n-glycylalanine has been researched along with Amyotrophic Lateral Sclerosis in 4 studies
*Amyotrophic Lateral Sclerosis: A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94) [MeSH]
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 2 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bai, L; Luo, B; Qi, S; Shen, C; Shu, X; Tu, WY; Wang, A; Wei, C; Xu, ZZ; Zhang, K; Zhang, SX; Zhong, K | 1 |
| Arzberger, T; Czuppa, M; Edbauer, D; Farny, D; Frottin, F; Hartl, FU; Hartmann, H; Hipp, MS; Khosravi, B; LaClair, KD; Mareljic, N; Michaelsen, M; Riemenschneider, H; Zhou, Q | 1 |
| Arzberger, T; Banzhaf-Strathmann, J; Edbauer, D; Grässer, FA; Hornburg, D; Kremmer, E; Mann, M; May, S; Meissner, F; Mori, K; Rentzsch, K; Schludi, MH; Schwenk, BM | 1 |
| Bauer, PO; Bieniek, KF; Boylan, KB; Castanedes-Casey, M; Chew, J; Daughrity, LM; Desaro, P; Dickson, DW; Edbauer, D; Fryer, JD; Gendron, TF; Jansen-West, K; Johnston, A; Kurti, A; Lee, CW; Murray, ME; Overstreet, K; Perkerson, EA; Petrucelli, L; Prudencio, M; Rademakers, R; Rousseau, L; Sasaguri, H; Stankowski, JN; Stetler, C; Whitelaw, EC; Zhang, YJ | 1 |
4 other study(ies) available for n-glycylalanine and Amyotrophic Lateral Sclerosis
| Article | Year |
|---|---|
Negative regulation of TREM2-mediated C9orf72 poly-GA clearance by the NLRP3 inflammasome.
Topics: Amyotrophic Lateral Sclerosis; Animals; C9orf72 Protein; Dipeptides; DNA Repeat Expansion; Frontotemporal Dementia; Inflammasomes; Mice; NLR Family, Pyrin Domain-Containing 3 Protein; Proteins | 2023 |
Cell-to-cell transmission of C9orf72 poly-(Gly-Ala) triggers key features of ALS/FTD.
Topics: Active Transport, Cell Nucleus; Amyotrophic Lateral Sclerosis; Animals; C9orf72 Protein; Cytoplasm; Dipeptides; DNA-Binding Proteins; Female; Frontotemporal Dementia; HeLa Cells; Humans; Male; Mice; Neurons; Nuclear Localization Signals; Proteasome Endopeptidase Complex; Protein Aggregation, Pathological; Ubiquitin | 2020 |
C9orf72 FTLD/ALS-associated Gly-Ala dipeptide repeat proteins cause neuronal toxicity and Unc119 sequestration.
Topics: Adaptor Proteins, Signal Transducing; Amyotrophic Lateral Sclerosis; Animals; Caspases; Cells, Cultured; Cerebral Cortex; Dipeptides; DNA Repeat Expansion; DNA-Binding Proteins; Frontotemporal Lobar Degeneration; Gene Expression Regulation; Green Fluorescent Proteins; HEK293 Cells; Humans; Microtubule-Associated Proteins; Rats; RNA-Binding Proteins; Transfection; Ubiquitin | 2014 |
Neurodegeneration. C9ORF72 repeat expansions in mice cause TDP-43 pathology, neuronal loss, and behavioral deficits.
Topics: Amyotrophic Lateral Sclerosis; Animals; Antisocial Personality Disorder; C9orf72 Protein; Cerebral Cortex; Dependovirus; Dipeptides; Disease Models, Animal; DNA-Binding Proteins; Frontotemporal Dementia; Gene Transfer Techniques; HEK293 Cells; Humans; Mice; Proteins; Purkinje Cells; RNA, Nuclear | 2015 |