction test." | 1.32 | Chronic fluoxetine treatment partly attenuates the long-term anxiety and depressive symptoms induced by MDMA ('Ecstasy') in rats. ( Clemens, KJ; Cornish, JL; Gurtman, CG; Hunt, GE; Li, KM; McGregor, IS; Thompson, MR, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (7.32) | 18.7374 |
| 1990's | 4 (9.76) | 18.2507 |
| 2000's | 18 (43.90) | 29.6817 |
| 2010's | 15 (36.59) | 24.3611 |
| 2020's | 1 (2.44) | 2.80 |
| Authors | Studies |
|---|---|
| Chitre, NM | 1 |
| Bagwell, MS | 1 |
| Murnane, KS | 1 |
| Goodwin, AK | 1 |
| Mueller, M | 1 |
| Shell, CD | 1 |
| Ricaurte, GA | 1 |
| Ator, NA | 1 |
| Abad, S | 1 |
| Fole, A | 1 |
| del Olmo, N | 1 |
| Pubill, D | 2 |
| Pallàs, M | 2 |
| Junyent, F | 1 |
| Camarasa, J | 2 |
| Camins, A | 2 |
| Escubedo, E | 2 |
| Kaizaki, A | 1 |
| Tanaka, S | 1 |
| Yoshida, T | 1 |
| Numazawa, S | 1 |
| Piper, BJ | 4 |
| Henderson, CS | 1 |
| Meyer, JS | 5 |
| Kwack, SJ | 1 |
| Yoon, KS | 1 |
| Lim, SK | 1 |
| Gwak, HM | 1 |
| Kim, JY | 1 |
| Um, YM | 1 |
| Lee, JD | 1 |
| Hyeon, JH | 1 |
| Kim, YJ | 1 |
| Kim, HS | 1 |
| Lee, BM | 1 |
| García-Cabrerizo, R | 1 |
| García-Fuster, MJ | 1 |
| Adeniyi, PA | 1 |
| Ishola, AO | 1 |
| Laoye, BJ | 1 |
| Olatunji, BP | 1 |
| Bankole, OO | 1 |
| Shallie, PD | 1 |
| Ogundele, OM | 1 |
| Skelton, MR | 7 |
| Able, JA | 2 |
| Grace, CE | 6 |
| Herring, NR | 4 |
| Schaefer, TL | 9 |
| Gudelsky, GA | 3 |
| Vorhees, CV | 9 |
| Williams, MT | 9 |
| Alves, E | 1 |
| Binienda, Z | 1 |
| Carvalho, F | 1 |
| Alves, CJ | 1 |
| Fernandes, E | 1 |
| de Lourdes Bastos, M | 1 |
| Tavares, MA | 1 |
| Summavielle, T | 1 |
| Adori, C | 2 |
| Zelena, D | 1 |
| Tímár, J | 1 |
| Gyarmati, Z | 1 |
| Domokos, A | 1 |
| Sobor, M | 1 |
| Fürst, Z | 1 |
| Makara, G | 1 |
| Bagdy, G | 2 |
| Vanattou-Saïfoudine, N | 1 |
| McNamara, R | 1 |
| Harkin, A | 1 |
| van Nieuwenhuijzen, PS | 1 |
| Long, LE | 1 |
| Hunt, GE | 2 |
| Arnold, JC | 1 |
| McGregor, IS | 2 |
| He, E | 1 |
| Graham, DL | 3 |
| Braun, AA | 3 |
| Amos-Kroohs, R | 1 |
| Andó, RD | 1 |
| Szekeres, M | 1 |
| Gutknecht, L | 1 |
| Kovács, GG | 1 |
| Hunyady, L | 1 |
| Lesch, KP | 1 |
| Burns, LN | 1 |
| Amos-Kroohs, RM | 2 |
| Shen, EY | 1 |
| Ali, SF | 2 |
| Canudas, AM | 1 |
| Thompson, MR | 1 |
| Li, KM | 1 |
| Clemens, KJ | 1 |
| Gurtman, CG | 1 |
| Cornish, JL | 1 |
| Conductier, G | 1 |
| Crosson, C | 1 |
| Hen, R | 1 |
| Bockaert, J | 1 |
| Compan, V | 1 |
| Ehrman, LA | 1 |
| Sah, R | 1 |
| Fraiman, JB | 2 |
| Vu, HL | 1 |
| Safain, MG | 1 |
| Oliver, AJ | 1 |
| Curran, HV | 1 |
| Robjant, K | 1 |
| Owens, CB | 1 |
| Diller, AJ | 1 |
| Rocha, A | 1 |
| Cardon, AL | 1 |
| Valles, R | 1 |
| Wellman, PJ | 1 |
| Nation, JR | 1 |
| Kobeissy, FH | 1 |
| Jeung, JA | 1 |
| Warren, MW | 1 |
| Geier, JE | 1 |
| Gold, MS | 1 |
| Fantegrossi, WE | 1 |
| Ciullo, JR | 1 |
| Wakabayashi, KT | 1 |
| De La Garza, R | 1 |
| Traynor, JR | 1 |
| Woods, JH | 1 |
| Bronson, ME | 2 |
| Barrios-Zambrano, L | 1 |
| Jiang, W | 2 |
| Clark, CR | 2 |
| DeRuiter, J | 2 |
