n-methyl-3,4-methylenedioxyamphetamine has been researched along with Aging in 25 studies
N-Methyl-3,4-methylenedioxyamphetamine: An N-substituted amphetamine analog. It is a widely abused drug classified as a hallucinogen and causes marked, long-lasting changes in brain serotonergic systems. It is commonly referred to as MDMA or ecstasy.
3,4-methylenedioxymethamphetamine : A member of the class of benzodioxoles that is 1,3-benzodioxole substituted by a 2-(methylamino)propyl group at position 5.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The present study aimed to evaluate the differential toxic effects of MDMA in adolescent and aged Wistar rats, using doses pharmacologically comparable to humans." | 1.48 | Aged rats are more vulnerable than adolescents to "ecstasy"-induced toxicity. ( Barbosa, DJ; Bastos, ML; Capela, JP; Carvalho, F; Costa, VM; Duarte, JA; Duarte-Araújo, M; Feio-Azevedo, R; Fernandes, E; Gomes, S; Marques, F; Pereira, FC; Pita, I; Teixeira-Gomes, A, 2018) |
| "While hippocampus is a brain region particularly susceptible to the effects of MDMA, the cellular and molecular changes induced by MDMA are still to be fully elucidated, being the dosage regimen, the species and the developmental stage under study great variables." | 1.42 | Chronic MDMA induces neurochemical changes in the hippocampus of adolescent and young adult rats: Down-regulation of apoptotic markers. ( García-Cabrerizo, R; García-Fuster, MJ, 2015) |
| " The 3 highest MDMA dose groups showed reduced locomotor activity during the first 10 min (of 60 min), especially in the PD 1-5 and 6-10 dosing regimens." | 1.35 | (+/-)3,4-Methylenedioxymethamphetamine (MDMA) dose-dependently impairs spatial learning in the morris water maze after exposure of rats to different five-day intervals from birth to postnatal day twenty. ( Grace, CE; Herring, NR; Schaefer, TL; Skelton, MR; Vorhees, CV; Williams, MT, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (4.00) | 18.2507 |
| 2000's | 10 (40.00) | 29.6817 |
| 2010's | 14 (56.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Feio-Azevedo, R | 1 |
| Costa, VM | 1 |
| Barbosa, DJ | 1 |
| Teixeira-Gomes, A | 1 |
| Pita, I | 1 |
| Gomes, S | 1 |
| Pereira, FC | 1 |
| Duarte-Araújo, M | 1 |
| Duarte, JA | 1 |
| Marques, F | 1 |
| Fernandes, E | 1 |
| Bastos, ML | 1 |
| Carvalho, F | 1 |
| Capela, JP | 1 |
| Montagud-Romero, S | 1 |
| Daza-Losada, M | 2 |
| Vidal-Infer, A | 1 |
| Maldonado, C | 2 |
| Aguilar, MA | 3 |
| Miñarro, J | 3 |
| Rodríguez-Arias, M | 3 |
| García-Pardo, MP | 1 |
| Manzanedo, C | 2 |
| García-Cabrerizo, R | 2 |
| García-Fuster, MJ | 2 |
| Frau, L | 2 |
| Costa, G | 1 |
| Porceddu, PF | 2 |
| Khairnar, A | 1 |
| Castelli, MP | 1 |
| Ennas, MG | 1 |
| Madeddu, C | 1 |
| Wardas, J | 1 |
| Morelli, M | 2 |
| Abad, S | 1 |
| Camarasa, J | 1 |
| Pubill, D | 1 |
| Camins, A | 1 |
| Escubedo, E | 1 |
| Simola, N | 1 |
| Skelton, MR | 3 |
| Schaefer, TL | 3 |
| Herring, NR | 2 |
| Grace, CE | 3 |
| Vorhees, CV | 3 |
| Williams, MT | 3 |
| Piper, BJ | 2 |
| Farelli, JD | 1 |
| Meyer, JS | 3 |
| Arias-Cavieres, A | 1 |
| Rozas, C | 1 |
| Reyes-Parada, M | 1 |
| Barrera, N | 1 |
| Pancetti, F | 1 |
| Loyola, S | 1 |
| Lorca, RA | 1 |
| Zeise, ML | 1 |
| Morales, B | 1 |
| Walker, QD | 1 |
| Morris, SE | 1 |
| Arrant, AE | 1 |
| Nagel, JM | 1 |
| Parylak, S | 1 |
| Zhou, G | 1 |
| Caster, JM | 1 |
| Kuhn, CM | 1 |
| Adori, C | 1 |
| Andó, RD | 1 |
| Szekeres, M | 1 |
