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n-methyl-3,4-methylenedioxyamphetamine and Aggression

n-methyl-3,4-methylenedioxyamphetamine has been researched along with Aggression in 27 studies

N-Methyl-3,4-methylenedioxyamphetamine: An N-substituted amphetamine analog. It is a widely abused drug classified as a hallucinogen and causes marked, long-lasting changes in brain serotonergic systems. It is commonly referred to as MDMA or ecstasy.
3,4-methylenedioxymethamphetamine : A member of the class of benzodioxoles that is 1,3-benzodioxole substituted by a 2-(methylamino)propyl group at position 5.

Aggression: Behavior which may be manifested by destructive and attacking action which is verbal or physical, by covert attitudes of hostility or by obstructionism.

Research Excerpts

ExcerptRelevanceReference
"Analysis of longitudinal data from a population-based sample of Australian young adult amphetamine-type stimulant users (n=248) to examine: (a) prevalence and timing of simultaneous alcohol and amphetamine-type stimulant use and (b) predictors of ecstasy- and methamphetamine-related aggression and hostility."7.85Simultaneous use of alcohol with methamphetamine but not ecstasy linked with aggression among young adult stimulant users. ( Cherney, A; Kemp, R; Legosz, M; Leslie, EM; Najman, JM; Smirnov, A; Wells, H, 2017)
"Analysis of longitudinal data from a population-based sample of Australian young adult amphetamine-type stimulant users (n=248) to examine: (a) prevalence and timing of simultaneous alcohol and amphetamine-type stimulant use and (b) predictors of ecstasy- and methamphetamine-related aggression and hostility."3.85Simultaneous use of alcohol with methamphetamine but not ecstasy linked with aggression among young adult stimulant users. ( Cherney, A; Kemp, R; Legosz, M; Leslie, EM; Najman, JM; Smirnov, A; Wells, H, 2017)
" The possibility that some of these psychological problems are caused by ecstasy-induced neurotoxicity is supported by preclinical evidence of MDMA-induced neurotoxicity and behavioural deficits, evidence of depleted serotonin in heavy ecstasy users, and by dose-response relationships between the extent of exposure to ecstasy and the severity of cognitive impairments."2.41Ecstasy (MDMA): a review of its possible persistent psychological effects. ( Morgan, MJ, 2000)
"Humans with genetic predisposition for the slow metabolism of MDMA, the so-called "poor metabolizers" of debrisoquin are at higher risk."1.36Long-term neuronal damage and recovery after a single dose of MDMA: expression and distribution of serotonin transporter in the rat brain. ( Kirilly, E, 2010)
" Fifteen MDMA users, who did not have other drug dependencies or alcohol abuse, and had not used other drugs for prolonged periods, and 15 control individuals were included in a study to assess the biological and psychological changes after chronic use of MDMA."1.30Serotonergic function after (+/-)3,4-methylene-dioxymethamphetamine ('Ecstasy') in humans. ( Caccavari, R; Delsignore, R; Gerra, G; Giucastro, G; Maestri, D; Monica, C; Sartori, R; Zaimovic, A, 1998)

Research

Studies (27)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (14.81)18.2507
2000's17 (62.96)29.6817
2010's6 (22.22)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Martín-López, M1
Muela, AT1
Cavas, M1
Navarro, JF2
Fulde, GW1
Forster, SL1
Leslie, EM1
Smirnov, A1
Cherney, A1
Wells, H1
Legosz, M1
Kemp, R1
Najman, JM1
Wallinga, AE2
ten Voorde, AM1
de Boer, SF2
Koolhaas, JM2
Buwalda, B2
Granneman, RA1
Wan, L1
Baldridge, RM1
Colby, AM1
Stanford, MS1
Kirilly, E2
Machalova, A1
Slais, K1
Vrskova, D1
Sulcova, A1
Rugani, F1
Bacciardi, S1
Rovai, L1
Pacini, M1
Maremmani, AG1
Deltito, J1
Dell'osso, L1
Maremmani, I1
Gerra, G3
Zaimovic, A3
Moi, G1
Giusti, F2
Gardini, S1
Delsignore, R3
Laviola, G2
Macchia, T2
Brambilla, F2
Bond, AJ2
Verheyden, SL3
Wingrove, J1
Curran, HV6
Rees, H1
Hoare, T1
Hoshi, R3
Bond, A2
Maidment, R1
Milani, RM1
Parrott, AC2
Schifano, F1
Turner, JJ1
Benko, A1
Ferrington, L1
Ando, RD1
Kelly, PA1
Bagdy, G1
Pratt, H1
Mehta, S1
Reid, LW1
Elifson, KW1
Sterk, CE1
Cohen, L1
Lemanski, L1
Piccini, P1
Miczek, KA1
Haney, M1
Giucastro, G1
Maestri, D1
Monica, C1
Sartori, R1
Caccavari, R1
Maldonado, E1
Scearce-Levie, K1
Chen, JP1
Gardner, E1
Hen, R1
Morgan, MJ1
McElrath, K1
McEvoy, K1
Ampollini, R1
Raggi, MA1
Hadfield, J1
Calin, T1

