n-acetylserotonin has been researched along with Multiple Sclerosis in 3 studies
N-acetylserotonin : An N-acylserotonin resulting from the formal condensation of the primary amino group of serotonin with the carboxy group of acetic acid.
Multiple Sclerosis: An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (see MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur. (Adams et al., Principles of Neurology, 6th ed, p903)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Melatonin and N-acetylserotonin (NAS) are tryptophan metabolites that have potent anti-oxidant, anti-inflammatory and neuroprotective properties in several animal models of neurological injury and disease including multiple sclerosis (MS)." | 7.83 | Efficacy of N-Acetylserotonin and Melatonin in the EAE Model of Multiple Sclerosis. ( Ariyannur, PS; Kirmani, BF; Moffett, JR; Namboodiri, AM; Ribeiro, R; Tanaka, M; Wen, J; Zhang, Y, 2016) |
| "Melatonin and N-acetylserotonin (NAS) are tryptophan metabolites that have potent anti-oxidant, anti-inflammatory and neuroprotective properties in several animal models of neurological injury and disease including multiple sclerosis (MS)." | 3.83 | Efficacy of N-Acetylserotonin and Melatonin in the EAE Model of Multiple Sclerosis. ( Ariyannur, PS; Kirmani, BF; Moffett, JR; Namboodiri, AM; Ribeiro, R; Tanaka, M; Wen, J; Zhang, Y, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Mondanelli, G | 1 |
| Coletti, A | 1 |
| Greco, FA | 1 |
| Pallotta, MT | 1 |
| Orabona, C | 1 |
| Iacono, A | 1 |
| Belladonna, ML | 1 |
| Albini, E | 1 |
| Panfili, E | 1 |
| Fallarino, F | 1 |
| Gargaro, M | 1 |
| Manni, G | 1 |
| Matino, D | 1 |
| Carvalho, A | 1 |
| Cunha, C | 1 |
| Maciel, P | 1 |
| Di Filippo, M | 1 |
| Gaetani, L | 1 |
| Bianchi, R | 1 |
| Vacca, C | 1 |
| Iamandii, IM | 1 |
| Proietti, E | 1 |
| Boscia, F | 1 |
| Annunziato, L | 1 |
| Peppelenbosch, M | 1 |
| Puccetti, P | 1 |
| Calabresi, P | 1 |
| Macchiarulo, A | 1 |
| Santambrogio, L | 1 |
| Volpi, C | 1 |
| Grohmann, U | 1 |
| Anderson, G | 1 |
| Rodriguez, M | 1 |
| Wen, J | 1 |
| Ariyannur, PS | 1 |
| Ribeiro, R | 1 |
| Tanaka, M | 1 |
| Moffett, JR | 1 |
| Kirmani, BF | 1 |
| Namboodiri, AM | 1 |
| Zhang, Y | 1 |
1 review available for n-acetylserotonin and Multiple Sclerosis
| Article | Year |
|---|---|
Multiple sclerosis: the role of melatonin and N-acetylserotonin.
Topics: Fingolimod Hydrochloride; Glatiramer Acetate; Humans; Immunologic Factors; Immunosuppressive Agents; | 2015 |
2 other studies available for n-acetylserotonin and Multiple Sclerosis
| Article | Year |
|---|---|
Positive allosteric modulation of indoleamine 2,3-dioxygenase 1 restrains neuroinflammation.
Topics: Allosteric Regulation; Allosteric Site; Animals; Biocatalysis; Disease Models, Animal; Encephalomyel | 2020 |
Efficacy of N-Acetylserotonin and Melatonin in the EAE Model of Multiple Sclerosis.
Topics: Animals; Cells, Cultured; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Femal | 2016 |