n-desmethylclobazam has been researched along with Aura in 20 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (20.00) | 18.7374 |
| 1990's | 4 (20.00) | 18.2507 |
| 2000's | 4 (20.00) | 29.6817 |
| 2010's | 7 (35.00) | 24.3611 |
| 2020's | 1 (5.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bjørnvold, M; Burns, ML; Heger, K; Johannessen Landmark, C; Johannessen, SI; Lund, C; Sætre, E | 1 |
| James, A; Lake, C; Patsalos, PN; Ratnaraj, N; Sander, JW; Zugman, M | 1 |
| Bebin, EM; Cutter, GR; Gaston, TE; Liu, Y; Szaflarski, JP | 1 |
| Phelps, SJ; Russell, GR; Shelton, CM; Wheless, JW | 1 |
| Ikeda, H; Imai, K; Inoue, Y; Kagawa, Y; Kasai, R; Matsuda, K; Miyakawa, K; Mogami, Y; Nishimura, S; Takahashi, Y; Takayama, R; Terada, K; Yamaguchi, T; Yamamoto, Y | 1 |
| Ishitsu, T; Kaneko, S; Nagata, R; Nakagawa, K; Nakashima, H; Nishimura, M; Ogusu, N; Saruwatari, J; Seo, T; Shimomasuda, M; Tanikawa, K; Tsuda, Y; Yasui-Furukori, N | 1 |
| Bruno, PL; Geffrey, AL; Pollack, SF; Thiele, EA | 1 |
| Baftiu, A; Burns, ML; Johannessen, SI; Landmark, CJ; Opdal, MS | 1 |
| Giovanardi-Rossi, P; Parmeggiani, A; Posar, A; Sangiorgi, S | 1 |
| Kosaki, K; Samejima, H; Sato, R; Takahashi, T; Tamura, K; Tanigawara, Y | 1 |
| Aylett, SE; Berry, D; Cross, H | 1 |
| Begum, T; Ikeda, A; Kinoshita, M; Shibasaki, H; Terada, K | 1 |
| Jawad, S; Oxley, J; Richens, A | 1 |
| Nakamura, F; Nishimura, S; Seino, M; Suzuki, S; Yagi, K | 1 |
| Bardy, AH; Granström, ML; Salokorpi, T; Santavuori, P; Seppälä, T | 1 |
| Blaschuk, K; Couture, M; Guberman, A; Sherwin, A | 1 |
| Bun, H; Cano, JP; Durand, A; Monjanel-Mouterde, S; Noel, F | 1 |
| Feely, M; Garratt, JC; Gent, JP; Haigh, JR; Pullar, T | 1 |
| Feely, MP; Haigh, JR; Peaker, S; Pullar, T | 1 |
| Arranz Peña, MI; Sanenz Lope, E | 1 |
3 trial(s) available for n-desmethylclobazam and Aura
| Article | Year |
|---|---|
Efficacy of low-dose, add-on therapy of clobazam (CLB) is produced by its major metabolite, N-desmethyl-CLB.
Topics: Adult; Anticonvulsants; Benzodiazepines; Clobazam; Dose-Response Relationship, Drug; Epilepsy; Female; Humans; Male; Treatment Outcome | 2007 |
Add-on trial of clobazam in intractable adult epilepsy with plasma level correlations.
Topics: Adult; Aged; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Clobazam; Dose-Response Relationship, Drug; Epilepsy; Humans; Middle Aged; Seizures | 1990 |
Pharmacokinetics of N-desmethylclobazam in healthy volunteers and patients with epilepsy.
Topics: Adult; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Clobazam; Epilepsy; Female; Humans; Male | 1987 |
17 other study(ies) available for n-desmethylclobazam and Aura
| Article | Year |
|---|---|
Pharmacokinetic Variability During Long-Term Therapeutic Drug Monitoring of Valproate, Clobazam, and Levetiracetam in Patients With Dravet Syndrome.
Topics: Adolescent; Adult; Anticonvulsants; Benzodiazepines; Child; Child, Preschool; Clobazam; Dioxolanes; Drug Monitoring; Epilepsies, Myoclonic; Epilepsy; Female; Humans; Levetiracetam; Male; Middle Aged; Norway; Retrospective Studies; Valproic Acid; Young Adult | 2020 |
Serum protein binding of 25 antiepileptic drugs in a routine clinical setting: A comparison of free non-protein-bound concentrations.
Topics: Adult; Anticonvulsants; Benzodiazepines; Biological Availability; Blood-Brain Barrier; Carbamazepine; Epilepsy; Gas Chromatography-Mass Spectrometry; Humans; Protein Binding; Retrospective Studies | 2017 |
Interactions between cannabidiol and commonly used antiepileptic drugs.
Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Benzodiazepines; Cannabidiol; Child; Child, Preschool; Clobazam; Dose-Response Relationship, Drug; Drug Interactions; Epilepsy; Female; Fructose; Humans; Male; Middle Aged; Topiramate; Triazoles; Young Adult | 2017 |
Impact of Drug Interactions on Clobazam and N-Desmethylclobazam Concentrations in Pediatric Patients With Epilepsy.
Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Benzodiazepines; Child; Child, Preschool; Clobazam; Cytochrome P-450 CYP2C19 Inhibitors; Cytochrome P-450 CYP3A Inducers; Drug Interactions; Epilepsy; Female; Humans; Infant; Male; Retrospective Studies; Young Adult | 2018 |
Influence of CYP2C19 polymorphism and concomitant antiepileptic drugs on serum clobazam and N-desmethyl clobazam concentrations in patients with epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Asian People; Benzodiazepines; Clobazam; Cytochrome P-450 CYP2C19; Dose-Response Relationship, Drug; Drug Interactions; Epilepsy; Female; Humans; Japan; Male; Phenotype; Polymorphism, Genetic; Regression Analysis; Sensitivity and Specificity; Young Adult | 2013 |
Effects of CYP2C19 and P450 oxidoreductase polymorphisms on the population pharmacokinetics of clobazam and N-desmethylclobazam in japanese patients with epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Benzodiazepines; Body Weight; Child; Child, Preschool; Clobazam; Cytochrome P-450 CYP2C19; Drug Therapy, Combination; Epilepsy; Female; Gene Frequency; Humans; Infant; Japan; Male; Metabolic Clearance Rate; Middle Aged; NADPH-Ferrihemoprotein Reductase; Polymorphism, Genetic; Retrospective Studies; Sex Factors | 2014 |
Drug-drug interaction between clobazam and cannabidiol in children with refractory epilepsy.
Topics: Adolescent; Benzodiazepines; Cannabidiol; Child; Child, Preschool; Clobazam; Cytochrome P-450 Enzyme System; Drug Interactions; Epilepsy; Female; Humans; Male; Young Adult | 2015 |
Therapeutic Drug Monitoring of Clobazam and Its Metabolite-Impact of Age and Comedication on Pharmacokinetic Variability.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Anticonvulsants; Benzodiazepines; Child; Child, Preschool; Clobazam; Dose-Response Relationship, Drug; Drug Interactions; Drug Monitoring; Drug Therapy, Combination; Epilepsy; Female; Humans; Infant; Male; Middle Aged; Norway; Pharmacogenetics; Retrospective Studies; Young Adult | 2016 |
Unusual side-effects due to clobazam: a case report with genetic study of CYP2C19.
Topics: Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Benzodiazepines; Child; Clobazam; Cytochrome P-450 CYP2C19; Dyssomnias; Electroencephalography; Enuresis; Epilepsy; Female; Humans; Mixed Function Oxygenases; Mutation | 2004 |
A major influence of CYP2C19 genotype on the steady-state concentration of N-desmethylclobazam.
Topics: Adolescent; Adult; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Benzodiazepines; Child; Child, Preschool; Clobazam; Cytochrome P-450 CYP2C19; DNA Mutational Analysis; Dose-Response Relationship, Drug; Drug Resistance; Epilepsy; Female; Gene Frequency; Genetic Predisposition to Disease; Genetic Testing; Genotype; Humans; Infant; Japan; Male; Metabolic Clearance Rate; Mixed Function Oxygenases; Mutation; Phenotype; Polymorphism, Genetic | 2004 |
Eye rolling as a manifestation of clobazam toxicity in a child with epilepsy.
Topics: Anticonvulsants; Benzodiazepines; Child, Preschool; Clobazam; Dose-Response Relationship, Drug; Epilepsy; Humans; Lamotrigine; Male; Ocular Motility Disorders; Treatment Outcome; Triazines | 2006 |
Single dose pharmacokinetic study of clobazam in normal volunteers and epileptic patients.
Topics: Adolescent; Adult; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Carbamazepine; Clobazam; Enzyme Induction; Epilepsy; Female; Humans; Kinetics; Male; Phenytoin | 1984 |
Effects of clobazam and its active metabolite on GABA-activated currents in rat cerebral neurons in culture.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Cells, Cultured; Cerebral Cortex; Chloride Channels; Clobazam; Dose-Response Relationship, Drug; Epilepsy; Flumazenil; gamma-Aminobutyric Acid; Humans; Neurons; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, GABA; Synaptic Transmission | 1996 |
Monitoring of concentrations of clobazam and norclobazam in serum and saliva of children with epilepsy.
Topics: Adolescent; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Child; Child, Preschool; Chromatography, Gas; Clobazam; Drug Tolerance; Epilepsy; Female; Humans; Infant; Male; Saliva | 1991 |
Effects of age and antiepileptic drugs on plasma levels and kinetics of clobazam and N-desmethylclobazam.
Topics: Adolescent; Adult; Age Factors; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Carbamazepine; Child; Child, Preschool; Clobazam; Drug Therapy, Combination; Epilepsy; Humans; Infant; Phenobarbital; Phenytoin; Time Factors; Valproic Acid | 1990 |
Disappointing results of increasing benzodiazepine dose after the development of anticonvulsant tolerance.
Topics: Adult; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Clobazam; Dose-Response Relationship, Drug; Epilepsy; Female; Humans; Male; Middle Aged | 1988 |
Determination of clobazam and its N-demethyl metabolite in serum of epileptic patients.
Topics: Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Chromatography, Gas; Clobazam; Epilepsy; Humans | 1986 |