n-acetylserotonin has been researched along with Melanoma in 4 studies
N-acetylserotonin : An N-acylserotonin resulting from the formal condensation of the primary amino group of serotonin with the carboxy group of acetic acid.
Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effects of melatonin, N-acetylserotonin and serotonin on the growth and tyrosinase activity of SK-Mel 23 and SK-Mel 28 human melanoma cell lines were investigated." | 7.72 | Melatonin biological activity and binding sites in human melanoma cells. ( Castrucci, AM; Souza, AV; Visconti, MA, 2003) |
| "Indolic and kynuric pathways of skin melatonin metabolism were monitored by liquid chromatography mass spectrometry in human keratinocytes, melanocytes, dermal fibroblasts, and melanoma cells." | 3.79 | Metabolism of melatonin and biological activity of intermediates of melatoninergic pathway in human skin cells. ( Fischer, TW; Janjetovic, Z; Kim, TK; Kleszczynski, K; Li, W; Lin, Z; Reiter, RJ; Slominski, AT; Sweatman, T, 2013) |
| "The effects of melatonin, N-acetylserotonin and serotonin on the growth and tyrosinase activity of SK-Mel 23 and SK-Mel 28 human melanoma cell lines were investigated." | 3.72 | Melatonin biological activity and binding sites in human melanoma cells. ( Castrucci, AM; Souza, AV; Visconti, MA, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (75.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yamazaki, Y | 1 |
| Kawano, Y | 1 |
| Yamanaka, A | 1 |
| Maruyama, S | 1 |
| Kim, TK | 1 |
| Kleszczynski, K | 1 |
| Janjetovic, Z | 1 |
| Sweatman, T | 2 |
| Lin, Z | 1 |
| Li, W | 1 |
| Reiter, RJ | 1 |
| Fischer, TW | 1 |
| Slominski, AT | 1 |
| Souza, AV | 1 |
| Visconti, MA | 1 |
| Castrucci, AM | 1 |
| Slominski, A | 1 |
| Pisarchik, A | 1 |
| Semak, I | 1 |
| Wortsman, J | 1 |
| Szczesniewski, A | 1 |
| Slugocki, G | 1 |
| McNulty, J | 1 |
| Kauser, S | 1 |
| Tobin, DJ | 1 |
| Jing, C | 1 |
| Johansson, O | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Role of Peripheral Serotonin in Oculocutaneous Albinism[NCT06138509] | 160 participants (Anticipated) | Observational | 2024-01-31 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 other studies available for n-acetylserotonin and Melanoma
| Article | Year |
|---|---|
N-[(Dihydroxyphenyl)acyl]serotonins as potent inhibitors of tyrosinase from mouse and human melanoma cells.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Drug Design; Drug Screening Assays, Antitumor; Enz | 2009 |
Metabolism of melatonin and biological activity of intermediates of melatoninergic pathway in human skin cells.
Topics: 5-Methoxytryptamine; Animals; Cell Differentiation; Cell Line; Cell Line, Tumor; Cells, Cultured; Ch | 2013 |
Melatonin biological activity and binding sites in human melanoma cells.
Topics: Binding Sites; Binding, Competitive; Cell Division; Humans; Iodine Radioisotopes; Melanoma; Melatoni | 2003 |
Serotoninergic and melatoninergic systems are fully expressed in human skin.
Topics: Acetylserotonin O-Methyltransferase; Arylamine N-Acetyltransferase; Cell Line; Gene Expression; Gene | 2002 |