Reviews

2 reviews available for n-methyl-3,4-methylenedioxyamphetamine and Aggression

ArticleYear
The impact of amphetamine-type stimulants on emergency services.
    Current opinion in psychiatry, 2015, Volume: 28, Issue:4

    Topics: Acute Disease; Aggression; Amphetamine; Amphetamine-Related Disorders; Anxiety; Central Nervous Syst

2015
Ecstasy (MDMA): a review of its possible persistent psychological effects.
    Psychopharmacology, 2000, Volume: 152, Issue:3

    Topics: Affect; Aggression; Animals; Anxiety; Brain; Cognition Disorders; Humans; Memory; N-Methyl-3,4-methy

2000

Trials

4 trials available for n-methyl-3,4-methylenedioxyamphetamine and Aggression

ArticleYear
Effects of (+/-) 3,4-methylene-dioxymethamphetamine (ecstasy) on dopamine system function in humans.
    Behavioural brain research, 2002, Aug-21, Volume: 134, Issue:1-2

    Topics: Adolescent; Adult; Aggression; Bromocriptine; Depressive Disorder; Dopamine; Dopamine Agonists; Dopa

2002
Angry cognitive bias, trait aggression and impulsivity in substance users.
    Psychopharmacology, 2004, Volume: 171, Issue:3

    Topics: Aggression; Analysis of Variance; Anger; Cognition; Double-Blind Method; Humans; Impulsive Behavior;

2004
Pattern of cannabis use in ecstasy polydrug users: moderate cannabis use may compensate for self-rated aggression and somatic symptoms.
    Human psychopharmacology, 2005, Volume: 20, Issue:4

    Topics: Adult; Aggression; Alcohol Drinking; Cognition Disorders; Drug Interactions; Family; Female; Humans;

2005
An investigation into the sub-acute effects of ecstasy on aggressive interpretative bias and aggressive mood - are there gender differences?
    Journal of psychopharmacology (Oxford, England), 2006, Volume: 20, Issue:2

    Topics: Adult; Affect; Aggression; Alcoholic Intoxication; Amphetamine-Related Disorders; Anxiety; Attention

2006

Other Studies

21 other studies available for n-methyl-3,4-methylenedioxyamphetamine and Aggression

ArticleYear
Effects of para-methoxyamphetamine (PMA) on agonistic encounters between male mice.
    Pharmacology, biochemistry, and behavior, 2018, Volume: 167

    Topics: Aggression; Amphetamines; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Housing, Anim

2018
Simultaneous use of alcohol with methamphetamine but not ecstasy linked with aggression among young adult stimulant users.
    Addictive behaviors, 2017, Volume: 70

    Topics: Adult; Aggression; Alcohol Drinking; Australia; Central Nervous System Depressants; Central Nervous

2017
MDMA-induced serotonergic neurotoxicity enhances aggressiveness in low- but not high-aggressive rats.
    European journal of pharmacology, 2009, Sep-15, Volume: 618, Issue:1-3

    Topics: Aggression; Animals; Behavior, Animal; Drug Administration Schedule; Female; Immunohistochemistry; I

2009
Long-term neurobiological consequences of ecstasy: a role for pre-existing trait-like differences in brain monoaminergic functioning?
    Pharmacology, biochemistry, and behavior, 2009, Volume: 94, Issue:2

    Topics: Aggression; Animals; Biogenic Monoamines; Brain; Dopamine; Dose-Response Relationship, Drug; Female;

2009
Enhanced intensity dependence and aggression history indicate previous regular ecstasy use in abstinent polydrug users.
    Progress in neuro-psychopharmacology & biological psychiatry, 2009, Nov-13, Volume: 33, Issue:8

    Topics: Adult; Aggression; Analysis of Variance; Brain Mapping; Dichotic Listening Tests; Discrimination, Ps

2009
Long-term neuronal damage and recovery after a single dose of MDMA: expression and distribution of serotonin transporter in the rat brain.
    Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology, 2010, Volume: 12, Issue:3

    Topics: Aggression; Animals; Basal Metabolism; Brain; Gene Expression Regulation; Genetic Predisposition to

2010
Differential effects of modafinil, methamphetamine, and MDMA on agonistic behavior in male mice.
    Pharmacology, biochemistry, and behavior, 2012, Volume: 102, Issue:2

    Topics: Aggression; Animals; Behavior, Animal; Benzhydryl Compounds; Central Nervous System Stimulants; Dose

