Compounds > n-cyano-n'-(1,1-dimethylpropyl)-n''-(3-pyridinyl)guanidine
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n-cyano-n'-(1,1-dimethylpropyl)-n''-(3-pyridinyl)guanidine and Muscle Contraction

n-cyano-n'-(1,1-dimethylpropyl)-n''-(3-pyridinyl)guanidine has been researched along with Muscle Contraction in 11 studies

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's8 (72.73)18.2507
2000's3 (27.27)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Manley, PW; Quast, U1
Altenbach, RJ; Bai, H; Brioni, JD; Brune, ME; Buckner, SA; Carroll, WA; Cassidy, C; Chen, Y; Coghlan, MJ; Daza, AV; Drizin, I; Fey, TA; Fitzgerald, M; Gopalakrishnan, M; Gregg, RJ; Henry, RF; Holladay, MW; King, LL; Kort, ME; Kym, PR; Milicic, I; Sullivan, JP; Tang, R; Turner, SC; Whiteaker, KL; Yi, L; Zhang, H1
Altenbach, RJ; Brune, ME; Buckner, SA; Carroll, WA; Coghlan, MJ; Daza, AV; Fabiyi, A; Gopalakrishnan, M; Henry, RF; Khilevich, A; Kort, ME; Milicic, I; Scott, VE; Smith, JC; Whiteaker, KL1
Brune, ME; Buckner, SA; Coghlan, M; Daza, A; Fey, TA; Gopalakrishnan, M; Milicic, I1
Linde, C; Quast, U1
Kau, ST; Li, JH; McConville, MW; Ohnmacht, CJ; Potter-Lee, L; Trainor, DA; Trivedi, S1
Sargent, C; Smith, MA; Weselcouch, EO; Wilde, MW1
Andres, H; Baumlin, Y; Bray, KM; Dosogne, J; Manley, PW; Quast, U1
Quast, U; Villhauer, EB1
Linde, C; Löffler, C; Quast, U1
Kessler, C; Linde, C; Löffler, C; Quast, U1

Other Studies

11 other study(ies) available for n-cyano-n'-(1,1-dimethylpropyl)-n''-(3-pyridinyl)guanidine and Muscle Contraction

ArticleYear
Structure-activity studies of potassium channel opening in pinacidil-type cyanoguanidines, nitroethenediamines, thioureas, and ureas.
    Journal of medicinal chemistry, 1992, Jun-12, Volume: 35, Issue:12

    Topics: Animals; Diamines; Guanidines; Ion Channel Gating; Male; Molecular Conformation; Molecular Structure; Muscle Contraction; Pinacidil; Portal Vein; Potassium Channels; Rats; Rats, Inbred Strains; Rubidium Radioisotopes; Structure-Activity Relationship; Thiourea; Urea; Vasodilator Agents

1992
Synthesis and structure-activity relationships of a novel series of 2,3,5,6,7,9-hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-dioxide K(ATP) channel openers: discovery of (-)-(9S)-9-(3-bromo-4-fluorophenyl)-2,3,5,6,7,9- hexahydrothieno[3,2-b]quinolin-8(4H)
    Journal of medicinal chemistry, 2004, Jun-03, Volume: 47, Issue:12

    Topics: Adenosine Triphosphate; Animals; Cyclic S-Oxides; Electric Stimulation; Guinea Pigs; Hemodynamics; In Vitro Techniques; Membrane Potentials; Muscle Contraction; Muscle, Smooth; Potassium Channels; Quinolones; Stereoisomerism; Structure-Activity Relationship; Swine; Urinary Bladder; Urodynamics

2004
Effects of substitution on 9-(3-bromo-4-fluorophenyl)-5,9-dihydro-3H,4H-2,6-dioxa-4- azacyclopenta[b]naphthalene-1,8-dione, a dihydropyridine ATP-sensitive potassium channel opener.
    Journal of medicinal chemistry, 2006, Nov-16, Volume: 49, Issue:23

    Topics: Adenosine Triphosphate; Animals; Aza Compounds; Cell Line; Crystallography, X-Ray; Dihydropyridines; Electric Stimulation; Heterocyclic Compounds, 3-Ring; In Vitro Techniques; Ion Channel Gating; Mice; Muscle Contraction; Muscle, Smooth; Naphthalenes; Potassium Channels, Inwardly Rectifying; Stereoisomerism; Structure-Activity Relationship; Swine; Urinary Bladder

2006
Pharmacological characterization of urinary bladder smooth muscle contractility following partial bladder outlet obstruction in pigs.
    European journal of pharmacology, 2006, Feb-17, Volume: 532, Issue:1-2