| Newland, MC | 1 |
| Colado, MI | 1 |
| O'Shea, E | 1 |
| Granados, R | 1 |
| Misra, A | 1 |
| Murray, TK | 1 |
| Green, AR | 1 |
| Kalia, M | 1 |
| O'Callaghan, JP | 1 |
| Miller, DB | 1 |
| Kramer, M | 1 |
| Bilsky, EJ | 1 |
| Hui, YZ | 1 |
| Hubbell, CL | 1 |
| Reid, LD | 1 |
| Insel, TR | 1 |
| Battaglia, G | 1 |
| Johannessen, JN | 1 |
| Marra, S | 1 |
| De Souza, EB | 1 |
| Frith, CH | 1 |
| Chang, LW | 1 |
| Lattin, DL | 1 |
| Walls, RC | 1 |
| Hamm, J | 1 |
| Doblin, R | 1 |
| Nencini, P | 1 |
| Woolverton, WL | 1 |
| Seiden, LS | 1 |
41 other studies available for n-methyl-3,4-methylenedioxyamphetamine and Body Weight
| Article | Year |
|---|---|
The acute toxic and neurotoxic effects of 3,4-methylenedioxymethamphetamine are more pronounced in adolescent than adult mice.
Topics: 3,4-Dihydroxyphenylacetic Acid; Age Factors; Animals; Body Weight; Central Nervous System Stimulants | 2020 |
Behavioral effects and pharmacokinetics of (±)-3,4-methylenedioxymethamphetamine (MDMA, Ecstasy) after intragastric administration to baboons.
Topics: Animals; Behavior, Animal; Biotransformation; Body Weight; Conditioning, Operant; Dose-Response Rela | 2013 |
MDMA enhances hippocampal-dependent learning and memory under restrictive conditions, and modifies hippocampal spine density.
Topics: Animals; Body Temperature; Body Weight; CA1 Region, Hippocampal; Dendritic Spines; Male; Maze Learni | 2014 |
Maternal MDMA administration in mice leads to neonatal growth delay.
Topics: Animals; Behavior, Animal; Body Weight; Female; Gestational Age; Growth and Development; Illicit Dru | 2014 |
Adolescent MDMA exposure diminishes the physiological and neurotoxic consequences of an MDMA binge in female rats.
Topics: Animals; Body Temperature; Body Weight; Cerebral Cortex; Female; Male; Motor Activity; N-Methyl-3,4- | 2014 |
A one-generation reproductive toxicity study of 3,4-methylenedioxy-n-methamphetamine (MDMA, Ecstasy), an amphetamine derivative, in C57BL/6 mice.
Topics: Animals; Body Weight; Brain; Dose-Response Relationship, Drug; Female; Kidney; Lactation; Liver; Mal | 2014 |
Chronic MDMA induces neurochemical changes in the hippocampus of adolescent and young adult rats: Down-regulation of apoptotic markers.
Topics: Aging; Animals; Animals, Newborn; Apoptosis; bcl-2-Associated X Protein; Body Temperature; Body Weig | 2015 |
Neural and behavioural changes in male periadolescent mice after prolonged nicotine-MDMA treatment.
Topics: Animals; Behavior, Animal; Body Weight; Drug Interactions; Hallucinogens; Hippocampus; Lipid Peroxid | 2016 |
(+/-)-3,4-Methylenedioxymethamphetamine treatment in adult rats impairs path integration learning: a comparison of single vs once per week treatment for 5 weeks.
Topics: Animals; Anxiety; Behavior, Animal; Body Temperature; Body Weight; Hallucinogens; Learning; Male; Ma | 2008 |
Acetyl-L-carnitine provides effective in vivo neuroprotection over 3,4-methylenedioximethamphetamine-induced mitochondrial neurotoxicity in the adolescent rat brain.