| Gutknecht, L | 1 |
| Kovács, GG | 1 |
| Hunyady, L | 1 |
| Lesch, KP | 1 |
| Bagdy, G | 1 |
| Graham, DL | 1 |
| Braun, AA | 1 |
| Burns, LN | 1 |
| Amos-Kroohs, RM | 1 |
| Llorente-Berzal, A | 1 |
| Valero, M | 1 |
| López-Gallardo, M | 1 |
| Viveros, MP | 1 |
| Kolyaduke, OV | 1 |
| Hughes, RN | 1 |
| Morley-Fletcher, S | 1 |
| Bianchi, M | 1 |
| Gerra, G | 1 |
| Laviola, G | 1 |
| Reveron, ME | 1 |
| Monks, TJ | 1 |
| Duvauchelle, CL | 1 |
| Vu, HL | 1 |
| Safain, MG | 1 |
| Oliver, AJ | 1 |
| Fisk, JE | 1 |
| Montgomery, C | 1 |
| Wareing, M | 1 |
| Murphy, PN | 1 |
| Kindlundh-Högberg, AM | 2 |
| Schiöth, HB | 2 |
| Svenningsson, P | 1 |
| Blomqvist, A | 1 |
| Malki, R | 1 |
| Broening, HW | 1 |
| Bowyer, JF | 1 |
| Slikker, W | 1 |
| Ali, SF | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effects of MDMA on Prefrontal and Amygdala Activation in Posttraumatic Stress Disorder[NCT03752918] | Phase 1 | 20 participants (Anticipated) | Interventional | 2024-01-31 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
25 other studies available for n-methyl-3,4-methylenedioxyamphetamine and Aging
| Article | Year |
|---|---|
Aged rats are more vulnerable than adolescents to "ecstasy"-induced toxicity.
Topics: Aging; Animals; Brain; Dopamine; Fever; Heart; Liver; Male; N-Methyl-3,4-methylenedioxyamphetamine; | 2018 |
The novelty-seeking phenotype modulates the long-lasting effects of intermittent ethanol administration during adolescence.
Topics: Adolescent; Aging; Animals; Anxiety; Behavior, Animal; Cocaine; Ethanol; Exploratory Behavior; Human | 2014 |
Effects of acute social stress on the conditioned place preference induced by MDMA in adolescent and adult mice.
Topics: Aging; Animals; Anxiety; Conditioning, Psychological; Corticosterone; Dominance-Subordination; Dose- | 2014 |
Chronic MDMA induces neurochemical changes in the hippocampus of adolescent and young adult rats: Down-regulation of apoptotic markers.
Topics: Aging; Animals; Animals, Newborn; Apoptosis; bcl-2-Associated X Protein; Body Temperature; Body Weig | 2015 |
Influence of caffeine on 3,4-methylenedioxymethamphetamine-induced dopaminergic neuron degeneration and neuroinflammation is age-dependent.
Topics: Age Factors; Aging; Animals; Caffeine; Dopaminergic Neurons; Drug Synergism; Inflammation; Male; Mic | 2016 |
Adaptive Plasticity in the Hippocampus of Young Mice Intermittently Exposed to MDMA Could Be the Origin of Memory Deficits.
Topics: Aging; Animals; Biomarkers; Brain-Derived Neurotrophic Factor; Hippocampus; Male; Memory; Memory Dis | 2016 |
Comparative effects of amphetamine-like psychostimulants on rat hippocampal cell genesis at different developmental ages.
Topics: Age Factors; Aging; Amphetamine; Animals; Brain-Derived Neurotrophic Factor; Bromodeoxyuridine; Cent | 2016 |
Effect of crowding, temperature and age on glia activation and dopaminergic neurotoxicity induced by MDMA in the mouse brain.
Topics: Aging; Analysis of Variance; Animals; Body Temperature; CD11b Antigen; Crowding; Disease Models, Ani | 2016 |
Comparison of the developmental effects of 5-methoxy-N,N-diisopropyltryptamine (Foxy) to (+/-)-3,4-methylenedioxymethamphetamine (ecstasy) in rats.
Topics: Aging; Animals; Anxiety; Body Weight; Cues; Female; Hallucinogens; Learning; Lighting; Maze Learning | 2009 |
Dissociation between serotonin neurotoxicity and brain-derived neurotrophic factor induction following neonatal MDMA exposure in rats.