2012
Symptomatological features of patients with and without Ecstasy use during their first psychotic episode.
    International journal of environmental research and public health, 2012, Volume: 9, Issue:7

    Topics: Adolescent; Adult; Aggression; Discriminant Analysis; Hallucinogens; Humans; Male; N-Methyl-3,4-meth

2012
Empathy and aggression: two faces of ecstasy? A study of interpretative cognitive bias and mood change in ecstasy users.
    Psychopharmacology, 2004, Volume: 173, Issue:3-4

    Topics: Adult; Affect; Aggression; Bias; Cognition; Empathy; Female; Humans; Male; N-Methyl-3,4-methylenedio

2004
Quitting ecstasy: an investigation of why people stop taking the drug and their subsequent mental health.
    Journal of psychopharmacology (Oxford, England), 2003, Volume: 17, Issue:4

    Topics: Adult; Affect; Aggression; Amphetamine-Related Disorders; Anxiety; Decision Making; Hallucinogens; H

2003
Acute and long-term effects of a single dose of MDMA on aggression in Dark Agouti rats.
    The international journal of neuropsychopharmacology, 2006, Volume: 9, Issue:1

    Topics: Adrenergic Uptake Inhibitors; Aggression; Animals; Brain; Glucose; Male; N-Methyl-3,4-methylenedioxy

2006
Ecstasy versus alcohol: Tolstoy and the variations of unhappiness.
    Journal of psychopharmacology (Oxford, England), 2007, Volume: 21, Issue:1

    Topics: Affect; Aggression; Alcoholic Intoxication; Amphetamine-Related Disorders; Automobile Driving; Centr

2007
Hug drug or thug drug? Ecstasy use and aggressive behavior.
    Violence and victims, 2007, Volume: 22, Issue:1

    Topics: Adult; Affect; Aggression; Amphetamine-Related Disorders; Anxiety; Attention; Concept Formation; Dep

2007
Ecstasy (MDMA) does not have long-term effects on aggressive interpretative bias: a study comparing current and ex-ecstasy users with polydrug and drug-naive controls.
    Experimental and clinical psychopharmacology, 2007, Volume: 15, Issue:4

    Topics: Adult; Affect; Aggression; Analysis of Variance; Bias; Employment; Female; Hallucinogens; Humans; Ma

2007
Psychomotor stimulant effects of d-amphetamine, MDMA and PCP: aggressive and schedule-controlled behavior in mice.
    Psychopharmacology, 1994, Volume: 115, Issue:3

    Topics: Aggression; Animals; Central Nervous System Stimulants; Conditioning, Operant; Dextroamphetamine; Do

1994
Serotonergic function after (+/-)3,4-methylene-dioxymethamphetamine ('Ecstasy') in humans.
    International clinical psychopharmacology, 1998, Volume: 13, Issue:1

    Topics: Adolescent; Adult; Affect; Aggression; Exploratory Behavior; Fenfluramine; Hallucinogens; Humans; Hy

1998
Behavioral profile of 3,4-methylenedioxy-methamphetamine (MDMA) in agonistic encounters between male mice.
    Progress in neuro-psychopharmacology & biological psychiatry, 1999, Volume: 23, Issue:2

    Topics: Aggression; Animals; Exploratory Behavior; Hallucinogens; Male; Mice; N-Methyl-3,4-methylenedioxyamp

1999
5-HT receptor knockout mice: pharmacological tools or models of psychiatric disorders.
    Annals of the New York Academy of Sciences, 1999, Apr-30, Volume: 868

    Topics: 3,4-Dihydroxyphenylacetic Acid; Aggression; Animals; Behavior, Animal; Cocaine; Disease Models, Anim

1999
Fact, fiction, and function: mythmaking and the social construction of ecstasy use.
    Substance use & misuse, 2001, Volume: 36, Issue:1-2

    Topics: Adolescent; Adult; Affect; Aggression; Culture; Female; Hallucinogens; Humans; Interpersonal Relatio

2001
Experimentally induced aggressive behavior in subjects with 3,4-methylenedioxy-methamphetamine ("Ecstasy") use history: psychobiological correlates.
    Journal of substance abuse, 2001, Volume: 13, Issue:4

    Topics: Adolescent; Adrenocorticotropic Hormone; Adult; Aggression; Analysis of Variance; Epinephrine; Hallu

2001
Sub-acute effects of MDMA (+/-3,4-methylenedioxymethamphetamine, "ecstasy") on mood: evidence of gender differences.
    Psychopharmacology, 2002, Volume: 161, Issue:1

    Topics: Adolescent; Adult; Affect; Aggression; Depression; Female; Humans; Male; N-Methyl-3,4-methylenedioxy

2002