Topics: Acetylcarnitine; Animals; Body Weight; Brain; Cyclooxygenase 1; DNA, Mitochondrial; Fever; Hallucino | 2009 |
Comparison of the developmental effects of 5-methoxy-N,N-diisopropyltryptamine (Foxy) to (+/-)-3,4-methylenedioxymethamphetamine (ecstasy) in rats.
Topics: Aging; Animals; Anxiety; Body Weight; Cues; Female; Hallucinogens; Learning; Lighting; Maze Learning | 2009 |
(+/-)3,4-Methylenedioxymethamphetamine (MDMA) dose-dependently impairs spatial learning in the morris water maze after exposure of rats to different five-day intervals from birth to postnatal day twenty.
Topics: Aging; Animals; Animals, Newborn; Body Weight; Cues; Dose-Response Relationship, Drug; Female; Hallu | 2009 |
Intermittent prenatal MDMA exposure alters physiological but not mood related parameters in adult rat offspring.
Topics: Adrenocorticotropic Hormone; Animals; Anxiety; Behavior, Animal; Blood Glucose; Body Weight; Corpus | 2010 |
Caffeine promotes dopamine D1 receptor-mediated body temperature, heart rate and behavioural responses to MDMA ('ecstasy').
Topics: Analysis of Variance; Animals; Behavior, Animal; Benzazepines; Body Weight; Caffeine; Central Nervou | 2010 |
Residual social, memory and oxytocin-related changes in rats following repeated exposure to γ-hydroxybutyrate (GHB), 3,4-methylenedioxymethamphetamine (MDMA) or their combination.
Topics: Animals; Anxiety; Behavior, Animal; Biogenic Monoamines; Body Weight; Brain; Chromatography, High Pr | 2010 |
Comparison of (+)-methamphetamine, ±-methylenedioxymethamphetamine, (+)-amphetamine and ±-fenfluramine in rats on egocentric learning in the Cincinnati water maze.
Topics: Amphetamine; Analysis of Variance; Animals; Behavior, Animal; Body Temperature; Body Weight; Central | 2011 |
Recovery and aging of serotonergic fibers after single and intermittent MDMA treatment in Dark Agouti rat.
Topics: Adolescent; Adult; Aging; Animals; Body Temperature; Body Weight; Brain; Brain-Derived Neurotrophic | 2011 |
Distinct periods of developmental sensitivity to the effects of 3,4-(±)-methylenedioxymethamphetamine (MDMA) on behaviour and monoamines in rats.
Topics: Acoustic Stimulation; Aging; Animals; Animals, Newborn; Behavior, Animal; Biogenic Monoamines; Body | 2012 |
Chronic administration of THC prevents the behavioral effects of intermittent adolescent MDMA administration and attenuates MDMA-induced hyperthermia and neurotoxicity in rats.
Topics: Adrenergic Uptake Inhibitors; Age Factors; Analysis of Variance; Animals; Animals, Newborn; Behavior | 2011 |
Cognitive impairments from developmental exposure to serotonergic drugs: citalopram and MDMA.
Topics: Animals; Animals, Newborn; Body Weight; Citalopram; Cognition Disorders; Disease Models, Animal; Fem | 2013 |
Different glial response to methamphetamine- and methylenedioxymethamphetamine-induced neurotoxicity.
Topics: Animals; Binding Sites; Body Weight; Brain; Carrier Proteins; Central Nervous System Diseases; Dopam | 2003 |
Chronic fluoxetine treatment partly attenuates the long-term anxiety and depressive symptoms induced by MDMA ('Ecstasy') in rats.
Topics: Animals; Antidepressive Agents, Second-Generation; Anxiety; Body Fluids; Body Temperature; Body Weig | 2004 |
3,4-N-methlenedioxymethamphetamine-induced hypophagia is maintained in 5-HT1B receptor knockout mice, but suppressed by the 5-HT2C receptor antagonist RS102221.
Topics: Animals; Body Weight; Eating; Hallucinogens; Kinetics; Male; Mice; Mice, Knockout; N-Methyl-3,4-meth | 2005 |
3,4-Methylenedioxymethamphetamine administration on postnatal day 11 in rats increases pituitary-adrenal output and reduces striatal and hippocampal serotonin without altering SERT activity.
Topics: Adrenocorticotropic Hormone; Age Factors; Analysis of Variance; Animals; Animals, Newborn; Body Weig | 2005 |
Repeated MDMA ("Ecstasy") exposure in adolescent male rats alters temperature regulation, spontaneous motor activity, attention, and serotonin transporter binding.