    Topics: Adenosine Triphosphate; Amides; Animals; Benzophenones; Carbachol; Cholinergic Agonists; Cromakalim; Cyclic S-Oxides; Diazoxide; Dose-Response Relationship, Drug; Electric Stimulation; Female; Guanidines; Histamine; Hypertrophy; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Potassium Channels; Potassium Chloride; Pyridines; Quinolones; Serotonin; Serotonin Agents; Swine; Urinary Bladder; Urinary Bladder Neck Obstruction; Vasodilator Agents

2006
Potentiation of P1075-induced K+ channel opening by stimulation of adenylate cyclase in rat isolated aorta.
    British journal of pharmacology, 1995, Volume: 115, Issue:3

    Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Aorta; Binding, Competitive; Bucladesine; Colforsin; Cyclic AMP-Dependent Protein Kinases; Drug Interactions; Enzyme Activation; Enzyme Inhibitors; Guanidines; In Vitro Techniques; Isoquinolines; Isotope Labeling; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Phosphodiesterase Inhibitors; Potassium Channels; Pyridines; Rats; Rats, Sprague-Dawley; Rubidium; Sulfonamides; Vasodilator Agents

1995
K-channel opening activity of dihydropyridine ZM244085: effect on 86Rb efflux and 3H-P1075 binding in urinary bladder smooth muscle.
    Research communications in molecular pathology and pharmacology, 1995, Volume: 88, Issue:2

    Topics: Acridines; Animals; Glyburide; Guanidines; Guinea Pigs; Humans; In Vitro Techniques; Isradipine; Muscle Contraction; Muscle, Smooth; Potassium Channels; Pyridines; Rubidium Radioisotopes; Urinary Bladder

1995
ATP-sensitive potassium channels and skeletal muscle function in vitro.
    The Journal of pharmacology and experimental therapeutics, 1993, Volume: 267, Issue:1

    Topics: Animals; Benzopyrans; Cromakalim; Electric Stimulation; Energy Metabolism; Gallamine Triethiodide; Glyburide; Guanidines; In Vitro Techniques; Ischemia; Male; Muscle Contraction; Muscles; Pinacidil; Potassium Channels; Pyridines; Pyrroles; Rats; Rats, Sprague-Dawley

1993
Binding of the K+ channel opener [3H]P1075 in rat isolated aorta: relationship to functional effects of openers and blockers.
    Molecular pharmacology, 1993, Volume: 43, Issue:3

    Topics: Adenosine Triphosphate; Animals; Aorta; Binding Sites; Cell Membrane; Guanidines; Hydrogen-Ion Concentration; In Vitro Techniques; Male; Membrane Potentials; Muscle Contraction; Muscle, Smooth, Vascular; Portal Vein; Potassium Channels; Pyridines; Rats; Rats, Sprague-Dawley; Temperature

1993
The individual enantiomers of cis-cromakalim possess K+ channel opening activity.
    European journal of pharmacology, 1993, Apr-15, Volume: 245, Issue:2

    Topics: Anesthesia; Animals; Aorta, Thoracic; Benzopyrans; Binding, Competitive; Blood Pressure; Cromakalim; Endothelium, Vascular; Guanidines; Heart Rate; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Portal Vein; Potassium Channels; Pyridines; Pyrroles; Rats; Rats, Wistar; Rubidium Radioisotopes; Stereoisomerism; Vasodilation; Vasodilator Agents

1993
Inhibition by protein kinase C of the 86Rb+ efflux and vasorelaxation induced by P1075, a K(ATP) channel opener, in rat isolated aorta.
    Naunyn-Schmiedeberg's archives of pharmacology, 1997, Volume: 356, Issue:3

    Topics: Adenosine Triphosphate; Animals; Aorta; Enzyme Activation; Enzyme Inhibitors; Guanidines; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Phorbol 12,13-Dibutyrate; Potassium Channels; Protein Binding; Protein Kinase C; Pyridines; Rats; Rats, Sprague-Dawley; Rubidium Radioisotopes; Tetradecanoylphorbol Acetate

1997
Interaction between thiol-modifying agents and P1075, a K(ATP) channel opener, in rat isolated aorta.
    Naunyn-Schmiedeberg's archives of pharmacology, 1997, Volume: 356, Issue:4

    Topics: Animals; Aorta; Dithiothreitol; Endothelium, Vascular; Guanidines; Hydroxymercuribenzoates; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Potassium Channels; Protein Binding; Pyridines; Radioactive Tracers; Rats; Rats, Sprague-Dawley; Rubidium; Sulfhydryl Reagents; Thimerosal; Vasodilator Agents

1997