Topics: Aging; Animals; Animals, Newborn; Brain Chemistry; Brain-Derived Neurotrophic Factor; Cerebral Corte | 2009 |
(+/-)3,4-Methylenedioxymethamphetamine (MDMA) dose-dependently impairs spatial learning in the morris water maze after exposure of rats to different five-day intervals from birth to postnatal day twenty.
Topics: Aging; Animals; Animals, Newborn; Body Weight; Cues; Dose-Response Relationship, Drug; Female; Hallu | 2009 |
MDMA ("ecstasy") impairs learning in the Morris Water Maze and reduces hippocampal LTP in young rats.
Topics: Aging; Animals; CA1 Region, Hippocampal; Central Nervous System Stimulants; Dose-Response Relationsh | 2010 |
Dopamine uptake inhibitors but not dopamine releasers induce greater increases in motor behavior and extracellular dopamine in adolescent rats than in adult male rats.
Topics: Aging; Amphetamines; Animals; Behavior, Animal; Brain Chemistry; Dopamine; Dopamine Uptake Inhibitor | 2010 |
Recovery and aging of serotonergic fibers after single and intermittent MDMA treatment in Dark Agouti rat.
Topics: Adolescent; Adult; Aging; Animals; Body Temperature; Body Weight; Brain; Brain-Derived Neurotrophic | 2011 |
Distinct periods of developmental sensitivity to the effects of 3,4-(±)-methylenedioxymethamphetamine (MDMA) on behaviour and monoamines in rats.
Topics: Acoustic Stimulation; Aging; Animals; Animals, Newborn; Behavior, Animal; Biogenic Monoamines; Body | 2012 |
Sex-dependent effects of early maternal deprivation on MDMA-induced conditioned place preference in adolescent rats: possible neurochemical correlates.
Topics: Aging; Animals; Brain; Brain Chemistry; Conditioning, Classical; Female; Male; Maternal Deprivation; | 2013 |
Increased anxiety-related behavior in male and female adult rats following early and late adolescent exposure to 3,4-methylenedioxymethamphetamine (MDMA).
Topics: Age Factors; Aging; Animals; Anxiety; Female; Male; Maze Learning; N-Methyl-3,4-methylenedioxyamphet | 2013 |
Acute and carryover effects in mice of MDMA ("ecstasy") administration during periadolescence.
Topics: Aging; Animals; Behavior, Animal; Female; Hallucinogens; Hypothalamus; Locomotion; Male; Mice; N-Met | 2002 |
Age-dependent (+)MDMA-mediated neurotoxicity in mice.
Topics: Aging; Animals; Body Temperature; Brain; Dopamine Plasma Membrane Transport Proteins; Fever; Halluci | 2005 |
Repeated adolescent 3,4-methylenedioxymethamphetamine (MDMA) exposure in rats attenuates the effects of a subsequent challenge with MDMA or a 5-hydroxytryptamine(1A) receptor agonist.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Animals; Behavior, Animal; Body Weight; Dose-Response | 2006 |
The effects of concurrent cannabis use among ecstasy users: neuroprotective or neurotoxic?
Topics: Age Factors; Aging; Cognition; Drug Interactions; Educational Status; Female; Hallucinogens; Humans; | 2006 |
Repeated intermittent MDMA binges reduce DAT density in mice and SERT density in rats in reward regions of the adolescent brain.
Topics: Age Factors; Aging; Animals; Autoradiography; Behavior, Animal; Brain; Central Nervous System Stimul | 2007 |
Extensive neuroadaptive changes in cortical gene-transcript expressions of the glutamate system in response to repeated intermittent MDMA administration in adolescent rats.
Topics: Adaptation, Physiological; Adrenergic Uptake Inhibitors; Age Factors; Aging; Amphetamine-Related Dis | 2008 |
Age-dependent sensitivity of rats to the long-term effects of the serotonergic neurotoxicant (+/-)-3,4-methylenedioxymethamphetamine (MDMA) correlates with the magnitude of the MDMA-induced thermal response.
Topics: Aging; Animals; Body Temperature Regulation; Brain; Dose-Response Relationship, Drug; Female; Male; | 1995 |
Serotonergic neurotoxicity of MDMA (ecstasy) in the developing rat brain.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Animals; Apoptosis; Brain; Dopamine; Female; Homovanillic Aci | 2002 |