Topics: Analysis of Variance; Animals; Attention; Body Temperature; Body Temperature Regulation; Body Weight | 2005 |
Repeated adolescent 3,4-methylenedioxymethamphetamine (MDMA) exposure in rats attenuates the effects of a subsequent challenge with MDMA or a 5-hydroxytryptamine(1A) receptor agonist.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Animals; Behavior, Animal; Body Weight; Dose-Response | 2006 |
Eating attitudes, weight concerns and beliefs about drug effects in women who use ecstasy.
Topics: Adolescent; Adult; Amphetamine-Related Disorders; Appetite; Attitude to Health; Body Image; Body Wei | 2006 |
Developmental effects of +/-3,4-methylenedioxymethamphetamine on spatial versus path integration learning: effects of dose distribution.
Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Behavior, Animal; Body Weight; Dose-Re | 2007 |
Dissociation of the neurochemical and behavioral toxicology of MDMA ('Ecstasy') by citalopram.
Topics: Analysis of Variance; Animals; Behavior, Animal; Body Temperature; Body Weight; Brain Chemistry; Cit | 2008 |
The effects of concurrent administration of +/-3,4-methylenedioxymethamphetamine and cocaine on conditioned place preference in the adult male rat.
Topics: Animals; Body Weight; Choice Behavior; Cocaine; Conditioning, Operant; Dose-Response Relationship, D | 2007 |
Changes in leptin, ghrelin, growth hormone and neuropeptide-Y after an acute model of MDMA and methamphetamine exposure in rats.
Topics: Adrenergic Uptake Inhibitors; Amphetamine-Related Disorders; Animals; Appetite; Body Weight; Disease | 2008 |
Short- and long-term effects of (+)-methamphetamine and (+/-)-3,4-methylenedioxymethamphetamine on monoamine and corticosterone levels in the neonatal rat following multiple days of treatment.
Topics: Adrenergic Uptake Inhibitors; Animals; Animals, Newborn; Biogenic Monoamines; Body Weight; Corticost | 2008 |
A comparison of the physiological, behavioral, neurochemical and microglial effects of methamphetamine and 3,4-methylenedioxymethamphetamine in the mouse.
Topics: Animals; Behavior, Animal; Body Temperature; Body Weight; Brain; Brain Chemistry; Central Nervous Sy | 2008 |
Behavioral and developmental effects of two 3,4-methylenedioxymethamphetamine (MDMA) derivatives.
Topics: 3,4-Methylenedioxyamphetamine; Abnormalities, Drug-Induced; Animals; Appetitive Behavior; Arousal; B | 1994 |
Effects of designer drugs on the chicken embryo and 1-day-old chicken.
Topics: 3,4-Methylenedioxyamphetamine; Animals; Animals, Newborn; Body Weight; Chick Embryo; Chickens; Desig | 1994 |
A study of the neurotoxic effect of MDMA ('ecstasy') on 5-HT neurones in the brains of mothers and neonates following administration of the drug during pregnancy.
Topics: Animals; Body Temperature; Body Weight; Brain; Dopamine; Female; Hydroxyindoleacetic Acid; Lipid Per | 1997 |
Comparative study of fluoxetine, sibutramine, sertraline and dexfenfluramine on the morphology of serotonergic nerve terminals using serotonin immunohistochemistry.
Topics: Animals; Appetite Depressants; Body Weight; Cyclobutanes; Dexfenfluramine; Eating; Fluoxetine; Immun | 2000 |
Methylenedioxymethamphetamine's capacity to establish place preferences and modify intake of an alcoholic beverage.
Topics: 3,4-Methylenedioxyamphetamine; Alcohol Drinking; Animals; Body Weight; Conditioning, Operant; Dose-R | 1990 |
3,4-Methylenedioxymethamphetamine ("ecstasy") selectively destroys brain serotonin terminals in rhesus monkeys.
Topics: 3,4-Methylenedioxyamphetamine; Amphetamines; Animals; Behavior, Animal; Body Weight; Brain Chemistry | 1989 |
Toxicity of methylenedioxymethamphetamine (MDMA) in the dog and the rat.
Topics: 3,4-Methylenedioxyamphetamine; Amphetamines; Animals; Body Weight; Brain; Dogs; Eating; Female; Male | 1987 |
Enhancement of morphine-induced analgesia after repeated injections of methylenedioxymethamphetamine.
Topics: 3,4-Methylenedioxyamphetamine; Amphetamines; Analgesia; Animals; Body Weight; Catecholamines; Centra | 1988 |