n-caproylsphingosine and Cell-Transformation--Neoplastic

n-caproylsphingosine has been researched along with Cell-Transformation--Neoplastic* in 1 studies

Other Studies

1 other study(ies) available for n-caproylsphingosine and Cell-Transformation--Neoplastic

Article	Year
Differential roles of 2, 6, and 8 carbon ceramides on the modulation of gap junctional communication and apoptosis during carcinogenesis. Cancer letters, 2003, Feb-28, Volume: 191, Issue:1 The inhibition of apoptosis and gap junctional intercellular communication (GJIC) has been implicated in tumor promotion. Ionizing radiation and oxidative toxicants activate sphingomyelinases resulting in the release of ceramides that control cell proliferation and apoptosis. A rat liver epithelial cell line treated with ceramides containing a 6 (C6) or 8 (C8) carbon acyl-group were potent inhibitors of GJIC and apoptosis, whereas a C2-ceramide was only a weak inhibitor of GJIC and strong inducer of apoptosis. Apoptosis induced by either serum deprivation or C2-ceramide was inhibited by the GJIC inhibitory C8-ceramide. In conclusion, these results suggest that a chronic release of ceramides with acyl groups larger than C6 might act as tumor promoters. Topics: Animals; Apoptosis; Carcinogens; Cell Communication; Cell Line; Cell Transformation, Neoplastic; Ceramides; Dose-Response Relationship, Drug; Epithelial Cells; Gap Junctions; Liver; Molecular Structure; Rats; Rats, Inbred F344; Sphingosine; Structure-Activity Relationship	2003

Article

Year

Differential roles of 2, 6, and 8 carbon ceramides on the modulation of gap junctional communication and apoptosis during carcinogenesis.

Cancer letters, 2003, Feb-28, Volume: 191, Issue:1

The inhibition of apoptosis and gap junctional intercellular communication (GJIC) has been implicated in tumor promotion. Ionizing radiation and oxidative toxicants activate sphingomyelinases resulting in the release of ceramides that control cell proliferation and apoptosis. A rat liver epithelial cell line treated with ceramides containing a 6 (C6) or 8 (C8) carbon acyl-group were potent inhibitors of GJIC and apoptosis, whereas a C2-ceramide was only a weak inhibitor of GJIC and strong inducer of apoptosis. Apoptosis induced by either serum deprivation or C2-ceramide was inhibited by the GJIC inhibitory C8-ceramide. In conclusion, these results suggest that a chronic release of ceramides with acyl groups larger than C6 might act as tumor promoters.

Topics: Animals; Apoptosis; Carcinogens; Cell Communication; Cell Line; Cell Transformation, Neoplastic; Ceramides; Dose-Response Relationship, Drug; Epithelial Cells; Gap Junctions; Liver; Molecular Structure; Rats; Rats, Inbred F344; Sphingosine; Structure-Activity Relationship

2003