n-hydroxy-n--aminoguanidine and Neoplasms

n-hydroxy-n--aminoguanidine has been researched along with Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for n-hydroxy-n--aminoguanidine and Neoplasms

Article	Year
N-hydroxy-N'-aminoguanidines as anti-cancer lead molecule: QSAR, synthesis and biological evaluation. Bioorganic & medicinal chemistry letters, 2011, Jun-01, Volume: 21, Issue:11 The intrinsic pharmacophore model (r(pred)(2) and r(m)(2) of 0.858 and 0.725) has been developed and used as a query to screen in-house built library based on N-hydroxy-N'-aminoguanidine (HAG) analogs. The pharmacophoric modeled based HITs were synthesized and evaluated for anticancer activity and cytotoxicity. One of the compounds (15) appeared as promising lead candidate with an IC(50) value of 11 μM yielded in HL-60 promyelocytic leukemia cells. Compound 15 reveals significantly lower cytotoxicity against HeLa and Vero cell with CC(50) values of more than 100 μM. Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Guanidines; HL-60 Cells; Humans; Inhibitory Concentration 50; Models, Biological; Molecular Structure; Neoplasms; Quantitative Structure-Activity Relationship; Small Molecule Libraries	2011

Article

Year

N-hydroxy-N'-aminoguanidines as anti-cancer lead molecule: QSAR, synthesis and biological evaluation.

Bioorganic & medicinal chemistry letters, 2011, Jun-01, Volume: 21, Issue:11

The intrinsic pharmacophore model (r(pred)(2) and r(m)(2) of 0.858 and 0.725) has been developed and used as a query to screen in-house built library based on N-hydroxy-N'-aminoguanidine (HAG) analogs. The pharmacophoric modeled based HITs were synthesized and evaluated for anticancer activity and cytotoxicity. One of the compounds (15) appeared as promising lead candidate with an IC(50) value of 11 μM yielded in HL-60 promyelocytic leukemia cells. Compound 15 reveals significantly lower cytotoxicity against HeLa and Vero cell with CC(50) values of more than 100 μM.

Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Guanidines; HL-60 Cells; Humans; Inhibitory Concentration 50; Models, Biological; Molecular Structure; Neoplasms; Quantitative Structure-Activity Relationship; Small Molecule Libraries

2011